Arie Lev Gruzman
Israeli chemist
Arie Lev Gruzman's AcademicInfluence.com Rankings

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Chemistry
Arie Lev Gruzman's Degrees
- Bachelors Chemistry Tel Aviv University
- Masters Chemistry Technion – Israel Institute of Technology
- PhD Chemistry Weizmann Institute of Science
Why Is Arie Lev Gruzman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Arie Lev Gruzman is a professor of chemistry at Bar Ilan University specializing in Medicinal Chemistry. Biography Arie Lev Gruzman was born in Gorky , Russia. He graduated from as a practical nurse. At the same year, he enrolled at the Pediatric faculty of Gorky Academy for Medicine . After two and a half years, he interrupted his education towards M.D. and repatriated to Israel in 1991. He obtained his B.Sc. in Medicinal chemistry from Bar-Ilan University and a Ph.D. from the School of Pharmacy, Faculty of Medicine, at the Hebrew University of Jerusalem under the supervision of Prof. Shlomo Sasson and Prof. Jehoshua Katzehendler. After a military service in the IDF, he was a postdoctoral researcher at the Department of Physiology, University of California, San Francisco School of Medicine and at California Pacific Medical Center at San Francisco, under the supervision of Prof. Vishvanath Lingappa. After returning to Israel, he worked as a head of a project at Yissum Research Development Company of the Hebrew University. Since 2009 he is a faculty member in the department of chemistry at Bar-Ilan University. Gruzman served as a vice-president of the Medicinal Chemistry Section of the Israel Chemical Society MCS-ICS . He is also one of the founders of the startup drug development company “AltA-ZuZ”.
Arie Lev Gruzman's Published Works
Published Works
- Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis (2007) (194)
- Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations. (2009) (109)
- Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction* (2016) (69)
- The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes (2007) (67)
- The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells (2010) (65)
- A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid. (2002) (61)
- Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. (2013) (61)
- Delayed autoregulation of glucose transport in vascular endothelial cells (2005) (48)
- Synthesis and characterization of new and potent α-lipoic acid derivatives (2004) (44)
- Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor. (2003) (38)
- A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2 (2015) (37)
- Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha. (2008) (34)
- Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation (2013) (26)
- Erratum to: Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations by Gruzman et al., Rev Diabet Stud 2009, 6(1):13-36. (2009) (26)
- 4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells. (2004) (25)
- Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells. (2002) (24)
- Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements. (2001) (24)
- Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch (2020) (19)
- Direct production of glucose from glycogen under microwave irradiation (2012) (17)
- A Chemical Chaperone‐Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS) (2015) (17)
- Activation of PPARδ: from computer modelling to biological effects (2015) (16)
- Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress. (2013) (15)
- Novel inhibitors of leukocyte transendothelial migration. (2019) (15)
- Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation. (2014) (15)
- Pruritus in psoriasis and atopic dermatitis: current treatments and new perspectives (2021) (13)
- Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKα-independent manner (2006) (12)
- Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage (2019) (11)
- Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cδ-dependent manner (2007) (11)
- Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose. (2017) (11)
- Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site (2020) (10)
- Investigation of the Membrane Fluidity Regulation of Fatty Acid Intracellular Distribution by Fluorescence Lifetime Imaging of Novel Polarity Sensitive Fluorescent Derivatives (2021) (10)
- Synthesis and characterization of new and potent alpha-lipoic acid derivatives. (2004) (10)
- SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex (2015) (10)
- Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy. (2017) (9)
- A versatile water-soluble chelating and radical scavenging platform. (2016) (9)
- The lipophilic 4-phenylbutyric acid derivative prevents aggregation and retention of misfolded proteins. (2019) (9)
- An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. (2018) (9)
- Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. (2021) (8)
- Antihyperglycaemic activity of 2,4:3,5-dibenzylidene-D-xylose-diethyl dithioacetal in diabetic mice (2012) (8)
- A New Oxopiperazin‐Based Peptidomimetic Molecule Inhibits Prostatic Acid Phosphatase Secretion and Induces Prostate Cancer Cell Apoptosis (2016) (7)
- Activators of AMPK: not just for type II diabetes. (2014) (7)
- Antiproliferative Effect of Novel Aminoacridine-based Compounds. (2015) (7)
- A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK (2017) (6)
- Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics (2019) (6)
- Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model. (2018) (6)
- One‐pot three‐component preparation of novel selenium‐containing spiroketals (2013) (6)
- Design and synthesis of novel protein kinase R (PKR) inhibitors (2016) (6)
- Glucose Transport Regulators (2005) (6)
- Gene silencing by siRNA nanoparticles synthesized via sonochemical method (2014) (6)
- NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis (2022) (6)
- Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. (2007) (6)
- Chemical chaperones targeted to the endoplasmic reticulum (ER) and lysosome prevented neurodegeneration in a C9orf72 repeat expansion drosophila amyotrophic lateral sclerosis (ALS) model (2021) (5)
- Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose (2017) (5)
- Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer. (2018) (5)
- Carbonic Anhydrase I Is Recognized by an SOD1 Antibody upon Biotinylation of Human Spinal Cord Extracts (2010) (5)
- SH-29 and SK-119 Attenuates Air-Pollution Induced Damage by Activating Nrf2 in HaCaT Cells (2021) (4)
- A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice (2021) (3)
- Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis (2021) (2)
- Multifunctionality of Prostatic Acid Phosphatase in Prostate Cancer Pathogenesis. (2021) (2)
- Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions. (2018) (2)
- Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer. (2018) (2)
- 4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice (2022) (1)
- Peptide-based development of PKA activators (2018) (1)
- Hydrogel nanoparticles covered by neuroligin-2-derived peptide-protected β cells under oxidative stress and increase their proliferation (2018) (1)
- Sonochemically-induced spectral shift as a probe of green fluorescent protein release from nano capsules (2014) (1)
- Development and characterisation of SMURF2-targeting modifiers (2021) (1)
- Development of anti-inflammatory peptidomimetics based on the structure of human alpha1-antitrypsin. (2021) (1)
- Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur (2020) (1)
- Front Cover: Computer‐Aided Design and Synthesis of 1‐{4‐[(3,4‐Dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic Acid as an Nrf2 Enhancer (ChemPlusChem 5/2018) (2018) (0)
- Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. (2020) (0)
- A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK (2017) (0)
- Novel pentosederivater as antihyperglycaemic agents (2003) (0)
- 552 Pharmacological activation of the Nrf2 pathway attenuates UVB & LPS-induced damage (2019) (0)
- Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model (2019) (0)
- Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators (2023) (0)
- Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-β) modulator (2021) (0)
- Design and synthesis of novel protein kinase R (PKR) inhibitors (2016) (0)
- SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex (2015) (0)
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