Arlan G. Richardson

Arlan G. Richardson's AcademicInfluence.com Rankings

Arlan G. Richardson

Social Work

#70

World Rank

#80

Historical Rank

Gerontology

#33

World Rank

#35

Historical Rank

social-work Degrees

Arlan G. Richardson

Biology

#11635

World Rank

#15044

Historical Rank

Biochemistry

#1939

World Rank

#2080

Historical Rank

biology Degrees

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Social Work
Biology

Arlan G. Richardson's Degrees

PhD Biochemistry University of Texas at Austin

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Arlan G. Richardson's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Geroscience: Linking Aging to Chronic Disease (2014) (1391)
Trends in oxidative aging theories. (2007) (1054)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease (2010) (865)
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. (2003) (731)
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. (2010) (650)
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. (2003) (613)
The role of oxidative damage and stress in aging (2004) (596)
Is the oxidative stress theory of aging dead? (2009) (562)
Methionine oxidation and aging. (2005) (368)
Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits (2011) (344)
The overexpression of major antioxidant enzymes does not extend the lifespan of mice (2008) (325)
Expression of heat shock protein 70 is altered by age and diet at the level of transcription (1993) (322)
Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. (2007) (303)
Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration (2010) (253)
Rapamycin extends life and health in C57BL/6 mice. (2014) (240)
Oxidative damage to mitochondria and aging (2001) (234)
Genetic mouse models of extended lifespan (2003) (233)
Retardation of Atherosclerosis by Overexpression of Catalase or Both Cu/Zn-Superoxide Dismutase and Catalase in Mice Lacking Apolipoprotein E (2004) (228)
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer (2016) (225)
Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis* (2004) (215)
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. (2001) (212)
Effect of dietary restriction on the age-dependent changes in the expression of antioxidant enzymes in rat liver. (1990) (202)
A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA. (2001) (199)
Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction. (1995) (195)
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. (2009) (191)
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. (2007) (191)
Effect of age on the expression of antioxidant enzymes in male Fischer F344 rats (1990) (188)
Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling (2012) (184)
Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain. (2012) (168)
Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. (1999) (160)
Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease (2013) (157)
The role of DNA methylation in epigenetics of aging (2018) (147)
Detection of protein carbonyls in aging liver tissue: A fluorescence-based proteomic approach (2006) (144)
Caloric restriction mimetics: metabolic interventions. (2001) (144)
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau (2010) (143)
Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice (2008) (134)
Does Reduced IGF-1R Signaling in Igf1r +/− Mice Alter Aging? (2011) (134)
Age-related alterations in the activation of heat shock transcription factor 1 in rat hepatocytes. (2000) (130)
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span (2009) (129)
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats (2008) (126)
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. (2004) (123)
Short Form Glutathione Peroxidase 4 Is the Essential Isoform Required for Survival and Somatic Mitochondrial Functions* (2009) (118)
Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance (2011) (118)
A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence (2016) (117)
The expression of heat shock protein 70 decreases with cellular senescence in vitro and in cells derived from young and old human subjects. (1998) (113)
Caloric restriction and genomic stability (2007) (112)
Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. (2008) (112)
Expression of supreoxide dismutase and catalase in rat brain as a function of age (1991) (111)
The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis (2009) (109)
Lifespan extension in genetically modified mice (2009) (105)
Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress. (2008) (104)
Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease (2015) (104)
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. (2005) (103)
Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. (2003) (102)
How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story (2015) (102)
Gpx4 protects mitochondrial ATP generation against oxidative damage. (2007) (101)
The effect of aging and dietary restriction on DNA repair. (1989) (100)
Lipid peroxidation up‐regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer’s disease (2008) (94)
Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1. (1996) (91)
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity. (2009) (85)
The effect of age on the expression of Interleukin-2 (1996) (85)
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging (2011) (84)
Long-lived ames dwarf mice are resistant to chemical stressors. (2009) (83)
Expression of calbindin-D decreases with age in intestine and kidney. (1989) (82)
Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity (2006) (82)
Dietary restriction attenuates age‐associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD (2012) (81)
Current concepts: I. The relationship between age-related changes in gene expression, protein turnover, and the responsiveness of an organism to stimuli. (1982) (80)
PGC‐1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model (2011) (79)
Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. (2012) (79)
Role of mitochondrial superoxide dismutase in contraction-induced generation of reactive oxygen species in skeletal muscle extracellular space. (2004) (79)
Catalase transgenic mice: characterization and sensitivity to oxidative stress. (2004) (78)
The effect of aging on the expression of interleukin 2 messenger ribonucleic acid. (1986) (77)
Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes: effect of age and dietary restriction. (1998) (77)
Effect of age and dietary restriction on the expression of alpha 2u-globulin. (1987) (76)
Hsp70 and aging (1994) (76)
Housing density does not influence the longevity effect of calorie restriction. (2005) (76)
Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice (2014) (75)
Plasma protein biomarkers of the geriatric syndrome of frailty. (2014) (75)
Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation. (2011) (74)
Effect of age on liver protein synthesis and degradation (1991) (74)
Oxidative Damage to DNA and Aging (2003) (74)
Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta (2001) (73)
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. (2006) (72)
A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse (2017) (72)
Program for testing biological interventions to promote healthy aging (2000) (72)
The effect of age on the synthesis of two heat shock proteins in the hsp70 family. (1993) (72)
Effect of rapamycin on aging and age-related diseases—past and future (2020) (71)
Measures of Healthspan as Indices of Aging in Mice-A Recommendation. (2016) (71)
Effect of age on the function of mitochondria isolated from brain and heart tissue (1980) (69)
Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria. (2009) (69)
Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins (1998) (68)
The expression of heat shock protein 70 decreases with age in lymphocytes from rats and rhesus monkeys. (1995) (68)
Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes. (2003) (68)
Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. (2009) (67)
Calorie restriction alleviates the age‐related decrease in neural progenitor cell division in the aging brain (2013) (65)
GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis. (2008) (63)
Role of superoxide–nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase (2011) (63)
Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline (2018) (62)
Science fact and the SENS agenda (2005) (61)
Effect of dietary restriction on DNA repair and DNA damage. (1993) (60)
The effect of age on protein synthesis and ribosome aggregation to messenger RNA in rat liver. (1976) (60)
The role of insulin and insulin-like growth factor-I in mammalian ageing. (2004) (59)
CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice (2013) (59)
Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics. (2004) (59)
Expression of heat shock genes in hepatocytes is affected by age and food restriction in rats. (1995) (59)
Diet restriction increases apoptosis in the gut of aging rats. (1998) (58)
Influence of exercise on the immune function of rats of various ages. (1988) (57)
Changes in brain protein synthesis during the life span of male Fischer rats. (1980) (57)
Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life (2015) (57)
Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness (2018) (55)
Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. (2016) (55)
cDNA expression arrays reveal incomplete reversal of age-related changes in gene expression by calorie restriction (2000) (55)
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. (2006) (53)
The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase (2010) (51)
A comparison of protein synthesis by liver parenchymal cells isolated from Fischer F344 rats of various ages (1979) (51)
Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats. (1998) (51)
Comparative proteomics: characterization of a two-dimensional gel electrophoresis system to study the effect of aging on mitochondrial proteins (2003) (50)
Maintenance and induction of cytochrome P-450 in cultured rat hepatocytes. (1985) (50)
Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes. (2016) (50)
The role of macromolecular damage in aging and age-related disease. (2014) (49)
Sexually divergent DNA methylation patterns with hippocampal aging (2017) (48)
Mechanism of the age-related decline in lymphocyte proliferation: Role of IL-2 production and protein synthesis (1983) (47)
The reproductive toxicity of molinate and metabolites to the male rat: effects on testosterone and sperm morphology. (1998) (47)
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice (2003) (47)
Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. (2003) (46)
Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice (2016) (46)
Revisiting the genomic hypomethylation hypothesis of aging (2018) (45)
Food restriction retards age-related histological changes in rat small intestine. (1990) (45)
MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart. (2015) (43)
Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society. (2016) (43)
Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. (2015) (43)
Analysis and modulation of DNA repair in aging (1997) (43)
Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice. (2019) (41)
Molecular events in matrix protein metabolism in the aging kidney (2012) (41)
Comparison of the hepatic mixed function oxidase system of young, adult, and old non-human primates (Macaca nemestrina). (1985) (41)
Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. (2006) (40)
Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle. (2018) (39)
Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing (2017) (39)
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching (2019) (39)
A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated (2016) (39)
Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus) (2015) (39)
The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT. (1995) (37)
Age-related changes in isolated rat hepatocytes. Comparison of size, morphology, binucleation, and protein content (1981) (37)
Comparison of RNA synthesis by liver nuclei from rats of various ages (1978) (37)
Proteomic screening of glycoproteins in human plasma for frailty biomarkers. (2012) (37)
Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice. (2015) (37)
Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction‐induced fatigue or recovery (2010) (36)
Expression of heat shock protein 70 decreases with age in hepatocytes and splenocytes from female rats (1999) (36)
Decreased in vitro Mitochondrial Function is Associated with Enhanced Brain Metabolism, Blood Flow, and Memory in Surfl-Deficient Mice (2013) (36)
To help aging populations, classify organismal senescence (2019) (35)
Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates. (2009) (34)
Science fact and the SENS agenda. What can we reasonably expect from ageing research? (2005) (31)
Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress. (2021) (31)
Rapamycin, anti-aging, and avoiding the fate of Tithonus. (2013) (31)
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects (2020) (31)
Age-related changes in unscheduled DNA synthesis by rat hepatocytes. (1984) (31)
Enhancing Mitochondrial Respiration Suppresses Tumor Promoter TPA-Induced PKM2 Expression and Cell Transformation in Skin Epidermal JB6 Cells (2011) (31)
Effect of age and dietary restriction on expression of heat shock protein 70 in rat alveolar macrophages (1998) (30)
Attenuation of leukocyte-endothelium interaction by antioxidant enzymes. (2003) (30)
The increase in the induction of IL-2 expression with caloric restriction is correlated to changes in the transcription factor NFAT. (1997) (30)
MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models (2008) (30)
Expression of heat shock protein 70 in rat spleen lymphocytes is affected by age but not by food restriction. (1996) (30)
Hepatic response to oxidative injury in long‐lived Ames dwarf mice (2011) (30)
A novel approach for screening the proteome for changes in protein conformation. (2006) (29)
Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice. (2013) (29)
The age-related decline in interleukin-3 expression in mice. (1988) (28)
The development of a specific pathogen free (SPF) barrier colony of marmosets (Callithrix jacchus) for aging research (2017) (28)
Adaptive changes in structure of skeletal muscles from adult Sod1 homozygous knockout mice (2007) (28)
Aging and cancer: can mTOR inhibitors kill two birds with one drug? (2011) (28)
Cell-free protein synthesis by kidney from the aging female Fischer F344 rat. (1981) (27)
Food restriction retards age-related biochemical changes in rat small intestine. (1991) (27)
Food restriction attenuates age-related increase in the sensitivity of endothelial cells to oxidized lipids. (2004) (26)
Age-related decrease in the naive (OX22+) T cells in F344 rats (1994) (26)
Effects of Age and Caloric Restriction on Lipid Peroxidation : Measurement of Oxidative Stress by F 2-Isoprostane Levels (2005) (26)
Is Rapamycin a Dietary Restriction Mimetic? (2019) (26)
Age-related changes in protein, RNA and DNA content and protein synthesis in rat testes (1978) (26)
The Effect Of Gonadectomy And Estradiol On Sensitivity To Oxidative Stress (2009) (25)
The anti-ageing action of dietary restriction. (2001) (25)
Modulation of age-related changes in serum 1,25-dihydroxyvitamin D and parathyroid hormone by dietary restriction of Fischer 344 rats. (1988) (24)
Necroptosis increases with age and is reduced by dietary restriction (2018) (24)
Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice (2018) (23)
A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice. (2010) (23)
Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice (2016) (22)
Gene Expression and Protein Degradation (2011) (22)
Role of DNA methylation in the dietary restriction mediated cellular memory (2017) (21)
Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice (2020) (20)
Attenuation of liver insoluble protein carbonyls: indicator of a longevity determinant? (2011) (20)
Metabolic activation of aflatoxin B1 by liver tissue from male Fischer F344 rats of various ages (1981) (20)
Effect of aging and caloric restriction on the mitochondrial proteome (2007) (19)
The expression of granulocyte/macrophage colony-stimulating factor in activated mouse lymphocytes declines with age. (1990) (18)
Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction. (2009) (18)
Significant life extension by ten percent dietary restriction (2016) (18)
Cancer cachexia in a mouse model of oxidative stress (2020) (18)
Effect of aging and caloric restriction on the mitochondrial proteome. (2013) (17)
Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems (2020) (16)
Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by age and reserpine (1990) (16)
Effect of Maturation and Age on Lymphocyte Proliferation Induced by A23187 Through an Interleukin‐Independent Pathway (1985) (16)
Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia (2019) (16)
Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice. (2003) (16)
Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation (2016) (16)
Bring Back the Rat! (2020) (15)
The transcription of various types of ribonucleic acid by hepatocytes isolated from rats of various ages. (1982) (15)
Aging and lymphocyte cytoskeleton: age-related decline in the state of actin polymerization in T lymphocytes from Fischer F344 rats. (1987) (14)
Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice (2012) (14)
PGC‐1α‐Induced Mitochondrial Alterations in 3T3 Fibroblast Cells (2007) (14)
Effects of levamisole on primary cultures of adult rat hepatocytes. (1986) (14)
Effect of age on RNA synthesis by rat hepatocytes (1979) (14)
Influence of Dietary Restriction and Aging on Gene Expression in the Immune System of Rats (1990) (13)
Effect of overexpression of human Cu/Zn-SOD on activation-induced lymphocyte proliferation and apoptosis. (2001) (13)
Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia (2020) (13)
Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis (1987) (13)
The Geropathology Grading Platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging (2018) (13)
Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase (2012) (13)
Raising the antioxidant levels within mouse muscle fibres does not affect contraction‐induced injury (2006) (12)
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia (2020) (12)
Cadmium toxicity and distribution in metallothionein-I and -II deficient transgenic mice (1997) (12)
Lifelong reduction in complex IV induces tissue‐specific metabolic effects but does not reduce lifespan or healthspan in mice (2018) (11)
Effect of age on the expression of phosphoenolpyruvate carboxykinase in rat liver. (1994) (11)
Caloric Restriction, Aging and Oxidative Stress (2004) (11)
Aging and Oxidative Stress in Transgenic Mice (2002) (10)
The heat shock transcription factor in liver exists in a form that has DNA binding activity but no transcriptional activity. (1994) (10)
Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation. (2017) (10)
Cloning and characterization of a testis and brain-specific isoform of mouse 3′-phosphoinositide-dependent protein kinase-1, mPDK-1β (2002) (10)
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model (2021) (10)
Use of Transgenic Mice in Aging Research. (1997) (10)
Age-related changes in protein phosphorylation by rat hepatocytes (1989) (9)
Biochemical studies of chick brain development and maturation: II. Alterations in the mechanisms of cell-free protein synthesis (1977) (9)
You Have Come A Long Way Baby: Five Decades of Research on the Biology of Aging from the Perspective of a Researcher Studying Aging. (2020) (9)
Dietary restriction does not protect the nigrostriatal dopaminergic pathway of older animals from low-dose MPTP-induced neurotoxicity. (2003) (9)
PGC-1alpha-induced mitochondrial alterations in 3T3 fibroblast cells. (2007) (8)
Effect of sodium butyrate on primary cultures of adult rat hepatocytes (1987) (8)
Characterization of RNA synthesis by isolated hepatocytes in suspension. (1979) (8)
Effect of cAMP-induced transcription on the repair of the phosphoenolpyruvate carboxykinase gene by hepatocytes isolated from young and old rats. (1998) (8)
Induction of heat shock proteins in lymphocytes increases with mitogen stimulation. (1991) (7)
Detection and quantification of protein disulfides in biological tissues a fluorescence-based proteomic approach. (2010) (7)
Genetic expression of complement factors and α 1-acid glycoprotein by liver tissue during senescence (1986) (7)
Extension of Life Span in Laboratory Mice (2018) (7)
Early postnatal administration of growth hormone increases tuberoinfundibular dopaminergic neuron numbers in Ames dwarf mice. (2010) (6)
Inhibition of cell-free protein synthesis by analogues of aurintricarboxylic acid. (1978) (6)
Biochemical studies of chick brain development and maturation: I. Alterations in the macromolecule content and cell-free protein synthesis (1977) (6)
Rapamycin selectively alters serum chemistry in diabetic mice (2012) (6)
Thoughts on the evolutionary basis of dietary restriction (1994) (6)
Calorie restriction prevents age-related changes in the intestinal microbiota (2020) (5)
Metabolic profiles of rats of different ages (1984) (5)
mTOR: Alzheimer's disease prevention for APOE4 carriers (2016) (4)
Probing the in Vivo Relevance of Oxidative Stress in Aging Using Knockout and Transgenic Mice (2003) (4)
Increased Mutational Response to Carcinogens Haploinsufficiency : Accelerated DNA Damage and β Base Excision Repair Deficiency Caused by Polymerase Updated (2003) (4)
Effect of age on the interleukin 2 messenger RNA level (1985) (4)
Age-Related Changes in Adrenal Catecholamine Content and Tyrosine Hydroxylase Gene Expression: Effects of Dietary Restriction (1990) (4)
Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta. (2002) (4)
The Sam and Ann Barshop Center for Longevity and Aging Studies: The University of Texas Health Science Center at San Antonio (2002) (3)
Changes in Protein Turnover as a Function of Age and Nutritional Status (2000) (3)
Erratum: A novel approach for screening the proteome for changes in protein conformation (Biochemistry (March 2006) 45, 9 (3077-3085)) (2006) (3)
Effect of aging and dietary restriction on the expression of alpha 2u-globulin in two strains of rats. (1989) (2)
Leading Edge Commentary Geroscience : Linking Aging to Chronic Disease (2014) (2)
Understanding ageing by Robin Holliday, Cambridge University Press, Cambridge, England, ISBN 0-521-41788-0 (Hardback), ISBN 0-521-41788-2 (Paperback), 207 pp. $24.95 (1996) (2)
Effect of Age and Dietary Restriction on the Expression of aa ,-Globulin * (2001) (2)
Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock (2012) (2)
GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland (1990) (2)
Normal immune function in young and old DNA polymerase-β deficient mice (2000) (2)
Normal immune function in young and old DNA polymerase-beta deficient mice. (2000) (2)
The distinct in vivo roles of the long‐form and short‐form of glutathione peroxidase 4: the short‐form is essential for somatic cell functions and the long‐form is important for male fertility (2009) (1)
[721] OVEREXPRESSION OF MANGANESE SUPEROXIDE DISMUTASE TRIGGERS MITOCHONDRIA!. DAMAGE AFTER CHRONIC ALCOHOL INTOXICATION IN MOUSE LIVER (2007) (1)
Comparison of the extraction of RNA from rat liver by the diethyl pyrocarbonate-sodium dodecyl sulfate and phenol-chloroform methods. (1978) (1)
Sexually divergent DNA methylation programs with hippocampal aging (2017) (1)
Correction: Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease (2011) (1)
Abstract 582: Overexpression of Mnsod Reduces Aortic Valve Calcification Through Repression of Pro-osteogenic Signaling (2015) (1)
The inherent challenges of classifying senescence—Response (2020) (1)
Correction: Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease (2011) (1)
A textbook on drug metabolism. “Drug Metabolism and Drug Toxicity,” J.R. Mitchell and M.G. Horning (eds). New York: Raven Press, 1984, 448 pp, $78.00 (1985) (0)
Stress kinases: Altered in fibroblasts and liver of dwarf mice (2011) (0)
Role of necroptosis in chronic hepatic inflammation and liver disease in Cu/Zn superoxide dismutase deficient mice (2020) (0)
Long-term oral delivery of encapsulated rapamycin is not detrimental to immunity in old mice (2012) (0)
Male Breast Cancer Etiology: shared risk factors with a subset of female breast cancer? (2011) (0)
Litter expansion alters metabolic homeostasis in a sexually divergent manner (2020) (0)
Preserved Brain Metabolism in Aging with Mitochondrial Mutation (2011) (0)
A CONTRACTION PROTOCOL FOR STUDIES OF PHYSIOLOGICAL AND BIOCHEMICAL VARIABLES IN BOTH HIND LIMB MUSCLES OF MICE (2003) (0)
The use of cultured rat hepatocytes to study the repair of specific genes (1995) (0)
The effect of age on the ability of liver to metabolise aflatoxin B (1981) (0)
The error catastrophe theory of aging point counterpoint (1997) (0)
Effect of aging on the hepatic mixed function monoxygenase system from a non-human primate (Macaca nemestrina) (1984) (0)
Mitochondria-Generated Oxidative Stress is Altered by Subcellular Localization of MsrA Overexpression (2011) (0)
Nutritional modulation of aging: effect of caloric restriction (2003) (0)
Effect of age on lymphocyte proliferation induced by a calcium ionophore (1985) (0)
Intracellular Interactions of Superoxide and Nitric Oxide in Skeletal Muscle. (2010) (0)
Inducible motor neuron specific deletion of CuZn Superoxide dismutase accelerates muscle atrophy in mice (2017) (0)
The metabolism of aflatoxin B1 by isolated hepatocytes from rats of various ages (1982) (0)
Musculoskeletal changes in superoxide dismutase 1 null mice (1153.5) (2014) (0)
Age-related changes in the synthesis and phosphorylation of proteins (1986) (0)
The effect of aging on the induction of tyrosine amino transferase in hepatocytes isolated from male Fischer F344 rats (1984) (0)
The effect of phenobarbital on the synthesis of total RNA and cytochrome P-450b mRNA (1982) (0)
Abstract B59: Targeting metabolic enzymes in cancer prevention: Mechanistic insight into reciprocal regulation of isoforms of pyruvate kinase and isocitrate dehydrogenase in the early stage of cancer development (2011) (0)
Effect of cyclosporin A on the production of three lymphokines and the expression of their mRNAs in mice (1990) (0)
Comparison of cell-free protein synthesis by different regions of chicken brain (1978) (0)
Photoperiodically induced variation in testicular RNA, DNA and protein content in hamsters and ground squirrels. (1979) (0)
Altered Redox Signalling in both Muscle and Nerve are Required for Neuromuscular Breakdown (2020) (0)
Expression ofHeatShockProtein 70IsAltered byAgeand DietattheLevelofTranscription (1993) (0)
Caloric-restriction induced alterations in CG and non-CG methylation attenuate age-associated changes in the old brain (2017) (0)
fibers during development increased force generation by rat diaphragm muscle Selected Contribution: Mechanisms underlying (2015) (0)
Regulation of adherence-stimulated HSP-70 mRNA expression in alveolar macrophages (1996) (0)
Caloric-restriction mitigates age-associated alteration in CG and non-CG methylation in the old brain. (2017) (0)
The levels of several messenger RNA species in rat liver as a function of age (1985) (0)
Effect of age on granulocyte macrophage colony stimulating factor gmcsf (1987) (0)
Antioxidant overexpression reduces diaphragm maximal specific tension but does not alter resistance to fatigue (2007) (0)
breathing lipid peroxidation during loaded Oxypurinol administration fails to prevent free (2015) (0)
Effects of aging on gene specific repair (2001) (0)
Contents: proteomics 4/2007. (2007) (0)
Lack of SOD1 In Neuronal Tissue Affects Neuromuscular Junction Stability in Advanced Age (2020) (0)
MnSod deficiency causes significant mitochondrial abnormalities and contractile dysfunction in skeletal muscle, but does not decrease muscle mass (2017) (0)
Edward J. Masoro, Scientist and Friend. (2020) (0)
Flow-metabolism Uncoupling and Extended Longevity as Observed with a Transgenic Mice Model (2010) (0)
Impact of oxidative stress and mitochondrial dysfunction on the neuromuscular junction and age-related atrophy (2009) (0)
Brief communication Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS (2012) (0)
The Sam and Ann Barshop Center for Longevity and Aging Studies. Interview by Vicki Glaser. (2003) (0)
Mouse Health Span: Why Lifespan is No Longer Enough (2012) (0)
693 Manganese superoxide dismutase overexpression protects against hepatic mitochondrial dna depletion after an acute alcohol binge, yet aggravates mitochondrial DNA depletion after chronic alcohol intoxication in mice (2006) (0)
Age-related changes in the expression and methylation of specific genes in the liver (1984) (0)
Overexpression of CuZnSOD or MnSOD protects satellite cells from doxorubicin‐induced apoptosis (2007) (0)
Overexpression of MnSOD Does Not Improve Endothelial Function in Hypercholesterolemic Mice (2015) (0)
Do Thioredoxin 2 Transgenic and Thioredoxin 1 Knockout Mice Extend Lifespan through Different Mechanisms (2010) (0)
Targeting Metabolic Enzymes in Cancer Prevention: Reciprocal Regulation of Isoforms of Pyruvate Kinase and Isocitrate Dehydrogenase in the Early Stage of Cancer Development (2011) (0)
The Contribution of Environment to Impair Re‐Innervation in Age‐Related Failure of Muscle Regeneration Following Injury (2020) (0)
The ability of liver from male Fischer F344 rats to metabolize the chemical carcinogen aflatoxin declines with increasing age (1981) (0)
HOW WELL DOES THE FREE RADICAL THEORY OF AGING STAND UP TO EXPERIMENTAL TESTING (2012) (0)

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