Avram Goldstein
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American teacher
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Chemistry
Why Is Avram Goldstein Influential?
(Suggest an Edit or Addition)According to Wikipedia, Avram Goldstein was a professor of pharmacology who was one of the discoverers of endorphins and a noted expert on addiction. Goldstein established the Pharmacology Department at Stanford University School of Medicine. He was awarded the Franklin Medal and was elected to the National Academy of Sciences. He was an atheist.
Avram Goldstein's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Purification and properties (1975) (2402)
- Dynorphin is a specific endogenous ligand of the kappa opioid receptor. (1982) (1120)
- Dynorphin-(1-13), an extraordinarily potent opioid peptide. (1979) (793)
- Opioid peptides and opioid receptors in cells of the immune system. (1988) (443)
- Multiple opioid receptors: ligand selectivity profiles and binding site signatures. (1989) (440)
- Cloning and pharmacological characterization of a rat kappa opioid receptor. (1993) (420)
- Dynorphin and vasopressin: common localization in magnocellular neurons. (1982) (414)
- Opioid peptides endorphins in pituitary and brain. (1976) (413)
- Thrills in response to music and other stimuli (1980) (401)
- Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. (1971) (385)
- Specific receptor for the opioid peptide dynorphin: structure--activity relationships. (1981) (376)
- Sequence and expression of the rat prodynorphin gene. (1985) (363)
- The Fundamental Concepts of Pharmacology. (Book Reviews: Principles of Drug Action. The Basis of Pharmacology) (1970) (363)
- Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide. (1981) (344)
- Dynorphin immunocytochemistry in the rat central nervous system (1982) (311)
- Stereospecific nicotine receptors on rat brain membranes. (1980) (310)
- A peptide-like substance from pituitary that acts like morphine. I. Isolation. (1975) (282)
- Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity. (1983) (279)
- Comparison of the distribution of dynorphin systems and enkephalin systems in brain. (1982) (265)
- The interactions of drugs and plasma proteins. (1949) (260)
- Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin. (1976) (237)
- Partial antagonism of placebo analgesia by naloxone (1983) (230)
- Site-directed alkylation of multiple opioid receptors. I. Binding selectivity. (1984) (198)
- Endorphins: naloxone fails to alter experimental pain or mood in humans. (1978) (197)
- Immunoreactive dynorphin in pituitary and brain. (1980) (187)
- Immunoreactive dynorphin in mammalian spinal cord and dorsal root ganglia. (1981) (173)
- Antinociception and paralysis induced by intrathecal dynorphin A. (1985) (171)
- Nicotine self‐administration in rats (1984) (161)
- Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects. (1977) (158)
- Heroin addicts and methadone treatment in Albuquerque: a 22-year follow-up. (1995) (152)
- Dynorphin is a specific endogenous ligand of the κ opioid receptor Science, 215 (1982) 413–415 (1982) (150)
- Morphine‐tolerant longitudinal muscle strip from guinea‐pig ileum (1973) (150)
- Dynorphin immunocytochemical localization in brain and peripheral nervous system: preliminary studies. (1981) (149)
- On the role of endogenous opioid peptides: failure of naloxone to influence shock escape threshold in the rat. (1976) (146)
- The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats (2002) (145)
- Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin (2005) (139)
- Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus (1981) (132)
- Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus. (1984) (129)
- A specific radioimmunoassay for the novel opioid peptide dynorphin. (1980) (128)
- Failure of the opiate antagonist naloxone to modify hypnotic analgesia. (1975) (126)
- Binding selectivity profiles for ligands of multiple receptor types: Focus on opioid receptors (1987) (126)
- Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse. (1969) (125)
- Opioid peptides (endorphins) in pituitary and brain (1977) (125)
- Behavioral effects and in vivo degradation of intraventricularly administered dynorphin-(1-13) and D-Ala2-dynorphin-(1-11) in rats. (1980) (124)
- Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary (1983) (123)
- Morphine and other opiates from beef brain and adrenal. (1985) (116)
- Effect of synaptic transmission blockade on morphine action in the guinea-pig myenteric plexus. (1976) (112)
- Diurnal rhythm of plasma immunoreactive beta-endorphin and its relationship to sleep stages and plasma rhythms of cortisol and prolactin. (1981) (109)
- Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary. (1982) (107)
- Synthesis of the skeleton of the morphine molecule by mammalian liver (1987) (104)
- Multiple opioid receptors criteria for identification and classification (1984) (101)
- Tolerance to Opioid Narcotics: Time Course and Reversibility of Physical Dependence in Mice (1971) (100)
- Opioid receptor selectivity of dynorphin gene products. (1984) (100)
- Immunoreactive dynorphin in rat tissues and plasma (1983) (93)
- Effect of the opiate antagonist naloxone on body temperature in rats. (1975) (93)
- Partial purification of an opiate receptor from mouse brain (1974) (85)
- Pro-dynorphin peptides are found in the same neurons throughout rat brain: immunocytochemical study. (1983) (82)
- Morphine Tolerance and Supersensitivity to 5-Hydroxytryptamine in the Myenteric Plexus of the Guinea-pig (1973) (78)
- Morphine and codeine from mammalian brain. (1986) (76)
- Plasma beta-endorphin immunoreactivity in schizophrenia. (1979) (75)
- Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor. (1994) (71)
- Failure of hypophysectomy to alter brain content of opioid peptides (endorphins). (1976) (70)
- Regulation of insulin receptor functions by a peptide derived from a major histocompatibility complex class I antigen (1990) (68)
- A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties. (1975) (66)
- Molecular and Cellular Aspects of the Drug Addictions (1989) (64)
- Addiction: from biology to drug policy (1994) (64)
- Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain (1971) (63)
- Site-directed alkylation of multiple opioid receptors. II. Pharmacological selectivity. (1984) (63)
- The role of acetaldehyde in the central effects of ethanol. (2005) (62)
- Experimental alterations of endorphin levels in rat pituitary. (1979) (62)
- Alcohol Dependence and Opiate Dependence: Lack of Relationship in Mice (1971) (61)
- The effect of p-chlorophenylalanine on opiate-induced running, analgesia, tolerance and physical dependence in mice. (1971) (61)
- Heroin addiction: neurobiology, pharmacology, and policy. (1991) (59)
- Inactivity of narcotic glucuronides as analgesics and on guinea-pig ileum. (1972) (58)
- Stereospecific opiate binding in bovine adrenal medulla. (1979) (53)
- Effects of narcotic opiates and serotonin on the electrical behavior of neurons in the guinea pig myenteric plexus. (1974) (53)
- Reduction in opiate receptor reserve in morphine tolerant guinea pig ilea. (1982) (52)
- Analgesia induced by intrathecal injection of dynorphin B in the rat. (1984) (51)
- A dynorphin-like opioid in the central nervous system of an amphibian. (1982) (51)
- Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats. (2003) (50)
- Neurobiology of Opioids (1991) (49)
- Dynorphin converting enzyme with unusual specificity from rat brain. (1984) (49)
- Degradation of dynorphin-(1–13) by membrane-bound rat brain enzymes (1982) (48)
- A synthetic peptide with morphine-like pharmacologic action. (1975) (46)
- Naloxone effects on a nociceptive response of hypophysectomized and adrenalectomized mice. (1978) (46)
- Characterization of the receptor mediating the nicotine discriminative stimulus (2004) (42)
- Single neuron studies of opiate action in the guinea pig myenteric plexus. (1975) (42)
- Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands. (1992) (40)
- Localization of immunoreactive dynorphin in neurons cultured from spinal cord and dorsal root ganglia. (1982) (40)
- Endorphin from pituitary inhibits cyclic AMP formation in homogenates of neuroblastoma × glioma hybrid cells (1977) (39)
- Preparation of brain membranes containing a single type of opioid receptor highly selective for dynorphin. (1982) (39)
- Effects of eight-hour naloxone infusions on human subjects. (1983) (38)
- Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site. (1999) (37)
- Structural requirements for delta opioid receptor binding. (1987) (36)
- Characterization of big dynorphins from rat brain and spinal cord (1987) (34)
- Development and validation of a sensitive radioimmunoassay for naturally occurring beta-endorphin-like peptides in human plasma. (1980) (34)
- Failure of methadone and levomethadyl acetate (levo-alpha-acetylmethadol, LAAM) maintenance to affect memory. (1977) (32)
- A specific radioimmunoassay for the opioid peptide dynorphin B in neural tissues (1982) (32)
- Selectivity of dynorphin for κ opioid receptors (1982) (32)
- Endorphins in brains of decapitated and microwave-killed mice. (1977) (28)
- Blind Dosage Comparisons and Other Studies in a Large Methadone Program (1971) (28)
- Unsuccessful Attempts to Transfer Morphine Tolerance and Passive Avoidance by Brain Extracts (1971) (27)
- Further characterization of morphine-like peptides (endorphins) from pituitary (1976) (27)
- Regulation of receptor internalization by the major histocompatibility complex class I molecule. (1994) (26)
- Comments on the “Isolation, Identification and Synthesis of a Specific-behaviour-inducing Brain Peptide” (1973) (26)
- PLACEBO ANALGESIA, ENDORPHINS, AND NALOXONE (1978) (26)
- Some effects of naloxone on behavior in the mouse (1977) (24)
- Properties and behavior of purified human plasma cholinesterase. III. Competitive inhibition by prostigmine and other alkaloids with special reference to differences in kinetic behavior. (1951) (24)
- Levels of immunoreactive dynorphin in brain and pituitary of Brattleboro rats (1980) (23)
- Is there a relationship between DNA sequences encoding peptide ligands and their receptors? (1989) (23)
- Reversibility of morphine tolerance and dependence in guinea pig brain and myenteric plexus (1974) (23)
- Distribution of endorphins (peptides with morphine-like pharmacological activity) in pituitary (1977) (22)
- Opioid peptide dynorphin-(1–13): Adsorptive losses and potency estimates (1980) (22)
- Effects of morphine and levorphanol on brain acetylcholine content in mice. (1970) (22)
- ENDORPHINS: PHYSIOLOGY AND CLINICAL IMPLICATIONS * (1978) (21)
- Neuropeptide processing by single-step cleavage: conversion of leumorphin (dynorphin B-29) to dynorphin B. (1985) (20)
- "DAKLI": a multipurpose ligand with high affinity and selectivity for dynorphin (kappa opioid) binding sites. (1988) (19)
- Cataleptic effects of dynorphin-(1–13) in rats made tolerant to a mu opiate receptor agonist (1981) (19)
- Wakefulness caused by caffeine (1964) (19)
- Radioimmunoassays for β-endorphin: Comparison of properties of two antisera☆ (1978) (19)
- Correlation between insulin receptor occupancy and tyrosine kinase activity at low insulin concentrations and effect of major histocompatibility complex class I-derived peptide. (1993) (19)
- Two "big" dynorphins from porcine pituitary. (1982) (18)
- Properties and behavior of purified human plasma cholinesterase. IV. Enzymatic destruction of the inhibitors prostigmine and physostigmine. (1952) (17)
- Inhibition of insulin receptor phosphorylation by peptides derived from major histocompatibility complex class I antigens. (1989) (17)
- Irreversible alteration of opiate receptor function by a photoaffinity labelling reagent. (1975) (16)
- A peptide derived from an extracellular domain selectively inhibits receptor internalization: target sequences on insulin and insulin-like growth factor 1 receptors. (1997) (16)
- AMOUNTS AND TURNOVER RATES OF BRAIN PROTEINS IN MORPHINE‐TOLERANT MICE (1971) (15)
- A pituitary endorphin with novel properties. (1979) (14)
- Opioid peptide identity and localization in hippocampus. (1982) (14)
- Conversion of Leumorphin (Dynorphin B‐29) to Dynorphin B and Dynorphin B‐14 by Thiol Protease Activity (1986) (14)
- Rapid purification of β-endorphin by high-performance liquid chromatography (1978) (14)
- Dynorphin immunoreactivity in pituitary. (1982) (14)
- On the role of chemotherapy in the treatment of heroin addiction. (1975) (13)
- Lethality of the morphinan isomers levorphanol and dextrorphan (1973) (13)
- 22. – FUTURE RESEARCH ON OPIOID PEPTIDES (ENDORPHINS): A PREVIEW (1977) (13)
- Properties and behavior of purified human plasma cholinesterase. I. Stability and thermal denaturation. (1951) (13)
- Activation of erythropoietin receptor through a novel extracellular binding site. (2002) (13)
- Tolerance to opioid narcotics, II. Cellular tolerance to levorphanol in mouse brain. (1970) (12)
- Activation of Erythropoietin Receptor through a Novel Extracellular Binding Site. (2002) (12)
- A photochemical affinity-labelling reagent for the opiate receptor(s). (1972) (12)
- Interactions of narcotic antagonists with receptor sites. (1973) (12)
- Some thoughts about endogenous opioids and addiction. (1983) (12)
- Pharmacological and immunological characterization of the LEU5 analogue of human β-endorphin (1979) (11)
- Cellular and metabolic tolerance to an opioid narcotic in mouse brain (1973) (11)
- Opioid and other peptides as inhibitors of leumorphin (dynorphin B-29) converting activity (1986) (11)
- A "Free Manometer" Technique for Use with the Warburg Apparatus (1949) (11)
- Antagonism by physostigmine of the “running fit” caused by levorphanol, a morphine congener, in mice (1969) (10)
- Caffeine dependence in schoolchildren (1997) (10)
- PITUITARY AND BRAIN OPIOID PEPTIDES (ENDORPHINS) * (1977) (10)
- Collaboration and responsibility. (1988) (9)
- Selectivity of dynorphin for kappa opioid receptors. (1982) (9)
- A "Free Manometer" Method of Using the Standard Warburg Apparatus. (1949) (8)
- Opiate Receptors and Their Endogenous Ligands (Endorphins) (1978) (8)
- Properties and behavior of purified human plasma cholinesterase. II. Inactivation by mercuric chloride. (1951) (7)
- Further studies on the nature and functions of pituitary endorphins. (1978) (6)
- A monoclonal antibody specific for a dynorphin precursor (1985) (6)
- 6-Acetylmorphine: a natural product present in mammalian brain. (1988) (6)
- Dextrorphan binds to opioid receptors in guinea-pig brain membranes and is an antagonist at opioid receptors in myenteric plexus. (1990) (5)
- Amino acid residues essential for biological activity of a peptide derived from a major histocompatibility complex class I antigen. (1993) (5)
- A preformed, ordered structure of a 25-residue peptide derived from a major histocompatibility complex class I antigen is required to affect insulin receptor function. (1991) (4)
- Studies on endorphin function in animals and man (1979) (4)
- Chimeric opioid peptides: tools for identifying opioid receptor types. (1990) (4)
- Opioid activity of a benzomorphan lacking an oxygen atom. (1978) (3)
- On the Physiologic Role of Endorphins (1978) (3)
- Inhibitors of purified human plasma cholinesterase. (1948) (3)
- The effects of morphine-like compounds on the light responses of the brine shrimp Artemia salina (2004) (3)
- Pituitary Endorphins: Recent Progress (1979) (2)
- Expression Cloning of cDNA Encoding a Putative Opioid Receptor (1993) (2)
- CHARACTERIZATION OF DYNORPHIN RECEPTOR SPECIFICITY IN THE GUINEA PIG ILEUM (1981) (2)
- Rapid purification of beta-endorphin by high-performance liquid chromatography. (1978) (2)
- 3 – PITUITARY ENDORPHINS: RECENT PROGRESS (1978) (1)
- Brain chemistry and the addictions. (1986) (1)
- Recent Studies on the Binding of Opiate Narcotics to Possible Receptor Sites (1973) (1)
- Molecular Aspects of Narcotic Addiction. (1973) (0)
- OBSCURE BRAIN PEPTIDE IS POTENT PAINKILLER (1980) (0)
- Dynorphin immunoreactivity in rat gastrointestinal tract (1983) (0)
- Radioimmunoassays for beta-endorphin: comparison of properties of two antisera. (1978) (0)
- 1036 – NONSPECIFIC PHOTOCHEMICAL ATTACHMENT OF OPIATES TO BRAIN TISSUE (1977) (0)
- Immunoreactive dynorphin in pituitary and brain ( endorphin / neuropeptide / radioimmunoassay ) (0)
- CHARACTERISTICS OF OPIOID PEPTIDES FROM BRAIN AND PITUITARY (1978) (0)
- CONTRASTING THE REINFORCING ACTIONS OF ACETALDEHYDE AND ETHANOL WITHIN THE VENTRAL TEGMENTAL AREA OF ALCOHOL-PREFERRING (P) RATS. (2004) (0)
- The mechanism of interaction of inhibitors with human plasma cholinesterase. (1948) (0)
- Replication and the scientific method. (1987) (0)
- Response : Drug Abuse Policy (1991) (0)
- "Soul-Searching" and China (1989) (0)
- (processing/neuropeptide/opioid/leumorphin/rimorphin/protease) (2016) (0)
- Opioid peptides (endorphins) in pituitary and brain A. Goldstein, Science, 193 (1976) 1081–1086 (1977) (0)
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