Antoine Hakim
#79,057
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Neurologist
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Antoine Hakimmedical Degrees
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#1265
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#1587
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Neurology
#182
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#253
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Antoine Hakim's Degrees
- PhD Neuroscience McGill University
Why Is Antoine Hakim Influential?
(Suggest an Edit or Addition)According to Wikipedia, Antoine M. Hakim is a Canadian engineer and physician. He first trained as a chemical engineer and worked for Syncrude in Alberta. Wishing to change careers, Hakim taught school for a short time in Montreal. He then earned a PhD in Biomedical Engineering from Rensselaer Polytechnic Institute in New York and went on to study medicine at Albany Medical College. He completed his residency at the Montreal Neurological Institute and later became a professor at McGill University. In 1992, he became chair of the Neurology department and director of the Neuroscience Research Institute at the University of Ottawa. From 1992 to 2000, he was head of the Neurology division at The Ottawa Hospital.
Antoine Hakim's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Toward Wisdom From Failure: Lessons From Neuroprotective Stroke Trials and New Therapeutic Directions (2002) (644)
- Microparticles: biomarkers and beyond. (2013) (308)
- Dementia in Parkinson disease (1979) (304)
- Cyclin-dependent kinases as a therapeutic target for stroke. (2000) (272)
- Anatomical-Functional Correlation Using an Adjustable MRI-Based Region of Interest Atlas with Positron Emission Tomography (1988) (268)
- Immediate anticoagulation of embolic stroke: brain hemorrhage and management options. Cerebral Embolism Study Group. (1984) (265)
- Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus (1997) (257)
- Nestin expression in reactive astrocytes following focal cerebral ischemia in rats (1997) (215)
- APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death (2001) (207)
- The association of hyperglycemia with cerebral edema in stroke. (1986) (198)
- Living beyond our physiological means: small vessel disease of the brain is an expression of a systemic failure in arteriolar function: a unifying hypothesis. (2009) (190)
- The Cerebral Ischemic Penumbra (1987) (185)
- Heart disease as a risk factor for dementia (2013) (170)
- Characterization of Stanniocalcin 2, a Novel Target of the Mammalian Unfolded Protein Response with Cytoprotective Properties (2004) (169)
- Cortical Spreading Depression Protects against Subsequent Focal Cerebral Ischemia in Rats (1996) (168)
- Attention modulates somatosensory cerebral blood flow response to vibrotactile stimulation as measured by positron emission tomography (1991) (146)
- The effect of spontaneous reperfusion on metabolic function in early human cerebral infarcts (1987) (146)
- The Effect of Nimodipine on the Evolution of Human Cerebral Infarction Studied by PET (1989) (143)
- Transient forebrain ischemia protects against subsequent focal cerebral ischemia without changing cerebral perfusion. (1995) (136)
- Age Disparities in Stroke Quality of Care and Delivery of Health Services (2009) (124)
- ATP release by way of connexin 36 hemichannels mediates ischemic tolerance in vitro. (2008) (121)
- Cerebral Vulnerability Is Associated with Selective Increase in Extracellular Glutamate Concentration in Experimental Thiamine Deficiency (1993) (116)
- Cortical spreading depression activates trophic factor expression in neurons and astrocytes and protects against subsequent focal brain ischemia (1998) (111)
- Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance after Global Ischemia in the Rat (2002) (110)
- Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance (2007) (100)
- Calcium‐Mediated Mechanisms of Ischemic Injury and Protection (1994) (98)
- Primary prevention of stroke: blood pressure, lipids, and heart failure. (2011) (87)
- Hippocampal Myc and p53 expression following transient global ischemia. (1998) (85)
- Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum. (1988) (84)
- Cerebral Acidosis in Focal Ischemia: II. Nimodipine and Verapamil Normalize Cerebral pH following Middle Cerebral Artery Occlusion in the Rat (1986) (76)
- Sequential computerized tomographic appearance of strokes. (1983) (75)
- The Effects of a Competitive NMDA Receptor Antagonist (CGS-19755) on Cerebral Blood Flow and pH in Focal Ischemia (1991) (73)
- Hemodynamic and metabolic effects of cerebral revascularization. (1987) (73)
- Effect of Vascular Activity in the Determination of Rate Constants for the Uptake of 18F-Labeled 2-Fluoro-2-Deoxy-D-Glucose: Error Analysis and Normal Values in Older Subjects (1986) (66)
- Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice (2001) (59)
- Autoradiographic Determination of Brain pH Following Middle Cerebral Artery Occlusion in the Rat (1984) (59)
- Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart (1999) (58)
- Time Course of Cerebral Blood Flow and Histological Outcome After Focal Cerebral Ischemia in Rats (1992) (58)
- Preeclampsia Is a Biomarker for Vascular Disease in Both Mother and Child: The Need for a Medical Alert System (2013) (57)
- Apoptosis is restricted to the thalamus in thiamine-deficient rats. (1997) (54)
- Reduction of Functional Capillary Density in Human Brain after Stroke (1990) (53)
- Hemodynamic and metabolic effects of cerebral arteriovenous malformations studied by positron emission tomography. (1989) (48)
- Subtle neuronal death in striatum after short forebrain ischemia in rats detected by in situ end-labeling for DNA damage. (1997) (46)
- Depression, dementia and immune dysregulation. (2020) (45)
- Distribution of neuronal apoptosis inhibitory protein‐like immunoreactivity in the rat central nervous system (1997) (43)
- Calcium channel blockers correct acidosis in ischemic rat brain without altering cerebral blood flow. (1988) (43)
- A Physiological Approach to Clinical Neurology. (1982) (42)
- In vivo Binding of Nimodipine in the Brain: I. The Effect of Focal Cerebral Ischemia (1991) (42)
- Regulation of nestin expression after cortical ablation in adult rat brain (2004) (38)
- Pre Admission Antithrombotics are Associated with Improved Outcomes following Ischaemic Stroke: A Cohort from the Registry of the Canadian Stroke Network (2009) (38)
- Apoptosis Occurs in the Penumbra Zone during Short-Duration Focal Ischemia in the Rat (2003) (38)
- Nimodipine Prevents Hyperglycemia-Induced Cerebral Acidosis in Middle Cerebral Artery Occluded Rats (1989) (36)
- Organized stroke care: A new era in stroke prevention and treatment (1998) (36)
- Metabolic and Histological Reversibility of Thiamine Deficiency (1983) (34)
- Estimation of Cerebral Oxygen Utilization Rate by Single-Bolus 15O2 Inhalation and Dynamic Positron Emission Tomography (1987) (33)
- Cortical spreading depression modifies components of the inflammatory cascade (2005) (33)
- C-reactive protein expression in a rodent model of chronic cerebral hypoperfusion (2011) (33)
- Cilostazol reduces blood brain barrier dysfunction, white matter lesion formation and motor deficits following chronic cerebral hypoperfusion (2016) (32)
- BASIS OF DEMENTIA IN PARKINSON'S DISEASE (1978) (31)
- Transient expression of GAP-43 within the hippocampus after global brain ischemia in rat (1997) (30)
- Effect of Thiamine Deficiency and its Reversal on Cerebral Blood Flow in the Rat. Observations on the Phenomena of Hyperperfusion, “No Reflow,” and Delayed Hypoperfusion (1986) (30)
- Microparticles generated during chronic cerebral ischemia increase the permeability of microvascular endothelial barriers in vitro (2016) (29)
- Ischemia-induced CA1 neuronal death is preceded by elevated FosB and Jun expression and reduced NGFI-A and JunB levels. (1998) (28)
- Small Vessel Disease (2019) (27)
- Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP (2006) (26)
- Could transient ischemic attacks have a cerebroprotective role? (1994) (26)
- Hemodynamic and Metabolic Effects of Extracranial Carotid Disease (1989) (26)
- Depression, Strokes and Dementia: New Biological Insights into an Unfortunate Pathway (2011) (25)
- In Vivo Distribution of CGS‐19755 Within Brain in a Model of Focal Cerebral Ischemia (1992) (25)
- Microparticles generated during chronic cerebral ischemia deliver proapoptotic signals to cultured endothelial cells. (2014) (24)
- Reversibility of Nimodipine Binding to Brain in Transient Cerebral Ischemia (1992) (22)
- Stroke Prevention and Cognitive Reserve: Emerging Approaches to Modifying Risk and Delaying Onset of Dementia (2013) (22)
- APAF 1 is a key transcriptional target for p 53 in the regulation of neuronal cell death (2001) (21)
- Cortical spreading depression transiently activates MAP kinases. (2002) (21)
- Immunomodulation strategies for preventing vascular disease of the brain and heart: workshop summary. (2006) (20)
- In vivo Binding of Nimodipine in the Brain: II. Binding Kinetics in Focal Cerebral Ischemia (1991) (20)
- Relevance of Interstitial Glutamate to Selective Vulnerability in Focal Cerebral Ischemia (1994) (19)
- Effect of Nimodipine on the Regional Cerebral Acidosis Accompanying Thiamine Deficiency in the Rat (1988) (19)
- Regional activation of L‐type voltage‐sensitive calcium channels in experimental thiamine deficiency (1998) (18)
- Tongue protrusion: a simple test for neurological recovery in rats following focal cerebral ischemia (2003) (18)
- studied by positron emission tomography Hemodynamic and metabolic effects of cerebral arteriovenous malformations (2011) (18)
- Measurement of cerebral blood flow and volume with positron emission tomography during isoflurane administration in the hypocapnic baboon. (1990) (18)
- Local Cerebral Glucose Utilization in Two Models of B12 Deficiency (1983) (16)
- Cerebral Acidosis in Focal Ischemia: I. A Method for the Simultaneous Measurement of Local Cerebral pH with Cerebral Glucose Utilization or Cerebral Blood Flow in the Rat (1986) (16)
- The Neuron : Cell and Molecular Biology, 2nd edition (1999) (16)
- PET Metabolic and Neuropsychological Correlates of Periventricular Lucencies (1991) (15)
- Cerebral acidosis in focal ischemia. (1989) (15)
- Vascular disease: the tsunami of health care. (2007) (15)
- Relationship between Extracellular Glutamate Concentration and Voltage-Sensitive Calcium Channel Function in Focal Cerebral Ischemia in the Rat (1996) (14)
- Is Canada falling behind international standards for stroke care? (1998) (14)
- The Management of Hypertension for Primary Stroke Prevention: A Proposed Approach (2011) (13)
- Use of calcium channel blockers after stroke is not associated with poor outcome (2006) (11)
- Animal Models of Cerebral Ischemia. 2. Rat Models (1991) (11)
- The effects of high- and low-risk environments on cognitive function in rats following 2-vessel occlusion of the carotid arteries: A behavioral study (2013) (11)
- In vivo Binding of [3H]Nimodipine in Rat Brain after Transient Forebrain Ischemia (1994) (11)
- Focal Flow Disturbances in Acute Strokes: Effects on Regional Metabolism and Tissue pH (1985) (10)
- In vivo quantification of blood‐brain transfer and binding of [125I]HEAT, an α1‐adrenoceptor antagonist (1989) (10)
- Nimodipine Binding in Focal Cerebral Ischemia (1990) (10)
- Immediate-early gene expression in the brain of the thiamine-deficient rat (2007) (10)
- Genes and Cerebral Ischemia Therapeutic Perspectives (1996) (9)
- Regional cerebral glucose metabolism differs in adult and rigid juvenile forms of Huntington disease. (1989) (8)
- A Proposed Hypothesis on Dementia: Inflammation, Small Vessel Disease, and Hypoperfusion Is the Sequence That Links All Harmful Lifestyles to Cognitive Impairment (2021) (7)
- Protection conferred by Corticotropin-releasing hormone in rat primary cortical neurons against chemical ischemia involves opioid receptor activation (2009) (7)
- In Vivo Uptake of [3H]Nimodipine into Brain during Cortical Spreading Depression (1997) (6)
- In Vitro Binding of [3H]Nimodipine and [3H]CGS-19755 to Rat Brain in Focal Cerebral Ischemia (1995) (6)
- Effect of Folate Deficiency on Local Cerebral Glucose Utilization in the Rat (1984) (4)
- Cervical Artery Dissection is Associated with Widened Aortic Root Diameter (1998) (3)
- A regulated environmental perfusion system for the study of anoxic or hypoxic cultured neurons using microfluorescence imaging and electrophysiology (1998) (3)
- Perspective: Silent, but preventable, perils (2014) (3)
- Density of Functioning Cerebral Capillaries in Stroke Patients, Determined by PET (1989) (2)
- Alpers and Mancall's Essentials of the Neurologic Examination (1982) (2)
- Cortical Metabolic Dysfunction in a Mitochondrial Encephalomyopathy (MERRF) Demonstrated by Positron Emission Tomography (1987) (2)
- Activity of the dihydropyridine calcium channels following cerebral ischemia. (1991) (2)
- Patterns of physiological and biochemical changes in acute human cerebral infarction with and without hyperglycemia studied by positron emission tomography. (1988) (1)
- rtPA in acute stroke patients with history of cognitive impairment (2014) (1)
- t-PA: A Cause for Tentative Celebration (1998) (1)
- Nimodipine Binding in Cerebral Ischemia (1989) (1)
- Capillary Density in Stroke Regions of the Living Human Brain (1988) (1)
- Ischemic Preconditioning: Introduction (2004) (1)
- [Cerebral blood flow, cerebral oxygen metabolism, cerebral glucose metabolism, and tissue pH in human acute cerebral infarction using positron emission tomography]. (1985) (1)
- CORTICAL ABLATION UP-REGULATES NESTIN EXPRESSION IN ADULT MAMMALIAN BRAIN (2000) (0)
- INVESTIGATION OF APOPTOSIS IN SHORT-DURATION FOCAL ISCHEMIA IN THE RAT (2000) (0)
- THE RELATIONSHIP BETWEEN rCBF, BRAIN pH ADN DNA CLEAVAGE IN TRANSIENT FOCAL CEREBRAL ISCHEMIA (2000) (0)
- Expression of Nuclear Orphan Receptors Ngfi-B/Tr3, Nurr1 And Nor-1 after Global Brain Ischemia in Rat (2001) (0)
- CJN volume 27 issue S1 Cover and Front matter (2000) (0)
- Contemporary Approaches to Cerebrovascular Disease (1988) (0)
- Metabolic mapping of speech with fluorine 18 fluorodeoxyglucose and positron emission tomography (1987) (0)
- The Tsunami of Health Care (2007) (0)
- Endothelial Ectosomes and the Progression of Small Vessel Disease (2013) (0)
- Field of View for Gamma Ray Detectors and Extended Radiation Sources (1988) (0)
- REVIEW Depression, dementia and immune dysregulation (2021) (0)
- Adenosine deaminase: A novel marker of T-helper lymphocytes (CD4+) in active pulmonary tuberculosis (1994) (0)
- Clinical Examinations in Neurology (1982) (0)
- Gene and cell therapy in stroke (2003) (0)
- Silent, but preventable, perils (2014) (0)
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