Antonı́n Holý
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(Suggest an Edit or Addition)Antonı́n Holý's Published Works
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Published Works
- A novel selective broad-spectrum anti-DNA virus agent (1986) (732)
- Acyclic nucleoside phosphonates: a key class of antiviral drugs (2005) (598)
- Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. (1987) (469)
- Regulation of ribosomal RNA promoters with a synthetic lac operator. (1984) (415)
- Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine (1993) (329)
- Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents (1988) (245)
- (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication (1988) (224)
- Phosphonomethoxyalkyl analogs of nucleotides. (2003) (190)
- Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. (1989) (187)
- 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. (1991) (176)
- Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. (2000) (173)
- Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection (2006) (168)
- Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues (2005) (148)
- Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. (1999) (146)
- Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. (1990) (133)
- 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. (2002) (130)
- Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection. (1993) (117)
- Synthesis of 9-(2-Phosphinomethoxyethyl)adenine and Related Compounds (1987) (115)
- Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon. (1996) (110)
- Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. (2009) (98)
- Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. (1995) (97)
- 5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. (2003) (93)
- Antivaccinia Activities of Acyclic Nucleoside Phosphonate Derivatives in Epithelial Cells and Organotypic Cultures (2002) (91)
- 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. (1991) (89)
- Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. (1996) (89)
- Antiviral activity of aliphatic nucleoside analogues: structure-function relationship. (1979) (83)
- Cytostatic 6-Arylpurine Nucleosides III. Synthesis and Structure-Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl- and 6-Benzylpurine Ribonucleosides (2001) (81)
- Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. (2009) (81)
- Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice (1991) (80)
- Broad-spectrum antiviral activity of adenosine analogues. (1984) (79)
- Synthetic reactions of dimethylformamide. XIII. β-Bromoacraldehydes (1961) (75)
- Metal-ion-coordinating properties of various phosphonate derivatives, including 9-[2-(phosphonylmethoxy(ethyl]adenine (PMEA)- an adenosine monophosphate (AMP) analogue) with antiviral properties (1992) (75)
- Antiviral acyclic nucleoside phosphonates structure activity studies. (2006) (70)
- ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES (2005) (70)
- Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity. (1996) (66)
- Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates (2002) (64)
- Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds. (2004) (63)
- Preparation of N-dimethylaminomethylene derivatives - A new method of a selective substitution of nucleoside amino groups (1967) (63)
- Preparation of 5'-O-phosphonylmethyl analogues of nucleoside-5'-phosphates, 5'-diphosphates and 5'-triphosphates (1982) (62)
- Nucleic acid components and their analogues. CLIII. Preparation of 2'-deoxy-L-ribonucleosides of the pyrimidine series (1972) (61)
- Aliphatic analogues of nucleosides, nucleotides, and oligonucleotides (1975) (60)
- Biogenic amine formation by poultry‐associated spoilage and pathogenic bacteria (1995) (60)
- Inhibition of S-adenosyl-L-homocysteine hydrolase by the aliphatic nucleoside analogue - 9-( S )-(2,3-dihydroxypropyl)adenine (1980) (59)
- A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities. (2011) (58)
- Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents. (1985) (58)
- Evaluation of Nucleoside Phosphonates and Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication (2003) (57)
- Antiviral Activity of Triazine Analogues of 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) and Related Compounds (2007) (56)
- Syntheses of Enantiomeric N -(3-Hydroxy-2-phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases (1993) (54)
- Interaction of Escherichia coli EF-Tu.GTP and EF-Tu.GDP with analogues of the 3' terminus of aminoacyl-tRNA. (1980) (53)
- Synthesis of N-(2-phosphonylmethoxyethyl) derivatives of heterocyclic bases (1989) (52)
- Specificity of purine nucleoside phosphorylase from Escherichia coli (1977) (51)
- Synthesis and cytostatic activity of n-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, 2,6-diaminopurines and related compounds (2001) (51)
- Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, interferon, and bropirimine (1992) (50)
- Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. (2007) (50)
- Metabolism of 1-( S )-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine (HPMPC) in Human Embryonic Lung Cells (1992) (49)
- Inhibitory Effects of Novel Nucleoside and Nucleotide Analogues on Epstein—Barr Virus Replication (1998) (49)
- Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates. (1994) (48)
- Synthesis and antiviral activity of stereoisomeric eritadenines (1982) (48)
- Activities of Several Classes of Acyclic Nucleoside Phosphonates against Camelpox Virus Replication in Different Cell Culture Models (2007) (47)
- Synthesis of isomeric and enantiomeric O-phosphonylmethyl derivatives of 9-(2,3-dihydroxypropyl)adenine (1987) (47)
- Sequence‐specific hypomethylation of the tobacco genome induced with dihydroxypropyladenine, ethionine and 5‐azacytidine (1994) (45)
- Activation by 9-(R)-[2-(Phosphonomethoxy)Propyl]Adenine of Chemokine (RANTES, Macrophage Inflammatory Protein 1α) and Cytokine (Tumor Necrosis Factor Alpha, Interleukin-10 [IL-10], IL-1β) Production (2001) (45)
- Activity of 9-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine against Schistosomiasis mansoni in Mice (2003) (45)
- Oligonucleotidic compounds. XXXIV. Preparation of some β-L-ribonucleosides, their 2'(3')-phosphates and 2',3'-cyclic phosphates (1969) (44)
- Synthetic reactions of dimethylformamide. XIV. Some new findings on adducts of the Vilsmeier-Haack type (1962) (43)
- In Vitro Activity of 2,4-Diamino-6-[2-(Phosphonomethoxy)Ethoxy]-Pyrimidine against Multidrug-Resistant Hepatitis B Virus Mutants (2007) (42)
- Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities (2005) (42)
- Synthesis of Enantiomeric N -(2-Phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases. II. The Synthon Approach (1995) (41)
- A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists. (2005) (41)
- Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy. (2010) (41)
- N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates. (2006) (39)
- Eritadenines - Novel type of potent inhibitors of S-adenosyl-L-homocysteine hydrolase (1982) (39)
- Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines. (2003) (39)
- Oligonucleotidic compounds. XIV. Synthesis of some diribonucleoside phosphates using the N-dimethylaminomethylene derivatives of 2',3'-O-ethoxymethylene ribonucleosides (1966) (39)
- 6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs. (2011) (38)
- Phosphonylmethoxyalkylpurines and -pyrimidines as inhibitors of African swine fever virus replication in vitro. (1987) (38)
- Activities of Acyclic Nucleoside Phosphonates against Orf Virus in Human and Ovine Cell Monolayers and Organotypic Ovine Raft Cultures (2005) (38)
- Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. (2007) (38)
- Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. (2012) (36)
- Aliphatic analogues of nucleotides: synthesis and affinity towards nucleases. (1974) (36)
- Efficient and ‘green’ microwave-assisted synthesis of haloalkylphosphonates via the Michaelis–Arbuzov reaction (2011) (36)
- Synthesis of (3-hydroxy-2-phosphonylmethoxypropyl) derivatives of heterocyclic bases (1989) (35)
- Mechanism of Antiviral Drug Resistance of Vaccinia Virus: Identification of Residues in the Viral DNA Polymerase Conferring Differential Resistance to Antipoxvirus Drugs (2008) (35)
- Metal ion-binding properties of 1-methyl-4-aminobenzimidazole (=9-methyl-1,3-dideazaadenine) and 1,4-dimethylbenzimidazole (=6,9-dimethyl-1,3-dideazapurine). quantification of the steric effect of the 6-amino group on metal ion binding at the N7 site of the adenine residue. (2001) (35)
- Strain typing in the genus Lactobacillus (1994) (35)
- Transdermal and dermal delivery of adefovir: effects of pH and permeation enhancers. (2008) (35)
- Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome. (1998) (35)
- Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. (1995) (34)
- Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases α, δ, and ε* (2002) (34)
- Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution. (2005) (34)
- Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors. (2010) (33)
- Complex Formation of the Antiviral 9‐[2‐(Phosphonomethoxy)Ethyl]Adenine (PMEA) and of Its N 1, N 3, and N 7 Deaza Derivatives with Copper(II) in Aqueous Solution (1997) (33)
- Antirhinovirus activity of purine nucleoside analogs (1986) (33)
- Benzoyl cyanide--a new benzoylating agent in nucleoside and nucleotide chemistry. (1971) (33)
- Synthesis of Acyclic Nucleotide Analogues Derived from 2-Amino-6- C -substituted Purines via Cross-Coupling Reactions of 2-Amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with Diverse Organometallic Reagents (2000) (32)
- Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in HB611 Cells (1994) (32)
- Synthetic reactions of dimethylformamide. XVIII. Reactivity of methyl groups in polymethinium salts (1963) (32)
- Determination of acid–base dissociation constants of amino‐ and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis (2006) (32)
- The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines (2011) (32)
- Chiral analysis of anti‐acquired immunodeficiency syndrome drug, 9‐(R)‐[2‐(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using β‐CD as chiral selector (2009) (32)
- Solution properties of antiviral adenine-nucleotide analogues. The acid-base properties of 9-(2-(phosphonomethoxy)ethyl)adenine (PMEA) † and of its N1, N3 and N7 deaza derivatives in aqueous solution (1997) (31)
- Synthesis of some 2,3-dihydroxypropyl derivatives of purine bases (1979) (31)
- Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains (2007) (31)
- Structure-activity studies on open-chain analogues of nucleosides: Inhibition of S-adenosyl-L-homocysteine hydrolase and antiviral activity 1. Neutral open-chain analogues (1985) (30)
- Synthesis of N -(3-Fluoro-2-phosphonomethoxypropyl) (FPMP) Derivatives of Heterocyclic Bases (1993) (30)
- Cytostatic 6-Arylpurine Nucleosides II. Synthesis of Sugar-Modified Derivatives: 9-(2-Deoxy-β-D- erythro -pentofuranosyl)-, 9-(5-Deoxy-β-D-ribofuranosyl)- and 9-(2,3-Dihydroxypropyl)-6-phenylpurines (2000) (30)
- Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. (2007) (29)
- Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines. (2009) (29)
- Phosphonylmethyl Analogs of Nucleotides and Their Derivatives: Chemistry and Biology (1987) (29)
- Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs (1993) (28)
- The Acyclic 2,4-Diaminopyrimidine Nucleoside Phosphonate Acts as a Purine Mimetic in HIV-1 Reverse Transcriptase DNA Polymerization* (2010) (28)
- Synthesis of potential prodrugs and metabolites of 9-( S )-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (1987) (27)
- Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco (2011) (27)
- Phosphonylmethoxyalkyl and phosphonylalkyl derivatives of adenine (1988) (27)
- CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES IV + . SYNTHESIS OF 2-SUBSTITUTED 6-PHENYLPURINE RIBONUCLEOSIDES (2002) (27)
- Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates. (1999) (27)
- Efficacy of oral 9‐(2‐phosphonylmethoxyethyl)‐2,6‐diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice (1993) (27)
- Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. (2008) (27)
- Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues (1991) (27)
- Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. (2006) (27)
- A Nuclear Magnetic Resonance Study of Nucleoside Conformation in Solution. The Effect of Structure and Conformation on the Magnetic Nonequivalence of the 5′-Methylene Hydrogens (1974) (27)
- (S)‐9‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)adenine [(S)‐HPMPA]: a purine analogue with trypanocidal activity in vitro and in vivo (1996) (26)
- Estimation of apparent binding constant of complexes of selected acyclic nucleoside phosphonates with β‐cyclodextrin by affinity capillary electrophoresis (2016) (26)
- Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates. (2005) (26)
- Synthesis of Acyclic Adenine 8,N-Anhydronucleosides (2000) (26)
- Regioselective Preparation of N7‐ and N9‐Alkyl Derivatives of N6‐[(Dimethylamino)methylene]adenine Bearing an Active Methylene Group and Their Further Derivatization Leading to α‐Branched Acyclic Nucleoside Analogues (1999) (26)
- Synthesis of triribonucleoside diphosphates with ribonuclease T 1 (1968) (25)
- 6‐[2‐Phosphonomethoxy)Alkoxy]‐2,4‐Diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity (2004) (25)
- Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines. (1999) (25)
- Metal ion-binding properties of 9-(4-phosphonobutyl)adenine (dPMEA), a sister compound of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), and quantification of the equilibria involving four Cu(PMEA) isomers (2000) (25)
- Nucleic acid components and their analogues. CLIV. Nucleoside and nucleotide derivatives of α-uridine, 2'-deoxy-α-uridine and 2'-deoxy-α-cytidine, and their affinity towards nucleolytic enzymes (1973) (25)
- Aspects of the co-ordination chemistry of the antiviral nucleotide analogue, 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) (1999) (25)
- An efficient microwave-assisted synthesis and biological properties of polysubstituted pyrimidinyl- and 1,3,5-triazinylphosphonic acids (2011) (25)
- Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. (2012) (25)
- Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines. (2011) (25)
- Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*. (2002) (24)
- Nucleic acid components and their analogues. CLIX. Synthesis of some 2-pyrimidone nucleosides (1973) (24)
- Oligonucleotide conformations. Optical studies on GpU analogues with modified-uridine residues. (1972) (24)
- Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis. (2004) (24)
- Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir (2006) (24)
- Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production. (1997) (23)
- The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in intact rat hepatocytes. (1984) (23)
- The polarographic behaviour of polymethinium salts (1965) (23)
- Characterization and Treatment of Cidofovir-Resistant Vaccinia (WR Strain) Virus Infections in Cell Culture and in Mice (2005) (23)
- Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7H-purin-8(9H)-one (2000) (23)
- Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position. (2010) (23)
- Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines (1996) (23)
- The utilization of L‐adenosine by mammalian tissues (1971) (23)
- Preparation of some 2'-deoxy-5-fluorouridine derivatives by a direct fluorination (1976) (22)
- Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines. (2005) (22)
- Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus. (1998) (22)
- Phosphorylation of Purine (Phosphonomethoxy)alkyl Derivatives by Mitochondrial AMP Kinase (AK2 Type) from L1210 Cells (2000) (22)
- Coupling of 6-chloropurines with organocuprates derived from grignard reagents: A convenient route to sec and tert 6-alkylpurines (1996) (22)
- Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase. (2007) (22)
- Syntheses of Base and Side-Chain Modified Pyrimidine 1-[2-(Phosphonomethoxy)propyl] Derivatives as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-Lymphoma (2006) (22)
- 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP)--a potential drug against hematological malignancies--induces apoptosis. (1999) (21)
- Synthesis of 2-Deoxy-β-D-ribonucleosides and 2,3-Dideoxy-β-D-pentofuranosides on Immobilized Bacterial Cells (1994) (21)
- Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 5,5- and 6,6-Bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol (2005) (21)
- New prodrugs of Adefovir and Cidofovir (2011) (21)
- Antitumour activity of N6-substituted PMEDAP derivatives against T-cell lymphoma. (2001) (21)
- HUMAN N6-METHYL-AMP/DAMP AMINOHYDROLASE (ABACAVIR 5'-MONOPHOSPHATE DEAMINASE) IS CAPABLE OF METABOLIZING N6-SUBSTITUTED PURINE ACYCLIC NUCLEOSIDE PHOSPHONATES (2008) (21)
- Nucleic acid components and their analogues. CXL. Preparation of 5'-L-ribonucleotides, some of their derivatives, and 2'(3')→5'-homooligo-L-ribonucleotides; coding properties of L-ribonucleoside-containing oligonucleotides (1971) (21)
- Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives. (2006) (21)
- Phosphonylmethoxyalkyl derivatives of purines and pyrimides: A new class of antiviral agents active against both herpesviruses and retroviruses☆ (1987) (21)
- Synthesis of 1-(3-deoxy-beta-D-psicofuranosyl)uracil and related compounds. (1974) (21)
- The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. (2013) (21)
- A Facile Synthesis of 6-Cyanopurine Bases (1995) (21)
- Metabolism of pyrimidine L-nucleosides. (1976) (21)
- Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues (1999) (20)
- S-adenosyl-L-homocysteine hydrolase from mouse leukemic cells: Isolation and properties (1983) (20)
- Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP. (1997) (20)
- Oligonucleotidic compounds. XXXIII. A study on hydrolysis of N-dimethylaminomethylenecytidine, -adenosine, -guanosine, and related 2'-deoxy compounds (1969) (20)
- Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes. (2000) (20)
- Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds. (2004) (20)
- Metal Ion-Binding Properties of the Nucleotide Analogue 1-[2-(Phosphonomethoxy)ethyl]cytosine (PMEC) in Aqueous Solution (1999) (20)
- 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases α, δ, ε, and ε∗ (1999) (20)
- Use of Pd-catalyzed Suzuki–Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase (2009) (20)
- Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species. (2008) (20)
- 5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production (2014) (19)
- Syntheses of Pyrimidine Acyclic Nucleoside Phosphonates as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-Lymphoma (2007) (19)
- Embryotoxicity of 9-(S)-(2,3-dihydroxypropyl)adenine. (1981) (19)
- Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes. (2003) (19)
- 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-moloney murine sarcoma virus activity in vivo (1989) (19)
- Preparation of 2-pyrimidinone nucleosides from uracil nucleosides (1977) (19)
- Synthesis of Acyclic Nucleotide Analogues Derived from 6-Hetarylpurines via Cross-Coupling Reactions of 9-[2-(Diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with Hetaryl Organometallic Reagents (1997) (19)
- Synthesis of new mono- and disubstituted hydroxyalkyl and aminoalkyl derivatives of heterocyclic bases (1979) (18)
- Pd-catalyzed Suzuki–Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potential multisubstrate inhibitors of thymidine phosphorylase (2007) (18)
- New in vitro method for evaluating antiviral activity of acyclic nucleoside phosphonates against plant viruses. (2010) (18)
- Synthesis of acyclic nucleotide analogues derived from N-substituted 6-(1-aminoethyl)purines via 6-acetylpurine derivatives (1997) (18)
- Synthesis and Cytostatic Activity of N‐[2‐(Phosphonomethoxy)alkyl] Derivatives of N6‐Substituted Adenines, 2,6‐Diaminopurines and Related Compounds. (2002) (18)
- Involvement of adenosine A1 receptors in upregulation of nitric oxide by acyclic nucleotide analogues. (2004) (18)
- Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine. (2006) (17)
- Prodrugs of Analogs of Nucleic Acid Components (1994) (17)
- S-adenosine-L-homocysteine hydrolase from Nicotiana tabacum L.: Isolation and properties (1984) (17)
- Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines. (1983) (17)
- Intramolecular π-π stacking interactions in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) (2009) (17)
- Synthetic reactions of dimethylformamide. XX. Preparation of some vinylogous polymethinium systems (1965) (17)
- Norbornane as the novel pseudoglycone moiety in nucleosides (2009) (17)
- Macrophage activation by antiviral acyclic nucleoside phosphonates in dependence on priming immune stimuli. (2000) (17)
- SYNTHESIS OF SOME 2'-C-ALKYL DERIVATIVES OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS (1994) (17)
- Nucleic acid components and their analogues. CLVIII. Preparation of some substituted 2-amino- and 2-mercaptopyrimidines from trimethinium salts (1973) (17)
- Nucleic acid components and their analogues. CLV. Mechanism of anomalous opening of the O 2,2' -anhydro bond in uracil cyclonucleosides (1973) (16)
- Simple Transformation of Thymine 1-[3-Hydroxy-2-(phosphonomethoxy)propyl] Derivatives to Their 1-[3-Fluoro-2-(phosphonomethoxy)propyl] Counterparts (2005) (16)
- Charge density study of hydrogen [(2,4-diaminopyrimidin-1-io)methyl]phosphonate monohydrate. (2002) (16)
- Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells. (2007) (16)
- Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy. (2008) (16)
- Synthesis of 5'-O-phosphonomethyl derivatives of pyrimidine 2'-deoxynucleosides (1990) (16)
- S-(Pyrimidin-2-yl)-L-cysteine: Chemical synthesis and biosynthesis in Escherichia coli (1974) (16)
- Proton magnetic resonance studies of 2′-deoxynucleosides and nucleotides in the syn conformation (1978) (16)
- Preparation and synthetic utilization of 3-(adenin-9-yl)-2-hydroxyalkanoic acids and their derivatives (1984) (16)
- Synthetic reactions of dimethylformamide. XXI. The formation of aromatic compounds during the formylation reactions (1965) (16)
- Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines (2007) (16)
- The mechanism of inhibition of DNA synthesis in Escherichia coli by pyrimidin-2-one beta-D-ribofuranoside. (1973) (16)
- Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. (2006) (16)
- Metal ion-binding properties of 9-[(2-phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antiviral nucleotide analogue 9-[(2-phosphonomethoxy)ethyl]adenine (PMEA). Steric guiding of metal ion-coordination by the purine-amino group. (2010) (16)
- An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine (2004) (15)
- 9‐(S)‐(2,3‐Dihydroxypropyl)adenine inhibits the transformation of chick embryo fibroblasts infected with rous sarcoma virus (1979) (15)
- Synthesis of isomeric N-(3-fluoro-2-hydroxypropyl) and N-(2-fluoro-3-hydroxypropyl) derivatives of purine and pyrimidine bases (1992) (15)
- Synthesis and biological effects of N-(2-phosphonomethoxyethyl) derivatives of deazapurine bases (1993) (15)
- Effect of 9-(S)-(2,3-dihydroxypropyl)adenine on experimental rabies infection in laboratory mice. (1980) (15)
- Synthesis of Novel Racemic Conformationally Locked Carbocyclic Nucleosides Derived from 7-Substituted Bicyclo[2.2.1]hept-5-ene-2,2-dimethanols (2006) (15)
- Preparation of analogues of cytosine and 2-pyrimidinone nucleosides and their effect on bacterial ( Escherichia coli A 19) cytidine aminohydrolase (1985) (15)
- A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity (2013) (15)
- Immunomodulatory properties of antiviral acyclic nucleotide analogues: cytokine stimulatory and nitric oxide costimulatory effects. (1997) (15)
- Antiviral activity of selected nucleoside analogues against human herpes virus type 6 (1995) (15)
- [5-(Adenin-9-yl)-5-deoxy-L-pentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. II. Synthesis of L-ribo and L-xylo Configurated Derivatives by Recyclization of Diethyl (5-RS)-[1,2-O-Isopropylidene-5-O-methanesulfonyl-D-pentofuranos-5-C-yl]phosphonates under Acidic Condi (1993) (15)
- Arrest of Trypanosoma brucei rhodesiense and T. brucei brucei in the S-phase of the cell cycle by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA). (1998) (15)
- Synthesis of 2'-deoxythymidine, 2'-deoxy-5-fluorouridine, and 2'-deoxy-6-azauridine from ribonucleosides (1974) (15)
- Synthesis of Racemic 9-(6- and 2,6-Substituted 9H-Purin-9-yl)-5-oxatricyclo[4.2.1.03,7]nonane-3-methanols, Novel Conformationally Locked Carbocyclic Nucleosides (2005) (15)
- TRANSPORT OF ADEFOVIR (PMEA) IN HUMAN T-LYMPHOBLASTOID CELLS (1997) (15)
- Phosphorylation of Purine (Phosphonomethoxy)alkyl Derivatives by Mitochondrial AMP Kinase (AK2 Type) from L1210 Cells. (2001) (14)
- Metabolism of 9-(S)-(2,3-dihydroxypropyl)adenine, an antiviral agent, in mice. (1981) (14)
- Inhibitory effect of a broad-spectrum antiviral agent, (S)-9-(2,3-dihydroxypropyl)adenine, on spermatogenesis in mice. (1981) (14)
- Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. (2008) (14)
- Interactions of calf spleen purine nucleoside phosphorylase with antiviral acyclic nucleoside phosphonate inhibitors: kinetics and emission studies. (1999) (14)
- Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages. (2005) (14)
- Stability and structure of binary and ternary metal ion complexes in aqueous solution of the quaternary 1-[2-(phosphonomethoxy)ethyl] derivative of 2,4-diaminopyrimidine (PMEDAPy-). Properties of an acyclic nucleotide analogue (2003) (14)
- The effect of polymers and trinucleoside diphosphates containing 8-azaguanine upon the binding of [14C]valine-sRNA to ribosomes. (1966) (14)
- Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine. (2004) (14)
- Solvent-dependent metal ion-adenine recognition. Quantification of the intramolecular equilibria between various isomers of the copper(2+) complexes formed in water-dioxane mixtures with the anions of the antiviral 9-(2-(phosphonomethoxy)ethyl)adenine (PMEA), an adenosine monophosphate (AMP) analog (1993) (14)
- Reaction of sugar 2-amino[1',2':4,5]oxazolines with substituted alkyl β-halo- and β-alkoxyacrylates (1974) (13)
- Structure—Antiviral Activity Relationship in the Series of Pyrimidine and Purine N-[2-(2-Phosphonomethoxy)ethyl] Nucleotide Analogues. Part 1. Derivatives Substituted at the Carbon Atoms of the Base. (1999) (13)
- Synthesis of phosphonylmethyl analogues of diribonucleoside monophosphates containing modified internucleotide bond (1987) (13)
- Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7 H -purine-8(9 H )-thione and 8-(Methylsulfanyl)adenine (2000) (13)
- Synthesis and biological evaluation of acyclic nucleotide analogues with a furo(2,3-d)pyrimidin- 2(3H)-one base (2010) (13)
- Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir). (1999) (13)
- Bifunctional Acyclic Nucleoside Phosphonates. 1. Symmetrical 1,3-Bis[(phosphonomethoxy)propan-2-yl] Derivatives of Purines and Pyrimidines (2006) (13)
- Metal-ion binding properties of O-phosphonatomethylcholine (PMCh-). Effect of the positive charge of a distant trimethylammonium group on the coordinating qualities of a phosph(on)ate group (2002) (13)
- Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2'-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9. (2001) (13)
- Synthesis and Biological Effects of Acyclic Analogs of Deazapurine Nucleosides (1993) (13)
- Synthesis of racemic and optically active erythro - and threo -9-(2,3,4-trihydroxybutyl)adenines and related compounds (1979) (13)
- Preparation, antibacterial effects and enzymatic degradation of 5-fluorouracil nucleosides (1980) (13)
- Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. (1996) (13)
- Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity. (2006) (12)
- Nucleic acid components and their analogues. CLVI. Preparation of enantiometric 1-(α-xylofuranosyl), 1-(α-lyxofuranosyl), and 1-(2-deoxy-α-lyxofuranosyl) derivatives of uracil and cytosine (1973) (12)
- Transformation of nucleosides into their 5′-deoxy derivatives (1972) (12)
- Anticancer effect of PMEDAP--monitoring of apoptosis. (2000) (12)
- Inhibition of nucleoside-binding sites by nucleoside analogues in Escherichia coli. (1974) (12)
- Substrate specificity of bacterial thymidylate-synthetase (1974) (12)
- Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents (2010) (12)
- Synthesis of 1-(3-azido-2,3-dideoxy-β-d-allofuranosyl)thymine, 1-(2,3-dideoxy-β-d-allofuranosyl)thymine, and 1-(2,3-dideoxy-β-d-erythro-hex-2-enofuranosyl)thymine (1992) (12)
- A synthesis of 2'-deoxy-L-uridine. (1971) (12)
- Oligonucleotidic compounds. XI. Synthesis of ribonucleoside-2',3' cyclophosphates from nucleosides via nucleoside 2',3'-phosphites (1966) (12)
- Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2‐(Purin‐9‐yl)ethoxyphenylphosphonic Acids (2010) (12)
- Synthesis of Novel Carbocyclic Nucleoside Analogues Derived from 2-(Hydroxymethyl)bicyclo[2.2.1]heptane (2007) (12)
- Syntheses of Enantiomeric N‐(3‐Hydroxy‐2‐phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases. (1993) (12)
- Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir. (2005) (12)
- Preparation of enantiomeric and racemic 2,3,4,5-tetrahydroxypentyl derivatives of adenine, cytosine and uracil (1982) (12)
- 6-Guanidinopurine nucleosides and their analogues (2002) (12)
- Recognition of synonym codons by purified yeast tRNA-val fractions and fragments from tRNA1-val. (1967) (12)
- Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 3-(Hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol (2006) (12)
- Oligonucleotidic compounds. XXIX. Reactions of ribonucleoside 2'(3')-phosphates with dimethylformamide acetals (1969) (12)
- Antiviral acyclic nucleoside phosphonate analogues as inhibitors of purine nucleoside phosphorylase. (1998) (12)
- Synthesis of 4- and 5-amino-1-(2-deoxy-D-erythro-pentofuranosyl)imidazole nucleosides by chemical and biotransformation methods. (1992) (11)
- Synthesis of novel carbocyclic nucleoside analogues derived from 7-oxabicyclo[2.2.1]heptane-2-methanol (2009) (11)
- [5-(Adenin-9-yl)-5-deoxypentofuranosyl]phosphonates - A Novel Type of Nucleotide Analogs Related to HPMPA. I. Derivatives with L- arabino , D- arabino , 2-Deoxy-L- erythro and 2-Deoxy-L- threo Configuration (1993) (11)
- Synthesis of Purine Nucleoside Analogues Derived from Carbocyclic 5- C -(Hydroxymethyl)hexopyranoses (2004) (11)
- Phosphonylmethyl analogues of ribonucleoside 2',3'-cyclic phosphates and 2'(3')-nucleotide methyl esters: Synthesis and properties (1985) (11)
- Pretreatment of the host cell with 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is sufficient for its antiviral effect. (1992) (11)
- Catalytic hydrogenation causes C-benzyl bond cleavage in 6-amino-7,7-dibenzyl-2,4-dimethoxy-7H-pyrrolo[3,2-d]pyrimidine: an example indicating novel route to 6-amino-7-benzyl-5H-pyrrolo-[3,2-d]pyrimidines and related compounds (1998) (11)
- Synthesis and Biological Effects of 9-(3-Hydroxy-2-phosphonomethoxypropyl) Derivatives of Deazapurine Bases (1993) (11)
- Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages. (2012) (11)
- Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) (2004) (11)
- Magnesium complexes of the antiviral 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) and of its 1-, 3-, and 7-deaza analogues in aqueous solution (1998) (11)
- Synthesis of N-(2,3-dihydroxypropyl) derivatives of heterocyclic bases (1978) (11)
- Enhanced Topical and Transdermal Delivery of Antineoplastic and Antiviral Acyclic Nucleoside Phosphonate cPr-PMEDAP (2011) (11)
- Synthesis of 1-(3-Azido-2,3-dideoxy-4- C -hydroxymethyl-α-L- threo -pentofuranosyl)thymine, 1-(2,3-Dideoxy-4- C -hydroxymethyl-α-L- glycero -pentofuranosyl)thymine and 1-(2,3-Dideoxy-4- C -hydroxymethyl-α-L- glycero -pent-2-enofuranosyl)thymine (1993) (11)
- ANTIVIRAL ACTIVITY OF ALIPHATIC NUCLEOSIDE ANALOGS: STRUCTURE-FUNCTION RELATIONSHIP (1979) (11)
- Extent of Intramolecular π‐Stacks in Aqueous Solution in Mixed‐Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and Several 2‐Aminopurine Derivatives of the Antivirally Active Nucleotide Analog 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA) (2012) (11)
- Ternary Copper(II) Complexes in Solution[1,2] Formed With 8-Aza Derivatives of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)Ethyl]Adenine (PMEA) (2000) (11)
- An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives (1999) (11)
- Synthesis of 3-amino- and 3-azidoanalogs of 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) (1989) (11)
- Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA). (1993) (11)
- Synthesis of 8-Amino- and N-Substituted 8-Aminoadenine Derivatives of Acyclic Nucleoside and Nucleotide Analogs (2001) (11)
- Synthesis of Novel Carbocyclic Nucleosides and Pro-Tides Derived from 4-Oxatricyclo[4.2.1.03,7]nonane-9-methanol (2007) (11)
- 2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells. (1990) (11)
- Inhibition of murine lymphocyte proliferation by N 6 -substituted acyclic purine nucleoside phosphonates (1996) (11)
- Synthesis of N-(2-(2-phosphonylethoxy)ethyl) derivatives of heterocyclic bases (1990) (11)
- Nucleic acid components and their analogues. IC. Synthesis of 6-azauridine 5'-methanephosphonate and 6-azauridine (2')3'-methanephosphonate (1967) (11)
- The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind–Srogl cross-coupling reaction (2011) (11)
- Enzymatic Polymerization of Phosphonate Nucleosides (2008) (11)
- Synthesis of Quaternary 1-[2-(Phosphonomethoxy)ethyl] Derivatives of 2,4-Diaminopyrimidine and Related Acyclic Nucleotide Analogs (1999) (11)
- Antiviral potential of “new” acyclic nucleoside phosphonates, the 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines (2004) (11)
- Intramolecular Cyclization of Some Acyclic Nucleoside Analogs (1996) (10)
- Preparation of 9-(β-D-ribofuranosyl)-2-hydroxypurine (1979) (10)
- [Methylation of dinucleoside phosphates with diazomethane]. (1966) (10)
- Conformational Studies on Diribonucleoside Monophosphate Analogs Containing a Nonisosteric, Isopolar, Phosphonate-Based Internucleotide Linkage (1997) (10)
- The substrate specificity of bovine seminal vesicle fluid ribonuclease (ribonuclease AS). (1972) (10)
- Synthesis and coding properties of 8-azaguanosinecontaining triribonucleoside diphosphates. (1968) (10)
- Mechanism of the Isotopic Exchange Reaction of the 5‐H Hydrogen of Uracil Derivatives in Water and Nonprotic Solvents (2011) (10)
- Preparation of 2'(3')-O-phosphonylmethyl derivatives of ribonucleosides (1983) (10)
- Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9. (2001) (10)
- A simple synthesis of 5-fluoro-2-pyrimidinone and its N 1 -substituted derivatives (1977) (10)
- Stereospecific synthesis of isomeric 4-substituted 9-(2,3-dihydroxybutyl)adenines (1982) (10)
- Synthesis of Enantiomeric N-(2-Phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases. Part 1. The Stepwise Approach. (1996) (10)
- 9-(Aminoalkyl)-8-hydroxyadenines: Preparation, mechanism of formation and use in affinity chromatography of S-adenosyl-L-homocysteine hydrolase (1986) (10)
- Synthesis of phosphonomethoxyethyl or 1,3-bis(phosphonomethoxy)propan-2-yl lipophilic esters of acyclic nucleoside phosphonates (2007) (10)
- Synthesis of eight stereoisomeric 5-(adenin-9-yl)-2,3,4-trihydroxypentanoic acids (1982) (10)
- Synthesis and structure–activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production (2015) (10)
- Acyclic Nucleoside and Nucleotide Analogs Derived from 2-Azaadenine (1995) (10)
- Nickel(II), Copper(II) and Zinc(II) Complexes of 9-[2- (Phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-Aza Derivative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl] adenine (PMEA). Quantification of Four Isomeric Species in Aqueous Solution (2004) (9)
- Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine. (2007) (9)
- Genotoxicity of purine acyclic nucleotide analogs. (1997) (9)
- Reductive cyclization of 6-cyanomethyl-5-nitropyrimidines - an efficient route to 7-alkyl-5H-pyrrolo[3,2-d]pyrimidines and 6-amino-7,7-dialkyl-7H-pyrrolo[3,2-d]primidines. Utilization in the synthesis of 9-deaza analogues of DHPA. (1997) (9)
- The coding properties of some triribonucleoside diphosphates containing inosine (1967) (9)
- DNA-Polymerases α, δ and ε from T-Cell Spontaneous Lymphoblastic Leukemia of Sprague-Dawley Inbred Rat: Isolation and Characterization (1995) (9)
- Nucleic acid components and their analogues. CXXX. Preparation of nucleotide derivatives of 1'-homouridine and their behaviour towards some nucleolytic enzymes (1970) (9)
- Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl) adenine and 6-azauridine. (1980) (9)
- Distribution and metabolic transformation of 9-( S )-(2,3-dihydroxypropyl)adenine, an effective virostatic agent, in mice (1978) (9)
- Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells. (2010) (9)
- Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3. (2007) (9)
- Modulation of cell cycle progression and of antibody production in mouse hybridomas by a nucleotide analogue (1998) (9)
- Synthesis and Biological Activity of Isopolar Acyclic Nucleotide Analogs (2002) (9)
- The coding properties of polymers and trinucleoside diphosphates containing 8-azaguanosine (1967) (9)
- Interactions of Trimeric Purine Nucleoside Phosphorylases with Ground State Analogues—Calorimetric and Fluorimetric Studies (2003) (9)
- Synthesis of Carba Analogues of 2'-Deoxy-4'- C -(hydroxymethyl)nucleosides (1999) (9)
- Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: in vitro study on MDBK cell and BHV-1 virus. (2012) (9)
- Nucleic acid components and their analogues CXXIX. Synthesis of enantiomeric 2',3'-cyclic phosphates of 9-(α-lyxofuranosyl)adenine and -hypoxanthine and their behaviour towards ribonuclease T 1 and T 2 (1969) (9)
- Synthesis of 5'-deoxyuridine 5'-phosphonic acid. (1967) (9)
- Investigation of the acid-base and electromigration properties of 5-azacytosine derivatives using capillary electrophoresis and density functional theory calculations. (2017) (9)
- Oligonucleotidic compounds. XV. A general approach to the stepwise synthesis of ribooligonucleotides. Synthesis of some triribonucleoside diphosphates (1966) (9)
- Synthesis of N9- and N7-[2-hydroxy-3-(phosphonomethoxy)-propyl] derivatives of N6-substituted adenines, 2,6-diaminopurines and related compounds (2004) (8)
- Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines (2005) (8)
- Preparation of C-5 Substituted Cidofovir Derivatives (2006) (8)
- Synthesis of Carba Analogues of Deoxy-4- C -(hydroxymethyl)pentofuranoses, Intermediates in the Synthesis of Carbocyclic Nucleosides (1998) (8)
- Preparation of acyl derivatives of pyrimidin-2-one nucleosides by the silyl variant of the Hilbert-Johnson reaction (1977) (8)
- Synthesis of Acyclic Nucleoside Phosphonates (2005) (8)
- Isotopic Exchange of Hydrogen at C‐5 in Pyrimidine Derivatives: Tautomers with an sp3‐Hybridised C‐5 Carbon Atom (2009) (8)
- Nucleic acid components and their analogues. CXXXVII. Preparation and properties of some N-(2-hydroxyethyl) derivatives of ribonucleosides and nucleotides (1971) (8)
- Synthesis of 3'-azido-2',3'-dideoxy-6-methyluridine, 2',3'-dideoxy-6-methyluridine and 2',3'-dideoxy-2',3'-didehydro-6-methyluridine (1990) (8)
- Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity (2011) (8)
- Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase. (2008) (8)
- The inhibition of peptidyl transferase activity by aminoacyl derivatives of some nucleoside aliphatic analogues. (1974) (8)
- 5'-O-Alkyl-5-fluorouridines: synthesis and biological activity (1987) (8)
- Bifunctional Acyclic Nucleoside Phosphonates: 2. Symmetrical 2-{[Bis(phosphono)methoxy]methyl}ethyl Derivatives of Purines and Pyrimidines (2007) (8)
- An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli. (2012) (8)
- Synthesis of Deoxy, Dideoxy and Didehydrodideoxy Analogs of 9-(β-D-Hexofuranosyl)adenine (1994) (8)
- A facile synthesis of 9-deaza analogue of olomoucine (2003) (8)
- Acyclic Nucleotide Analogues and Related Compounds (1995) (8)
- A synthesis of 6-methyl-2′-deoxyuridine (1973) (8)
- Fluorination of 6-methyluracil and its nlcleosides. (1977) (8)
- Transport of nucleosides in Bacillus subtilis: the effect of purine nucleosides on the cytidine-uptake. (1974) (8)
- Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats. (1993) (8)
- Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates. (2007) (8)
- Oligonucleotidic compounds. XXIV. Synthesis of 2',3'-cyclic phosphates of inosine, xanthosine, 9-(β-D-ribofuranosyl)-6-mercaptopurine, and 9-(β-D-ribofuranosyl)-2-amino-6-mercaptopurine (1968) (8)
- Synthesis of Novel Carbocyclic Nucleoside Analogues Containing Bicyclo[2.2.1]hept-2-ene-2-methanol (2008) (8)
- Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas. (1993) (8)
- 6-Azauridine-5'-uronic acid and related compounds: Synthesis and binding to proteins (1974) (8)
- Changes in coding properties of poly- and oligonucleotides containing 6-azapyrimidine ribonucleosides (1968) (8)
- Synthesis of 2'(3')-phosphates and 2'(3')-phosphorothioates of 5'-O-carboxymethylinosine and related compounds (1980) (8)
- Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants. (2011) (8)
- Preparation of isomeric 3-aminopropylamino derivatives of 9-( RS )-(2,3-dihydroxypropyl)adenine (1983) (8)
- Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs. (1995) (8)
- Effect of 5'-substitution on the template activity of oligo-nucleotides for the binding of valine and alanine tRNA to ribosomes. (1970) (8)
- General Method of Preparation of N -[( S )-(3-Hydroxy-2-phosphonomethoxypropyl)] Derivatives of Heterocyclic Bases (1993) (8)
- Oligonucleotidic compounds. XXX. Synthesis of some 5'-O-substituted derivatives of guanosine 2',3'-cyclic phosphate and guanylyl-(3'→5')-uridine (1969) (8)
- Preparation of aliphatic analogues of S-adenosyl-L-homocysteine and related compounds (1981) (7)
- Acyclic nucleoside and nucleotide analogues: a new class of antivirals. (1991) (7)
- Synthesis of Analogues of Acyclic Nucleoside Diphosphates Containing a (Phosphonomethyl)phosphanyl Moiety and Studies of Their Phosphorylation (2009) (7)
- Ribonucleosides of 3-amino- and 3,5-diaminopyrazole-4-carboxylic acid and their open-chain analogues: Synthesis and reactions (1986) (7)
- Interaction of Phosphates of the Acyclic Nucleoside Phosphonates with Nucleoside Diphosphate Kinase from Yeast and Bovine Liver (2006) (7)
- Utilization of 1,6-anhydrohexoses for the preparation of some aliphatic adenosine analogs (1989) (7)
- Nonproteolyzed Form of DNA-Polymerase ε from T-Cell Spontaneous Lymphoma of Sprague-Dawley Inbred Rat: Isolation and Characterization (1998) (7)
- Preparation of orotidine, 2'-deoxyorotidine, and related compounds (1975) (7)
- C-Functionalization of 9-deazapurines by cross-coupling reactions (2007) (7)
- Synthesis of Base Substituted 2-Hydroxy-3-(purin-9-yl)-propanoic Acids and 4-(Purin-9-yl)-3-butenoic Acids (2003) (7)
- "Abbreviated" NAD + Analogues Containinga Phosphonate Function (1996) (7)
- The Substrate Activity of (S)-9-[3-Hydroxy-(2-phosphonomethoxy)Propyl]Adenine Diphosphate toward DNA Polymerases α, δ and ε (2004) (7)
- Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening. (2012) (7)
- Nucleic acid components and their analogues. CLXII. Preparation of 6-methyl-2'-deoxyuridine and related compounds (1973) (7)
- Effect of 5'-terminal phosphate on the recognition of some dinucleoside phosphates by [14C]aminoacyl-tRNA. (1968) (7)
- Synthesis of novel racemic carbocyclic nucleoside analogues derived from 4,8-dioxatricyclo[4.2.1.03,7]nonane-9-methanol and 4-oxatricyclo[4.3.1.03,7]decane-10-methanol, compounds with activity against Coxsackie viruses (2009) (7)
- Preparation of 2-pyrimidinone and derivatives (1975) (7)
- Characteristics of the antiviral effect of 9-(S)-(2, 3-dihydroxypropyl)adenine. (1980) (7)
- Synthese von 5-Methyl-uridylyl-(3′-5′)-uridin, Uridylyl-(3′-5′)-inosin, Uridylyl-(3′-5′)-1-methyl-inosin und Uridylyl-(3′-5′)-6-methoxy-9-[β-D-ribofuranosyl]-purin (1966) (7)
- New synthesis of ribonucleoside carbocyclic analogues (1976) (7)
- Acyclic nucleoside and nucleotide analogues derived from 1-deaza and 3-deazaadenine (1990) (7)
- Nucleic acids components and their analogues. LXXX. Preparation of nucleoside phosphites by reacion of nucleosides with triphenyl phosphite (1966) (7)
- PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions. (2003) (7)
- Metabolism of cytokinins in rape seedlings ( Brassica napus L.) (1977) (6)
- The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions (2011) (6)
- Facilitation of the copper(II)-promoted dephosphorylation of adenosine 5′-triphosphate (ATP4–) by the antiviral nucleotide analogue, 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)‡ (1998) (6)
- Inhibitory effects of 9-(2,3-dihydroxypropyl)adenine and 3-(adenin-9-yl)-2-hydroxypropanoic acid 2-methylpropylester on potato virus X replication. (1988) (6)
- Preparation of substituted (±)-5 t -hydroxymethyl-3 t -aminocyclopentane-1 r ,2 c -diol derivatives related to carbocyclic ribonucleoside analogues (1976) (6)
- O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity. (2001) (6)
- SYNTHESIS OF ACYCLIC NUCLEOTIDE ANALOGUES DERIVED FROM 2-(AMINOMETHYL)ADENINE AND 2-(AMINOMETHYL)HYPOXANTHINE (1995) (6)
- Synthesis of a GpUpU analogue containing 5'-deoxyuridine 5'-phosphonic acid and its effect upon the binding of [14C]valyl- and [14C]alanyl-tRNA to ribosomes. (1967) (6)
- Synthesis of guanidino analogues of PMPDAP and their immunobiological activity. (2008) (6)
- SYNTHESIS OF ACYCLIC NUCLEOTIDE ANALOGUES DERIVED FROM 6-(SEC- OR TERT-ALKYL)PURINES VIA COUPLING OF 6-CHLOROPURINE DERIVATIVES WITH ORGANOCUPRATES (1998) (6)
- Oligonucleotide conformations. 4. Temperature and solvent effects on different uridylyl-uridines. (1974) (6)
- Nucleic acids components and their analogues. LXXXI. A selective synthesis of ribonucleoside-2'(3') phosphites (1966) (6)
- Effect of substitution of halogen or N 3 -methyl derivatives of uridine for uridine in trinucleotide codons on their recognition by aminoacyl-[ 14 C]-tRNA (1968) (6)
- SYNTHESIS OF SOME ABBREVIATED NAD+ ANALOGUES (1997) (6)
- STUDIES ON S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. PART V. SYNTHESIS AND ANTIVIRAL ACTIVITY OF STEREOISOMERIC ERITADENINES (1982) (6)
- Different anticodons in purified valine tRNA fractions from yeast. (1968) (6)
- Inducible and constitutive nucleoside-binding sites in Escherichia coli: differential inhibition by nucleoside analogues. (1974) (6)
- Interactions of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) Diphosphate with DNA Polymerases α, δ and ε* (2001) (6)
- Synthesis of Some N4-Substituted Derivatives of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) (2005) (6)
- Synthesis of ribonucleoside 5'-O-hydroxymethanephosphonates (1971) (6)
- n‐π* Transitions in azapyrimidine nucleosides (1970) (6)
- Oligonucleotidic compounds. XXXVIII. Synthesis of diribonucleoside phosphates and triribonucleoside diphosphates derived from adenosine 3'-phosphate and guanosine 3'-phosphate: A general approach to the synthesis of oligonucleotides (1970) (6)
- Modulator of intracellular Ca(2+), thapsigargin, interferes with in vitro secretion of cytokines and nitric oxide. (2005) (6)
- Tricyclic Purine Analogs Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts (2006) (6)
- Extent of intramolecular π stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the anticancer and antivirally active 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG). A comparison with related acyclic nucleotide analogues ☆ (2016) (6)
- Preparation of 9-(2-phosphonomethoxyethyl)adenine esters as potential prodrugs (1994) (6)
- Preparation of 6-methyluridine, 6-ethyluridine, and 2'-deoxy-6-ethyluridine (1974) (6)
- Synthesis of 9‐(2‐Phosphinomethoxyethyl)adenine and Related Compounds. (1995) (6)
- Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position (2007) (6)
- In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG. (2009) (6)
- Transformation of 8-[(2-Hydroxyalkyl)sulfanyl]adenines to 6-Amino-7H-purin-8(9H)-one Derivatives (2001) (6)
- Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats. (1993) (6)
- Nucleic acids components and their analogues. LXXI. Oxidation of nucleoside 5'-phosphites on treatment with halo acid derivatives and hexachloroacetone (1965) (6)
- 5'-O-diphosphorylphosphonylmethylribonucleosides - A new group of DNA-dependent RNA polymerase inhibitors (1983) (5)
- The preparation of substituted pentamethinium salts (1965) (5)
- Synthesis and antiviral activity of acyclic nucleoside and nucleotide derivatives of 8-azaadenine (1993) (5)
- Pd‐Catalyzed Suzuki—Miyaura Coupling Reactions in the Synthesis of 5‐Aryl‐1‐[2‐(phosphonomethoxy)ethyl]uracils as Potential Multisubstrate Inhibitors of Thymidine Phosphorylase. (2007) (5)
- New fluorinated nucleoside analogues with 2-butenolide rings prepared by nucleophilic vinylic fluorine displacement in 4,4-dialkyl-2,3-difluorobut-2-en-4-olides (2001) (5)
- New Ternary Complexes of Copper(II) with 2,2′‐Bipyridine (Bpy) and Phosphocholine (PCh–) or the Quaternary 1‐(2‐Phosphonomethoxy)ethyl Derivative of 2,4‐Diaminopyrimidine (PMEDAPy–) (2007) (5)
- On the specificity of pancreatic ribonuclease towards 2',3'-cyclic phosphates derived from alpha-lyxofuranosyl derivatives of thymine. (1968) (5)
- Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3. (2006) (5)
- Synthesis and Properties of 2-Guanidinopurines (2006) (5)
- The preparation of 3H-labeled acyclic nucleoside phosphonates and study of their stability (2010) (5)
- Nucleic acids components and their analogues. XCV. Synthesis of ribonucleoside 5'-phosphites (1967) (5)
- Synthesis of Novel Types of Anti-Coxsackie Virus Compounds (2007) (5)
- The synthesis and the pharmacological properties of enantiomeric derivatives of 7-(2,3-dihydroxypropyl)theophylline (1979) (5)
- SYNTHESIS OF 5-PHENYLCYTOSINE NUCLEOSIDE DERIVATIVES (1996) (5)
- Synthesis of Base-Modified "Abbreviated" NAD Analogues (1995) (5)
- Inhibition by CTP and UTP analogues of uridine kinase from mouse leukemic cells (1982) (5)
- Substrate specificity of some microbial guanyloribonucleases (1974) (5)
- The mutagenicity of azido derivatives of monosaccharides and alcohols and of N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines in Arabidopsis thaliana and in Salmonella typhimurium. (1991) (5)
- Inhibition of DNA synthesis in Escherichia coli by 1-(β-D-ribofuranosyl)-2-pyrimidone (1972) (5)
- Simple Transformation of Thymine 1‐[3‐Hydroxy‐2‐(phosphonomethoxy)propyl] Derivatives to Their 1‐[3‐Fluoro‐2‐(phosphonomethoxy)propyl] Counterparts. (2006) (5)
- ALKYL ESTERS OF 3-ADENIN-9-YL-2-HYDROXYPROPANOIC ACID: A NEW CLASS OF BROAD-SPECTRUM ANTIVIRAL AGENTS (1985) (5)
- An improved synthesis of S-adenosyl-L-homocysteine and related compounds (1985) (5)
- Metal-ion binding properties of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir). A nucleotide analogue with activity against DNA viruses (2017) (5)
- SYNTHESIS OF 5-PHENYL-2(1H)-PYRIMIDINONE NUCLEOSIDES (1996) (5)
- Studies on the effect of 9-(R, S)-(2,3-dihydroxypropyl)adenine on tick-borne encephalitis virus. (1982) (5)
- Acid-catalyzed migration of N 4 -acyl groups in cytosine derivatives (1979) (5)
- Nucleic acid components and their analogues. CL. Preparation and properties of some nucleoside hydroxyalkanephosphonates (1972) (5)
- Oligonucleotidic compounds. XX. A general method for the synthesis of 5'-O-phosphorylribonucleoside 2',3'-cyclic phosphates (1967) (5)
- Structural features of acyclic nucleotide analogs conferring inhibitory effects on cellular replicative DNA polymerases (1996) (5)
- Synthesis of Optically Active N6-Alkyl Derivatives of (R)-3-(Adenin-9-yl)-2-hydroxypropanoic Acid and Related Compounds (2002) (5)
- Nucleic acid components and their analogues. CXLVII. Preparation of 5-ethoxycarbonyluridine, 5-carboxyuridine and their nucleotidic derivatives (1972) (5)
- Efficient synthesis of pyrimidinecarbonitriles and their derivatives (2007) (5)
- Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG. (2011) (5)
- In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450. (2008) (5)
- 2',3'-Dideoxy- and 3'-Azido-2',3'-dideoxynucleosides of 5-Phenyl-2(1H)-pyrimidinone. Preparation of 2',3'-Dideoxypentofuranoses (1996) (5)
- Preparation of 5-Benzyluracil and 5-Benzylcytosine Nucleosides as Potential Inhibitors of Uridine Phosphorylase (1996) (5)
- Synthesis of 2′‐Aminomethyl Derivatives of N‐(2‐(Phosphonomethoxy) ethyl) Nucleotide Analogues as Potential Antiviral Agents. (1996) (5)
- Synthesis of novel racemic carbocyclic nucleosides derived from 5,6-disubstituted norbornene (2010) (5)
- CD studies on the conformation of oligonucleotides complexed with divalent metal ions: interaction of Zn2+ with guanine favours syn conformation. (1976) (5)
- Oligonucleotidic compounds. XXXII. Phosphorylation of 1-lyxofuranosyl, 1-xylofuranosyl and 1-arabinofuranosyl derivatives of uracil and thymine with triethyl phosphite and hexachloroacetone (1969) (5)
- DNA-dependent RNA polymerase mediated formation of methylphosphonyl internucleotide linkage (1990) (5)
- Synthesis of 1-(3-Azido-2,3-dideoxy-β-D- ribo -hexofuranosyl)-, 1-(2,3-Dideoxy-β-D- erythro -hexofuranosyl)- and 1-(2,3-Dideoxy-β-D- erythro -hex-2-enofuranosyl)pyrimidine Nucleosides (1994) (5)
- Antiviral activity of 2-phosphonomethoxyalkyl derivatives of N6-substituted 6-aminopurines (1995) (5)
- Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine. (1997) (5)
- Nucleic acids components and their analogues. LIX. The preparation and properties of nucleoside phosphites (1965) (5)
- Synthesis of Carbocyclic 4'- C -Hydroxymethyl Analogues of Azidodeoxythymidine, Deoxythymidine, Deoxydidehydrothymidine and Thymidine Carba Analogue with Fused Oxetane Ring (2000) (5)
- Ribonucleoside 5′‐aminomethanephosphonates: Synthesis and affinity towards some phosphomonoesterases (1972) (4)
- Nucleic acid components and their analogues. CXLVI. Preparation of some nucleotide derivatives of 6-methyluridine, 3-(β-D-ribofuranosyl)uracil, and 3-(β-D-ribofuranosyl)-6-methyluracil. Investigations of their template activity and behaviour towards some nucleolytic enzymes (1972) (4)
- Coupling of 6‐Chloropurines with Organocuprates Derived from Grignard Reagents: A Convenient Route to sec and tert 6‐Alkylpurines. (1996) (4)
- Stereospecific synthesis of β-D-ribopyranosyl nucleoside analogues (1975) (4)
- Synthesis of deoxy, dideoxy and didehydrodideoxy analogs of 9-(4-C-hydroxymethyl-α-L-pentofuranosyl)adenine (1994) (4)
- Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates. (1999) (4)
- Nucleic acid components and their analogues. CXXXVIII. Synthesis of 2',3'-cyclic phosphates derived from some pyrimidine ribonucleosides and their behaviour towards pancreatic ribonuclease and ribonuclease T2 (1971) (4)
- Antiviral activity of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP and ribavirin against Cauliflower mosaic virus in Brassica pekinensis (2012) (4)
- Synthetic purine nucleoside analogues (1985) (4)
- Facile preparation of purine and pyrimidine 2-deoxy-beta-D-ribonucleosides by biotransformation on encapsulated cells. (1987) (4)
- Antiinflammatory effects of phosphonomethoxyethyl analogues of adenine in a model of adjuvant arthritis. (1999) (4)
- Preparation of Thymidine-4'- C -carboxylic Acid and Its Derivatives (1997) (4)
- A Facile Synthesis of Azetidin-2-ylphosphonic Acid and Its 1-Alkyl Derivatives (2001) (4)
- Inhibition of ovarian sah-hydrolase in Pyrrhocoris apterus, sterilized with (S)-9-(2,3-dihydroxypropyl)adenine (1985) (4)
- Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma. (2001) (4)
- L‐ribonucleosides do not penetrate bacterial cell walls (1971) (4)
- Trinucleotide AUA and UAU formation catalyzed by wheat germ RNA polymerase II (1989) (4)
- Prevention of acute graft-versus-host disease in rats using 9-(2-phosphonomethoxyethyl) adenine (PMEA). (1993) (4)
- Cytostatic 6-Arylpurine Nucleosides. Part 3. Synthesis and Structure—Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl-, and 6-Benzylpurine Ribonucleosides. (2001) (4)
- Intramolecular π-stacks in mixed-ligand copper(II) complexes formed by heteroaromatic amines and antivirally active acyclic nucleotide analogs carrying a hydroxy-2-(phosphonomethoxy)propyl residue‡ (2018) (4)
- Substrate specificity of spleen acid exonuclease and spleen cyclic phosphodiesterase (1974) (4)
- Metal Ion-Coordinating Properties in Aqueous Solutions of the Antivirally Active Nucleotide Analogue (S )-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) - Quantification of Complex Isomeric Equilibria (2019) (4)
- Alternative synthesis of 9-{3-[(diisopropoxyphosphoryl)methoxy]-2-hydroxypropyl}adenine and its free phosphonates substituted at the C-8 position of purine base (2010) (4)
- The effect of some triribonucleoside diphosphates containing inosine on the binding of [14C]aminoacyl-tRNA to ribosomes. (1967) (4)
- Oligonucleotidic compounds. XVII. Synthesis of oligonucleotides containing 6-azauridine and 6-azacytidine (1967) (4)
- Isoenzymes of GMP Kinase from L1210 Cells: Isolation and Characterization (1999) (4)
- Oligonucleotide conformations 2. Optical studies on 8‐bromoguanylyl‐3′, 5′‐8‐bromoguanosine (1972) (4)
- Properties of the Ternary (Dien)Pt(PMEA-N7) Complex Containing Diethylenetriamine (Dien) and the Antiviral 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA). Synthesis, Biological Screening, Acid-Base Behaviour, and Metal Ion-Binding in Aqueous Solution (2000) (4)
- Fluorescent analogues of acyclic inhibitors of S-adenosyl-L-homocysteine hydrolase (1988) (4)
- Immunomodulatory properties of 9-(2-phosphonomethoxyethyl)-adenine (PMEA). (1994) (4)
- Preparation and biological effects of N-tris(hydroxymethyl)methylaminocarbonylmethyl derivatives of heterocyclic bases (1984) (4)
- Phosphorylation of nucleosides with trichloromethanephosphonic acid derivatives (1972) (4)
- Determination of the antioxidative activity of substituted 5-aminopyrimidines (2012) (4)
- The stimulation of ribosomal peptidyl transferase by cytosine and its derivatives (1978) (4)
- The Optimized Microwave-Assisted Decomposition of Formamides and Its Synthetic Utility in the Amination Reactions of Purines. (2011) (4)
- Hypomethylation of CNG targets induced with dihydroxypropyladenine is rapidly reversed in the course of mitotic cell division in tobacco (2002) (3)
- Carboxymethylated uracil, 2'-deoxyuridine and their 5-fluoro, 5-bromo, and 5-iodo derivatives (1975) (3)
- Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase. (2008) (3)
- Crown and azacrown ethers with pendant adenine group (1987) (3)
- Extent of Intramolecular π Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and 1-[2-(Phosphonomethoxy)ethyl]cytosine (PMEC), a Relative of Antivirally Active Acyclic Nucleotide Analogues (Part 72)[1, 2]† (2013) (3)
- Formation of a dead code triplet through replacement of the terminal ribonucleoside in guanylyl-uridylyl-uridine and guanylyl-uridylyl-cytidine by 6-azacytidine. (1966) (3)
- New carbocyclic nucleoside analogues built on a bicyclo[2.2.2]octane-2,2-dimethanol template (2009) (3)
- Synthesis of conjugates of 5-halouracils with proteins using activated esters (1979) (3)
- Preparation of Chloro and Sulfanyl Derivatives of 1-(2-Deoxy-4-C-hydroxymethyl-α-L-threo-Pentofuranosyl)uracil (1997) (3)
- The effect of phosphonylmethyl analogs of ribonucleoside 5'-diphosphates on ( E. coli ) polynucleotide phosphorylase catalyzed reactions (1987) (3)
- Nucleic acid components and their analogues. CXLII. Preparation of 3-(β-D-ribofuranosyl)uracil 2',3'-cyclic phosphate and related compounds and their behaviour towards pancreatic ribonuclease and ribonuclease T2 (1971) (3)
- Polymeric Conjugates of 9-[2-(Phosphonomethoxy)ethyl]purine with Potential Antiviral and Cytostatic Activity (2006) (3)
- Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Nucleoside Analogues (2002) (3)
- 1-(3,5- O -Alkylidene-2-deoxy-4- C -hydroxymethyl-α-L- threo -pentofuranosyl)uracils (1997) (3)
- Synthesis of N-(3-fluoro-2-phosphonomethoxypropyl) (FPMP) Derivatives of Heterocyclic Bases. (1993) (3)
- In vivo antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its cyclic form (2007) (3)
- The effect of 9-(2,3-dihydroxypropyl) adenine (DHPA) on seedling roots ofVicia faba L. in comparison with adenine, adenosine and some cytokinins (1984) (3)
- Synthesis and biological activity of N-substituted 5-fluorouracil-1-acetamides (1983) (3)
- Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP. (2010) (3)
- Synthesis and Biological Effects of N‐(2‐Phosphonomethoxyethyl) Derivatives of Deazapurine Bases. (1993) (3)
- Donor activity of 5'-O-phosphonylmethyl analogues of ATP and GTP in the phosphorylation of uridine catalyzed by uridine kinase from mouse leukemic cells (1983) (3)
- Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates. (2012) (3)
- Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Pyrimidine C -Nucleoside Analogues (2004) (3)
- Anti‐DNA Virus Agents (2010) (3)
- Synthesis of 1-(2,3-Dideoxy-4-C-methyl-β-D- glycero -pent-2-enofuranosyl)thymine, 1-(2,3-Dideoxy-4-C-methyl-β-D- glycero -pentofuranosyl)thymine and 1-(4-C-Azidomethyl-2-deoxy-β-D- threo -pentofuranosyl)thymine (1993) (3)
- Oligonucleotidic compounds. XXVII. Synthesis of diribonucleoside phosphates containing 5-halo derivatives of uridine and 3-methyluridine (1968) (3)
- Solution Structures of Binary and Ternary Metal Ion Complexes of 9‐(5‐Phosphonopentyl)adenine (3′‐deoxa‐PEEA). A Nucleotide Analogue Related to the Antivirally Active 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA) (2003) (3)
- PREPARATION OF ANALOGS OF CYTOSINE AND 2-PYRIMIDINONE NUCLEOSIDES AND THEIR EFFECT ON BACTERIAL (ESCHERICHIA COLI A19) CYTIDINE AMINOHYDROLASE (1985) (3)
- 13C and 15N NMR chemical shift assignments of N‐1‐(2‐ azidoethyl)‐4‐R‐pyrimidin‐2‐ones by 1H,X HMQ(B)C with z‐gradient selection (1998) (3)
- Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy (2008) (3)
- Inhibition of human purine nucleoside phosphorylase by tenofovir phosphate congeners (2010) (3)
- Czech bibliometric system fosters mediocre research. (2009) (3)
- Capillary electrophoresis separation of the new anti‐AIDS agents 9‐(2‐phosphonylmethoxyethyl)adenine and 9‐(2‐phosphonylmethoxyethyl)‐2,6‐diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides (1998) (3)
- Transport of antiviral agent 9-(S)-(2,3-dihydroxypropyl) adenine to animal cells. (1983) (3)
- Inhibition of protein synthesis by pyrimidone-(2)-ribofuranoside in Escherichia coli (1973) (3)
- Nucleic acid components and their analogues. CXXVIII. Phosphorylation of some thymine 1-pentopyranosyl and 1-hexopyranosyl derivatives by the reaction with triethyl phosphite and hexachloroacetone (1969) (3)
- Two Convergent Approaches towardNovel Carbocyclic C-Nucleosides (2010) (3)
- Preparation of Purine 2'-Deoxy-5'-O-phosphonomethylnucleosides and 2'-Deoxy-3'-O-phosphonomethylnucleosides (1993) (3)
- 7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine (1999) (3)
- In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes. (2006) (3)
- Synthesis and chiroptical properties of some abbreviated NAD+ analogues (1995) (3)
- A Facile Synthesis of 2-(Aminomethyl)purines (1994) (3)
- Synthesis of N4-Substituted Derivatives of 1-[2-(Phosphonomethoxy)ethyl]cytosine and Its Diisopropyl Ester as a Model Reaction for the Synthesis of N4-Substituted Derivatives of Cidofovir (2005) (3)
- Oligonucleotidic compounds. XXXV. Reaction of diribonucleoside phosphates with dimethylformamide acetals (1969) (3)
- Synthesis of 2′,5′-O-protected ribonucleosides (1967) (3)
- New pyrimidine (uridine) specific cyclizing 2'-ribonucleotidyltransferase and nonspecific decyclizing 2',3'-phosphodiesterase (1979) (3)
- Two synthetic approaches to 9-deaza analogues of 9-(2,3-dihydroxypropyl)adenine (DHPA) (1996) (3)
- Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance. (2007) (3)
- Oligonucleotidic compounds. XXI. Synthesis of (3'→5')-diribonucleoside phosphate 2',3'-cyclic phosphates from unprotected (3'→5')-diribonucleoside phosphates (1968) (3)
- Preparation, spectral properties and biological activities of 5-bromo-6-methyl-2'-deoxyuridine and 5-iodo-6-methyl-2'-deoxyuridine (1980) (3)
- Preparation of conjugates of uridine with proteins by the imido ester condensation method (1981) (3)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CXC. PREPARATION OF 2‐PYRIMIDINONE E NUCLEOSIDES FROM URACIL NUCLEOSIDES (1977) (3)
- A Facile Synthesis of 9-Deaza Analogue of Olomoucine. (2003) (2)
- Substrate specificity of rape pollen 3'-nucleotidase ( Brassica napus ) (1976) (2)
- [Studies on the reaction mechanism of a ribonuclease II from Aspergillus oryzae (author's transl)]. (1975) (2)
- Synthesis of Acyclic Adenine 8,N-Anhydronucleosides. (2001) (2)
- C-Functionalization of 9-Deazapurines by Cross-Coupling Reactions. (2007) (2)
- Conformational study on ribonucleoside O-phosphonylmethyl derivatives by 1H NMR spectroscopy (1985) (2)
- Acyclic Nucleotide Analogues Derived from 8-Azapurines: Synthesis and Antiviral Activity. (2010) (2)
- Substrate specificity of adenosine aminohydrolase from Streptomyces aureofaciens (1978) (2)
- Preparation of 5'-O-carboxymethylcytidine and 5'-O-carboxymethyl-1-(β-D-arabinofuranosyl)cytosine (1974) (2)
- Design and synthesis of 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase (2005) (2)
- Interactions of 1‐[(S)‐3‐Hydroxy‐2‐(phosphonomethoxy)propyl]cytosine (Cidofovir) Diphosphate with DNA Polymerases α, δ and ε*. (2002) (2)
- Synthesis of Carba Analogues of 2′‐Deoxy‐4′‐C‐(hydroxymethyl)nucleosides. (2000) (2)
- Synthesis of 3-(4-Pyridinyl)-, 3-(2-Chloro-4-pyridinyl)- and 3-(2-Amino-4-pyridinyl)propoxymethanephosphonic Acid (1995) (2)
- A Facile Synthesis of 6‐Cyanopurine Bases. (1996) (2)
- The Effect of Divalent Cations and Core Polymerase in the Abortive Initiation by Escherichia Coli Dna-Dependent Rna Polymerase Using Phosphonate Dinucleotide Primers (1988) (2)
- The effect of acceptor modification upon the synthesis of dinucleoside phosphates catalyzed by non-specific ribonucleases of Penicillium claviforme (1979) (2)
- 9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*. (1999) (2)
- Ribonuclease a catalyzed preparative synthesis of dinucleoside monophosphates containing uridine analogues (1980) (2)
- Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5-phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells. (1999) (2)
- HPMPApp as a substrate toward replicative DNA polymerases α, δ and ε (1999) (2)
- Synthesis of Acyclic Nucleotide Analogues Derived from 2-Amino-6-C-Substituted Purines via Cross-Coupling Reactions of 2-Amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-halopurines with Diverse Organometallic Reagents. (2001) (2)
- The unique impact of microwave irradiaton on the chemistry of acyclic nucleoside phosphonates (2011) (2)
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- Alternative Synthesis of 9‐{3‐[(Diisopropoxyphosphoryl)methoxy]‐2‐hydroxypropyl}adenine and Its Free Phosphonates Substituted at the C‐8 Position of Purine Base. (2010) (0)
- Synthesis of C-5 substituted HPMPC (cidofovir) derivatives (2005) (0)
- Synthesis and antiviral evaluation of N9-[2-(phosphonomethoxy)ethyl] (PME) analogues derived from 8-substituted purine (2011) (0)
- New application of the Stille coupling in the synthesis of 5-substituted uracils (1996) (0)
- Synthesis of acyclic nucleotide analogues derived from 2-(aminomethyl)purine bases (1995) (0)
- PREPARATION OF DERIVATIVES OF INOSINE 5′-PHOSPHOROTHIOATE FOR USE IN AFFINITY CHROMATOGRAPHY (1981) (0)
- Synthesis and structure–activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production (2014) (0)
- AND THEIR ANALOGUES. CLXII. * PREPARATION OF 6-METHYL-2' -DEOXYURIDINE AND RELATED COMPOUNDS** (1973) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CC. PREPARATION OF 9-(β-D-RIBOFURANOSYL)-2-HYDROXYPURINE (1979) (0)
- Synthesis and antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its ester prodrugs (2007) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CXCVII. THE EFFECT OF ACCEPTOR MODIFICATION UPON THE SYNTHESIS OF DINUCLEOSIDE PHOSPHATES CATALYZED BY NON-SPECIFIC RIBONUCLEASES OF PENICILLIUM CLAVIFORME (1979) (0)
- PREPARATION, ANTIBACTERIAL EFFECTS AND ENZYMIC DEGRADATION OF 5-FLUOROURACIL NUCLEOSIDES (1981) (0)
- A simple synthesis of nucleoside phosphites. (1965) (0)
- Synthesis of acyclic 9-deazanucleosides: 9-(2,3-Dihydroxypropyl)-9-deazahypoxanthine (1999) (0)
- Therapeutic effect of heat shock on T-cell lymphoma in inbred Sprague-Dawley rat. (1999) (0)
- A novel, highly stereoselective synthetic approach for the preparation of substituted 2,5-dihydro-2,5-dihydroxyfurans (2011) (0)
- Synthesis of Base Substituted 2-Hydroxy-3-(purin-9-yl)propanoic Acids and 4-(Purin-9-yl)-3-butenoic Acids. (2004) (0)
- On the methylation of dinucleoside phosphates with diazomethane. (1966) (0)
- Synthesis and Biological Effects of Acyclic Analogues of Deazapurine Nucleosides. (2010) (0)
- An Efficient Synthesis of Cytostatic Mono and Bis‐Alkynylpyrimidine Derivatives by the Sonogashira Cross‐Coupling Reactions of 2,4‐Diamino‐6‐iodopyrimidine and 2‐Amino‐4,6‐dichloropyrimidine. (2004) (0)
- N-(3-Azido-2-hydroxypropyl) derivatives of purine and pyrimidine bases (1990) (0)
- Efficient synthesis of "open-ring, close-ring" acyclic nucleoside phosphonates (2008) (0)
- Synthesis of Optically Active N6‐Alkyl Derivatives of (R)‐3‐(Adenin‐9‐yl)‐2‐hydroxypropanoic Acid and Related Compounds. (2003) (0)
- Antiviral activity of acyclic nucleoside phosphonates with branched 2-(2-phosphonoethoxy)ethyl chain (2010) (0)
- Activity of 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines against polyomaviruses (2006) (0)
- Synthesis of 3′-Azido-2′,3′-dideoxy-6-methyluridine (VI), 2′,3′-Dideoxy-6-methyluridine (IX) and 2′,3′-Dideoxy-2′,3′-didehydro-6-methyluridine (1990) (0)
- Ribonucleosides of 3-Amino- and 3,5-Diaminopyrazole-4-carboxylic Acid and Their Open-Chain Analogues: Synthesis and Reactions. (1986) (0)
- Uridine Phosphorylase Inhibitors. Potential Chemotherapeutics (2010) (0)
- The 5'-O-phosphonomethyl analog of ATP. Studies of substrate properties in ligase-dependent reactions. (1987) (0)
- Antiviral activity of acyclic nucleoside phosphonates PMEA, (S)-HPMPC, PMEDAP and ribavirin against Cauliflower mosaic virus in Brassica pekinensis (2012) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. PART CXIV. SYNTHESIS OF N-(2,3-DIHYDROXYPROPYL) DERIVATIVES OF HETEROCYCLIC BASES (1978) (0)
- Preparation of Purine 2′‐Deoxy‐5′‐O‐phosphonomethylnucleosides and 2′‐ Deoxy‐3′‐O‐phosphonomethylnucleosides. (1993) (0)
- Properties of ribonuclease, phosphodiesterase, and decyclizing phosphodiesterase from rape ( Brassica napus L.) pollen (1976) (0)
- NUCLEIC ACID COMPONENTS AND FHEIR ANALOGUES PART 158, SYNTHETIC REACTIONS OF DIMETHYLFORMAMIDE PART 26, PREPASATION OF SOME SUBSTITUTED 2-AMINO- AND 2-MERCAPTOPYRIMIDINES FROM TRIMETHINIUM SALTS (1973) (0)
- IMMUNOSUPPRESSANT ANTIGEN CONJUGATES. XXV. SYNTHESIS OF CONJUGATES OF 1-(CARBOXYMETHYL)CYTOSINE AND 1-(5-O-CARBOXYMETHYL-β-D-ARABINOFURANOSYL)CYTOSINE WITH PROTEINS (1980) (0)
- The Efficient Synthesis of 2-Arylpyrimidine Acyclic Nucleoside Phosphonates Using Liebeskind—Srogl Cross-Coupling Reaction. (2012) (0)
- New 2‐Alkynyl Derivatives of the Acyclic Nucleoside 9‐(2,3‐Dihydroxypropyl)adenine and Their 6‐Guanidinopurine Counterparts as Potential Effectors of Adenosine Receptors. (2004) (0)
- Tricyclic Purine Analogues Derived from 2-Amino-6-chloropurine and 2,6-Diaminopurine and Their Methylated Quaternary Salts. (2006) (0)
- Acyclic Nucleotide Analogues. Part 4. Phosphonylmethoxyalkyl and Phosphonylalkyl Derivatives of Adenine. (1989) (0)
- N-fosfonilmetoxialquilicos derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions based thereon, with antiviral activity. (1987) (0)
- N 6 -methyl-AMP hydrolase activates N 6 -substituted purine ANPs (2005) (0)
- A NUCLEAR MAGNETIC RESONANCE STUDY OF NUCLEOSIDE CONFORMATION IN SOLUTION, THE EFFECT OF STRUCTURE AND CONFORMATION ON THE MAGNETIC NONEQUIVALENCE OF THE 5′-METHYLENE HYDROGENS (1974) (0)
- Novel type of bis-phosphonate congeners of acyclic nucleoside phosphonates (2005) (0)
- O-isomers derived phosphonylmethyle enantiomers of racemic vicinal diols and their method of preparing (1984) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CLXXXI. PREPARATION OF SUBSTITUTED D (.+-.)-5T-HYDROXYMETHYL-3T-AMINOCYCLOPENTANE-1R,2C-DIOL DERIVATIVES RELATED TO CARBOCYCLIC RIBONUCLEOSIDE ANALOGS (1976) (0)
- Interactions of Trimeric Purine Nucleoside Phosphorylases with Ground State Analogues — Calorimetric and Fluorimetric Studies (2004) (0)
- Preparation of Phosphonomethyl Ethers Derived from 2-Phenylethanol and Its Amino Derivatives (1995) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGUES PART 169, REACTION OF SUGAR 2-AMINO(1′,2′/4,5)OXAZOLINES WITH SUBSTITUTED ALKYL BETA-HALO- AND BETA-ALKOXYACRYLATES (1975) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CXCVI. SYNTHESIS OF RACEMIC AND OPTICALLY ACTIVE ERYTHRO- AND THREO-9-(2,3,4-TRIHYDROXYBUTYL)ADENINES AND RELATED COMPOUNDS (1979) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGUES PART 168, SYNTHESIS OF 2′-DEOXYTHYMIDINE, 2′-DEOXY-5-FLUOROURIDINE, AND 2′-DEOXY-6-AZAURIDINE FROM RIBONUCLEOSIDES (1975) (0)
- Chemical stability and intracellular metabolism of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (2007) (0)
- Use of 1,3-dioxolanes in the syntheses of α-branched alkyl and aryl N-9-[2-(phosphonomethoxy)ethyl]purines (2011) (0)
- Progress in Acyclic Nucleoside and Nucleotide Chemistry and Application (1998) (0)
- Intramolecular Cyclization of Some Acyclic Nucleoside Analogues. (1996) (0)
- Synthesis of 1-(3-azido-2,3-dideoxy-beta-D-allofuranosyl)thymine, 1-(2,3-dideoxy-beta-D-allofuranosyl)thymine, and 1-(2,3-dideoxy-beta-D-erythro-hex-2-enofuranosyl)thymine. (1991) (0)
- SYNTH. VON RIBONUCLEOSID-5′-O-HYDROXYMETHANPHOSPHONATEN (1971) (0)
- Synthesis of 8- C -substituted 2,6-diaminopurine acyclic nucleoside phosphonates by Negishi cross-coupling (2008) (0)
- Perfluoroalkylation of 6‐Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6‐(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues. (1999) (0)
- Reverse transcriptase of HIV as a target for anti-HIV chemotherapy (2002) (0)
- Antiviral Activity of (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine [(S)-HPMPA] (1987) (0)
- 5′-O-Alkyl-5-fluorouridines: Synthesis and Biological Activity. (1987) (0)
- Synthesis of Novel Conformationally Locked Carbocyclic Nucleosides Derived from 3-(Hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol. (2006) (0)
- Synthesis of acyclic nucleotide analogues derived from 6-(aminomethyl)purines and purine-6-carboxamidines (1996) (0)
- [5-(9-Adeninyl)-5'-deoxy-L-pentofuranosyl]phosphonates: Conformationally restricted nucleotide analogs related to ( S )-HPMPA (1993) (0)
- Facile syntheses of pyrimidine acyclic nucleoside phosphonates and their potential evaluation for biomedical applications (2008) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CLXXXVIII. PREPARATION OF ACYL DERIVATIVES OF 2-PYRIMIDINONE NUCLEOSIDES BY THE SILYL VARIANT OF THE HILBERT-JOHNSON REACTION (1977) (0)
- SYNTHESIS OF 2′(3′)-PHOSPHATES AND 2′(3′)-PHOSPHOROTHIOATES OF 5′-O-CARBOXYMETHYLINOSINE AND RELATED COMPOUNDS (1981) (0)
- Antirhinovirus Activity ofPurine Nucleoside Analogs (1986) (0)
- (2r)-2-(di(2-propyl)phosphonylmethoxy)-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane, its preparation and utilization (1991) (0)
- n-pi* Transitions in azapyrimidine nucleosides. (1970) (0)
- Synthesis of Carbocyclic 4′‐C‐Hydroxymethyl Analogues of Azidodeoxythymidine (XIV), Deoxythymidine (IX), Deoxydidehydrothymidine (VII) and Thymidine Carba Analogue with Fused Oxetane Ring (V). (2000) (0)
- 1‐(3,5‐O‐Alkylidene‐2‐deoxy‐4‐C‐hydroxymethyl‐α‐L‐threo‐ pentofuranosyl)uracils. (1997) (0)
- Synthesis of acyclic nucleoside diphosphate mimics (2008) (0)
- Synthesis of acyclic nucleotide analogues derived from 5-substituted 2,4-diamino-6-hydroxypyrimidines (2002) (0)
- Sonogashira Cross‐Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6‐[(Phosphonomethoxy)alkynyl]‐ and 6‐[(Phosphonomethoxy)alkyl]pyrimidines. (2005) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGUES PART 178, STEREOSPECIFIC SYNTHESIS OF BETA-D-RIBOPYRANOSYL NUCLEOSIDE ANALOGUES (1975) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGUES PART 163, AMINO ACIDS AND PEPTIDES PART 119, S-(PYRIMIDIN-2-YL)-L-CYSTEINE, CHEMICAL SYNTHESIS AND BIOSYNTHESIS IN ESCHERICHIA COLI (1974) (0)
- Acyclic Nucleoside and Nucleotide Analogues Derived from 2-Azaadenine (1995) (0)
- STUDIES ON S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. VIII. PREPARATION OF ISOMERIC C 3-AMINOPROPYLAMINO DERIVATIVES OF 9-(RS)-(2,3-DIHYDROXYPROPYL)ADENINE (1983) (0)
- Synthesis of Novel Carbocyclic Nucleoside Analogues Derived from 2‐(Hydroxymethyl)bicyclo[2.2.1]heptane. (2008) (0)
- Synthesis of Isomeric N‐(3‐Fluoro‐2‐hydroxypropyl) and N‐(2‐Fluoro‐3‐hydroxypropyl) Derivatives of Purine and Pyrimidine Bases. (1992) (0)
- [Methylation of inosine and uridylyl-(3'-5')inosine with dimethylsulfate]. (1967) (0)
- Use of Pd-Catalyzed Suzuki—Miyaura Coupling Reaction in the Rapid Synthesis of 5-Aryl-6-(phosphonomethoxy)uracils and Evaluation of Their Inhibitory Effect Towards Human Thymidine Phosphorylase. (2010) (0)
- Synthesis of 1‐(2,3‐Dideoxy‐4‐C‐methyl‐β‐D‐glycero‐pent‐2‐ enofuranosyl)thymine, 1‐(2,3‐Dideoxy‐4‐C‐methyl‐β‐D‐glycero‐ pentofuranosyl)thymine and 1‐(4‐C‐Azidomethyl‐2‐deoxy‐β‐D‐threo‐ pentofuranosyl)thymine. (1993) (0)
- Synthesis of 5‐Phenylcytosine Nucleoside Derivatives. (1996) (0)
- (5-(Adenin-9-yl)-5-deoxypentofuranosyl)phosphonates - A Novel Type of Nucleotide Analogues Related to HPMPA. Part 1. Derivatives with L- arabino, D-arabino, 2-Deoxy-L-erythro and 2-Deoxy-L-threo Configuration. (1994) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CLXXXVI. PREPARATION OF SOME 2′-DEOXY-5-FLUOROURIDINE DERIVATIVES BY A DIRECT FLUORINATION (1977) (0)
- Structure-Activity Studies in the Series of Acyclic Nucleotide Analogues (1990) (0)
- Synthesis of Carba Analogues of Deoxy-4-C-(hydroxymethyl)hexopyranoses, Intermediates in the Synthesis of Carbocyclic Nucleosides. (2010) (0)
- Synthesis of Some “Abbreviated” NAD+ Analogues. (1997) (0)
- IMMUNOSUPPRESSANT ANTIGEN COMPLEXES. XXVIII. PREPARATION OF CONJUGATES OF URIDINE WITH PROTEINS BY THE IMIDO ESTER CONDENSATION METHOD (1981) (0)
- Preparation of Thymidine‐4′‐C‐carboxylic Acid and Its Derivatives. (1997) (0)
- Cross-coupling reactions of 2,6-dichloro-9-deazapurine (2002) (0)
- Synthesis of Novel Carbocyclic Nucleosides [cf. (I)] and Pro‐Tides [cf. (II)] Derived from 4‐Oxatricyclo[4.2.1.03,7]nonane‐9‐methanol. (2008) (0)
- Synthesis of Acyclic Nucleotide Analogues Derived from N-Substituted 6- (1-Aminoethyl)purines via 6-Acetylpurine Derivatives. (1997) (0)
- 5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production (2014) (0)
- Synthesis of Acyclic Nucleotide Analogues Derived from 2-(Aminomethyl) adenine and 2-(Aminomethyl)hypoxanthine. (1995) (0)
- Efficient Synthesis and Biological Properties of Base Substituted 2,4-Diamino-6-(R)-[3-hydroxy-2-(phosphonomethoxy)propoxy]pyrimidine (HPMPO-DAPy) (2010) (0)
- Tricyclic etheno analogs of purines derived from 2-amino-6-chloropurine (2005) (0)
- Inhibition of cytomegalovirus replication by acyclic nucleoside phosphonate analogues: structure-activity relationship (1991) (0)
- Synthesis of Racemic 2-Hydroxy-4- and 2-Hydroxy-5-(hydroxymethyl)cyclohexane Pyrimidine C-Nucleoside Analogues. (2004) (0)
- Kinetics of Binding of Multisubstrate Analogue Inhibitor (2-Amino-9-[2-(Phosphonomethoxy)Ethyl]-6-Sulfanylpurine) with Trimeric Purine Nucleoside Phosphorylase (2007) (0)
- Foerfarande Foer framstaellning of the -fosfonylmetoxialkylpyrimidiner Science -puriner. (1987) (0)
- N-fosfonylmetoxialkylpyrimidiner Science -puriner. (1987) (0)
- Syntheses with Anhydro Sugars. Part 38. Utilization of 1,6-Anhydrohexoses for the Preparation of Some Aliphatic Adenosine Analogues. (1990) (0)
- Synthesis of Quaternary 1-[2-(Phosphonomethoxy)ethyl] Derivatives of 2,4-Diaminopyrimidine and Related Acyclic Nucleotide Analogues (1999) (0)
- Synthesis of 2-deoxy-D-ribofuranosyl 5-amino- and 5-hydroxyaminoimidazole nucleosides by chemical methods and biotransformation. (1989) (0)
- Synthesis of Racemic 2‐Hydroxy‐4‐ and 2‐Hydroxy‐5‐(hydroxymethyl)cyclohexane Nucleoside Analogues. (2003) (0)
- STUDIES ON S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. II. PREPARATION OF ALIPHATIC ANALOGS OF S-ADENOSYL-L-HOMOCYSTEINE AND RELATED COMPOUNDS (1982) (0)
- Preparation of 9‐(2‐Phosphonomethoxyethyl)adenine Esters as Potential Prodrugs. (2010) (0)
- Pyrimidine compounds with phosphonate as antiviral nucleotide analogues (2004) (0)
- Extent of Intramolecular Pi-Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexs Formed by Heteroaromatic Amines and Several 2-Aminopurine Derivatives of the Antivirally Active Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA). (Ternary Complexes in Solution. Part 71) (2012) (0)
- NEWER TYPES OF BIOLOGICALLY ACTIVE NUCLEOSIDE ANTIGEN METABOLITES (1979) (0)
- Susceptibility of Human Cytomegalovirus (HCMV) Drug-resistant Viruses to a New Class of Acyclic Nucleoside Phosphonate Analogues (ANPs) (2008) (0)
- Analogs of pyrimidin-2-one nucleosides and their enzymatic galactosylation (2008) (0)
- Interaction between Dehydrogenases and a New NAD⊕-Isomer (1975) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGUES PART 159, SYNTHESIS OF SOME 2‐PYRIMIDONE NUCLEOSIDES (1973) (0)
- S-Adenosyl-L-homocysteine Hydrolase. Part 16. 9-(Aminoalkyl)-8-hydroxyadenines: Preparation, Mechanism of Formation and Use in Affinity Chromatography of S-Adenosyl-L-homocysteine Hydrolase. (1986) (0)
- Cytostatic 6-Arylpurine Nucleosides. Part 4. Synthesis of 2-Substituted 6-Phenylpurine Ribonucleosides. (2002) (0)
- The mechanism of isotopic exchange reaction of hydrogen H-5 of uracil derivatives in water and in non-protic solvents (2011) (0)
- Synthesis of 8‐Amino‐ and N‐Substituted 8‐Aminoadenine Derivatives of Acyclic Nucleoside and Nucleotide Analogues. (2001) (0)
- Metalation of 6-halo-2,4-dimethoxypyrimidines as the key step for the synthesis of biologicaly active compounds (2008) (0)
- Reductive Cyclization of 6-Cyanomethyl-5-nitropyrimidines - An Efficient Route to 7-Alkyl-5H-pyrrolo(3,2-d)pyrimidines and 6-Amino-7, 7-dialkyl-7H-pyrrolo(3,2-d)pyrimidines. Utilization in the Synthesis of 9-Deaza Analogues of DHPA. (1997) (0)
- New amphiphilic prodrugs of adefovir and cidofovir (2011) (0)
- Acyclic nucleoside phosphonates as inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase: new anti-malarial chemotherapy leads (2011) (0)
- Remedies with antiviral effective (1978) (0)
- Affinity chromatography of guanyloribonuclease from streptomyces aureofaciens (1980) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGS. CLXXXV. NEW SYNTHESIS OF RIBONUCLEOSIDE CARBOCYCLIC ANALOGS (1976) (0)
- Bifunctional Acyclic Nucleoside Phosphonates. Part 2. Symmetrical 2-{[Bis(phosphono)methoxy]methyl}ethyl Derivatives of Purines and Pyrimidines. (2007) (0)
- Synthesis and antiviral evaluation of 9-(RS)-[2-phosphonylmethoxy-3-(2-propoxy)propyl]adenine (1991) (0)
- P39. NO-upregulating and cytokine-stimulating activity of antiviral nucleotide analogues (2008) (0)
- Structure of 1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine: An Antiviral Agent (1992) (0)
- IMMUNOSUPPRESSANT ANTIGEN CONJUGATES. XXVI. SYNTHESIS OF CONJUGATES OF 5′-O-(CARBOXYMETHYL)-5-HALO-2′-DEOXYURIDINES AND 5′-O-(CARBOXYMETHYL)-5-HALOURIDINES WITH PROTEINS (1980) (0)
- The Synthesis of the 8-C-Substituted 2,6-Diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) Derivatives by Diverse Cross-Coupling Reactions. (2011) (0)
- NUCLEIC ACID COMPONENTS AND THEIR ANALOGUES PART 170, PREPARATION OF 6‐METHYLURIDINE, 6‐ETHYLURIDINE, AND 2′‐DEOXY‐6‐ETHYLURIDINE (1975) (0)
- SUBSTRATE SPECIFITY OF SPLEEN ACID EXONUCLEASE AND SPLEEN CYCLIC PHOSPHODIESTERASE (1974) (0)
- Synthesis and antiviral activity of some 2'-C-alkyl derivatives of 9-(2-phosphonomethoxyethyl)adenine (1993) (0)
- IMMUNOSUPPRESSANT ANTIGENE CONJUGATES PART 6, CARBOXYMETHYLATED URACIL, 2′-DEOXYURIDINE AND THEIR 5-FLUORO, 5-BROMO, AND 5-IODO DERIVATIVES (1975) (0)
- Synthesis of 5‐Phenyl‐2(1H)‐pyrimidinone Nucleosides. (1996) (0)
- Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives. (2007) (0)
- Nucleotide analogs for the treatment of viral infections (1996) (0)
- STUDIES ON S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. IV. STEREOSPECIFIC SYNTHESIS OF ISOMERIC 4-SUBSTITUTED 9-(2,3-DIHYDROXYBUTYL)ADENINES (1982) (0)
- Synthesis of Acyclic Nucleoside and Nucleotide Analogues Derived from 6‐Amino‐7H‐purin‐8(9H)‐one. (2001) (0)
- 9- (phosphonylmethoxyalkyl) -adenine, methods for their manufacture and their use. (1986) (0)
- Isomeric o-phosphonylmethylic derivatives of enantiomeric and racemic vicinal diols and process for their preparation (1984) (0)
- Inhibition of HIV Replication and Enhancement of Immune Functions by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonyl-Methoxyethyl)Adenine (PMEA) (1993) (0)
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