Arnold Brossi

Arnold Brossi's AcademicInfluence.com Rankings

Arnold Brossi

Philosophy

#7160

World Rank

#10331

Historical Rank

Ontology

#76

World Rank

#86

Historical Rank

Logic

#4231

World Rank

#5498

Historical Rank

philosophy Degrees

Arnold Brossi

Biology

#9721

World Rank

#12961

Historical Rank

Neuroscience

#1440

World Rank

#1490

Historical Rank

biology Degrees

Download Badge

Philosophy
Biology

Arnold Brossi's Degrees

Doctorate Medicine Stanford University

Why Is Arnold Brossi Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Arnold Brossi's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. (2005) (587)
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism (2009) (504)
The alkaloids : chemistry and pharmacology (1983) (429)
Arteether, a new antimalarial drug: synthesis and antimalarial properties. (1988) (281)
Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease. (1999) (191)
Benzoquinolizine Derivatives: a New Class of Monamine Decreasing Drugs With Psychotropic Action (1962) (163)
Phenserine and ring C hetero‐analogues: Drug candidates for the treatment of Alzheimer's disease (1995) (157)
Identification of Cysteine 354 of β-Tubulin as Part of the Binding Site for the A Ring of Colchicine (*) (1996) (150)
Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone. (1978) (144)
Presence and formation of codeine and morphine in the rat. (1986) (137)
Colchicine and its analogues: Recent findings (1988) (129)
The Nuclear Magnetic Resonance Spectra of the Angular Proton in Benzo[a]- and Indolo[a]quinolizidines (1964) (127)
Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. (1990) (109)
An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. (2005) (106)
Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine. (1990) (103)
Comparative inhibitory effects of various physostigmine analogs against acetyl- and butyrylcholinesterases. (1989) (89)
Alkaloids in mammalian tissues. 2. Synthesis of (+)-and (-)-1-substituted-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines. (1972) (85)
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis. (2000) (81)
Alkaloids in mammalian tissues. 3. Condensations of L-tryptophan and L-5-hydroxytryptophan with formaldehyde and acetaldehyde. (1973) (81)
Antitumor Agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents (2007) (80)
Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354. (2000) (79)
Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity. (2003) (78)
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents. (2006) (78)
Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines. (1981) (77)
Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents. (2004) (75)
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action. (2001) (74)
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. (2007) (67)
Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B (1985) (67)
The chemistry of drugs part IV, Configurations of antimalarials derived from qinghaosu: Dihydroqingyhaosu, artemether, and artesunic acid (1984) (65)
Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. (2006) (62)
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. (2010) (61)
Total Synthesis and Electrophysiological Properties of Natural (−)‐Perhydrohistrionicotoxin, its Unnatural (+)‐Antipode and their 2‐Depentyl Analogs (1982) (59)
The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance. (1993) (55)
Cherylline, a 4-phenyl-1,2,3,4-tetrahydroisoquinoline alkaloid (1970) (55)
Biomimetic total synthesis of (−)-codeine (1983) (52)
Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions. (1979) (52)
Metabolic studies of tetrabenazine, a psychotropic drug in animals and man. (1966) (51)
The importance of the phenyl‐tropolone ‘aS’ configuration in colchicine's binding to tubulin (1988) (47)
N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties. (1990) (46)
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine. (1985) (46)
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents. (1997) (45)
A cellular model of inflammation for identifying TNF-α synthesis inhibitors (2009) (45)
Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase. (1995) (45)
B ring regulation of colchicine binding kinetics and fluorescence. (1986) (45)
Expedient synthesis of racemic and optically active N-norreticuline and N-substituted and 6'-bromo-N-norreticulines (1980) (44)
Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. (2002) (42)
Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents. (2002) (42)
Alkaloids' in mammalian tissues. I. Condensation of L-dopa and its two mono-O-methyl ethers with formaldehyde and acetaldehyde. (1972) (42)
Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent. (2003) (42)
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. (1990) (41)
Structure-activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptor-ion channel complex. (1988) (41)
Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases. (2004) (41)
Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters. (2003) (41)
Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues. (1997) (39)
Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+ (1985) (39)
Synthesis and Absolute Configuration of Cryptostylines I, II, and III (1971) (38)
A simple and practical synthesis of olivetol (1977) (37)
Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid-β Peptide (2006) (35)
Antitumor Agents. Part 184. Syntheses and antitubulin activity of compounds derived from reaction of thiocolchicone with amines: Lactams, alcohols, and ester analogs of allothiocolchicinoids†‡ (1998) (34)
Antitumor Agents. 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids (1998) (34)
Synthesen in der Isochinolinreihe Halogensubstituierte 1-(ω-Phenylalkyl)-1,2,3,4-tetrahydro-isochinoline als Analgetica (1960) (34)
Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. (2010) (33)
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives. (2005) (33)
Syntheses in the isoquinoline series. Synthesis of 2,3-dihydro-4(1H)-isoquinolones (1968) (33)
aS,7S‐absolute configuration of natural (−)‐colchicine and allocongeners (1990) (33)
Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines. (1983) (33)
Irazepine, a noncompetitive, irreversible inhibitor of 3H-diazepam binding to benzodiazepine receptors (1979) (32)
Chapter 3 Tropolonic Colchicum Alkaloids and Allo Congeners (1992) (31)
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. (2010) (30)
Potential prophylactic antitumor activity of retinylidene 1,3-diketones. (1980) (30)
Pharmacologic activity of stereoisomers of 1-substituted 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines: inhibition of 3H-dopamine accumulation by rat brain slices and lipolytic activity with isolated mouse fat cells. (1974) (30)
Fragmentation of Optically Active (1‐Phenylethyl)‐ and (1‐Naphthylethyl)ureas in Refluxing Alcohols: Easy Preparation of Optically Active Amines of High Optical Purity (1986) (30)
Practical synthesis of unnatural (+)-physostigmine and carbamate analogues (1988) (29)
A New Synthesis of "Schöpf's Base VI" and Related 10H-Isoindolo[2,3-c] benzazepines (1972) (29)
Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs. (1984) (29)
Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. (1985) (29)
Colchicine binding to antibodies. (1980) (28)
Inhibition of acetylcholinesterase from electric eel by (−)‐ and (+)‐physostigmine and related compounds (1986) (28)
Antimalarial activity and inhibition of monoamine oxidases A and B by exo‐erythrocytic antimalarials (1987) (27)
Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+ (2005) (27)
Conversion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) and its 5-methyl analog into pyridinium salts† (1984) (26)
Enantiomer (+)physostigmine prevents organophosphate‐induced subjunctional damage at the neuromuscular synapse by a mechanism not related to cholinesterase carbamylation (1988) (26)
The synthesis of tetrahydroisoquinolines from 1,4-dihydro-3 (2H)-isoquinolones (1967) (26)
Colchicine Models: Synthesis and Binding to Tubulin of Tertamethoxybiphenyls (1988) (26)
Nitroimidazoles II. synthesis and reactions of iodonitroimidazoles (1966) (25)
Syntheses and anticholinesterase activities of (3aS)-N1, N8-bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine. (1998) (25)
Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties (1996) (25)
Synthesis of cherylline (1970) (24)
The Molecular Basis of Anticholinesterase Actions on Nicotinic and Glutamatergic Synapses a (1987) (24)
Fluorinated colchicinoids: antitubulin and cytotoxic properties. (1991) (24)
Preparation and Characterization of Tetrabenazine Enantiomers against Vesicular Monoamine Transporter 2. (2010) (24)
Further insight into the mode of action of the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) (1985) (24)
A novel synthesis of colchicide and analogues from thiocolchicine and congeners: reevaluation of colchicide as a potential antitumor agent. (1987) (24)
Conversion of natural phthalideisoquinolines into benzazepine alkaloids. (1971) (23)
Facile conversion of natural colchicine into (.+-.)-congeners and (+)-enantiomers including 2-demethyl analogs (1986) (23)
Selective o-demethylation of ah aromatic methylether in the presence of an aromatic methylenedioxy group with trimethylisilyl iodide in quinoline (1978) (23)
β‐Carbolines from Japanese Sake and Soy Sauce: Synthesis and Biological Activity of Flazin and Yellow Substance YS (Perlolyrine) (1988) (23)
Physovenines: Efficient Synthesis of (−)- and (+)-Physovenine and Synthesis of Carbarnate Analogues of (−)-Physovenine. Anticholinesterase Activity and Analgesic Properties of Optically Active Physovenines† (1991) (22)
An improved synthesis of various racemic polyphenolic tetrahydroisoquinoline alkaloids (1968) (22)
Selective O-demethylation of papaverine. (1970) (22)
Comparison of mass spectral techniques using organic peroxides related to artemisinin. (1990) (22)
Rac. cis‐ und trans‐ 1, 2‐Dimethyl‐4‐hydroxy‐6, 7‐dimethoxy‐1, 2, 3, 4‐tetrahydro‐isochinolin, Synthese und Stereochemie (1967) (22)
Carbamate analogues of (−)‐physostigmine: In vitro inhibition of acetyl‐ and butyrylcholinesterase (1988) (22)
Syntheses in the isoquinoline series. Synthesis and chemical transformation of 2,3-dihydro-4(1H)-isoquinolones (1968) (22)
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors. (1998) (21)
Activation and Blockade of the Nicotinic and Glutamatergic Synapses by Reversible and Irreversible Cholinesterase Inhibitors (1987) (21)
Natural products. Antitubulin effect of congeners of N-acetylcolchinyl methyl ether: synthesis of optically active 5-acetamidodeaminocolchinyl methyl ether and of demethoxy analogues of deaminocolchinyl methyl ether (1992) (21)
The Partial O‐Demethylation of Aromatic‐Substituted 3,4‐Dihydroisoquinolines (1970) (21)
Progress towards a practical total synthesis of Calabar alkaloids: total synthesis of (−)-esermethole and (−)-physovenol methyl ether from (3S)-1,3-dimethyl-3-carboxymethyl-5-methoxyoxindole (1993) (21)
Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues. (2000) (21)
Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis. (1997) (21)
PAVINAN AND ISOPAVINAN ALKALOIDS. SYNTHESIS OF RACEMIC AND NATURAL THALIDINE, BISNORARGEMONINE, AND CONGENERS FROM N-NORRETICULINE (1980) (21)
The chemistry of drugs. VI: Thermal decomposition of qinghaosu (1985) (21)
Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity. (2011) (20)
13C‐ and 1H‐NMR. Assignments for colchicine derivatives (1980) (20)
Deaminocolchinyl Methyl Ether: Synthesis from 2,3,4,4′‐Tetramethoxybiphenyl‐2‐carbaldehyde. Comparison of antitubulin effects of deaminocolchinyl methyl ether and dehydro analogs (1989) (20)
Probes for a Regulatory Site on the Nicotinic Acetylcholine Receptor‐Channel. Synthesis of (±)‐7‐Debutylperhydrohistrionicotoxin, (±)‐2‐Depentyl‐7‐debutylperhydrohistrionicotoxin, and their Analogues (1985) (19)
Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines. (1980) (19)
Synthesis of (±)‐trans‐2,5‐Dialkylpyrrolidines from the Lukes‐Šorm Dilactam: Efficient Preparation of (±)‐trans‐2‐Butyl‐5‐heptylpyrrolidine and Analogs Present in Ant Venoms (1987) (19)
Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential. (2004) (19)
Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents. (2010) (19)
Conversion of (-)-.beta.-hydrastine into (-)-bicuculline and related phthalideisoquinolines (1972) (19)
Mammalian Alkaloids: O‐Methylation of (±)‐Norcoclaurine‐1‐carboxylic Acid and Related Isoquinolines Including (S)‐ and (R)‐Norcoclaurine with 14C‐Labeled S‐Adenosyl‐L‐Methionine in Presence of Mammalian Catechol O‐Methyltransferase (1990) (18)
Chapter 1 Tropolonic Colchicum Alkaloids (1984) (18)
Nitrohistidines and nitrohistamines. (1973) (18)
Synthesen in der Isochinolinreihe Zur Konfiguration von (−)-1-(p-Chlorphenäthyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isochinolin (1961) (18)
Alkaloids in mammalian tissues. 4. Synthesis of (+)- and (-)-salsoline and isosalsoline. (1974) (17)
Synthesis of hormothamnione (1988) (17)
Selective demethylation of 3,4-dimethoxy-substituted aromatic aldehydes and ketones (1967) (17)
Effects of mescaline and some of its analogs on cholinergic neuromuscular transmission (1993) (17)
Antitumor agents 238. anti-tubulin and in vitro cytotoxic effects of N-substituted allocolchicinoids (2005) (17)
Selective ther cleavage in the aporphine series. Conversion of (S)-bulbocapnine into (S)-corytuberine and (S)-corydine methyl ether. (1976) (16)
Further explorations of unnatural alkaloids. (1985) (16)
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. (2005) (16)
Chemistry of colchine (1991) (16)
Preferential cleavage of an aromatic methylenedioxy group in the presence of methoxyls with boron trichloride (1972) (15)
Synthesis and anticholinesterase activity of (-)-N1-norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine. (1988) (15)
(+/-)-2-Depentylperhydrohistrionicotoxin: a new probe for a regulatory site on the nicotinic acetylcholine receptor-channel. (1982) (15)
Colchicine analogues: Effect on amyloidogenesis in a murine model and, in vitro, on polymorphonuclear leukocytes (1992) (15)
Synthesis of (−)- and (+)-2-hydroxy-6-keto-N-methylmorphinans, their O-methyl ethers, and 2-deoxy congeners (1982) (15)
Enzymatic Oxidative Coupling of optically Active Laudanosoline and Its Methiodide (1973) (15)
An improved synthesis of diaveridine, trimethoprim, and closely related 2,4-diaminopyrimidines. (1971) (15)
Improvements in the total synthesis of physostigmine: reductive cyclization of oxindoles to tricyclic indoleninepyrrolidines with lithium aluminium hydride in tetrahydrofuran (1988) (15)
A total synthesis of the alkaloid rhoeadine. Preliminary communication. (1971) (15)
Simple Conversion of Colchicine into Demecolcine (1979) (15)
The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14-unit T-maze (1992) (14)
Synthesis of (±)-physovenine and (±)-7-bromophysovenine from intermediates of the synthesis of physostigmines (1990) (14)
Mapping the Binding Site of Colchicinoids on β-Tubulin (2000) (14)
Designing Drugs for Optimal Nervous System Activity (1995) (14)
Mammalian Alkaloids: Conversions of Tetrahydroisoquinoline-1-carboxylic Acids Derived from Dopamine*. (1991) (14)
Synthesis and chemotherapeutic activity of two metabolites of trimethoprim. (1971) (14)
Mammalian alkaloids : synthesis and O-methylation of (S)- and (R)-3'-hydroxycoclaurine and their N-methylated analogues with S-adenosyl-L-[methyl-14C]methionine in presence of mammalian catechol O-methyltransferase (1991) (14)
Some recent results on the chemotherapy of amebiasis, coccidiosis, and malaria (1969) (13)
Monophenolic 1,2,3,4-tetrahydroisoquinolines and their methyl (1971) (13)
Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides. (2005) (13)
Preparation of R(+)- and S(-)-α-Methyl-p-nitrobenzylamines and Their Use as Resolving Agents (1977) (13)
Total Synthesis of (±)‐3‐Deoxy‐7,8‐dihydromorphine. Preliminary Communication (1980) (13)
Asymmetric solid-phase synthesis of (3'R,4'R)-di-O-cis-acyl 3-carboxyl khellactones. (1999) (13)
(−)-4-Hydroxy-N-formylmorphinan-6-one, a versatile intermediate for the synthesis of 3-deoxyopioids (1980) (13)
Esters of 1‐O‐Demethylthiocolchicines: Formation of Isomers in Chloroform Solution (1985) (13)
Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease? (2006) (13)
Optically active tetrahydro-.alpha.-phenyl-6,7-dimethoxyisoquinoline-1-methanols from (1-phenylethyl)ureas. Absolute configuration of (-)- and (+)-isomers of the erythro series (1989) (13)
Antitumor Agents. 192. Antitubulin Effect and Cytotoxicity of C(7)-Oxygenated Allocolchicinoids (1999) (13)
Mammalian Alkaloids: Configurations of Optically Active Salsoline- and 3′,4′-Dideoxynorlaudanosoline-1-carboxylic Acids† (1987) (13)
Reactions of (-)-Physositigmine and (-)-N-Methyphysostigmine in Refluxing Butanol and at High Temperature: Facile Preparation of (-)-Eseroline (1987) (12)
Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. (1979) (12)
A novel synthesis of aromatic methoxy and methylenedioxy substituted 2,3,4,5‐tetrahydro‐1H‐3‐benzazepines (1972) (12)
MPTP metabolites inhibit rat brain glutathione S-transferases (1987) (12)
Structure‐Activity Relationships of Oxygenated Morphinans. I. 4‐Mono‐ and 3,4‐dimethoxy‐N‐methylmorphinans and ‐N‐methyl‐morphinan‐6‐ones with unusually high antinociceptive potency. Preliminary communication (1981) (12)
Geneserine and geneseroline revisited: acid-base catalyzed equilibria of hexahydropyrrolo-[2,3-b]-indole N-oxides with hexahydro-1,2-oxazino-[5,6-b]-indoles. (1989) (12)
Total synthesis of racemic cherylline (1970) (12)
The synthesis of some 7- and 7,8-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines (1971) (12)
Total Synthesis of Racemic and Optically Active Compounds Related to Physostigmine and Ring‐C Heteroanalogues from 3‐[2′‐(dimethylamino)ethyl]2,3‐dihydro‐5‐methoxy‐1,3‐dimethyl‐1H‐indo l‐2‐ol (1994) (12)
Racemic N1-norphenserine and its enantiomers: Unpredicted inhibition of human acetyl- and butyrylcholinesterase and β-amyloid precursor protein in vitro (2003) (12)
PRACTICAL TOTAL SYNTHESES OF PHYSOSTIGMINES AND OF PHENSERINES : A SYNOPSIS (1996) (11)
Selective ether-cleavage of thiocolchicoside and thiocolchicine: characterization of 3- and 2-demethylthiocolchicine and catecholic congeners (1983) (11)
Synthesis in the emetine series—XIV (1968) (11)
Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze (2005) (11)
A Novel Synthesis of Aporphines via 3-Phenylphenethylamines† (1979) (11)
Interaction of monoamine oxidase B with analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine derived from prodine-type analgesics. (1986) (11)
Antimalarial activity of natural, racemic and unnatural dihydroquinine, dihydroquinidine and their various racemic analogs in mice infected withPlasmodium berghei (1971) (11)
Total synthesis of pentaline (1968) (11)
Synthesis in the Emetine Series. XIII.1 Structure and Synthesis of Psychotrine and 6'-O-Methyl-7'-desmethylpsychotrine (1966) (11)
Antitumor agents 248. Chemistry and antitumor activity of tylophorinerelated alkaloids (2008) (11)
Structure-Activity Relationship of Oxygenated Morphinans. V. Narcotic agonist and antagonist activity in the 14-hydroxymorphinan series. Preliminary communication (1981) (11)
Synthesis of (-)-1-hydroxy-N-methylmorphinan-6-one and its O-methyl ether from (-)-4-hydroxy-N-formylmorphinan-6-one (1983) (11)
New synthesis and absolute configuration of tetrahydroisoquinoline cactus alkaloids (1971) (10)
Syntheses and Biological Evaluation of (±)-3a-Phenyl Congeners of Physostigmine and Phenserine (1998) (10)
Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. (1987) (10)
METABOLIC STUDIES OF VERSIDYNE, A NEW ANALGESIC, IN THE RABBIT AND IN MAN. (1964) (10)
Synthesis of two aromatic methylenedioxy-substituted colchicine congeners: elucidation of the structure of cornigerine as 2,3-(methylenedioxy)-2,3-didemethoxycolchicine (1981) (10)
Absolute configuration of cryptostylines I, II, and III by x-ray analysis and aromatic chirality method (1973) (10)
The ionic channel of the nicotinic acetylcholine receptor is unable to differentiate between the optical antipodes of perhydrohistrionicotoxin (1983) (10)
Fifteen years of research of bioactive alkaloids (1992) (10)
Oxidation Products of Phenolic Thiocolchicines: Ring a Quinones and Dienones (1998) (10)
Syntheses in the isoquinoline series. Selective demethylation of 6,7- and 7,8-dimethoxy-2,3-dihydro-4(1H)-isoquinolones (1968) (10)
Structure‐Activity Relationship of Oxygenated Morphinans. VII. 5‐Methylated and 14‐Hydroxy‐substituted Agonists and Antagonists of the 4‐Hydroxy‐ and 3, 4‐Dioxygenated 6‐Morphinanone Series (1982) (10)
Colchicine models: Synthesis and Antitubulin Activity of 2′‐Monosubstituted and 2′, 5‐Disubstituted 2,3,4,4′‐Tetramethoxy‐1,1′‐biphenyls. Synthesis of 4,4′, 5′, 6′‐tetramethoxy‐1,1′‐biphenyl‐2,3′‐dicarboxylic acid (1989) (10)
Chloroacetates of 2- and 3-demethylthiocolchicine: specific covalent interactions with tubulin with preferential labeling of the beta-subunit. (1992) (10)
Mammalian Alkaloids: O‐methylation of (S)‐ and (R)‐dideoxynorlaudanosoline‐1‐carboxylic acid by catechol O‐methyltransferase and identification of a yellow pigment obtained at physiological pH (1988) (10)
Antihistomonal activity of ipronidazole and closely related nitroimidazoles. (1971) (10)
Alkaloids in the mammalian system. (1974) (10)
Synthesis and binding to tubulin of colchicine spin probes. (1984) (10)
Preparation of Optically Active Secondary Amines by Thermal Decomposition of (Methylbenzyl)urea Analogs: Absolute Configuration of (+)‐ and (−)‐Mecamylamine. Preliminary Communication (1986) (9)
3'-Methyl, 8-methyl, and 8-phenyl derivatives of 5,9-dimethyl-6,7-benzomorphans. (1970) (9)
Iodinated 5- and 8-hydroxyisoquinolines as potential amebicides. (1966) (9)
Comparison of (-)-eseroline with (+)-eseroline and dihydroseco analogues in antinociceptive assays: confirmation of rubreserine structure by X-ray analysis. (1986) (9)
R-(+)- and S-(-)-tetrahydroharmine : preparation of optically pure alkaloids and acid-catalyzed racemization (1990) (9)
Detection of metabolites of qinghaosu in nanomolar quantities: DADF-esters of dihydroqinghaosu and its epoxy analog. The chemistry of drugs. V (1984) (9)
DI-(2,2,2-Trichloroethyl)-Carbonate: Byproduct in Reactions with 2,2,2-Trichloroethyl Chloroformate (1990) (9)
Chiral drugs: Synopsis (1994) (9)
Axial Configuration of Optically Active Colchicinoids and Allocolchicinoids: A Correction (1999) (9)
The oxidation of thebaine with m-chloroperbenzoic acid. Studies in the (+)-morphinan series. III. (1977) (8)
C-(11)-epi-deoxyarteether: formation and structure (1988) (8)
Phenylcarbamates of (-)-Eseroline, (-)-N1-Noreseroline and (-)- Physovenol: Selective Inhibitors of Acetyl and/or Butyrylcholinesterase. (1993) (8)
Total Synthesis of (±)‐3‐Deoxy‐7,8‐dihydromorphine, (±)‐4‐Methoxy‐N‐methylmorphinan‐6‐one and 2,4‐Dioxygenated (±)‐Congeners (1982) (8)
7‐Oxo‐deacetamidocolchiceine and 7‐Benzylimino‐deacetamido‐colchiceine: Two novel products from the base catalysed reaction of (−)‐N‐Benzylidene‐deacetylcolchiceine (1978) (8)
Retro-Aldol Reaction of Retinylidene-1,3-Diketones; Correlation with Biological Activity (1980) (8)
Expedient Synthesis of (S)- and (R)-Norcoclaurine from (S)- and (R)-Armepavine Prepared by the 1-Phenylethylurea Method (1990) (8)
Mammalian TIQ's: products of condensation with aldehydes or pyruvic acids? (1982) (8)
Precursors of the mammalian synthesis of morphine: (+)‐salutaridine and (−)‐thebaine from (+)‐6‐demethylsalutaridine, and (−)‐N‐13CH3‐thebaine from (−)‐northebaine (1986) (8)
Selective O-demethylation of isoquinoline alkaloids: Preparation of hydrocotarnoline from hydrocotarnine and conversion of S-(+)-laureline into S-(+)-roemerine via S-(+)-mecambroline (1979) (7)
Preparation and biological properties of (-)- and (+)-6-hydroxydopa (1970) (7)
Revision of the Structure of ‘Epoxycolchicine’ (1980) (7)
Reduction of Phenyl-Substituted Pyridinium Methoiodides with Sodium Borohydride. Formation of Amine-Borane Complexes in Water (1985) (7)
Chapter 3 Biological Activity of Unnatural Alkaloid Enantiomers**This paper is dedicated to Professor Dr. Vladimir Prelog from the Laboratorium for Org. Chemie. ETH-Zentrum, Zürich. Switzerland, on the occasion of his 90th birthday. (1998) (7)
anti‐HIV Agents. Part 55. 3′R,4′R‐Di‐(O)‐(‐)‐camphanoyl‐2′,2′‐dimethyldihydropyrano [2,3‐f]chromone (DCP), a Novel anti‐HIV Agent. (2003) (7)
Thiocolchicinethiones: Acid Hydrolysis of Natural and Iso-Isomers (1990) (7)
4'-HYDROXYPHENYLCARBAMATES OF (3AS)-ESEROLINE AND (3AS)-N(1)-NORESEROLINE : POTENTIAL METABOLITES OF THE ALZHEIMER'S ANTICHOLINESTERASE DRUG PHENSERIN E (1999) (7)
The structure and absolute configuration of (−)-templetine (1974) (7)
Antitumor Agents. Part 236. Synthesis of Water-Soluble Colchicine Derivatives (2005) (7)
Structure Determination of Brominated Morphinan‐6‐ones by 13C‐NMR. Spectroscopy: A novel closure of the oxygen bridge using 4‐acetoxymorphinan‐6‐ones (1981) (7)
The Chemsitry of Drugs. III. Acid Hydrolysis of Antimalarial 5-Alkoxy-6,6-dimethyl-5,6-dihydro-s-triazines (1983) (7)
Synthesis in the Emetine Series XV1) Friedel-Crafts Acylation of N-Acetylhomoveratrylamine: A Facile Synthesis of 9,10-Dimethoxybenzo[a]Quinolizidine (1972) (7)
STRUCTURE, CHEMISTRY, AND ANTIMALARIAL PROPERTIES OF MEFLOQUINE-AZIRIDINE (1981) (7)
Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (speciocolchine). (1990) (7)
(E)-5-Hydroxypyrrolizidin-3-one: versatile synthon for the synthesis of 5-substituted 2-pyrrolidones and (Z)-3-alkylpyrrolizidines (1982) (7)
Syntheses of various 2,5‐disubstituted oxazole derivatives related to natural products (1965) (7)
Antitumor Agents. Part 209. Pheophorbide-a Derivatives as Photo-Independent Cytotoxic Agents. (2002) (7)
Synthesis of colchifoline from deacetylcolchiceine (1981) (7)
Synthesis of 1,2,3,4-tetrahydro-1,1,2,3,3,4,4-heptamethyl-6,7-dimethoxyisoquinoline and related compounds as potential hypotensive agents. (1971) (7)
Reaction of alcohols and amines with diacetyldihydrofluorescein (DADF): conversion into erythrosine-derivatives on TLC-plates by ammonia and iodine vapors (1984) (7)
A practical conversion of natural physostigmine into the potent butyrylcholinesterase inhibitor N1,N8-bisnorcymserine (2000) (7)
175 Years of Isoquinoline Drugs (1978) (7)
Aromatization of 1-Benzyltetrahydroisoquinolines: Racemization of (−)-(S)-(N-nor)-Reticuline† (1981) (7)
A Simple One-Pot Synthesis of Benzoxazine-2,4-diones and Benzothiazine-2,4-diones (2003) (6)
New approaches on the synthesis of isoquinoline derivatives related with natural products. (1966) (6)
PARTIAL SYNTHESIS OF 3‐DEOXYDIHYDROMORPHINE FROM (‐)‐4‐HYDROXY‐6‐KETO‐N‐METHYLMORPHINAN (1979) (6)
Syntheses of Aromatic Substituted 6′‐Thiothalidomides. (2009) (6)
The Formation of Alkaloids in Mammalian Tissues (1975) (6)
The Conversion of Isoindolobenzazepines into Dibenzazecines: A new Synthesis of α‐Allocryptopine from Schöpf's Base VI (1973) (6)
(S)-1,3-Dimethyl-3-hydroxy-5-methoxyoxindole: By-product in the synthesis of physostigmine (1993) (6)
FACILE PREPARATION OF (3S)-1,3-DIMETHYL-3-CYANOMETHYL-5-ETHOXYOXINDOLE FROM JULIAN'S NITRILE ENRICHED IN THE (3S)-ENANTIOMER (1995) (6)
The Chemistry and Pharmacology of Morphinan Alkaloids (1985) (6)
Chemistry of colchicine. (1991) (5)
Morphinans and 6-Ketomorphinans Unsubstituted in the Aromatic Ring. High Analgesic Activity of (-)-6-Keto-N-methylmorphinan. Part 4. (1982) (5)
DEOXYMORPHINES: ROLE OF THE PHENOLIC HYDROXYL IN ANTINOCICEPTION AND OPIATE RECEPTOR INTERACTIONS (1979) (5)
Antitumor Agents. Part 226. Synthesis and Cytotoxicity of 2‐Phenyl‐4‐quinolone Acetic Acids and Their Esters (2003) (5)
STUDIES IN THE (+)-MORPHINAN SERIES. 5. SYNTHESIS AND BIOLOGICAL PROPERTIES OF (+)-NALOXONE (1978) (5)
Conversion of Natural (S)-Bulbocapnine into Two (Ring A)-Substituted Derivatives of (R)-Apomorphine† (1979) (5)
Spectroscopic, optical and crystallographic properties of (S)-(+)-cis-6'-bromo-N-formylnorreticuline (1982) (5)
Preferential cleavage of trimethoxy-substituted 1,2,3,4-tetrahydroisoquinoline alkaloids (1970) (5)
A concise regiospecific synthesis of 8,8-dimethyl-2H, 8H-pyrano[6, 5-h]quinolin-2-oneand related compounds (1999) (5)
Thiaphysovenol phenylcarbamates: X-ray structures of biologically active and inactive anticholinesterase agents (1993) (5)
Syntheses of Aromatic Substituted6′-Thiothalidomides (2008) (5)
A practical synthesis of protostephanine. (1967) (5)
Alkaloids: chemistry and pharmacology. Volume 45. (1994) (5)
[Hydroxymorphinans. 6. Paper chromatography of morphinan derivatives and their excretion in urine]. (1955) (5)
Direct and Sequential Removal of Phenolic Oxygen Functions in S-(+)-Bulbocapnine, S-(+)-Boldine and R-(-)-Apomorphine (1977) (5)
Phenolic congeners of colchicine: preparation and characterization of phenolic and catecholic analogues of colchicine, colchiceine and thiocolchicine (1989) (5)
Studies in the (+)-Morphinan Series VI. Dimers of Natural (—)- and Unnatural (+)-Sinomenine (1978) (5)
Synthesis of 3-Alkylidene-isoindolinones via Sulphide Contraction (2004) (5)
A total synthesis of racemic petaline (1966) (5)
BIOLOGICAL EFFECTS OF MODIFIED COLCHICINES. IMPROVED PREPARATION OF 2-DEMETHYLCOLCHICINE, 3-DEMETHYLCOLCHICINE, AND (+)-COLCHICINE AND REASSIGNMENT OF THE POSITION OF THE DOUBLE BOND IN DEHYDRO-7-DEACETAMIDOCOLCHICINES (1981) (4)
Recent developments in colchicum alkaloids (1983) (4)
A simplified synthesis of (.+-.)-4-hydroxy-N-methylmorphinan-6-one (1982) (4)
THE PRESENT STATUS OF MALARIA CHEMOTHERAPY (1976) (4)
Aromatie‐substituted derivatives of 2,3,4,5‐tetrahydro‐7,8‐methylenedioxy‐1H‐3‐benzazepine. Syntheses via chloromethylation (1972) (4)
Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase (1986) (4)
727. Chemical constitution and amœbicidal action. Part V. Stereochemistry of emetine (1959) (4)
Synthesis of 14C labelled electrophilic ligands of the colchicine binding site of tubulin: Chloroacetates of demethylthiocolchicines and of N‐acetylcolchinol; isothiocyanate of 9‐deoxy‐N‐acetylcolchinol (1993) (4)
TETRAMETHOPRIM and PENTAMETHOPRIM: Synthesis, Antibacterial Properties and X‐Ray Structures (1983) (4)
The synthesis and biological properties of some dibenzazepines and dibenzazonines related to protostephanine. (1969) (4)
Improved Synthesis of the Lukes-ŜOrm Dilactam. Nucleophilic Opening to 5-Substituted 2-Pyrrolidine-2-Ones (1988) (4)
Thiaphysovenine and carbamate analogues: a new class of potent inhibitor of cholinesterases (1992) (4)
Synthesis of 6'-methylated reticulines and tetrahydropapaverolines (1983) (4)
Separation of Dopamine and Dopamine-Related Tetrahydroisoquinolines by Reversed-Phase Liquid Chromatography, Reversed-Phase Ion-Pair Chromatography, and Ion-Exchange Chromatography (1983) (4)
Antitumor Agents. Part 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids. (1998) (4)
Synthesis and biological properties of 1-dimethylamino-3-methyl-3-(3-hydroxyphenyl)butane, a potential analgetic. (1968) (4)
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. (2002) (4)
Reaction of colchiceinamide with phosgene and with thiophosgene : structures and antitubulin activity of tetracyclic oxazolones, oxazolethiones and thiazolones of the colchicine series (1990) (4)
Absolute configuration of deglucopterocereine: conversion into R-(+)-N-methylcalycotomine. (1985) (4)
CHIRAL PRODYES. ETHERS AND ESTERS OF DIHYDROFLUORESCEIN. I, DIBENZYLDIHYDROFLUORESCEIN (DBDF) A NEW REAGENT (1990) (4)
A study of the novel synthetic analog (+/-)-depentylperhydrohistrionicotoxin on the nicotinic receptor-ion channel complex. (1984) (4)
Oxidation Products of Retinylidene Dimedone (1980) (4)
Tris-N, N'N″-(3',4',5'-trimethoxyphenethyl)-1,3,5-hexahydrotriazine, a methylenemescaline trimer: characterization and selective cyclization to anhalinine under non-aqueous conditions (1989) (4)
Structure Activity Relationship in the Colchicine Molecule with Respect to Interaction with the Mammalian Multidrug Transporter, P-Glycoprotein (1994) (4)
1,2-Dehydroreticuline : conversion of iminium salts into enamines (1993) (4)
Bioactive Alkaloids. Part 4. Results of Recent Investigations with Colchicine and Physostigmine (1991) (4)
Novel (±)-1-phenyltetrahydroisoquinolines and 1-phenylisoquinolines: potential intermediates in alkaloid synthesis (1987) (4)
BIOLOGICAL EFFECTS OF MODIFIED COLCHICINES. 2. EVALUATION OF CATECHOLIC COLCHICINES, COLCHIFOLINES, COLCHICIDE, AND NOVEL N-ACYL- AND N-AROYLDEACETYLCOLCHICINES (1984) (3)
Direct Conversion of S-(+)-Bulbocapnine into S-(+)-2-Hydroxy-10-methoxyaporphine (1978) (3)
8-Methxlcorxpallihe and its O-Metbzlzzher: A Facile Sxhthesis of 8-Methxl Substituted-6, 7- Dimethoxy Tetrahsdroisoquxnolines (1972) (3)
Antimalarial activity of racemic 3-Epidihydroquinine, 3-Epidihydroquinidine and their various racemic analogs in mice infected withPlasmodium berghei (1973) (3)
Structure of an ether dimer of deoxydihydroqinghaosu, a potential metabolite of the antimalarial arteether. (1989) (3)
PREPARATION AND ANALGESIC ACTIVITY OF SOME 3,4-DISUBSTITUTED N-METHYLMORPHINANS OF THE (-) SERIES (1977) (3)
1-Oxotetrahydro-2-benzazepines from 1-Methyl-3,4-dihydro-5H-2-benzazepines: Synthesis of N-Methyl-7,8,9-trimethoxy-2,3,4,5-tetrahydro-1H-2-benzazepine (1987) (3)
Synthesis of 7-Methoxy-1,2,3,4-tetrahydro-5-isoquinolinol (1970) (3)
Interaction of analogs of histrionicotoxin with the acetylcholine receptor ionic channel complex and membrane excitability. (1984) (3)
Synthesis of 5-alkylpyrrolizidin-3-ones from the Lukes-Šorm lactam by Grignard reaction and recyclization of intermediate 5-bromoalkylpyrrolidin-2-ones (1988) (3)
Minor Alkaloids in Commercial Samples of Colchicine (1980) (3)
Formation of blue diquinolinyl methine dyes by irradiation of N-acylated primaquine in chloroform solution with ultraviolet light (1986) (3)
Ellipticine derivatives. (1975) (3)
4-Hydroxy-1,2,3,4-tetrahydroisoquinolines: potential reaction products of norepinephrine1,2. (1980) (3)
STRUCTURE-ACTIVITY RELATIONSHIPS OF OXYGENATED MORPHINANS. II. SYNTHESIS AND BIOLOGICAL PROPERTIES OF 4-METHOXYMORPHINAN-6-ONES WITH NARCOTIC ANTAGONIST SIDE-CHAINS ON NITROGEN (1981) (3)
Chapter 2 Mammalian Alkaloids II (1993) (3)
Alkaloids of Templetonia retusa. Chemistry, Structure and Absolute Configuration of (-)-Templetine (1991) (3)
Apomorphinans from Isoquinolines: Grewe cyclization of 1‐(2‐hydroxybenzyl)‐N‐methyloctahydroisoquinoline and its O‐methyl ether (1983) (3)
Physovenines: Efficient Synthesis of (‐)‐ and (+)‐Physovenine and Synthesis of Carbamate Analogues of (‐)‐Physovenine. Anticholinesterase Activity and Analgesic Properties of Optically Active Physovenines. (1991) (3)
Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors. (1998) (3)
STUDIES IN THE (+)-MORPHINAN SERIES. 7. UNUSUAL CRYSTALLOGRAPHIC AND TAUTOMERIC PROPERTIES OF (+)-4-HYDROXY-7-OXO-3-METHOXY-17-METHYL-5,6-DEHYDROMORPHINAN: AN INTERLACING DOUBLE HELIX (1980) (3)
A Practical Conversion of Natural Physostigmine into the Potent Butyrylcholinesterase Inhibitor N1,N8-Bisnorcymserine. (2000) (3)
Chiral prodyes : synthesis and full characterization of (S)-1-phenylterhylamides of the optically active O-methyldihydrofluoresceins (1991) (3)
Remarkable progress towards a practical synthesis of codeine Discovery of novel and highly active morphinan analgesics (1982) (3)
CHARACTERIZATION AND ANTIMALARIAL ACTIVITY OF FOUR ACETYLATED PYRIMETHAMINES (1980) (2)
THE CHEMISTRY OF DRUGS. PART IV. CONFIGURATIONS OF ANTIMALARIALS DERIVED FROM M QINGHAOSU: DIHYDROQINGHAOSU, ARTEMETHER, AND ARTESUNIC ACID (1984) (2)
L-DOPA: chemical modifications and biological evaluation. (1974) (2)
CONVERSION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) AND ITS 5-METHYL ANALOG INTO PYRIDINIUM SALTS (1985) (2)
Synthesis and Biological Effects of Novel Thiocolchicines. Part 3. Evaluation of N-Acyldeacetylthiocolchicines, N-(Alkoxycarbonyl)deacetylthiocolchicines and O-Ethyldemethylthiocolchicines. New Synthesis of Thiodemecolcine and Antileu (1985) (2)
2‐Hydroxybenzoic acid salt of physostigmine (2002) (2)
Bis-(Tetrahydroxy-dibenz[b,g]indolizine) by Air Oxidation of Tetrahydropapaveroline (1979) (2)
Synthesis and tubulin interaction of thiocolchicines containing an isothiocyanato group. Synthesis of C(2)-deuterated and C(2)-14C-labeled 7-isothiocyanatodeacetamidothiocolchicine (1991) (2)
Stereocontrolled Conversion of 3,5-Dioxopyrrolizidine Into (Z)- and (E)- 5-Acetonylpyrrolizidin-3-ones (1989) (2)
Note on Attempts to Prepare Ring‐B Homomorphinan‐6‐ones by Grewe Cyclization from Octahydro‐1‐phenethylisoquinolines (1985) (2)
Acylamidoalkyl Acetophenones from Substituted Phenethylamines: 2-(2-Acetamidoethyl)-4,5-Dimethoxyacetophenone (2003) (2)
Structure and absolute configuration, by several methods, of (S)-2-O-acetyl-2-demethylthiocolchicine (1987) (2)
Reaction of Colchiceinamide with Phosgene and with Thiophosgene: Structures and Antitubulin Activity of Tetracyclic Oxazolones, Oxazolethiones, and Thiazolones of the Colchicine Series. (1991) (2)
Thalidomide-based TNF-inhibitors for neurodegenerative diseases (2004) (2)
Phenserine: A Selective, Long-Acting and Brain-Directed Acetylcholinesterase Inhibitor Affecting Cognition and β-APP Processing (1997) (2)
SYNTHESIS AND BINDING TO TUBULIN OF COLCHICINE SPIN PROBES (1985) (2)
Chapter 3 The Ipecac Alkaloids (1971) (2)
Syntheses and Biological Evaluation of (.+‐.)‐3a‐Phenyl Congeners of Physostigmine and Phenserine. (1999) (2)
Research on Bioactive Natural Products at the NIH (1976-1988) (1988) (2)
N-Dideuterobutyryldeacetylcolchicine: Probes to Study Colchicine Binding Sites on Tubulin Protein (1985) (2)
Preliminary experimental and clinical results with a new synthetic emetine-like compound. (1960) (2)
Structure-activity relationships of oxygenated morphinans. III. An exploration of the effect of the aromatic oxygen and 6-keto group on antinociceptive activity, receptor affinity, and narcotic antagonism. (1982) (2)
Mammalian alkaloids: conversions of tetrahydroisoquinoline-1-carboxylic acids derived from dopamine. (1991) (1)
Reactions of (-)-Physostigmine and (-)-N-Methylphysostigmine in Refluxing Butanol and at High Temperature: Facile Preparation of (-)-Eseroline. (1987) (1)
Synthesis and characterization of 6‐ and 7‐methoxy‐1‐benzyl‐2‐methyl‐1,2,3,4‐tetrahydro‐6‐ and 7‐isoquinolinols (1967) (1)
EXPEDIENT SYNTHESIS OF RACEMIC AND OPTICALLY ACTIVE N-NORRETICULINE AND N-SUBSTITUTED AND 6′-BROMO-N-NORRETICULINES (1980) (1)
N‐demethylation of (±)‐6β‐acetoxy‐3‐tropinone. Synthesis of (±)‐6β‐acetoxynortropane (2009) (1)
Colchicine Models: Synthesis and Binding to Tubulin of Tetramethoxybiphenyls. (1988) (1)
A Simple One‐Pot Synthesis of Benzoxazine‐2,4‐diones and Benzothiazine‐2,4‐diones. (2003) (1)
PARTIAL ETHER CLEAVAGE OF METHOXY AND METHYLENEDIOXY-SUBSTITUTED ISOQUINOLINE ALKALOIDS (1973) (1)
Comparative studies of the release of 1-methyl-4-phenyl-pyridinium species (MPP/sup +/) from rat and mouse brain synaptosomes (1986) (1)
Oxidation Products of Phenolic Thiocolchicines: Ring A Quinones and Dienones. (1998) (1)
Preparation of Optically Active Secondary Amines by Thermal Decomposition of (Methylbenzyl)urea Analogs: Absolute Configuration of (+)‐ and (‐)‐Mecamylamine. (1986) (1)
STRUCTURE-ACTIVITY RELATIONSHIPS OF OXYGENATED MORPHINANS. I. 4-MONO- AND 3,4-DIMETHOXY-N-METHYLMORPHINANS AND -N-METHYLMORPHINAN-6-ONES WITH UNUSUALLY HIGH ANTINOCICEPTIVE POTENCY (1981) (1)
C(9)-Butylated Lactams Related to Perhydrohistrionicotoxin (1988) (1)
(-)-(3aS)-eseroline carbamate, a close analogue of physostigmine. (1997) (1)
Mammalian Alkaloids: O-Methylation of (.+-.)-Norcoclaurine-1-carboxylic Acid and Related Isoquinolines Including (S)- and (R)-Norcoclaurine with 14C-Labeled S-Adenosyl-L-methionine in Presence of Mammalian Catechol O-Methyltransferase (1990) (1)
4′-Hydroxyphenylcarbamates of (3aS)-Eseroline and (3aS)-N(1)-Noreseroline: Potential Metabolites of the Alzheimer′s Anticholinesterase Drug Phenserine. (1999) (1)
Facile Conversion of Natural Colchicine into (.+-.)-Congeners and (+)-Enantiomers Including 2-Demethyl Analogues. (1987) (1)
The rubremetinium and rubremetaminium cations (1966) (1)
Antitumor Agents. Part 172. Synthesis and Biological Evaluation of Novel Deacetamidothiocolchicin‐7‐ols and Ester Analogues as Antitubulin Agents. (1997) (1)
1-Phenethyl-2,3,4,5-tetrahydro-1H-2-benzazepines from 2-acetyl-1-methylene-2,3,4,5-tetrahydro-1H-2-benzazepines (1987) (1)
6,7-Dimethoxy-3-Isochromanone (2003) (1)
Syntheses and Anticholinesterase Activities of Novel 3-Aminocarbonylmethylene-3-methyl-2,3-dihydrobenzofuran-5-yl Carbamates (2007) (1)
Inhibition of platelet aggregation by colchicine, thiocolchicine, and their phenolic and glucosidic congeners (1987) (1)
Structure of (7S)-N-acetyldemecolcine, C23H27NO6 (1985) (1)
REVERSIBLE AND IRREVERSIBLE CHOLINESTERASE INHIBITORS (1987) (1)
POLYMETHOXYLATED ISOQUINOLINES AS POTENTIAL ANTIMITOTIC AGENTS (1978) (1)
SELECTIVE ETHER CLEAVAGE IN THE APORPHINE SERIES. CONVERSION OF (S)-BULBOCAPNINE INTO (S)-CORYTUBERINE AND (S)-CORYDINE METHYL ETHER (1977) (1)
Further Explorations of Unnatural Alkaloids (1986) (0)
(S)‐1,3‐Dimethyl‐3‐hydroxy‐5‐methoxyindole: By‐Product in the Synthesis of Physostigmine. (1994) (0)
24 Preparation of Phenolic Isoquinolines and Phenethylamines by Selective O-Demethylation (1969) (0)
Byproducts in the O-Phenyltetrazolylation of (±)-2,4-Dihydroxy-N-formylmorphinan-6-one. Alkylation at C-5 (1982) (0)
Polymethoxylated Ioquinokines as Potential Antimitotic Agents (1978) (0)
Colchicine Models: Synthesis and Antitubulin Activity of 2′‐Monosubstituted and 2′,5‐Disubstituted 2,3,4,4′‐Tetramethoxy‐1,1′‐biphenyls. Synthesis of 4,4′,5′,6′‐Tetramethoxy‐1,1′‐biphenyl‐2,3′‐dicarboxylic Acid. (1989) (0)
Novel (.+-.)-1-Phenyltetrahydroisoquinolines and 1-Phenylisoquinolines: Potential Intermediates in Alkaloid Synthesis. (1987) (0)
4-DESMETHYL-TRICHOCEREIN (1970) (0)
[On the preparation of substituted 5, 6-dimethyl-pyrimidines starting from 3, 4-dimethyl-5-acylamidoisoxazoles]. (1963) (0)
Phenolic Congeners of Colchicine: Preparation and Characterization of Phenolic and Catecholic Analogues of Colchicine, Colchiceine, and Thiocolchicine. (1989) (0)
Improved Synthesis of (+)-Morphine, (+)-Codeine and (+)-Heroin (1977) (0)
Improved Synthesis of the Lukes-Sorm Dilactam. Nucleophilic Opening to 5-Substituted 2-Pyrrolidin-2-ones. (1988) (0)
3′-METHYL-, 8-METHYL- UND 8-PHENYL-DERIVATE DES 5,9-DIMETHYL-6,7-BENZOMORPHANS (1970) (0)
TOTAL SYNTHESIS OF (.+-.)-3-DEOXY-7,8-DIHYDROMORPHINE, (.+-.)-4-METHOXY-N-METHYLMORPHINAN-6-ONE AND 2,4-DIOXYGENATED (.+-.)-CONGENERS (1982) (0)
[Synthesis and characteristics of various 3-benzazocines, a class of potential analgesics]. (1970) (0)
THE SYNTHESIS OF SOME 9-, 10-, AND 11-MEMBERED RING COMPOUNDS CONTAINING A NITROGEN ATOM, 2,3,4,5,6,7-HEXAHYDRO-1H-3-BENZAZONINES, 1,2,3,4,5,6,7,8-OCTAHYDRO-3-BENZAZOCINES, AND 2,3,4,5,6,7,8,9-OCTAHYDRO-1H-3-BENZAZACYCLOUNDECANES (1973) (0)
Highly selective inhibitors for the treatment and diagnosis of dementia and alzheimer butyrylcholinesterase. (1998) (0)
PROBES FOR A REGULATORY SITE ON THE NICOTINIC ACETYLCHOLINE RECEPTOR-CHANNEL. SYNTHESIS OF (.+-.)-7-DEBUTYLPERHYDROHISTRIONICOTOXIN, (.+-.)-2-DEPENTYL-7-DEBUTYLPERHYDROHISTRIONICOTOXIN, AND THEIR ANALOGS (1985) (0)
SYNTHESIS AND DIHYDROPTERIDINE REDUCTASE INHIBITORY EFFECTS OF POTENTIAL METABOLITES OF THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (1985) (0)
Agents for the diminution of amyloid precursor protein and the treatment of idiocy, and their methods of use (2001) (0)
Chiral Prodyes: Synthesis and Full Characterization of (S)‐1‐ Phenylethylamides of the Optically Active O‐Methyldihydrofluoresceins. (1992) (0)
Transformations of MPTP by ceruloplasmin and peroxidase: comparison with vinca alkaloid biotransformations. (1987) (0)
Syntheses and Anticholinesterase Activities of Novel 3-Aminocarbonylmethylene-3-methyl-2,3-dihydrobenzofuran-5-yl Carbamates. (2008) (0)
Correction. A Simple and Practical Synthesis of Olivetol (1978) (0)
[Configuration and pharmacological action of 1-phenethyl-substituted 1,2,3,4-tetrahydroisoquinolines]. (1964) (0)
P1-356 Novel TNF-alpha inhibitors for neurodegeneration: 3-phthalimidoglutarimide analogues (2004) (0)
SYNTHESIS OF WEBERINE AND NORWEBERINE AND THEIR 1-METHYL CONGENERS (1982) (0)
TOTAL SYNTHESIS AND ELECTROPHYSIOLOGICAL PROPERTIES OF NATURAL (-)-PERHYDROHISTRIONICOTOXIN, ITS UNNATURAL (+)-ANTIPODE AND THEIR 2-DEPENTYL ANALOGS (1982) (0)
REVISION OF THE STRUCTURE OF ′EPOXYCOLCHICINE′ (1980) (0)
THE OXIDATION OF THEBAINE WITH M-CHLOROPERBENZOIC ACID. STUDIES IN THE (.+-.)-MORPHINAN SERIES. III (1978) (0)
[Stereospecificity of the effect of emetine]. (1960) (0)
BIOMIMETIC TOTAL SYNTHESIS OF (-)-CODEINE (1983) (0)
CARBON-13 AND PROTON NMR. ASSIGNMENTS FOR COLCHICINE DERIVATIVES (1980) (0)
Using Phenserine for production of drugs for the treatment of cognitive disorders (1993) (0)
Mammalian Alkaloids: Configurations of Optically Active Salsoline- and 3′,4′-Dideoxynorlaudanosoline-1-carboxylic Acids. (1988) (0)
Mammalian Alkaloids: Synthesis and O-Methylation of (S)- and (R)-3′- Hydroxycoclaurine and Their N-Methylated Analogues with S-Adenosyl-L-( methyl-14C)methionine in Presence of Mammalian Catechol O- Methyltransferase. (1992) (0)
REACTION OF ALCOHOLS AND AMINES WITH DIACETYLDIHYDROFLUORESCEIN (DADF): CONVERSION INTO ERYTHROSINE‐DERIVATIVES ON TLC‐PLATES BY AMMONIA AND IODINE VAPORS (1984) (0)
Antitumor Agents. Part 198. A Concise Regiospecific Synthesis of 8,8‐Dimethyl‐2H,8H‐pyrano[6,5‐h]quinolin‐2‐one and Related Compounds. (1999) (0)
POTENTIAL PROPHYLACTIC ANTITUMOR ACTIVITY OF RETINYLIDENE 1,3-DIKETONES (1980) (0)
SYNTHESIS OF (-)- AND (+)-2-HYDROXY-6-KETO-N-METHYLMORPHINANS, THEIR O-METHYL ETHERS, AND 2-DEOXY CONGENERS (1983) (0)
Anti‐AIDS Agents. Part 41. Synthesis and Anti‐HIV Activity of 3′,4′‐Di‐o‐(‐)‐camphanoyl‐(+)‐cis‐khellactone (DCK) Lactam Analogues. (2000) (0)
A Study of the Novel Synthetic Analog (Plus or Minus)- Depentylperhydrohistrionicotoxin on the Nicotinic Receptor-Ion Channel Complex, (1984) (0)
Reply to comment. De bello physostigminico II (the physostigmine controversy). (1989) (0)
Total Synthesis of Racemic and Optically Active Compounds Related to Physostigmine and Ring-C Heteroanalogues from 3-(2′-(Dimethylamino) ethyl)-2,3-dihydro-5-methoxy-1,3-dimethyl-1H-indol-2-ol. (2010) (0)
Colchicine Analogues in Experimental Murine Amyloidogenesis (1988) (0)
Optically Active Tetrahydro-α-phenyl-6,7-dimethoxyisoquinoline-1-methanols from (1-Phenylethyl)ureas. Absolute Configuration of (-)- and (+)-Isomers of the erythro-Series. (1989) (0)
Probing Receptors with Natural and Synthetic Alkaloids (1984) (0)
The Synthesis of Some 9-,10-, and 11-Membered Ring Compounds Containing a Nitrogen Atom: 2,3,4,5,6,7-Hexahydro-1H-3-Benzazonines, 1,2,3,4,5,6,7,8-Octahydro-3-Benzazocines, and 2,3,4,5,6,7,8,9-Octahydro-1H-3-Benzazacy-cloundecanes (1973) (0)
TOTAL SYNTHESIS OF (.+-.)-3-DEOXY-7,8-DIHYDROMORPHINE. PRELIMINARY COMMUNICATION (1981) (0)
TETRAMETHOPRIM AND PENTAMETHOPRIM: SYNTHESIS, ANTIBACTERIAL PROPERTIES AND X-RAY STRUCTURES (1983) (0)
NOVEL, LONG-ACTING AND SELECTIVE PHYSOSTIGMINE ANALOGUES AS POTENTIAL THERAPEUTICS FOR ALZHEIMER'S DISEASE (1994) (0)
chinolizinen process for the preparation of substituted 2-hydroxy-benzo [a] (1957) (0)
On Attempts to Prepare Ring-B Homomorphinan-6-ones by Grewe Cyclization from Octahydro-1-phenethylisoquinolines. (1986) (0)
Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of dementia and alzheimers disease (1998) (0)
Improvements in the Total Synthesis of Physostigmine: Reductive Cyclization of Oxindoles to Tricyclic Indoleninepyrrolidines with Lithium Aluminum Hydride in Tetrahydrofuran. (1989) (0)
Mammalian Alkaloids: O-Methylation of (S)- and (R)-Dideoxynorlaudanosoline-1-carboxylic Acid by Catechol O-Methyltransferase and Identification of a Yellow Pigment Obtained at Physiological pH. (1989) (0)
Synthesis of 5-Alkylpyrrolizidin-3-ones from the Lukes-Sorm Lactam by Grignard Reaction and Recyclization of Intermediate 5-Bromoalkylpyrrolidin-2-ones. (1989) (0)
′ALKALOIDS′ IN ANIMAL AND HUMAN TISSUES. PART 6. SYNTHESIS AND ABSOLUTE CONFIGURATION OF CHIRAL 2,3,10,11-TETRAHYDROXY-8-METHYLBERBINES (1977) (0)
SYNTHESE VON 7-METHOXY-1,2,3,4-TETRAHYDRO-5-ISOCHINOLINOL (1971) (0)
Additions and Corrections - Paradoxical Effects of N-Cyano-alkyl Substituents upon the Activities of Several Classes of Opioids (1979) (0)
Partial Synthesis of 3-Deoxydihydromorphine from (—)-4-Hydroxy-6-keto-N-methylmorphinan (1979) (0)
Antitumor Agents. Part 215. Antitubulin Effects of Cytotoxic B‐Ring Modified Allocolchicinoids. (2003) (0)
ALKALOIDS IN MAMMALIAN TISSUES PART 4, SYNTHESIS OF (+)- AND (-)-SALSOLINE AND ISOSALSOLINE (1974) (0)
STRUCTURE DETERMINATION OF BROMINATED MORPHINAN-6-ONES BY CARBON-13 NMR SPECTROSCOPY: A NOVEL CLOSURE OF THE OXYGEN BRIDGE USING 4-ACETOXYMORPHINAN-6-ONES (1981) (0)
MAMMALIAN ALKALOIDS. 8. SYNTHESIS AND BIOLOGICAL EFFECTS OF TETRAHYDROPAPAVEROLINE RELATED 1-BENZYLTETRAHYDROISOQUINOLINES (1980) (0)
Synthesis of Benzo[5,6]cyclohept[1,2,3ij]isoquinolines as Rigid Congeners of Tetrahydropapaveroline (1982) (0)
[Synthesis of isoquinoline. Synthesis of 7-hydroxy-6-methoxy-2methyl-(4-hydroxy-3,5-dimethoxyphenethyl)-1,2,3,4-tetrahydro-isoquinoline, an intermediate in the synthesis of homapomorphine alkaloids]. (1968) (0)
Structure of 3‐O‐demethylcolchicine acetone solvate, C21H23NO6.C3H6O (1985) (0)
(±)-Homoberbines, a new class of heterocyclic compounds (1968) (0)
PROBING OF RECEPTORS WITH NATURAL AND UNNATURAL ALKALOIDS (1984) (0)
SYNTHESIS OF BENZO(5,6)CYCLOHEPT(1,2,3,IJ)ISOQUINOLINES AS RIGID CONGENERS OF TETRAHYDROPAPAVEROLINE (1982) (0)
Chemistry and Biotechnology of Biologically Active Natural Products. Edited by Cs. Szántay, Á. Gottsegen, and G. Kovács (1985) (0)
Invited Review. Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties (1996) (0)
Correction. Syntheses in the Isoquinoline Series. Synthesis and Chemical Transformation of the 2,3-Dihydro-4(1H)-isoquinolones (1968) (0)
1-Phenethyl-2,3,4,5-tetrahydro-1H-2-benzazepines from 2-Acetyl-1-methylene-2,3,4,5-tetrahydro-1H-2-benzazepines. (1988) (0)
Synthesis of (.+‐.)‐trans‐2,5‐Dialkylpyrrolidines from the Lukes‐Sorm Dilactam: Efficient Preparation of (.+‐.)‐trans‐2‐Butyl‐5‐heptylpyrrolidine and Analogs Present in Ant Venoms. (1988) (0)
Opening of ring B in griseofulvin. (1965) (0)
TOTALSYNTH. DES ALKALOIDS RHOEADIN (1972) (0)
Stereocontrolled Conversion of 3,5-Dioxopyrrolizidine into Z- and E-5-Acetonylpyrrolizidin-3-ones. (1990) (0)
[Preparation and properties of 1,2,3,4,5,6-hexahydro-8-hydroxy-3-methyl-3-benzazocine]. (1971) (0)
Antitumor Agents. Part 184. Syntheses and Antitubulin Activity of Compounds Derived from Reaction of Thiocolchicone with Amines: Lactams, Alcohols, and Ester Analogues of Allothiocolchicinoids. (1998) (0)
Natural Products. Antitubulin Effect of Congeners of N-Acetylcolchinyl Methyl Ether: Synthesis of Optically Active 5- Acetamidodeaminocolchinyl Methyl Ether and of Demethoxy Analogues of Deaminocolchinyl Methyl Ether. (1993) (0)
Di‐(2,2,2‐Trichloroethyl) Carbonate: By‐Product in Reactions with 2,2, 2‐Trichloroethyl Chloroformate. (1991) (0)
Phenserine and Ring C Hetero‐Analogues: Drug Candidates for the Treatment of Alzheimer′s Disease (2010) (0)
Antitumor Agents. Part 192. Antitubulin Effect and Cytotoxicity of C(7)-Oxygenated Allocolchicinoids. (1999) (0)
(-)-4-HYDROXY-N-FORMYLMORPHINAN-6-ONE, A VERSATILE INTERMEDIATE FOR THE SYNTHESIS OF 3-DEOXYOPIOIDS (1981) (0)
AROMATIZATION OF 1-BENZYLTETRAHYDROISOQUINOLINES: RACEMIZATION OF (-)-(S)-(N-NOR)-RETICULINE (1981) (0)
7-OXODEACETAMIDOCOLCHICEINE AND 7-BENZYLIMINODEACETAMIDOCOLCHICEINE- TWO NOVEL PRODUCTS FROM THE BASE CATALYZED REACTION O (-)-N-BENZYLIDENEDEACETYLCOLCHICEINE (1978) (0)
Phenseriner and substituted phenyl carbamates of the (-) - eseroline, (-) - N1-noreseroline and (-) - N1-benzylnoreserolin as specific inhibitors of acetylcholinesterase (1992) (0)
Reduction of Pheny1-Substituted Pyridinium Methoiodides with Sodium Borohydride. (1986) (0)
CONVERSION OF NATURAL (S)-BULBOCAPNINE INTO TWO (RING A)-SUBSTITUTED DERIVATIVES OF (R)-APOMORPHINE (1979) (0)
Facile Preparation of (3S)-1,3-Dimethyl-3-cyanomethyl-5-ethoxyoxindole from Julian′s Nitrile Enriched in the (3S)-Enantiomer. (2010) (0)
APOMORPHINANS FROM ISOQUINOLINES: GREWE CYCLIZATION OF 1-(2-HYDROXYBENZYL)-N-METHYLOCTAHYDROISOQUINOLINE AND ITS O-METHYL ETHER (1984) (0)
Preface of the Special Issue "30 Years Heterocycles" (2003) (0)
Structure-Activity Relationships in the Colchicine Molecule with Respect to Interaction with the Mammalian Multidrug Transporter, P- Glycoprotein (1995) (0)
1‐Oxotetrahydro‐2‐benzazepines from 1‐Methyl‐3,4‐dihydro‐5H‐2‐benzazepines: Synthesis of N‐Methyl‐7,8,9‐trimethoxy‐2,3,4,5‐tetrahydro‐1H‐2benzazepine. (1987) (0)
SELECTIVE O-DEMETHYLATION OF AN AROMATIC METHYL ETHER IN THE PRESENCE OF AN AROMATIC METHYLENEDIOXY GROUP WITH TRIMETHYLSILYL IODIDE IN QUINOLINE (1978) (0)
"Unnatural alkaloids" (1979) (0)
Phenserine and substituted phenylcarbamate of (-) - eseroline, (-) - n1-noreseroline and (-) - n1-benzylnoresorolin as specific acetylcholinesterase inhibitors (1992) (0)
[OXYGEN ANALOGUES OF HARMAN DERIVATIVES: CHEMISTRY AND PHARMACOLOGY]. (1963) (0)
A NOVEL SYNTHESIS OF APORPHINES VIA 3-PHENYLPHENETHYLAMINES (1979) (0)
PARADOXICAL EFFECTS OF N-CYANOALKYL SUBSTITUENTS UPON THE ACTIVITIES OF SEVERAL CLASSES OF OPIOIDS (1979) (0)
NITROHISTIDINES AND NITROHISTAMINES (1973) (0)
Fragmentation of Optically Active (1-Phenylethyl)- and (1-Naphthylethyl)ureas in Refluxing Alcohols: Easy Preparation of Optically Active Amines of High Optical Purity. (1986) (0)
[Alkaloids in human tissue. Base catalysed epimerization of derivatives from condensation products of L- and D-dopa with acetaldehyde]. (1975) (0)
ESTERS OF 1-O-DEMETHYLTHIOCOLCHICINES: FORMATION OF ISOMERS IN CHLOROFORM SOLUTION (1985) (0)
Deaminocolchinyl Methyl Ether: Synthesis from 2,3,4,4′-Tetramethoxybiphenyl-2-carbaldehyde. Comparison of Antitubulin Effects of Deaminocolchinyl Methyl Ether and Dehydro Analogues. (1990) (0)
Alkaloids of Templetonia retusa. Chemistry, Structure and Absolute Configuration of (-)-Templetine. (1991) (0)
Tris-N,N′,N′′-(3′,4′,5′-trimethoxyphenethyl)-1,3,5-hexahydrotriazine, a Methylenemescaline Trimer: Characterization and Selective Cyclization to Anhalinine Under Non-Aqueous Conditions. (1990) (0)
Alkaloids: Chemistry and Pharmacology V29 (1986) (0)
Optically active tetrahydro-.alpha.-phenyl-6,7-dimethoxyisoquinoline-1-methanols from (1-phenylethyl)ureas. Absolute configuration of (-)- and (+)-isomers of the erythro series [Erratum to document cited in CA111(3):23762z] (1989) (0)
STRUCTURE-ACTIVITY RELATIONSHIP OF OXYGENATED MORPHINANS. V. NARCOTIC AGONIST T AND ANTAGONIST ACTIVITY IN THE 14-HYDROXYMORPHINAN SERIES. PRELIMINARY COMMUNICATION (1982) (0)
C-1-2 New Syntheses of 8-Hydroxy-1,2,3,4-tetrahydroisoquinoline Cactus Alkaloids(Alkaloids and alkaloid biosynthesis) (1964) (0)
N‐Demethylation of (.+‐.)‐6β‐Acetoxy‐3‐tropinone. Synthesis of (.+ ‐.)‐6β‐Acetoxynortropane. (2010) (0)
Chiral Prodyes. Ethers and Esters of Dihydrofluorescein. Part 1. Dibenzyldihydrofluorescein (DBDF), a New Reagent. (1991) (0)
Commemoration for 65th Birthday, December 19, 1988 (1988) (0)
Expedient synthesis of (S)- and (R)-norcoclaurine from (S)- and (R)-norarmepavine [corrected] prepared by the 1-phenylethylurea method. (1990) (0)
(.+-.)-2-DEPENTYLPERHYDROHISTRIONICOTOXIN: A NEW PROBE FOR A REGULATORY SITE ON THE NICOTINIC ACETYLCHOLINE RECEPTOR-CHANNEL (1983) (0)
Compounds having selective inhibition of cholinesterase acteil. (1992) (0)
The physostigmine controversy (1989) (0)
STRUCTURE-ACTIVITY RELATIONSHIP OF OXYGENATED MORPHINANS. VII. 5-METHYLATED AND 14-HYDROXY-SUBSTITUTED AGONISTS AND ANTAGONISTS OF THE 4-HYDROXY- AND 3,4-DIOXYGENATED 6-MORPHINANONE SERIES (1983) (0)
Synthesis and Tubulin Interaction of Thiocolchicines Containing an Isothiocyanato Group. Synthesis of C(2)-Deuterated and C(2)-14C- Labeled 7-Isothiocyanatodeacetamidothiocolchicine. (1992) (0)
In Memory of Tetsuji Kametani (1989) (0)
Cholinesterase inhibitors, pharmaceutical compositions and their uses. (1992) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Arnold Brossi?

Arnold Brossi is affiliated with the following schools:

National Taiwan University
University of Florence
University of North Carolina at Chapel Hill
Duke University

Arnold Brossi's Academic­Influence.com Rankings

Arnold Brossi's Degrees

Why Is Arnold Brossi Influential?

Arnold Brossi's Published Works

Published Works

What Schools Are Affiliated With Arnold Brossi?

Arnold Brossi's AcademicInfluence.com Rankings