Tony Pawson

Q: What Schools Are Affiliated With Tony Pawson

Tony Pawson is affiliated with the following schools: Nara Institute of Science and Technology, Yale University, University of Ottawa, Charles University, University of British Columbia, National Autonomous University of Mexico, Queen's University at Kingston, Stanford University, University of Toronto, King's College London, Harvard University

Tony Pawson 's AcademicInfluence.com Rankings

Tony Pawson

Biology

#2618

World Rank

#4128

Historical Rank

Cell Biology

#52

World Rank

#56

Historical Rank

Neuroscience

#241

World Rank

#255

Historical Rank

Biochemistry

#225

World Rank

#283

Historical Rank

biology Degrees

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Biology

Why Is Tony Pawson Influential?

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According to Wikipedia, Anthony James Pawson was a British-born Canadian scientist. Biography Born in Maidstone, England, the son of the sportsman and writer Tony Pawson, and botanist and high-school teacher Hilarie, he was the eldest of three children. He was educated at Winchester College and Clare College, Cambridge, where he received an MA in biochemistry followed by a PhD from King's College London in 1976. From 1976 to 1980 he pursued postdoctoral work at the University of California, Berkeley. From 1981 to 1985, he was Assistant Professor in microbiology at the University of British Columbia.

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Tony Pawson 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry (2002) (3689)
SH2 domains recognize specific phosphopeptide sequences (1993) (2618)
Protein modules and signalling networks (1995) (2401)
Signaling through scaffold, anchoring, and adaptor proteins. (1997) (2247)
Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. (1994) (1996)
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. (1991) (1664)
Assembly of Cell Regulatory Systems Through Protein Interaction Domains (2003) (1403)
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction (1992) (1312)
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family (2012) (1287)
The CRAPome: a Contaminant Repository for Affinity Purification Mass Spectrometry Data (2013) (1234)
Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles (2015) (1135)
β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB (2002) (1107)
BIND: the Biomolecular Interaction Network Database (2001) (1024)
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases (1992) (934)
The discoidin domain receptor tyrosine kinases are activated by collagen. (1997) (934)
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav (1994) (926)
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 (1993) (915)
SH2 and SH3 domains: From structure to function (1992) (886)
Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis (1996) (883)
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. (2006) (852)
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication (2001) (812)
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity (2000) (794)
Specificity in Signal Transduction From Phosphotyrosine-SH2 Domain Interactions to Complex Cellular Systems (2004) (783)
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. (1994) (763)
ICOS is essential for effective T-helper-cell responses (2001) (750)
Systematic Discovery of In Vivo Phosphorylation Networks (2007) (747)
Dynamic modularity in protein interaction networks predicts breast cancer outcome (2009) (727)
Protein-protein interactions define specificity in signal transduction. (2000) (714)
A Global Protein Kinase and Phosphatase Interaction Network in Yeast (2010) (682)
Reading protein modifications with interaction domains (2006) (666)
Syk tyrosine kinase required for mouse viability and B-cell development (1995) (664)
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases (1990) (642)
The Biomolecular Interaction Network Database and related tools 2005 update (2004) (637)
Post-translational modifications in signal integration (2010) (627)
Dissecting virulence: systematic and functional analyses of a pathogenicity island. (2004) (619)
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. (1993) (605)
Protein phosphorylation in signaling--50 years and counting. (2005) (588)
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. (1996) (581)
Cell Signaling in Space and Time: Where Proteins Come Together and When They’re Apart (2009) (573)
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses (1994) (569)
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands (1996) (540)
Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System (1996) (538)
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos (1993) (526)
The Hippo pathway regulates Wnt/beta-catenin signaling. (2010) (525)
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. (1990) (516)
A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps (1986) (509)
Bcr‐Abl oncoproteins bind directly to activators of the Ras signalling pathway. (1994) (494)
Proteomic, Functional, and Domain-Based Analysis of In Vivo 14-3-3 Binding Proteins Involved in Cytoskeletal Regulation and Cellular Organization (2004) (476)
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture (2004) (475)
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp‐2 (1997) (474)
SH2 and SH3 domains (1993) (455)
Repulsive Axon Guidance Abelson and Enabled Play Opposing Roles Downstream of the Roundabout Receptor (2000) (443)
Linear Motif Atlas for Phosphorylation-Dependent Signaling (2008) (442)
EphB receptor activity suppresses colorectal cancer progression (2005) (423)
Src homology region 2 domains direct protein-protein interactions in signal transduction. (1990) (416)
An experimentally derived confidence score for binary protein-protein interactions (2008) (415)
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene (1989) (412)
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor–MAP kinase–fos signalling pathway (1997) (410)
Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation (1998) (398)
SH2 domains, interaction modules and cellular wiring. (2001) (395)
The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils (1998) (392)
Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions (2013) (391)
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl (2003) (381)
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells (2001) (375)
A Rich1/Amot Complex Regulates the Cdc42 GTPase and Apical-Polarity Proteins in Epithelial Cells (2006) (373)
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes (2006) (373)
PreBIND and Textomy – mining the biomedical literature for protein-protein interactions using a support vector machine (2003) (365)
Structural Basis for Autoinhibition of the EphB2 Receptor Tyrosine Kinase by the Unphosphorylated Juxtamembrane Region (2001) (365)
Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein (1995) (364)
Unified Nomenclature for Eph Family Receptors and Their Ligands, the Ephrins (1997) (343)
UNC-73 Activates the Rac GTPase and Is Required for Cell and Growth Cone Migrations in C. elegans (1998) (338)
The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. (1993) (337)
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. (1996) (334)
The Receptor Tyrosine Kinase EphB2 Regulates NMDA-Dependent Synaptic Function (2001) (318)
Phosphotyrosine Signaling: Evolving a New Cellular Communication System (2010) (317)
NetworKIN: a resource for exploring cellular phosphorylation networks (2007) (315)
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product (2001) (293)
Binding of GAP to activated PDGF receptors. (1990) (292)
The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. (2006) (291)
Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype (2003) (291)
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells (1997) (285)
Discoidin Domain Receptor 1 Tyrosine Kinase Has an Essential Role in Mammary Gland Development (2001) (283)
Selective methyl group protonation of perdeuterated proteins. (1996) (273)
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins. (1993) (271)
Positional cloning of heart and soul reveals multiple roles for PKCλ in zebrafish organogenesis (2001) (265)
The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif* (1999) (263)
Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control (2006) (263)
Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein (1996) (263)
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein (1991) (262)
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization (1999) (261)
The PTB domain: a new protein module implicated in signal transduction. (1995) (261)
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice (1993) (257)
Mapping differential interactomes by affinity purification coupled with data independent mass spectrometry acquisition (2013) (257)
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. (1991) (257)
The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor (1991) (256)
Regulation and targets of receptor tyrosine kinases. (2002) (256)
Temporal regulation of EGF signaling networks by the scaffold protein Shc1 (2013) (253)
Deciphering arginine methylation: Tudor tells the tale (2011) (250)
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. (2013) (250)
Mutational activation of c-raf-1 and definition of the minimal transforming sequence (1990) (247)
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC‐gamma. (1990) (246)
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. (1992) (244)
Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development (2013) (243)
Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2 (1999) (241)
The Protein Kinase Clk/Sty Directly Modulates SR Protein Activity: Both Hyper- and Hypophosphorylation Inhibit Splicing (1999) (237)
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. (1996) (236)
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein–protein interactions (1996) (234)
Protein Modules and Signaling Networks (2000) (234)
Identification and characterization of NleA, a non‐LEE‐encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7 (2004) (232)
WW Domains Provide a Platform for the Assembly of Multiprotein Networks (2005) (229)
Defining the Specificity Space of the Human Src Homology 2 Domain*S (2008) (228)
Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice (2002) (227)
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin–Expressing Cells (2009) (225)
Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction. (1988) (221)
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses (2003) (221)
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring (2019) (220)
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. (1994) (217)
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-γ1 complexed with a high affinity binding peptide (1994) (217)
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity (2007) (215)
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint (2010) (215)
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor (2011) (212)
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling (2002) (211)
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. (1993) (210)
PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. (1998) (210)
Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors (2000) (205)
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. (2000) (203)
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer (2004) (201)
The N‐terminal region of GAP regulates cytoskeletal structure and cell adhesion. (1993) (200)
Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation (2008) (199)
Downregulation of the Ras–Mitogen-Activated Protein Kinase Pathway by the EphB2 Receptor Tyrosine Kinase Is Required for Ephrin-Induced Neurite Retraction (2001) (199)
Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases (2009) (197)
Tyr721 regulates specific binding of the CSF‐1 receptor kinase insert to PI 3′‐kinase SH2 domains: a model for SH2‐mediated receptor‐target interactions. (1992) (196)
SH2 and SH3 domains (1992) (193)
SH2 domain specificity and activity modified by a single residue (1994) (190)
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. (1993) (190)
Dynamic control of signaling by modular adaptor proteins. (2007) (188)
The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network (2003) (187)
Disruption of T cell signaling networks and development by Grb2 haploid insufficiency (2001) (186)
Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. (1994) (183)
Par3 and Dynein Associate to Regulate Local Microtubule Dynamics and Centrosome Orientation during Migration (2009) (182)
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi (2009) (180)
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination (2015) (178)
Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. (1994) (178)
Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases (2000) (176)
The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. (1997) (176)
Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease (2011) (174)
The v-Src SH3 domain binds phosphatidylinositol 3'-kinase (1993) (173)
Network medicine (2008) (172)
Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. (2001) (172)
High-throughput phosphotyrosine profiling using SH2 domains. (2007) (171)
A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides (1995) (170)
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. (1996) (169)
Construction of human activity-based phosphorylation networks (2013) (166)
A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. (1992) (164)
The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics* (2008) (161)
A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. (1991) (160)
Direct interaction between Shc and the platelet-derived growth factor beta-receptor. (1994) (157)
Interaction domains: from simple binding events to complex cellular behavior (2002) (156)
Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach (1993) (156)
Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. (2005) (153)
ShcA signalling is essential for tumour progression in mouse models of human breast cancer (2008) (153)
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. (1994) (152)
SH2 and SH3 domains in signal transduction. (1994) (152)
Signaling Networks—Do All Roads Lead to the Same Genes? (1999) (151)
Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation (2000) (148)
Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development. (1990) (148)
Role of P120 Ras-Gap in Directed Cell Movement (2000) (147)
Mammalian SH2-Containing Protein Tyrosine Phosphatases (1996) (146)
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor (1990) (146)
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins (2015) (143)
Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. (1988) (141)
The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1 (1998) (141)
Soluble FLT1 Binds Lipid Microdomains in Podocytes to Control Cell Morphology and Glomerular Barrier Function (2012) (140)
Diversity in protein recognition by PTB domains. (1999) (138)
Direct demonstration of an intramolecular SH2—phosphotyrosine interaction in the Crk protein (1995) (138)
Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition. (2003) (137)
The Tyrosine Phosphatase PTP1C Associates with Vav, Grb2, and mSos1 in Hematopoietic Cells (*) (1996) (137)
Modular evolution of phosphorylation-based signalling systems (2012) (137)
ProHits: an integrated software platform for mass spectrometry-based interaction proteomics (2010) (137)
Structure and mutagenesis of the Dbl homology domain (1998) (137)
RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2 (1997) (136)
Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF‐induced DNA synthesis: evidence for the existence of Ras‐dependent and Ras‐independent pathways. (1996) (135)
A High-Affinity Arg-X-X-Lys SH3 Binding Motif Confers Specificity for the Interaction between Gads and SLP-76 in T Cell Signaling (2002) (135)
Phosphorylation Networks Regulating JNK Activity in Diverse Genetic Backgrounds (2008) (132)
Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain (2010) (132)
Polarity proteins in axon specification and synaptogenesis. (2005) (132)
Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β (1998) (130)
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells (2014) (130)
Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor. (1993) (128)
Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer (2008) (128)
A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation (1980) (128)
Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly (2004) (128)
Oncogenic re-wiring of cellular signaling pathways (2007) (127)
Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis (2011) (125)
Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor. (1999) (124)
Discoidin Domain Receptor 1 Is Activated Independently of β1 Integrin* (2000) (123)
Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein (1985) (123)
Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling. (2013) (123)
The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development (2000) (122)
Eukaryotic Protein Domains as Functional Units of Cellular Evolution (2009) (122)
The Mammalian ShcB and ShcC Phosphotyrosine Docking Proteins Function in the Maturation of Sensory and Sympathetic Neurons (2000) (121)
Role of Syk in B-cell development and antigen-receptor signaling. (2000) (121)
Structure of a Numb PTB domain–peptide complex suggests a basis for diverse binding specificity (1998) (117)
Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A (1999) (116)
Podocyte-specific loss of Cdc42 leads to congenital nephropathy. (2012) (116)
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function. (2007) (114)
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes (2014) (113)
SH3 binding domains in the dopamine D4 receptor. (1998) (113)
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade (2010) (113)
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit. (1995) (112)
Mutagenesis of Fujinami Sarcoma Virus: Evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity (1984) (112)
Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor (1992) (112)
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions (2020) (110)
raf family serine/threonine protein kinases in mitogen signal transduction. (1988) (108)
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. (1996) (107)
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. (1996) (107)
Phosphorylated YDXV Motifs and Nck SH2/SH3 Adaptors Act Cooperatively To Induce Actin Reorganization (2008) (107)
Shc products are substrates of erbB-2 kinase. (1993) (105)
Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis (1984) (103)
The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice (1994) (103)
Nck adaptor proteins control the organization of neuronal circuits important for walking (2007) (102)
Nck proteins maintain the adult glomerular filtration barrier. (2009) (102)
Non-canonical Interaction of Phosphoinositides with Pleckstrin Homology Domains of Tiam1 and ArhGAP9* (2007) (101)
Positive Selection of Tyrosine Loss in Metazoan Evolution (2009) (101)
Functional Interaction between c-Src and Its Mitotic Target, Sam 68 (*) (1995) (100)
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases (2006) (100)
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins (2003) (99)
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors (1993) (98)
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes (2008) (97)
Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2–SOS and CrkII–C3G complexes (1998) (96)
Mathematical Modeling Suggests Cooperative Interactions between a Disordered Polyvalent Ligand and a Single Receptor Site (2003) (95)
Kinome signaling through regulated protein-protein interactions in normal and cancer cells. (2009) (95)
A ‘three‐pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome (2002) (94)
Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors (2011) (94)
Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck (1992) (94)
Cell communication: the inside story. (2000) (93)
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2. (1999) (93)
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb (2000) (92)
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. (1993) (91)
Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase. (1994) (90)
Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses (2006) (89)
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function (1989) (88)
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase. (1994) (88)
Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse. (1993) (87)
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading (2004) (86)
Getting down to specifics (1995) (85)
Identification of a Novel Inhibitory Actin-capping Protein Binding Motif in CD2-associated Protein* (2006) (84)
Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3 (2008) (84)
The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains. (1992) (84)
A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains (*) (1995) (84)
MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes. (1995) (82)
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. (2004) (82)
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap (1997) (80)
Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains. (1992) (80)
Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. (2006) (79)
Manipulation of EphB2 Regulatory Motifs and SH2 Binding Sites Switches MAPK Signaling and Biological Activity* (2003) (79)
Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2 (1991) (78)
Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice (1990) (76)
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide (2002) (76)
A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell. (1987) (76)
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. (1994) (76)
A quantitative liposome microarray to systematically characterize protein-lipid interactions (2013) (75)
Screening for PTB Domain Binding Partners and LigandSpecificity Using Proteome-Derived NPXY Peptide Arrays (2006) (75)
FF Domains of CA150 Bind Transcription and Splicing Factors through Multiple Weak Interactions (2004) (74)
SH2/SH3 Adaptor Proteins Can Link Tyrosine Kinases to a Ste20-related Protein Kinase, HPK1* (1997) (74)
Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation (1995) (74)
Characterization of elk, a brain-specific receptor tyrosine kinase (1991) (72)
A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction (1992) (72)
Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. (1995) (72)
The size of Rous sarcoma virus mRNAs active in cell-free translation (1977) (72)
UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. (2002) (71)
NOS1AP Associates with Scribble and Regulates Dendritic Spine Development (2010) (71)
Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase. (1996) (70)
Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62. (1992) (69)
Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. (1995) (69)
The Grb2-mSos1 Complex Binds Phosphopeptides with Higher Affinity than Grb2* (1996) (68)
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. (1997) (66)
Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1 (2002) (66)
The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans. (2005) (66)
High Affinity Binding of the Pleckstrin Homology Domain of mSos1 to Phosphatidylinositol (4,5)-Bisphosphate* (1997) (66)
Combinatorial ShcA Docking Interactions Support Diversity in Tissue Morphogenesis (2007) (65)
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways (2009) (64)
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. (2004) (63)
Analysis of a Shc Family Adaptor Protein, ShcD/Shc4, That Associates with Muscle-Specific Kinase (2007) (63)
New impressions of Src and Hck (1997) (62)
A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase (1995) (62)
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain (2007) (62)
Netrin Stimulates Tyrosine Phosphorylation of the UNC-5 Family of Netrin Receptors and Induces Shp2 Binding to the RCM Cytodomain* (2001) (62)
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5. (1993) (62)
Signalling change: signal transduction through the decades (2013) (60)
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis (2015) (60)
Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis (2001) (60)
A lysine in the ATP‐binding site of P130gag‐fps is essential for protein‐tyrosine kinase activity. (1986) (60)
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase (2012) (60)
Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate (2013) (58)
Screening for PTB Domain Binding Partners and Ligand Specificity Using Proteome-Derived NPXY Peptide Arrays (2007) (58)
The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family (1989) (57)
Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display (2010) (57)
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms (1992) (57)
Structure and function of SH2 domains (1994) (57)
Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor (2015) (57)
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells (2013) (55)
Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways. (1993) (54)
Modification of the Creator recombination system for proteomics applications – improved expression by addition of splice sites (2006) (54)
ShcA and Grb2 mediate polyoma middle T antigen‐induced endothelial transformation and Gab1 tyrosine phosphorylation (2001) (52)
TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3 (2004) (52)
Phospholipase C isozymes: structural and functional similarities. (1990) (50)
The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains (1991) (49)
A Potential SH3 Domain-binding Site in the Crk SH2 Domain* (1996) (49)
Efficient T‐cell receptor signaling requires a high‐affinity interaction between the Gads C‐SH3 domain and the SLP‐76 RxxK motif (2007) (49)
The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression (2017) (49)
Ectopic EphA4 receptor induces posterior protrusions via FGF signaling in Xenopus embryos. (2004) (49)
Multiple SH2-mediated interactions in v-src-transformed cells (1992) (49)
Salmonella exploits Arl8B‐directed kinesin activity to promote endosome tubulation and cell‐to‐cell transfer (2011) (48)
Myelin-associated glycoprotein, a cell adhesion molecule of oligodendrocytes, is phosphorylated in brain (1988) (48)
Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase (1993) (48)
Structural basis for specificity switching of the Src SH2 domain. (2000) (48)
Editorial overview: Signal transduction and growth control in normal and cancer cells (1994) (48)
Cell-free translation of virion RNA from nondefective and transformation-defective Rous sarcoma viruses (1976) (48)
Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease (2012) (47)
The unique insert of cellular and viral fms protein tyrosine kinase domains is dispensable for enzymatic and transforming activities. (1989) (47)
Hippocampal Synaptic Modulation by the Phosphotyrosine Adapter Protein ShcC/N-Shc via Interaction with the NMDA Receptor (2005) (47)
Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock (2012) (47)
Cell signaling : principles and mechanisms (2015) (46)
Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C. (1990) (46)
Functional Analysis of the Caenorhabditis elegans UNC-73B PH Domain Demonstrates a Role in Activation of the Rac GTPase In Vitro and Axon Guidance In Vivo (2003) (46)
Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. (1993) (46)
Signal transduction--a conserved pathway from the membrane to the nucleus. (1993) (45)
A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts (2012) (44)
Signal transduction: Mad about SMADs (1997) (44)
Tyrosine kinases and their interactions with signalling proteins. (1992) (44)
Accelerated Mammary Tumor Development in Mutant Polyomavirus Middle T Transgenic Mice Expressing Elevated Levels of Either the Shc or Grb2 Adapter Protein (1999) (43)
Mapping of multiple phosphorylation sites within the structural and catalytic domains of the Fujinami avian sarcoma virus transforming protein (1983) (42)
The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia. (2004) (42)
Synthetic modular systems – reverse engineering of signal transduction (2005) (41)
Cell-free translation of avian erythroblastosis virus RNA (1980) (41)
Regulation of a ras-related protein during development of Dictyostelium discoideum (1985) (40)
RS cyclophilins: identification of an NK-TR1-related cyclophilin. (1996) (40)
Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition (2017) (40)
Regulation of Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase (Btk) through a Novel SH3-Dependent Interaction with Ankyrin Repeat Domain 54 (ANKRD54) (2012) (39)
BIND: THE BIOMOLECULAR INTERACTION DATABASE (2001) (38)
Biochemistry of the Src protein-tyrosine kinase: regulation by SH2 and SH3 domains. (1994) (38)
Nck Adapters Are Involved in the Formation of Dorsal Ruffles, Cell Migration, and Rho Signaling Downstream of the Platelet-derived Growth Factor β Receptor* (2008) (38)
Novel NEDD1 phosphorylation sites regulate &ggr;-tubulin binding and mitotic spindle assembly (2012) (37)
C-Terminal Domain of the Epstein-Barr Virus LMP2A Membrane Protein Contains a Clustering Signal (2001) (37)
Role of raf oncogenes in lung carcinogenesis (1988) (35)
The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism (2014) (35)
Tyrosine kinase signalling pathways. (1994) (35)
Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation. (2014) (34)
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy (2015) (33)
Cooperative transforming activities of ras, myc, and src viral oncogenes in nonestablished rat adrenocortical cells (1988) (33)
MAPK Signaling: Sho Business (2004) (33)
Distribution and patterns of staining of Neu oncogene product in benign and malignant breast diseases. (1990) (32)
The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction. (2007) (32)
T Cell Activation-Induced CrkII Binding to the Zap70 Protein Tyrosine Kinase Is Mediated by Lck-Dependent Phosphorylation of Zap70 Tyrosine 3151 (2005) (32)
Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity. (1988) (32)
Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction. (2006) (32)
Gravin is a transitory effector of polo-like kinase 1 during cell division. (2012) (32)
Profiling the kinome: current capabilities and future challenges. (2013) (32)
Leukocyte‐specific protein 1 links TNF receptor‐associated factor 1 to survival signaling downstream of 4‐1BB in T cells (2013) (32)
Introduction: Protein Kinases (1994) (31)
The Epstein-Barr Virus Protein, Latent Membrane Protein 2A, Co-opts Tyrosine Kinases Used by the T Cell Receptor* (2005) (31)
Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners. (2014) (31)
Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase (1989) (31)
MERTK Interactions with SH2-Domain Proteins in the Retinal Pigment Epithelium (2013) (31)
The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity (1988) (30)
Cell-Free Translation of Virion RNA from Nondefective and Transformation-Defective Rous Sarcoma Viruses (1977) (30)
Low-Molecular-Weight Protein Tyrosine Phosphatase Is a Positive Component of the Fibroblast Growth Factor Receptor Signaling Pathway (2002) (30)
Viral transformation of chick myogenic cells. The relationship between differentiation and the expression of the SRC gene. (1979) (29)
The Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid-Imidazolide Alters Transforming Growth Factor β-dependent Signaling and Cell Migration by Affecting the Cytoskeleton and the Polarity Complex* (2008) (29)
Cardiac and neurological abnormalities in v-fps transgenic mice. (1989) (29)
Catalytic and non-catalytic domains of the Fujinami sarcoma virus P130gag-fps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli. (1987) (28)
Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation (2014) (28)
env Gene of Rous sarcoma virus: identification of the gene product by cell-free translation (1980) (28)
p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2. (1990) (28)
Tyrosine phosphorylation of GAP and GAP-associated proteins in lymphoid and fibroblast cells expressing lck. (1991) (27)
The ShcA Phosphotyrosine Docking Protein Uses Distinct Mechanisms to Regulate Myocyte and Global Heart Function (2011) (27)
The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50. (2004) (27)
Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase. (1994) (27)
Structural basis for the interaction between the cell polarity proteins Par3 and Par6 (2018) (27)
Signal transduction in the control of cell growth and development. (1991) (26)
Organization of cell–regulatory systems through modular–protein–interaction domains (2003) (26)
OpenFreezer: a reagent information management software system (2011) (26)
Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response. (2010) (26)
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1 (2010) (25)
Protein kinase activity of FSV (Fujinami sarcoma virus) P130gag-fps shows a strict specificity for tyrosine residues. (1986) (25)
Mapping protein interactions by combining antibody affinity maturation and mass spectrometry (2011) (25)
Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire (2010) (25)
UNC-73/Trio RhoGEF-2 Activity Modulates Caenorhabditis elegans Motility Through Changes in Neurotransmitter Signaling Upstream of the GSA-1/Gαs Pathway (2011) (25)
Activated Src tyrosine kinase phosphorylates Tyr-457 of bovine GTPase-activating protein (GAP) in vitro and the corresponding residue of rat GAP in vivo. (1992) (25)
EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain (2009) (25)
Enzymatic activation of Fujinami sarcoma virus gag‐fps transforming proteins by autophosphorylation at tyrosine. (1987) (25)
The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3. (2000) (24)
The ShcA SH2 domain engages a 14-3-3/PI3′K signaling complex and promotes breast cancer cell survival (2012) (24)
Vagaries of Vav (1992) (23)
Immature T-cell clustering and efficient differentiation require the polarity protein Scribble (2010) (23)
Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide‐based arrays (2008) (23)
Protein-tyrosine kinases. Getting down to specifics. (1995) (23)
A retrovirus encoding the v-fps protein-tyrosine kinase induces factor-independent growth and tumorigenicity in FDC-P1 cells. (1992) (23)
The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps (1989) (23)
Conviction by genetics (1992) (22)
Germline EPHB2 Receptor Variants in Familial Colorectal Cancer (2008) (21)
Distinct Phosphotyrosine-dependent Functions of the ShcA Adaptor Protein Are Required for Transforming Growth Factor β (TGFβ)-induced Breast Cancer Cell Migration, Invasion, and Metastasis* (2012) (21)
The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner (2014) (21)
SELPHI: correlation-based identification of kinase-associated networks from global phospho-proteomics data sets (2015) (21)
EphB receptor activity suppresses colorectal cancer progression (vol 435, pg 1126, 2005) (2005) (20)
Construction of an SH2 Domain-binding Site with Mixed Specificity (*) (1995) (20)
The Shb signalling scaffold binds to and regulates constitutive signals from the Epstein–Barr virus LMP2A membrane protein (2007) (19)
Engineering the Recruitment of Phosphotyrosine Binding Domain-containing Adaptor Proteins Reveals Distinct Roles for RET Receptor-mediated Cell Survival* (2006) (19)
Mapping physical interactions within chromatin by proteomic approaches (2012) (18)
Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila. (2013) (18)
Fine Tuning of the Threshold of T Cell Selection by the Nck Adapters (2010) (17)
Signal transduction and growth control in normal and cancer cells. (1994) (17)
Identification of a Novel Protein Interaction Motif in the Regulatory Subunit of Casein Kinase 2 (2013) (17)
Splice-Mediated Motif Switching Regulates Disabled-1 Phosphorylation and SH2 Domain Interactions (2012) (17)
SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells (2014) (16)
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice. (2004) (16)
'W' mutant forms of the Fms receptor tyrosine kinase act in a dominant manner to suppress CSF-1 dependent cellular transformation. (1993) (16)
The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression. (2013) (16)
Structure and phosphorylation of the Fujinami sarcoma virus gene product (1981) (16)
How is SOS activated? Let us count the ways (2008) (16)
Biochemical analysis of SH2 domain-mediated protein interactions. (1995) (15)
The Adaptor Protein Grb2 Is Not Essential for the Establishment of the Glomerular Filtration Barrier (2012) (15)
Monoclonal antibodies to the transforming protein of Fujinami avian sarcoma virus discriminate between different fps-encoded proteins (1984) (15)
Selection of recombinant anti‐SH3 domain antibodies by high‐throughput phage display (2015) (15)
Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. (2015) (15)
Modulated adhesion: a proposal for the role of myelin-associated glycoprotein in myelin wrapping. (1989) (15)
Src Homology 2 Domain Containing Protein 5 (SH2D5) Binds the Breakpoint Cluster Region Protein, BCR, and Regulates Levels of Rac1-GTP* (2014) (14)
Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain (2010) (14)
Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution” (2011) (14)
Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling (2013) (14)
Look at a tyrosine kinase (1994) (14)
Cell Signalling - The Proteomics of It All (2001) (13)
Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site (1999) (13)
Opposite effects of the p 52 shc / p 46 shc and p 66 shc splicing isoforms on the EGF receptor – MAP kinase – fos signalling pathway receptor (2013) (13)
Binding of SH 2 Domains of Phospholipase C γ 1 , GAP , and Src to Activated Growth Factor Receptors (2005) (13)
Abnormal mesoderm patterning in mouse embryos mutant for the SH 2 tyrosine phosphatase Shp-2 which comprise a large family of transmembrane and (1997) (13)
Construction and expression of linker insertion and site-directed mutants of v-fps protein-tyrosine kinase. (1991) (12)
Grb2 regulates the proliferation of hematopoietic stem and progenitors cells. (2017) (12)
CoreFlow: a computational platform for integration, analysis and modeling of complex biological data. (2014) (11)
Regulation of the Ras signalling pathway by protein-tyrosine kinases. (1994) (11)
Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. (2009) (11)
Progressive cardiac fibrosis and myocyte injury in v-fps transgenic mice. A model for primary disorders of connective tissue in the heart? (1991) (11)
Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer. (2018) (10)
Rapid and sensitive MRM‐based mass spectrometry approach for systematically exploring ganglioside‐protein interactions (2013) (10)
v-fps protein-tyrosine kinase coordinately enhances the malignancy and growth factor responsiveness of pre-neoplastic lung fibroblasts. (1988) (10)
Albumin decrease is associated with spontaneous preterm delivery within 48 h in women with threatened preterm labor. (2015) (10)
Nck1 deficiency accelerates unloading‐induced bone loss (2013) (10)
The football managers (1973) (10)
Correspondence between immunological and functional domains in the transforming protein of Fujinami sarcoma virus (1985) (9)
Discoidin Domain Receptor 1 Is Activated Independently of b 1 Integrin* (2000) (9)
Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90 (2016) (9)
Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok (2008) (8)
Syk tyrosine kinase required for mouse viability and B-cell development (1996) (8)
Deletion of Exon I of SMAD 7 in Mice Results in Altered B Cell Responses (2006) (8)
Transcription factors as oncogenes (1987) (8)
The synthesis and degradation of ras-related gene products during growth and differentiation in Dictyostelium discoideum. (1987) (7)
Modifications of tumor histology by point mutations in the v-fps oncogene: possible role of extracellular matrix. (1987) (7)
Twisted amide electrophiles enable cyclic peptide sequencing. (2015) (7)
Erratum: Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the β receptor subunit (Oncogene (1995) 10 (907-917)) (1995) (7)
Signal transduction. Look at a tyrosine kinase. (1994) (7)
Dexamethasone effects on induction of neoplastic transformation by Fujinami sarcoma virus in an in vitro chick embryo periosteal model for osteosarcoma. (1988) (7)
HDX-MS takes centre stage at unravelling kinase dynamics. (2014) (7)
Zap 70 Tyrosine 315 Mediated by Lck-Dependent Phosphorylation the Zap 70 Protein Tyrosine Kinase Is T Cell Activation-Induced CrkII Binding to and Noah (2005) (6)
Mutational Activation ofc-raf-1 andDefinition oftheMinimal Transforming Sequence (1990) (6)
Neoplastic transformation of osteogenic cells: quantitative morphometric analysis of an in vitro model for osteosarcoma. (1988) (6)
Multivalent nephrin–Nck interactions define a threshold for clustering and tyrosine-dependent nephrin endocytosis (2020) (6)
Proteins suggest form of their own database (2000) (6)
The evolution of protein phosphorylation. Preface. (2012) (6)
GTPase-Activating Protein (2020) (6)
Cell migration by a FRS2‐adaptor dependent membrane relocation of ret receptors (2008) (5)
A RAS‐encoded protein in Dictyostelium discoideum is acylated and membrane‐associated (1987) (5)
Modular Protein Interaction Domains in Cellular Communication (2010) (5)
Biochemistry of the cancer cell. (1990) (5)
The SH2 Domain: A Prototype for Protein Interaction Modules (2008) (4)
Systematic Characterization of RhoGEF/RhoGAP Regulatory Proteins Reveals Organization Principles of Rho GTPase Signaling (2018) (4)
EphB activity suppresses colorectal cancer progression (2005) (4)
Expression of viral p21ras during acquisition of a transformed phenotype by rat adrenal cortex cells infected with Kirsten murine sarcoma virus (1986) (4)
Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins (2018) (4)
The evolution of protein phosphorylation (2016) (4)
Q & A. Interview. (2003) (4)
Nck adaptor proteins modulate differentiation and effector function of T cells (2015) (4)
Localization and characterization of phosphorylation sites of the fujinami avian sarcoma virus and prcii virus transforming proteins (1982) (4)
Crystal structure of the Sec 4 p : Sec 2 p complex in the nucleotide exchanging intermediate state (2008) (4)
Cell Communication: The Inside Story.: The Inside Story. (2000) (3)
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring (2019) (3)
Multivalent nephrin/Nck interactions define a threshold for clustering and tyrosine-dependent nephrin endocytosis. (2020) (3)
Supplementary Materials for Linear Motif Atlas for Phosphorylation-Dependent Signaling (2008) (3)
Growth Factors, Oncogenes, and Breast Cancer (1987) (3)
TheFps/Fes Protein-Tyrosine KinasePromotes Angiogenesis inTransgenic Mice (1994) (2)
Abstract 2324: RhoGTPase-based regulation of cell motility by Plk4. (2013) (2)
Bacterial expression, purification and preliminary kinetic description of the kinase domain of v-fps. (1995) (2)
CHAPTER 67 – Modular Protein Interaction Domains in Cellular Communication (2003) (1)
A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts (2012) (1)
Protein phosphorylation goes negative. (2009) (1)
Diverse Genetic Backgrounds Phosphorylation Networks Regulating JNK Activity (2008) (1)
Cell signalling. Conviction by genetics. (1992) (1)
Identification of a Novel Protein Interaction Motif in the Regulatory Subunit of Protein 1 (2013) (1)
Corrigendum: EphB receptor activity suppresses colorectal cancer progression (2005) (1)
The Bcr-Abl SH2-Kinase Domain Interface Is Critical for Leukemogenesis and An Additional Therapeutic Target in CML. (2009) (1)
Supplemental Data High-Throughput Phosphotyrosine Profiling Using SH 2 Domains (2007) (1)
Structure-function relationships in cellular and viral fps/fes cytoplasmic protein-tyrosine kinases. (1988) (1)
Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy (2002) (1)
Protein Interaction Domains Assembly of Cell Regulatory Systems Through (2008) (1)
She proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases ( Src homology 2 domain / transformatlon / tyrosine phosphorylation ) (2004) (1)
Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker (2009) (0)
Metabolism The Adaptor Protein p 66 Shc Inhibits mTOR-Dependent Anabolic ` (2014) (0)
METHODS USEFUL IN MODULATING PROTEIN TYROSINE PHOSPHATASES (2017) (0)
Multiple cDNAsEncoding theeskKinase Predict Transmembrane andIntracellular EnzymeIsoforms (1992) (0)
Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex (2003) (0)
Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring (2021) (0)
STRUCTURE-FUNCTION RELATIONSHIPS IN CELLULAR AND VIRAL fps/fes (1988) (0)
SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN (2000) (0)
Clk: Cdc28-like kinase (vertebrates) (Serine/threonine/tyrosine kinase, Sty) (1995) (0)
Fes kinase structure reveals cooperative interactions between SH2-kinase domains and substrate (2008) (0)
Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions (2020) (0)
252: RhoGTPase-based regulation of cell spreading by Plk4 (2014) (0)
Chapter 11 – Signal Transduction by Growth Factor Receptors (2008) (0)
Getting a Line on Human Diseases. (2000) (0)
SOLUTION STRUCTURE OF THE NUMB PTB DOMAIN COMPLEXED TO A NAK PEPTIDE (2000) (0)
Nck proteins are recruited directly to the BCR and regulate PI3K signaling thereby shaping B cell immune responses (P1154) (2013) (0)
Crystal Structure of the EphB2 Receptor Kinase domain in complex with ADP (2007) (0)
NMR structure of the Saccharomyces cerevisiae Ste50 SAM domain (2006) (0)
Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis (2002) (0)
SRC SH2 THREF1TRP MUTANT (2000) (0)
Cellular oncogene activation: edited by George Klein, Marcel Dekker, 1988. $110.00 (USA and Canada), $132.00 (elsewhere) (xv + 396 pages) ISBN 0 8247 7983 5 (1989) (0)
PTB do iE a new protehl mp kaed in signg tr uctio11 (1995) (0)
Structural Requirements forEnhancement ofT-Cell Responsiveness bytheLymphocyte-Specific Tyrosine Protein Kinasep561ck (1992) (0)
74 The growing family of eph receptors and their function in brain development (1996) (0)
TheSteellW Transduction Pathway: KitAutophosphorylation and ItsAssociation withaUniqueSubset ofCytoplasmic Signaling Proteins IsInduced bytheSteel Factor (1991) (0)
Crystal structure of a mutant EphA4 kinase domain (Y742A) (2007) (0)
Thev-SrcSH3DomainBindsPhosphatidylinositol 3'-Kinase (1993) (0)
Nek1: NimA-related kinase (vertebrates) (1995) (0)
Protein interaction domains and biological complexity (2006) (0)
The Dynactome-investigating dynamic network motifs of kinasess (2007) (0)
HighIncidence ofLung,Bone,andLymphoid TumorsinTransgenic MiceOverexpressing MutantAlleles ofthep53Oncogene (1989) (0)
Determinants of specificity in phosphoprotein/ SH2 domain interactions (1994) (0)
Correspondence BetweenImmunological andFunctional Domainsin theTransforming Protein ofFujinami SarcomaVirus (1985) (0)
Tony Pawson OC OOnt CH FRS FRSC (2013) (0)
Tyrosine kinases to Ras (1993) (0)
ArhGAP9 PH domain in complex with Ins(1,4,5)P3 (2007) (0)
Regulation of nucleo/cytoplasmic shuttling of Bruton's (2012) (0)
This information is current as Selection by the Nck Adapters Fine Tuning of the Threshold of T Cell (2010) (0)
Metazoan Evolution ' ' Response to Comment on ' ' Positive Selection of Tyrosine Loss in (2012) (0)
SAP/SH2D1A bound to peptide n-pY (2001) (0)
Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain (2003) (0)
Methods in Protein Structural Analysis 2006 Posttranslational modifications : analysis and function (2006) (0)
Inhibition of EphA2 receptor tyrosine kinase activity by dasatinib in pancreatic cancer. (2007) (0)
dNumb PTB Domain Complexed with a Phosphotyrosine Peptide, NMR, Ensemble of Structures. (1999) (0)
Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring (2021) (0)
Phosphotyrosine signaling: a prototype for modular protein‐protein interactions (2007) (0)
THE DYNACTOME: INVESTIGATING DYNAMIC KINASE NETWORKS IN CELLULAR DECISION-MAKING (2008) (0)
TheHumanc-fpslfes GeneProduct Expressed Ectopically inRat Fibroblasts IsNontransforming andHasRestrained Protein-Tyrosine Kinase Activity (1988) (0)
Science Signaling Pawson and Rune Linding ( 28 July 2009 ) (2009) (0)
Table of Contents (1996) (0)
Elk (2022) (0)
Decoding the functional Fes kinase signaling network topology in a lymphocyte model (2020) (0)
Screening for PTB Domain Binding Partners and Ligand Speciﬁcity Using Proteome-Derived NPXY Peptide Arrays (cid:1) † (2006) (0)
Signaling Networks— Minireview Do All Roads Lead to the Same Genes? (1999) (0)
Vagaries of Vav Vav, a protein that contains an intriguing array of motifs, participates in the signaling pathways of distinct hematopoietic receptors and may represent a new class of signal transducing molecules. (1992) (0)
Supplementary Information Construction of Human Activity-Based Phosphorylation Networks (2013) (0)
Mechanisms of Kinase-Phosphatase Interactions Protein Interaction Network of the Mammalian Hippo Pathway Reveals ` (2013) (0)
Protein interactions in cellular signaling (2005) (0)
ArhGAP9 PH domain in complex with Ins(1,3,4)P3 (2007) (0)
A BIOLOGICAL RATIONALE FOR THE EVOLUTION AND EXPANSION OF PHOSPHO-BINDING DOMAINS (2012) (0)
Tyrosine kinase and their interactions with signalling proteins (1992) (0)
THE HUMAN COMPLEMENT OF SH 2 DOMAIN PROTEINS (2005) (0)
Oncogenes and growth control edited by Patricia Kahn and Thomas Graf, Springer-Verlag, 1986.DM 148 (xxi + 369 pages) ISBN 3 540 16839 7 (1987) (0)
Table of Contents (1996) (0)
100 and 50 years ago (1997) (0)
A Web Resource for Improved Analysis of AP-MS Protein Interaction Data. (2013) (0)
Abstract 5298: ShcA Phosphotyrosine-Derived Signaling is Required for Maintenance of Cardiac Function (2008) (0)
No major change in apoptosis or proliferation in Yap mutant kidneys. (2013) (0)
Science Signaling Podcast: 24 November 2009 (2009) (0)
Cancer esearch oenvironment and Immunology eptor Tyrosine Kinase Signaling Favors a Protumorigenic te in Breast Cancer Cells by Inhibiting the Adaptive R une Response (2010) (0)
ArhGAP9 PH domain in complex with Ins(1,3,5)P3 (2007) (0)
Origin of plasmocytoma cells (1974) (0)
The Fes tyrosine kinase guides CD19 receptor fate in B-cells by shaping regulatory Src phosphorylation networks (2017) (0)
Modular Protein-Protein Interactions Provide a General Mechanism to Organize Dynamic Cellular Systems (2010) (0)
DBL homology domain from beta-PIX (1999) (0)
SH2 Domains of the p85cx Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors (0)
Gareth Edwards on fishing (1984) (0)
Abstract 322: Distinct pools of ShcA coupled tyrosine kinase signaling influences breast tumor heterogeneity and therapeutic responsiveness (2017) (0)
eptor Tyrosine Kinase Signaling Favors a Protumorigenic te in Breast Cancer Cells by Inhibiting the Adaptive (2010) (0)
virus.infected with Kirsten murine sarcoma a transformed phenotype by rat adrenal cortex Expression of viral p21ras during acquisition of (2013) (0)
Kinase and Ubiquitin-associated domains of MARK3/Par-1 (2007) (0)
receptor tyrosine kinase . Characterization of elk , a brain-specific (2003) (0)
Elk: Elk receptor tyrosine kinase (vertebrates) (1995) (0)
Myelin-Associated Glycoprotein, aCellAdhesion Molecule of Oligodendrocytes, IsPhosphorylated inBrain (1988) (0)
Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region (2001) (0)
Dispatch MAPK Signaling: Sho Business (2004) (0)
Mammalian-Membrane-Two-Hybrid ( MaMTH ) : a novel split-ubiquitin assay for investigation of signaling pathways in human cells (2014) (0)

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