Isabelle Aubert
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Mathematics Computer Science
Isabelle Aubert's Degrees
- PhD Computer Science Université Paris Cité
- Masters Computer Science Université Paris Cité
- Bachelors Mathematics Université Paris Cité
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Why Is Isabelle Aubert Influential?
(Suggest an Edit or Addition)According to Wikipedia, Isabelle Aubert is a Canadian neuroscientist with expertise in developing regenerative therapies for neurodegenerative disorders . She is a senior scientist at Sunnybrook Research Institute , and is a professor in laboratory medicine and pathobiology at the University of Toronto. In 2019, Aubert was appointed as a Canada Research Chair in Brain Repair and Regeneration.
Isabelle Aubert's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. (1995) (613)
- Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound (2018) (468)
- Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases (1992) (330)
- Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease (2010) (307)
- Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound (2013) (242)
- First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound (2019) (238)
- Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier (2011) (233)
- Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. (2014) (210)
- Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired (1995) (210)
- Regeneration in the adult mammalian CNS: guided by development (1995) (146)
- Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. (2012) (144)
- Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice (2014) (115)
- p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain (2010) (112)
- Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors, in the rat brain (1996) (108)
- Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease. (1989) (98)
- Cholinergic markers in aged cognitively impaired long-evans rats (1995) (84)
- The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging (2018) (84)
- Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation (1998) (79)
- Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus (2008) (70)
- Gene delivery to the spinal cord using MRI-guided focused ultrasound (2015) (61)
- Glymphatics Visualization after Focused Ultrasound‐Induced Blood–Brain Barrier Opening in Humans (2019) (60)
- Comparative laminar distribution of various autoradiographic cholinergic markers in adult rat main olfactory bulb (1995) (58)
- Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model. (2012) (58)
- Characterization and autoradiographic distribution of [3H]AF-DX 384 binding to putative muscarinic M2 receptors in the rat brain. (1992) (56)
- Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes* (2011) (54)
- The Benefits of Exercise and Metabolic Interventions for the Prevention and Early Treatment of Alzheimer's Disease. (2016) (52)
- Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampus (2012) (47)
- Stem cell transplantation for neurometabolic and neurodegenerative diseases (2010) (47)
- The length of hippocampal cholinergic fibers is reduced in the aging brain (2008) (47)
- Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability (2016) (46)
- Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions (1994) (44)
- Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria–fornix lesion (1998) (42)
- Noninvasive delivery of an α‐synuclein gene silencing vector with magnetic resonance–guided focused ultrasound (2018) (41)
- Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease (2018) (40)
- MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors (2021) (36)
- Polysialic acid limits choline acetyltransferase activity induced by brain‐derived neurotrophic factor (2006) (35)
- Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease (2020) (34)
- Sodium/myo-Inositol Transporters: Substrate Transport Requirements and Regional Brain Expression in the TgCRND8 Mouse Model of Amyloid Pathology (2011) (33)
- Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease. (2020) (32)
- A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer's Disease. (2016) (32)
- Autoradiographic distribution of putative muscarinic receptor sub-types in mammalian brain. (1993) (31)
- Developmental profiles of various cholinergic markers in the rat main olfactory bulb using quantitative autoradiography (1996) (30)
- Disrupting the blood–brain barrier with focused ultrasound: Perspectives on inflammation and regeneration (2017) (28)
- Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer’s disease (2018) (28)
- Neurochemical Deficits in Pathological Brain Aging: Specificity and Possible Relevance for Treatment Strategies (1990) (26)
- Endothelial cells regulate p53-dependent apoptosis of neural progenitors after irradiation (2012) (25)
- MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain. (2019) (25)
- Loss of Neuronal Protein Expression in Mouse Hippocampus After Irradiation (2010) (23)
- Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease (2019) (20)
- Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats. (2009) (20)
- Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound (2018) (19)
- Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice. (2012) (18)
- Overexpression of the vesicular acetylcholine transporter enhances dendritic complexity of adult-born hippocampal neurons and improves acquisition of spatial memory during aging (2015) (18)
- B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments (2013) (18)
- Abrogation of early apoptosis does not alter late inhibition of hippocampal neurogenesis after irradiation. (2010) (17)
- P53 regulates disruption of neuronal development in the adult hippocampus after irradiation (2016) (15)
- Miniaturized electrochemical system for cholinesterase inhibitor detection. (2013) (14)
- Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice (2014) (14)
- The cell adhesion molecule L1 regulates the expression of choline acetyltransferase and the development of septal cholinergic neurons (2011) (13)
- 5th International Symposium on Focused Ultrasound (2016) (13)
- A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles (2014) (13)
- Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand (2009) (13)
- Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia (2020) (12)
- Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery (2021) (11)
- Apolipoprotein E4 and Cholinergic Dysfunction in Alzheimer’s Disease (1994) (11)
- Apolipoprotein E4, Cholinergic Integrity, Synaptic Plasticity and Alzheimer’s Disease (1996) (10)
- Polysialic acid limits septal neurite outgrowth on laminin (2007) (10)
- Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies (2021) (10)
- The human brain endothelial barrier: transcytosis of AAV9, transduction by AAV2 (2017) (9)
- Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease (2016) (8)
- Vaccine Development for Alzheimers Disease (2006) (8)
- Vaccine development for Alzheimer's disease. (2006) (8)
- Focused ultrasound: crossing barriers to treat Alzheimer's disease. (2011) (7)
- Vasculotide restores the blood-brain barrier after focused ultrasound-induced permeability in a mouse model of Alzheimer's disease (2021) (7)
- scyllo-inositol (ELND005) ameliorates amyloid pathology in an aggressive mouse model of Alzheimer's disease (2009) (6)
- Autoradiographic Distribution of Nicotinic Receptor Sites Labelled with [3H]Cytisine in the Human Brain (1995) (5)
- Transgene distribution and immune response following focused ultrasound delivery to the brain of rAAV9 and PHP.B in a mouse model of Alzheimer disease (2021) (5)
- Cell adhesion molecule L1 promotes neurite outgrowth of septal neurons (2004) (5)
- Gene Transfer for Adult CNS Regeneration and Aging (1998) (5)
- Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis (2021) (4)
- The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis (2020) (4)
- Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas. (2022) (4)
- Breached Barriers: A Scoping Review of Blood-Central Nervous System Barrier Pathology in Amyotrophic Lateral Sclerosis (2022) (4)
- Sex differences in long-term fear and anxiety-like responses in a preclinical model of PTSD. (2022) (3)
- Therapeutic effects of focused ultrasound-mediated blood-brain barrier opening in a mouse model of Alzheimer’s disease (2015) (3)
- The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites (2022) (3)
- Viral alpha-synuclein knockdown prevents spreading synucleinopathy (2021) (3)
- Intravenous and Non-invasive Drug Delivery to the Mouse Basal ForebrainUsing MRI-guided Focused Ultrasound. (2021) (2)
- EVALUATION OF EFFECTS OF PHYSICAL EXERCISE ON VASCULAR AND CEREBRAL PATHOLOGY, PLASTICITY AND FUNCTION IN A MOUSE MODEL OF ALZHEIMER'S DISEASE (2016) (2)
- MORPHIOUS: an unsupervised machine learning workflow to detect the activation of microglia and astrocytes (2022) (2)
- Nicotinic acetylcholine receptors are decreased in rat dentate gyrus following entorhinal cortex lesions (1992) (2)
- MORPHIOUS: A Machine Learning Workflow to Naively Detect the Activation of Microglia and Astrocytes (2020) (1)
- Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound. (2023) (1)
- Ultrasound Delivery of an Anti-Aβ Therapeutic Agent to the Brain in a Mouse Model of Alzheimer’s Disease (2009) (1)
- Two-photon microscopy for real-time monitoring of focused ultrasound-mediated drug delivery to the brain in a mouse model of Alzheimer's disease (2013) (1)
- Apolipoprotein E4 and Cholinergic Activity in Alzheimer’s Disease (1997) (1)
- Delivery of stem cells to the brain: potential for treatment of neurodegenerative disease (2015) (1)
- Effects of voluntary exercise on cognition, neurogenesis, and plaque load in a mouse model of Alzheimers disease. (2013) (1)
- The therapeutic potential of nerve growth factor combined with blood-brain barrier modulation by focused ultrasound for neurodegenerative disorders (2021) (1)
- Withdrawal: Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. (2020) (1)
- [3H]AF-DX 384/muscarinic-M2 receptor binding sites are increased in certain cortical brain regions of aged memory-impaired as compared to memory-unimpaired rats☆ (1993) (1)
- FOCUSED ULTRASOUND-MEDIATED DELIVERY OF NATURAL ANTIBODIES TO THE BRAIN FACILITATES NEURONAL PLASTICITY IN AN AMYLOIDOSIS MOUSE MODEL (2016) (0)
- Anti-amyloid beta treatments: can they promote cholinergic survival and neurogenesis? (2009) (0)
- The age-memory impaired rat: A model to study cholinergic functions in old age and the potential usefulness of M2-cholinergic antagonists to reverse cognitive impairments (1995) (0)
- Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease (2018) (0)
- MRI-guided focused ultrasound for local delivery of anti-Aβ antibodies in a mouse model of Alzheimer's disease (2010) (0)
- Delivery of stem cells to the brain using MRIgFUS (2011) (0)
- VASCULOTIDE TREATMENT ACCELERATES BLOOD-BRAIN BARRIER RESTORATION AFTER FOCUSED ULTRASOUND IN A MOUSE MODEL OF ALZHEIMER'S DISEASE (2016) (0)
- MORPHIOUS: an unsupervised machine learning workflow to detect the activation of microglia and astrocytes (2022) (0)
- Insights and Lessons from a Scientific Conference on Non-Invasive Delivery of Macromolecules (2017) (0)
- INVESTIGATING MULTI-THERAPEUTIC AMYLOID STRATEGIES FOR TREATING ALZHEIMER’S DISEASE (2016) (0)
- Plagl1 is part of the mammalian retinal injury response and a critical regulator of Müller glial cell quiescence (2021) (0)
- APOLIPOPROTEIN E 4 AND CHOLINERGIC ACTIVITY IN ALZHEIMER ' S DISEASE (0)
- THE MODULATION OF PATHOLOGY AND REGENERATION BY FOCUSED ULTRASOUND IN A MOUSE MODEL OF ALZHEIMER’S DISEASE (2018) (0)
- NOVEL COMBINATION TREATMENT FOR ALZHEIMER’S DISEASE PROMOTES HIPPOCAMPAL NEUROGENESIS IN TGCRND8 MICE (2016) (0)
- Anesthetic‐loaded nanodroplets with focused ultrasound reduces agitation in Alzheimer's mice (2023) (0)
- NEURON-SPECIFIC TRANSGENE DELIVERY TO THE BRAIN USING MRI-GUIDED FOCUSED ULTRASOUND (2016) (0)
- Quantification of cholinergic degeneration and adult neurogenesis in TgCRND8 mice following treatment with scyllo-inositol (ELND005) (2009) (0)
- Sonoselective delivery using ultrasound and microbubbles combined with intravenous rAAV9 CLDN5-GFP does not increase endothelial gene expression. (2023) (0)
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