Antonius J. M. De Craen

Antonius J. M. De Craen's AcademicInfluence.com Rankings

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#9888

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#13510

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#6838

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#8392

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Philosophy

Antonius J. M. De Craen's Degrees

PhD Medicine Leiden University

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Antonius J. M. De Craen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Thyroid status, disability and cognitive function, and survival in old age. (2004) (826)
The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials (2009) (781)
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity (2016) (634)
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. (2010) (500)
Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population. (2011) (483)
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA (2016) (471)
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease (2016) (434)
Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. (2008) (350)
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study (2010) (339)
Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study (2009) (332)
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) (2015) (328)
Accuracy of the 15‐item geriatric depression scale (GDS‐15) in a community sample of the oldest old (2003) (327)
Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study. (2002) (327)
Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers (2013) (307)
The impact of low-frequency and rare variants on lipid levels (2015) (300)
Systemic Markers of Inflammation and Cognitive Decline in Old Age (2007) (295)
Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population (2006) (280)
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited (2011) (273)
Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos (2000) (264)
The Genome of the Netherlands: design, and project goals (2013) (260)
Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study (2009) (255)
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age (2014) (238)
Novel genetic loci associated with hippocampal volume (2017) (238)
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension (2016) (234)
A high response is not essential to prevent selection bias: results from the Leiden 85-plus study. (2002) (227)
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. (2018) (221)
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins (2014) (207)
The metabolic syndrome is associated with decelerated cognitive decline in the oldest old (2007) (195)
A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function (2013) (193)
Novel genetic loci underlying human intracranial volume identified through genome-wide association (2016) (192)
Progression of brain atrophy and cognitive decline in diabetes mellitus (2010) (191)
The number of p16INK4a positive cells in human skin reflects biological age (2012) (188)
Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. (2012) (186)
Cerebral blood flow in small vessel disease: A systematic review and meta-analysis (2016) (182)
Inflammation and Stroke: The Leiden 85-Plus Study (2002) (180)
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels (2015) (179)
Association between high‐density lipoprotein and cognitive impairment in the oldest old (2002) (177)
Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study. (2005) (175)
Walking and Talking as Predictors of Falls in the General Population: The Leiden 85‐Plus Study (2003) (174)
Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk. (2012) (174)
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. (2011) (167)
Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. (2005) (166)
Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. (2008) (166)
Hallmark Features of Immunosenescence Are Absent in Familial Longevity (2010) (160)
Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study (2013) (157)
Use of Aspirin postdiagnosis improves survival for colon cancer patients (2012) (154)
Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state (2010) (153)
The controversies of statin therapy: weighing the evidence. (2012) (152)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017) (149)
Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study (2009) (148)
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels (2016) (147)
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity (2010) (146)
Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review (1996) (146)
Placebo effect in the treatment of duodenal ulcer. (1999) (140)
Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI (2015) (139)
Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study (2013) (130)
Effects of a Web-Based Intervention on Physical Activity and Metabolism in Older Adults: Randomized Controlled Trial (2013) (129)
Multifocal vulvar intraepithelial neoplasia grade III and multicentric lower genital tract neoplasia is associated with transcriptionally active human papillomavirus (1995) (125)
ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age (2006) (124)
Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. (2009) (120)
Common Chronic Diseases and General Impairments as Determinants of Walking Disability in the Oldest‐Old Population (2002) (119)
Living with epilepsy (2003) (116)
Familial longevity is associated with decreased thyroid function. (2010) (115)
Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning--the DANTE Study Leiden: A Randomized Clinical Trial. (2015) (114)
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways (2011) (112)
Why use placebos in clinical trials? A narrative review of the methodological literature. (2000) (111)
Are Markers of Inflammation More Strongly Associated with Risk for Fatal Than for Nonfatal Vascular Events? (2009) (109)
Gene expression analysis of mTOR pathway: association with human longevity (2013) (108)
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age (2005) (107)
Cerebral Microbleeds Are Predictive of Mortality in the Elderly (2011) (105)
Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia. (2005) (102)
Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities. (2007) (102)
Sensory impairment and cognitive functioning in oldest-old subjects: the Leiden 85+ Study. (2005) (99)
Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults (2014) (94)
Effect of pravastatin on cerebral infarcts and white matter lesions (2005) (92)
Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers (2014) (92)
Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement. (2006) (91)
Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people (2012) (90)
Vascular disease and apathy in old age. The Leiden 85‐plus Study (2008) (89)
Leptin Predicts Diabetes but Not Cardiovascular Disease (2009) (88)
Performing Survival Analyses in the Presence of Competing Risks: A Clinical Example in Older Breast Cancer Patients. (2016) (85)
Temporal relationship between handgrip strength and cognitive performance in oldest old people. (2012) (82)
Lack of survival gain for elderly women with breast cancer. (2011) (81)
Postoperative complications and survival of elderly breast cancer patients: a FOCUS study analysis (2013) (81)
Different progression rates for deep white matter hyperintensities in elderly men and women (2004) (81)
Validity of Adjuvant! Online program in older patients with breast cancer: a population-based study. (2014) (80)
Genomics of human longevity (2011) (80)
Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study. (2008) (78)
Does subfertility explain the risk of poor perinatal outcome after IVF and ovarian hyperstimulation? (2006) (76)
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. (2008) (76)
Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. (2010) (76)
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. (2016) (75)
Human insulin/IGF-1 and familial longevity at middle age (2009) (75)
Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study. (2002) (74)
Circulating Interleukin-10 and Risk of Cardiovascular Events: A Prospective Study in the Elderly at Risk (2011) (74)
Impact of physical and mental health on life satisfaction in old age: a population based observational study (2016) (72)
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation (2015) (72)
Disability in the Oldest Old: “Can Do” or “Do Do”? (2001) (72)
Blood Pressure Variability and Cardiovascular Risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) (2012) (71)
Co‐occurrence of depression and anxiety in elderly subjects aged 90 years and its relationship with functional status, quality of life and mortality (2009) (71)
Quality–quantity trade‐off of human offspring under adverse environmental conditions (2009) (70)
Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function (2003) (70)
Increase in hospital admission rates for heart failure in The Netherlands, 1980-1993. (1996) (70)
Subclinical Thyroid Dysfunction and Cognitive Decline in Old Age (2013) (67)
Not all age-related white matter hyperintensities are the same: a magnetization transfer imaging study. (2006) (67)
External validity of a trial comprised of elderly patients with hormone receptor-positive breast cancer. (2014) (66)
Predicting survival in oldest old people. (2012) (64)
Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults (2011) (63)
Blood pressure and 10-year mortality risk in the Milan Geriatrics 75+ Cohort Study: role of functional and cognitive status. (2015) (63)
High Blood Pressure, Physical and Cognitive Function, and Risk of Stroke in the Oldest Old: The Leiden 85-Plus Study (2013) (62)
Validity of the online PREDICT tool in older patients with breast cancer: a population-based study (2016) (62)
Scientific output of Dutch medical students (2010) (62)
Progression of cerebral white matter lesions is not associated with development of depressive symptoms in elderly subjects at risk of cardiovascular disease. The PROSPER Study (2006) (62)
The Effect of Three-Monthly Albendazole Treatment on Malarial Parasitemia and Allergy: A Household-Based Cluster-Randomized, Double-Blind, Placebo-Controlled Trial (2013) (62)
Surgical treatment of early stage breast cancer in elderly: an international comparison (2011) (61)
Innate production of tumour necrosis factor α and interleukin 10 is associated with radiological progression of knee osteoarthritis (2007) (59)
Reduced Glomerular Filtration Rate and Its Association with Clinical Outcome in Older Patients at Risk of Vascular Events: Secondary Analysis (2009) (59)
Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study. (2009) (58)
Does Low to Moderate Alcohol Intake Protect Against Cognitive Decline in Older People? (2008) (58)
Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation. (2005) (58)
Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects (2016) (57)
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. (2008) (57)
PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population[S] (2013) (57)
Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature (2017) (57)
Cognitive Impairment and Risk of Stroke: A Systematic Review and Meta-Analysis of Prospective Cohort Studies (2014) (57)
No influence of melatonin on cerebral blood flow in humans. (2003) (55)
Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses (2011) (53)
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts (2017) (53)
No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85‐plus Study (2002) (53)
The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes. (2011) (53)
Increased amygdalar and hippocampal volumes in elderly obese individuals with or at risk of cardiovascular disease. (2011) (53)
Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study (2013) (53)
Disability transitions in the oldest old in the general population. The Leiden 85-plus study (2013) (53)
Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality (2011) (53)
Late-onset dementia: structural brain damage and total cerebral blood flow. (2005) (52)
Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study (2015) (52)
Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women. (2011) (51)
Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly[S] (2010) (51)
Comparison of frequencies and prognostic effect of molecular subtypes between young and elderly breast cancer patients (2014) (51)
Blood pressure trends and mortality: the Leiden 85-plus Study (2013) (50)
Sustained beneficial metabolic effects 18 months after a 30-day very low calorie diet in severely obese, insulin-treated patients with type 2 diabetes. (2007) (50)
Microstructural Brain Tissue Damage in Metabolic Syndrome (2014) (49)
Resting heart rate, heart rate variability and functional decline in old age (2015) (48)
Routine use of hysterosalpingography prior to laparoscopy in the fertility workup: a multicentre randomized controlled trial. (2006) (48)
White matter hyperintensities, medial temporal lobe atrophy, cortical atrophy, and response to electroconvulsive therapy in severely depressed elderly patients. (2011) (48)
Subclinical Thyroid Dysfunction and Depressive Symptoms among the Elderly: A Prospective Cohort Study (2015) (48)
Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R (2012) (48)
Long-Term Effects of Statin Treatment in Elderly People: Extended Follow-Up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) (2013) (48)
Characteristics of Randomized Controlled Trials Designed for Elderly: A Systematic Review (2015) (47)
Adherence to treatment guidelines and survival in patients with early‐stage breast cancer by age at diagnosis (2012) (47)
The heart-brain connection: a multidisciplinary approach targeting a missing link in the pathophysiology of vascular cognitive impairment. (2014) (47)
The influence of age on health valuations: the older olds prefer functional independence while the younger olds prefer less morbidity (2015) (47)
Use of benzodiazepines, depressive symptoms and cognitive function in old age (2009) (46)
Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis (2015) (46)
Effect of implementation of the mass breast cancer screening programme in older women in the Netherlands: population based study (2014) (46)
Associations between Total Cerebral Blood Flow and Age Related Changes of the Brain (2010) (46)
10-Second heart rate variability and cognitive function in old age (2016) (45)
Thyroid status and renal function in older persons in the general population. (2014) (45)
Diabetes in relation to breast cancer relapse and all-cause mortality in elderly breast cancer patients: a FOCUS study analysis. (2013) (45)
Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives. (2012) (45)
White blood cell count and C-reactive protein are independent predictors of mortality in the oldest old. (2010) (45)
Genetic Variation in the Interleukin‐10 Gene Promoter and Risk of Coronary and Cerebrovascular Events (2007) (45)
Effect of discontinuation of antihypertensive medication on orthostatic hypotension in older persons with mild cognitive impairment: the DANTE Study Leiden. (2016) (44)
The effect of cognitive impairment on the predictive value of multimorbidity for the increase in disability in the oldest old: the Leiden 85-plus Study (2011) (44)
Age-specific nonpersistence of endocrine therapy in postmenopausal patients diagnosed with hormone receptor-positive breast cancer: a TEAM study analysis. (2012) (44)
An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial (2016) (44)
Activation of Hemostasis and Decline in Cognitive Function in Older People (2010) (43)
Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels (2015) (43)
Physical activity and survival of postmenopausal, hormone receptor–positive breast cancer patients: Results of the Tamoxifen Exemestane Adjuvant Multicenter Lifestyle study (2014) (43)
Higher blood pressure is associated with higher handgrip strength in the oldest old. (2011) (43)
High serum glucose levels are associated with a higher perceived age (2011) (42)
Age-related changes in normal-appearing brain tissue and white matter hyperintensities: more of the same or something else? (2005) (42)
Temporal Relationship Between Cognitive and Physical Performance in Middle-Aged to Oldest Old People (2016) (41)
Performance of Cockcroft-Gault, MDRD, and CKD-EPI in estimating prevalence of renal function and predicting survival in the oldest old (2013) (41)
Restricted surgical management of vulvar intraepithelial neoplasia 3: Focus on exclusion of invasion and on relief of symptoms. (1998) (41)
LDL cholesterol still a problem in old age? A Mendelian randomization study. (2015) (41)
Clinical outcome after standardized versus dosimetric radioiodine treatment of hyperthyroidism: an equivalence study (2000) (41)
Framingham Stroke Risk Score and Cognitive Impairment for Predicting First-Time Stroke in the Oldest Old (2013) (40)
Cognitive decline precedes late-life longitudinal changes in vascular risk factors (2010) (40)
Serum triiodothyronine levels and inflammatory cytokine production capacity (2011) (40)
Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer (2012) (39)
Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2 (2014) (39)
The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study (2017) (39)
Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals. (2013) (38)
Aspirin Use After Diagnosis Improves Survival in Older Adults with Colon Cancer: A Retrospective Cohort Study (2012) (38)
Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2. (2016) (38)
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
Human Papillomavirus DNA in Multicentric Vulvar Intraepithelial Neoplasia (1998) (37)
Early prediction of hospital admission for emergency department patients: a comparison between patients younger or older than 70 years (2017) (36)
Effects of a stepped-care intervention programme among older subjects who screened positive for depressive symptoms in general practice: the PROMODE randomised controlled trial. (2012) (36)
Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative (2017) (35)
Association between chronic diseases and disability in elderly subjects with low and high income: the Leiden 85-plus Study. (2005) (35)
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels (2016) (34)
Haemoglobin predicts length of hospital stay after hip fracture surgery in older patients. (2012) (33)
Genome-Wide Study of Gene Variants Associated with Differential Cardiovascular Event Reduction by Pravastatin Therapy (2012) (32)
KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. (2011) (32)
Risk Factors for Cerebral Microbleeds in the Elderly (2008) (32)
Physical Functioning in Older Patients With Breast Cancer: A Prospective Cohort Study in the TEAM Trial. (2016) (31)
The value of Chlamydia trachomatis-specific IgG antibody testing and hysterosalpingography for predicting tubal pathology and occurrence of pregnancy. (2007) (31)
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins (2016) (31)
Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals (2015) (31)
NT-proBNP, blood pressure, and cognitive decline in the oldest old (2014) (30)
Homocysteine Levels and Treatment Effect in the Prospective Study of Pravastatin in the Elderly at Risk (2014) (29)
Adverse environmental conditions influence age-related innate immune responsiveness (2009) (29)
The survival gap between middle-aged and elderly colon cancer patients. Time trends in treatment and survival. (2011) (29)
Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity: The Leiden Longevity Study (2013) (28)
Impact of omission of surgery on survival of older patients with breast cancer (2014) (28)
Evidence-based medicine in older patients: how can we do better? (2015) (28)
White matter hyperintensities and cognitive impairment during electroconvulsive therapy in severely depressed elderly patients. (2014) (28)
Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations (2019) (28)
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval (2013) (27)
Blood Pressure Is Not Associated With Cerebral Blood Flow in Older Persons (2015) (27)
Familial Longevity Is Marked by Lower Diurnal Salivary Cortisol Levels: The Leiden Longevity Study (2012) (27)
C-Reactive Protein and Genetic Variants and Cognitive Decline in Old Age: The PROSPER Study (2011) (27)
The contribution of MIB 1 in the accurate grading of vulvar intraepithelial neoplasia. (1999) (27)
Executive function, but not memory, associates with incident coronary heart disease and stroke (2015) (27)
Plasma Levels of Apolipoprotein E and Risk of Stroke in Old Age (2007) (27)
Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study (2010) (27)
Pravastatin Decreases Wall Shear Stress and Blood Velocity in the Internal Carotid Artery Without Affecting Flow Volume: Results From the PROSPER MRI Study (2007) (26)
Plasma apolipoprotein CI protects against mortality from infection in old age. (2008) (25)
Total cerebral blood flow and mortality in old age (2013) (25)
Low thyroid function is not associated with an accelerated deterioration in renal function. (2019) (25)
Performance of the whole-blood stimulation assay for assessing innate immune activation under field conditions. (2009) (25)
Impact of experimentally-induced expectancy on the analgesic efficacy of tramadol in chronic pain patients: a 2 x 2 factorial, randomized, placebo-controlled, double-blind trial. (2001) (25)
Lack of Effect of Pravastatin on Cerebral Blood Flow or Parenchymal Volume Loss in Elderly at Risk for Vascular Disease (2005) (25)
Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies (2015) (25)
Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study (2017) (24)
Diastolic Carotid Artery Wall Shear Stress Is Associated With Cerebral Infarcts and Periventricular White Matter Lesions (2011) (24)
Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study (2013) (24)
Dose-Response Effects of a Web-Based Physical Activity Program on Body Composition and Metabolic Health in Inactive Older Adults: Additional Analyses of a Randomized Controlled Trial (2014) (24)
High Innate Production Capacity of Proinflammatory Cytokines Increases Risk for Death from Cancer: Results of the PROSPER Study (2009) (24)
Predictive Value of a Profile of Routine Blood Measurements on Mortality in Older Persons in the General Population: The Leiden 85-Plus Study (2013) (23)
Low-cost interventions accelerate epidemiological transition in Upper East Ghana. (2009) (23)
Time trends in chemotherapy (administration and costs) and relative survival in stage III colon cancer patients – a large population-based study from 1990 to 2008 (2013) (23)
CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival. (2015) (23)
Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies (2010) (23)
Elderly postmenopausal patients with breast cancer are at increased risk for distant recurrence: a tamoxifen exemestane adjuvant multinational study analysis. (2013) (23)
Lower Blood Pressure Is Associated With Smaller Subcortical Brain Volumes in Older Persons. (2015) (22)
Assistive devices and community-based services among 85-year-old community-dwelling elderly in The Netherlands: Ownership, use,and need for intervention (2006) (22)
Handgrip strength at midlife and familial longevity (2011) (22)
Establishing a composite endpoint for measuring the effectiveness of geriatric interventions based on older persons’ and informal caregivers’ preference weights: a vignette study (2014) (22)
Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study (2010) (21)
White Matter Lesion Progression: Genome-Wide Search for Genetic Influences (2015) (21)
Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) (2011) (21)
TAC-TIC use of tacrolimus-based regimens in lupus nephritis (2016) (21)
Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age. (2015) (20)
Copy number variation associates with mortality in long‐lived individuals: a genome‐wide assessment (2015) (20)
Personalized absolute benefit of statin treatment for primary or secondary prevention of vascular disease in individual elderly patients (2016) (20)
Dynamics of traditional metabolic risk factors associate with specific causes of death in old age. (2010) (20)
Prediction of 90-day mortality in older patients after discharge from an emergency department: a retrospective follow-up study (2016) (19)
Increased C‐reactive protein is not associated with apathy: the Leiden 85‐Plus Study (2009) (19)
Association of the fat mass and obesity‐associated gene risk allele, rs9939609A, and reward‐related brain structures (2015) (19)
High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk (2016) (19)
Predicting mortality in acutely hospitalized older patients: a retrospective cohort study (2016) (19)
Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium (2015) (19)
Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study (2011) (19)
Cerebral Microbleeds and Lacunar Infarcts Are Associated with Walking Speed Independent of Cognitive Performance in Middle-Aged to Older Adults (2016) (19)
An unopposed proinflammatory response is beneficial for survival in the oldest old. Results of the Leiden 85-plus Study. (2011) (18)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) ameliorates chemotherapy-induced neutropenia in children with solid tumors. (1997) (18)
TNF-α antagonist infliximab in the treatment of depression in older adults: results of a prematurely ended, randomized, placebo-controlled trial. (2010) (18)
NT-proBNP Best Predictor of Cardiovascular Events and Cardiovascular Mortality in Secondary Prevention in Very Old Age: The Leiden 85-Plus Study (2013) (18)
An analysis of systematic reviews indicated low incorpororation of results from clinical trial quality assessment. (2005) (18)
Prognostic value of cardiovascular disease status: the Leiden 85-plus study (2012) (17)
Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study (2012) (17)
Treatment Strategies and Survival of Older Breast Cancer Patients – An International Comparison between the Netherlands and Ireland (2015) (17)
Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study. (2006) (17)
Serum insulin‐like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross‐sectional study (2013) (17)
Visit-to-visit blood pressure variability and future functional decline in old age (2016) (17)
Management of primary metastatic breast cancer in elderly patients--an international comparison of oncogeriatric versus standard care. (2014) (16)
Plasma Levels of Apolipoprotein E and Cognitive Function in Old Age (2007) (16)
Familial Resemblance for Serum Metabolite Concentrations (2013) (16)
Prevalence of five common clinical abnormalities in very elderly people: population based cross sectional study (2003) (16)
Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease. (2015) (16)
Assessing treatment effects in older breast cancer patients: systematic review of observational research methods. (2015) (16)
APOE genotype modulates the effect of serum calcium levels on cognitive function in old age (2009) (16)
[Thyroid function, activities of daily living and survival in extreme old age: the 'Leiden 85-plus Study']. (2006) (16)
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance (2014) (16)
Associations of Various Health-Ratings with Geriatric Giants, Mortality and Life Satisfaction in Older People (2016) (15)
Evaluation of the Use of Home Blood Pressure Measurement Using Mobile Phone-Assisted Technology: The iVitality Proof-of-Principle Study (2016) (15)
N-terminal pro–brain natriuretic peptide and abnormal brain aging (2015) (15)
The development, implementation and evaluation of a transitional care programme to improve outcomes of frail older patients after hospitalisation. (2016) (15)
Left Ventricular Hypertrophy and Cognitive Decline in Old Age. (2017) (15)
Thyroid Status and Mortality Risk in Older Adults With Normal Thyrotropin: Sex Differences in the Milan Geriatrics 75+ Cohort Study (2016) (14)
Randomised Controlled Trial of Unsolicited Occupational Therapy in Community-Dwelling Elderly People: The LOTIS Trial (2006) (14)
Unilateral fetal-type circle of Willis anatomy causes right–left asymmetry in cerebral blood flow with pseudo-continuous arterial spin labeling: A limitation of arterial spin labeling-based cerebral blood flow measurements? (2016) (14)
ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment. (2014) (14)
Regression Discontinuity Design: Simulation and Application in Two Cardiovascular Trials with Continuous Outcomes (2016) (14)
Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors. (2005) (14)
Seasonal mood variation in the elderly: the Leiden 85‐plus Study (2005) (14)
Risk of depressive symptoms in the oldest old subjects with chronic obstructive pulmonary disease: the Leiden 85-plus study. (2010) (14)
Contralateral breast cancer risk in relation to tumor morphology and age—in which patients is preoperative MRI justified? (2015) (13)
Yield and costs of direct and stepped screening for depressive symptoms in subjects aged 75 years and over in general practice (2011) (13)
Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality (2014) (13)
Survival and relapse free period of 2926 unselected older breast cancer patients: a FOCUS cohort study. (2015) (13)
No increased mortality risk in older persons with unexplained anaemia. (2012) (13)
Longevity Around the Turn of the 20th Century: Life-Long Sustained Survival Advantage for Parents of Today’s Nonagenarians (2018) (13)
Survival of older patients with metastasised breast cancer lags behind despite evolving treatment strategies--a population-based study. (2015) (13)
Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. (2010) (12)
Clinically diagnosed infections predict disability in activities of daily living among the oldest-old in the general population: the Leiden 85-plus Study (2013) (12)
The Science of the Placebo: Toward an Interdisciplinary Research Agenda (2002) (11)
Homocysteine and Familial Longevity: The Leiden Longevity Study (2011) (11)
Parental longevity correlates with offspring’s optimism in two cohorts of community-dwelling older subjects (2011) (11)
Increase in N-terminal pro-brain natriuretic peptide levels, renal function and cardiac disease in the oldest old. (2015) (11)
C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects (2011) (10)
Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R (2012) (10)
Infratentorial Microbleeds: Another Sign of Microangiopathy in Migraine (2015) (10)
The clinical value of HER-2 overexpression and PIK3CA mutations in the older breast cancer population: a FOCUS study analysis (2016) (10)
Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage (2007) (10)
Diastolic Wall Shear Stress in the Internal Carotid Artery Is Associated with Different Cardiovascular Risk Factors than Systolic Wall Shear Stress (2009) (9)
No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects (2014) (9)
PREDICTIVE VALUE OF LOW FERRITIN IN OLDER PERSONS WITH ANEMIA WITH AND WITHOUT INFLAMMATION: THE LEIDEN 85‐PLUS STUDY (2010) (9)
Genetically determined prospect to become long-lived is associated with less abdominal fat and in particular less abdominal visceral fat in men. (2015) (9)
Is there a need to control the placebo in placebo controlled trials? (1997) (9)
Brain tissue volumes in familial longevity: the Leiden Longevity Study (2012) (9)
In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study. (2014) (8)
In depressed older persons higher blood pressure is associated with symptoms of apathy. The NESDO study (2015) (8)
Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared (2016) (7)
Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach. (2009) (7)
Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C (2015) (6)
Prediction of functional decline in community-dwelling older persons in general practice: a cohort study (2018) (6)
Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease (2015) (6)
High Sensitivity Cardiac Troponin T and Cognitive Function in the Oldest Old: The Leiden 85-Plus Study. (2017) (6)
Homocysteine, B vitamins, and cardiovascular disease. (2006) (5)
Forearm blood flow measurements using computerized R-wave triggered strain-gauge venous occlusion plethysmography: unilateral vs. bilateral measurements. (2001) (5)
Helicobacter pylori eradication therapy in The Netherlands. (1999) (5)
Does prostate-specific antigen density alter decision making on biopsy? (1996) (5)
How is Change in Physical Health Status Reflected by Reports of Nurses and Older People Themselves? (2016) (5)
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways (2011) (5)
Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age (2015) (5)
Hematopoietic Capacity and Exceptional Survival: The Leiden Longevity Study (2008) (5)
No Excess Mortality in Patients Aged 50 Years and Older Who Received Treatment for Ductal Carcinoma In Situ of the Breast (2012) (5)
Risk stratification and treatment effect of statins in secondary cardiovascular prevention in old age: Additive value of N-terminal pro-B-type natriuretic peptide (2016) (4)
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene (2019) (4)
Cholesterol and risk of stroke: Cholesterol, stroke, and age (2006) (4)
[Causes of health and disease in old age: new insights from the Leiden Research Program on Ageing]. (2009) (3)
Effect of calendar age on physical performance: A comparison of standard clinical measures with instrumented measures in middle-aged to older adults. (2016) (3)
Plasma NT-proBNP as predictor of change in functional status, cardiovascular morbidity and mortality in the oldest old: the Leiden 85-plus study (2013) (3)
Correction: The Effect of Three-Monthly Albendazole Treatment on Malarial Parasitemia and Allergy: A Household-Based Cluster-Randomized, Double-Blind, Placebo-Controlled Trial (2013) (3)
Total Joint Replacement in the Past Does Not Relate to a Deteriorated Functional Level and Health Status in the Oldest Old (2012) (2)
Difficulties in recruitment for a randomized controlled trial involving hysterosalpingography (2006) (2)
An In Vivo Study on Brain Microstructure in Biological and Chronological Ageing (2015) (2)
Endothelium-Dependent NO-Mediated Vasodilation in Humans is Attenuated by Peripheral α1-Adrenoceptor Activation (2005) (2)
Parental longevity correlates with offspring’s optimism in two cohorts of community-dwelling older subjects (2011) (1)
Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study (2011) (1)
Association of diastolic blood pressure with cardiovascular events in older people varies upon cardiovascular history (2017) (1)
High serum glucose levels are associated with a higher perceived age (2011) (1)
Statins and blood pressure. (2008) (1)
[Causes and consequences of cognitive decline in the very elderly; the 'Leiden 85-plus Study']. (2004) (1)
Serum triiodothyronine levels and inflammatory cytokine production capacity (2011) (1)
Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study (2014) (1)
Handgrip strength at midlife and familial longevity (2011) (1)
Prognostic index for 4-year mortality in older adults. (2006) (1)
Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people (2012) (1)
Disability transitions in the oldest old in the general population. The Leiden 85-plus study (2013) (1)
[Surgical complications in elderly patients with breast cancer]. (2013) (1)
Do Endorphins Mediate Placebo Analgesia? A Critical Commentary on One of the Seminal Papers (1998) (0)
Familial Resemblance for Serum Metabolite Concentrations — Corrigendum (2013) (0)
00072 IS THE ASSUMED NATURAL HISTORY OF VULVAR INTRAEPITHELIAL NEOPLASIA III BASED ON ENOUGH EVIDENCE? A SYSTEMATIC REVIEW OF 3319 PUBLISHED PATIENTS (2005) (0)
P1-391 No excess mortality in patients of 50 years and older who received treatment for carcinoma in situ of the breast (2011) (0)
Correction: Examining the construct and known-group validity of a composite endpoint for The Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A large-scale data sharing initiative (2018) (0)
Prognostic value of cardiovascular disease status: the Leiden 85-plus study (2012) (0)
[Worse prognosis for older breast cancer patients]. (2012) (0)
Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer (2012) (0)
Role of nitric oxide and alpha-adrenergic receptor responsiveness in exercising skeletal muscle. (2005) (0)
C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects (2011) (0)
Statins reduce the risk of cancer-related mortality in cancer-diagnosed patients. A true phenomenon? (2013) (0)
P2-546 Age at diagnosis affects adherence to national breast cancer guidelines regarding local therapy (2011) (0)
Phenotypic and functional immune attributes predicting survival in very elderly people (47.7) (2012) (0)
Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study (2014) (0)
Evidence from case–control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity (2012) (0)
A framework for the detection of de novo mutations in family-based sequencing data (2016) (0)
Correction: Predictive Value of a Profile of Routine Blood Measurements on Mortality in Older Persons in the General Population: The Leiden 85-Plus Study (2015) (0)
The Placebo Effect and Health: Combining Science and Compassionate Care (2006) (0)
Randomized trial of a color-coded slide rule in children with diabetes. (2005) (0)
Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age (2015) (0)
Diagnostic criteria for sarcopenia relate differently to insulin resistance (2013) (0)

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What Schools Are Affiliated With Antonius J. M. De Craen?

Antonius J. M. De Craen is affiliated with the following schools:

Leiden University