Anthony H. Futerman
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Computer Science
Anthony H. Futerman's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Anthony H. Futerman's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The cell biology of lysosomal storage disorders (2004) (802)
- The complex life of simple sphingolipids (2004) (614)
- Mammalian ceramide synthases (2010) (480)
- When Do Lasses (Longevity Assurance Genes) Become CerS (Ceramide Synthases)? (2006) (417)
- Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. (2007) (378)
- CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. (2014) (333)
- Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. (1990) (327)
- A dynamic interface between vacuoles and mitochondria in yeast. (2014) (324)
- The metabolism and function of sphingolipids and glycosphingolipids (2007) (320)
- Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases* (2010) (318)
- The ins and outs of sphingolipid synthesis. (2005) (314)
- Characterization of Ceramide Synthase 2 (2008) (297)
- Gaucher disease: pathological mechanisms and modern management (2005) (284)
- Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors* (2003) (278)
- Upstream of Growth and Differentiation Factor 1 (uog1), a Mammalian Homolog of the Yeast Longevity Assurance Gene 1 (LAG1), RegulatesN-Stearoyl-sphinganine (C18-(Dihydro)ceramide) Synthesis in a Fumonisin B1-independent Manner in Mammalian Cells* (2002) (262)
- Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver. (1991) (254)
- X‐ray structure of human acid‐β‐glucosidase, the defective enzyme in Gaucher disease (2003) (249)
- Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins (1986) (224)
- A Critical Role for Ceramide Synthase 2 in Liver Homeostasis (2010) (215)
- The economics of neurite outgrowth — the addition of new membrane to growing axons (1996) (205)
- Ceramide Signaling Downstream of the p75 Neurotrophin Receptor Mediates the Effects of Nerve Growth Factor on Outgrowth of Cultured Hippocampal Neurons (1999) (189)
- Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. (1993) (182)
- Ceramide synthases as potential targets for therapeutic intervention in human diseases. (2014) (179)
- Elevation of Intracellular Glucosylceramide Levels Results in an Increase in Endoplasmic Reticulum Density and in Functional Calcium Stores in Cultured Neurons* (1999) (176)
- The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. (1993) (174)
- Sphingolipid Depletion Increases Formation of the Scrapie Prion Protein in Neuroblastoma Cells Infected with Prions* (1999) (171)
- Effect of ceramide structure on membrane biophysical properties: the role of acyl chain length and unsaturation. (2011) (167)
- Modes of attachment of acetylcholinesterase to the surface membrane. (1987) (163)
- A Critical Role for Ceramide Synthase 2 in Liver Homeostasis (2010) (159)
- A Regulatory Role for Sphingolipids in Neuronal Growth (1995) (159)
- Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain* (2013) (157)
- Ceramide as a second messenger: sticky solutions to sticky problems. (2000) (152)
- Cholera Toxin Is Found in Detergent-insoluble Rafts/Domains at the Cell Surface of Hippocampal Neurons but Is Internalized via a Raft-independent Mechanism* (2001) (151)
- Glucosylceramide and Glucosylsphingosine Modulate Calcium Mobilization from Brain Microsomes via Different Mechanisms* (2003) (151)
- Distinct Roles for Ceramide and Glucosylceramide at Different Stages of Neuronal Growth (1997) (149)
- Enhanced calcium release in the acute neuronopathic form of Gaucher disease (2005) (146)
- RIPK3 as a potential therapeutic target for Gaucher's disease (2014) (144)
- Death-associated Protein (DAP) Kinase Plays a Central Role in Ceramide-induced Apoptosis in Cultured Hippocampal Neurons* (2002) (142)
- Ceramide synthases: roles in cell physiology and signaling. (2010) (142)
- Inhibition of Calcium Uptake via the Sarco/Endoplasmic Reticulum Ca2+-ATPase in a Mouse Model of Sandhoff Disease and Prevention by Treatment with N-Butyldeoxynojirimycin* (2003) (139)
- Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond (2011) (139)
- Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent‐resistant membranes (2013) (136)
- The complexity of sphingolipid biosynthesis in the endoplasmic reticulum. (2013) (135)
- Nerve Growth Factor-induced p75-mediated Death of Cultured Hippocampal Neurons Is Age-dependent and Transduced through Ceramide Generated by Neutral Sphingomyelinase* (2002) (132)
- Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length. (2013) (129)
- Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease. (2012) (126)
- Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase. (1985) (123)
- Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration. (2014) (122)
- The Role of the Ceramide Acyl Chain Length in Neurodegeneration: Involvement of Ceramide Synthases (2010) (120)
- Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration. (1994) (120)
- Characterization of gene-activated human acid-β-glucosidase: Crystal structure, glycan composition, and internalization into macrophages (2009) (118)
- LASS5 Is a Bona Fide Dihydroceramide Synthase That Selectively Utilizes Palmitoyl-CoA as Acyl Donor* (2005) (117)
- (Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1 (2007) (115)
- Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner* (2009) (114)
- The roles of ceramide and complex sphingolipids in neuronal cell function. (2003) (113)
- Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C. (1985) (109)
- Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa (2014) (104)
- Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease. (2007) (104)
- Sphingolipids Are Required for the Stable Membrane Association of Glycosylphosphatidylinositol-anchored Proteins in Yeast* (2002) (103)
- New directions in the treatment of Gaucher disease. (2004) (102)
- Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. (1999) (99)
- Solubilization of Membrane‐Bound Acetyicholinesterase by a Phosphatidylinositol‐Specific Phospholipase C (1985) (98)
- The localization of gangliosides in neurons of the central nervous system: the use of anti-ganglioside antibodies. (1996) (96)
- Cationic Amphiphilic Drugs Inhibit the Internalization of Cholera Toxin to the Golgi Apparatus and the Subsequent Elevation of Cyclic AMP (*) (1995) (95)
- X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. (2005) (93)
- Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease. (2011) (92)
- Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C. (1988) (92)
- Modulation of Ceramide Synthase Activity via Dimerization* (2012) (90)
- A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C (1983) (90)
- Animal models for Gaucher disease research (2011) (85)
- Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations. (2009) (84)
- Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation (2018) (82)
- Kinetic characterization of mammalian ceramide synthases: Determination of K m values towards sphinganine (2007) (80)
- The pathogenesis of glycosphingolipid storage disorders. (2004) (80)
- Bcl2L13 is a ceramide synthase inhibitor in glioblastoma (2014) (76)
- Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses. (2010) (76)
- Intracellular trafficking of sphingolipids: relationship to biosynthesis. (2006) (75)
- Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide (2002) (75)
- Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane. (1993) (74)
- Ganglioside Synthesis during the Development of Neuronal Polarity (1996) (74)
- An appreciation of Dr Steven Pfeiffer, 1940–2007 (2007) (69)
- Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis? (2002) (68)
- Cholesterol depletion by methyl‐β‐cyclodextrin blocks cholera toxin transport from endosomes to the Golgi apparatus in hippocampal neurons (2001) (67)
- Encephalopathy Caused by Ablation of Very Long Acyl Chain Ceramide Synthesis May Be Largely Due to Reduced Galactosylceramide Levels* (2011) (66)
- Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes[S] (2012) (65)
- Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression. (2010) (62)
- Determination of the Localization of Gangliosides Using Anti-ganglioside Antibodies: Comparison of Fixation Methods (1997) (61)
- Defective calcium homeostasis in the cerebellum in a mouse model of Niemann–Pick A disease (2005) (61)
- Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models (2013) (61)
- A New Functional Motif in Hox Domain-containing Ceramide Synthases (2007) (60)
- Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans (2012) (59)
- The Yeast P5 Type ATPase, Spf1, Regulates Manganese Transport into the Endoplasmic Reticulum (2013) (58)
- Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases (2019) (58)
- CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance. (2014) (57)
- Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death (2017) (56)
- Analysis of glucocerebrosidase activity using N-(1-[14C]hexanoyl)-D-erythroglucosylsphingosine demonstrates a correlation between levels of residual enzyme activity and the type of Gaucher disease. (1994) (56)
- Myristate-derived d16:0 Sphingolipids Constitute a Cardiac Sphingolipid Pool with Distinct Synthetic Routes and Functional Properties* (2013) (56)
- Acyl Chain Specificity of Ceramide Synthases Is Determined within a Region of 150 Residues in the Tram-Lag-CLN8 (TLC) Domain* (2011) (54)
- SMPDL3b modulates insulin receptor signaling in diabetic kidney disease (2019) (53)
- Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity. (2015) (52)
- Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils (2015) (51)
- Glycosphingolipidoses: Beyond the enzymatic defect (2004) (50)
- A combined fluorescence spectroscopy, confocal and 2-photon microscopy approach to re-evaluate the properties of sphingolipid domains. (2013) (50)
- Induction of the type I interferon response in neurological forms of Gaucher disease (2016) (50)
- Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain (2014) (49)
- Inhibition of sphingolipid synthesis: effects on glycosphingolipid-GPI-anchored protein microdomains. (1995) (49)
- The increased sensitivity of neurons with elevated glucocerebroside to neurotoxic agents can be reversed by imiglucerase (2000) (49)
- The Role of Sphingolipids in the Maintenance of Fibroblast Morphology (1997) (49)
- No evidence for activation of the unfolded protein response in neuronopathic models of Gaucher disease. (2009) (49)
- Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy (2014) (48)
- Ceramide synthase 1 is regulated by proteasomal mediated turnover. (2009) (47)
- Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Evidence for a common membrane-anchoring structure. (1987) (47)
- Identification of Modifier Genes in a Mouse Model of Gaucher Disease. (2016) (46)
- Genetic diseases of sphingolipid metabolism: Pathological mechanisms and therapeutic options (2006) (46)
- Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure (2017) (46)
- Identification of a Biomarker in Cerebrospinal Fluid for Neuronopathic Forms of Gaucher Disease (2015) (45)
- Acid β-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy (2008) (45)
- Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length. (2014) (44)
- Delineating pathological pathways in a chemically induced mouse model of Gaucher disease (2016) (43)
- Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms. (2003) (42)
- Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins. (2013) (42)
- 6‐Amino‐6‐deoxy‐5,6‐di‐N‐(N′‐octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β‐Glucosidase (2009) (41)
- Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum* (2012) (41)
- Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. (2010) (41)
- Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease. (2006) (40)
- Up-regulation of Glucosylceramide Synthesis upon Stimulation of Axonal Growth by Basic Fibroblast Growth Factor (2000) (40)
- Reexamination of electrodiffusion time scales. (2009) (40)
- Neuronal forms of Gaucher disease. (2013) (39)
- Autoimmune Epilepsy: Some Epilepsy Patients Harbor Autoantibodies to Glutamate Receptors and dsDNA on both Sides of the Blood-brain Barrier, which may Kill Neurons and Decrease in Brain Fluids after Hemispherotomy (2004) (39)
- Ceramide synthases in biomedical research. (2016) (39)
- Self-segregation of myelin membrane lipids in model membranes. (2011) (39)
- Glucosylceramide Synthesis Is Required for Basic Fibroblast Growth Factor and Laminin to Stimulate Axonal Growth (1997) (38)
- Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization (2013) (38)
- Effect of glucosylceramide on the biophysical properties of fluid membranes. (2013) (37)
- Making Sense of the Yeast Sphingolipid Pathway. (2016) (37)
- Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease (2004) (37)
- Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions. (2001) (36)
- The internalization of a short acyl chain analogue of ganglioside GM1 in polarized neurons. (1996) (36)
- Molecular Basis of Reduced Glucosylceramidase Activity in the Most Common Gaucher Disease Mutant, N370S (2010) (35)
- Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension (2016) (34)
- Eleven residues determine the acyl chain specificity of ceramide synthases (2018) (32)
- Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues. (2011) (32)
- Protection of a Ceramide Synthase 2 Null Mouse from Drug-induced Liver Injury (2013) (32)
- Lipid diffusion in neurons (1993) (31)
- Inhibition of sphingolipid synthesis, but not degradation, alters the rate of dendrite growth in cultured hippocampal neurons. (1998) (31)
- 1-Methylthiodihydroceramide, a Novel Analog of Dihydroceramide, Stimulates Sphinganine Degradation Resulting in Decreased de Novo Sphingolipid Biosynthesis* (1998) (30)
- Up-regulation of Neutral Glycosphingolipid Synthesis upon Long Term Inhibition of Ceramide Synthesis by Fumonisin B1 * (1999) (30)
- Phosphatidylcholine metabolism is altered in a monocyte-derived macrophage model of Gaucher disease but not in lymphocytes. (2004) (30)
- Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein (2017) (30)
- Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases (2013) (30)
- In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling (2019) (29)
- Use of N-([1-14C]hexanoyl)-D-erythro-sphingolipids to assay sphingolipid metabolism. (1992) (28)
- Sphingolipids (2021) (27)
- Arrhenius plots of acetylcholinesterase activity in mammalian erythrocytes and in Torpedo electric organ. Effect of solubilization by proteinases and by a phosphatidylinositol-specific phospholipase C. (1985) (27)
- The Role of Sphingolipids in Neuronal Development: Lessons from Models of Sphingolipid Storage Diseases (2002) (26)
- A membrane-associated dimer of acetylcholinesterase from Xenopus skeletal muscle is solubilized by phosphatidylinositol-specific phospholipase C (1988) (26)
- The role of ceramide in regulating endoplasmic reticulum function. (2019) (25)
- An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+‐ATPase: relevance to gangliosidoses (2007) (25)
- Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons. (1999) (25)
- X-ray structure of human acid-beta-glucosidase covalently bound to conduritol B epoxide (2005) (25)
- LPS‐mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα‐converting enzyme (2015) (25)
- The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses (2014) (25)
- Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes. (2016) (24)
- Lysosomal storage disorders: old diseases, present and future challenges. (2013) (24)
- human acid-beta-glucosidase (2003) (24)
- Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety. (2000) (24)
- Innate immune responses in the brain of sphingolipid lysosomal storage diseases (2015) (23)
- Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease (2003) (23)
- Rate of Retrograde Transport of Cholera Toxin from the Plasma Membrane to the Golgi Apparatus and Endoplasmic Reticulum Decreases During Neuronal Development (1996) (22)
- Aminopropyl solid phase extraction and 2 D TLC of neutral glycosphingolipids and neutral lysoglycosphingolipids Published, JLR Papers in Press, October 1, 2002. DOI 10.1194/jlr.D200026-JLR200 (2003) (22)
- Elevation of lung surfactant phosphatidylcholine in mouse models of Sandhoff and of Niemann–Pick A disease (2004) (21)
- A lyso‐platelet activating factor phospholipase C, originally suggested to be a neutral‐sphingomyelinase, is located in the endoplasmic reticulum (2000) (21)
- From sheep to mice to cells: tools for the study of the sphingolipidoses. (2014) (21)
- Development of pheochromocytoma in ceramide synthase 2 null mice. (2015) (20)
- Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease (2017) (20)
- Intracellular localization of organized lipid domains of C16-ceramide/cholesterol. (2011) (20)
- De Novo Ceramide Synthesis Is Required for N-Linked Glycosylation in Plasma Cells1 (2009) (20)
- Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via KC a1.1 upregulation (2015) (19)
- A Stroll Down the CerS Lane. (2019) (19)
- Altered lysosome distribution is an early neuropathological event in neurological forms of Gaucher disease (2017) (19)
- A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction (2015) (19)
- The metabolism of glucocerebrosides - From 1965 to the present. (2017) (19)
- The brain lipidome in neurodegenerative lysosomal storage disorders. (2018) (19)
- Emerging therapeutic targets for Gaucher disease (2015) (19)
- Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity (2019) (18)
- The Exon 8-Containing Prosaposin Gene Splice Variant Is Dispensable for Mouse Development, Lysosomal Function, and Secretion (2005) (18)
- Fingolimod phosphate inhibits astrocyte inflammatory activity in mucolipidosis IV (2018) (18)
- Accumulation of ordered ceramide-cholesterol domains in farber disease fibroblasts. (2014) (16)
- Antibody Labeling of Cholesterol/Ceramide Ordered Domains in Cell Membranes (2007) (16)
- Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate‐induced colitis in mice due to increased intestinal permeability (2017) (16)
- Control of the rate of evaporation in protein crystallization by the ‘microbatch under oil’ method (2008) (16)
- Parallel increases in [α-125I]bungarotoxin binding and α7 nicotinic subunit immunoreactivity during the development of rat hippocampal neurons in culture (1997) (16)
- Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis (2017) (16)
- Isolation of gangliosides by cloud-point extraction with a nonionic detergent. (1997) (16)
- Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase[S] (2017) (16)
- Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson’s Disease (2020) (15)
- Glucosylceramide Reorganizes Cholesterol-Containing Domains in a Fluid Phospholipid Membrane. (2016) (15)
- Ceramide kinase-like (CERKL) interacts with neuronal calcium sensor proteins in the retina in a cation-dependent manner. (2012) (15)
- Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease (2019) (15)
- Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface (1987) (14)
- Absence of infiltrating peripheral myeloid cells in the brains of mouse models of lysosomal storage disorders (2018) (14)
- Regulatory Roles for Sphingolipids in the Growth of Polarized Neurons a (1998) (14)
- Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons. (2002) (14)
- A newly-synthesized GPI-anchored protein, TAG-1/axonin-1, is inserted into axonal membranes along the entire length of the axon and not exclusively at the growth cone (1996) (14)
- Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury. (2017) (14)
- Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection (2015) (14)
- Ceramide synthases: Reflections on the impact of Dr. Lina M. Obeid. (2021) (14)
- The diffusion of molecules in axonal plasma membranes: the sites of insertion of new membrane molecules and their distribution along the axon surface. (1998) (14)
- Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-beta-glucosidase mutant that causes Gaucher disease. (2011) (13)
- Differential susceptibility to phosphatidylinositol-specific phospholipase C of acetylcholinesterase in excitable tissues of embryonic and adult Torpedo ocellata. (1987) (13)
- Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride Published, JLR Papers in Press, May 1, 2003. DOI 10.1194/jlr.D300010-JLR200 (2003) (13)
- c-Abl activates RIPK3 signaling in Gaucher disease. (2021) (13)
- GBA mutations, glucosylceramide and Parkinson's disease (2021) (13)
- Influence of intracellular membrane pH on sphingolipid organization and membrane biophysical properties. (2014) (13)
- TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells (2019) (13)
- Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages. (2009) (12)
- An IgE‐dependent secretory response of mast cells can be induced by a glycosphingolipid‐specific monoclonal antibody (2000) (12)
- Perspective: Finding common ground (2016) (12)
- Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis (2017) (12)
- Chapter 4 – Ceramide Metabolism Compartmentalized in the Endoplasmic Reticulum and Golgi Apparatus (1994) (12)
- The fine‐tuning of cell membrane lipid bilayers accentuates their compositional complexity (2021) (12)
- Synthesis and biological evaluation of novel PDMP analogues. (2006) (12)
- KCa3.1 upregulation preserves endothelium‐dependent vasorelaxation during aging and oxidative stress (2016) (11)
- An Update on Sphingolipid Synthesis and Transport along the Secretory Pathway (1994) (11)
- Distinct roles for sphingolipids and glycosphingolipids at different stages of neuronal development. (1998) (11)
- Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis. (2017) (11)
- Substrate reduction therapy using Genz‐667161 reduces levels of pathogenic components in a mouse model of neuronopathic forms of Gaucher disease (2020) (11)
- The roles of ceramide in the regulation of neuronal growth and development. (1998) (10)
- Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha. (2007) (10)
- Regulation of sphingolipid and glycosphingolipid metabolism during neuronal growth and development. (1999) (10)
- Cellular Pathology in Gaucher Disease (2006) (10)
- Immunolocalization of gangliosides by light microscopy using anti-ganglioside antibodies. (2000) (9)
- X-ray Structure of Human Acid-β-Glucosidase Covalently Bound to Conduritol-B-Epoxide (2005) (8)
- A kibbutz full of lipidsLipids: Regulatory Functions in Membrane Traffic and Cell Development Kfar Blum Kibbutz Guest House, Galilee, Israel, May 10–15, 1998 (1998) (8)
- Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease (2020) (7)
- Sphingomyelin synthesis in endosomal compartments? (1995) (7)
- Lipid domain formation and membrane shaping by C24-ceramide. (2020) (7)
- The role of the 'sphingoid motif' in shaping the molecular interactions of sphingolipids in biomembranes. (2021) (7)
- Reversion of the biochemical defects in murine embryonic Sandhoff neurons using a bicistronic lentiviral vector encoding hexosaminidase α and β (2006) (7)
- Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans (2017) (6)
- Early perceptual loss in depression (2007) (6)
- Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways (2021) (6)
- Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons (1999) (6)
- Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis (2020) (6)
- Ceramide synthase 2 deletion decreases the infectivity of HIV-1 (2021) (5)
- Reversion of the biochemical defects in murine embryonic Sandhoff neurons using a bicistronic lentiviral vector encoding hexosaminidase alpha and beta. (2006) (5)
- SOLUBILIZATION OF MEMBRANE-BOUND ACETYLCHOLINESTERASE BY A PHOSiHATIDYLINOSITOL-SPEEIFIC PHOSEHOLI PÄSE C: ENZYMATIC AND PHYSICOCHIMICAL STUDIES (1984) (5)
- A novel C-terminal DxRSDxE motif in ceramide synthases involved in dimer formation (2021) (5)
- 16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis (2021) (5)
- Chapter 10 – Sphingolipids (2016) (5)
- Cell biology: Taxi service for lipids (2007) (5)
- Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death (2021) (4)
- Calcium homeostasis in lysosomal storage diseases (2009) (4)
- Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids (2020) (4)
- The Complex Tail of Circulating Sphingolipids in Atherosclerosis and Cardiovascular Disease (2021) (4)
- NPC1 silent variant induces skipping of exon 11 (p.V562V) and unfolded protein response was found in a specific Niemann‐Pick type C patient (2020) (4)
- Lipids: The plasma membrane code. (2010) (4)
- Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer (2021) (4)
- Lipid Analysis: A Practical Approach edited by R. J. Hamilton and S. Hamilton. Oxford University Press, New York, 1994, cloth ISBN 0199630984, $60.00; paperback ISBN 0199630992, $42.00 (2002) (4)
- Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis (2022) (4)
- Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid β-Glucosidase (2007) (4)
- The Cell Biology of SARS-CoV-2 (2020) (4)
- Cellular pathogenesis in sphingolipid storage disorders: the quest for new therapeutic approaches (2010) (3)
- Parallel increases in [alpha-125I]bungarotoxin binding and alpha 7 nicotinic subunit immunoreactivity during the development of rat hippocampal neurons in culture. (1997) (3)
- Nerve cell death induced by Ca2+ ionophores in dissociated hippocampal cultures. Protective action of the NMDA antagonist MK-801. (1997) (3)
- Elevation of gangliosides in four brain regions from Parkinson’s disease patients with a GBA mutation (2022) (3)
- Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells (2021) (3)
- Brain pathology and cerebellar purkinje cell loss in a mouse model of chronic neuronopathic Gaucher disease (2020) (3)
- Ceramide turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (3)
- Vesicle transport during cell growth and in the maintenance of cell polarity. (1995) (3)
- Lysosomal Disorders of the Brain Edited by Frances Platt and Steven Walkley (2004) (2)
- Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages (2021) (2)
- Cloud-point extraction of gangliosides using nonionic detergent C14EO6. (2000) (2)
- Inhibition by anti-(nicotinic acetylcholine receptor) antibodies of acetylcholine-induced dopamine release from striatal nerve terminals (1981) (2)
- The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway (2022) (2)
- FAM57B is a modulator of ceramide synthesis that regulates sphingolipid homeostasis and synaptic composition in the developing brain (2021) (1)
- Ceramide in the Regulation of Neuronal Development: Two Faces of a Lipid (2013) (1)
- Biophysical impact of sphingosine and other abnormal lipid accumulation in Niemann-Pick disease type C cell models. (2021) (1)
- Preface to the Special Issue on brain lipids. (2015) (1)
- Crystal structure of the enzyme acid β-glucosidase (2013) (1)
- The Lysosome and Nonmotor Symptoms: Linking Parkinson's Disease and Lysosomal Storage Disorders (2020) (1)
- Regulation of (di‐hydro) ceramide synthase 1 (2008) (1)
- A kibbutz full of lipids. Lipids: regulatory functions in membrane traffic and cell development; 1998 May 10-15; Israel (1998) (1)
- Laurdan in live cell imaging: Effect of acquisition settings, cell culture conditions and data analysis on generalized polarization measurements. (2022) (1)
- The X-ray structure of human acid-beta-glucosidase : Implications for second-generation enzyme replacement therapy (2006) (1)
- Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells (2021) (1)
- Sphingolipid and Glycolipid Biology (2006) (0)
- X-RAY STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH 5N,6S-(N'-(N-OCTYL)IMINO)-6-THIONOJIRIMYCIN IN THE ACTIVE SITE (2011) (0)
- Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases (2023) (0)
- Ceramide turnover in GtoPdb v.2021.3 (2021) (0)
- Finding common ground PERSPECTIVE Finding common ground (2016) (0)
- 38 Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa (2015) (0)
- Corrigendum to “Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length” [Mol. Cell Biol. Lipids 1841(12) (2014) 1754–1766] (2015) (0)
- Induction of the type I interferon response in neurological forms of Gaucher disease (2016) (0)
- Myristate‐derived d16:0‐sphingolipids constitute an abundant cardiac sphingolipid pool with distinct synthetic routes and functional properties (2013) (0)
- X-ray structure of acid-beta-glucosidase with N-octyl(cyclic guanidine)-nojirimycin in the active site (2009) (0)
- Gaucher Associations Around the World (2006) (0)
- 1 Defective neuronal function in LSDs (2007) (0)
- acid-beta-glucosidase produced in carrot (2008) (0)
- Partially deglycosylated glucoceramidase (2006) (0)
- BioCosmos: New Perspectives on the Origin and Evolution of Life (2021) (0)
- Heat Inactivation of Gamma-Glutamyltransferase in Homogenates of Human Kidney (1982) (0)
- Preface (2007) (0)
- In Memoriam: Dan Tawfik (2021) (0)
- Molecular determinants of a lipid droplet subpopulation at the contact site between the nucleus and vacuole (2017) (0)
- Assessing Niemann-Pick Type C (NP-C) through a multi-omics approach genomic and transcriptomic profile of challenging cases (2019) (0)
- Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience Eilat, Israel, November 25–27, 2007 (2008) (0)
- Ceramide turnover (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database (2020) (0)
- De fi ciency Reduces Ductular Reaction , Hepatocyte Apoptosis , and Liver Fibrosis in (2016) (0)
- X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells (2008) (0)
- NPC1 silent variant affecting splicing (p.Val562Val) and unfold protein response in an NPC patient (2020) (0)
- A Storm in a Primordial Teacup (2022) (0)
- Elevation of gangliosides in four brain regions from Parkinson’s disease patients with a GBA mutation (2022) (0)
- Brain spingolipids in hyperglycemia (2015) (0)
- The roles of sphingolipids in regulating neuronal growth and development (1999) (0)
- Neuronal Cell Death in Glycosphingolipidoses (2006) (0)
- SMPDL3b modulates insulin receptor signaling in diabetic kidney disease (2019) (0)
- Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif (2022) (0)
- When cells stash their trash (2004) (0)
- Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis (2020) (0)
- The complexities of sphingolipid synthesis (2009) (0)
- Membranes for membranes' sake Biomembranes — General principles (vol. 1) (1996) (0)
- The 16p11.2-Linked Gene, FAM57B Encodes a Modulator of Ceramide Synthesis that Regulates Lipid Levels and Synaptic Composition in the Developing Brain (2021) (0)
- Lack of CerS2 Suppresses the Development of Experimental Autoimmune Encephalomyelitis by Impairing the Migratory Potential of Neutrophils (P5.343) (2016) (0)
- Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification. (2023) (0)
- 233. Towards Reversing Sandhoff Pathology by Lentiviral-Mediated Gene Therapy (2005) (0)
- Excototoxic autoimmunity to the glutamate receptor (1998) (0)
- Activation of Ceramide Synthases in RAW 264.7 Macrophages by Oxidized Phospholipids (2012) (0)
- Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease (2020) (0)
- acid-beta-glucosidase with N-butyl-deoxynojirimycin (2007) (0)
- THE INVOLVEMENT OF PHOSPHATIDYLINOSITOL IN THE ANCHORING OF HYDROPHOBIC FORMS OF ACETYLCHOLINESTERASE TO THE PLASMA MEMBRANE (1985) (0)
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