Austin Gerard Smith
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British stem cell biologist
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Biology
Austin Gerard Smith's Degrees
- Bachelors Biology University of Manchester
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Why Is Austin Gerard Smith Influential?
(Suggest an Edit or Addition)According to Wikipedia, Austin Gerard Smith is a professor at the University of Exeter and director of its Living Systems Institute. He is notable for his pioneering work on the biology of embryonic stem cells. Education Austin Smith obtained his doctoral degree from the University of Edinburgh in 1986.
Austin Gerard Smith's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells (2000) (3733)
- Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 (1998) (3465)
- Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells (2003) (3329)
- The ground state of embryonic stem cell self-renewal (2008) (3252)
- BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3 (2003) (2193)
- Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides (1988) (1945)
- Naive and primed pluripotent states. (2009) (1627)
- Nanog safeguards pluripotency and mediates germline development (2007) (1565)
- Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture (2003) (1535)
- Altered immune responses in mice lacking inducible nitric oxide synthase (1995) (1380)
- Nanog Is the Gateway to the Pluripotent Ground State (2009) (1046)
- Changing potency by spontaneous fusion (2002) (1015)
- Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. (2009) (950)
- Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005) (904)
- Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition (2008) (820)
- FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment (2007) (800)
- Capture of Authentic Embryonic Stem Cells from Rat Blastocysts (2008) (798)
- The Transcriptional and Epigenomic Foundations of Ground State Pluripotency (2012) (796)
- Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009) (761)
- Signalling, cell cycle and pluripotency in embryonic stem cells. (2002) (628)
- Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo (2009) (583)
- Self-renewal of teratocarcinoma and embryonic stem cells (2004) (567)
- Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human (2014) (559)
- HLA-A2.1–restricted Education and Cytolytic Activity of CD8+ T Lymphocytes from β2 Microglobulin (β2m) HLA-A2.1 Monochain Transgenic H-2Db β2m Double Knockout Mice (1997) (535)
- Generation of purified neural precursors from embryonic stem cells by lineage selection (1998) (490)
- Naïve pluripotency is associated with global DNA hypomethylation (2013) (477)
- Neuroepithelial Cells Supply an Initial Transient Wave of MSC Differentiation (2007) (412)
- The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification (2014) (394)
- Nanog promotes transfer of pluripotency after cell fusion (2006) (373)
- Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. (2009) (372)
- Capturing Pluripotency (2008) (363)
- The ground state of pluripotency. (2010) (361)
- Defined conditions for neural commitment and differentiation. (2003) (345)
- Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation (2002) (342)
- The nature of embryonic stem cells. (2014) (340)
- Essential function of LIF receptor in motor neurons (1995) (327)
- Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis (2015) (324)
- Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal (2012) (318)
- Formative pluripotency: the executive phase in a developmental continuum (2017) (304)
- Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation (2012) (298)
- Human Embryonic Stem Cells (2005) (297)
- Culture and differentiation of embryonic stem cells (1991) (297)
- Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation (2011) (292)
- Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells (2006) (291)
- Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass (2016) (289)
- Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3 (2013) (287)
- Phenotypic Complementation Establishes Requirements for Specific POU Domain and Generic Transactivation Function of Oct-3/4 in Embryonic Stem Cells (2002) (287)
- Reprogramming Efficiency Following Somatic Cell Nuclear Transfer Is Influenced by the Differentiation and Methylation State of the Donor Nucleus (2006) (282)
- Pluripotency in the embryo and in culture. (2012) (280)
- Adherent neural stem (NS) cells from fetal and adult forebrain. (2006) (275)
- Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage (1990) (273)
- Capture of Neuroepithelial-Like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for In Vitro Production of Human Neurons (2012) (263)
- Osteogenic and chondrogenic differentiation of embryonic stem cells in response to specific growth factors. (2005) (256)
- Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human (2014) (253)
- Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice (2003) (252)
- Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture (2008) (239)
- Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways (1994) (237)
- Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency (2010) (236)
- New prospects for human stem-cell therapy in the nervous system (1999) (232)
- Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and antilymphocytic choriomeningitis virus cytolytic responses (1999) (229)
- Treatment of a Mouse Model of Spinal Cord Injury by Transplantation of Human Induced Pluripotent Stem Cell‐Derived Long‐Term Self‐Renewing Neuroepithelial‐Like Stem Cells (2012) (221)
- Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor (2013) (216)
- The origin and identity of embryonic stem cells (2011) (210)
- Validated germline-competent embryonic stem cell lines from nonobese diabetic mice (2009) (209)
- Human hypoblast formation is not dependent on FGF signalling (2012) (206)
- Peripheral Demyelination and Neuropathic Pain Behavior in Periaxin-Deficient Mice (2000) (205)
- Mapping the route from naive pluripotency to lineage specification (2014) (200)
- Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells (1999) (197)
- A glossary for stem-cell biology (2006) (196)
- Epigenetic resetting of human pluripotency (2017) (193)
- Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause (2016) (188)
- A Schwann cell mitogen accompanying regeneration of motor neurons (1997) (187)
- Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis (1995) (184)
- Genetic Exploration of the Exit from Self-Renewal Using Haploid Embryonic Stem Cells (2014) (169)
- The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity (2012) (169)
- Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions (2011) (167)
- Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis (1996) (158)
- A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency (2010) (158)
- Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells (2002) (151)
- Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state (2010) (150)
- SoxB transcription factors specify neuroectodermal lineage choice in ES cells (2004) (146)
- Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency (2016) (145)
- Telomere directed fragmentation of mammalian chromosomes (1993) (144)
- Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles (2003) (138)
- CD133 (Prominin) Negative Human Neural Stem Cells Are Clonogenic and Tripotent (2009) (138)
- Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast (2018) (137)
- Stem cells: Fusion brings down barriers (2003) (134)
- Essential Alterations of Heparan Sulfate During the Differentiation of Embryonic Stem Cells to Sox1‐Enhanced Green Fluorescent Protein‐Expressing Neural Progenitor Cells (2007) (131)
- Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors (2010) (123)
- Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. (2013) (123)
- Otx2 and Oct4 Drive Early Enhancer Activation during Embryonic Stem Cell Transition from Naive Pluripotency (2014) (119)
- Leukemia Inhibitory Factor and Its Receptor Promote Adipocyte Differentiation via the Mitogen-activated Protein Kinase Cascade* (1999) (119)
- Tripotential Differentiation of Adherently Expandable Neural Stem (NS) Cells (2007) (118)
- Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development (2018) (118)
- The Liberation of Embryonic Stem Cells (2011) (109)
- Parameters influencing derivation of embryonic stem cells from murine embryos (2008) (106)
- Dynamics of gene silencing during X inactivation using allele-specific RNA-seq (2015) (106)
- JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency (2012) (102)
- Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency (2020) (102)
- Targeted Inactivation of the Mouse Locus Encoding Coagulation Factor XIII-A: Hemostatic Abnormalities in Mutant Mice and Characterization of the Coagulation Deficit (2002) (96)
- Regulation of stem cell therapies under attack in Europe: for whom the bell tolls (2013) (91)
- Naive stem cell blastocyst model captures human embryo lineage segregation (2021) (90)
- Human naive epiblast cells possess unrestricted lineage potential (2021) (88)
- Differentiation of Human Induced Pluripotent Stem Cells into Brown and White Adipocytes: Role of Pax3 (2014) (80)
- Germline potential of parthenogenetic haploid mouse embryonic stem cells (2012) (77)
- Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation (2019) (75)
- A Genome-Wide RNAi Screen Reveals MAP Kinase Phosphatases as Key ERK Pathway Regulators during Embryonic Stem Cell Differentiation (2012) (74)
- Genesis of embryonic stem cells. (2003) (73)
- A PiggyBac-Based Recessive Screening Method to Identify Pluripotency Regulators (2011) (70)
- Stem Cells Expanded from the Human Embryonic Hindbrain Stably Retain Regional Specification and High Neurogenic Potency (2013) (69)
- A structurally defined mini-chromosome vector for the mouse germ line (2000) (68)
- Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos (2010) (66)
- Rebuilding Pluripotency from Primordial Germ Cells (2013) (66)
- NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State (2016) (65)
- Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro (2011) (65)
- The mammalian germline as a pluripotency cycle (2013) (64)
- The Cell-Surface Marker Sushi Containing Domain 2 Facilitates Establishment of Human Naive Pluripotent Stem Cells (2019) (62)
- Defined conditions for propagation and manipulation of mouse embryonic stem cells (2019) (61)
- Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency (2019) (61)
- Robust Self-Renewal of Rat Embryonic Stem Cells Requires Fine-Tuning of Glycogen Synthase Kinase-3 Inhibition (2013) (61)
- Interplay of cell–cell contacts and RhoA/MRTF‐A signaling regulates cardiomyocyte identity (2018) (60)
- Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation (2008) (56)
- Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential (2020) (55)
- A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1 (2013) (54)
- Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells (2011) (53)
- Pluripotency Deconstructed (2018) (48)
- A method to identify and analyze biological programs through automated reasoning (2016) (48)
- Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis (2019) (46)
- The Battlefield of Pluripotency (2005) (41)
- Nanog Heterogeneity: Tilting at Windmills? (2013) (40)
- Automated Large-Scale Culture and Medium-Throughput Chemical Screen for Modulators of Proliferation and Viability of Human Induced Pluripotent Stem Cell–Derived Neuroepithelial-like Stem Cells (2013) (39)
- The Art of Capturing Pluripotency: Creating the Right Culture (2017) (39)
- Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid (2012) (38)
- Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency (2019) (38)
- Unequal segregation of parental chromosomes in embryonic stem cell hybrids (2005) (37)
- A Model-Based Analysis of Culture-Dependent Phenotypes of mESCs (2014) (36)
- Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells (2015) (35)
- Esrrb Complementation Rescues Development of Nanog-Null Germ Cells (2018) (35)
- Regulatory factors of embryonic stem cells (1988) (34)
- Exploitation of adherent neural stem cells in basic and applied neurobiology. (2006) (33)
- Culture parameters for stable expansion, genetic modification and germline transmission of rat pluripotent stem cells (2011) (33)
- Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions (2012) (30)
- Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm (1996) (29)
- A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation (2017) (29)
- Convergence of cMyc and β‐catenin on Tcf7l1 enables endoderm specification (2015) (28)
- Imaging-based chemical screens using normal and glioma-derived neural stem cells. (2010) (28)
- Long-Term Perfusion Culture of Monoclonal Embryonic Stem Cells in 3D Hydrogel Beads for Continuous Optical Analysis of Differentiation. (2019) (27)
- A common molecular logic determines embryonic stem cell self‐renewal and reprogramming (2018) (25)
- Neural stem cells engrafted in the adult brain fuse with endogenous neurons. (2013) (25)
- Negative feedback via RSK modulates Erk‐dependent progression from naïve pluripotency (2018) (23)
- Trophectoderm Potency is Retained Exclusively in Human Naïve Cells (2020) (22)
- Looking inwards: opening a window onto human development (2015) (20)
- Correction: Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast (doi: 10.1242/dev.158501) (2018) (20)
- Growth and differentiation factors of pluripotential stem cells (1990) (19)
- Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency (2021) (18)
- Comparison of ν μ - Ar multiplicity distributions observed by MicroBooNE to GENIE model predictions: MicroBooNE Collaboration (2018) (17)
- Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2 (2019) (15)
- Design principles of pluripotency (2009) (14)
- Cancer-Related Mutations Are Not Enriched in Naive Human Pluripotent Stem Cells (2020) (13)
- 'No' to ban on stem-cell patents (2011) (13)
- Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021) (11)
- An unpaired mouse centromere passes consistently through male meiosis and does not significantly compromise spermatogenesis (2003) (11)
- Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells (2011) (11)
- Pluripotent stem cells: private obsession and public expectation (2010) (11)
- Differential stability of a human mini-chromosome in mouse cell lines (1998) (10)
- Brain Cancer Stem Cells: A Level Playing Field (2009) (10)
- Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo Reporters (2017) (9)
- Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency (2021) (9)
- NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation (2022) (8)
- HLA-A2.1-restricted education and cytolytic activity of CD8+ T lymphocytes from β2m-HLA-A2.1 monochain-transgenic, H-2Db, β2m double knock-out mice (1997) (8)
- Embryonic stem cells commit to differentiation by symmetric divisions following a variable lag period (2020) (7)
- Cell state transitions: definitions and challenges (2021) (7)
- A conceptual and computational framework for modelling and understanding the non-equilibrium gene regulatory networks of mouse embryonic stem cells (2017) (7)
- Correction: Epigenetic resetting of human pluripotency (doi:10.1242/dev.146811) (2018) (7)
- Correction: Defined conditions for propagation and manipulation of mouse embryonic stem cells (doi:10.1242/dev.173146) (2019) (6)
- Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory (2020) (6)
- Growth and Differentiation Factors of Embryonic Stem Cells (1989) (6)
- Differentiation and gene regulation Programming, reprogramming and regeneration (2003) (5)
- Efficient RNA-mediated reprogramming of human somatic cells to naïve pluripotency facilitated by tankyrase inhibition (2019) (5)
- Colloquium Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox 1 – gfp knockin mice (2003) (5)
- LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein (2018) (5)
- GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells (2020) (5)
- A common molecular logic determines embryonic stem cell self-renewal and reprogramming (2017) (4)
- Cell biology: Potency unchained (2014) (4)
- Cooperative genetic networks drive a mammalian cell state transition (2020) (4)
- In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells (2019) (4)
- Stem cells and regeneration: a special issue (2013) (3)
- 10 Embryonic Stem Cells (2001) (2)
- Single-cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development (2018) (2)
- LIF / Stat 3 directly promotes mitochondrial respiration during maintenance and induction of naive pluripotency (2016) (1)
- Microfluidic platform for live cell imaging of 3D cultures with clone retrieval (2020) (1)
- Genetic analysis of embryonal carcinoma cells (1986) (1)
- NMD is required for timely cell fate transitions by fine-tuning gene expression and controlling translation (2020) (1)
- Suppression of YAP safeguards human naïve pluripotency (2022) (1)
- Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq (2016) (1)
- De novo DNA methylation suppresses aberrant fate determination during pluripotency transition (2020) (1)
- HLA-A2.1–restricted Education and Cytolytic Activity of CD8 (cid:2) T Lymphocytes from (cid:3) 2 Microglobulin ( (cid:3) 2m) HLA-A2.1 Monochain Transgenic H-2D b (cid:3) 2m Double Knockout Mice (2002) (1)
- Human embryonic stem cells: prospects for human health - a 1-day international symposium held at the University of Sheffield. (2002) (1)
- 17-P013 Consequences and applications of suppression of Erk signalling in early mouse embryos (2009) (0)
- 2043–2051 HLA-A2.1–restricted Education and Cytolytic Activity of CD8 (cid:2) T Lymphocytes from (cid:3) 2 Microglobulin ( (cid:3) 2m) HLA-A2.1 Monochain Transgenic H-2D b (cid:3) 2m Double Knockout (2002) (0)
- Manipulating embryonic stem cells (1998) (0)
- TMOD-11. HUMAN STEM CELL BASED MODEL OF MEDULLOBLASTOMA (2017) (0)
- 17-P041 Transcriptome analysis of FGF signalling in embryonic stem cells (2009) (0)
- The differentiation of ES cells into neuroectodermal precursors is associated with an increase in the levels and sulfation of heparan sulfate proteoglycans (2004) (0)
- Explorer Interplay between FGF 2 and BMP controls the self-renewal , dormancy and differentiation of rat neural stem cells (2016) (0)
- Author response: A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation (2017) (0)
- Mouse and human induced pluripotent stem cells as a source for multipotent Isl1<sup>+</sup> cardiovascular progenitors (2010) (0)
- Dynamics of gene silencing during X inactivation using allele-specific RNA-seq (2015) (0)
- Cell state transitions: catch them if you can. (2023) (0)
- GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells (2020) (0)
- Assembly of haem cofactors into diverse haemoproteins (2002) (0)
- Piano Play In (Program) (2005) (0)
- Biophysical models of early mammalian embryogenesis (2023) (0)
- A lncRNA/Lin28/Mirlet7 axis coupled to DNA methylation fine tunes the dynamics of a cell state transition (2017) (0)
- Human embryonic stem cells [1] (2005) (0)
- the russians are coming (2014) (0)
- Pluripotenzdeterminierende factors and their application (2003) (0)
- The blueprint of primate preimplantation development (2017) (0)
- Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal (2013) (0)
- Retraction Note (2014) (0)
- Tracking exit from naive pluripotency using the Rex 1 : GFPd 2 reporter (2014) (0)
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