Anthony P. Bretscher
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British biologist
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Anthony P. Bretscherbiology Degrees
Biology
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#5163
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Molecular Biology
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Genetics
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Biology
Anthony P. Bretscher's Degrees
- Masters Genetics University of Oxford
- PhD Molecular Biology Imperial College London
Why Is Anthony P. Bretscher Influential?
(Suggest an Edit or Addition)According to Wikipedia, Anthony P. Bretscher is a professor of cell biology at Cornell University in the Department of Molecular Biology & Genetics in the College of Arts and Sciences. After training as a physicist at the University of Cambridge, Dr. Bretscher earned his Ph.D. in genetics with Simon Baumberg at the University of Leeds. From there, he was a European Molecular Biology Organization Fellow in the Department of Biochemistry at Stanford University with Dale Kaiser. He then went as a Max Planck Society Fellow to the Department of Biochemistry in the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany to work with Klaus Weber. In 1980, he was appointed to the faculty in the Cell Biology Department at the University of Texas Southwestern Medical School. He relocated to Cornell in 1981.
Anthony P. Bretscher's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Global Mapping of the Yeast Genetic Interaction Network (2004) (2113)
- ERM proteins and merlin: integrators at the cell cortex (2002) (1380)
- Organizing the cell cortex: the role of ERM proteins (2010) (808)
- Role of Formins in Actin Assembly: Nucleation and Barbed-End Association (2002) (773)
- A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor (1999) (662)
- Polarization of cell growth in yeast. (2000) (650)
- Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain (2000) (596)
- Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family (1997) (590)
- The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. (1998) (542)
- An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton* (1998) (501)
- Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast (2002) (490)
- Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. (2000) (459)
- Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. (1995) (442)
- Synergism between morphogenetic mutants of Myxococcus xanthus. (1978) (420)
- Villin is a major protein of the microvillus cystoskeleton which binds both G and F actin in a calcium-dependent manner (1980) (419)
- Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. (1993) (418)
- Mechanisms of polarized growth and organelle segregation in yeast. (2004) (417)
- Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor (1989) (386)
- ERM-Merlin and EBP50 protein families in plasma membrane organization and function. (2000) (380)
- Regulation of cortical structure by the ezrin-radixin-moesin protein family. (1999) (376)
- Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast. (1998) (353)
- Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. (1997) (352)
- Myosin V orientates the mitotic spindle in yeast (2000) (327)
- Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells (1983) (285)
- Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures (1980) (283)
- Microfilament structure and function in the cortical cytoskeleton. (1991) (282)
- Construction of a GAL1-regulated yeast cDNA expression library and its application to the identification of genes whose overexpression causes lethality in yeast. (1992) (273)
- Parallel secretory pathways to the cell surface in yeast (1995) (272)
- The Cooh-Terminal Domain of Myo2p, a Yeast Myosin V, Has a Direct Role in Secretory Vesicle Targeting (1999) (265)
- Villin: the major microfilament-associated protein of the intestinal microvillus. (1979) (252)
- Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton (1989) (249)
- cDNA cloning and sequencing of the protein‐tyrosine kinase substrate, ezrin, reveals homology to band 4.1. (1989) (238)
- Smooth muscle caldesmon. Rapid purification and F-actin cross-linking properties. (1984) (233)
- Localization of actin and microfilament-associated proteins in the microvilli and terminal web of the intestinal brush border by immunofluorescence microscopy (1978) (230)
- T cell antigen receptor signaling and immunological synapse stability require myosin IIA (2009) (226)
- Nutrition of Myxococcus xanthus, a fruiting myxobacterium (1978) (224)
- Secretory vesicle transport velocity in living cells depends on the myosin-V lever arm length (2002) (214)
- Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis (1995) (213)
- The Carboxyl-terminal Region of EBP50 Binds to a Site in the Amino-terminal Domain of Ezrin That Is Masked in the Dormant Molecule* (1998) (208)
- Fimbrin is a cytoskeletal protein that crosslinks F-actin in vitro. (1981) (183)
- Immunohistochemical localization of several cytoskeletal proteins in inner ear sensory and supporting cells (1982) (181)
- The secretion‐stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli. (1991) (179)
- Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast (2003) (169)
- Stable and dynamic axes of polarity use distinct formin isoforms in budding yeast. (2004) (168)
- Organizing the cell cortex: the role of ERM proteins (2010) (162)
- The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein (1986) (159)
- C-terminal threonine phosphorylation activates ERM proteins to link the cell's cortical lipid bilayer to the cytoskeleton. (1998) (156)
- Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions (1995) (150)
- Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. (2000) (147)
- Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable. (1993) (140)
- Identification and localization of immunoreactive forms of caldesmon in smooth and nonmuscle cells: a comparison with the distributions of tropomyosin and alpha-actinin (1985) (139)
- Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes. (2001) (127)
- Expression of the cytoskeleton linker protein ezrin in human cancers (2007) (125)
- Structure, regulation, and functional diversity of microvilli on the apical domain of epithelial cells. (2015) (124)
- Polarization of cell growth in yeast II . The role of the cortical actin cytoskeleton (2000) (120)
- Calcium control of the intestinal microvillus cytoskeleton: its implications for the regulation of microfilament organizations. (1980) (119)
- Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain (1999) (118)
- Purification of microvilli and an analysis of the protein components of the microfilament core bundle. (1978) (116)
- Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins. (1993) (113)
- Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central α-Helical Domain (2007) (109)
- Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network. (2011) (107)
- Structure of the Active N-terminal Domain of Ezrin (2003) (104)
- Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin (2007) (102)
- Preliminary biochemical characterization of the stereocilia and cuticular plate of hair cells of the chick cochlea (1989) (102)
- PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast. (2011) (102)
- Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport. (1992) (97)
- Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport (1992) (95)
- Insight into the molecular basis of pathogen abundance: Group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells (2002) (90)
- Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains. (1995) (89)
- Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells (2012) (88)
- EPI64 regulates microvillar subdomains and structure (2006) (80)
- Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway. (2001) (79)
- Identification of Epi64, a Tbc/Rabgap Domain–Containing Microvillar Protein That Binds to the First PDZ Domain of Ebp50 and E3karp (2001) (78)
- Reassociation of microvillar core proteins: making a microvillar core in vitro (1989) (78)
- Distinct cell type-specific expression of scaffolding proteins EBP50 and E3KARP: EBP50 is generally expressed with ezrin in specific epithelia, whereas E3KARP is not. (2002) (76)
- Smooth muscle caldesmon is an extended flexible monomeric protein in solution that can readily undergo reversible intra- and intermolecular sulfhydryl cross-linking. A mechanism for caldesmon's F-actin bundling activity. (1987) (74)
- Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells. (1992) (71)
- The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain (2004) (70)
- Calcium-regulated cooperative binding of the microvillar 110K- calmodulin complex to F-actin: formation of decorated filaments (1987) (69)
- Villin associates with specific microfilamentous structures as seen by immunofluorescence microscopy on tissue sections and cells microinjected with villin. (1981) (69)
- Inhibition and Redistribution of NHE3, the Apical Na+/H+ Exchanger, by Clostridium difficile Toxin B (2004) (69)
- Cellular retinaldehyde-binding protein interacts with ERM-binding phosphoprotein 50 in retinal pigment epithelium. (2004) (69)
- The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner (2010) (69)
- The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast. (1995) (68)
- Regulation of actin-based apical structures on epithelial cells (2018) (67)
- Microinjection of villin into cultured cells induces rapid and long- lasting changes in cell morphology but does not inhibit cytokinesis, cell motility, or membrane ruffling (1990) (66)
- A Regulated Complex of the Scaffolding Proteins PDZK1 and EBP50 with Ezrin Contribute to Microvillar Organization (2010) (66)
- What are the basic functions of microfilaments? Insights from studies in budding yeast (1994) (65)
- Microfilaments and microtubules: the news from yeast. (2002) (62)
- Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function. (2012) (62)
- The tumor suppressor merlin controls growth in its open state, and phosphorylation converts it to a less-active more-closed state. (2012) (60)
- Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans (2012) (60)
- Microfilaments and membranes. (1993) (57)
- Polarized growth and organelle segregation in yeast (2003) (56)
- The surprising dynamics of scaffolding proteins (2014) (56)
- Ezrin mutants affecting dimerization and activation. (2005) (55)
- Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. (2007) (55)
- Purification of tropomyosin from Saccharomyces cerevisiae and identification of related proteins in Schizosaccharomyces and Physarum. (1989) (54)
- Tracking individual secretory vesicles during exocytosis reveals an ordered and regulated process (2015) (54)
- Caldesmon: Thin filament regulatory proteins of smooth- and non-muscle cells (1986) (52)
- Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells. (2014) (49)
- Active Segregation of Yeast Mitochondria by Myo2 Is Essential and Mediated by Mmr1 and Ypt11 (2013) (47)
- PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli (2012) (47)
- Interactome Analysis Reveals Ezrin Can Adopt Multiple Conformational States* (2013) (45)
- The calmodulin and F-actin binding sites of smooth muscle caldesmon lie in the carboxyl-terminal domain whereas the molecular weight heterogeneity lies in the middle of the molecule. (1989) (43)
- Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism (2017) (43)
- The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50. (2009) (43)
- Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat LH receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway. (2001) (42)
- Tropomyosin from bovine brain contains two polypeptide chains of slightly different molecular weights (1978) (40)
- Mapping of the microvillar 110K-calmodulin complex: calmodulin- associated or -free fragments of the 110-kD polypeptide bind F-actin and retain ATPase activity (1988) (40)
- Purification of the intestinal microvillus cytoskeletal proteins villin, fimbrin, and ezrin. (1986) (39)
- The UBX Protein SAKS1 Negatively Regulates Endoplasmic Reticulum-associated Degradation and p97-dependent Degradation* (2010) (37)
- alpha-Actinins from chicken skeletal muscle and smooth muscle show considerable chemical and immunological differences. (1979) (36)
- Microtubule Asymmetry (2003) (33)
- The Yeast Formin Bnr1p Has Two Localization Regions That Show Spatially and Temporally Distinct Association with Septin Structures (2010) (33)
- A Zn-finger/FH2-domain containing protein, FOZI-1, acts redundantly with CeMyoD to specify striated body wall muscle fates in the Caenorhabditis elegans postembryonic mesoderm (2007) (33)
- Analysis of unregulated formin activity reveals how yeast can balance F-actin assembly between different microfilament-based organizations. (2008) (32)
- Plasma membranes from intestinal microvilli and erythrocytes contain cytochromes b5 and P-420. (1980) (32)
- Polarized growth in budding yeast in the absence of a localized formin. (2009) (31)
- Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains (2014) (30)
- Head-to-tail regulation is critical for the in vivo function of myosin V (2015) (30)
- Microvillus 110K-calmodulin: effects of nucleotides on isolated cytoskeletons and the interaction of the purified complex with F-actin (1985) (28)
- Yeast actin is relatively well behaved. (1992) (28)
- Identification and molecular characterization of the calmodulin‐binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae (1992) (27)
- Erratum: Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast (2002) (26)
- EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking (2012) (26)
- ATPase activity of the microvillar 110 kDa polypeptide‐calmodulin complex is activated in Mg2+ and inhibited in K+‐EDTA by F‐actin (1987) (26)
- F-actin aggregates in transformed cells contain alpha-actinin and fimbrin but apparently lack tropomyosin. (1986) (25)
- Microfilament organization in the cytoskeleton of the intestinal brush border. (1983) (23)
- Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation (2012) (22)
- Hibernation induces expression of moesin in intestinal epithelial cells. (1998) (22)
- Divergent transcription of the argECBH cluster of escherichia coli k12. Mutations which alter the control of enzyme synthesis. (1976) (21)
- Characterization and ultrastructural role of the major components of the intestinal microvillus cytoskeleton. (1982) (20)
- Rapid Glucose Depletion Immobilizes Active Myosin V on Stabilized Actin Cables (2014) (20)
- Dynamic association of moesin with the membrane skeleton of thrombin- activated platelets. (1999) (18)
- The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics (2013) (18)
- Molecular architecture of the microvillus cytoskeleton. (1983) (18)
- Purification of caldesmon. (1986) (17)
- Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo (2016) (16)
- Mutations synthetically lethal with tpm1delta lie in genes involved in morphogenesis. (1997) (15)
- Effector-mediated ERM activation locally inhibits RhoA activity to shape the apical cell domain (2021) (15)
- Regulated phosphorylation of budding yeast's essential myosin V heavy chain, Myo2p. (2006) (15)
- Induced morphological changes in isolated microvilli: regulation of membrane topology in vitro by submembranous microfilaments. (1983) (14)
- Identification of EPI 64 , a TBC / rabGAP Domain – containing Microvillar Protein That Binds to the First PDZ Domain of EBP 50 and E 3 KARP (2001) (13)
- Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables (2018) (12)
- Mapping of the microvillar 110K-calmodulin complex (brush border myosin I). Identification of fragments containing the catalytic and F-actin-binding sites and demonstration of a calcium ion dependent conformational change. (1990) (12)
- Brush border myosin-I microinjected into cultured cells is targeted to actin-containing surface structures. (1994) (11)
- Identification and molecular characterization of the calmodulin-binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae. An alpha-factor inducible gene. (1992) (10)
- The cytoskeletal linker protein moesin: decreased levels in Wiskott‐Aldrich syndrome platelets and identification of a cleavage pathway in normal platelets (1999) (10)
- Landmark mapping: a general method for localizing cysteine residues within a protein. (1989) (10)
- Molecular aspects of microfilament structure and assembly (1991) (6)
- Structure of the active FERM domain of Ezrin (2003) (6)
- The cytoskeleton: from regulation to function (2000) (5)
- The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation (2015) (5)
- Fodrin is part of a filamentous cortical sheath of the detergent resistant cytoskeleton of cultured cells before and after cytochalasin treatment. (1986) (4)
- The UBX Protein SAKS 1 Negatively Regulates Endoplasmic Reticulum-associated Degradation and p 97-dependent Degradation * (2011) (4)
- Epithelial polarity: dual Lkb1 pathways regulate apical microvilli. (2009) (3)
- Yeast Rgd3 is a phospho-regulated F-BAR-containing RhoGAP involved in the regulation of Rho3 distribution and cell morphology (2020) (3)
- Preparation of immobilized monomeric actin and its use in the isolation of protease-free and ribonuclease-free pancreatic deoxyribonuclease I. (1989) (3)
- Immunoblot detection of antigens in immunoprecipitates. (2001) (3)
- Microtubule tips redirect actin assembly. (2005) (3)
- Deconstructing formin-dependent actin cable assembly (2013) (2)
- Magazine or journal—what is the difference? The role of the monitoring editor (2013) (2)
- High-resolution secretory timeline from vesicle formation at the Golgi to fusion at the plasma membrane in S. cerevisiae (2022) (2)
- Cell and muscle motility. Volume 6 Edited by J. W. Shay. New York: Plenum Press. (1985). 377 pp. $49.50 (1985) (1)
- PKA type II mediates NHE3 inhibition by change of the pHi dependency: The role of E3KARP and NHERF (1998) (1)
- Yeast Rgd3 is a phospho-regulated F-BAR–containing RhoGAP involved in the regulation of Rho3 distribution and cell morphology (2020) (1)
- ARHGAP18-Ezrin functions as a RhoA autoregulatory module in the organization of apical microvilli (2022) (1)
- The tumor suppressor merlin controls growth in its open state and is converted by phosphorylation to a less-active more- closed state (2013) (1)
- Cloning and analyzing genes encoding cytoskeletal proteins in yeast Saccharomyces cerevisiae. (1991) (1)
- Erm-M Erlin and Ebp50 P Rotein F Amilies in P Lasma M Embrane O Rganization and F Unction (2000) (0)
- Microvilli, myosin contractility and apical actin organization are regulated locally though ezrin bound gaps (2022) (0)
- Two Cultures and the Revolution in Biotechnology (2004) (0)
- CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX (2000) (0)
- The Essence of Cell Polarity: Insights from Budding Yeast (2009) (0)
- The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells † (2021) (0)
- Moesin FERM domain bound to EBP50 C-terminal peptide (2004) (0)
- [Analysis of substances inhibiting regeneration by statistical methods]. (1952) (0)
- JCB_201411010 1..7 (2015) (0)
- RhoA effectors LOK/SLK activate ERM proteins to locally inhibit RhoA and define apical morphology (2020) (0)
- Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1 (2022) (0)
- Fimbrm is a cytoskeletal protein that crosslinks F-actin in vitro ( microfilaments / brush border / microvilli / membrane ruffles (0)
- Merlin-ezrin interactions in the metastatic outcome of osteosarcoma (2006) (0)
- Mutations Synthetically Lethal Wxth @ nlA Lie in Genes Involved in Morphogenesis (2002) (0)
- LOK/SLK kinases and ERM proteins function together to regulate apical morphology and inhibit RhoA signaling (2020) (0)
- Table of Contents (1991) (0)
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