Arne Holmgren
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Swedish biochemist
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Biology
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Molecular Biology
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Biochemistry
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Biology
Arne Holmgren's Degrees
- Masters Chemistry Uppsala University
Why Is Arne Holmgren Influential?
(Suggest an Edit or Addition)According to Wikipedia, Arne Holmgren was a Swedish biochemist known as a redox pioneer. He studied medicine at Uppsala University in 1962 and became a medical student. He received his Ph.D. in 1968 from the Karolinska Institute where he became associate professor in 1969, and became a certified doctor in 1974.
Arne Holmgren's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Physiological functions of thioredoxin and thioredoxin reductase. (2000) (2364)
- Thioredoxin and glutaredoxin systems. (2019) (1499)
- The thioredoxin antioxidant system. (2014) (1323)
- From selenium to selenoproteins: synthesis, identity, and their role in human health. (2007) (1189)
- Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide. (1979) (820)
- [21] Thioredoxin and thioredoxin reductase (1995) (778)
- Thioredoxin and related molecules--from biology to health and disease. (2007) (667)
- Unraveling the biological roles of reactive oxygen species. (2011) (653)
- The Role of the Thioredoxin and Glutaredoxin Pathways in Reducing Protein Disulfide Bonds in the Escherichia coliCytoplasm* (1997) (645)
- Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. (2004) (638)
- Rat liver thioredoxin and thioredoxin reductase: purification and characterization. (1982) (575)
- The thioredoxin system in cancer. (2006) (527)
- Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors. (2005) (505)
- Thioredoxin and thioredoxin reductase: current research with special reference to human disease. (2010) (496)
- Antioxidant function of thioredoxin and glutaredoxin systems. (2000) (478)
- Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide (2007) (459)
- Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence. (2000) (456)
- Thioredoxin and thioredoxin reductase. (1995) (453)
- Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide. (1995) (440)
- Thioredoxin Reductase Is Irreversibly Modified by Curcumin (2005) (432)
- Thiol redox control via thioredoxin and glutaredoxin systems. (2005) (423)
- Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione. (1976) (421)
- Inhibition of the Human Thioredoxin System (2008) (409)
- Essential Role of Selenium in the Catalytic Activities of Mammalian Thioredoxin Reductase Revealed by Characterization of Recombinant Enzymes with Selenocysteine Mutations* (2000) (401)
- Glutaredoxin systems. (2008) (388)
- Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution. (1975) (377)
- Redox Potentials of Glutaredoxins and Other Thiol-Disulfide Oxidoreductases of the Thioredoxin Superfamily Determined by Direct Protein-Protein Redox Equilibria* (1997) (376)
- S-Nitrosoglutathione Is Cleaved by the Thioredoxin System with Liberation of Glutathione and Redox Regulating Nitric Oxide* (1996) (350)
- Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells (1999) (344)
- Structural and functional relations among thioredoxins of different species (1991) (342)
- The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase. (1994) (340)
- Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems (2002) (336)
- Differential reactivity of the functional sulfhydryl groups of cysteine-32 and cysteine-35 present in the reduced form of thioredoxin from Escherichia coli. (1980) (329)
- Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system. (2007) (328)
- Cloning and Expression of a Novel Human Glutaredoxin (Grx2) with Mitochondrial and Nuclear Isoforms* (2001) (325)
- Preparation and assay of mammalian thioredoxin and thioredoxin reductase. (1999) (314)
- Human Thioredoxin Reductase Directly Reduces Lipid Hydroperoxides by NADPH and Selenocystine Strongly Stimulates the Reaction via Catalytically Generated Selenols(*) (1995) (308)
- Three-dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine-dependent enzyme (2001) (307)
- Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis. (2002) (304)
- Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. (2006) (300)
- Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase* (2004) (300)
- Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor. (2005) (281)
- Reduction of disulfides by thioredoxin. Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action. (1979) (280)
- Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. (2010) (270)
- Bovine thioredoxin system. Purification of thioredoxin reductase from calf liver and thymus and studies of its function in disulfide reduction. (1977) (267)
- Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity. (1990) (259)
- Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue* (1998) (258)
- Thioredoxins and glutaredoxins as facilitators of protein folding. (2008) (252)
- Mimicking the active site of protein disulfide-isomerase by substitution of proline 34 in Escherichia coli thioredoxin. (1991) (252)
- Probing the chemistry of thioredoxin catalysis with force (2007) (249)
- Interactions of CO with Pt/ceria catalysts (1999) (248)
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. (2016) (245)
- Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin. (1985) (240)
- Thioredoxin system in cell death progression. (2012) (235)
- Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen. (1992) (234)
- High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin. (1994) (230)
- Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14----S) and its mixed disulfide with glutathione. (1992) (227)
- Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant (2002) (226)
- Selenium and selenoproteins in health and disease. (2010) (222)
- High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes. (1999) (215)
- Thioredoxin and glutaredoxin systems (1989) (214)
- Thioredoxin. 6. The amino acid sequence of the protein from escherichia coli B. (1968) (212)
- Glutathione-dependent synthesis of deoxyribonucleotides. Purification and characterization of glutaredoxin from Escherichia coli. (1979) (212)
- Glutathione-dependent synthesis of deoxyribonucleotides. Characterization of the enzymatic mechanism of Escherichia coli glutaredoxin. (1979) (211)
- Elevation of plasma thioredoxin levels in HIV-infected individuals. (1996) (206)
- Selenoproteins* (2009) (203)
- Mammalian Thioredoxin Reductase Is Irreversibly Inhibited by Dinitrohalobenzenes by Alkylation of Both the Redox Active Selenocysteine and Its Neighboring Cysteine Residue* (1998) (196)
- Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. (2017) (190)
- Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. (1996) (189)
- Determination of the reduction-oxidation potential of the thioredoxin-like domains of protein disulfide-isomerase from the equilibrium with glutathione and thioredoxin. (1993) (186)
- Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma. (2001) (186)
- Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant. (1994) (185)
- 1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase (1995) (181)
- Glutathione and Glutaredoxin Act as a Backup of Human Thioredoxin Reductase 1 to Reduce Thioredoxin 1 Preventing Cell Death by Aurothioglucose* (2012) (180)
- Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. (2004) (180)
- Conformational and functional similarities between glutaredoxin and thioredoxins. (1984) (179)
- Effects of buried charged groups on cysteine thiol ionization and reactivity in Escherichia coli thioredoxin: structural and functional characterization of mutants of Asp 26 and Lys 57. (1997) (179)
- Selenoprotein Gene Nomenclature* (2016) (177)
- Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex. (2001) (175)
- Single-molecule paleoenzymology probes the chemistry of resurrected enzymes (2011) (174)
- Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation and S-Nitrosylation of Cysteine Residues* (2008) (173)
- Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia (2009) (172)
- Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I. (1986) (172)
- Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase. (1992) (168)
- A Novel Antioxidant Mechanism of Ebselen Involving Ebselen Diselenide, a Substrate of Mammalian Thioredoxin and Thioredoxin Reductase* (2002) (167)
- Reactivity of Glutaredoxins 1, 2, and 3 fromEscherichia coli Shows That Glutaredoxin 2 Is the Primary Hydrogen Donor to ArsC-catalyzed Arsenate Reduction* (1999) (165)
- Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release. (2005) (162)
- Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo. (2006) (159)
- Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione. (1993) (159)
- Immunohistochemical localization of thioredoxin and thioredoxin reductase in adult rats. (1985) (157)
- Protein Folding Drives Disulfide Formation (2012) (152)
- Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. (2004) (152)
- A Novel Monothiol Glutaredoxin (Grx4) from Escherichia coli Can Serve as a Substrate for Thioredoxin Reductase* (2005) (151)
- Motexafin Gadolinium, a Tumor-selective Drug Targeting Thioredoxin Reductase and Ribonucleotide Reductase* (2006) (151)
- Thioredoxin and thioredoxin reductase in relation to reversible S-nitrosylation. (2013) (150)
- Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. (2012) (149)
- New Thioredoxins and Glutaredoxins as Electron Donors of 3′-Phosphoadenylylsulfate Reductase* (1999) (148)
- Thioredoxin and related proteins in procaryotes. (1988) (148)
- Molecular Mechanisms of Thioredoxin and Glutaredoxin as Hydrogen Donors for Mammalian S Phase Ribonucleotide Reductase* (2009) (145)
- Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy. (1990) (145)
- Chronic elevation of plasma thioredoxin: Inhibition of chemotaxis and curtailment of life expectancy in AIDS (2001) (144)
- Transcriptional Regulation of Glutaredoxin and Thioredoxin Pathways and Related Enzymes in Response to Oxidative Stress* (2000) (138)
- Enzymatic reduction-oxidation of protein disulfides by thioredoxin. (1984) (138)
- Hypersensitive reactions and antibody formation during L‐asparaginase treatment of children and adults with acute leukemia (1976) (137)
- The nuclear magnetic resonance solution structure of the mixed disulfide between Escherichia coli glutaredoxin(C14S) and glutathione. (1994) (135)
- Tissue distrubution and subcellular localization of bovine thioredoxin determined by radioimmunoassay. (1978) (135)
- Tryptophan fluorescence study of conformational transitions of the oxidized and reduced form of thioredoxin. (1972) (135)
- Measurement of Thioredoxin and Thioredoxin Reductase (2005) (134)
- Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione (2013) (133)
- NMR structure of Escherichia coli glutaredoxin 3-glutathione mixed disulfide complex: implications for the enzymatic mechanism. (1999) (132)
- Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention. (2010) (128)
- Chaperone properties of Escherichia coli thioredoxin and thioredoxin reductase. (2003) (128)
- Molecular and Structural Basis for Redox Regulation of β-Actin (2007) (128)
- Selenium and the thioredoxin and glutaredoxin systems. (1997) (126)
- Up‐regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma (2001) (126)
- Measurements of plasma glutaredoxin and thioredoxin in healthy volunteers and during open-heart surgery. (1998) (125)
- Secretion of thioredoxin after in vitro activation of human B cells. (1992) (124)
- Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II). (1999) (124)
- Inhibition of AP-1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos. (1998) (123)
- Glutaredoxin Protects Cerebellar Granule Neurons from Dopamine-induced Apoptosis by Activating NF-κB via Ref-1* (2001) (121)
- Thioredoxin and glutaredoxin isoforms. (2002) (119)
- NMR structure of oxidized Escherichia coli glutaredoxin: Comparison with reduced E. coli glutaredoxin and functionally related proteins (1992) (117)
- Thioredoxin or glutaredoxin in Escherichia coli is essential for sulfate reduction but not for deoxyribonucleotide synthesis (1990) (116)
- Truncated Thioredoxin Is a Mitogenic Cytokine for Resting Human Peripheral Blood Mononuclear Cells and Is Present in Human Plasma* (2000) (115)
- Comparison of backbone and tryptophan side-chain dynamics of reduced and oxidized Escherichia coli thioredoxin using 15N NMR relaxation measurements. (1993) (115)
- Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning (2011) (113)
- A CD4+ T cell line-secreted factor, growth promoting for normal and leukemic B cells, identified as thioredoxin. (1995) (110)
- Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase (2014) (110)
- Truncated thioredoxin: physiological functions and mechanism. (2004) (110)
- The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity. (2011) (109)
- Characterization of Escherichia coli NrdH (1997) (108)
- Thioredoxin 2: cleavage with cyanogen bromide. (1967) (106)
- Glutaredoxin from calf thymus. Purification to homogeneity. (1982) (106)
- Conserved immunoglobulin‐like features in a family of periplasmic pilus chaperones in bacteria. (1992) (105)
- The Redox State of SECIS Binding Protein 2 Controls Its Localization and Selenocysteine Incorporation Function (2006) (105)
- How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2? (2007) (102)
- Oxidation and S-Nitrosylation of Cysteines in Human Cytosolic and Mitochondrial Glutaredoxins (2007) (101)
- The thioredoxin superfamily in oxidative protein folding. (2014) (101)
- A Pro to His mutation in active site of thioredoxin increases its disulfide-isomerase activity 10-fold. New refolding systems for reduced or randomly oxidized ribonuclease. (1992) (100)
- Cellular and plasma levels of human glutaredoxin 1 and 2 detected by sensitive ELISA systems. (2004) (99)
- Expression analysis of the nrdHIEF operon from Escherichia coli. Conditions that trigger the transcript level in vivo. (2001) (98)
- Expression pattern of human glutaredoxin 2 isoforms: identification and characterization of two testis/cancer cell-specific isoforms. (2008) (97)
- Poorly humified peat as an adsorbent for metals in wastewater. (2002) (96)
- Visualization of the compartmentalization of glutathione and protein‐glutathione mixed disulfides in cultured cells (2003) (95)
- Oxygen Storage Dynamics in Pt/CeO2/Al2O3Catalysts☆ (1998) (95)
- Regulation of ribonucleotide reductase. (1981) (95)
- Glutathione-dependent hydrogen donor system for calf thymus ribonucleoside-diphosphate reductase. (1979) (95)
- The role of thioredoxin in the regulation of cellular processes by S-nitrosylation. (2012) (95)
- Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase. (2009) (94)
- Cloning, Overexpression, and Characterization of Glutaredoxin 2, An Atypical Glutaredoxin from Escherichia coli* (1997) (94)
- Substitution of the conserved tryptophan 31 in Escherichia coli thioredoxin by site-directed mutagenesis and structure-function analysis. (1991) (91)
- Thioredoxin: structure and functions (1981) (89)
- The use of thiols by ribonucleotide reductase. (2010) (89)
- Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases. (2001) (89)
- Sequence-specific 1H n.m.r. assignments and determination of the three-dimensional structure of reduced Escherichia coli glutaredoxin. (1991) (87)
- Proton sharing between cysteine thiols in Escherichia coli thioredoxin: implications for the mechanism of protein disulfide reduction. (1995) (86)
- Reversible Silencing of CFTR Chloride Channels by Glutathionylation (2005) (85)
- Thioredoxin expression and localization in human cell lines: detection of full-length and truncated species. (1997) (85)
- Thioredoxin reductase and glutathione synthesis is upregulated by t‐butylhydroquinone in cortical astrocytes but not in cortical neurons (2000) (84)
- Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. (2004) (84)
- A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase. (2012) (83)
- Glutaredoxin Protects Cerebellar Granule Neurons from Dopamine-induced Apoptosis by Dual Activation of the Ras-Phosphoinositide 3-Kinase and Jun N-terminal Kinase Pathways* (2001) (82)
- Reduction of purothionin by the wheat seed thioredoxin system. (1987) (81)
- Two resident ER‐proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: comparison with protein disulfide isomerase (1995) (81)
- Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes. (2001) (81)
- Diversity of Chemical Mechanisms in Thioredoxin Catalysis Revealed by Single-Molecule Force Spectroscopy (2009) (80)
- Assignment of the proton NMR spectrum of reduced and oxidized thioredoxin: sequence-specific assignments, secondary structure, and global fold. (1989) (80)
- Thioredoxin and glutaredoxin systems : structure and function (1986) (80)
- Thioredoxin 1 Is Inactivated Due to Oxidation Induced by Peroxiredoxin under Oxidative Stress and Reactivated by the Glutaredoxin System* (2013) (80)
- Identification, expression pattern, and characterization of mouse glutaredoxin 2 isoforms. (2009) (80)
- Inhibition of the thioredoxin system in the brain and liver of zebra-seabreams exposed to waterborne methylmercury. (2011) (80)
- A conformational study of thioredoxin and its tryptic fragments. (1981) (79)
- Vertebrate-specific glutaredoxin is essential for brain development (2011) (79)
- Mass transfer in monolith catalysts–CO oxidation experiments and simulations (1998) (78)
- The primary structure of Escherichia coli glutaredoxin (1983) (78)
- Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin. (1995) (77)
- Picosecond tryptophan fluorescence of thioredoxin: evidence for discrete species in slow exchange. (1989) (77)
- Thioredoxin increases the proliferation of human B-cell lines through a protein kinase C-dependent mechanism. (1994) (76)
- Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase. (2014) (76)
- Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1 (2013) (75)
- Selenite and selenate inhibit human lymphocyte growth via different mechanisms. (1996) (75)
- A model of oxygen transport in Pt/ceria catalysts from isotope exchange (1999) (74)
- Isolation and characterization of calf liver thioredoxin. (1974) (74)
- Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase. (1980) (72)
- Thioredoxin Reductase Is Irreversibly Modified by Curcumin A NOVEL MOLECULAR MECHANISM FOR ITS ANTICANCER ACTIVITY* (2005) (72)
- Fifty years in the thioredoxin field and a bountiful harvest. (2012) (71)
- Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic. (2018) (71)
- Localization of thioredoxin in the rat brain and functional implications (1995) (71)
- Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds. (2014) (71)
- Thiroedoxin from Escherichia coli. Radioimmunological and enzymatic determinations in wild type cells and mutants defective in phage T7 DNA replication. (1978) (70)
- Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential (2007) (68)
- Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium‐deficient rat liver (2009) (68)
- Glutaredoxin-3 from Escherichia coli (1996) (67)
- Protein Levels of Escherichia coli Thioredoxins and Glutaredoxins and Their Relation to Null Mutants, Growth Phase, and Function* (2002) (67)
- A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins. (2007) (65)
- Relative contributions of thioltransferase-and thioredoxin-dependent systems in reduction of low-molecular-mass and protein disulphides. (1983) (65)
- The Contributions of Protein Disulfide Isomerase and Its Homologues to Oxidative Protein Folding in the Yeast Endoplasmic Reticulum* (2004) (65)
- [22] Selenite and selenodiglutathione: Reactions with thioredoxin systems (1995) (64)
- Proton-transfer effects in the active-site region of Escherichia coli thioredoxin using two-dimensional 1H NMR. (1991) (63)
- The binding of insulin and somatomedin A to human placental membrane. (1975) (63)
- Molecular and structural basis for redox regulation of beta-actin. (2007) (61)
- Molecular Mapping of Functionalities in the Solution Structure of Reduced Grx4, a Monothiol Glutaredoxin from Escherichia coli* (2005) (61)
- Direct NMR observation of the Cys‐14 thiol proton of reduced Escherichia coli glutaredoxin‐3 supports the presence of an active site thiol‐thiolate hydrogen bond (1999) (61)
- Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes. (2011) (61)
- Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin system. Strong synergistic effects with protein disulphide-isomerase. (1992) (60)
- Enzymatic reduction of disulfide bonds in fibrin-ogen by the thioredoxin system. I. Identification of reduced bonds and studies on reoxidation process. (1974) (60)
- The Levels of Ribonucleotide Reductase, Thioredoxin, Glutaredoxin 1, and GSH Are Balanced in Escherichia coli K12* (1996) (60)
- Thioredoxin blood level increases after severe burn injury. (2000) (60)
- Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region. (1984) (60)
- Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity (2008) (57)
- Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion. (2001) (57)
- Thioredoxin. A localized conformational change accompanying reduction of the protein to the sulfhydryl form. (1967) (57)
- Redox properties and evolution of human glutaredoxins (2007) (57)
- Influence of pre-treatment on the low-temperature activity of Pt/Ceria (1999) (57)
- Redox Regulation of 3′-Phosphoadenylylsulfate Reductase from Escherichia coli by Glutathione and Glutaredoxins* (2003) (57)
- cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase. (1986) (56)
- Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties (2017) (56)
- A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8 (2017) (56)
- The Thioredoxin-like Protein Rod-derived Cone Viability Factor (RdCVFL) Interacts with TAU and Inhibits Its Phosphorylation in the Retina* (2009) (56)
- Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems. (2018) (56)
- NADPH-dependent and -independent disulfide reductase systems. (2018) (55)
- Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury (2017) (55)
- Expression of the thioredoxin system in interstitial lung disease (2003) (54)
- The in vivo distribution of oxidized and reduced thioredoxin in Escherichia coli. (1982) (54)
- Glutaredoxin Accelerates Glutathione-dependent Folding of Reduced Ribonuclease A Together with Protein Disulfide-isomerase (*) (1995) (54)
- The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker? (2018) (53)
- Characterization of Escherichia coli Null Mutants for Glutaredoxin 2* (2002) (53)
- Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase (2017) (53)
- Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters. (1999) (53)
- Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron. (1996) (53)
- The role of sulfhydryl groups in permitting transformation and DNA binding of the glucocorticoid receptor. (1987) (52)
- Glutathione-dependent enzyme reactions of the phage T4 ribonucleotide reductase system. (1978) (52)
- Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production (2018) (51)
- Synergistic antibacterial effect of silver and ebselen against multidrug‐resistant Gram‐negative bacterial infections (2017) (51)
- Enzymatic synthesis of deoxyribonucleotides, 8. The effects of ATP and dATP in the CDP reductase system from E. coli. (1965) (50)
- Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis. (2016) (50)
- Changes in the distribution of insulin-like growth factor I, thioredoxin, thioredoxin reductase and ribonucleotide reductase during the development of the retina. (1989) (49)
- cDNA clones coding for the β‐subunit of human liver alcohol dehydrogenase have differently sized 3'‐non‐coding regions (1986) (49)
- Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4-hydroxynonenal. (2014) (49)
- Construction and characterization of glutaredoxin-negative mutants of Escherichia coli. (1988) (49)
- Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency. (2002) (48)
- Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier (2016) (48)
- Truncated thioredoxin (Trx80) exerts unique mitogenic cytokine effects via a mechanism independent of thiol oxido‐reductase activity (2003) (47)
- Truncated thioredoxin (Trx80) induces differentiation of human CD14+ monocytes into a novel cell type (TAMs) via activation of the MAP kinases p38, ERK, and JNK. (2005) (47)
- Photosynthetic regulatory protein from rabbit liver is identical with thioredoxin (1977) (46)
- Activity assays of mammalian thioredoxin and thioredoxin reductase: fluorescent disulfide substrates, mechanisms, and use with tissue samples. (2014) (46)
- NMR structure of oxidized glutaredoxin 3 from Escherichia coli. (2000) (46)
- Structural Basis for the Thioredoxin-like Activity Profile of the Glutaredoxin-like NrdH-redoxin from Escherichia coli* (2001) (45)
- The primary structure of calf thymus glutaredoxin. Homology with the corresponding Escherichia coli protein but elongation at both ends and with an additional half-cystine/cysteine pair. (1984) (45)
- Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246 (2018) (44)
- Catalysis of Thiol/Disulfide Exchange (2005) (44)
- Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells (2014) (44)
- Immunochemical characterization and tissue distribution of glutaredoxin (thioltransferase) from calf. (1993) (43)
- Selenite and selenodiglutathione: reactions with thioredoxin systems. (1995) (42)
- Hypoxia inducible factor‐alpha activation in lymphoma and relationship to the thioredoxin family (2008) (42)
- Axoplasmic transport of thioredoxin and thioredoxin reductase in rat sciatic nerve (1985) (42)
- Charcot–Marie–Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments (2013) (41)
- Ebsulfur Is a Benzisothiazolone Cytocidal Inhibitor Targeting the Trypanothione Reductase of Trypanosoma brucei * (2013) (41)
- In Vivo Transcription of nrdAB Operon and of grxA and fpg Genes Is Triggered inEscherichia coli Lacking both Thioredoxin and Glutaredoxin 1 or Thioredoxin and Glutathione, Respectively* (1998) (40)
- Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells (2017) (39)
- Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain (2012) (39)
- Immunohistochemical localization of glutaredoxin and thioredoxin in human endometrium: a possible association with pinopodes. (2002) (39)
- Characterization of the redox properties of poplar glutaredoxin. (2003) (39)
- Unique gene organization of thioredoxin and thioredoxin reductase in Mycobacterium leprae (1995) (39)
- Liquid-Phase Hydrogenation of Acetylene in a Monolithic Catalyst Reactor (1995) (38)
- Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma (2004) (38)
- Thiols decrease cytokine levels and down‐regulate the expression of CD30 on human allergen‐specific T helper (Th) 0 and Th2 cells (2001) (38)
- Deoxyribonucleoside triphosphate pools and growth of glutathione-depleted 3T6 mouse fibroblasts. (1996) (38)
- [68] Glutaredoxin from Escherichia coli and calf thymus (1985) (38)
- Enzymic Reduction of Disulfide Bonds by Thioredoxin (1976) (38)
- Bacillus anthracis Thioredoxin Systems, Characterization and Role as Electron Donors for Ribonucleotide Reductase* (2012) (38)
- Isolation and characterization of thioredoxin from the cyanobacterium, Anabaena sp. (1981) (37)
- Thioredoxin and glutaredoxin: small multi-functional redox proteins with active-site disulphide bonds. (1988) (36)
- Neurofilament phosphorylation and their proline‐directed kinases in health and disease (2012) (36)
- Calcium binding of bovine protein S. Effect of thrombin cleavage and removal of the gamma-carboxyglutamic acid-containing region. (1986) (36)
- High-resolution structures of oxidized and reduced thioredoxin reductase from Helicobacter pylori. (2007) (35)
- Thioredoxin-dependent regulation of AIF-mediated DNA damage. (2015) (34)
- Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori. (2016) (34)
- Structural differences between oxidized and reduced thioredoxin monitored by two‐dimensional 1H NMR spectroscopy (1988) (34)
- Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients (2012) (34)
- In vivo redox state of human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). (2012) (34)
- Pyridine nucleotide - disulfide oxidoreductases. (1980) (34)
- The primary structure of thioredoxin from the filamentous cyanobacterium Anabaena sp. 7119. (1985) (34)
- Redox regulation by thioredoxin and thioredoxin reductase. (2000) (34)
- MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation (2018) (33)
- Requirements for the different cysteines in the chemotactic and desensitizing activity of human thioredoxin. (2005) (33)
- The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress. (2019) (33)
- Reactivity of glutaredoxins 1, 2 and 3 from Escherichia coli and protein disulfide isomerase towards glutathionyl‐mixed disulfides in ribonuclease A (1999) (33)
- Nucleotide sequence of the thioredoxin gene fromEscherichia coli (1984) (32)
- The primary structure of Escherichia coli glutaredoxin. Distant homology with thioredoxins in a superfamily of small proteins with a redox-active cystine disulfide/cysteine dithiol. (1983) (32)
- Assignment of the 15N NMR spectra of reduced and oxidized Escherichia coli thioredoxin (1991) (32)
- Cloning and expression of the glutaredoxin (grx) gene of Escherichia coli. (1986) (31)
- Decreased expression of thioredoxin and glutaredoxin in placentae from pregnancies with pre-eclampsia and intrauterine growth restriction. (2000) (31)
- Reconstitution of Escherichia coli thioredoxin from complementing peptide fragments obtained by cleavage at methionine-37 or arginine-73. (1975) (31)
- EPR investigation of the active site of recombinant human 5-lipoxygenase: inhibition by selenide. (2001) (31)
- A mutant thioredoxin from Escherichia coli tsnC 7007 that is nonfunctional as subunit of phage T7 DNA polymerase. (1981) (31)
- Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions. (2009) (31)
- Structure and enzymatic functions of thioredoxin refolded by complementation of two tryptic peptide fragments. (1979) (30)
- Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth. (2002) (30)
- Genetic control of ocular morphogenesis: defective lens development associated with ocular anomalies in C57BL/6 mice. (1993) (30)
- Studies on the structure of T4 thioredoxin. II. Amino acid sequence of the protein and comparison with thioredoxin from Escherichia coli. (1972) (30)
- Biomarkers of Adverse Response to Mercury: Histopathology versus Thioredoxin Reductase Activity (2012) (30)
- Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems. (2004) (30)
- Yeast thioredoxin. Amino-acid sequence around the active-center disulfide of thioredoxin I and II. (1971) (29)
- Crystallization and preliminary crystallographic data for thioredoxin from Escherichia coli B. (1970) (29)
- Improved flow distribution in automotive monolithic converters (1997) (29)
- Ultrastructural demonstration of thioredoxin and thioredoxin reductase in rat hepatocytes. (1988) (29)
- Ebselen: A thioredoxin reductase-dependent catalyst for α-tocopherol quinone reduction (2005) (29)
- Iron‐sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia (2017) (29)
- Stimulation of Fe–S cluster insertion into apoFNR by Escherichia coli glutaredoxins 1, 2 and 3 in vitro (2004) (28)
- The expression of thioredoxin mRNA is increased in the human cervix during pregnancy. (1997) (28)
- Human spermatid‐specific thioredoxin‐1 (Sptrx‐1) is a two‐domain protein with oxidizing activity (2002) (28)
- Nuclear magnetic resonance studies of redox‐induced conformational changes in thioredoxin from Escherichia coli (1976) (28)
- Expression of Escherichia coli Glutaredoxin 2 Is Mainly Regulated by ppGpp and ςS * (2002) (28)
- Human IgG is substrate for the thioredoxin system: differential cleavage pattern of interchain disulfide bridges in IgG subclasses. (1997) (28)
- Immunolocalization of thioredoxin and glutaredoxin in mammalian hypophysis (1992) (28)
- Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability. (2008) (27)
- The function of thioredoxin and glutathione in deoxyribonucleic acid synthesis. (1977) (27)
- Null thioredoxin and glutaredoxin Escherichia coli K-12 mutants have no enhanced sensitivity to mutagens due to a new GSH-dependent hydrogen donor and high increases in ribonucleotide reductase activity. (1994) (26)
- PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12. (2005) (26)
- Fluorescently labeled model DNA sequences for exonucleolytic sequencing. (2001) (26)
- Purification and Functional Analysis of the Mycobacterium leprae Thioredoxin/Thioredoxin Reductase Hybrid Protein (*) (1995) (25)
- Characterization by 1H NMR of a C32S,C35S double mutant of Escherichia coli thioredoxin confirms its resemblance to the reduced wild‐type protein (1994) (25)
- Different cellular distribution of thioredoxin and subunit M1 of ribonucleotide reductase in rat tissues. (1986) (24)
- Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1. (2013) (24)
- Thioredoxin reductase-mediated hydrogen transfer from Escherichia coli thioredoxin-(SH)2 to phage T4 thioredoxin-S2. (1975) (24)
- Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase (2020) (24)
- Structure of oxidized thioredoxin to 4 with 5 A resolution. (1974) (24)
- Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes (2014) (24)
- Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway. (2015) (24)
- Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients (2015) (23)
- Selenite in cancer therapy: a commentary on "Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress". (2006) (23)
- Mammalian thioredoxin reductases as hydroperoxide reductases. (2002) (23)
- Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites (2020) (23)
- SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. (2010) (23)
- The thioredoxin system in cancer-introduction to a thematic volume of Seminars in Cancer Biology. (2006) (23)
- The expression of glutaredoxin is increased in the human cervix in term pregnancy and immediately post-partum, particularly after prostaglandin-induced delivery. (2000) (22)
- Immunoelectron microscopic localization of glutaredoxin and thioredoxin in Escherichia coli cells (1981) (22)
- Cellular Redox Systems Impact the Aggregation of Cu,Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis* (2016) (22)
- Catalyst deactivation in liquid- and gas-phase hydrogenation of acetylene using a monolithic catalyst reactor (1995) (21)
- Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1. (2015) (21)
- Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). (2009) (21)
- Characterization of homogeneous recombinant glutaredoxin from Escherichia coli: purification from an inducible lambda PL expression system and properties of a novel elongated form. (1991) (21)
- Thioredoxin messenger ribonucleic acid is regulated by estradiol in the rat uterus. (1997) (21)
- Effect of disulfide bridge formation on the NMR spectrum of a protein: Studies on oxidized and reduced Escherichia coli thioredoxin (1994) (20)
- Thioredoxin-C': mechanism of noncovalent complementation and reactions of the refolded complex and the active site containing fragment with thioredoxin reductase. (1979) (20)
- Structure-function relationships of human factor VIII complex studied by thioredoxin dependent disulfide reduction. (1984) (20)
- Characterization of bacteriophage T7 DNA polymerase purified to homogeneity by antithioredoxin immunoadsorbent chromatography. (1981) (20)
- Purification of a sulphation factor from skeletal muscle of rat. (1970) (20)
- The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins (2009) (20)
- Replacement of Trp in Escherichia coli Thioredoxin by Site-directed Mutagenesis Affects Thermodynamic Stability but Not Function (*) (1996) (20)
- Reduction of factor VIII and other coagulation factors by the thioredoxin system. (1979) (19)
- Thioredoxin 80-Activated-Monocytes (TAMs) Inhibit the Replication of Intracellular Pathogens (2011) (19)
- Immunohistochemical determination of thioredoxin and glutaredoxin distribution in the human cervix ,and possible relation to cervical ripening (2003) (19)
- Characterization of mammalian thioredoxin reductase, thioredoxin and glutaredoxin by immunochemical methods. (1995) (19)
- Calcium-dependent interaction between gamma-carboxyglutamic acid-containing and N-terminal epidermal growth factor-like modules in factor X. (1994) (19)
- Amino acid sequence determination and three-dimensional modelling of thioredoxin from the photosynthetic bacterium Rhodobacter sphaeroides Y. (1988) (19)
- Characterization of mammalian glutaredoxin isoforms as S‐denitrosylases (2019) (18)
- NMR characterization of a single-cysteine mutant of Escherichia coli thioredoxin and a covalent thioredoxin-peptide complex. (1998) (18)
- SNO Removal (2008) (18)
- Thioredoxin from Escherichia coli (1978) (18)
- Immunochemistry of thioredoxin. I. Preparation and cross-reactivity of antibodies against thioredoxin from Escherichia coli and bacteriophage T4. (1972) (18)
- Motion of aromatic side chains, picosecond fluorescence, and internal energy transfer in Escherichia coli thioredoxin studied by site-directed mutagenesis, time-resolved fluorescence spectroscopy, and molecular dynamics simulations. (1991) (18)
- Purification of thioredoxin from Escherichia coli and bacteriophage T4 by immunoadsorbent affinity chromatography. (1973) (17)
- Glutathione-dependent Synthesis of Deoxyribonucleotides PURIFICATION AND CHARACTERIZATION OF GLUTAREDOXIN FROM COLI* (2001) (17)
- Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium (2018) (17)
- Nuclear magnetic resonance studies of recombinant Escherichia coli glutaredoxin. Sequence-specific assignments and secondary structure determination of the oxidized form. (1991) (17)
- Determination of glutaredoxin enzyme activity and protein S-glutathionylation using fluorescent eosin-glutathione. (2016) (16)
- Thioredoxin. 4. Amino acid sequence of peptide B. (1968) (16)
- Characterization of the thioredoxin system in the facultative phototroph Rhodobacter sphaeroides Y. (1986) (16)
- Subunits of human alpha 2-macroglobulin produced by specific reduction of interchain disulfide bonds with thioredoxin. (1988) (16)
- An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin. (2013) (16)
- Bacterial thioredoxin and thioredoxin reductase as mediators for epigallocatechin 3‐gallate‐induced antimicrobial action (2016) (15)
- The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43. (2007) (15)
- Glutathione-glutaredoxin is an efficient electron donor system for mammalian p53R2–R1-dependent ribonucleotide reductase (2019) (15)
- Regulation of thioredoxin mRNA in the rat uterus by gonadal steroids (1999) (15)
- Glutathione derivatives as inhibitors of glutaredoxin and ribonucleotides reductase from Escherichia coli (1982) (15)
- The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase. (2019) (15)
- Enhanced Mass Transfer in Monolith Catalysts with Bumps on the Channel Walls (1999) (15)
- Immunohistochemical localization of thioredoxin and thioredoxin reductase in mouse exocrine and endocrine pancreas (2004) (14)
- Identification, expression pattern and characterization of mouse glutaredoxin 2 isoforms (2006) (14)
- Thioredoxin. 3. Amino acid sequences of the peptic peptides from S-aminoethylated peptide B. (1968) (14)
- Real-time Kinetics of the Interaction between the Two Subunits, Escherichia coli Thioredoxin and Gene 5 Protein of Phage T7 DNA Polymerase* (2003) (14)
- Imbalance in Protein Thiol Redox Regulation and Cancer-Preventive Efficacy of Selenium. (2016) (14)
- Studies on antibody formation in patients treated with L-asparaginase. (1970) (14)
- Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction. (2005) (14)
- Targeting bacterial antioxidant systems for antibiotics development. (2020) (13)
- Selective N-bromosuccinimide oxidation of the nonfluorescent tryptophan-31 in the active center of thioredoxin from Escherichia coli. (1981) (13)
- Thioredoxin and glutathione in cultured fibroblasts from human cases with 5‐oxoprolinuria and cystinosis (1978) (13)
- T7 DNA polymerase is not a zinc-metalloenzyme and the polymerase and exonuclease activities are inhibited by zinc ions. (1984) (13)
- Catalysis of Thiol/Disulfide Exchange: Glutaredoxin 1 and Protein Disulfide Isomerase use Different Mechanisms to Enhance Oxidase and Reductase Activities (2005) (13)
- Complete 1H, 13C, and 15N NMR resonance assignments and secondary structure of human glutaredoxin in the fully reduced form (1997) (13)
- Bacteriophage T7 DNA polymerase: cloning and high-level expression. (1985) (13)
- Human glutaredoxin 2 affinity tag for recombinant peptide and protein purification. (2006) (13)
- Reversible chemical modification of the tryptophan residues of thioredoxin from Escherichia coli B. (1972) (12)
- Effects of oxidation of tryptophan residues in thioredoxin from Escherichia coli by N-bromosuccinimide. (1973) (12)
- Folding of protein fragments: Conformational and biological studies on thioredoxin and its fragments (1983) (12)
- Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury. (2020) (12)
- Thioredoxin and thioredoxin reductase in pancreatic islets may participate in diabetogenic free-radical production. (1982) (12)
- Selenoproteins of the thioredoxin system (2011) (12)
- Thioredoxin and thioredoxin reductase in thiol redox control (2006) (12)
- The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14. (1996) (11)
- The heat-stable cytosolic factor that promotes glucocorticoid receptor binding to DNA is neither thioredoxin nor ribonuclease. (1987) (11)
- Bacterial and mammalian thioredoxin systems activate iodothyronine 5'-deiodination. (1988) (11)
- Thioredoxin reductase-dependent insulin disulfide reduction by phage T7 DNA polymerase reflects dissociation of the enzyme into subunits. (1989) (11)
- Monoclonal antibodies to human thioredoxin reductase. (1998) (11)
- Thioredoxin‐C′: Reconstitution of an active form of Escherichia coli thioredoxin from two noncovalently linked cyanogen bromide peptide fragments (1972) (10)
- Selenium status in diet affects acetaminophen-induced hepatotoxicity via interruption of redox environment. (2020) (10)
- Thioredoxin and thioredoxin reductase show function-related changes in the gastric mucosa: immunohistochemical evidence. (1988) (10)
- Thioredoxin. 5. Amino acid sequences of the tryptic peptides of peptide A. (1968) (9)
- Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease (2018) (9)
- Enzyme reduction of disulfide bonds by thioredoxin. The reactivity of disulfide bonds in human choriogonadotropin and its subunits. (1976) (8)
- Biosynthetic 15N and 13C isotope labelling of glutathione in the mixed disulfide with Escherichia coli glutaredoxin documented by sequence-specific NMR assignments. (1993) (8)
- Purification, crystallization and preliminary crystallographic data for rat cytosolic selenocysteine 498 to cysteine mutant thioredoxin reductase. (2000) (8)
- Partial oxidation of methane to synthesis gas—Experimental and modelling studies (1997) (7)
- Preliminary X-ray study of papD crystals from uropathogenic Escherichia coli. (1988) (7)
- Ascorbate and endocytosed Motexafin gadolinium induce lysosomal rupture. (2011) (7)
- Solution structure and biophysical properties of MqsA, a Zn-containing antitoxin from Escherichia coli. (2012) (7)
- Degradation of somatomedins by the thioredoxin system (1985) (6)
- Glutaredoxin from Escherichia coli and calf thymus. (1985) (6)
- A thioredoxin induced by bacteriophage T4. 3. Amino acid sequence around the active center disulfide. (1970) (6)
- Function of thioredoxin in oxidoreductions and as a subunit of phage-T7 deoxyribonucleic acid polymerase. (1978) (6)
- Rapid isolation of homogeneous cloned T7 gene 5 protein and T7 DNA polymerase by affinity chromatography on immobilized thioredoxin. (1991) (6)
- Letter to the Editor: Assignment of 1H, 13C, and 15N resonances of reduced Escherichia coli glutaredoxin 2 (1999) (6)
- Redox Regulation of Genes and Cell Function (2002) (6)
- Mammalian thioredoxin reductase (2001) (5)
- Inhibition of the thioredoxin system by PX-12 (1-methylpropyl 2-imidazolyl disulfide) impedes HIV-1 infection in TZM-bl cells (2019) (5)
- Molecular Biology of Small Heat Shock Proteins associated with Peripheral Neuropathies (2012) (5)
- Redox regulation by thioredoxin and glutaredoxin systems (2002) (5)
- Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigmaS. (2002) (5)
- Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain (2020) (5)
- Inhibition of Thioredoxin Reductase by Triosmium Carbonyl Clusters. (2020) (5)
- Thiols of Thioredoxin and Glutaredoxin in Redox Signaling (2003) (5)
- The Role of Thioredoxin and Glutaredoxin Systems in Disulfide Reduction and Thiol Redox Control (2003) (4)
- Photo-labelling of glutaredoxin from Escherichia coli. (1982) (4)
- Catalysts for Car Exhaust: Oxygen Storage in Platinum/Ceria and Mass Transfer in Monoliths (1998) (4)
- Mitochondrial thioredoxin system as a primary target for mercury compounds (2014) (4)
- An improved purification method and a physical characterization of phage T7 DNA polymerase. (2005) (4)
- Reactions of the Thioredoxin System with Selenium (1989) (4)
- Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase (2021) (4)
- Effect of mercury compounds over the redox state of thioredoxin 1 and 2 and its relation with glutathione levels and glutaredoxin activity in human neuroblastoma cells (2015) (4)
- Expression Analysis of the nrdHIEF Operon fromEscherichia coli (2001) (4)
- Thioredoxin expression in human myometrium and fibroids. (2000) (4)
- Enzymatic glutaredoxin-dependent method to determine glutathione and protein S-glutathionylation using fluorescent eosin-glutathione. (2019) (3)
- Expression of ATL-derived factor/human thioredoxin in rejected kidney grafts. (1996) (3)
- cardiovascular system glutaredoxin systems: implications for diseases in the Thiol-based mechanisms of the thioredoxin and (2007) (3)
- Thioredoxin and Glutaredoxin: Functions in Growth-Dependent DNA Synthesis and Cellular Regulation Via Thiol Redox Control (1988) (3)
- Analysis of Glutathione mediated S-(de)nitrosylation in complex biological matrices by immuno-spin trapping and identification of two novel substrates. (2021) (3)
- S‐Denitrosylation by the C‐Terminal Swinging Arm of R1 Subunit: A Novel Mechanism to Restore Ribonucleotide Reductase Activity (2021) (3)
- Thioredoxin and glutaredoxin General aspects and involvement in redox regulation (2001) (3)
- Redox pioneer : Professor (2)
- Resonance assignment and structural analysis of acid denatured E. coli [U-15N]-glutaredoxin 3 (1996) (2)
- Oxidative Modifications of Parkin Underlie its Selective Neuroprotection in Adult Human Brain (2020) (2)
- A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes (2001) (2)
- Ribonucleotide reductase: In-vitro S-glutathionylation of R2 and p53R2 subunits of mammalian class I ribonucleotide reductase protein (2021) (2)
- NMR STRUCTURE OF ESCHERICHIA COLI GLUTAREDOXIN 3-GLUTATHIONE MIXED DISULFIDE COMPLEX, 20 STRUCTURES (1999) (2)
- SULPHATION FACTOR ACTIVITY IN MUSCLE EXTRACT (1969) (1)
- Expression of mRNAs for the Estrogen and Progesterone Receptors, Insulin-like Growth Factor-I and Thioredoxin in the Porcine Cervix (1999) (1)
- Monolith catalysts for car exhaust : experimental and theoretical studies of oxygen storage, flow and mass transfer (1997) (1)
- Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith (2015) (1)
- NMR SOLUTION STRUCTURE OF REDUCED E. COLI GLUTAREDOXIN 2 (2001) (1)
- Chapter 11:Ebselen and Thioredoxin Systems in Human Health, Disease and Therapeutic Potential (2017) (1)
- Redox Signaling and Regulation in Biology and Medicine. Edited by Claus Jacob and Paul G. Winyard. (2010) (1)
- Mechanical Tuning of a Catalytic Cystein PKA in Thioredoxin (2011) (0)
- Folding of human apoSOD: disulphide reduction prevents dimerisation and produces marginally stable monomers (2004) (0)
- Enzymatic reduction of alloxan (0)
- Histopathology vs. inhibition of the thioredoxin system of mercury-exposed fish (2012) (0)
- Chapter 1:Oxidative Folding of Proteins in vivo (2008) (0)
- Ebsulfur: a novel Trypanosoma brucei cytocidal inhibitor targeting the trypanothione metabolism (2012) (0)
- GLUTAREDOXIN 3 FROM ESCHERICHIA COLI IN THE FULLY OXIDIZED FORM (2000) (0)
- Selenium and selenoproteins in health and disease (Forum Editorial) (2010) (0)
- Oxidized thioredoxin reductase from Helicobacter pylori in complex with NADP (2007) (0)
- The Thiol Redox Paradox in the Requirement for Disulfide Isomerization in the Eukaryotic Endoplasmic Reticulum (2003) (0)
- The crystal structure of the protein YhaK from Escherichia coli (2008) (0)
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- Thioredoxin, a redox enzyme released in infection and in inflammation, is a chemotactic factor in vitro and in vivo (1999) (0)
- Mercury and selenium effects on HepG2 cells: TrxR activity and expression levels (2012) (0)
- Interaction between mercury compounds and selenium and its effects on the activity and expression of thioredoxin and thioredoxin reductase in liver cells (2013) (0)
- Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy (2009) (0)
- Hypoxia-Inducible Factor-Alpha (HIF-α) Activation in Non-Hodgkin’s Lymphoma (NHL): Relationship to the Thioredoxin Family and Correlation with Survival by Tissue Microarray (TMA). (2007) (0)
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- 52 EXPERIMENTAL MODEL FOR DEGRADATION OF SOMATOMEDINS (1985) (0)
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- Three-Dimensional Structure ofEscherichia coliThioredoxin-S2 to2.8A Resolution (x-ray protein structure/evolution/electron transport/DNA synthesis) (1975) (0)
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- The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker? (2018) (0)
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- Glutaredoxin 2 and oxidative stress identification of two testis/cancer specific isoforms of human Grx2 in neuro-and medulloblastomas. (2008) (0)
- THIOREDOXIN (OXIDIZED DISULFIDE FORM), NMR, 20 STRUCTURES (1996) (0)
- A multisystem selenoprotein disorder with a thyroid signature (2010) (0)
- Inhibition of the thioredoxin system by PX-12 (1-methylpropyl 2-imidazolyl disulfide) impedes HIV-1 infection in TZM-bl cells (2019) (0)
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- Trx1 is inactivated by Prx1 and reactivated by Grx system (2013) (0)
- Nucleotide sequence of the thioredoxin gene (1984) (0)
- Solution NMR structure of MqsA, a protein from E. coli, containing a Zinc finger, N-terminal and a Helix Turn-Helix C-terminal domain (2011) (0)
- Solution structure of Grx4, a monothiol glutaredoxin from E. coli. (2005) (0)
- Unraveling the Mechanisms of Oxidative Folding using Single Molecule Force Spectroscopy (2011) (0)
- Coenzyme Q10 (CoQ10) in heart muscle and cardiac function in patients treated with adriamycin (1985) (0)
- Helicobacter pylori thioredoxin reductase reduced by sodium dithionite in complex with NADP (2007) (0)
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