Antony Galione

Q: What Schools Are Affiliated With Antony Galione

Antony Galione is affiliated with the following schools: University of Bath, University of Oxford, University College London, Johns Hopkins University, Sapienza University of Rome, University of Cambridge

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Antony Galione

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#203

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#243

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According to Wikipedia, Antony Giuseppe Galione is a British pharmacologist. He is a professor and Wellcome Trust senior investigator in the Department of Pharmacology at the University of Oxford. Early life and education Antony Giuseppe Galione was born on 13 September 1963 in Chelmsford, England, to Angelo and Margaret Galione. He was educated at Felsted School in Essex and Trinity College, Cambridge, where he was awarded a Bachelor of Arts degree in Natural Sciences in 1985 followed by a PhD in 1989 for research on calcium signalling in the salivary gland of the blowfly, supervised by Michael Berridge.

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Antony Galione's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium (2008) (755)
NAADP mobilizes calcium from acidic organelles through two-pore channels (2009) (714)
Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose (1991) (643)
Cytosolic calcium oscillators (1988) (631)
NAADP Mobilizes Ca2+ from Reserve Granules, Lysosome-Related Organelles, in Sea Urchin Eggs (2002) (428)
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells (1999) (367)
cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis (1993) (361)
Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease. (2011) (326)
Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs. (1993) (308)
Identification of a chemical probe for NAADP by virtual screening (2009) (283)
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. (2002) (255)
Nitric Oxide-induced Mobilization of Intracellular Calcium via the Cyclic ADP-ribose Signaling Pathway (*) (1996) (246)
Cyclic ADP-ribose: a new way to control calcium. (1993) (243)
Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking (2010) (234)
Organelle Selection Determines Agonist-specific Ca2+ Signals in Pancreatic Acinar and β Cells* (2004) (219)
TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+* (2010) (204)
Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers (2002) (186)
NAADP induces Ca2+ oscillations via a two‐pool mechanism by priming IP3‐ and cADPR‐sensitive Ca2+ stores (2001) (180)
Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive pool. (1996) (176)
Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate. (2000) (172)
NAADP A New Second Messenger for Glucose-Induced Ca2+ Responses in Clonal Pancreatic β Cells (2003) (167)
Sperm Deliver a New Second Messenger NAADP (2003) (164)
Unique Inactivation Properties of NAADP-sensitive Ca Release (*) (1996) (164)
Lysosome-Sarcoplasmic Reticulum Junctions (2004) (160)
Coordination of Ca2+ signalling by NAADP. (2001) (157)
Interactions between calcium release pathways: multiple messengers and multiple stores. (2002) (156)
Cyclic ADP-ribose, the ADP-ribosyl cyclase pathway and calcium signalling (1994) (152)
Role of NAADP and cADPR in the Induction and Maintenance of Agonist-Evoked Ca2+ Spiking in Mouse Pancreatic Acinar Cells (2005) (152)
ADP-ribosyl Cyclase and Cyclic ADP-ribose Hydrolase Act as a Redox Sensor (2001) (145)
Bidirectional Ca2+ signaling occurs between the endoplasmic reticulum and acidic organelles (2013) (141)
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca2+ signaling (2014) (132)
Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells (2015) (132)
Ca(2+)-induced Ca2+ release and its modulation by cyclic ADP-ribose. (1992) (131)
Nicotinic Acid Adenine Dinucleotide Phosphate Mediates Ca2+ Signals and Contraction in Arterial Smooth Muscle via a Two-Pool Mechanism: RETRACTED (2002) (129)
Activation of Ca(2+)-dependent currents in cultured rat dorsal root ganglion neurones by a sperm factor and cyclic ADP-ribose. (1992) (129)
Calcium signaling via two-pore channels: local or global, that is the question (2009) (125)
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. (2015) (122)
NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing (2012) (120)
Cyclic ADP-ribose: metabolism and calcium mobilizing function. (1994) (116)
Pharmacological properties of the Ca2+‐release mechanism sensitive to NAADP in the sea urchin egg (1997) (115)
Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg*♦ (2011) (115)
Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores. (1999) (114)
NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells. (2007) (114)
Cyclic ADP‐ribose‐induced Ca2+ release from rat brain microsomes (1993) (113)
Anti-Ig-induced Calcium Influx in Rat B Lymphocytes Mediated by cGMP through a Dihydropyridine-sensitive Channel (*) (1996) (112)
A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells. (2015) (110)
The endoplasmic reticulum and junctional membrane communication during calcium signaling. (2013) (107)
The NAADP receptor: new receptors or new regulation? (2005) (107)
Two‐pore channels (TPCs): Current controversies (2014) (103)
A Ca2+ release mechanism gated by the novel pyridine nucleotide, NAADP. (1997) (103)
Nicotinic acid adenine dinucleotide phosphate triggers Ca2+ release from brain microsomes (1999) (102)
NAADP as an intracellular messenger regulating lysosomal calcium-release channels. (2010) (101)
Flipping the switch: How a sperm activates the egg at fertilization (2007) (98)
Intracellular sphingosine releases calcium from lysosomes (2015) (97)
A specific cyclic ADP-ribose antagonist inhibits cardiac excitation–contraction coupling (1996) (97)
Spatial Control of Ca2+ Signaling by Nicotinic Acid Adenine Dinucleotide Phosphate Diffusion and Gradients* (2000) (96)
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels (2009) (95)
NAADP Controls Cross-talk between Distinct Ca2+ Stores in the Heart* (2007) (94)
The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+ Mobilization from Lysosomes in Pancreatic Acinar Cells* (2010) (93)
Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus. (1999) (93)
Nicotinamide inhibits cyclic ADP-ribose-mediated calcium signalling in sea urchin eggs. (1996) (90)
NAADP induces pH changes in the lumen of acidic Ca2+ stores. (2007) (87)
Ca2+ release induced by cyclic ADP-ribose. (1994) (86)
Effects of photoreleased cADP-ribose on calcium transients and calcium sparks in myocytes isolated from guinea-pig and rat ventricle. (1999) (86)
TPC 2 Is a Novel NAADP-sensitive Ca 2 Release Channel , Operating as a Dual Sensor of Luminal pH and Ca 2 * (2010) (82)
TPC2 Proteins Mediate Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)- and Agonist-evoked Contractions of Smooth Muscle* (2010) (79)
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP (2010) (78)
7-Deaza-8-bromo-cyclic ADP-ribose, the First Membrane-permeant, Hydrolysis-resistant Cyclic ADP-ribose Antagonist* (1997) (78)
Human lymphocyte antigen CD38 catalyzes the production of cyclic ADP‐ribose (1993) (77)
Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+ (2014) (77)
Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells. (2008) (77)
Nitric oxide induces intracellular Ca2+ mobilization and increases secretion of incorporated 5‐hydroxytryptamine in rat pancreatic β‐cells (1995) (75)
TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2 (2014) (75)
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes. (2011) (74)
The NO Pathway Acts Late during the Fertilization Response in Sea Urchin Eggs* (2003) (74)
Actions of cADP-ribose and its antagonists on contraction in guinea pig isolated ventricular myocytes. Influence of temperature. (1997) (72)
NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells. (2011) (72)
Differential regulation of nicotinic acid-adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMP. (1998) (70)
Widespread Distribution of Binding Sites for the Novel Ca2+-mobilizing Messenger, Nicotinic Acid Adenine Dinucleotide Phosphate, in the Brain* (2000) (70)
Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels (2010) (67)
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. (2006) (67)
Solubilization of Receptors for the Novel Ca2+-mobilizing Messenger, Nicotinic Acid Adenine Dinucleotide Phosphate* (2002) (66)
Cyclic ADP Ribose as a Calcium-Mobilizing Messenger (2000) (66)
NAADP‐induced calcium release in sea urchin eggs (2000) (64)
Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites (2008) (64)
Acidic NAADP-sensitive Calcium Stores in the Endothelium (2010) (64)
A pivotal role for cADPR‐mediated Ca2+ signaling: regulation of endothelin‐induced contraction in peritubular smooth muscle cells (2002) (62)
Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes (2015) (62)
Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling* (2014) (62)
NAADP receptors. (2011) (60)
Modulation of Xenopus embryo mesoderm-specific gene expression and dorsoanterior patterning by receptors that activate the phosphatidylinositol cycle signal transduction pathway. (1996) (59)
Vasodilation by the Calcium-mobilizing Messenger Cyclic ADP-ribose* (2003) (59)
An Antagonist of cADP-ribose Inhibits Arrhythmogenic Oscillations of Intracellular Ca2+ In Heart Cells* (1999) (59)
Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP) (2005) (59)
Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. (2000) (58)
Cyclic ADP-ribose Enhances Coupling between Voltage-gated Ca2+ Entry and Intracellular Ca2+ Release* (1997) (58)
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart* (2015) (56)
NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata. (2009) (55)
High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart (2017) (54)
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells (2018) (54)
NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes. (2011) (53)
Two-pore Channels Form Homo- and Heterodimers*♦ (2011) (52)
Cyclic aristeromycin diphosphate ribose: A potent and poorly hydrolysable Ca2+‐mobilising mimic of cyclic adenosine diphosphate ribose (1996) (52)
Lysosome-Sarcoplasmic Reticulum Junctions A TRIGGER ZONE FOR CALCIUM SIGNALING BY NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE AND ENDOTHELIN-1* (2004) (50)
Prolonged Inactivation of Nicotinic Acid Adenine Dinucleotide Phosphate-induced Ca2+ Release Mediates a Spatiotemporal Ca2+ Memory* (2001) (47)
Analogues of the Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Antagonist Ned-19 Indicate Two Binding Sites on the NAADP Receptor* (2009) (45)
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells* (2015) (44)
Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor (2010) (44)
Diabetes mellitus as a predictor for radial artery vasoreactivity in patients undergoing coronary artery bypass grafting. (2007) (44)
Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase. (2002) (44)
Roles for adenosine ribose hydroxyl groups in cyclic adenosine 5'-diphosphate ribose-mediated Ca2+ release. (1997) (43)
Fertilization and Nicotinic Acid Adenine Dinucleotide Phosphate Induce pH Changes in Acidic Ca2+ Stores in Sea Urchin Eggs* (2007) (42)
Pharmacological characterization of the putative cADP-ribose receptor. (2001) (42)
Two neuropeptides recruit different messenger pathways to evoke Ca2+ signals in the same cell (2000) (42)
Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans (2014) (40)
An N‐Terminal Dileucine Motif Directs Two‐Pore Channels to the Tonoplast of Plant Cells (2012) (40)
Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart (2017) (40)
7-Deaza cyclic adenosine 5'-diphosphate ribose: first example of a Ca(2+)-mobilizing partial agonist related to cyclic adenosine 5'-diphosphate ribose. (1997) (39)
Endogenously Bound Calmodulin Is Essential for the Function of the Inositol 1,4,5-Trisphosphate Receptor* (2006) (39)
TPC: the NAADP discovery channel? (2015) (39)
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice (2021) (37)
Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling (2017) (37)
NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca2+ nanodomains, calcineurin and dynamin (2020) (37)
Imaging approaches to measuring lysosomal calcium. (2015) (36)
Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway (2016) (34)
A Cytosolic Sperm Protein Factor Mobilizes Ca2+ from Intracellular Stores by Activating Multiple Ca2+ Release Mechanisms Independently of Low Molecular Weight Messengers* (1997) (33)
Co-ordination of agonist-induced calcium signalling patterns by NAADP in pancreatic acinar cells (1999) (33)
Unveiling (−)‐Englerin A as a Modulator of L‐Type Calcium Channels (2016) (33)
Two-pore channels for integrative Ca2+ signaling (2010) (33)
A cADP-ribose antagonist does not inhibit secretagogue-, caffeine- and nitric oxide-induced Ca2+ responses in rat pancreatic beta-cells. (1995) (32)
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell (2010) (32)
Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. (2014) (32)
Investigating cADPR and NAADP in intact and broken cell preparations. (2008) (31)
NAADP Receptors. (2019) (31)
Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling (2018) (31)
Kinetic Properties of Nicotinic Acid Adenine Dinucleotide Phosphate-induced Ca2+ Release* (1997) (30)
β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart. (2012) (30)
Regenerative and non‐regenerative calcium transients in hamster eggs triggered by inositol 1,4,5‐trisphosphate. (1994) (29)
2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives. (2008) (29)
Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord (2020) (29)
ADP-ribose gates the fertilization channel in ascidian oocytes. (1998) (29)
The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction* (2010) (29)
Calmodulin Dissociation Mediates Desensitization of the cADPR-Induced Ca2+ Release Mechanism (2002) (28)
Dual effects of cyclic ADP-ribose on sarcoplasmic reticulum Ca2+ release and storage in cardiac myocytes isolated from guinea-pig and rat ventricle. (2007) (28)
Sperm express a Ca2+-regulated NAADP synthase. (2008) (27)
Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate (2007) (27)
AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells. (2006) (27)
Physiological roles of NAADP-mediated Ca2+ signaling (2011) (27)
Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca(2+) signaling during myogenesis in intact zebrafish. (2015) (26)
Chemoenzymatic synthesis of analogues of the second messenger candidate cyclic adenosine 5′-diphosphate ribose (1995) (24)
Nitric oxide gates fertilization channels in ascidian oocytes through nicotinamide nucleotide metabolism. (1997) (24)
Nitric oxide induces intracellular Ca2+ mobilization and increases secretion of incorporated 5-hydroxytryptamine in rat pancreatic beta-cells. (1995) (24)
‘Click cyclic ADP-ribose’: a neutral second messenger mimic (2014) (24)
Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues. (1999) (23)
Calcium store depletion potentiates a phosphodiesterase inhibitor‐ and dibutyryl cGMP‐evoked calcium influx in rat pituitary GH3 cells (1996) (22)
Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos. (2017) (22)
Microinjection of cyclic ADP-ribose triggers a regenerative wave of Ca2+ release and exocytosis of cortical alveoli in medaka eggs (1999) (21)
Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor† †This paper is part of an Organic & Biomolecular Chemistry web theme issue on chemical biology. (2010) (21)
The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion (2016) (21)
Mechanisms of calcium release and sequestration in eggs of Chaetopterus pergamentaceus. (1998) (21)
Hax‐1 identified as a two‐pore channel (TPC)‐binding protein (2013) (20)
SYNTHESIS OF 7-DEAZA-8-BROMO CYCLIC ADENOSINE 5'-DIPHOSPHATE RIBOSE: THE FIRST HYDROLYSIS RESISTANT ANTAGONIST AT THE CADPR RECEPTOR (1997) (20)
Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor. (2011) (19)
Differential effect of temperature on histamine‐ and carbachol‐stimulated inositol phospholipid breakdown in slices of guinea‐pig cerebral cortex (1987) (19)
Cyclic ADP-ribose and the regulation of calcium-induced calcium release in eggs and cardiac myocytes (2007) (19)
Methods in Cyclic ADP-Ribose and NAADP Research (2005) (19)
Pyridine nucleotide metabolites and calcium release from intracellular stores. (2012) (18)
Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. (2006) (18)
Two-Pore Channels: Lessons from Mutant Mouse Models. (2015) (18)
The relative order of IP3 sensitivity of types 1 and 3 IP3 receptors is pH dependent (1999) (17)
Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance (2019) (17)
Convergent synthesis and unexpected Ca(2+)-mobilizing activity of 8-substituted analogues of cyclic ADP-carbocyclic-ribose, a stable mimic of the Ca(2+)-mobilizing second messenger cyclic ADP-ribose. (2003) (16)
Inhibition of cADPR-Hydrolase by ADP-ribose potentiates cADPR synthesis from beta-NAD+. (1996) (15)
Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate. (2004) (15)
NAADP Receptors with Distinct Roles for Ca 2 + Signaling and Endolysosomal Trafficking (2010) (14)
NAADP receptors. (2005) (13)
A two-pore channel protein required for regulating mTORC1 activity on starvation (2020) (13)
A master protocol to investigate a novel therapy acetyl-l-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 gangliosidoses, and ataxia telangiectasia (2020) (13)
A multiscale analysis in CD38−/− mice unveils major prefrontal cortex dysfunctions (2019) (13)
Does lysosomal rupture evoke Ca2+ release? A question of pores and stores. (2019) (12)
Cyclic ADP-Ribose and Calcium Signalling (1998) (12)
Ionophore-Induced Calcium Waves Activate Unfertilized Zebrafish (Dank rerio) Eggs. (1996) (12)
Faculty Opinions recommendation of Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta. (2004) (12)
Pancreatic enzymes in chronic renal failure and transplant patients (1992) (11)
Clinical effectiveness of apheresis in the treatment of progressive systemic sclerosis. (1983) (10)
Synthesis of cyclic adenosine 5 ¢-diphosphate ribose analogues : a C 2 ¢ endo / syn “ southern ” ribose conformation underlies activity at the sea urchin cADPR receptor † (2010) (10)
Phospholipase C-dependent Ca2+ release by worm and mammal sperm factors. (2003) (10)
Ca2+ release induced by cyclic ADP ribose in mice lacking type 3 ryanodine receptor. (2001) (9)
TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons. (2018) (9)
Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells. (2015) (9)
Current methods to analyze lysosome morphology, positioning, motility and function (2022) (9)
Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores. (2019) (9)
Aplysia californica mediated cyclisation of novel 3'-modified NAD+ analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5'-diphosphate ribose. (2004) (9)
An emerging role for NAADP-mediated Ca 2 + signaling in the pancreatic beta-cell (2011) (9)
Mechanistic convergence and shared therapeutic targets in Niemann‐Pick disease (2019) (9)
Transmembrane signalling in insects (1990) (8)
Effects of N-Acetyl-Leucine and its enantiomers in Niemann-Pick disease type C cells (2019) (8)
Pharmacological modulation of oscillations in the blowfly salivary gland (1988) (8)
Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos. (2019) (8)
Chapter 23 – Cyclic ADP-Ribose and Calcium Signaling (1996) (8)
Cytolytic granules supply Ca2+ for their own exocytosis via NAADP and resident two-pore channels (2013) (8)
Acetylation turns leucine into a drug by membrane transporter switching (2021) (7)
Lithium‐induced decrease in spontaneous Ca2+ oscillations in single GH3 rat pituitary cells (1994) (7)
The luminal Ca2+ chelator, TPEN, inhibits NAADP-induced Ca2+ release (2012) (7)
Preparation and use of sea urchin egg homogenates. (2014) (7)
Regulation of Synthesis of cADPR and NAADP (2002) (7)
CHEMICAL SYNTHESIS OF THE NOVEL CA2+ MESSENGER NAADP (2005) (6)
The NAADP receptor: commentary on Billington et al. (2004) (6)
NAADP-Induced Ca 2+ Release: Two-Pore or Not Two-Pore? (2013) (6)
ADP-ribose gates the fertilization channel in ascidian oocytes. (1998) (6)
RESEARCH COMMUNICATION Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca 2 + from a thapsigargin-insensitive pool (1996) (6)
Choreographing endo-lysosomal Ca2+ throughout the life of a phagosome. (2021) (6)
Acidic Ca2+ stores and immune-cell function. (2021) (6)
The Role of Calcium and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Human Osteoclast Formation and Resorption (2014) (5)
Rifampicin reduces nephrotoxicity of cyclosporine A in rats: studies of renal enzyme excretion. (1988) (5)
Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+). (2007) (5)
Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²⁺ release. (2014) (4)
Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals (2020) (4)
Sensitizing Calcium-Induced Calcium Release (2002) (4)
Luminal Ca2+ is a Major Sensitiser of Two-Pore Channels to NAADP (2010) (4)
Essential role of NAADP-evoked calcium release in glucose-mediated depolarization, [Ca2+]i spiking and insulin secretion in mouse pancreatic beta cell (2009) (4)
factor in human endothelial cells NAADP links histamine H1 receptors to secretion of von Willebrand (2012) (3)
The Role of NAADP-Mediated Endo-Lysosomal Calcium Release in the Cardiac Atria (2020) (3)
Revealing the secrets of secretion (2018) (3)
Psammechinus miliaris egg homogenate as a model to investigate Ca2+-release mechanisms (1999) (3)
A Special Issue on Third and Fourth NAD (ASIAN 3) Meetings in 2014 (2014) (3)
The ecto-enzyme CD 38 is a NAADP synthase which couples receptor activation to Ca 2 + mobilization from lysosomes in pancreatic acinar cells (2010) (3)
Lysosomal agents inhibit store-operated Ca2+ entry (2020) (3)
Synthesis of NAADP-AM as a membrane-permeant NAADP analog. (2014) (3)
Nicotinic acid adenine dinucleotide phosphate evokes global calcium signals in mouse pulmonary arterial smooth muscle cells by activating Two Pore Segment Channel 2 (2011) (2)
Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg. (2001) (2)
Spatial and Temporal Control of Calcium Signaling by NAADP (2002) (2)
TPC2 is a Novel NAADP-Sensitive Intracellular Ca2+-Release Channel with Unique Gating Characteristics (2011) (2)
Requirement of calmodulin for actions of cADPR in guinea-pig ventricular myocytes (2002) (2)
A tribute to Professor Sir Michael J. Berridge FRS (1938-2020). (2021) (2)
Carvedilol inhibits cADPR- and IP3-induced Ca2+ release. (2016) (2)
Prolonged Inactivation of Nicotinic Acid Adenine Dinucleotide Phosphate-induced Ca 21 Release Mediates a Spatiotemporal (2001) (2)
NAADP-Mediated Ca2+ Signalling. (2022) (2)
[Comparative study of the elimination of several specific renal enzymes in rats after oral treatment with cyclosporin A administered in 2 vehicles of different nature]. (1987) (1)
[The action of cyclosporin A (CSA) on glycogen synthesis processes in rats in vivo]. (1989) (1)
CHAPTER 38 – Calcium Signaling (2001) (1)
CHAPTER 124 – Cyclic ADP-ribose and NAADP (2003) (1)
Does nicotinic acid adenine dinucleotide phosphate elicit Ca 2+ release via two-pore channel subtype 2 in rat arterial smooth muscle cells? (2008) (1)
Reply to “TPC1 Knockout Knocks Out TPC1” (2015) (1)
Professor Sir Michael Berridge FRS (1938–2020) (2020) (1)
Lysosomal agents inhibit store-operated Ca2+ entry. (2021) (1)
Intracellular CD38 Mediates Cardiac Synthesis of NAADP and CADPR (2016) (1)
Two-pore channels: going with the flows (2022) (1)
INHIBITION OF EXCITATION-CONTRACTION COUPLING IN GUINEA-PIG ISOLATED VENTRICULAR MYOCYTES BY AN ANTAGONIST OF CYCLIC ADP-RIBOSE (1995) (1)
Interfering with lysosomal function in atrial and ventricular myocytes reduces the response to isoprenaline (2012) (1)
Acetylation of L-leucine switches its carrier from the L-amino acid transporter (LAT) to organic anion transporters (OAT) (2020) (1)
Synthesis of 7-Deaza-8-bromo Cyclic Adenosine 5′-Diphosphate Ribose ( VI): The First Hydrolysis Resistant Antagonist at the cADPR Receptor. (1997) (1)
Author response: Intracellular sphingosine releases calcium from lysosomes (2015) (1)
Lysosomes and Ryanodine receptors co-localise to form a 'trigger zone' for Ca 2+ signalling by NAADP in isolated rat pulmonary artery smooth muscle cells (2004) (1)
Glybenclamide and cyclosporine A: an interaction on glucose metabolism. (1988) (1)
A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue (2021) (1)
Defective platelet function in Niemann‐Pick disease type C1 (2020) (1)
Synthesis, degradation, binding and actions of NAADP in cardiac tissue. (2001) (1)
Characterization of mouse two-pore channels (TPCs) in NAADP-mediated Ca(2+) signalling (2011) (1)
Mechanically Induced Calcium Release From Xenopus Cell Cycle Extracts. (1993) (1)
Role of the Putative NAADP Receptor, Two-Pore Channel 2, in Ventricular Myocyte Responses to Isoproterenol (2010) (1)
CAPD + Hemoperfusion Once a Week for End Stage Renal Disease (1982) (1)
NAADP triggers 'Ca 2+ bursts' by mobilising lysosome-related calcium stores in isolated rat pulmonary artery smooth muscle cells (2003) (1)
The Involvement of NAADP and Two-Pore Ca2+ Channels in the Cardiac Beta-Adrenergic Response (2013) (1)
NAADP-mediated calcium signalling: molecular mechanisms and physiological roles (2015) (1)
Oxytocin Controls Male Sexual Activity via Non-Synaptic Axonal Release in the Spinal Cord (2020) (0)
Faculty Opinions recommendation of Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes. (2010) (0)
Effects of NAADP on contraction and calcium transients in guinea-pig isolated ventricular myocytes (2005) (0)
Lysosomal calcium loading promotes arrhythmias by potentiating ryanodine receptor release (2022) (0)
Recombinant human TPC2 and TPC1 are both NAADP-regulated ion channels but display important functional differences (2015) (0)
Faculty Opinions recommendation of Extracellular application of nicotinic acid adenine dinucleotide phosphate induces Ca2+ signaling in astrocytes in situ. (2005) (0)
Faculty Opinions recommendation of CD38 is critical for social behaviour by regulating oxytocin secretion. (2007) (0)
Vasodilation by the calcium-mobilizing messenger cyclic ADP-ribose. VOLUME 278 (2003) PAGES 9602-9608 (2006) (0)
A novel signalling role for NAADP in arterial smooth muscle (2013) (0)
Synthesis of [³²P]NAADP for the radioreceptor binding assay. (2014) (0)
The role of two pore channels (TPCs) in pancreatic beta cell stimulus-secretion coupling (2012) (0)
Characterisation of the human two-pore channels (2011) (0)
3245-Plat Calcium-Dependent Gating in MthK K D Channels Occurs at the Selectivity Filter (2014) (0)
Effect of cyclic ADP-ribose on calcium transients and contractions in guinea-pig ventricular myocytes without an increase in the loading of the sarcoplasmic reticulum with calcium (2004) (0)
Faculty Opinions recommendation of Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. (2018) (0)
Cardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins (2021) (0)
Faculty Opinions recommendation of NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system. (2018) (0)
Erratum: Vasodilation by the calcium-mobilizing messenger cyclic ADP-ribose (Journal of Biological Chemistry (2003) 278, (9602-9608)) (2006) (0)
Cell Signalling (2005) (0)
Faculty Opinions recommendation of Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytes. (2005) (0)
Faculty Opinions recommendation of Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. (2008) (0)
Role of NAADP in Coordinating Spatiotemporal Aspects of Calcium Signalling (2003) (0)
The efficiency of Grignard Pure™ to inactivate airborne SARS-CoV-2 surrogate (2022) (0)
Decision letter: Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function (2020) (0)
Faculty Opinions recommendation of Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes. (2003) (0)
NAADP: a novel Ca2+ mobilizing messenger during beta-adrenoceptor stimulation in guinea-pig ventricular myocytes (2007) (0)
The functional roles of Ca2+ mobilizing pyridine nucleotides cADPR and NAADP in detrusor and taenia caceum (2007) (0)
Pharmacological characteristics of [P-32] cADPR binding to sea urchin egg homogenate (2000) (0)
[Comments on and our case histories of infectious complications in the postoperative period]. (1989) (0)
NAADP MEDIATES CALCIUM SIGNALS BY ENDOTHELIN-1 IN ISOLATED RAT PULMONARY ARTERY SMOOTH MUSCLE CELLS (2004) (0)
Two pore channels (TPC) are Ca2+-permeable, NAADP-activated ion-channels with marked sensitivity to luminal Ca2+ (2010) (0)
Faculty Opinions recommendation of Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth. (2005) (0)
Cyclosporine A + Glybenclamide. Effect on Glucose Metabolism: Preliminary Results (1989) (0)
Does NAADP-induced Ca2+ release contribute to glucose-induced (ca(2+))(i) changes in primary mouse pancreatic beta-cell? (2006) (0)
Faculty Opinions recommendation of CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells. (2009) (0)
Faculty Opinions recommendation of Role of NAADP for calcium signaling in the salivary gland. (2019) (0)
CaMKII-Mediated Amplification is Essential to NAADP Signalling in Cardiac Myocytes (2014) (0)
Calcium stimulates the synthesis of nicotinic acid adenine dinucleotide phosphate (NAADP) in sea urchin sperm (2005) (0)
Equilibrium Ion Selectivity of Human TPC2 Studied using a Plasma Membrane-Targeted Human TPC2 and Spermine Block (2015) (0)
Identification and localisation of novel ADP-ribosyl cyclases in sea urchin eggs (2006) (0)
Unveiling (-)-Englerin A as a L-type calcium channel modulator (2016) (0)
Possible regulation of cardiac ADP-ribosyl cyclase by cGMP-dependent mechanisms (2000) (0)
Intracellular Calcium Channels: cADPR-Modulated (Ryanodine Receptors) (2004) (0)
NAADP and cADPR signalling in sea urchin eggs (2005) (0)
Synthesis of cADPR and NAADP by intracellular CD38 in heart: role in inotropic and arrhythmogenic effects of beta-adrenoceptor signaling (2016) (0)
cADPR and NAADP: messengers for calcium signalling (2007) (0)
Faculty Opinions recommendation of Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds. (2012) (0)
Degradation of the novel calcium mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, is calcium-dependent. (2001) (0)
Synthesis of caged NAADP. (2014) (0)
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion (2023) (0)
Adrenaline stimulates glucagon secretion in mouse alpha cells by provoking store-operated Ca2+ release (2016) (0)
Oestradiol rapidly regulates calcium signals in ciliary neurons from the chick embryo (2004) (0)
Rapid, selective and dose-dependent elevation of the second messenger NAADP (2005) (0)
Faculty Opinions recommendation of Local cytosolic Ca2+ elevations are required for stromal interaction molecule 1 (STIM1) de-oligomerization and termination of store-operated Ca2+ entry. (2011) (0)
Differential distribution of the enzyme activities for the synthesis and metabolism of cyclic ADP-ribose in rabbit pulmonary versus systemic artery smooth muscle: a novel redox sensing pathway? (2000) (0)
Open Nicotinic acid adenine dinucleotide phosphate (NAADP) and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic cells (2022) (0)
NAADP and two-pore channels are important for the contraction of airway smooth muscle cells (2010) (0)
A pivotal role for NAADP in histamine H1 receptor-induced calcium signaling (2009) (0)
Explorer TPCs : Endolysosomal channels for Ca 2 + mobilization from acidic organelles triggered by NAADP (2017) (0)
Sarcoplasmic reticulum Ca2+ release, cyclic ADP-ribose and hypoxic pulmonary vasoconstriction in rabbit pulmonary arteries: do O-2-sensing K+ channels play a supporting role? (2000) (0)
P124NAADP as a novel downstream mediator of cardiac beta-adrenergic pathway. (2014) (0)
Efficacy of Grignard Pure to Inactivate Airborne Phage MS2, a Common SARS-CoV-2 Surrogate (2023) (0)
Faculty Opinions recommendation of Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. (2020) (0)
Phospholipase C-dependent calcium release in Chaetopterus egg microsomes in response to mammalian sperm factor (2002) (0)
Development of Inositol-Based Antagonists for the D-myo-Inositol 1,4,5-Triphosphate Receptor. (2011) (0)
Cyclic ADP-Ribose Activates Ryanodine Receptors While NAADP Activates Two Pore Channels (2010) (0)
- Cellular Signalling C 43 HYPOXIC PULMONARY VASOCONSTRICTION : IS AMP-ACTIVATED PROTEIN KINASE THE PRIMARY METABOLIC SENSOR AND EFFECTOR ? (2005) (0)
[Adsorbents in the treatment of uremia. Hemoperfusion plus hemodialysis]. (1979) (0)
Ip3 and the new wave in Ca2+ signalling (1993) (0)
Preface. Endolysosomal calcium signalling. (2023) (0)
[The first 48 hours of life of a child born to a mother undergoing hemodialysis treatment]. (1987) (0)
NAADP AS A NOVEL DOWNSTREAM MEDIATOR OF CARDIAC BETA-ADRENERGIC PATHWAY (2014) (0)
Two-pore Channels for Calcium Mobilization from Acidic Organelles and Cell Signaling by NAADP (2009) (0)
Response : Cyclic ADP-Ribose in β Cells (1993) (0)
Endosomal Pathway Role of TRP Channels in the Regulation of the (2011) (0)
IS038 CYCLIC ADP-RIBOSE AND CALCIUM SIGNALLING IN CARDIAC MYOCYTES (1997) (0)
Regulation and pathway of NAADP synthesis in sea urchin sperm (2006) (0)
[Surgery on the chronic dialysed uremia patient. Our case histories]. (1989) (0)
Faculty Opinions recommendation of Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells. (2004) (0)
A cellular protection racket: How lysosomal Ca2+ fluxes prevent kidney injury. (2020) (0)
Faculty Opinions recommendation of Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating. (2013) (0)
Membrane Transport | Cyclic ADP-RIBOSE and NAADP: Two Pyridine Nucleotide Ca2+ Mobilizing Messengers Targeting Intracellular Ca2+ Release Channels (2021) (0)
Obituary: Michael Berridge 1938 – 2020 (2020) (0)
Nicotinic acid adenine dinucleotidephosphate degradation in mammalian tissue (2000) (0)
A two-pore channel protein required for regulating mTORC1 activity on starvation (2020) (0)
Release of acidic store calcium is required for effective priming of the NLRP3 inflammasome (2022) (0)
Faculty Opinions recommendation of Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. (2020) (0)
[Kidney transplants in Sicily. Our experience with surgery and CyA immunosuppression]. (1989) (0)
Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation (2023) (0)
34P Oral Communication-Cellular Signalling C43 HYPOXIC PULMONARY VASOCONSTRICTION: IS AMP- ACTIVATED PROTEIN KINASE THE PRIMARY METABOLIC SENSOR AND EFFECTOR? (2005) (0)
Cellular Signalling C133‐C151, PC47‐PC70 (2004) (0)
TPC1 is a Proton Permeable Channel that can be Independently Activated by Cytosolic Calcium or NAADP (2014) (0)
Cyclic ADP-ribose and NAADP (2010) (0)
Actions of cADP-ribose phosphate on contraction in guinea-pig isolated ventricular myocytes (2002) (0)
Faculty Opinions recommendation of Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release. (0)
CD38 antigen, a key player in NAADP production and CCK responses in pancreatic exocrine cells (2006) (0)
Sperm expresses a surface bound base exchange enzyme that selectively synthesises NAADP and is controlled by calcium. (2006) (0)
Measurement of luminal pH of acidic stores as a readout for NAADP action. (2014) (0)
Sperm expresses surface bound base exchange enzyme that selectively synthesises NAADP (2005) (0)
Faculty Opinions recommendation of Two intracellular pathways mediate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons. (2003) (0)
Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats. (1999) (0)
Actions of a membrane permeant analogue of NAADP on contractions and calcium sparks in cardiac ventricular myocytes. (2007) (0)
Erratum: Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, (19927-19932) DOI: 10.1073/pnas.1007381107) (2011) (0)
Enzymatic Synthesis and Biological Evaluation of Photolabile Nictonic Acid Adenine Dinuclotide Phosopate (NAADP) (2013) (0)
The Role of Calcium and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Human Osteoclast Formation and Resorption (2014) (0)

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