Ardem Patapoutian
#9,468
Most Influential Person Now
Molecular biologist, neuroscientist, and Nobel laureate 2021
Ardem Patapoutian's AcademicInfluence.com Rankings
Ardem Patapoutianbiology Degrees
Biology
#478
World Rank
#844
Historical Rank
#282
USA Rank
Neuroscience
#186
World Rank
#197
Historical Rank
#79
USA Rank
Molecular Biology
#759
World Rank
#776
Historical Rank
#176
USA Rank
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Biology
Ardem Patapoutian's Degrees
- PhD Molecular Biology University of California, San Francisco
Why Is Ardem Patapoutian Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ardem Patapoutian is an Lebanese-American molecular biologist, neuroscientist, and Nobel Prize laureate of Armenian descent. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian is a neuroscience professor and Howard Hughes Medical Institute investigator at Scripps Research in La Jolla, California. In 2021, he won the Nobel Prize in Physiology or Medicine jointly with David Julius.
Ardem Patapoutian's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures (2003) (2279)
- A TRP Channel that Senses Cold Stimuli and Menthol (2002) (1979)
- Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels (2010) (1783)
- Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin (2004) (1681)
- Large-scale analysis of the human and mouse transcriptomes (2002) (1576)
- Trk receptors: mediators of neurotrophin action (2001) (1085)
- Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines (2007) (1008)
- Nociceptors: the sensors of the pain pathway. (2010) (880)
- A Heat-Sensitive TRP Channel Expressed in Keratinocytes (2002) (856)
- TRPM8 Is Required for Cold Sensation in Mice (2007) (780)
- ThermoTRP channels and beyond: mechanisms of temperature sensation (2003) (750)
- Trp ion channels and temperature sensation. (2006) (713)
- Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin (2005) (698)
- Piezo2 is the major transducer of mechanical forces for touch sensation in mice (2014) (579)
- The Pungency of Garlic: Activation of TRPA1 and TRPV1 in Response to Allicin (2005) (568)
- Transient receptor potential channels: targeting pain at the source (2009) (563)
- Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014) (551)
- Piezo2 is required for Merkel cell mechanotransduction (2014) (522)
- Piezos are pore-forming subunits of mechanically activated channels (2011) (463)
- SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel (2014) (422)
- Epidermal Merkel Cells are Mechanosensory Cells that Tune Mammalian Touch Receptors (2014) (405)
- A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition (2007) (401)
- The role of Drosophila Piezo in mechanical nociception (2011) (395)
- More than cool: Promiscuous relationships of menthol and other sensory compounds (2006) (378)
- Piezo2 is the principal mechanotransduction channel for proprioception (2015) (365)
- Piezo1 links mechanical forces to red blood cell volume (2015) (354)
- Chemical activation of the mechanotransduction channel Piezo1 (2015) (348)
- The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily (1990) (346)
- Structure of the mechanically activated ion channel Piezo1 (2017) (319)
- Roles of Wnt proteins in neural development and maintenance (2000) (306)
- The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. (2005) (305)
- Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections (2008) (284)
- An Ion Channel Essential for Sensing Chemical Damage (2007) (282)
- Piezo1 Channels Are Inherently Mechanosensitive. (2016) (280)
- Piezos thrive under pressure: mechanically activated ion channels in health and disease (2017) (266)
- Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels (2008) (263)
- TRPA1 Contributes to Cold Hypersensitivity (2010) (259)
- Ion channels: Opposite thermosensor in fruitfly and mouse (2003) (251)
- Piezo2 senses airway stretch and mediates lung inflation-induced apnoea (2016) (248)
- Mechanically Activated Ion Channels (2015) (246)
- Dehydrated Hereditary Stomatocytosislinked to gain-of-function mutations in mechanically activated PIEZO1 ion channels (2013) (234)
- PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex (2018) (232)
- TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP (2009) (225)
- Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. (1995) (224)
- High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol (2006) (222)
- Caenorhabditis elegans TRPA-1 functions in mechanosensation (2007) (215)
- TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice (2009) (212)
- Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia (2015) (207)
- Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane (2009) (198)
- Zinc activates damage-sensing TRPA1 ion channels. (2009) (198)
- Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia Direct NT-3 Activation of TrkB Neurons In Vivo (1998) (198)
- LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength (2016) (196)
- A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. (2006) (194)
- TRPV1 Is Activated by Both Acidic and Basic pH (2009) (189)
- Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis (2013) (187)
- The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice (2018) (184)
- Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain (2010) (180)
- From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs (2007) (172)
- GPR68 Senses Flow and Is Essential for Vascular Physiology (2018) (166)
- Evidence for Developmentally Programmed Transdifferentiation in Mouse Esophageal Muscle (1995) (165)
- Discoveries in structure and physiology of mechanically activated ion channels (2020) (162)
- Piezo1 ion channel pore properties are dictated by C-terminal region (2015) (160)
- OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels (2018) (157)
- Correction: Corrigendum: Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels (2013) (155)
- Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation (2018) (155)
- Pore region of TRPV3 ion channel is specifically required for heat activation (2008) (152)
- Inflammatory signals enhance piezo2-mediated mechanosensitive currents. (2012) (143)
- Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection (2018) (137)
- Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression (2011) (122)
- TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. (2011) (114)
- Merkel cells and neurons keep in touch. (2015) (111)
- Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4 (2009) (109)
- Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice. (1993) (102)
- Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six (2014) (93)
- Mechanosensory hair cells express two molecularly distinct mechanotransduction channels (2016) (92)
- The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration (2019) (89)
- Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization (2017) (88)
- Crystal structure of the human TRPV2 channel ankyrin repeat domain (2006) (83)
- The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors (2015) (82)
- Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate (2004) (80)
- Structure of the human volume regulated anion channel (2018) (80)
- Cryo-EM structure of the mechanically activated ion channel OSCA1.2 (2018) (74)
- PIEZO2 in sensory neurons and urothelial cells coordinates urination (2020) (71)
- Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors. (1999) (71)
- Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses (2018) (57)
- TRP channels and thermosensation. (2005) (56)
- Identification and purification of a factor that binds to the Mlu I cell cycle box of yeast DNA replication genes. (1991) (55)
- A role of PIEZO1 in iron metabolism in mice and humans (2021) (54)
- Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations (2013) (49)
- PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana (2020) (41)
- Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels (2009) (36)
- Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype (2011) (36)
- Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. (2014) (35)
- Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing (2020) (35)
- Scratching the surface: a role of pain-sensing TRPA1 in itch (2011) (33)
- Mechanically Activated Ion Channels (2015) (32)
- Large-scale analysis of the human and mouse (2002) (28)
- Stretch-activated ion channels identified in the touch-sensitive structures of carnivorous Droseraceae plants (2020) (24)
- Faculty Opinions recommendation of Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. (2004) (24)
- Heterozygous variants in the mechanosensitive ion channel TMEM63A result in transient hypomyelination during infancy (2019) (24)
- Why Does Morphine Make You Itch? (2011) (23)
- PIEZO1 transduces mechanical itch in mice (2022) (21)
- The role of somatosensory innervation of adipose tissues (2022) (12)
- Itching for Insight (2009) (10)
- Channeling pain (2006) (9)
- Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection (2017) (8)
- Making the Pain Connection (2001) (7)
- Author response: Chemical activation of the mechanotransduction channel Piezo1 (2015) (6)
- The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance (2022) (6)
- Discoveries of receptors for temperature and touch (2021) (5)
- Channels: flies feel your pain. (2010) (4)
- Editorial Note to: Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization (2017) (4)
- Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice (2020) (4)
- Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis (2022) (4)
- Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1 (2021) (4)
- Faculty Opinions recommendation of TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. (2004) (3)
- PIEZO1-induced cellular retraction controls keratinocyte migration in wound healing (2020) (3)
- A hot new channel (2012) (3)
- Erratum to "Mechanically Activated Ion Channels" [Neuron 87, 1162-1179, September 23, 2015] (2015) (2)
- Neuroscience: Salty sensations (2013) (2)
- Structure of mechanically activated ion channel OSCA1.2 in LMNG (2018) (2)
- Getting a grip on touch receptors (2020) (2)
- Airway mechanoreceptors that control breathing (2018) (1)
- Reevaluation of Piezo1 as a gut RNA sensor (2022) (1)
- Single-Point Mutations in Ankyrin Repeat Six Make Mouse TRPA1 Sensitive to Hot Temperatures (2014) (1)
- ABSTRACTS OF PAPERS AT THE SIXTY-EIGHTH ANNUAL MEETING OF THE SOCIETY OF GENERAL PHYSIOLOGISTS: Sensory Transduction (2014) (1)
- Outer Pore Domain of TRPV1 Ion Channel is Required for Temperature-Independent Step During Temperature-Activation (2010) (0)
- Role of Piezo Ion Channels in Mechanosensation (2017) (0)
- OSCA / TMEM 63 are an Evolutionarily Conserved Family of Mechanically Activated Ion 1 Channels 2 (0)
- Symposium 13: Epigenetic Control of Gene (2010) (0)
- Nicotinic Acetylcholine Receptor Subtypes Dorsal Root Ganglion Neurons Express Multiple (2015) (0)
- May the Force Be with You: Search for Ion Channels that Respond to Pressure (2014) (0)
- Introduction to the Journal of Neurobiology special issue on nociception (2004) (0)
- Abstract 374: Gpr68 Senses Blood Flow and is Essential for Vascular Physiology (2018) (0)
- Correction: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing (2022) (0)
- Author Correction: Structure of the mechanically activated ion channel Piezo1 (2022) (0)
- Spinothalamic Neurons in the Cat Nociceptive Lamina I Trigeminothalamic and Differential Projections of Thermoreceptive and (2015) (0)
- Structure of human Volume Regulated Anion Channel composed of SWELL1 (LRRC8A) (2018) (0)
- Eicosapentaenoic acid enhances PIEZO2 inactivation and counteracts PIEZO2 gain of function mutations. (2023) (0)
- Author response: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing (2021) (0)
- Noxious Inflammation Neural damage and ectopic firing Nociceptive pain Inflammatory pain (0)
- Direct observation of Piezo1 conformational states. (2023) (0)
- Lighting Up Mechanosensation: dyeing to see PIEZO2 (2022) (0)
- How do you feel? The molecules that sense touch. (2023) (0)
- Probing Mechanisms of Temperature Sensitivity of Thermo-TRPs (2010) (0)
- Inhibition of Action Potentials in Rat Trigeminal Ganglion Intracellular Acidification Is Associated with Changes in Free Cytosolic Calcium and (2015) (0)
- Neuroscience: Precision memories (2009) (0)
- Platform Z: Mechanosensitive & TRP Channels (2010) (0)
- Author Correction: Structure of the mechanically activated ion channel Piezo1 (2022) (0)
- PIEZO2 in somatosensory neurons controls gastrointestinal transit (2022) (0)
- TRPV 3 Regulates NOS-Independent Nitric Oxide Synthesis in the Skin (2012) (0)
- Structure of mechanically activated ion channel OSCA1.2 in nanodisc (2018) (0)
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