Axel Behrens
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Computer Science
Axel Behrens's Degrees
- Masters Computer Science Stanford University
- Bachelors Computer Science University of California, Berkeley
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Why Is Axel Behrens Influential?
(Suggest an Edit or Addition)According to Wikipedia, Axel Behrens is a German-British molecular biologist and an expert in cancer stem cell biology. He is the Scientific Director of the Cancer Research UK Convergence Science Centre in London, a senior group leader at the Institute of Cancer Research and a professor at Imperial College London.
Axel Behrens's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Replication stress links structural and numerical cancer chromosomal instability (2013) (697)
- Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation (1999) (687)
- c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration (2012) (602)
- The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration (2004) (472)
- c-Jun is a negative regulator of myelination (2008) (373)
- Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development (2005) (371)
- The Ubiquitin Ligase SCFFbw7 Antagonizes Apoptotic JNK Signaling (2004) (370)
- The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development (2000) (308)
- Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c‐jun in the liver (2002) (264)
- The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer (2012) (262)
- NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression (2011) (248)
- Specific pathophysiological functions of JNK isoforms in the brain (2005) (228)
- NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment (2012) (227)
- Integrin signalling regulates YAP and TAZ to control skin homeostasis (2016) (220)
- c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling (2012) (215)
- Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation (2000) (214)
- Role of the AP-1 transcription factor c-Jun in developing, adult and injured brain (2006) (199)
- Increased skeletal VEGF enhances β‐catenin activity and results in excessively ossified bones (2010) (188)
- Impact of genomic damage and ageing on stem cell function (2014) (176)
- ATM signalling and cancer (2014) (168)
- Absence of the prion protein homologue Doppel causes male sterility (2002) (167)
- FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation (2011) (159)
- YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling (2016) (158)
- Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun (2010) (156)
- JNK signalling modulates intestinal homeostasis and tumourigenesis in mice (2009) (152)
- JunB can substitute for Jun in mouse development and cell proliferation (2002) (151)
- Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease (2015) (138)
- c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex (2011) (132)
- ERK activation causes epilepsy by stimulating NMDA receptor activity (2007) (118)
- The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. (2014) (116)
- F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. (2010) (112)
- A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development (2017) (106)
- Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells (2014) (102)
- Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis (2019) (93)
- Small is not beautiful: antagonizing functions for the prion protein PrPC and its homologue Dpl (2002) (88)
- ATMIN defines an NBS1‐independent pathway of ATM signalling (2007) (85)
- Impaired intervertebral disc formation in the absence of Jun (2003) (75)
- Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression (2017) (74)
- CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth (2019) (68)
- Dual regulation of Fbw7 function and oncogenic transformation by Usp28. (2014) (67)
- Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate (2012) (66)
- Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel (2001) (66)
- The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling (2015) (65)
- The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer (2018) (65)
- Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours (2016) (64)
- The ATM Cofactor ATMIN Protects against Oxidative Stress and Accumulation of DNA Damage in the Aging Brain* (2010) (57)
- Fbw7 Repression by Hes5 Creates a Feedback Loop That Modulates Notch-Mediated Intestinal and Neural Stem Cell Fate Decisions (2013) (57)
- Usp28 counteracts Fbw7 in intestinal homeostasis and cancer. (2015) (53)
- Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity (2012) (53)
- 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells (2017) (50)
- Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines (2013) (50)
- Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer. (2012) (48)
- Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions (2004) (48)
- LUBAC determines chemotherapy resistance in squamous cell lung cancer (2019) (47)
- UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function (2014) (46)
- The F-box protein Fbw7 is required for cerebellar development. (2011) (44)
- Competition between NBS1 and ATMIN controls ATM signaling pathway choice. (2012) (41)
- ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma (2011) (40)
- Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation (2010) (38)
- Arginine methylation of the c‐Jun coactivator RACO‐1 is required for c‐Jun/AP‐1 activation (2013) (35)
- RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress (2015) (34)
- Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH (2020) (33)
- Tissue clearing to examine tumour complexity in three dimensions (2021) (29)
- Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans (2018) (29)
- Regulation of αβ/γδ T Cell Development by the Activator Protein 1 Transcription Factor c-Jun1 (2007) (28)
- Peripheral Facial Nerve Axotomy in Mice Causes Sprouting of Motor Axons Into Perineuronal Central White Matter: Time Course and Molecular Characterization (2009) (28)
- Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas (2021) (28)
- Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions (2020) (28)
- Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance. (2016) (27)
- ATMINistrating ATM signaling (2008) (27)
- DMAP1 is an essential regulator of ATM activity and function (2014) (25)
- ATMINistrating ATM signalling: regulation of ATM by ATMIN. (2008) (24)
- Integrin signalling regulates YAP and TAZ to control skin homeostasis (2016) (23)
- Regulation of alphabeta/gammadelta T cell development by the activator protein 1 transcription factor c-Jun. (2007) (22)
- FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development (2011) (21)
- USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma (2020) (18)
- MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma. (2019) (17)
- JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer (2021) (16)
- FLYWCH1, a Novel Suppressor of Nuclear β-Catenin, Regulates Migration and Morphology in Colorectal Cancer (2018) (16)
- METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability (2022) (16)
- Physiological and pathological functions of the prion protein homologue Dpl. (2003) (15)
- Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action (2007) (14)
- Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation (2016) (14)
- RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress (2016) (14)
- DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation (2015) (13)
- The deubiquitylase USP9X controls ribosomal stalling (2020) (13)
- WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis (2019) (12)
- Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 (2021) (12)
- USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer (2022) (12)
- MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis (2018) (12)
- Bag1-L Is a Phosphorylation-Dependent Coactivator of c-Jun during Neuronal Apoptosis (2010) (12)
- Paligenosis: prepare to regenerate! (2018) (11)
- High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer (2021) (10)
- Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias (2021) (9)
- ATMIN is a tumor suppressor gene in lung adenocarcinoma. (2019) (9)
- Tissue architecture in tumor initiation and progression. (2022) (8)
- c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea123 (2016) (8)
- Fbw 7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c - (2010) (8)
- c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism (2019) (8)
- The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury (2007) (7)
- Prion proteins and infertility: insight from mouse models (2004) (6)
- Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into a , d , and b Cells (5)
- Regulation of / T Cell Development by the Activator Protein 1 Transcription Factor c-Jun (2007) (4)
- Perturbed hematopoiesis in mice lacking ATMIN. (2016) (4)
- Correction: The deubiquitylase USP9X controls ribosomal stalling (2021) (3)
- Peripheral Facial Nerve Axotomy in Mice Causes Sprouting of Motor Axons Into Perineuronal Central White Matter: Time Course and Molecular Characterization (2012) (3)
- TMOD-01. CMYC OVEREXPRESSION INDUCES CHOROID PLEXUS TUMOURS THROUGH MODULATION OF INFLAMMATORY PATHWAYS (2017) (3)
- Arginine methylation: Making its mark on AP-1 gene activation (2013) (3)
- TAZ Control Pancreatic Cancer Initiation in Mice by Direct Upregulation of JAK – STAT 3 Signaling (2016) (2)
- PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway (2021) (2)
- The Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity (2021) (2)
- An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment (2021) (2)
- SCHWANN CELL C-JUN REGULATES GLIAL SUPPORT FOR SURVIVAL OF PNS NEURONS AFTER INJURY (2009) (1)
- SCHWANN CELL C-JUN IS ESSENTIAL FOR SUCCESSFUL PERIPHERAL NERVE REGENERATION (2013) (1)
- A central role for c-Jun in regulating the differentiation of Schwann cells (2007) (1)
- Microenvironment and Immunology Vanilloid Receptor-1 Regulates Neurogenic In fl ammation in Colon and Protects Mice from Colon Cancer (2012) (1)
- SCHWANN CELL C-JUN IS ESSENTIAL FOR SUCCESSFUL NERVE REGENERATION (2013) (1)
- The Role of c‐Jun in Brain Function (2006) (1)
- Author response: USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma (2021) (0)
- Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism (2019) (0)
- Oxaliplatin Compromised CDK1 Activity Sensitizes BRCA-Proficient Cancers to PARP Inhibition in Oxaliplatin Resistance Gastric Cancer (2021) (0)
- NOVEL INTERACTIONS BETWEEN THE C-JUN AND NOTCH SIGNALLING PATHWAYS REGULATE THE SCHWANN CELL RESPONSE TO PERIPHERAL NERVE INJURY (2013) (0)
- Correction to: c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism (2019) (0)
- Role of c-Jun in Neonatal Hypoxic-Ischemic Brain Injury (2009) (0)
- Correction: Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans (2019) (0)
- HEMATOPOIESIS AND STEM CELLS Perturbed hematopoiesis in mice lacking ATMIN (2016) (0)
- Corrigendum: Replication stress links structural and numerical cancer chromosomal instability (2013) (0)
- Identification of ubiquitylated lysines on FBXW7 (2021) (0)
- Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas. (2023) (0)
- The role of transcription factor c-Jun in SOD1 G93A-mediated amyotrophic lateral sclerosis (2011) (0)
- Author response: Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation (2016) (0)
- sensitivity in rectum and distal colon and capsaicin in mouse large intestine: high abundance Localization of TRPV1 and contractile effect of (2012) (0)
- Abstract IA-07: Mechanisms of cellular heterogeneity in pancreatic cancer (2020) (0)
- Lack of adaptation to centriolar defects leads to p53-independent microcephaly in the absence of Cep135 (2020) (0)
- Procede d'identification de substances pour le traitement de troubles induits par la c-jun (1999) (0)
- deletion and small molecule inhibition destabilises c-MYC and elicits 1 regression of squamous cell lung carcinoma 2 3 (0)
- Perturbed Hematopoiesis In Mice Lacking ATMIN (an ATM co-Factor) (2013) (0)
- MDH1andMPP7RegulateAutophagy inPancreatic Ductal Adenocarcinoma (2019) (0)
- Title: Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice (2012) (0)
- Declined Presentation: Perturbed hematopoiesis in mice lacking ATMIN (an ATM co-factor) (2014) (0)
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