Antonina Roll-Mecak
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Romanian American molecular biophysicist
Antonina Roll-Mecak's AcademicInfluence.com Rankings
Antonina Roll-Mecakphysics Degrees
Physics
#8575
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#10820
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Biophysics
#388
World Rank
#400
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Physics
Antonina Roll-Mecak's Degrees
- PhD Biophysics University of Bucharest
Why Is Antonina Roll-Mecak Influential?
(Suggest an Edit or Addition)According to Wikipedia, Antonina Roll-Mecak is a Romanian-born American molecular biophysicist. She is currently the Senior Investigator and Chief of the Unit of Cell Biology and Biophysics at the National Institutes of Health. She holds appointments at the National Institute of Neurological Disorders and Stroke; and at the Biochemistry and Biophysics Center of the National Heart, Lung and Blood Institute. Roll-Mecak is known for her work in understanding cytoskeletal regulation, mechanisms of microtubule dynamics and laying the groundwork for deciphering the complexities of the tubulin code. She is also known for her work on microtubule severing enzymes spastin and Katanin.
Antonina Roll-Mecak's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin (2008) (293)
- X-Ray Structures of the Universal Translation Initiation Factor IF2/eIF5B Conformational Changes on GDP and GTP Binding (2000) (199)
- Microtubule-severing enzymes (2010) (177)
- The Drosophila Homologue of the Hereditary Spastic Paraplegia Protein, Spastin, Severs and Disassembles Microtubules (2005) (175)
- Graded Control of Microtubule Severing by Tubulin Glutamylation (2016) (174)
- Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase (2014) (172)
- Writing and Reading the Tubulin Code* (2015) (160)
- The chemical complexity of cellular microtubules: Tubulin post‐translational modification enzymes and their roles in tuning microtubule functions (2012) (145)
- Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation (2018) (131)
- Tubulin isoform composition tunes microtubule dynamics (2017) (122)
- Uncoupling of Initiation Factor eIF5B/IF2 GTPase and Translational Activities by Mutations that Lower Ribosome Affinity (2002) (121)
- Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2α Protein Kinase GCN2*[boxs] (2005) (109)
- Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin (2011) (103)
- Data publication with the structural biology data grid supports live analysis (2016) (103)
- The Tubulin Code in Microtubule Dynamics and Information Encoding. (2020) (100)
- Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays? (2006) (100)
- Microtubule-severing enzymes: From cellular functions to molecular mechanism (2018) (98)
- Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin*♦ (2016) (94)
- Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. (1999) (94)
- Intrinsically disordered tubulin tails: complex tuners of microtubule functions? (2015) (84)
- Physical and Functional Interaction between the Eukaryotic Orthologs of Prokaryotic Translation Initiation Factors IF1 and IF2 (2000) (80)
- Katanin spiral and ring structures shed light on power stroke for microtubule severing (2017) (78)
- Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations (2016) (76)
- Engaging the ribosome: universal IFs of translation. (2001) (71)
- X-ray Structure of Translation Initiation Factor eIF2γ (2004) (67)
- Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases (2015) (67)
- How cells exploit tubulin diversity to build functional cellular microtubule mosaics. (2019) (53)
- The tubulin code in neuronal polarity (2018) (42)
- An allosteric network in spastin couples multiple activities required for microtubule severing (2019) (40)
- ER proteins decipher the tubulin code to regulate organelle distribution (2021) (34)
- α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics. (2021) (33)
- Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography (2020) (33)
- Katanin Grips the β-Tubulin Tail through an Electropositive Double Spiral to Sever Microtubules. (2019) (33)
- Crystal Structures of Tubulin Acetyltransferase Reveal a Conserved Catalytic Core and the Plasticity of the Essential N Terminus* (2012) (32)
- X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding. (2004) (28)
- X-ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding (2002) (27)
- Structural determinants of microtubule minus end preference in CAMSAP CKK domains (2019) (25)
- Generation of differentially modified microtubules using in vitro enzymatic approaches. (2014) (24)
- Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes (2020) (20)
- X‐ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1) (2002) (20)
- Universal translation initiation factor IF2/eIF5B. (2001) (19)
- In vitro microtubule severing assays. (2013) (18)
- Generation of Differentially Modified Microtubules using in vitro Enzymatic Approaches (2015) (16)
- Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases (2017) (13)
- Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro. (2013) (13)
- Phosphinic acid-based inhibitors of tubulin polyglutamylases. (2013) (8)
- Shining Light at Microtubule Crossroads (2013) (5)
- Molecular Basis for Age-Dependent Microtubule Acetylation (2015) (5)
- Watching microtubules grow one tubulin at a time (2019) (4)
- Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing. (2022) (4)
- A Microtubule-Myelination Connection (2019) (4)
- An allosteric network in spastin couples multiple activities required for microtubule severing (2019) (3)
- In Vitro Microtubule Dynamics Assays Using Dark-Field Microscopy. (2020) (2)
- In Vitro Reconstitution Assays of Microtubule Amplification and Lattice Repair by the Microtubule-Severing Enzymes Katanin and Spastin. (2019) (1)
- A Real-Space Method to Measure the Persistence Length of Dynamic Microtubules (2020) (1)
- Editorial overview: Microtubules in nervous system development (2021) (1)
- Faculty Opinions recommendation of The In Situ Structure of Parkinson's Disease-Linked LRRK2. (2020) (1)
- Phosphinic acid-based inhibitors of tubulin polyglycylation. (2022) (1)
- A look under the hood of the machine that makes cilia beat (2022) (1)
- Faculty Opinions recommendation of Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation. (0)
- HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule (2019) (0)
- Author Correction: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes (2020) (0)
- Readout of the Tubulin Code by Cellular Effectors: Graded Control of Microtubule Severing by Tubulin Glutamylation (2017) (0)
- Katanin hexamer in the ring conformation (2017) (0)
- TTLL6 bound to alpha-elongation analog (2020) (0)
- Engineered TTLL6 mutant bound to gamma-elongation analog (2020) (0)
- Publisher Correction: ER proteins decipher the tubulin code to regulate organelle distribution (2022) (0)
- Katanin hexamer in the spiral conformation in complex with substrate (2019) (0)
- Structure of the TTLL3 Glycylase (2017) (0)
- Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form. (2005) (0)
- Katanin hexamer in the ring conformation with resolved protomer one in complex with substrate (2019) (0)
- Katanin hexamer in the ring conformation in complex with substrate (2019) (0)
- Engineered TTLL6 bound to the initiation analog (2020) (0)
- Faculty Opinions recommendation of The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin. (2013) (0)
- Cryo-EM structure of tsA201 cell alpha1B and betaI and betaIVb microtubules (2017) (0)
- ER proteins decipher the tubulin code to regulate organelle distribution (2021) (0)
- Engineered TTLL6 mutant bound to alpha-elongation analog (2020) (0)
- Glutamylation is a negative regulator of microtubule growth. (2023) (0)
- TTLL6 bound to gamma-elongation analog (2020) (0)
- Faculty Opinions recommendation of The molecular structure of mammalian primary cilia revealed by cryo-electron tomography. (2020) (0)
- Structural basis for autoinhibition and activation of eIF2α protein kinase GCN2 (2005) (0)
- Faculty Opinions recommendation of Site-specific chemistry on the microtubule polymer. (2013) (0)
- katanin AAA ATPase domain (2017) (0)
- TTLL6 bound to the initiation analog (2020) (0)
- X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B COMPLEXED WITH GDPNP (2000) (0)
- Crystal Structure of eIF2alpha Protein Kinase GCN2: D835N Inactivating Mutant in Apo Form (2005) (0)
- TTLL6 bound to ATP (2020) (0)
- X-Ray Diffraction data from Human Tubulin Acetyltransferase in complex with bisubstrate analog, source of 4PK2 structure (2015) (0)
- Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type in Apo Form. (2005) (0)
- Spastin hexamer in complex with substrate (2019) (0)
- Effects of Added Divalent Counterions on the Properties and Behaviors of Microtubule Filaments (2015) (0)
- Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing (2020) (0)
- Tubulin acetyltransferase mutant (2012) (0)
- Faculty Opinions recommendation of Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating. (2021) (0)
- Tubulin tyrosine ligase - structural and functional studies (2014) (0)
- NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule (2019) (0)
- Publisher Correction: ER proteins decipher the tubulin code to regulate organelle distribution (2022) (0)
- Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type Complexed with ATP. (2005) (0)
- Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant Complexed with AMPPNP. (2005) (0)
- Microtubule chemical complexity: mechanism of tubulin modification enzymes (2014) (0)
- katanin hexamer in spiral conformation (2017) (0)
- NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule (2019) (0)
- tubulin acetyltransferase complex with bisubstrate analog (2014) (0)
- Molecular Basis for Age-Dependent Acetylation by Tubulin Acetyltransferase (2015) (0)
- Microtubule dynamics: 50 years after the discovery of tubulin and still going strong (2017) (0)
- associated Microtubule-severing enzymes (2022) (0)
- Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing (2020) (0)
- HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule (2019) (0)
- X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B (2000) (0)
- Crystal structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1) (2002) (0)
- Microtubule-severing enzymes. (2022) (0)
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Antonina Roll-Mecak is affiliated with the following schools:
