Arun Kumar Ghosh

Arun Kumar Ghosh's AcademicInfluence.com Rankings

Arun Kumar Ghosh

Chemistry

#2771

World Rank

#3729

Historical Rank

Organic Chemistry

#423

World Rank

#497

Historical Rank

chemistry Degrees

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Chemistry

Arun Kumar Ghosh's Degrees

Masters Chemistry University of Calcutta
Bachelors Chemistry University of Calcutta

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Arun Kumar Ghosh's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

C 2-Symmetric chiral bis(oxazoline)-metal complexes in catalytic asymmetric synthesis. (1998) (534)
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication (2008) (397)
Organic Carbamates in Drug Design and Medicinal Chemistry (2015) (391)
Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro (2003) (337)
Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases (2010) (287)
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS. (2016) (286)
Developing β‐secretase inhibitors for treatment of Alzheimer’s disease (2012) (233)
Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. (2008) (230)
BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease. (2014) (230)
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. (2002) (219)
High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains. (2004) (210)
Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase) (2001) (199)
Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). (2000) (199)
Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics (2020) (194)
Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV. (2007) (179)
β-Secretase as a therapeutic target for Alzheimer’s disease (2008) (178)
Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3† (2002) (155)
Total Synthesis of (±)-Ginkgolide B. (1988) (143)
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. (2006) (139)
Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization* (2007) (136)
Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. (2006) (134)
Enhancing Protein Backbone Binding—A Fruitful Concept for Combating Drug‐Resistant HIV† (2012) (128)
A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site (2002) (128)
Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. (2006) (126)
Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. (2010) (123)
Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114). (2004) (120)
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. (2005) (116)
Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. (2019) (109)
Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. (2009) (106)
Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly (2006) (106)
Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors (2008) (106)
Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV (2015) (105)
Bis‐Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance (2006) (99)
In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors (2004) (94)
Atomic resolution crystal structures of HIV‐1 protease and mutants V82A and I84V with saquinavir (2007) (91)
Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors (2007) (90)
Diastereofacial Selection in Nitrile Oxide Cycloaddition Reactions. The Anti-Directing Effect of an Allylic Oxygen and Some New Results on the Ring Metalation of Isoxazolines. A Synthesis of (±)-Blastmycinone. (1984) (90)
RING-CLOSING METATHESIS STRATEGY TO UNSATURATED γ- AND δ-LACTONES: SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS. (1998) (89)
In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors (2010) (87)
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication (2021) (86)
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. (2007) (86)
N,N'-Disuccinimidyl Carbonate: A Useful Reagent for Alkoxycarbonylation of Amines. (1992) (85)
Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P′2-ligands (2006) (85)
Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. (2008) (84)
Syntheses of FDA Approved HIV Protease Inhibitors. (2002) (82)
Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. (2008) (80)
Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase. (2008) (77)
Structure-based design of cycloamide–urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase) (2005) (72)
Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance (2014) (71)
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro) (2015) (71)
Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). (2005) (69)
Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously. (2004) (69)
Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL) IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS* (2015) (68)
Synthesis of Enantiomerically Pure Anti-Aldols: A Highly Stereoselective Ester-Derived Titanium Enolate Aldol Reaction. (1996) (67)
Beta-secretase as a therapeutic target for inhibitor drugs. (2002) (67)
A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant (2014) (66)
Diastereoselection in Intermolecular Nitrile Oxide Cycloaddition (NOC) Reactions: Confirmation of the "Anti-Periplanar Effect" through a Simple Synthesis of 2-Deoxy-d-ribose†. (1982) (64)
Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages (2016) (64)
Enantioselective total synthesis of (+)-amphidinolide t1. (2003) (64)
Conformationally Constrained Bis(oxazoline) Derived Chiral Catalyst : A Highly Effective Enantioselective Diels-Alder Reaction. (1996) (63)
A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro (2007) (63)
Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation. (2011) (63)
P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines. (2009) (63)
High-yield synthesis of fluorinated benzothiazolyl sulfones: general synthons for fluoro-julia olefinations. (2006) (60)
Enantioselective total synthesis of (-)-zampanolide, a potent microtubule-stabilizing agent. (2011) (60)
Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir (2014) (60)
Palladium-catalyzed synthesis of N-aryloxazolidinones from aryl chlorides. (2003) (58)
Total synthesis of (-)-platensimycin, a novel antibacterial agent. (2009) (58)
Altered HIV-1 Gag Protein Interactions with Cyclophilin A (CypA) on the Acquisition of H219Q and H219P Substitutions in the CypA Binding Loop* (2006) (57)
Coherence between Cellular Responses and in Vitro Splicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs* (2013) (57)
Memapsin 2 (beta-secretase) inhibitors: drug development. (2008) (56)
Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism (2013) (56)
Aspartic acid proteases as therapeutic targets (2010) (55)
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants. (2017) (55)
Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies. (2009) (54)
SYNTHETIC STUDIES OF ANTITUMOR MACROLIDE LAULIMALIDE: ENANTIOSELECTIVE SYNTHESIS OF THE C3-C14 SEGMENT BY A CATALYTIC HETERO DIELS-ALDER STRATEGY. (1997) (54)
SYNTHESIS AND OPTICAL RESOLUTION OF HIGH AFFINITY P2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS. (1995) (54)
Asymmetric Total Synthesis of the Gastroprotective Microbial Agent AI-77-B. (2003) (53)
Design, Synthesis and X-ray Structure of Protein−Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors (2006) (53)
A stereoselective synthesis of (+)-herboxidiene/GEX1A. (2011) (52)
Joint X-ray/neutron crystallographic study of HIV-1 protease with clinical inhibitor amprenavir: insights for drug design. (2013) (52)
A stereoselective synthesis of (-)-tetrahydrolipstatin. (1999) (51)
Total synthesis and structural revision of (+)-amphidinolide W. (2004) (51)
The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry (2018) (51)
Enantioselective total synthesis of peloruside A: a potent microtubule stabilizer. (2008) (51)
Enantioselective synthesis of (-)-platensimycin oxatetracyclic core by using an intramolecular Diels-Alder reaction. (2007) (50)
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity. (2002) (50)
Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors. (2005) (49)
cis-1-Aminoindan-2-ol in Asymmetric Syntheses. (1998) (49)
Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs. (2013) (48)
Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester-Derived Titanium Enolate Syn and Anti-Aldol Reactions. (1998) (48)
Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecules. (2001) (48)
Development of protease inhibitors and the fight with drug-resistant HIV-1 variants. (2008) (48)
A Non‐Antibacterial Oxazolidinone Derivative that Inhibits Epithelial Cell Sheet Migration (2002) (47)
Alpha-fluorovinyl Weinreb amides and alpha-fluoroenones from a common fluorinated building block. (2009) (47)
Enantioselective synthesis of (+)-cryptophycin 52 (LY355703), a potent antimitotic antitumor agent. (2003) (45)
Total synthesis and revision of C6 stereochemistry of (+)-amphidinolide W. (2006) (45)
Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity. (2010) (45)
(−)-Doliculide, a New Macrocyclic Depsipeptide Enhancer of Actin Assembly* (2002) (45)
STEREOSELECTIVE REDUCTION OF α-HYDROXY OXIME ETHERS: A CONVENIENT ROUTE TO CIS-1,2-AMINO ALCOHOLS. (1991) (45)
Enantioselective total synthesis of macrolide antitumor agent (-)-lasonolide A. (2007) (44)
Assignment of absolute stereochemistry and total synthesis of (-)-spongidepsin. (2004) (44)
Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease. (2008) (44)
An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors. (1991) (44)
Probing Multidrug‐Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV‐1 Protease Inhibitors (2010) (43)
Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor. (2012) (42)
Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies. (2013) (42)
Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance. (2009) (41)
GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection (2020) (41)
Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease. (2009) (41)
Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. (2007) (41)
Critical differences in HIV‐1 and HIV‐2 protease specificity for clinical inhibitors (2012) (41)
Mn(III)-PROMOTED ANNULATION OF ENOL ETHERS AND ESTERS TO FUSED OR SPIRO 2-CYCLOPENTENONES. (1987) (41)
Asymmetric synthesis of anti-aldol segments via a nonaldol route: synthetic applications to statines and (-)-tetrahydrolipstatin. (2009) (40)
Prediction of Potency of Protease Inhibitors Using Free Energy Simulations with Polarizable Quantum Mechanics-Based Ligand Charges and a Hybrid Water Model (2009) (40)
ASYMMETRIC HETERO DIELS-ALDER REACTIONS OF DANISHEFSKY'S DIENE AND GLYOXYLATE ESTERS CATALYZED BY CHIRAL BISOXAZOLINE DERIVED CATALYSTS. (1996) (40)
GRL-02031, a Novel Nonpeptidic Protease Inhibitor (PI) Containing a Stereochemically Defined Fused Cyclopentanyltetrahydrofuran Potent against Multi-PI-Resistant Human Immunodeficiency Virus Type 1 In Vitro (2008) (40)
Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy (2006) (39)
Preparation and utility of trihaloethyl imidates: useful reagents for the synthesis of amidines. (2010) (38)
Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies. (2008) (38)
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. (2002) (38)
Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome. (2013) (38)
The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses. (2018) (37)
Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran. (2013) (37)
Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance (2018) (36)
Cycloaddition approach to benzo-annulated indane-based α-amino acid derivatives (2004) (36)
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies (2021) (35)
Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1 (2011) (35)
The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors. (2013) (35)
Tetrahydrofuran, tetrahydropyran, triazoles and related heterocyclic derivatives as HIV protease inhibitors. (2011) (35)
3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease. (1993) (34)
Total Synthesis of (+)-Sinefungin. (1996) (34)
A stereoselective synthesis of (+)-boronolide. (2000) (34)
Cu(II)-catalyzed olefin migration and Prins cyclization: highly diastereoselective synthesis of substituted tetrahydropyrans. (2011) (34)
The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [3H]Peloruside A (2010) (34)
Enantioselective total synthesis of (+)-lithospermic acid. (2012) (34)
Enantioselective total synthesis of +-jasplakinolide. (2007) (33)
Fluorinated 1-phenyl-1H-tetrazol-5-yl sulfone derivatives as general reagents for fluoroalkylidene synthesis. (2009) (33)
Achmatowicz Reaction and its Application in the Syntheses of Bioactive Molecules. (2016) (33)
HIGHLY STEREOSELECTIVE REDUCTION OF α-KETO ESTERS: UTILITY OF CIS-1-ARYLSULFONAMIDO-2-INDANOLS AS CHIRAL AUXILIARIES. (1995) (33)
Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. (2012) (33)
An asymmetric total synthesis of brevisamide. (2009) (32)
Conformations of laulimalide in DMSO-d6. (2005) (32)
Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic. (1993) (32)
Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy. (2012) (32)
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency (2017) (32)
Prediction of Potency of Protease Inhibitors Using Free Energy Simulations with Polarizable Quantum Mechanics‐Based Ligand Charges and a Hybrid Water Model. (2010) (32)
Cu-catalyzed N-arylation of oxazolidinones: an efficient synthesis of the kappa-opioid receptor Agonist CJ-15161. (2006) (31)
Selective growth promotion and growth inhibition of Gram-negative and Gram-positive bacteria by synthetic siderophore-β-lactam conjugates (2004) (31)
An enantioselective synthesis of the C2-C16 segment of antitumor macrolide laulimalide1. (2000) (31)
Design of HIV-1 protease inhibitors with C3-substituted hexahydrocyclopentafuranyl urethanes as P2-ligands: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. (2011) (31)
Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality. (2007) (31)
Di(2-Pyridyl) Carbonate Promoted Alkoxycarbonylation of Amines: A Convenient Synthesis of Functionalized Carbamates. (1992) (31)
Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants (2018) (31)
Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease. (2013) (30)
A symmetry-based concise formal synthesis of platencin, a novel lead against "superbugs". (2009) (30)
Total Synthesis of (+)-Polyoxin J. (1999) (30)
Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives (2014) (30)
Fluoro-Julia olefination as a mild, high-yielding route to alpha-fluoro acrylonitriles. (2008) (30)
A Convergent, Enantioselective Total Synthesis of Streptogramin Antibiotic (-)-Madumycin II. (1997) (30)
ESTER DERIVED TITANIUM ENOLATE ALDOL REACTION: HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF SYN- AND ANTI-ALDOLS. (1997) (29)
Chelation-controlled reduction: stereoselective formation of syn-1,3-diols and synthesis of compactin and mevinolin lactone. (2002) (29)
Diels-Alder approach to tetralin-based constrained α-amino acid derivatives (2000) (29)
P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety (2013) (29)
CHEMOSELECTIVE CATALYTIC HYDROGENATION OF ALKENES BY LINDLAR CATALYST. (1998) (28)
Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir. (2008) (28)
Methods for Pyranoannulation: An Approach to a New Class of Polyethers. (1985) (28)
Two-Step Synthesis of Furans by Mn(III)-Promoted Annulation of Enol Ethers. (1987) (28)
Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants (2011) (27)
Aspartic Acid Proteases as Therapeutic Targets: GHOSH:PROTEASES DRUG TARG (2010) (27)
Design of the anti-HIV protease inhibitor darunavir (2013) (27)
A Diels-alder approach for the synthesis of highly functionalized benzo-annulated indane-based α-amino acid derivatives via a sultine intermediate (2004) (27)
Design, synthesis, and X-ray structure of substituted bis-tetrahydrofuran (bis-THF)-derived potent HIV-1 protease inhibitors (2011) (26)
CYCLIC SULFONE-3-CARBOXAMIDES AS NOVEL P2-LIGANDS FOR Ro 31-8959 BASED HIV-1 PROTEASE INHIBITORS. (1995) (26)
Bis(oxazoline) derived cationic aqua complexes: highly effective catalysts for enantioselective Diels-Alder reactions. (1998) (26)
Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease. (2002) (26)
Anharmonic modeling of the conformation-specific IR spectra of ethyl, n-propyl, and n-butylbenzene. (2016) (26)
STEREOCONTROLLED SYNTHESIS OF HIV-l PROTEASE INHIBITORS WITH C2-AXIS OF SYMMETRY. (1991) (26)
Highly diastereoselective anti-aldol reactions utilizing the titanium enolate of cis-2-arylsulfonamido-1- acenaphthenyl propionate. (2003) (26)
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. (2018) (26)
The Isoxazoline Route to α-Methylene Lactones. (1983) (25)
Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV-1 Inhibitors (2015) (25)
Asymmetric Aldol Route to Hydroxyethylamine Isostere: Stereoselective Synthesis of the Core Unit of Saquinavir. (1997) (25)
TiCl4 Promoted Three Component Coupling Reaction : A New Method for the Synthesis of Functionalized Tetrahydrofurans and Tetrahydropyrans. (1999) (25)
Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine. (2010) (25)
An enantioselective synthesis of the C1-C9 segment of antitumor macrolide peloruside A. (2003) (24)
Lasonolide A, a potent and reversible inducer of chromosome condensation (2012) (24)
The Gender Gap in Literacy and Education among the Scheduled Tribes in Jharkhand and West Bengal (2007) (24)
Highly Enantioselective Aldol Reaction: Development of a New Chiral Auxiliary from cis-1-Amino-2-hydroxyindan. (1993) (24)
Stereoselective chloroacetate aldol reactions: syntheses of acetate aldol equivalents and darzens glycidic esters. (2004) (24)
A Convergent, Enantioselective Total Synthesis of Hapalosin: A Drug with Multidrug-Resistance Reversing Activity. (1996) (24)
Asymmetric hetero Diels-Alder route to quaternary carbon centers: synthesis of (-)-malyngolide. (2001) (24)
Synthetic studies of microtubule stabilizing agent peloruside A: an asymmetric synthesis of C10-C24 segment. (2003) (24)
Synthesis of enantiomerically pure 5'-aza-noraristeromycin analogs (1995) (24)
GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro (2013) (24)
Synthesis of novel citrate-based siderophores and siderophore-.beta.-lactam conjugates. Iron transport-mediated drug delivery systems (1993) (23)
Enantioselective total synthesis of macrolide (+)-neopeltolide. (2013) (23)
Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies (2014) (22)
On hydromagnetic rotating flow of a dusty fluid near a pulsating plate (2008) (22)
GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1 In Vitro and Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration (2013) (22)
L-selectride-mediated highly diastereoselective asymmetric reductive aldol reaction: access to an important subunit for bioactive molecules. (2008) (22)
Prospects of β‐Secretase Inhibitors for the Treatment of Alzheimer’s Disease (2015) (22)
Enantioselective Synthesis of Spiro[cyclohexane-1,3'-indolin]-2'-ones Containing Multiple Stereocenters via Organocatalytic Michael/Aldol Cascade Reactions. (2013) (22)
Stereoselective synthesis of the C(1)-C(12) segment of iriomoteolide 1a: a very potent macrolide antitumor agent. (2009) (22)
Stereocontrolled synthesis of (±)-debromoaplysin, (±)-aplysin, (±)-debromoaplysinol, (±)-aplysinol, and (±)-isoaplysin (1990) (22)
Rapid, high-yield synthesis of the marine sesquiterpenes debromoaplysin and aplysin via the acid-catalyzed rearrangement of a cyclobutachromanol (1992) (21)
Synthesis of Symmetrical Sulfones from Rongalite: Expansion to Cyclic Sulfones by Ring‐Closing Metathesis (2005) (21)
Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane That Are Potent against Multi-PI-Resistant HIV-1 Variants In Vitro (2010) (21)
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors. (2012) (21)
Synthesis of Symmetrical and Unsymmetrical 9,10-Diarylanthracene Derivatives via Bis-Suzuki-Miyaura Cross-Coupling Reaction (2004) (21)
Benzimidazole-Based FabI Inhibitors: A Promising Novel Scaffold for Anti-staphylococcal Drug Development. (2017) (21)
Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition. (2018) (20)
Synthetic studies of antitumor macrolide laulimalide: a stereoselective synthesis of the C17-C28 segment. (2000) (20)
The Diels-Alder approach for the synthesis of tetralin-based α-amino acid derivatives and their modification by the Suzuki-Miyaura cross-coupling reaction (2004) (20)
Defining Viral Defective Ribosomal Products: Standard and Alternative Translation Initiation Events Generate a Common Peptide from Influenza A Virus M2 and M1 mRNAs (2016) (20)
A Stereoselective Anti-Aldol Route to (3R,3aS,6aR)-Hexahydrofuro[2,3-b] furan-3-ol: A Key Ligand for a New Generation of HIV Protease Inhibitors. (2006) (20)
Titanium(III)-mediated synthesis of a 1,2,3-tricarbonyl moiety from an .alpha.-oximido-.beta.-keto ester: application to the synthesis of the carbacephem nucleus (1992) (20)
Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies. (2018) (20)
Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications (2013) (20)
Phosphine-mediated [4 + 2] annulation of bis(enones): a Lewis base catalyzed "mock Diels-Alder" reaction. (2004) (20)
Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity (2009) (20)
Design of gem‐Difluoro‐bis‐Tetrahydrofuran as P2 Ligand for HIV‐1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X‐ray Studies, and Biological Evaluation (2015) (20)
Asymmetric dihydroxylation route to a dipeptide isostere of a protease inhibitor: enantioselective synthesis of the core unit of ritonavir. (1999) (19)
Direct synthesis of 8-fluoro purine nucleosides via metalation-fluorination. (2007) (19)
Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies. (2015) (18)
X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design (2015) (18)
Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease (2018) (18)
Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands. (2015) (18)
Asymmetric alkylations and aldol reactions: (1S,2R)-2-aminocyclopentan-1-ol derived new chiral auxiliary. (1997) (18)
TiCl4-Promoted Multicomponent Reaction: A New Entry to Functionalized α-Amino Acids (2005) (18)
Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors (2021) (17)
Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors. (2012) (17)
Enantioselective Synthesis of Spliceostatin E and Evaluation of Biological Activity (2014) (17)
Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). (2015) (17)
Expedient synthesis of α-substituted fluoroethenes. (2012) (17)
Total synthesis of potent antitumor agent (-)-lasonolide A: a cycloaddition-based strategy. (2008) (17)
Enantioselective syntheses of the proposed structures of cytotoxic macrolides iriomoteolide-1a and -1b. (2010) (17)
A macrolactonization-based strategy to obtain microtuble-stabilizing agent (-)-laulimalide. (2001) (17)
Total Synthesis of GEX1Q1, Assignment of C-5 Stereoconfiguration and Evaluation of Spliceosome Inhibitory Activity (2014) (17)
Improving People's Lives: Lessons in empowerment from Asia (2004) (17)
S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase (2013) (17)
Differentiating Isomeric Deprotonated Glucuronide Drug Metabolites via Ion/Molecule Reactions in Tandem Mass Spectrometry. (2018) (16)
A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV (2014) (16)
Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. (2015) (16)
Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I. (2019) (16)
Enantioselective Synthesis of Both Epimers at C-21 in the Proposed Structure of Cytotoxic Macrolide Callyspongiolide. (2016) (16)
FeCl3-Catalyzed Tandem Prins and Friedel-Crafts Cyclization: A Highly Diastereoselective Route to Polycyclic Ring Structures. (2014) (16)
Bifunctional cinchona alkaloid-squaramide-catalyzed highly enantioselective aza-Michael addition of indolines to α,β-unsaturated ketones. (2013) (15)
Chelation-controlled ester-derived titanium enolate aldol reaction: diastereoselective syn-aldols with mono- and bidentate aldehydes. (2002) (15)
INTRAMOLECULAR AND INTERMOLECULAR HYDROXYL REACTIVITY DIFFERENCES IN GINKGOLIDES A, B AND C AND THEIR CHEMICAL APPLICATIONS. (1992) (15)
Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands. (2014) (15)
Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines. (2006) (15)
ASYMMETRIC DIELS-ALDER REACTION : CIS-1-ARYLSULFONAMIDO-2-INDANOLS AS HIGHLY EFFECTIVE CHIRAL AUXILIARIES. (1996) (15)
Synthesis of 9,10-Diarylanthracene Derivatives via bis Suzuki-Miyaura Cross-coupling Reaction (2002) (15)
Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope against Drug‐Resistant HIV (2011) (14)
Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned? (2011) (14)
Photolysis of α-diazocyclopentanones. Ring contraction to functionalised cyclobutanes and synthesis of junionone, grandisol and planococcyl acetate (1990) (14)
Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies. (2008) (14)
Second‐Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS (2011) (14)
Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring. (2012) (14)
Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. (2006) (14)
The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease (2016) (14)
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex. (2017) (14)
Convenient synthesis of novel macrocyclic urethanes: alkoxycarbonylation of amines and ring-closing metathesis strategy. (1998) (14)
Stereoselective construction of quaternary carbon centers by three component coupling reactions. (2000) (13)
5,5-Dimethyl-1,4,2-dioxazoles as versatile aprotic hydroxamic acid protecting groups. (2002) (13)
Stereoselective synthesis of both tetrahydropyran rings of the antitumor macrolide, (-)-lasonolide A. (2012) (13)
TiC14 promoted three component coupling reaction: an efficient method for the substituted tetrahydropyrilidene acetates. (1999) (13)
Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate (2006) (13)
Bis‐Tetrahydrofuran: A Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors that Combat Drug Resistance. (2006) (13)
Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation (2015) (13)
Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity. (2018) (13)
GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro (2017) (13)
HIV Protease Inhibitor (1992) (13)
A Novel Tricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor, GRL-0739, Effectively Inhibits the Replication of Multidrug-Resistant HIV-1 Variants and Has a Desirable Central Nervous System Penetration Property In Vitro (2015) (12)
Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands. (2010) (12)
A convergent synthesis of the proposed structure of antitumor depsipeptide stereocalpin A. (2009) (12)
Synthesis of the kappa-agonist CJ-15,161 via a palladium-catalyzed cross-coupling reaction. (2002) (12)
HIV-Associated Neurocognitive Disorder (HAND) and the Prospect of Brain-Penetrating Protease Inhibitors for Antiretroviral Treatment. (2017) (12)
A Facile and Enantiospecific Synthesis of 2(S)- and 2(R)-[1'(S)-Azido-2-phenylethyl]oxirane. (1992) (12)
Potent Memapsin 2 (β-Secretase) Inhibitors: Design, Synthesis, Protein-Ligand X-Ray Structure, and in vivo Evaluation. (2008) (12)
Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies (2019) (12)
Stereoselective Synthesis of Protected Thymine Polyoxin C via [2,3]-Wittig-Still Rearrangement of Ribose-Derived Allylic Stannyl Ethers. (1998) (12)
Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies. (2015) (12)
MULTICOMPONENT REACTIONS: SYNTHESIS OF SPIROCYCLIC TETRAHYDROPYRAN DERIVATIVES BY PRINS CYCLIZATION. (2002) (12)
Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy. (2002) (12)
A Convenient Enzymatic Route to Optically Active l-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses. (1997) (12)
Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies. (2020) (12)
C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir (2015) (12)
Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation. (2016) (12)
The Development of Titanium Enolate‐based Aldol Reactions (2008) (12)
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 and Covid‐19 (2022) (11)
Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction. (2010) (11)
Enantioselective Total Synthesis of (+)-Amphirionin-4. (2016) (11)
Stereoselective Synthesis of 5-O-Carbamoylpolyoxamic Acid by [2,3]-Wittig-Still Rearrangement. (1999) (11)
Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors. (2008) (11)
An Efficient Synthesis of Functionalized Urethanes from Azides. (1992) (11)
A stereoselective synthesis of (-)-viridiofungin A utilizing a TiCl(4)-promoted asymmetric multicomponent reaction. (2012) (11)
Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene. (2016) (11)
A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413 (2016) (11)
TiCl4-promoted tandem carbonyl or imine addition and Friedel-Crafts cyclization: synthesis of benzo-fused oxabicyclooctanes and nonanes. (2012) (11)
Enantioselective Syntheses of (-)-Alloyohimbane and (-)-Yohimbane by an Efficient Enzymatic Desymmetrization Process. (2016) (11)
Stereoselective Synthesis of Dihydroisocoumarin Moiety of Microbial Agent AI-77-B: a Diels-Alder Based Strategy. (1998) (11)
Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester. (2018) (11)
Chiral Auxiliary Mediated Conjugate Reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors. (1995) (11)
An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones. (2014) (10)
Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group (2012) (10)
Synthesis of amide derivatives for electron deficient amines and functionalized carboxylic acids using EDC and DMAP and a catalytic amount of HOBt as the coupling reagents. (2021) (10)
Synthetic Studies towards A trans-3,4-Diamine Derivative of Piperidine Mimicking Buspirone (1994) (10)
Immunodeficiency Virus In Vitro against Multi-PI-Resistant Human UIC-94017 ( TMC 114 ) with Potent Activity Nonpeptidic Protease Inhibitor ( PI )-Tetrahydrofuranylurethane-Containing bis Novel (2003) (10)
Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes (2016) (10)
A Tandem Olefin Migration and Prins Cyclization Using Cu(OTf)(2)-Bisphosphine Complexes: An Improved Synthesis of Functionalized Tetrahydropyrans. (2012) (10)
An Enantioselective Synthesis of a MEM-Protected Aetheramide A Derivative. (2014) (10)
Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands. (2017) (10)
Ester derived titanium enolate aldol reaction: chelation controlled diastereoselective synthesis of syn-aldols. (2001) (10)
Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). (2005) (10)
Characterization of a Drosophila Ortholog of the Cdc7 Kinase (2014) (10)
Indian industrialization : structure and policy issues (1992) (9)
Asymmetric multi-component reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids. (2008) (9)
The FDA Approved HIV-1 Protease Inhibitors for Treatment of HIV/AIDS (2010) (9)
Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20. (2015) (9)
1,2,3-TRIAZOLES FROM (Z)-BETA -(FORMYLOXY)VINYL AZIDES AND TRIETHYL PHOSPHITE (1991) (9)
Stereocontrolled synthesis of (±)-debromoaplysin and (±)-aplysin (1988) (9)
Enantioselective Synthesis of Cyclopentyltetrahydrofuran (Cp-THF), an Important High-Affinity P2-Ligand for HIV-1 Protease Inhibitors. (2008) (9)
Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20. (2019) (9)
Study of memapsin 2 (β-secretase) and strategy of inhibitor design (2007) (9)
Changing livelihood pattern of slum dwellers in Delhi: From a squatter settlement to a resettlement colony (2008) (8)
Enantioselective total synthesis and structural assignment of callyspongiolide. (2016) (8)
Stereoselective Synthesis of Substituted Oxocene Cores by Lewis Acid Promoted Cyclization. (2016) (8)
Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A. (2004) (8)
Total Synthesis of (-)-Laulimalide. (2000) (8)
Determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors through the support of electronic circular dichroism and MM-GBSA techniques. (2018) (8)
Design of substituted bis-Tetrahydrofuran (bis-THF)-derived Potent HIV-1 Protease Inhibitors, Protein-ligand X-ray Structure, and Convenient Syntheses of bis-THF and Substituted bis-THF Ligands. (2011) (8)
Diastereoselective Synthesis of Substituted Tetrahydropyrans by Copper(II)-Bisphosphine-Catalyzed Olefin Migration and Prins Cyclization. (2012) (8)
Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs. (2010) (8)
Political Economy of Structural Readjustment (1991) (8)
Enantioselective Total Syntheses of (+)-Fendleridine and (+)-Acetylaspidoalbidine. (2019) (8)
Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications (2019) (8)
Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands. (2015) (8)
Copper-Catalyzed Stille Cross-Coupling Reaction and Application in the Synthesis of the Spliceostatin Core Structure. (2020) (7)
Enhancing Protein Backbone Binding — A Fruitful Concept for Combating Drug-Resistant HIV. (2012) (7)
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity (2020) (7)
Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors (2014) (7)
Julia Olefination as a General Route to Phenyl (α-Fluoro)vinyl Sulfones (2008) (7)
Synthesis of Functionalized 4-Methylenetetrahydropyrans by Oxidative Activation of Cinnamyl or Benzyl Ethers. (2012) (7)
Darunavir (Prezista): A HIV‐1 Protease Inhibitor for Treatment of Multidrug‐Resistant HIV (2010) (7)
Synthesis of Bioactive Natural Products by Asymmetric syn- and anti-Aldol Reactions. (2009) (7)
Critical Analysis on Role of Women in Sericulture Industry (2017) (7)
A fission yeast cell-based system for multidrug resistant HIV-1 proteases (2017) (7)
On hydromagnetic rotating flow of an Oldroyd-B fluid near an oscillating plate (2009) (7)
Development of an efficient enzyme production and structure-based discovery platform for BACE1 inhibitors. (2019) (7)
Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants (2019) (7)
Butanol-Based Organosolv Lignin and Reactive Modification of Poly(ethylene-glycidyl methacrylate) (2019) (6)
Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance (2008) (6)
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors. (2021) (6)
Cover Feature: Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies (ChemMedChem 5/2019) (2019) (6)
Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans. (2017) (6)
An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A. (2003) (6)
Study of memapsin 2 (beta-secretase) and strategy of inhibitor design. (2003) (6)
Antinomies of Society (2000) (6)
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands. (2017) (6)
Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers (2017) (6)
Eighth Plan Challenges and Possibilities (1991) (6)
Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities. (2020) (6)
A Note on Hydromagnetic Flow of an Oldroyd-B Fluid near an Infinite Plate Induced by Half Rectified Sine Pulses (2014) (6)
Identification of herboxidiene features that mediate conformation-dependent SF3B1 interactions to inhibit splicing (2020) (6)
A convergent synthesis of carbocyclic sinefungin and its C5 epimer. (2014) (6)
Cooperative movement and rural development in India (2007) (5)
An enantioselective enzymatic desymmetrization route to hexahydro-4H-furopyranol, a high-affinity ligand for HIV-1 protease inhibitors. (2017) (5)
Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine–CCR5 interactions (2010) (5)
Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir (2017) (5)
Planning in India: The Challenge for the Nineties (1992) (5)
Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization. (2015) (5)
Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies (2019) (5)
Synthetic studies of nucleoside antibiotics: a formal synthesis of (+)-sinefungin. (2000) (5)
Efficient synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol via a Dakin–West reaction followed by enantioselective reduction (2008) (5)
Highly Stereoselective Asymmetric Aldol Routes to tert-Butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building Blocks for Novel Protease Inhibitors. (2017) (5)
Synthesis of (-)-Tetrahydrolipstatin (2010) (5)
GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants (2018) (5)
Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation. (2019) (5)
The Discovery of β‐Secretase and Development toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration (2011) (5)
The Smile of the Cheshire Cat (1994) (4)
Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance (2019) (4)
ALTERED ULTRASTRUCTURE OF RINDERPEST VIRUS AND ITS NUCLEOCAPSIDS INDUCED BY 5-FLUOROURACIL (1994) (4)
Fluorescent Probes for Monitoring Serine Ubiquitination. (2020) (4)
The Chiron Approach to (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol, a Key Subunit of HIV-1 Protease Inhibitor Drug, Darunavir. (2020) (4)
An enantioselective synthesis of the C3-C21 segment of the macrolide immunosuppressive agent FR252921. (2016) (4)
TOTAL SYNTHESIS OF GINKGOLIDE A. (2022) (4)
Role of magnesium sulfate in prolonging the analgesic effect of spinal bupivacaine for cesarean section in severe preeclamptics (2015) (4)
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors (2021) (4)
Structure Based Design: Novel Spirocyclic Ethers as Nonpeptidal P2‐Ligands for HIV Protease Inhibitors. (1998) (4)
Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s (2019) (4)
Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans. (2020) (4)
Prices and economic fluctuations in India, 1861-1947 (1979) (4)
Synthesis of Symmetrical and Unsymmetrical 9,10-Diarylanthracene Derivatives via Bis-Suzuki—Miyaura Cross-Coupling Reaction. (2004) (3)
Convenient Synthesis of Bicyclic Lactones Related to the Trichothecenes (1988) (3)
Neuraminidase Inhibitors for the Treatment of Influenza: Design and Discovery of Zanamivir and Oseltamivir (2015) (3)
A Photochemical Route to Optically Active Hexahydro-4H-furopyranol, a High-Affinity P2 Ligand for HIV-1 Protease Inhibitors. (2019) (3)
Stereoselective Synthesis of the C11-N26 Fragment of Griseoviridin. (2002) (3)
Chapter 9 First total synthesis of (+)-Amphidinolide T1 (2004) (3)
Social dimensions of economic development: An overview (2000) (3)
Diels—Alder Approach to Tetralin-Based Constrained α-Amino Acid Derivatives. (2000) (3)
Enantioselective Synthesis of (‐)‐Platensimycin Oxatetracyclic Core by Using an Intramolecular Diels—Alder Reaction. (2008) (3)
Cyclical Trends in Indian Agriculture 1861-1913 (1967) (3)
Intramolecular Acylation During Acid Chloride Formation of Some o-Styryl Phenoxyacetic Acids (1991) (3)
In vivo efficacy of BACE-1 inhibitor CTS21166 (ASP1702) in rat CNS compartments (2009) (3)
Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PRS17. (2021) (3)
On Hydromagnetic Flow of an Oldroyd-B Fluid Between Two Oscillating Plates (2016) (3)
Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance. (2022) (3)
Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties. (2019) (3)
Memapsin 2, a drug target for Alzheimer's disease. (2003) (3)
Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands. (2018) (3)
Cover Picture: Probing Multidrug-Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors (ChemMedChem 11/2010) (2010) (3)
Design of Serine Protease Inhibitors (2015) (3)
Development of HIV-1 protease inhibitors, antiretroviral resistance, and current challenges of HIV/AIDS management (2011) (3)
Price Movements and Fluctuations in Economic Activity (1860-1947): A Review of McAlpin's Contribution to CEHI (1984) (3)
Total Synthesis of (+)-Sinefungin. (1997) (2)
Harnessing Nature′s Insight: Design of Aspartyl Protease Inhibitors from Treatment of Drug-Resistant HIV to Alzheimer′s Disease (2009) (2)
Adjustment Programmes and Interest Rate Policy (1994) (2)
A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance. (2019) (2)
Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors. (2018) (2)
Industrial Policy and the Economy (1985) (2)
The World Bank and the Attack on World Poverty (1987) (2)
Restoration of human dignity : impact of development programmes on scavengers (1994) (2)
Fluoro-Julia Olefination as a Mild, High-Yielding Route to α-Fluoro Acrylonitriles. (2009) (2)
A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors. (2021) (2)
Female literacy and social development (2003) (2)
Total Synthesis and Revision of C6 Stereochemistry of (+)‐Amphidinolide W (I). (2006) (2)
The moments of Bengal partition : selections from the Amrita Bazar Patrika, 1947-48 (2010) (2)
Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecules (2001) (2)
Stereocontrolled Synthesis of HIV-1 Protease Inhibitors with C2-Axis of Symmetry. (1992) (2)
P4-374 In vivo inhibition of brain Aβ level by memapsin 2 (β-secretase) inhibitors (2004) (2)
Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands. (2006) (2)
Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro (2022) (2)
Enantioselective Total Synthesis of (+)-EBC-23, a Potent Anticancer Agent from the Australian Rainforest. (2021) (2)
Enantioselective total synthesis of decytospolide A and decytospolide B using an Achmatowicz reaction. (2018) (2)
Development of an efficient structure‐based drug discovery platform for BACE1 Inhibitors for the treatment of Alzheimer's Disease (2016) (2)
A Convergent Synthesis of (+)‐Cryptophycin B, a Potent Antitumor Macrolide from Nostoc sp. Cyanobacteria. (2000) (2)
The Development of Cyclic Sulfolanes as Novel and High‐Affinity P2 Ligands for HIV‐1 Protease Inhibitors. (1994) (2)
A new and simple synthetic approach to functionalized sulphone derivatives by the Suzuki-Miyaura cross-coupling reaction (2006) (2)
β‐Secretase Inhibitors for the Treatment of Alzheimer's Disease: Preclinical and Clinical Inhibitors (2015) (2)
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand. (2018) (2)
Cu-Catalyzed N-Arylation of Oxazolidinones: An Efficient Synthesis of the ϰ-Opioid Receptor Agonist CJ-15161 (I). (2006) (2)
Selected Metal‐Mediated Cross‐Coupling Reactions (2011) (2)
Federalism, Democracy and Decentralisation (1992) (2)
Carbonic Anhydrase Inhibitors for the Treatment of Glaucoma: Design and Discovery of Dorzolamide (2015) (2)
Highly Diastereoselective Intramolecular Asymmetric Oxidopyrylium-olefin [5 + 2] Cycloaddition and Synthesis of 8-Oxabicyclo[3.2.1]oct-3-enone Containing Ring Systems. (2021) (1)
Enantioselective Total Synthesis of (+)‐Jasplakinolide. (2007) (1)
The Diels—Alder Approach for the Synthesis of Tetralin-Based α-Amino Acid Derivatives and Their Modification by the Suzuki—Miyaura Cross-Coupling Reaction. (2004) (1)
Total Synthesis of Potent Antitumor Agent (‐)‐Lasonolide A: A Cycloaddition‐Based Strategy. (2009) (1)
The Diels–Alder Approach for the Synthesis of Tetralin-Based a-Amino Acid Derivatives and their Modification by the Suzuki–Miyaura Cross-Coupling Reaction Diels–Alder Approach for the Synthesis of Tetralin-Based a-Amino Acid Derivatives (2004) (1)
Economics of Amartya Sen (2000) (1)
NS3/4A Serine Protease Inhibitors for the Treatment of HCV: Design and Discovery of Boceprevir and Telaprevir (2015) (1)
Education and Environment-Contribution of the Paper Industry (1987) (1)
Capturing the Essence of Organic Synthesis: From Bioactive Natural Products to Designed Molecules in Today′s Medicine (2011) (1)
Supply Side Economics-Is India Ready for the Recipe (1988) (1)
cis‐1‐Aminoindan‐2‐ol in Asymmetric Syntheses (1998) (1)
A fission yeast cell-based system for multidrug resistant HIV-1 proteases (2017) (1)
A Diels—Alder Approach for the Synthesis of Highly Functionalized Benzo-annulated Indan-Based α-Amino Acid Derivatives via a Sultine Intermediate. (2004) (1)
Indigenous Education at Crossroads: James Baycree and the Tribal People of Orissa; (2008) (1)
Novel Cyclourethane‐Derived HIV Protease Inhibitors: A Ring‐Closing Olefin Metathesis Based Strategy. (2002) (1)
HIV‐1 Protease Inhibitors for the Treatment of HIV Infection and AIDS: Design of Saquinavir, Indinavir, and Darunavir (2015) (1)
A structure-guided taxonomicbased approach to the design of broad-spectrum coronavirus protease inhibitors (2021) (1)
Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase). (2004) (1)
A Diachronic Study of the Political Economy of Ranikhera Village in Delhi (2012) (1)
The Budget, Inflation and All That (1987) (1)
Conserved hydrogen-bonding network of P2 bis-tetrahydrofuran (2014) (1)
Economy and the Budget (2016) (1)
Globalization and WTO (1998) (1)
Convergent synthesis of (+)-carambolaflavone A, an antidiabetic agent using a bismuth triflate-catalyzed C-aryl glycosylation. (2022) (1)
Money Stock, Velocity and Monetary Savings (1988) (1)
Development of Direct Thrombin Inhibitor, Dabigatran Etexilate, as an Anticoagulant Drug (2015) (1)
X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors (2006) (1)
Design and synthesis of herboxidiene derivatives that potently inhibit in vitro splicing. (2021) (1)
3′‐Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease. (1993) (1)
Bibliotheca Austroasiatica : a classified and annotated bibliography of the austroasiatic people and languages (1988) (1)
Design, Synthesis, Protein-ligand X-ray Structures and Biological Evaluation of a Series of Novel Macrocyclic HIV-1 Protease Inhibitors to Combat Drug-resistance (2010) (1)
GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro (2017) (0)
Chelation‐Controlled Reduction: Stereoselective Formation of syn‐1,3‐Diols and Synthesis of Compactin and Mevinolin Lactone. (2003) (0)
Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands (2022) (0)
Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure‐Based Design, Synthesis, and Biological Evaluation. (1996) (0)
Customer Lifetime Value Prediction: A Study on Multiple Brands Purchase of Consumer Packaged Goods (2020) (0)
HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics. (2022) (0)
Angiotensin‐Converting Enzyme Inhibitors for the Treatment of Hypertension: Design and Discovery of Captopril (2015) (0)
Design of Inhibitors of Aspartic Acid Proteases (2015) (0)
Asymmetric 1,2-Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective synthesis of α-Hydroxy Amides. (2022) (0)
X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in apo state (2020) (0)
X-ray crystal structure of darunavir-resistant HIV-1 protease (P51) in complex with GRL-003 (2020) (0)
Decarboxylation of α-Cyanoalkylidene Esters and Acids. Synthesis of Cyclohexyl Constituents of the Pheromone of the Boll Weevil. (1986) (0)
Fused 6,5 bicyclic ring system p2 ligands, and methods for treating hiv (2011) (0)
Erratum: Diastereofacial selection in nitrile oxide cycloaddition reactions. The anti-directing effect of an allylic oxygen and some new results on the ring metalation of isoxazolines. A synthesis of (±)-blastmycinone (Journal of Organic Chemistry (1984) 49, 25, (2771)) (1984) (0)
X-ray crystal structure of darunavir-resistant HIV-1 protease (P51) in complex with GRL-001 (2020) (0)
Synthesis of Symmetrical Sulfones from Rongalite: Expansion to Cyclic Sulfones by Ring-Closing Metathesis. (2005) (0)
Peptide from Influenza A Virus M 2 and M 1 Initiation Events Generate a Common Standard and Alternative Translation Defining Viral Defective Ribosomal Products : (2016) (0)
Berlare (BE): Dominique Louis Nestor FOREIGN PATENT DOCUMENTS (2017) (0)
The Design , Development , and Evaluation of BACE 1 Inhibitors for the Treatment of Alzheimer ’ s Disease (2017) (0)
Tribal Communities and Social Change (2006) (0)
Novel protease inhibitors markedly adapting to the structural plasticity of HIV-1 protease exert extreme potency with high genetic barrier (2018) (0)
Co-crystal of BACE1 with compound 0211 (2016) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-085 (2016) (0)
National Population Policy-Progression towards a Fascist State (1994) (0)
Procede de preparation de (3r, 3as, 6ar) -3- hydroxyhexahydrofuro [2, 3-b] furane et de composes apparentes (2003) (0)
Sociology of poverty: Some conceptual issues (2005) (0)
Enantioselective Syntheses of FR901464 (Ib) and Spliceostatin A (Ia): Potent Inhibitors of Spliceosome. (2014) (0)
Crystal structure analysis of HIV-1 protease mutant V82A with a inhibitor saquinavir (2007) (0)
High Resolution HIV-2 Protease Structure in Complex with Antiviral Inhibitor GRL-06579A (2008) (0)
A Glimpse at a Public Sector Enterprise (1992) (0)
Cycloaddition Approach to Benzo‐Annulated Indan‐Based α‐Amino Acid Derivatives. (2005) (0)
Synthesis of the ϰ‐Agonist CJ‐15,161 via a Palladium‐Catalyzed Cross‐Coupling Reaction. (2002) (0)
State of Union Message from RBI (1989) (0)
Diastereoselective Synthesis of Pyrrolidines and Prolines (2006) (0)
Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007 (2013) (0)
A brief note on literacy and education in West Bengal (2003) (0)
Structure-Based Design of Protein Kinase Inhibitors (2015) (0)
Protein Kinase Inhibitor Drugs for Targeted Cancer Therapy: Design and Discovery of Imatinib, Nilotinib, Bafetinib, and Dasatinib (2015) (0)
Hiv protease inhibitor useful for treatment of aids (1992) (0)
Crystal Structure Analysis of HIV-1 Protease Mutant I84V with a Potent Non-peptide Inhibitor (UIC-94017) (2004) (0)
Inhibitors of memapsin 2, and their use (2000) (0)
C++ Soluations For Mathematical Problems (2005) (0)
Crystal structure analysis of HIV-1 protease with a inhibitor saquinavir (2007) (0)
Stereoselective Synthesis of 5-O-Carbamoylpolyoxamic Acid by [2,3]-Wittig—Still Rearrangement. (2000) (0)
Convenient Synthesis of Bicyclic Lactones Related to the Trichothecenes. (1989) (0)
MICROTUBULE STABILIZING COMPOUNDS CROSS REFERENCE TO RELATED APPLICATIONS (2017) (0)
Julia Olefination as a General Route to Phenyl (alpha-Fluoro)vinyl Sulfones. (2008) (0)
Arun Ghosh, compiled. Research notes and documents collected by the late Prodyot Mukherjee. Calcutta : with editorial assistance from Sobhantal Dutta Gupta, Indrani Ray, Centre for Studies in Social Sciences, 1977. (Occasional Paper ; no. 13) (1978) (0)
Index to Volume 38 (2008) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-015 (2016) (0)
Protein X‐Ray Crystallography in Structure‐Based Drug Design (2015) (0)
Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group (2012) (0)
Highly Diastereoselective asymmetric syn-aldol reactions of (R)-(N-tosyl)phenylalaninol propionate-derived titanium enolate and bidentate aromatic and aliphatic aldehydes (2022) (0)
From Holmes to Sherlock: Confession, Surveillance, and the Detective (2013) (0)
Total Synthesis and Structural Revision of (+)‐Amphidinolide W. (2004) (0)
Metabolism‐Directed Structure Optimization of Benzimidazole‐Based F. Tularensis Enoyl‐Reductase (FabI) Inhibitors (2013) (0)
Book Review: Fifty Years of Bretton Woods Twins (IMF and World Bank) (1996) (0)
Structure-Based Design of Non-Peptide HIV Protease Inhibitors (2010) (0)
Potent HIV Protease Inhibitors: The Development of Tetrahydrofuranylglycines as Novel P2‐Ligands and Pyrazine. Amides as P3‐Ligands. (1993) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-087-13 (2019) (0)
Indian political movement, 1919-1971 : a systematic bibliography (1976) (0)
Design of Metalloprotease Inhibitors (2015) (0)
Oil Imperialism, OiI Politics and Development Economics (1992) (0)
Intramolecular Acylation During Acid Chloride Formation of Some o- Styryl Phenoxyacetic Acids. (1992) (0)
Front Cover: Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants (ChemMedChem 8/2018) (2018) (0)
Kinetic and crystallographic analyses of SARS coronavirus 3CLpro inhibitors (2005) (0)
X-ray crystal structure of darunavir-resistant-P51 HIV-1 protease in complex with GRL-142 (2019) (0)
Synthesis of (+)-Jasplakinolide (2007) (0)
Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies (2022) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-084-13 (2019) (0)
Enantioselective Total Synthesis of Macrolide Antitumor Agent (‐)‐Lasonolide A (I). (2007) (0)
Black Money Clout and Indira Vikas Patra (1986) (0)
UIC-94017/TMC114: A Novel Nonpeptidic Protease Inhibitor Containing bis-Tetrahydrofuranyl Urethane (bis-THF) Potent against Multi-PI-Resistant HIV In Vitro (2005) (0)
Rural employment programmes : longitudinal analysis (1990) (0)
Assignment of Absolute Stereochemistry and Total Synthesis of (‐)‐Spongidepsin. (2004) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-063 (2020) (0)
Index to Volumes 32 & 33 (2003) (0)
DECARBOXYLATION OF ALKYLIDENE CYANO-ESTERS (1979) (0)
U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors (2021) (0)
A New and Simple Synthetic Approach to Functionalized Sulfone Derivatives by the Suzuki—Miyaura Cross‐Coupling Reaction. (2006) (0)
Enantioselective Synthesis of (+)-Cryptophycin 52 (LY355703) (I), a Potent Antimitotic Antitumor Agent. (2004) (0)
Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s (2019) (0)
Globalization and its discontents (2004) (0)
Highly Diastereoselective anti-Aldol Reactions Utilizing the Titanium Enolate of cis-2-Arylsulfonamido-1-acenaphthenyl Propionate. (2003) (0)
Four decades of continuing innovations in the development of antiretroviral therapy for HIV/AIDS: Progress to date and future challenges (2023) (0)
Abstract 2117: Lasonolide A-induced premature chromosome condensation is mediated by the proto-oncogene c-Raf (Raf1). (2013) (0)
India Response to Glasnost (1988) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-142 (2017) (0)
A Short Synthesis of (.+-.)-Eburnamonine. (2000) (0)
Whether the Indian Village Whithers (2005) (0)
Design of Cysteine Protease Inhibitors (2015) (0)
First Total Synthesis of (+)‐Amphidinolide T1 (2005) (0)
(Bicyclo[2.2.1]hepta-2,5-diene)[(2S ,3S )-bis(diphenylphosphino)butane]rhodium Perchlorate (2019) (0)
TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids. (2005) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-002 (2020) (0)
A Convenient Synthesis of (3S,3aR,5R,7aS,8S)-Hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-ol, a High-Affinity Nonpeptidyl Ligand for Highly Potent HIV-1 Protease Inhibitors (2022) (0)
Direct Synthesis of 8-Fluoro Purine Nucleosides via Metalation—Fluorination. (2008) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003 (2019) (0)
Proteasome Inhibitors for the Treatment of Relapsed Multiple Myeloma: Design and Discovery of Bortezomib and Carfilzomib (2015) (0)
Crystal structure analysis of HIV-1 protease mutant I84V with a inhibitor saquinavir (2007) (0)
Crystal structure of wild type HIV-1 protease in complex with darunavir (2013) (0)
High‐Yield Synthesis of Fluorinated Benzothiazolyl Sulfones: General Synthons for Fluoro‐Julia Olefinations. (2006) (0)
TiCl4‐Promoted Multicomponent Reaction: A New Entry to Functionalized α‐Amino Acids. (2005) (0)
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity (2020) (0)
Ethnonationalism : Indian experience (1991) (0)
Phosphine‐Mediated [4 + 2] Annulation of Bis(enones): A Lewis Base Catalyzed “Mock Diels—Alder” Reaction. (2004) (0)
Poverty, Surplus Labour and Development Strategies (1997) (0)
FROM THE IVORY TOWER (1987) (0)
EVALUATIOOF AXIOLYTIC AD MUSCLE RELAXAT EFFECT OF POLYHERBAL FORMULATIOOF CURCUMA LOGA AD BUTEA FRODOSA ORATS (2011) (0)
Total Synthesis of (f)-Ginkgolide B (1988) (0)
PenetrationMay Allow Blood-Brain Barrier and Possess Favorable Lipophilicity Vitro In Replication of Multi-PI-Resistant HIV-1 Protease Inhibitors (PIs) That Inhibit the Difluoride-Containing Nonpeptidic HIV-1 GRL-04810 and GRL-05010, (2014) (0)
EVALUATIO OF A XIOLYTIC A D MUSCLE RELAXA T EFFECT OF POLYHERBAL FORMULATIO OF CURCUMA LO GA A D BUTEA FRO DOSA O RATS (2012) (0)
Synthesis of Highly Constrained Unusual α-Amino Acid Derivative (III) by the Diels—Alder Approach. (2002) (0)
Synthesis of (-)-Zampanolide (2011) (0)
Introduction to Transducers (2015) (0)
Design of Proteasome Inhibitors (2015) (0)
Structure of Beta-Secretase Complexed with Inhibitor (2000) (0)
Hiv protease inhibitor having polyether substituent at n-terminal (1992) (0)
Analysis of Amyloid Precursor Protein Processing Protease β‐Secretase: Tools for Memapsin 2 (β‐Secretase) Inhibition Studies (2005) (0)
Stereoselective Synthesis of Pseudopeptide Microbial Agent Al-77-B (I). (2001) (0)
Further Thoughts on Import Liberalisation (1987) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-121 (2017) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-004 (2020) (0)
Economic Adjustment: A Programme for the Medium Term (1992) (0)
Synthesis of 9,10‐Diarylanthracene Derivatives via bis Suzuki—Miyaura Cross‐Coupling Reaction. (2002) (0)
High Resolution HIV-2 Protease Structure in Complex with Clinical Drug Darunavir (2008) (0)
Corrigendum to “Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114” [J. Mol. Biol. 363 (2006) 161–173] (2007) (0)
N,N′‐Disuccinimidyl Carbonate (2008) (0)
Exploring the structural determinants for inhibitor selectivity towards the BACE protein family using structure-based molecular design (2022) (0)
Formal Synthesis of (±)-Platencin (2010) (0)
Evaluation of Darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. (2023) (0)
Palladium‐Catalyzed Synthesis of N‐Aryloxazolidinones from Aryl Chlorides. (2003) (0)
Non‐Nucleoside HIV Reverse Transcriptase Inhibitors for the Treatment of HIV/AIDS: Design and Development of Etravirine and Rilpivirine (2015) (0)
Synthesis of CJ-15,161 via Cu-Catalyzed N-Arylation (2006) (0)
Capital Stock, Capital Consumption and the Capital Output Ratio (1989) (0)
X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-001 (2020) (0)
DDI Disquieting Disorientation of India (1987) (0)
India s Crumbling Data System (1997) (0)
Book Reviews (1989) (0)
Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation (2023) (0)
X-ray crystal structure of darunavir-resistant HIV-1 protease (P30) in complex with GRL-003 (2020) (0)
Corrigendum to “Enantioselective synthesis of cyclopentyltetrahydrofuran (Cp-THF), an important high-affinity P2-ligand for HIV-1 protease inhibitors”: [Tetrahedron Lett. 49 (2008) 3409] (2008) (0)
Crystal Structure Analysis of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) (2004) (0)
Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B (Ia) and Arenastatin A (Ib). (2004) (0)
Marxism and the Microchip (1989) (0)
Catalytic function and substrate specificity of alpha and beta coronavirus papain-like proteases: targeting human NL63, SARS-CoV and SARS-CoV-2 (Covid-19) with designed inhibitors (2022) (0)
The marine compound Lasonolide A is a potent inducer of premature chromosome condensation and inhibitor of cell adhesion (2007) (0)
Introduction (2000) (0)
Arts funding in India: hard times require furious dancing (2013) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-0476 (2016) (0)
Afforestation A Long and Difficult Haul (1988) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-097 (2016) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001 (2019) (0)
In Vitro Multi-PI-Resistant HIV-1 Variants Replication of a Wide Spectrum of Protease Inhibitor (PI), Potently Suppresses Ligand-Containing Nonpeptidic HIV-1 GRL-0519, a Novel Oxatricyclic (2014) (0)
Fitness test and methods for reducing HIV resistance to therapy (1999) (0)
X-ray crystal structure of wild type HIV-1 protease in complex with GRL-09510 (2017) (0)
Structure‐Based Design Strategies for Targeting G‐Protein‐Coupled Receptors (GPCRs) (2015) (0)
Unsteady flow of a viscoelastic Maxwell fluid in a channel bounded by two concentric circular arcs under a radial magnetic field (1974) (0)
Markets: Evolution, Limits and Relationship to Governance (2020) (0)
Renin Inhibitor for the Treatment of Hypertension: Design and Discovery of Aliskiren (2015) (0)
Asymmetric Diels–Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors (2019) (0)
Equality and Universality : Essays in Social and Political Theory (2003) (0)
From Traditional Medicine to Modern Drugs: Historical Perspective of Structure‐Based Drug Design (2015) (0)
A Convergent Synthesis of Carbocyclic Sinefungin (Ia) and Its C-5 Epimer (Ib). (2015) (0)
Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL008 (2013) (0)
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL0519 (2016) (0)
NEUTRON ENERGY LEVELS IN A DIFFUSE POTENTIAL (1960) (0)
What Is Sauce for the Goose Is Not Sauce for the Gander (1993) (0)
Book Reviews (1989) (0)
Agrarian structure and peasant movements in colonial and post-independence India: An annotated bibliography (1990) (0)
Procede de preparation de ligands de recepteurs de la thyroide derives d'aniline (2002) (0)
Crystal structure of wild type HIV-1 protease in complex with GRL-10413 (2016) (0)
Correction to Enantioselective Total Synthesis of (+)-Amphirionin-4. (2016) (0)
Ester Derived Titanium Enolate Aldol Reaction: Highly Diastereoselective Synthesis of syn‐ and anti‐Aldols. (1998) (0)

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Purdue University