Arthur Weiss

Q: What Schools Are Affiliated With Arthur Weiss

Arthur Weiss is affiliated with the following schools: Washington University in St. Louis, University of California, Berkeley, University of Florida, Stanford University, University of Chicago, Johns Hopkins University, University of Copenhagen, University of California, San Francisco

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Arthur Weiss

Biology

#2861

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#4469

Historical Rank

Immunology

#117

World Rank

#124

Historical Rank

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Biology

Arthur Weiss 's Degrees

Bachelors Biology University of California, Berkeley
PhD Immunology Stanford University

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Why Is Arthur Weiss Influential?

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According to Wikipedia, Arthur Weiss is an American Immunologist who is currently an Ephraim P. Engleman Distinguished Professor of Medicine and a professor of microbiology and immunology at the University of California, San Francisco. He has been a member of the National Academy of Sciences since 2003. He specializes in studying T cell development and immune responses. His research focus has recently been shifted towards studying autoimmune diseases such as lupus and rheumatoid arthritis. He is also a Howard Hughes Medical Investigator, a title he has held since 1982.

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Arthur Weiss 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Signal transduction by lymphocyte antigen receptors (1994) (2190)
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor (1992) (1040)
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. (2004) (973)
ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain (1992) (973)
CD45: a critical regulator of signaling thresholds in immune cells. (2003) (828)
Induction of NF-κB by the Akt/PKB kinase (1999) (800)
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. (1994) (753)
The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways (1991) (749)
Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. (1991) (696)
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation (2004) (671)
Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse” (2011) (663)
Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. (2002) (578)
The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level. (1984) (572)
Signal transduction by the TCR for antigen. (2000) (557)
The role of the T3/antigen receptor complex in T-cell activation. (1986) (541)
Jurkat T cells and development of the T-cell receptor signalling paradigm (2004) (523)
The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. (1994) (523)
LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway (1998) (514)
T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases (1993) (512)
Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. (1994) (500)
Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line (1984) (478)
ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. (1994) (474)
CD28 Costimulation: From Mechanism to Therapy. (2016) (468)
Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. (1998) (462)
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway (1990) (435)
Switching Signals On or Off by Receptor Dimerization (1998) (416)
Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. (1984) (401)
Induction of NF-kappaB by the Akt/PKB kinase. (1999) (392)
Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells (2009) (384)
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines (2001) (376)
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. (1996) (363)
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. (1992) (342)
The immunological synapse and CD28-CD80 interactions (2001) (341)
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes (1996) (341)
ZAP-70: an essential kinase in T-cell signaling. (2010) (314)
Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain (1993) (309)
αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases (1996) (289)
Insights into the initiation of TCR signaling (2014) (288)
TCR Signaling: Mechanisms of Initiation and Propagation. (2017) (285)
The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 (2003) (284)
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase (1993) (282)
Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer (1985) (282)
Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms (2002) (281)
Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. (1998) (280)
Endogenous antigen tunes the responsiveness of naive B cells but not T cells (2012) (278)
Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism (1998) (276)
ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. (2005) (273)
The Syk family of protein tyrosine kinases in T‐cell activation and development (1998) (272)
An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity (2000) (269)
ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. (1994) (269)
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. (1994) (266)
Cell surface molecules and early events involved in human T lymphocyte activation. (1987) (265)
T cell antigen receptor signal transduction. (1997) (249)
CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites (1997) (244)
Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes (1987) (238)
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes (1987) (230)
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C (1996) (229)
Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70 (2007) (222)
CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. (1993) (219)
A Diacylglycerol-Protein Kinase C-RasGRP1 Pathway Directs Ras Activation upon Antigen Receptor Stimulation of T Cells (2005) (219)
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice (2008) (214)
T cell receptor signalling. (2001) (213)
The structure, regulation, and function of ZAP‐70 (2009) (208)
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation (1994) (206)
It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation (2002) (202)
The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium. (1985) (201)
Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT (2001) (194)
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape (2013) (191)
A functional T-cell receptor signaling pathway is required for p95vav activity (1995) (190)
Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. (2002) (188)
Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus (1986) (185)
Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. (1985) (180)
Identification of the Minimal Tyrosine Residues Required for Linker for Activation of T Cell Function* (2001) (179)
Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. (1987) (177)
Localization of LAT in Glycolipid-enriched Microdomains Is Required for T cell Activation* (1999) (177)
Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. (2000) (176)
Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling (1997) (173)
Unusual Interplay of Two Types of Ras Activators, RasGRP and SOS, Establishes Sensitive and Robust Ras Activation in Lymphocytes (2007) (170)
Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. (1999) (166)
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. (1998) (165)
Early signal transduction by the antigen receptor without commitment to T cell activation. (1988) (163)
Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-κB-Dependent Transcription (2002) (161)
The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase (1994) (161)
Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. (2002) (159)
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm (2013) (158)
Signal transduction events leading to T-cell lymphokine gene expression. (1993) (157)
Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer. (1986) (157)
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. (2007) (154)
Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility. (1972) (154)
Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. (1986) (152)
Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. (2008) (151)
Negative Regulation of Hif1a Expression and TH17 Differentiation by Hypoxia Regulated miR-210 (2014) (150)
Identification and sequence of a fourth human T cell antigen receptor chain (1987) (149)
ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. (2008) (146)
Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex (1987) (145)
The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation (1993) (144)
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer (1987) (141)
Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. (1994) (141)
The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. (1996) (139)
A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor (1987) (139)
Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. (2012) (139)
A Nck‐Pak1 signaling module is required for T‐cell receptor‐mediated activation of NFAT, but not of JNK (1998) (138)
A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras (2000) (137)
The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. (1994) (136)
Antiproliferative action of interferon-α requires components of T-cell-receptor signalling (1997) (136)
Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor. (1987) (136)
Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28 (1992) (135)
Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases (2005) (134)
The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase (2000) (134)
Lymphocytes with a complex: adapter proteins in antigen receptor signaling. (2000) (132)
PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background1 (2009) (131)
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis (2009) (131)
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation (2014) (127)
Linker for Activation of T Cells, ζ-Associated Protein-70, and Src Homology 2 Domain-Containing Leukocyte Protein-76 are Required for TCR-Induced Microtubule-Organizing Center Polarization1 (2003) (126)
Overview of the Alliance for Cellular Signaling (2002) (125)
The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. (1988) (124)
A CD45 Polymorphism Associated with Multiple Sclerosis Disrupts an Exonic Splicing Silencer* (2001) (124)
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells. (2013) (122)
Differential requirements for ZAP-70 in TCR signaling and T cell development. (1998) (121)
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. (2000) (120)
Bacterial Virulence Proteins as Tools to Rewire Kinase Pathways in Yeast and Immune Cells (2012) (117)
T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells. (1985) (117)
The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant. (1994) (116)
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells (2017) (115)
A PAK1–PIX–PKL complex is activated by the T‐cell receptor independent of Nck, Slp‐76 and LAT (2001) (114)
The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. (2001) (113)
Src-like Adaptor Protein (Slap) Is a Negative Regulator of T Cell Receptor Signaling (2000) (113)
The catalytic activity of the CD45 membrane‐proximal phosphatase domain is required for TCR signaling and regulation. (1994) (113)
The Vav Binding Site (Y315) in ZAP-70 Is Critical for Antigen Receptor–mediated Signal Transduction (1997) (112)
Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes* (2001) (112)
CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation (1992) (108)
T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression (2003) (108)
A Guanine Nucleotide Exchange Factor-independent Function of Vav1 in Transcriptional Activation* (2000) (106)
Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes (1995) (106)
The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit (1995) (105)
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling (1996) (105)
Stimulation of the phosphatidyl-inositol pathway can induce T-cell activation (1990) (104)
SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction (*) (1996) (102)
Expression and Function of Tec, Itk, and Btk in Lymphocytes: Evidence for a Unique Role for Tec (2004) (98)
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling (2003) (97)
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT (2018) (97)
NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells. (1996) (97)
The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes (2008) (97)
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70 (1996) (96)
Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila (2009) (96)
Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex (2006) (95)
Multiple kinases mediate T-cell-receptor signaling. (1995) (95)
The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes. (1995) (91)
c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1 (1996) (89)
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. (2010) (88)
Characterization of an expressed CDS-associated Ti γ-chain reveals Cγ domain polymorphism (1987) (88)
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity (2010) (87)
Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase Cγ1 Phosphorylation (2001) (85)
Transmembrane signalling by the T3-antigen receptor complex. (1985) (83)
Distinct roles for Syk and ZAP-70 during early thymocyte development (2007) (83)
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity (2009) (83)
Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation (2015) (81)
ZAP-70 in Signaling, Biology, and Disease. (2018) (80)
The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. (2002) (80)
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker (2013) (79)
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. (2001) (79)
Stim1, PKCδ and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development (2011) (78)
Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling (2011) (78)
Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs. (1998) (78)
IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level (2017) (77)
Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1 (2005) (75)
Src-like adaptor protein down-regulates T cell receptor (TCR)–CD3 expression by targeting TCRζ for degradation (2005) (75)
Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases (2013) (74)
Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line. (1992) (73)
Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia (2015) (72)
Delta is the C x-gene product in the γ/δ antigen receptor of dendritic epidermal cells (1987) (72)
Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. (2006) (71)
Structure and function of the T cell antigen receptor. (1990) (71)
Origin of the sharp boundary that discriminates positive and negative selection of thymocytes (2009) (70)
CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation (1995) (70)
Macrophages suppress CTL generation in rat mixed leukocyte cultures. (1977) (70)
Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation (1997) (69)
PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients (2001) (69)
Molecular and genetic insights into T cell antigen receptor structure and function. (1991) (68)
alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. (1996) (68)
Distinct T Cell Developmental Consequences in Humans and Mice Expressing Identical Mutations in the DLAARN Motif of ZAP-701 (2001) (68)
Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation (2004) (67)
Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling (2016) (67)
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation (2018) (67)
It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation. (2002) (65)
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70 (2016) (65)
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (65)
Caspase-mediated Cleavage of Hematopoietic Progenitor Kinase 1 (HPK1) Converts an Activator of NFκB into an Inhibitor of NFκB* (2001) (64)
Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. (1999) (63)
Molecular diversity of the human T-gamma constant region genes. (1987) (62)
T Cell Receptor Engagement Leads to Phosphorylation of Clathrin Heavy Chain during Receptor Internalization (2004) (61)
SHIP Family Inositol Phosphatases Interact with and Negatively Regulate the Tec Tyrosine Kinase* (2004) (60)
Requirements for triggering of lysis by cytolytic T lymphocyte clones. (1987) (59)
The juxtamembrane wedge negatively regulates CD45 function in B cells. (2005) (59)
Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling*S⃞ (2008) (58)
Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling (2013) (57)
Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor (2015) (57)
Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants. (1989) (57)
Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development (2014) (55)
Differential effect of cyclosporin A on activation signaling in human T cell lines. (1986) (54)
CD45 functions as a signaling gatekeeper in T cells (2019) (54)
Synergistic Assembly of Linker for Activation of T Cells Signaling Protein Complexes in T Cell Plasma Membrane Domains* (2003) (54)
Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens (1980) (53)
The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor. (1992) (53)
Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. (2011) (53)
SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling (2011) (52)
Antiproliferative action of interferon-alpha requires components of T-cell-receptor signalling. (1997) (51)
Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. (1987) (51)
Nocodazole Inhibits Signal Transduction by the T Cell Antigen Receptor* (1998) (50)
Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. (1998) (49)
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate (2010) (47)
Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns (2014) (47)
Signal transduction by the T cell antigen receptor. (1991) (47)
Differential Expression of the ARF GAP Genes GIT1 and GIT2 in Mouse Tissues (2007) (47)
Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner (2006) (46)
Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival (2011) (46)
Stimulation of the phosphatidylinositol pathway can induce T-cell activation. (1990) (46)
Interdomain B in ZAP-70 Regulates but Is Not Required for ZAP-70 Signaling Function in Lymphocytes (1999) (45)
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway (2015) (45)
Regulation of thymocyte positive selection and motility by GIT2 (2010) (44)
Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination (2019) (44)
Adaptation by naïve CD4+ T cells to self-antigen–dependent TCR signaling induces functional heterogeneity and tolerance (2019) (44)
T cells: getting a GRP on Ras (2000) (44)
A Proline-Rich Motif in the C Terminus of Akt Contributes to Its Localization in the Immunological Synapse1 (2004) (43)
Src-Like Adaptor Protein Regulates B Cell Development and Function (2006) (43)
SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking (2009) (43)
Inhibition of Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full T cell receptor signaling (2013) (42)
The lysine residue in the membrane-spanning domain of the beta chain is necessary for cell surface expression of the T cell antigen receptor (1988) (42)
Alternative splicing of CD45: the tip of the iceberg. (2008) (41)
Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen. (1978) (41)
The membrane environment can promote or suppress bistability in cell signaling networks. (2012) (39)
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4 (2006) (39)
Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development (1997) (39)
At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor. (1988) (38)
The PreT Cell Receptor ( TCR ) Complex is Functionally Coupled to the TCR-~ Subunit (1995) (38)
Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (2014) (38)
A transferrin receptor antibody represents one signal for the induction of IL 2 production by a human T cell line. (1986) (38)
Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen (2018) (37)
CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic (2019) (37)
Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number. (1991) (37)
A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. (2017) (37)
Small molecule inhibition of Csk alters affinity recognition by T cells (2015) (37)
Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL (2014) (37)
Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. (2011) (36)
The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence. (2007) (36)
The role of protein kinase C in the regulation of extracellular signal‐regulated kinase by the T cell antigen receptor (1994) (35)
Syk Mutation in Jurkat E6-derived Clones Results in Lack of p72syk Expression (*) (1995) (35)
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response (2009) (35)
The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions. (2019) (34)
Regulation of Src Family Kinases Involved in T Cell Receptor Signaling by Protein-tyrosine Phosphatase CD148* (2011) (34)
ZAP-70 Protein Tyrosine Kinase Is Constitutively Targeted to the T Cell Cortex Independently of its SH2 Domains (1997) (34)
The Src-Like Adaptor Protein Regulates GM-CSFR Signaling and Monocytic Dendritic Cell Maturation (2011) (33)
Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor Signaling In Vivo (2016) (31)
Regulatory mechanisms for receptor protein tyrosine phosphatases. (2001) (31)
Acquired immunodeficiency syndrome: epidemiology, virology, and immunology. (1985) (31)
The right team at the right time to go for a home run: tyrosine kinase activation by the TCR (2010) (30)
Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. (2018) (30)
Distinct epitopes on the T cell antigen receptor of HPB-ALL tumor cells identified by monoclonal antibodies. (1986) (30)
Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes (2009) (29)
Itk and Fyn Make Independent Contributions to T Cell Activation (1997) (28)
Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization (2018) (28)
Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain. (1990) (27)
Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. (2001) (27)
Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3 (1991) (27)
Regulated Expression of the Receptor-Like Tyrosine Phosphatase CD148 on Hemopoietic Cells1 (2004) (27)
Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases (2007) (26)
The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. (2013) (26)
Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFkappaB into an inhibitor of NFkappaB. (2001) (26)
LynA regulates an inflammation-sensitive signaling checkpoint in macrophages (2015) (26)
The regulation of T-cell antigen receptor signal transduction function. (1991) (26)
Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems. (2009) (26)
An extracatalytic function of CD45 in B cells is mediated by CD22 (2015) (25)
Basal LAT-diacylglycerol-RasGRP1 Signals in T Cells Maintain TCRα Gene Expression (2011) (25)
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-yl (25)
How the T cell signaling network processes information to discriminate between self and agonist ligands (2020) (24)
Antigen receptor signaling in the rheumatic diseases (2009) (24)
Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. (1987) (23)
TCR- and IL-1-mediated co-stimulation reveals an IL-4-independent way of Th2 cell proliferation. (1996) (23)
Production and characterization of monoclonal antibodies specific for the murine T cell receptor ζ chain (1994) (23)
A CRISPR-Based Toolbox for Studying T Cell Signal Transduction (2016) (23)
Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. (2011) (22)
Ca2+-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells (2011) (20)
Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses (2009) (20)
Cytolytic T lymphocyte clones. (1982) (20)
Protein Kinase Cδ Promotes Transitional B Cell-Negative Selection and Limits Proximal B Cell Receptor Signaling To Enforce Tolerance (2014) (19)
Anti-peptide Antibodies Detect Conformational Changes of the Inter-SH2 Domain of ZAP-70 Due to Binding to the ζ Chain and to Intramolecular Interactions* (1998) (19)
Molecular and genetic insights into T cell antigen receptor signal transduction. (1994) (19)
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis (2018) (18)
Phee, H. , Abraham, R.T. & Weiss, A. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat. Immunol. 6, 608-617 (2005) (18)
IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells (2017) (17)
Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction. (1981) (17)
The initiation of human T lymphocyte activation. (1988) (16)
T cell antigen receptor signal transduction. Curr Opin Cell Biol (1997) (16)
Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. (2015) (15)
Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. (1987) (15)
B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency (2008) (14)
STIM 1 , PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development (14)
The role of the antigen receptor/T3 complex in T-cell activation. (1987) (13)
Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells. (2016) (13)
Zap70 Is Essential for Long-Term Survival of Naive CD8 T Cells (2014) (13)
The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity (2013) (13)
The role of T3 in the activation of human T cells (1984) (12)
Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain. (1992) (12)
New clues about T-cell antigen receptor complex function. (1988) (12)
Expression and function of cd3 on murine thymocytes (1988) (12)
Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness (2017) (12)
The gamma T-cell antigen receptor (1987) (12)
The adapter proteins LAT and SLP-76 are required for T-cell activation. (1999) (11)
Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45. (2013) (11)
PTPN 22 Deficiency Cooperates with the CD 45 E 613 R Allele to Break Tolerance on a Non-Autoimmune Background 1 (2009) (11)
Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen (2017) (10)
A genetically selective inhibitor reveals a ZAP-70 catalytic-independent function in TREG cells (2010) (10)
Kinases and phosphatases of the immune system (2009) (10)
TCR Signal Transduction: Opening the Black Box1 (2009) (10)
Twisting tails exposed (2005) (9)
Ligand-induced association between the T-cell antigen receptor and two glycoproteins. (1989) (9)
Molecular and Genetic Insights into T‐Cell Antigen Receptor Signaling (1995) (9)
Stim1, PKC{delta} and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development (2011) (8)
Cbl-b deficiency prevents functional but not phenotypic T cell anergy (2021) (8)
Unbiased Modifier Screen Reveals That Signal Strength Determines the Regulatory Role Murine TLR9 Plays in Autoantibody Production (2015) (7)
Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level” (2015) (7)
Halting the March of the Immune Defenses (1998) (7)
ZAP70, too little, too much can lead to autoimmunity (2021) (6)
Regulation of cell growth and activation (1989) (6)
Molecular and genetic insights into the role of protein tyrosine kinases in T cell receptor signaling. (1995) (6)
Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads (2021) (6)
Generation and Analysis of a T‐Lymphocyte Somatic Mutant for Studying Molecular Aspects of Signal Transduction by the Antigen Receptor a (1988) (6)
Adapting T Cell Receptor Ligand Discrimination Capability via LAT (2021) (6)
Lymphocyte activation and effector functions Turning lymphocytes on and off (1998) (6)
CHARACTERISTICS AND STABILIZATION OF DNAASE-SENSITIVE PROTEIN SYNTHESIS (2001) (5)
Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb (2021) (5)
A transfected human muscarinic receptor fails to substitute for the T cell antigen receptor complex in CD2-initiated signal transduction. (1990) (5)
Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway (2021) (5)
Correction: Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia (2016) (4)
Regions of the T Cell Receptor a and 0 Chains that Are Responsible for Interactions with CD3 (2003) (4)
Function of the antigen receptor in T cell activation. (1988) (4)
Delta is the Cx-gene product in the gamma/delta antigen receptor of dendritic epidermal cells. (1987) (3)
Signal Transduction by Lymphocyte Antigen Receptors Review (1994) (3)
Suppression of adult rat lymphoid proliferative responses by homologous neonatal serum. (1977) (3)
A Clue to Antigen Receptor Tails (2014) (3)
Naïve arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen (2022) (3)
Discovering the TCR beta-chain by subtraction. (2005) (3)
Cell Activation: Genetic Approaches (1991) (3)
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands (2021) (3)
Itk promotes the integration of TCR and CD28 costimulation, through its direct substrates, SLP-76 and Gads (2020) (3)
Surface chimeric receptors as tools in study of lymphocyte activation. (2000) (2)
A dominant mechanism coordinately suppresses the expression of Th2 lymphokines. (1997) (2)
1 INHIBITION OF ZAP-70 KINASE ACTIVITY VIA AN ANALOG-SENSITIVE ALLELE BLOCKS T CELL RECEPTOR AND CD 28 SUPERAGONIST SIGNALING (2008) (2)
ZAP-70 Enhances IgM Signaling in Chronic Lymphocytic Leukemia Cells Independent of Its Tyrosine Kinase Activity. (2006) (2)
Discovering the TCR β-Chain by Subtraction (2005) (2)
Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways (2016) (2)
Author response: Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation (2014) (2)
THE ROLE OF PROTEIN TYROSINE KINASES AND PROTEIN TYROSINE PHOSPHATASES IN T CELL ANTIGEN RECEPTOR (1994) (2)
Lymphocyte signaling: a Tuscan affair (2011) (2)
Production and characterization of monoclonal antibodies specific for the murine T cell receptor zeta chain. (1994) (2)
Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation (1988) (2)
Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development (2015) (2)
Opposing functions of Zap70 for immunity and tolerance titrate differentially in response to inherited single nucleotide substitutions (2011) (1)
production: implications for multiple myeloma progression Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 (2013) (1)
Chapter 95 – CD45 (2010) (1)
Faculty Opinions recommendation of T cell cytolytic capacity is independent of initial stimulation strength. (2018) (1)
A chemical-genetic approach to inhibit Csk activates T cells independently of the T cell receptor (35.4) (2009) (1)
Pillars article: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 1994. 263: 1136-1139. (2014) (1)
The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P2 replenishment in response to TCR signaling during T cell development and survival (2022) (1)
HemopoieticTyrosine Phosphatase CD 148 on Regulated Expression of the Receptor-Like (2004) (1)
Signal transduction. Zapping tandem SH2 domains. (1995) (1)
Minireview Signal Transduction: A Tale of Tails and Cytoplasmic Protein-Tyrosine Kinases (1993) (1)
The lck SH2 domain is required for signal transduction through the T cell antigen receptor and mediates association of lck with the ZAP-70 protein tyrosine kinase (1995) (1)
platelet activation and thrombosis The tyrosine phosphatase CD148 is an essential positive regulator of (2009) (1)
A new medical therapy for Cushing disease (2011) (1)
Requirements for the triggering of lysis by cloned murine cytolytic T lymphocytes (CTL) (1986) (1)
Lymphocyte signaling (SY4-1) Chairpersons: Tomohiro Kurosaki, Doreen Cantrell (2010) (0)
Frank W. Fitch, M.D. Ph.D., 1929–2021 (2021) (0)
The Initiation of Human T Lymphocyte Activation (Part 1 of 2) (1988) (0)
Kinases & phosphatasses of the immune system (2009) (0)
Faculty Opinions recommendation of Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division. (2018) (0)
Abstract Submitted for the MAR16 Meeting of The American Physical Society Base-by-Base Counting of Nucleotide Incorporations by DNA Polymerase MACKENZIE W. TURVEY, O. TOLGA GUL, (2015) (0)
CHAPTER 4 – REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR (1988) (0)
The Initiation of Human T Lymphocyte Activation (Part 2 of 2) (1988) (0)
Tolerance B Cell Receptor Signaling To Enforce ProximalCell-Negative Selection and Limits Promotes Transitional B δ Protein Kinase C (2014) (0)
Generation and characterization of GIT1 and GIT2 deficient mice (87.18) (2007) (0)
Investigation of Novel Zap-70 Functionality in T Cell Signaling Pathways using Computational Modeling (2014) (0)
Mutations in the DLAARN Motif of ZAP-70 in Humans and Mice Expressing Identical Distinct T Cell Developmental Consequences (2000) (0)
Declined Presentation: A T cell receptor signal threshold determines positive selection (2014) (0)
Role of GIT2 in T cell migration and development (95.8) (2009) (0)
Tony Pawson: Modular protein domains and the links to intracellular signaling (2013) (0)
Immunological Synapse Akt Contributes to Its Localization in the A Proline-Rich Motif in the C Terminus of (2004) (0)
CD45specifically modulates binding ofLcktoa phosphopeptide encompassing thenegative regulatory tyrosine ofLck (1993) (0)
The Phenotypic Consequences of an Activating Mutation in the Juxtamembrane Wedge of CD45 Is Sensitive to Genetic Modifiers. (2006) (0)
Characterization of platelet-activating factor receptors on canine T lymphocytes. (1993) (0)
Differential regulation of cytotoxicity and cytokine production via surface receptors in CD45-deficient natural killer cells (B185) (2007) (0)
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology. (2023) (0)
Dimerization of the CD45 RPTPase inhibits its function in vivo and is necessary in order to prevent autoimmunity (2001) (0)
Materials and Methods (1999) (0)
DEPENDENCE OF CD2 ON CD3/TI FOR TRANSMEMBRANE SIGNALING (1988) (0)
A novel analog-sensitive allele of Csk reveals its kinase-independent role in the regulation of T cell receptor signaling (109.35) (2011) (0)
Regulation of thymocyte positive selection and motility by GIT 2 Citation (2013) (0)
Bruton's Tyrosine Kinase Membrane Dynamics and Signaling (2020) (0)
Activation of the IL-2 promoter and the RE/AP composite element in response to superantigen requires CD28 costimulation (1998) (0)
Molecular Dissection of T-Cell Antigen Receptor Signal Transduction (1993) (0)
Stim1 sets a threshold for activation of a pro-apoptotic Erk pathway in B cells (84.21) (2009) (0)
Synergy between the T3/Ti complex and Tp44 in human T cell activation (1986) (0)
Productive HIV-1infection ofmacrophages restricted tothecell fraction withproliferative capacity (1994) (0)
A Point Mutation in the Juxtamembrane Wedge of CD45 Impacts Myeloid Development and Generates a Novel Model for Hemophagocytic Disorders in the Context of a MHC I-Restricted Transgene. (2007) (0)
Antigen receptor signaling: a Tuscan affair (2012) (0)
Regulatory Mechanisms for Receptor Protein Tyrosine Phosphatases (2001) (0)
Protection From Airway Hyperresponsiveness In Mice Lacking The Receptor-Like Protein Tyrosine Phosphatase CD148 (2012) (0)
Upregulation of AP-1 activity by C-rel (1996) (0)
Dendritic Cell Maturation GM-CSFR Signaling and Monocytic The Src-Like Adaptor Protein Regulates (2011) (0)
Modelling the Mechanics of the Circulation: Blood Rheology and Atherosclerosis (2014) (0)
Abstract A074: A Zap70-dependent negative feedback loop governs Lck activation by CD45 (2016) (0)
Generation and characterization of GIT1 and GIT2 deficient mice (2007) (0)
Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function (2010) (0)
Titration of CD45 expression regulates sequential tolerance checkpoints during B cell development (45.2) (2011) (0)
Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia (2015) (0)
Cyclosporin A does not block the phorbol ester - protein kinase C regulated pathway of T cell activation (1986) (0)
Impact of TLR9 on hyper-responsive ITAM signaling in a mouse model of SLE (47.24) (2011) (0)
Identifying ZAP-70 kinase-dependent and -independent functions in T cells using a chemical genetic approach (35.5) (2009) (0)
Tyrosine Kinase Expression for the Down-Regulation of Syk Protein PreT Cell Receptor Signals Are Responsible (1999) (0)
Author response: Small molecule inhibition of Csk alters affinity recognition by T cells (2015) (0)
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells (2022) (0)
Title An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (0)
Faculty Opinions recommendation of Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells. (2018) (0)
Author response: Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb (2021) (0)
Title Capitalizing on opportunities and changing course : An experimental cell line model for T cell activation revealed a two signal model for Interleukin 2 transcript accumulation (2015) (0)
A genetically selective inhibitor reveals ZAP-70 kinase-dependent checkpoints in T cell development (64.15) (2011) (0)
SLE and other connective tissue diseases (animal models) (PP-017) (2010) (0)
An allelic series of CD45 dosages uncouples basal and inducible TCR signaling during thymic development (84.13) (2009) (0)
Mice Lacking The Receptor-Like Protein Tyrosine Phosphatase CD148 Are Protected From Bleomycin Induced Pulmonary Fibrosis (2012) (0)
CD4+ T cells are more sensitive to inhibition of TCR signaling under Th17 polarizing conditions (2020) (0)
Review Antigen receptor signaling in the rheumatic diseases (2009) (0)
Large Scale Transient Gene Expression in Mammalian Cells (1998) (0)
Explore new cancer immunotherapy targets in T cell signaling pathway using proteomic and genetic approaches (2019) (0)
The tyrosine kinase PYK2 integrates TCR and LFA-1 signaling in CD8 T cells to promote effector versus memory fate (83.21) (2009) (0)
Digital signaling, signal filters and central tolerance in thymocytes (2009) (0)
Author response: An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor (2016) (0)
Signaling and T Cell Development Differential Requirements for ZAP-70 in TCR (1998) (0)
Small molecule inhibition of ZAP‐70 kinase activity (2006) (0)
Abstract B042: Regulation of Lck activity by a cryptic phosphosite (2016) (0)
CHAPTER 114 – CD45 (2003) (0)
Basal TCR signaling drives the functional heterogeneity of naïve CD4+ T cells (2020) (0)
Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation (2015) (0)
Role of the receptor-like protein tyrosine phosphatase CD148 in the T cell-independent antibody response (109.12) (2011) (0)
Receptor Like Tyrosine Phosphatases CD45 and CD148 Regulate Integrin- and GPCR-Mediated Pathways in Murine Neutrophils (135.18) (2009) (0)
Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase C g 1 Phosphorylation (2001) (0)
chronic lymphocytic leukemia ZAP-70 enhances IgM signaling independent of its kinase activity in (2013) (0)
Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness (2023) (0)
Faculty Opinions recommendation of PTPN2 regulates T cell lineage commitment and αβ versus γδ specification. (2017) (0)
Brief Definitive Report Reconstitution of T Cell Receptor Signaling in Zap-70-deficient Cells by Retroviral Transduction of the Zap-70 Gene Summal-y (0)
Chains for chimeric receptor-associated signal transduction pathways (1991) (0)
The phosphatidylinositol-transfer protein Nir3 modulates T cell development and function (2022) (0)
Science Signaling Podcast: 1 January 2013 (2013) (0)
A Phosphosite within the S H 2 Domain of Lck Regulates Its Activation by CD 45 Graphical Abstract (2017) (0)
Overcoming inhibitory constraints to TCR signaling by targeting the pH-sensitive phosphatase suppressor of T-cell receptor signaling 1 (STS1) (2022) (0)
- Zap 70: Zap 70 protein-tyrosine kinase (vertebrates) (1995) (0)
Signal Transduction by T- and B-Lymphocyte Antigen Receptors (2013) (0)
Up-Regulation of RE/AP Promoter Activation: Requirement for CD28 Cells and AP-1 Are Insufficient for IL-2 Cutting Edge: Nuclear Factor of Activated T (1998) (0)
CD11blo Gr1+ osteoclast precursors are increased in inflammatory arthritis and have myeloid derived suppressor cell function. (148.1) (2011) (0)
Akt-Dependent Phosphorylation Speciﬁcally Regulates Cot Induction of NF- (cid:2) B-Dependent Transcription (2002) (0)
Assembly and levels of P-TEFb depend on reversible phosphorylation of cyclinT1 (2021) (0)
The phosphatase CD 148 promotes airway hyperresponsiveness through SRC family kinases (2018) (0)
Chimeric chains for transduction of receptor-associated signaling pathways (1991) (0)
Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia (2015) (0)
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function (2023) (0)
The phosphatidinositol-transfer protein Nir3 is a modulator of T cell development (2020) (0)
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT (2018) (0)

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