Arthur M. Brown
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Arthur M. Brownbiology Degrees
Biology
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#19296
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Neuroscience
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Biology
Arthur M. Brown's Degrees
- Bachelors Biology Stanford University
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(Suggest an Edit or Addition)Arthur M. Brown's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning (1989) (446)
- Evidence for a Cardiac Ion Channel Mutation Underlying Drug‐Induced QT Prolongation and Life‐Threatening Arrhythmias (2000) (308)
- Role of the Cytosolic Chaperones Hsp70 and Hsp90 in Maturation of the Cardiac Potassium Channel hERG (2003) (306)
- The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits (1988) (282)
- Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle (1989) (282)
- MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes (2013) (278)
- A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG (1997) (277)
- Mechanisms of arsenic-induced prolongation of cardiac repolarization. (2004) (272)
- Normalization of current kinetics by interaction between the α1and β subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel (1991) (270)
- Gating of inwardly rectifying K+ channels localized to a single negatively charged residue (1994) (260)
- Pentamidine-Induced Long QT Syndrome and Block of hERG Trafficking (2005) (248)
- Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern. (2004) (228)
- Effects of protein kinase C activators on cardiac Ca2+ channels (1988) (225)
- Alteration and restoration of K+ channel function by deletions at the N- and C-termini (1990) (184)
- The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes. (2010) (174)
- The Binding Site for Channel Blockers That Rescue Misprocessed Human Long QT Syndrome Type 2 ether-a-gogo-related Gene (HERG) Mutations* (2002) (165)
- Erratum: Long QT syndrome patients with mutations on the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate: Implications for gene-specific therapy (Circulation (1995) 92 (3381-3386)) (1996) (163)
- Cloning and Expression of a Novel K+ Channel Regulatory Protein, KChAP* (1998) (136)
- Fast and slow gating of sodium channels encoded by a single mRNA (1990) (133)
- HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk. (2005) (132)
- C‐terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1. (1995) (125)
- K+ pore structure revealed by reporter cysteines at inner and outer surfaces (1995) (115)
- Molecular Biology of Membrane Transport Disorders (1996) (104)
- Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current (1996) (102)
- Electrocardiographic Prediction of Abnormal Genotype in Congenital Long QT Syndrome: Experience in 101 Related Family Members (2001) (99)
- Alfuzosin Delays Cardiac Repolarization by a Novel Mechanism (2008) (95)
- Drugs, hERG and sudden death. (2004) (90)
- Separable Kvβ Subunit Domains Alter Expression and Gating of Potassium Channels* (1997) (85)
- Comparison of Binding and Block Produced by Alternatively Spliced Kvβ1 Subunits* (1996) (80)
- An Electrogenic Sodium Pump and Baroreceptor Function in Normotensive and Spontaneously Hypertensive Rats (1976) (73)
- Pathways of HERG inactivation. (1999) (72)
- Potassium Channel Structure and Function as Reported by a Single Glycosylation Sequon (*) (1995) (72)
- A history of the role of the hERG channel in cardiac risk assessment. (2013) (71)
- Increased K+ Efflux and Apoptosis Induced by the Potassium Channel Modulatory Protein KChAP/PIAS3β in Prostate Cancer Cells* (2002) (68)
- Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+ exchanger. (2003) (64)
- Neuromodulation (1992) (57)
- Angiotensin II Modulates Cardiac Na+ Channels in Neonatal Rat (1989) (57)
- Optical mapping reveals conduction slowing and impulse block in iron-overload cardiomyopathy. (2003) (54)
- Correlation between G protein activation and reblocking kinetics of Ca2+ channel currents in rat sensory neurons (1991) (51)
- Deferoxamine promotes survival and prevents electrocardiographic abnormalities in the gerbil model of iron-overload cardiomyopathy. (2003) (46)
- Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs (2001) (46)
- Increased Cardiac Risk in Concomitant Methadone and Diazepam Treatment: Pharmacodynamic Interactions in Cardiac Ion Channels (2010) (39)
- Evaluating State Dependence and Subtype Selectivity of Calcium Channel Modulators in Automated Electrophysiology Assays (2014) (36)
- Vanoxerine: Cellular Mechanism of a New Antiarrhythmic (2010) (36)
- Variable Expression of Long QT Syndrome Among Gene Carriers from Families with Five Different HERG Mutations (2001) (32)
- Mutations in the Kvβ2 Binding Site for NADPH and Their Effects on Kv1.4* (2001) (32)
- Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk (2015) (32)
- Bimodal cardiac dysfunction in an animal model of iron overload. (2002) (31)
- New Positive Inotropic Agent OPC-8212 Modulates Single Ca2+ Channels in Ventricular Myocytes of Guinea Pig (1989) (31)
- Interactions among Inactivating and Noninactivating Kvβ Subunits, and Kvα1.2, Produce Potassium Currents with Intermediate Inactivation* (1997) (30)
- HERG channel trafficking. (2005) (28)
- Novel Sites of N-Glycosylation in ROMK1 Reveal the Putative Pore-forming Segment H5 as Extracellular* (1996) (28)
- Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy. (2003) (27)
- HERG block, QT liability and sudden cardiac death. (2005) (25)
- Test article concentrations in the hERG assay: losses through the perfusion, solubility and stability. (2009) (21)
- COR-ART: A multicenter, randomized, double-blind, placebo-controlled dose-ranging study to evaluate single oral doses of vanoxerine for conversion of recent-onset atrial fibrillation or flutter to normal sinus rhythm. (2015) (19)
- Contribution of the NH2terminus of Kv2.1 to channel activation. (1997) (18)
- An ion channel library for drug discovery and safety screening on automated platforms. (2008) (18)
- Inwardly rectifying single-channel and whole cell K+ currents in rat ventricular myocytes (2005) (16)
- Vanoxerine, a New Drug for Terminating Atrial Fibrillation and Flutter (2010) (14)
- Mapping the Kidney Potassium Channel ROMK1 (1997) (14)
- High throughput functional screening of an ion channel library for drug safety and efficacy (2009) (13)
- Membrane-delimited cell signaling complexes: Direct ion channel regulation by G Proteins (2007) (9)
- Oral Vanoxerine Prevents Reinduction of Atrial Tachyarrhythmias: Preliminary Results (2011) (7)
- hERG Assay, QT Liability, and Sudden Cardiac Death (2005) (6)
- Chapter 1 G proteins and transmembrane signalling (1988) (5)
- Carbon Dioxide Action on Neuronal Membranes (1974) (4)
- Voltage Clamp and Internal Perfusion With Suction-Pipette Method (1985) (3)
- Voltage-Gated Ionic Channels: Diversity and Modulation by Mg2+ (1991) (3)
- Evaluation of Contractile Activity of Stem Cell-Derived Human Cardiomyocytes using Impedance Analysis (2013) (3)
- Yang et al response (2003) (2)
- EVERY STEP OF THE WAY The Comprehensive In Vitro Proarrhythmia Assay ( CiPA ) Guide : A New Approach to Cardiac Risk Assessment (2016) (2)
- Cellular basis of the photoresponse of an extraretinal photoreceptor (1982) (2)
- Ion Channel Genes in the Heart (1996) (2)
- Optimizing Rate Correction of Field Potential Duration, a Biomarker for QT Risk Assessment, in Human Ipsc-Cardiomyocytes (2014) (2)
- Ontogeny of calcium channels in myogenic cell lines: Regulation by growth factors and transfected oncogenes (1987) (1)
- Pharmacology of sodium currents in single heart cells (1984) (1)
- A Small Analog Computer for Continuous Measurement of Intracellular Ion Activities (1971) (1)
- Quantification of cardioactive drug effects using xCELLigence RTCA cardio and human stem cell-derived cardiomyocytes (2013) (1)
- Corrigendum: Cellular dysfunction of LQT5-minK mutants: Abnormalities of IKs, IKr and trafficking in long QT syndrome (Human Molecular Genetics (1999) 8 (1499-1507)) (1999) (1)
- KChAP as a chaperone for specific K 1 channels (1)
- Arrhythmias depending upon a cardio cardiac sympathetic reflex (1975) (1)
- Cell engineering and expression of ion channels (1995) (0)
- Contents volume 43 (1992) (0)
- High throughput screening of a panel of ion channel expressing cell lines (2008) (0)
- Variability of the Field Potential Duration of Stem Cell-Derived Cardiomyocytes is a Proarrhythmic Indicator (2016) (0)
- Neuromodulation (1992) (0)
- NONCLINICAL TESTS ON ALFUZOSIN PREDICT DELAYED CARDIAC REPOLARIZATION (2007) (0)
- G protein gating of Ca2+ and K+ channels (1990) (0)
- Stem cell-derived human cardiomyocyte action potential assay for cardiac risk evaluation (2010) (0)
- Modulators and blockers of ion channel pores (1992) (0)
- Brittenham et al response (2004) (0)
- Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg (1990) (0)
- Vardenafil increases the beat rate of human cardiomyocytes via potentiation of HCN4 channel currents (2011) (0)
- Pharmacological Characterization of NR1/NR2A and NR1/NR2B Glutamate Receptors using an Electrophysiology Based HTS Assay (2015) (0)
- activation terminus of Kv 2 . 1 to channel 2 Contribution of the NH (1997) (0)
- Detection of complex mechanisms of drug action for vardenafil using stem cell-derived human cardiomyocytes (2013) (0)
- Action potentials from stem cell-derived cardiomyocyte clusters for cardiac safety screening (2015) (0)
- Na and Ca Channels in the Heart (1987) (0)
- Pharmacological Identification of an L-Type Calcium Channel Impedance Signal in Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes (2017) (0)
- Regulation of Voltage-Activated K+ Channels (1992) (0)
- Blockade of HERG and Kv 1 . 5 by Ketoconazole 1 (1998) (0)
- Optimizing rate correction of field potential duration, a biomarker for QT risk assessment (2014) (0)
- Models based on multiple ion channel effects more predictive of cardiac risk (2013) (0)
- Differential response to mexiletine, catecholamines and pacing, in a cellular model mimicking the SCN5A and HERG genes defect present in the long QT syndrome (1996) (0)
- Characterization of the L-type calcium current in human stem cell-derived cardiomyocytes (2011) (0)
- Cloned human heart delayed rectifier K+ channels (1996) (0)
- Biphasic inhibition of voltage-dependent cardiac sodium currents by isoproterenol (1990) (0)
- Model of Signal Transduction by G Proteins (1990) (0)
- GBR-12909: Potent Blocker of Peak and Late Nav1.5 Currents (2015) (0)
- Cardiac channel panel™: A critical path tool for understanding cardiac risk (2009) (0)
- Sodium and calcium single channel currents in neonatal cardiac myocytes (1986) (0)
- Vanoxerine: A case study supporting quantitative profiling for assessing cardiac risk (2016) (0)
- Truncating K+ channels and ras/GAP channel modulators*1 (1991) (0)
- Comparison of In-Cell Immunoassay and Automated Electrophysiology for Assessment of hERG Trafficking Liability for New Drugs (2017) (0)
- Assessment of KvLQT1/minK liability in safety pharmacology (2014) (0)
- A Small Analog Computer forContinuousMeasure- ment of Intracellular JonActivities (1971) (0)
- hERG vs. APD/QT results often discordant: Fast and accurate repolarization screen a necessity early in development (2009) (0)
- CiPA validation of moxifloxacin as a positive control to assess cardiac risk (2016) (0)
- Methadone-induced action potential prolongation in human cardiomyocytes is enhanced by diazepam (2011) (0)
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