Arthur Pardee
American biochemist
Arthur Pardee's AcademicInfluence.com Rankings
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Biology
Arthur Pardee's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Arthur Pardee Influential?
(Suggest an Edit or Addition)According to Wikipedia, Arthur Beck Pardee was an American biochemist. One biographical portrait begins "Among the titans of science, Arthur Pardee is especially intriguing." There is hardly a field of molecular biology that is not affected by his work, which has advanced our understanding through theoretical predictions followed by insightful experiments. He is perhaps most famous for his part in the 'PaJaMo experiment' of the late 1950s, which greatly helped in the discovery of messenger RNA. He is also well known as the discoverer of the restriction point, in which a cell commits itself to certain cell cycle events during the G1 cycle. He did a great deal of work on tumor growth and regulation, with a particular focus on the role of estrogen in hormone-responsive tumors. He is also well known for the development of various biochemical research techniques, most notably the differential display methodology, which is used in examining the activation of genes in cells. More recently he championed the acceptance and adoption of the conceptual review as a valuable approach to unearthing new knowledge from the enormous stores of information in the scientific literature. He died in February 2019 at the age of 97.
Arthur Pardee's Published Works
Published Works
- Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. (1992) (5217)
- G1 events and regulation of cell proliferation. (1989) (2286)
- A restriction point for control of normal animal cell proliferation. (1974) (1384)
- The genetic control and cytoplasmic expression of “Inducibility” in the synthesis of β-galactosidase by E. coli (1959) (964)
- Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. (1993) (885)
- The enzymology of control by feedback inhibition. (1962) (767)
- Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation (1984) (658)
- Animal cell cycle. (1978) (653)
- Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. (1995) (621)
- Redundant cyclin overexpression and gene amplification in breast cancer cells. (1993) (548)
- Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. (1991) (480)
- The Restriction Point of the Cell Cycle (2002) (424)
- NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis (2004) (398)
- Cyclin E, a potential prognostic marker for breast cancer. (1994) (391)
- Differential display using one-base anchored oligo-dT primers. (1994) (371)
- Suppression of cancer relapse and metastasis by inhibiting cancer stemness (2015) (365)
- Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. (1992) (363)
- Control of pyrimidine biosynthesis in Escherichia coli by a feed-back mechanism. (1956) (352)
- Centriole ciliation is related to quiescence and DNA synthesis in 3T3 cells (1979) (351)
- Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. (2000) (331)
- Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. (1986) (327)
- Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells (2000) (319)
- Mechanism by which caffeine potentiates lethality of nitrogen mustard. (1982) (315)
- Transport of amino acids by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips. (1969) (297)
- Recent advances in differential display. (1995) (283)
- Multienzyme complex for metabolic channeling in mammalian DNA replication. (1980) (276)
- Synthesis of labile, serum-dependent protein in early G1 controls animal cell growth. (1979) (259)
- NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. (2004) (244)
- Transport changes rapidly initiated by serum addition to "contact inhibited" 3T3 cells. (1969) (232)
- Metastasis and AKT activation (2008) (230)
- Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. (1993) (228)
- The initial kinetics of enzyme induction. (1961) (225)
- DNA synthesis inhibition and the induction of protein X in Escherichia coli. (1976) (221)
- Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli. (1962) (206)
- beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. (1993) (203)
- Model for regulation of Escherichia coli DNA repair functions. (1975) (203)
- Growth of Cells in Hormonally Defined Media (1982) (202)
- Cancer Therapy with -Lapachone (2002) (199)
- An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology. (1990) (199)
- THE DEPENDENCE OF NUCLEIC ACID SYNTHESES ON THE PRESENCE OF AMINO ACIDS IN ESCHERICHIA COLI (1956) (194)
- Tat Protein Induces Human Immunodeficiency Virus Type 1 (HIV-1) Coreceptors and Promotes Infection with both Macrophage-Tropic and T-Lymphotropic HIV-1 Strains (1998) (191)
- Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I. (1989) (188)
- Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. (1998) (186)
- Exploiting cancer cell cycling for selective protection of normal cells. (2001) (172)
- Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment (2000) (168)
- Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints. (1999) (167)
- Cytidine triphosphate synthetase of Escherichia coli B. I. Purification and kinetics. (1967) (165)
- Control of thymidine kinase mRNA during the cell cycle (1987) (163)
- Evidence for defective retinoid transport and function in late onset Alzheimer's disease (2003) (163)
- A binding site for sulfate and its relation to sulfate transport into Salmonella typhimurium. (1966) (161)
- The nuclear factor kappa B (NF-κB): A potential therapeutic target for estrogen receptor negative breast cancers (2001) (158)
- Identification of rCop-1, a New Member of the CCN Protein Family, as a Negative Regulator for Cell Transformation (1998) (154)
- Multiple pathways of putrescine biosynthesis in Escherichia coli. (1966) (154)
- Changes of membrane proteins and their relation to deoxyribonucleic acid synthesis and cell division of Escherichia coli. (1970) (153)
- Role Reversal for Anticancer Agents (2002) (151)
- Selective killing of cancer cells by β-lapachone: Direct checkpoint activation as a strategy against cancer (2003) (150)
- Metastasis and AKT activation (2009) (144)
- Purification and properties of a sulfate-binding protein from Salmonella typhimurium. (1966) (143)
- Measurement of oxygen uptake under controlled pressures of carbon dioxide. (1949) (142)
- Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei (1983) (139)
- Linking gene expression patterns to therapeutic groups in breast cancer. (2000) (139)
- High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood (2001) (137)
- Control by uracil of formation of enzymes required for orotate synthesis. (1957) (136)
- Analysis of altered gene expression by differential display. (1995) (136)
- New primer strategy improves precision of differential display. (1995) (135)
- Induction of Apoptosis by β-Lapachone in Human Prostate Cancer Cells (1995) (134)
- Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells. (1982) (134)
- Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. (2000) (132)
- Studies in Mutagenesis: Production of Bacteriophage Mutants by a Disturbance of Deoxyribonucleic Acid Metabolism (1956) (131)
- Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin. (1998) (128)
- Analysing differential gene expression in cancer (2003) (127)
- Cyclin E and cyclin A as candidates for the restriction point protein. (1993) (127)
- Association of K-ras mutations with p16 methylation in human colon cancer. (1999) (126)
- Tat protein induces self-perpetuating permissivity for productive HIV-1 infection. (1997) (125)
- Two differentially expressed genes in normal human prostate tissue and in carcinoma. (1996) (121)
- Pyrimidine biosynthesis in Escherichia coli. (1956) (120)
- Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. (2010) (119)
- Differential display. A general protocol. (1998) (119)
- Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. (1986) (118)
- Cell Cycle-regulated Phosphorylation of the Human SIX1 Homeodomain Protein* (2000) (118)
- Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1. (1995) (116)
- Sialic acid contents and controls of normal and malignant cells. (1968) (113)
- The Effect of the Feedback Inhibitor, CTP, on Subunit Interactions in Aspartate Transcarbamylase (1963) (112)
- Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type 1 in human peripheral blood mononuclear cells and in cultured T cells. (1991) (110)
- Synthesis of macromolecules in synchronously dividing bacteria (1960) (109)
- The abbreviated pluripotent cell cycle (2013) (109)
- Transport changes in synchronously growing CHO and L cells (1972) (108)
- The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts. (1985) (106)
- Loss of epidermal growth factor requirement and malignant transformation. (1979) (106)
- Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor (1984) (105)
- Fatty acid-requiring mutant of bacillus subtilis defective in branched chain alpha-keto acid dehydrogenase. (1971) (105)
- Selective killing of transformed baby hamster kidney (BHK) cells. (1975) (104)
- G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. (1994) (99)
- Differential display (1998) (99)
- Thymidine and Thymine Incorporation into Deoxyribonucleic Acid: Inhibition and Repression by Uridine of Thymidine Phosphorylase of Escherichia coli (1967) (98)
- Exponential 3T3 cells escape in mid-G1 from their high serum requirement. (1978) (98)
- Enhanced synthesis and stabilization of Mr 68,000 protein in transformed BALB/c-3T3 cells: candidate for restriction point control of cell growth. (1983) (97)
- Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge. (1999) (97)
- A second permease for methyl-thio-β-d-galactoside in Escherichia coli (1965) (96)
- The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle (1994) (96)
- Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase. (1992) (95)
- Crossroads of Estrogen Receptor and NF-κB Signaling (2005) (93)
- Pentoxifylline decreases tumor necrosis factor expression and serum triglycerides in people with AIDS. NIAID AIDS Clinical Trials Group. (1993) (92)
- Cell Proliferation and Differentiation (2003) (92)
- Down-Regulation of Laminin-5 in Breast Carcinoma Cells (1998) (90)
- The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme. (1993) (90)
- Conceptual biology: Unearthing the gems (2002) (90)
- Inhibition of succinic dehydrogenase by oxalacetate. (1948) (89)
- Cancer and the cell cycle (1999) (88)
- Enzyme synthesis in synchronous cultures of bacteria. (1964) (88)
- Regulation of S100P expression by androgen (1996) (87)
- Inhibition of radiation-induced neoplastic transformation by beta-lapachone. (1989) (86)
- Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran- 5,6-dione), a novel DNA repair inhibitor. (1987) (85)
- Changes in the synthesis of actin and other cell proteins after stimulation of serum-arrested cells. (1979) (83)
- Apoptosis Caused by Chemotherapeutic Inhibition of Nuclear Factor-κB Activation (2003) (83)
- On the expression of a structural gene (1960) (83)
- Genetics of Sulfate Transport by Salmonella typhimurium (1971) (83)
- Intracellular pH is increased after transformation of Chinese hamster embryo fibroblasts. (1987) (82)
- Cancer therapy with beta-lapachone. (2002) (81)
- Coupled ribonucleoside diphosphate reduction, channeling, and incorporation into DNA of mammalian cells. (1982) (80)
- Molecules involved in proliferation of normal and cancer cells: presidential address. (1987) (80)
- Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation. (2007) (80)
- Prevalent deficiency in tumor cells of cycloheximide-induced cycle arrest. (1980) (78)
- Energy requirement for degradation of tumor-associated protein p53 (1984) (77)
- Regulation of flavin synthesis by Escherichia coli. (1962) (77)
- Nuclear posttranscriptional processing of thymidine kinase mRNA at the onset of DNA synthesis. (1988) (77)
- Bursts of enzyme synthesis in the bacterial duplication cycle (1965) (76)
- Expression of cyclins E1 and E2 during mouse development and in neoplasia (2001) (75)
- The cell surface and fibroblast proliferation some current research trends. (1975) (75)
- Conditional Mutator Gene in Escherichia coli : Isolation , Mapping , and Effector Studies (74)
- Ras activation of genes: Mob-1 as a model. (1994) (74)
- Effects of ciprofloxacin on eucaryotic pyrimidine nucleotide biosynthesis and cell growth (1987) (73)
- A biosynthetic ornithine decarboxylase in Escherichia coli. (1965) (73)
- Production and Crystallization of Aspartate Transcarbamylase (1960) (73)
- AN INDUCIBLE MECHANISM FOR ACCUMULATION OF MELIBIOSE IN ESCHERICHIA COLI (1957) (71)
- Proteins made in the mammalian cell cycle. (1971) (71)
- In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa. (1988) (71)
- Kinetics of G1 transit following brief starvation for serum factors. (1984) (70)
- S phase synchrony in monolayer CHO cultures. (1976) (70)
- The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers. (2001) (69)
- Location of Sulfate-binding Protein in Salmonella typhimurium (1968) (69)
- Inhibition of an early event in the cell division cycle of Escherichia coli by FL1060, an amidinopenicillanic acid (1975) (69)
- Fluorescence of some proteins, nucleic acids and related compounds. (1956) (69)
- p21WAF1/CIP1/SDI1 is elevated through a p53-independent pathway by mimosine. (1996) (69)
- Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists (1997) (69)
- Identification of a gene encoding a human oxysterol-binding protein-homologue: a potential general molecular marker for blood dissemination of solid tumors. (1999) (68)
- Regulation of threonine biosynthesis in Escherichia coli. (1958) (68)
- Inhibitor evidence for allosteric interaction in the replitase multienzyme complex (1983) (68)
- Role of nuclear size in cell growth initiation. (1979) (67)
- Inducible proteins binding to the murine thymidine kinase promoter in late G1/S phase. (1991) (67)
- Incorporation of azatryptophan into proteins of bacteria and bacteriophage. (1956) (66)
- Arrested states produced by isoleucine deprivation and their relationship to the low serum produced arrested state in Swiss 3T3 cells. (1978) (65)
- A study of the ribonucleic acid of normal and chloromycetin-inhibited bacteria by zone electrophoresis. (1957) (65)
- Effects of azatryptophan on bacterial enzymes and bacteriophage. (1958) (65)
- Accumulation of a Protein Required for Division During the Cell Cycle of Escherichia coli (1970) (64)
- Different responses to drugs and serum of cells transformed by various means. (1979) (63)
- Sequence of enzyme synthesis and gene replication during the cell cycle of Bacillus subtilis. (1965) (63)
- Effects of radiophosphorus decay on some synthetic capacities of bacteria. (1958) (58)
- Crystallization of a Sulfate-Binding Protein (Permease) from Salmonella typhimurium (1967) (56)
- Cell cycle studies of mononucleate and cytochalasin-B--nduced binucleate fibroblasts. (1975) (56)
- Pentoxifylline inhibits HIV-1 LTR-driven gene expression by blocking NF-kappa B action. (1993) (56)
- A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter (1995) (56)
- Cytokine dysregulation in AIDS: in vivo overexpression of mRNA of tumor necrosis factor-alpha and its correlation with that of the inflammatory cytokine GRO. (1992) (56)
- Principles of differential display. (1999) (55)
- Inducible transport of citrate in a Gram-positive bacterium, Bacillus subtilis. (1971) (54)
- NUCLEIC ACID PRECURSORS AND PROTEIN SYNTHESIS. (1954) (54)
- Differential display methods and protocols (1997) (54)
- Malonate inhibition of oxidations in the Krebs tricarboxylic acid cycle. (1949) (54)
- ASPARTATE TRANSCARBAMYLASE, AN ENZYME DESIGNED FOR FEEDBACK INHIBITION. (1964) (53)
- On the nature of the repressor of β-galactosidase synthesis in Enscherichia coli (1959) (51)
- Both protein kinase C and calcium mediate activation of the Na+/H+ antiporter in Chinese hamster embryo fibroblasts (1987) (51)
- Cell-cycle-specific interaction of nuclear DNA-binding proteins with a CCAAT sequence from the human thymidine kinase gene. (1987) (51)
- Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation. (2003) (51)
- The induction of mutants of bacteriophage T2 by 5-bromouracil. III. Nutritional and structural evidence regarding mutagenic action. (1960) (50)
- Association of the mammalian helicase MAH with the pre-mRNA splicing complex. (1997) (50)
- Calmodulin Is Essential for Estrogen Receptor Interaction with Its Motif and Activation of Responsive Promoter* (1998) (50)
- Regulation of Sulfate Transport in Salmonella typhimurium (1966) (50)
- Selective isolation of newly synthesized mammalian mRNA after in vivo labeling with 4-thiouridine or 6-thioguanosine. (1988) (49)
- Evidence for a Relationship Between Deoxyribonucleic Acid Metabolism and Septum Formation in Escherichia coli (1968) (49)
- Cooperative inhibition of NF-kappa B and Tat-induced superactivation of human immunodeficiency virus type 1 long terminal repeat. (1993) (48)
- Beta-lapachone greatly enhances MMS lethality to human fibroblasts. (1984) (48)
- Protein turnover and cell-cycle initiation in yeast. (1979) (47)
- Identifying expressed genes. (2000) (47)
- Nuclear factor-κB activation: a molecular therapeutic target for estrogen receptor–negative and epidermal growth factor receptor family receptor–positive human breast cancer (2007) (47)
- C‐myc expression is dissociated from DNA synthesis and cell division in Xenopus oocyte and early embryonic development. (1986) (47)
- Conditional Mutations Involving Septum Formation in Escherichia coli (1967) (46)
- Efficacy of pentoxifylline as a modulator of alkylating agent activity in vitro and in vivo. (1991) (46)
- Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli. (1971) (46)
- Energy transfer in conjugated proteins and nucleic acids. (1956) (46)
- Pentoxifylline and Other Protein Kinase C Inhibitors Down-Regulate HIV-LTR NF-κB Induced Gene Expression (1994) (45)
- Regulation of thymidine kinase activity in the cell cycle by a labile protein (1985) (45)
- Cell division in Escherichia coli: evidence for regulation of septation by effector molecules. (1972) (44)
- Nuclear factor-kappaB activation: a molecular therapeutic target for estrogen receptor-negative and epidermal growth factor receptor family receptor-positive human breast cancer. (2007) (43)
- Calculations on paper chromatography of peptides. (1951) (43)
- Insulin‐like growth factor I regulation of transcription and replicating enzyme induction necessary for DNA synthesis (1986) (43)
- Induction of apoptosis by beta-lapachone in human prostate cancer cells. (1995) (43)
- A need for basic research on fluid-based early detection biomarkers. (2010) (43)
- Anticarcinogenic potential of DNA-repair modulators. (1988) (42)
- Regulation of Pyridine Nucleotide Biosynthesis in Escherichia coli (1962) (42)
- Human immunodeficiency virus type 1 TAT protein activates B lymphocytes. (1997) (42)
- Deoxyribonucleic Acid Synthesis During the Division Cycle of Escherichia coli: a Comparison of Strains B/r, K-12, 15, and 15T− Under Conditions of Slow Growth (1974) (42)
- Inhibition of Escherichia coli Division by Protein X (1978) (41)
- Quiescent cells but not cycling cells exhibit enhanced actin synthesis before they synthesize DNA (1980) (41)
- Identification of differentially expressed genes from limited amounts of RNA. (2000) (40)
- Transplantation of human or rodent tumors into cyclosporine-treated mice: a feasible model for studies of tumor biology and chemotherapy. (1984) (40)
- Selective protection of normal proliferating cells against the toxic effects of chemotherapeutic agents. (2003) (40)
- Experiments in biochemical research techniques (1957) (40)
- Identification and verification of differential display cDNAs using gene-specific primers and hybridization arrays. (1998) (37)
- 2‐Amino‐isobutyric acid and 3‐0‐methyl‐D‐glucose transport in 3T3, SV40‐transformed 3T3 and revertant cell lines (1978) (37)
- Blocking anti-apoptosis as a strategy for cancer chemotherapy: NF-kappaB as a target. (2004) (37)
- Cyclin E — a better prognostic marker for breast cancer than cyclin D? (1996) (37)
- Pentoxifylline and wellbeing in patients with cancer (1990) (36)
- THE CYCLE OF BACTERIAL DUPLICATION. (1963) (36)
- Regulation in S Phase by E2F (2004) (36)
- Improved expression vectors for eukaryotic promoter/enhancer studies. (1991) (36)
- Synergistic effects of epidermal growth factor and thrombin on the growth stimulation of diploid chinese hamster fibroblasts (1980) (36)
- Periodic mitotic events induced in the absence of DNA replication. (1987) (36)
- The induction of mutants of bacteriophage T2 by 5-bromouracil. IV. Kinetics of bromouracil-induced mutagenesis. (1960) (35)
- Histone H1 kinase in exponential and synchronous populations of Chinese hamster fibroblasts. (1986) (35)
- Mob-1, a Ras target gene, is overexpressed in colorectal cancer (1997) (34)
- Cell cycle and growth control : biomolecular regulation and cancer (2005) (34)
- 3‐Aminobenzamide is lethal to MMS‐damaged human fibroblasts primarily during s phase (1984) (34)
- Sulfate-Binding Protein from Salmonella typhimurium: Physical Properties (1970) (34)
- The role of increased proteolysis in the atrophy and arrest of proliferation in serum‐deprived fibroblasts (1984) (33)
- The S phase: Beginning, middle, and end: A perspective (1998) (32)
- The role of sialic acid in the release of proteins from L1210 leukemia cells. (1966) (32)
- CELL DIVISION AND A HYPOTHESIS OF CANCER. (1964) (32)
- Ordered splicing of thymidine kinase pre-mRNA during the S phase of the cell cycle (1990) (31)
- Camptothecin inhibits Tat-mediated transactivation of type 1 human immunodeficiency virus. (1994) (30)
- Cell-free activity of a sulfate binding site involved in active transport. (1966) (30)
- Beginnings of feedback inhibition, allostery, and multi-protein complexes. (2003) (30)
- Identification of prostate cancer mRNA markers by averaged differential expression and their detection in biopsies, blood, and urine (2007) (30)
- EFFECT OF ENERGY SUPPLY ON ENZYME INDUCTION BY PYRIMIDINE REQUIRING MUTANTS OF ESCHERICHIA COLI (1955) (29)
- Three methods for identification of true positive cloned cDNA fragment in differential display. (1996) (29)
- Cell cycle-dependent expression of TAP1, TAP2, and HLA-B27 messenger RNAs in a human breast cancer cell line. (1996) (28)
- Growth-responsive expression from the murine thymidine kinase promoter: genetic analysis of DNA sequences. (1991) (28)
- CONTROL OF ENZYME ACTIVITY IN HIGHER ANIMALS. (1963) (28)
- Transformed and nontransformed cells differ in stability and cell cycle regulation of a binding activity to the murine thymidine kinase promoter. (1990) (28)
- Abolition by cycloheximide of caffeine-enhanced lethality of alkylating agents in hamster cells. (1982) (28)
- Better gel resolution and longer cDNAs increase the precision of differential display. (1996) (27)
- Coordinate inhibition of DNA synthesis and thymidylate synthase activity following DNA damage and repair. (1983) (27)
- Cancer chemotherapy by deoxynucleotide depletion and E2F-1 elevation. (2005) (27)
- Evidence for a sulfate-binding site external to the cell membrane of Salmonella typhimurium. (1965) (27)
- Loss in transformed cells of cell cycle regulation of expression of a nuclear protein recognized by SLE patient antisera. (1989) (27)
- Molecular cloning of transcripts that accumulate during the late G1 phase in cultured mouse cells. (1991) (26)
- Phase I trial of escalating pentoxifylline dose with constant dose thiotepa. (1990) (26)
- Regulation of cell‐cycle initiation in yeast by nutrients and protein synthesis (1978) (26)
- Defective Ca2+ metabolism in Duchenne muscular dystrophy: effects on cellular and viral growth. (1984) (25)
- Unique cytoplasmic phosphoproteins are associated with cell growth arrest (1977) (25)
- A protocol for differential display of mRNA expression using either fluorescent or radioactive labeling (2007) (25)
- On the action of fluorouracil on leukemia cells. (1966) (25)
- Studies on the role of deoxyribonuclease in T2 bacteriophage development. (1956) (24)
- The assay of animal tissues for respiratory enzymes; conditions for oxalacetate oxidation in whole homogenates. (1948) (24)
- Comparative analysis of caffeine and 3-aminobenzamide as DNA repair inhibitors in Syrian baby hamster kidney cells. (1984) (24)
- Down-regulation of tumor necrosis factor expression by pentoxifylline in cancer patients: A pilot study (2005) (24)
- Failure of ultraviolet-irradiated Escherichia coli to produce a cross-reacting protein. (1962) (24)
- The oxidation of acetate-1-C14 by rat tissue in vitro. (1950) (23)
- Mutations of bacteriophage T2 induced by bromouracil in the presence of chloramphenicol. (1959) (23)
- The yang and yin of cell proliferation: An overview (1987) (22)
- Modification of cell proliferation with inhibitors (1992) (22)
- Characterization of the murine thymidine kinase-encoding gene and analysis of transcription start point heterogeneity. (1992) (22)
- Transport of dicarboxylic acids in Bacillus subtilis. Inducible uptake of L-malate. (1972) (22)
- Re-expression of elafin in 21MT2 breast carcinomas by phorbol 12-myristate 13-acetate is mediated by the Ap1 site in the elafin promoter. (1997) (22)
- Ultraviolet-sensitive Targets in the Enzyme-synthesizing Apparatus of Escherichia coli (1967) (22)
- Membrane transport proteins. Proteins that appear to be parts of membrane transport systems are being isolated and characterized. (1968) (22)
- Production of surplus DNA in E. coli, and its effects on bacterial syntheses. (1958) (21)
- Inactivation of β-galactosidase induction by ultraviolet light (1963) (21)
- The increase in desoxyribonuclease of virus-infected E. coli. (1952) (21)
- Photodynamic inactivation of free and vegatative bacteriophage T4. (1967) (20)
- Evolution of transcriptional control from prokaryotic beginnings to eukaryotic complexities. (1999) (20)
- Differential display of mRNA by PCR. (2001) (20)
- Factors modifying 3‐aminobenzamide cytotoxicity in normal and repair‐deficient human fibroblasts (1984) (20)
- Serum-stimulated 3T3 cells undertake a histidinol-sensitive process which G1 cells do not. (1978) (20)
- Gene expression: its specificity and regulation. (1962) (19)
- Degradation of Escherichia coli DNA: Evidence for limitation in vivo by protein X, the recA gene product (1979) (19)
- Growth of cells in hormonally defined media : abstracts of papers presented at the Ninth Cold Spring Harbor Conference on Cell Proliferation, September 1-September 6, 1981 (1981) (19)
- The purification and properties of antibody against p-azophenylarsonic acid and molecular weight studies from light scattering data. (1948) (19)
- [124b] Aspartate transcarbamylase from Escherichia coli: Aspartate + carbamyl phosphate → Carbamyl aspartate + Pi + H+ (1962) (19)
- Inactivation of enzyme formation by ultraviolet light. I. Action spectra and size of the sensitive unit. (1960) (19)
- Cytidine Triphosphate Synthetase of Escherichia coZi (2003) (19)
- Transcriptional activation of thymidine kinase, a marker for cell cycle control. (1996) (18)
- Cell Division of Escherichia coli: Control by Membrane Organization (1973) (18)
- Targeting the NF‐κB pathway in estrogen receptor negative MDA‐MB‐231 breast cancer cells using small inhibitory RNAs (2006) (18)
- Factors affecting the maintenance of oxidative phosphorylation in a kidney homogenate system. (1949) (18)
- Growth control of normal and transformed cells. (1979) (18)
- [The role of the inducible alleles and the constrtutive alleles in the synthesis of beta-galactosidase in zygotes of Escherichia coli]. (1958) (17)
- Topotecan inhibits human immunodeficiency virus type 1 infection through a topoisomerase-independent mechanism in a cell line with altered topoisomerase I (1997) (17)
- THE CHROMOSOMAL LOCATION OF THE STRUCTURAL GENE FOR OROTIDYLIC ACID PYROPHOSPHORYLASE IN ESCHERICHIA COLI. (1964) (17)
- Inosine-containing primers for mRNA differential display. (1995) (17)
- Meeting report; “Molecular neurobiological mechanisms in schizophrenia: seeking a synthesis,” April 11–14, 1999 (2000) (17)
- DNA sequences required for serum-responsive regulation of expression from the mouse thymidine kinase promoter. (1993) (17)
- Loss of viability and β-galactosidase-froming ability as a consequence of tritium decay in Escherichia coli (1963) (16)
- Enzyme activity and bacteriophage infection. II. Activities before and after virus infection. (1952) (16)
- Cyclin D1/cdk2 kinase is present in a G1 phase-specific protein complex Yi1 that binds to the mouse thymidine kinase gene promoter. (1994) (16)
- Synthesis of Escherichia coli cell walls in the presence of penicillin. (1958) (16)
- Green Fluorescent Protein as a Quantitative Reporter of Relative Promoter Activity in E . coli (2000) (15)
- Requirement of Polyamines for Bacterial Division (1970) (15)
- 3'-end cDNA pool suitable for differential display from a small number of cells. (1998) (15)
- Posttranscriptional control of thymidine kinase messenger RNA accumulation in cells released from G0-G1 phase blocks. (1993) (15)
- Regulatory Molecular Biology (2006) (15)
- Expression genetics : differential display (1999) (15)
- DIFFERENCES IN GROWTH REGULATION OF NORMAL AND TUMOR CELLS * (1982) (14)
- Quantification of DNA-protein interaction by UV crosslinking. (1995) (14)
- Biochemical Studies on Active Transport (1968) (14)
- Evidence for inducible, L-malate binding proteins in the membrane of Bacillus subtilis. Identification of presumptive components of the C4-dicarboxylate transport systems. (1974) (13)
- The Biology and Treatment of Cancer (2009) (13)
- A requirement for pyrimidines in the first few minutes of T2 bacteriophage development. (1960) (13)
- Quantitative Method Using Paper Chromatography for Estimation of Reducing Oligosaccharides (1954) (13)
- Quantitative Determination of Amino Acids by Fluorescence of Derivatives on Paper (1956) (12)
- The establishment of β-galactosidase repression in the mating system of Escherichia coli K12☆ (1966) (12)
- Molecular characterization of the murine thymidylate kinase gene. (1995) (12)
- Suppressor Gene in Human Colon Cancer as a Differentiation-related , Putative Metastatic Drg-1 Updated (2000) (12)
- Genetic determination of constitutive enzyme levels. (1962) (12)
- Identification of a novel stress-inducible glycoprotein in Saccharomyces cerevisiae. I. Preliminary characterization. (1988) (12)
- Experiments on the transfer of information from DNA to enzymes. (1959) (12)
- Enhanced lethality by methylxanthines in human bladder cancer cells treated with thiotepa. (1984) (11)
- Regulation, Restriction, and Reminiscences (2002) (11)
- NUTRITIONAL EFFECTS ON FREQUENCIES OF BACTERIAL RECOMBINATION (1962) (11)
- Control of cell division: models from microorganisms. (1968) (11)
- Coordinate Control of S Phase Onset and Thymidine Kinase Expression (1989) (11)
- Biochemical and molecular events regulating cell proliferation (1986) (11)
- Regulation of the Cell Cycle (2005) (11)
- Modulation of expression of the stress-inducible p118 of Saccharomyces cerevisiae by cAMP. II. A study of p118 expression in mutants of the cAMP cascade. (1988) (11)
- beta-Galactosidase formation following decay of 32P in Escherichia coli zygotes. (1962) (11)
- Regulation of transport systems: a means of controlling metabolic rates. (1973) (10)
- THE INTRACELLULAR DISTRIBUTION OF LANSING POLIOMYELITIS VIRUS IN THE CENTRAL NERVOUS SYSTEM OF INFECTED COTTON RATS (1952) (10)
- CHAPTER 2 – Comparative Aspects of Metabolic Control* (1964) (10)
- The Reactions of Antisera Homologous to Various Azophenylarsonic Acid Groups and the p-Azophenylmethylarsinic Acid Group with Some Heterologous Haptens* (1945) (10)
- Ribonucleotides are channeled into a mixed DNA-RNA polymer by permeabilized hamster cells. (1986) (10)
- A Strategy to Identify Genes Associated with Circulating Solid Tumor Cell Survival in Peripheral Blood (1999) (10)
- Inhibitors of HIV-1 transcription. (1994) (9)
- Primary Cilia and Their Role in the Regulation of DNA Replication and Mitosis (1982) (9)
- Identification of mRNAs Differentially Expressed in Quiescence or in Late G1 Phase of the Cell Cycle in Human Breast Cancer Cells by Using the Differential Display Method (1996) (9)
- Cell cycle and growth factor‐dependent phosphoprotein of 78kD differently regulated in normal and transformed mouse fibroblasts (1987) (9)
- DNA replication during episome transfer as studied by bromodeoxyuridine photosensitization. (1969) (9)
- The reaction of simple antigens with purified antibody. (1949) (9)
- The pursuit of oncotargets through understanding defective cell regulation (2010) (8)
- Roots: Molecular basis of biological regulation: Origins from feedback inhibition and allostery (1985) (8)
- The role of X-ray-induced DNA repair processes in mutagenesis and carcinogenesis. (1990) (8)
- Book Review:Genetic Expression in the Cell Cycle. George M. Padilla, Kenneth S. McCarty (1983) (8)
- On deciding which factors regulate cell growth. (1981) (8)
- ON THE INTERNAL PH VALUE OF BACTERIA. (1963) (8)
- Epidermal growth factor-induced nuclear factor kB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells (2000) (7)
- PaJaMas in Paris. (2002) (7)
- Free Energy and Entropy in Metabolism (1967) (7)
- Progression through the cell cycle: an overview. (1990) (7)
- Molecular Mechanisms of the Control of Cell Growth in Cancer (1982) (7)
- Apoptosis and Proliferation (2003) (7)
- A SECOND PERMEASE FOR METHYL-THIO-BETA-D-GALACTOSIDE IN ESCHERICHIA COLI. (1965) (7)
- Inhibition of HIV-1 replication by combination of a novel inhibitor of TNF-alpha with AZT. (1998) (7)
- Perspectives on cellular regulation : from bacteria to cancer : essays in honor of Arthur B. Pardee (1991) (6)
- On the nature of the repressor of beta-galactosidase synthesis in Escherichia coli. (1959) (6)
- Growth dysregulation in cancer cells. (1994) (6)
- A simplified method of determining the sizes of viruses in impure preparations. (1952) (6)
- ULTRAVIOLET LIGHT INDUCED SPECTRAL CHANGES IN NUCLEOTIDES AND NUCLEIC ACIDS* (1962) (6)
- Canventol inhibits HIV-1 replication by Tat-induced Tar-independent mechanism. (1996) (6)
- ENZYME ACTIVITY AND BACTERIOPHAGE INFECTION (1951) (6)
- Roots: Molecular basis of gene expression: Origins from the Pajama experiment (1985) (6)
- Deoxyribonuclease activity in Escherichia coli K12 (λ) after bacteriophage induction with ultraviolet irradiation (1957) (5)
- Cell Cycle Studies of Mononucleate and Cytochalasin-B-Induced Binucleate Fibroblasts ( nuclear-cytoplasmic interactions / growth regulation ) (5)
- Response : Alternatives to 35 S as a Label for the Differential Display of Eukaryotic Messenger RNA (1995) (5)
- Serum-responsive expression from the murine thymidine kinase promoter is specifically disrupted in a transformed cell line. (1994) (5)
- An artifact in measurement of S phase initiation and its implication for the kinetics of S phase-specific enzyme activities. (1982) (5)
- What Goes Wrong in Cancer (2008) (5)
- Cellular oncogenes, growth factors, and cellular growth control. (1984) (5)
- Cell multiplication editorial overview (1992) (4)
- Detection of eukaryotic cDNA in differential display is enhanced by the addition of E. coli RNA. (2000) (4)
- Isolation and purification of functional total RNA from woody branches and needles of sitka and white spruce. (2000) (4)
- Size and Shape of Blood Group A-Substance (1951) (4)
- The Cold Spring Harbor Laboratory of Quantitative Biology (1963) (4)
- The surface membrane as a regulator of animal cell division (1971) (4)
- On the stability of m-RNA in a polar mutant. (1965) (4)
- Three-Dimensional Drawings: The Architecture of Molecules . Linus Pauling and Roger Hayward. Freeman, San Francisco, Calif., 1964. Unpaged. Plates. $10. (1965) (4)
- The degree of association of some simple antigens. (1949) (4)
- Free Energy and Metabolism (1954) (4)
- Enzymatic activity and bacteriophage infection. III. Increase of desoxyribonuclease. (1953) (4)
- Detection of the level of estrogen receptor and functional variants in human breast cancers by novel assays. (2000) (4)
- Complete genome expression monitoring: The human race (1997) (3)
- Gene photoinactivation in Escherichia coli which contain 5-bromodeoxyuridine-substituted DNA. (1970) (3)
- The study of DNA-repair defects using [125I]iododeoxycytidine incorporation as an assay for the growth of herpes simplex virus. (1983) (3)
- The Biochemical Requirements for Bacterial Division (1974) (3)
- Enhanced synthesis and stabilization of Mr 68 , 000 protein in transformed BALB / c-3 T 3 cells : Candidate for restriction point control of cell growth ( labile protein / two-dimensional electrophoresis / cell cycle / prereplicative phase ) (3)
- Loss of viability and beta-galactosidase-forming ability as a consequence of tritium decay in Escherichia coli. (1963) (3)
- Fluosol-DA/carbogen with lonidamine or pentoxifylline as modulators of alkylating agents in the FSaIIC fibrosarcoma (2004) (3)
- CITRATE TRANSPORT BY BACILLUS SUBTILIS (1972) (3)
- Tumor progression—targets for differential therapy (2006) (3)
- Expression genetics : accelerated and high-throughput methods (1999) (3)
- THE PAJAMA EXPERIMENT (2003) (3)
- Principles and procedures in the isolation of enzymes. (1953) (3)
- Basis of observed resistance of L1210 leukemia in mice: methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, and 1-beta-D-arabinofuranosylcytosine administered in different combinations. (1981) (3)
- The Luria-Latarjet effect studied by T4-lysozyme production. (1968) (2)
- ON THE REGULATION OF EUKARYOTIC CELL GROWTH: AN APPROACH TO THE BEHAVIOR OF NORMAL AND TRANSFORMED CELLS (1981) (2)
- Membranes and the Coordination of Cellular Activities (1971) (2)
- Thymidine kinase transcription is regulated at G 1 / S phase by a complex that contains retinoblastoma-like protein and a cdc 2 kinase ( cell cycle / DNA-binding proteins / inducible DNA-binding activity (2)
- Modification of cell proliferation with inhibitors (1992) (2)
- Pharmacological Interference with DNA Repair (1987) (2)
- Tenidap inhibits replication of the human immunodeficiency virus-1 in cultured cells. (1997) (2)
- Control of metabolic reactions by feedback inhibition. (1971) (2)
- Regulation of active transport. (1967) (2)
- Mechanisms for Control of Enzyme Synthesis and Enzyme Activity in Bacteria (2008) (2)
- Differential Display RT PCR (2002) (2)
- ON TRANSITORY AND PERIODIC SYSTEMS IN BACTERIA (1965) (2)
- Growth Regulation by Transport into Mammalian Cells (1982) (2)
- Interference with DNA repair mechanisms of mammalian cells: cell cycle dependence. (1983) (2)
- Apoptosis in non-proliferating cells: implications for viral infection and tumourigenesis (1998) (2)
- Inhibition of Human Immunodeficiency Virus Type 1 Replication In Vitro by a Novel Combination of Anti-Tat Single-Chain Intrabodies and NFk B Antagonists (1997) (2)
- Normal cells arrest cancer cells in G2. (2003) (2)
- Sensitive assays for detection of lung cancer. Molecular markers in blood samples. (2003) (1)
- Is Elevated through a p53-independent Pathway by Mimosine1 (1996) (1)
- Pentoxifylline trental enhances the antiretroviral activity of didanosine dideoxyinosine ddl (1992) (1)
- Francois Jacob memorial (2013) (1)
- Biomarkers, regerons, and pathways to lethal cancer (2007) (1)
- High-School Students as Laboratory Assistants. (1956) (1)
- Deoxyribonuclease activity in Escherichia coli K12 (lambda) after bacteriophage induction with ultraviolet irradiation. (1957) (1)
- Balb/c 3t3 cells do not all arrest in the first g1 after exposure to growth restrictive conditions. Abstr. (1978) (1)
- Abstract LB-253: Inhibition of stemness by BBI608 is sufficient to suppress cancer relapse and metastasis (2015) (1)
- Hormone-inducible genes in prostate cells. (1997) (1)
- Pentoxifylline trental decreases tumor necrosis factor tnf and hiv replication in patients with aids (1992) (1)
- Can a DNA repair inhibitor block the tumorigenic transformation of normal cells following a genetic insult (1989) (1)
- Epidermal growth factor-induced nuclear factor k B activation : A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells (2000) (1)
- A devious cube of cancer (2008) (1)
- Nuclear factor-K B activation : a molecular therapeutic target for estrogen receptor – negative and epidermal growth factor receptor family receptor – positive human breast cancer (2007) (1)
- Two controls of cell proliferation underlie cancer relapse (2018) (1)
- Bioregulation (2015) (1)
- What Genetics Offers Geobiology (2005) (1)
- Enhancement of brain retinoic acid levels (2007) (1)
- Enhancement by caffeine and 3-aminobenzamide of nitrosoguanidine nuclear fragmentation in hamster cells (1991) (1)
- Misregulated Fate—Cancer (2005) (1)
- Advances in Brief Apoptosis Caused by Chemotherapeutic Inhibition of Nuclear Factor-B Activation 1 (2003) (0)
- The establishment of beta-galactosidase repression in the mating system of Escherichia coli K12. (1966) (0)
- Enhanced synthesis and stabilization of a 68k protein in benzo(a)-pyrene transformed balb/c3t3 cells: a candidate for restriction point control of cell growth. Abstr. (1983) (0)
- Altered nuclear factor interaction with the promoter of the human thymidine kinase gene during the cell cycle (1987) (0)
- Biochemical studies on active transport. (1968) (0)
- Evidence for the Involvement of an Outer Membrane Protein in (2011) (0)
- Letter from Arthur B. Pardee to Joshua Lederberg (1959) (0)
- Control of DNA synthesis in tissue culture cells (2007) (0)
- Erratum: ‘Inhibitor evidence for allosteric interaction in the replitase multienzyme complex’ (1983) (0)
- f 8-Lapachone Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells (0)
- Figure 2.1, [The cell cycle. When a...]. (2000) (0)
- Intracellular pH is increased afterl 1 hamster embryo fibroblasts (Na+/H+ antiporter/growth control) (2016) (0)
- Ektobiology, Growth Control and Cancer (1984) (0)
- CYCLIN E FOR CANCER PROGNOSIS Materials and Methods Western Blot Analysis of Tissue Samples . Snap frozen surgical specimens from patients diagnosed with breast cancer (2007) (0)
- Letter from Arthur B. Pardee to Benno C. Schmidt (1977) (0)
- Use of xanthines for the preparation of medicaments for the inhibition of proliferation of human retroviruses (1991) (0)
- The sixth Sir Hans Krebs lecture: the biochemical requirements for bacterial division. In pursuit of protein X. (1974) (0)
- Solid tumor cancer markers and applications to steroid hormone research. (2001) (0)
- Solutions for cell culture Cell growth and division: A practical approach Edited by R. Baserga. New York: Oxford University Press. (1989). 158 pp. $38.00 (1990) (0)
- Introducing Cell Cycle (2002) (0)
- Captive audience. (1972) (0)
- Ordered Splicing ofThymidine Kinase Pre-mRNAduring the SPhaseoftheCellCycle (1990) (0)
- Update for Cancer Therapy with β-Lapachone (2004) (0)
- Transport and Phospholipid Changes Related to Control of Gsrowth in 3T3 Cells (2008) (0)
- Regulation of the Cell Cycle by Kinases and Cyclins (2020) (0)
- Part I. The degree of association of some simple antigens. Part II. The reactions of synthetic antigens with specifically purified antibodies. Part III. The size and shape of molecules of "A" substance from hog gastric mucin (1947) (0)
- Molecules of Deregulated Cell Cycle Control in Cancer (1994) (0)
- Rambling Thoughts About Doing and Thinking Research (2004) (0)
- Normal Cells Arrest Cancer in G2 (2003) (0)
- Cell Cycle Checkpoints (2002) (0)
- Proteins in five dimensions (1994) (0)
- pU: A New Quantity in Biochemistry (1962) (0)
- Differential Display Method (2007) (0)
- In Vivo and in Vitro Enhanced Antitumor Effects by Pentoxifylline in Human Cancer Cells Treated with Thiotepa 1 (2006) (0)
- Response (1995) (0)
- Expression Genetics of Hormone Dependent Human Tumors (2001) (0)
- High-School Students as Laboratory Assistants (1956) (0)
- [Periodicity in bacterial cell cycles]. (1966) (0)
- Genetics of Sulfate Transport by Salmonella typhimuriuml (0)
- INACTIVATION OF BETA-GALACTOSIDASE INDUCTION BY ULTRAVIOLET LIGHT. (1963) (0)
- Cell Cycles by Lovastatin to Multiple 1 Synchronization of Tumor and Normal Cells from G Updated (2006) (0)
- Sensitive Assays for Detection of Lung Cancer (2003) (0)
- The Genetic Control and Cytoplasmic Expression of 'Inducibility' in the synthesis of B-galactosidase" (1959), by Arthur B. Pardee, Francois Jacob, and Jacques Monod (2017) (0)
- Procedes de clonage d'arn messager (1993) (0)
- Cancer Detection and Biomarkers (2008) (0)
- Down-regulation of a homocysteine-induced novel gene in metastatic human colon cancer (1998) (0)
- The S phase: beginning, middle, and end: a perspective. (1998) (0)
- Book Review:Regulation of Nucleic Acid and Protein Biosynthesis. V. V. Koningsberger, L. Bosch (1968) (0)
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