Bernard B. Brodie | Academic Influence

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Bernard B. Brodie's Published Works

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Published Works

A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. (1952) (2876)
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. (1973) (1667)
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. (1973) (1443)
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. (1973) (1152)
A simple, sensitive method for the assay of adenyl cyclase. (1968) (870)
Identification and assay of serotonin in brain. (1956) (843)
Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines. (1966) (729)
A CONCEPT FOR A ROLE OF SEROTONIN AND NOREPINEPHRINE AS CHEMICAL MEDIATORS IN THE BRAIN (1957) (602)
Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation. (1954) (536)
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. (1973) (480)
The gastric secretion of drugs: a pH partition hypothesis. (1957) (458)
The estimation of antipyrine in biological materials. (1949) (443)
On the mechanism of intestinal absorption of drugs. (1959) (422)
SOME PHYSICO‐CHEMICAL FACTORS IN DRUG ACTION (1957) (362)
Species, strain and sex differences in metabolism of hexobarbitone, amidopyrine, antipyrine and aniline (1958) (356)
Absorption of drugs from the rat small intestine. (1958) (355)
Possible mechanism of liver necrosis caused by aromatic organic compounds. (1971) (351)
Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma. (1967) (320)
Biochemical Mechanisms of Drug Toxicity (1974) (319)
The estimation of acetanilide and its metabolic products, aniline, N-acetyl p-aminophenol and p-amino-phenol, free and total conjugated, in biological fluids and tissues. (1948) (318)
APPLICATION OF STEADY STATE KINETICS TO THE SYNTHESIS RATE AND TURNOVER TIME OF SEROTONIN IN THE BRAIN OF NORMAL AND RESERPINE-TREATED RATS (1966) (318)
Serotonin release as a possible mechanism of reserpine action. (1955) (307)
The fate of aminopyrine (pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material. (1950) (285)
The physiological disposition and metabolic fate of hydrocortisone in man. (1955) (281)
The use of antipyrine in the measurement of total body water in man. (1949) (276)
Absorption of drugs from the stomach. I. The rat. (1957) (273)
The enzymatic metabolism of hexobarbital (evipal). (1955) (268)
PATHWAYS OF DRUG METABOLISM * , † (1956) (259)
THE IMPORTANCE OF DISSOCIATION CONSTANT AND LIPID-SOLUBILITY IN INFLUENCING THE PASSAGE OF DRUGS INTO THE CEREBROSPINAL FLUID (1960) (256)
Compulsive Sexual Activity Induced by p-Chlorophenylalanine in Normal and Pinealectomized Male Rats (1969) (254)
The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material. (1953) (253)
Interaction of reserpine, serotonin, and lysergic acid diethylamide in brain. (1955) (248)
The fate of antipyrine in man. (1950) (247)
Inability of newborn mice and guinea pigs to metabolize drugs (1959) (237)
The enzymatic reduction of chloramphenicol, p-nitrobenzoic acid and other aromatic nitro compounds in mammals. (1957) (217)
STORAGE, SYNTHESIS, AND METABOLISM OF MONOAMINES IN THE DEVELOPING BRAIN (1962) (213)
Serotonin as a mediator of reserpine action in brain. (1956) (213)
Evidence that serotonin has a role in brain function. (1955) (208)
Alcohol-Induced Triglyceride Deposition in Liver Through Derangement of Fat Transport (1961) (207)
THE FATE OF ACETOPHENETIDIN (PHENACETIN) IN MAN AND METHODS FOR THE ESTIMATION OF ACETOPHENETIDIN AND ITS METABOLITES IN BIOLOGICAL MATERIAL (1949) (205)
Biochemical and pharmacological studies of RO 1-9569 (tetrabenazine), a nonindole tranquilizing agent with reserpine-like effects. (1959) (200)
Assay of serotonin and related metabolites, enzymes, and drugs. (2006) (195)
The fate of pentobarbital in man and dog and a method for its estimation in biological material. (1953) (194)
Absorption of drugs from the stomach. II. The human. (1957) (194)
A spectrophotofluorometric study of compounds of biological interest. (1957) (187)
Ascorbic acid in aromatic hydroxylation. II. Products formed by reaction of substrates with ascorbic acid, ferrous ion, and oxygen. (1954) (178)
KINETICS OF PENETRATION OF DRUGS AND OTHER FOREIGN COMPOUNDS INTO CEREBROSPINAL FLUID AND BRAIN (1959) (174)
Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex. (1977) (171)
The physiological disposition and cardiac effects of procaine amide. (1951) (165)
Possible interrelationship between release of brain norepinephrine and serotonin by reserpine. (1957) (165)
The effects of inorganic ions on the storage and uptake of H3-norepinephrine by rat heart slices. (1969) (158)
Depot fat as source of increased liver triglycerides after ethanol. (1960) (158)
INTERACTION OF GUANETHIDINE WITH ADRENERGIC NEURONS. (1965) (158)
Role of sodium, potassium, ouabain and reserpine in uptake, storage and metabolism of biogenic amines in synaptosomes. (1968) (157)
The fate of acetanilide in man. (1948) (156)
Mechanism of the potentiating action of beta-diethylaminoethyl diphenylpropylacetate. (1954) (154)
ROLE OF BRAIN SEROTONIN IN RESERPINE ACTION (1957) (153)
Physiological disposition and fate of chlorpromazine and a method for its estimation in biological material. (1956) (147)
ON THE MECHANISM OF ANTIDEPRESSANT ACTION OF IMIPRAMINELIKE DRUGS (1962) (145)
The role of brain serotonin in the mechanism of the central action of reserpine. (1966) (143)
Inhibitory effects of beta-diethylaminoethyl diphenylpropylacetate on a variety of drug metabolic pathways in vitro. (1954) (142)
Norepinephrine Depletion as a Possible Mechanism of Action of Guanethidine a New Hypotensive Agent (1960) (141)
Relationship between the lipid solubility of drugs and their oxidation by liver microsomes. (1959) (141)
The direct determination of liver triglycerides. (1961) (140)
Beta‐Receptor Activity in Aorta: Variations with Age and Species (1970) (137)
Bromobenzene metabolism and hepatic necrosis. (1971) (136)
THE ACTION OF DESMETHYLIMIPRAMINE IN COUNTERACTING SEDATION AND CHOLINERGIC EFFECTS OF RESERPINE-LIKE DRUGS (1964) (135)
Drug metabolism as a cause of drug toxicity. (1973) (133)
Interrelationships of catecholamines with other endocrine systems. (1966) (132)
A chemical method for the determination of free choline in plasma. (1953) (132)
Enzymatic reduction of prontosil and other azo dyes. (1957) (130)
THE ESTIMATION OF QUININE IN HUMAN PLASMA WITH A NOTE ON THE ESTIMATION OF QUINIDINE (1943) (128)
Interaction of drugs with norepinephrine in the brain. (1959) (128)
Enzymatic pathway for the formation of cotinine, a major metabolite of nicotine in rabbit liver. (1960) (127)
THE DETERMINATION OF SALICYLIC ACID IN PLASMA (1944) (119)
Displacement of One Drug by Another from Carrier or Receptor Sites (1965) (117)
THE ESTIMATION OF BASIC ORGANIC COMPOUNDS AND A TECHNIQUE FOR THE APPRAISAL OF SPECIFICITY APPLICATION TO THE CINCHONA ALKALOIDS (1945) (116)
ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN DRUG‐INDUCED FATTY LIVER (1963) (116)
ANTICONVULSANT PROPERTIES OF MONOAMINE OXIDASE INHIBITORS (1959) (115)
Essential role of catecholamines in the mobilization of free fatty acids and glucose after exposure to cold. (1962) (115)
The physiological disposition of dicumarol in man. (1950) (111)
The physiological disposition and fate of meperidine (demerol) in man and a method for its estimation in plasma. (1955) (103)
Structural requirements for bretylium and guanethidine-like activity. (1962) (103)
Effect of iproniazid on brain levels of norepinephrine and serotonin. (1958) (101)
INTERACTION OF DRUGS WITH THE PITUITARY‐ADRENOCORTICAL SYSTEM IN THE PRODUCTION OF THE FATTY LIVER (1963) (100)
Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats. (1961) (100)
The Pharmacological Basis for the Rational Use of Atabrine in the Treatment of Malaria. (1944) (98)
Postoperative pain; its use in the comparative evaluation of analgesics. (1952) (97)
Nematode parasites of potatoes (1993) (96)
Effects of thyroid hormones on adenyl cyclase in adipose tissue and on free fatty acid mobilization. (1968) (96)
Concepts in Biochemical Pharmacology (1975) (96)
The Use of Procaine Amide in Cardiac Arrhythmias (1951) (95)
Brain amines and temperature regulation. (1968) (91)
The fate of procaine in man following its intravenous administration and methods for the estimation of procaine and diethylaminoethanol. (1948) (91)
The role of body fat in limiting the duration of action of thiopental. (1952) (90)
Vascular Smooth Muscle Reactivity in Normotensive and Hypertensive Rats (1969) (89)
Cholesterol in Serum (1958) (89)
Metabolic products of the cinchona alkaloids in human urine. (1951) (85)
The turnover of norepinephrine in thyrotoxic and nonthyrotoxic mice. (1963) (84)
Theophylline as a tool in studies of the role of cyclic adenosine 3',5'-monophosphate in hormone-induced lipolysis. (1966) (84)
Procaine Amide: A Review (1957) (84)
A spectrophotofluorometric study of organic compounds of pharmacological interest. (1957) (84)
Control of adipose tissue lipase activity by the sympathetic nervous system (1963) (82)
A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671. (1957) (81)
On the physiologic significance of monoamine oxidase in brain. (1957) (81)
Biochemical and pharmacological effects of the monoamine oxidase inhibitors, iproniazid, 1-phenyl-2-hydrazinopropane (JB 516) and 1-phenyl-3-hydrazinobutane (JB 835). (1960) (80)
The fate of thiopental in man and a method for its estimation in biological material. (1965) (80)
Role of sodium and potassium ions in storage of norepinephrine by sympathetic nerve endings. (1966) (80)
Evidence for a role of adenosine 3',5'-monophosphate in adipose tissue lipolysis. (1966) (79)
Part VI. Difficulties in extrapolating data on metabolism of drugs from animal to man (1962) (78)
The metabolic fate of phenylbutazone (butazolidin) in man. (1955) (77)
Potentiating Action of Chlorpromazine and Reserpine (1955) (76)
Application of steady-state kinetics to the uptake and decline of H3-NE in the rat heart. (1968) (76)
Turnover rates of norepinephrine in hearts of intact mice, rats and guinea pigs using tritiated norepinephrine (1963) (76)
Mechanism of biogenic amine transport. II. Relationship between sodium and the mechanism of ouabain blockade of the accumulation of serotonin and norepinephrine by synaptosomes. (1969) (75)
Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone. (1954) (74)
Association of behavoural effects of pargyline, a non-hydrazide mao inhibitor with increase in brain norepinephrine (1963) (74)
INTERACTION OF MONOAMINE OXIDASE INHIBITORS WITH PHYSIOLOGICAL AND BIOCHEMICAL MECHANISMS IN BRAIN (1959) (74)
Effects of decarboxylase inhibition on the biosynthesis of brain monoamines. (1962) (74)
Occurence of serotonin and catecholamines in brain and peripheral organs of various vertebrate classes (1963) (73)
On the mechanism of drug potentiation by iproniazid (2-isopropyl-1-isonicotinyl hydrazine). (1956) (73)
Behavioral and vegetative effects produced by dibutyryl cyclic AMP injected into different areas of the brain. (1970) (73)
On the mechanism of action of reserpine: effect of reserpine on capacity of tissues to bind serotonin. (1957) (72)
Mechanism of transport and storage of biogenic amines. 3. Effects of sodium and potassium on kinetics of 5-hydroxytryptamine and norepinephrine transport by rabbit synaptosomes. (1970) (72)
ON CURRENT STATUS OF SEROTONIN AS A BRAIN NEUROHORMONE AND IN ACTION OF RESERPINELIKE DRUGS (1962) (71)
Persistence of reserpine action after the disappearance of drug from brain: effect on serotonin. (1956) (71)
Physicochemical and biochemical aspects of pharmacology. (1967) (71)
The estimation of basic organic compounds in biological material; general principles. (1947) (71)
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons. (1973) (70)
Identification and physiological role of norepinephrine in adipose tissue (1961) (69)
The sympathetic nervous system as a homeostatic mechanism. I. Absolute need for sympathetic nervous function in body temperature maintenance of cold-exposed rats. (1967) (69)
The direct determination of phosphatidyl ethanolamine and phosphatidyl serine in plasma and red blood cells. (1953) (69)
On the mechanism of action of guanethidine and bretylium. (1965) (68)
Evidence that tranquilizing action of reserpine is associated with change in brain serotonin and not in brain norepinephrine. (1960) (67)
Total body water in man. (1950) (67)
Evidence for existence of alpha-adrenergic receptors in the mammalian trachea. (1970) (66)
Metabolism of drugs in subjects with Laennec's cirrhosis. (1959) (66)
Ascorbic acid in aromatic hydroxylation. III. Effect of ascorbic acid on hydroxylation of acetanilide, aniline and antipyrine in vivo. (1954) (66)
Metabolism of theophylline (1,3-dimethylxanthine) in man. (1952) (65)
Metabolic factors controlling duration of drug action (1962) (65)
Essential Role of Testosterone in the Sexual Stimulation induced by p-Chlorophenylalanine in Male Animals (1970) (64)
Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent. (1960) (64)
EVIDENCE FOR RELEASE OF BRAIN AMINES BY RESERPINE IN PRESENCE OF MONOAMINE OXIDASE INHIBITORS: IMPLICATION OF MONOAMINE OXIDASE IN NOREPINEPHRINE METABOLISM IN BRAIN (1960) (64)
The estimation of basic organic compounds in biological material; estimation by conversion to fluorescent compounds. (1947) (63)
Role for Ganglionic Norepinephrine in Sympathetic Synaptic Transmission (1961) (62)
Reserpine and guanethidine action on peripheral stores of catecholamines. (1962) (61)
Release of serotonin from blood platelets by reserpine in vitro. (1957) (60)
Enzymatic oxidation of pentobarbital and thiopental. (1957) (60)
THE USE OF BROMIDE AS A MEASURE OF EXTRACELLULAR FLUID (1939) (58)
BIOCHEMICAL PHARMACOLOGICAL CONSIDERATIONS OF PHENYLBUTAZONE AND ITS ANALOGUES (1960) (57)
On the mechanism of norepinephrine release by α-methyl-metatyrosine (1962) (56)
THE DISTRIBUTION OF IODIDE, THIOCYANATE, BROMIDE AND CHLORIDE IN THE CENTRAL NERVOUS SYSTEM AND SPINAL FLUID (1939) (55)
Release of blood platelet serotonin by reserpine and lack of effect on bleeding time. (1956) (54)
Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases. (1976) (54)
Evidence that blockade of adrenergic receptors causes overflow of norepinephrine in cats colon after nerve stimulation. (1967) (53)
Pharmacological consequences of the selective release of peripheral norepinephrine by syrosingopine (Su 3118). (1960) (52)
LSD-Like Effects Elicited by Reserpine in Rabbits Pretreated With Iproniazid.∗ (1957) (52)
Inhibition of drug metabolic pathways by the potentiating agent, 2, 4-dichloro-6-phenyl-phenoxyethyl diethylamine. (1955) (51)
Serotonin changes in platelets and brain induced by small daily doses of reserpine; lack of effect of depletion of platelet serotonin on hemostatic mechanisms. (1957) (51)
The estimation of basic organic compounds in biological material; estimation of fluorescent compounds. (1947) (51)
The estimation of basic organic compounds in biological material; estimation by salt formation with methyl orange. (1947) (49)
The physiological disposition of ethyl biscoumacetate (tromexan) in man and a method for its estimation in biological material. (1952) (49)
The passage of thiobarbiturates and their oxygen analogs into brain. (1958) (49)
On the mechanism of pituitary-adrenal stimulation by reserpine. (1962) (49)
Acute tolerance to thiopental. (1951) (49)
THE DISTRIBUTION OF ADMINISTERED BROMIDE IN COMPARISON WITH CHLORIDE AND ITS RELATION TO BODY FLUIDS (1939) (48)
Identification and Pharmacological Properties of a Major Metabolite of Chlorpromazine (1955) (48)
COMPARATIVE ACTION OF RESERPINE, TETRABENAZINE AND CHLORPROMAZINE ON CENTRAL PARASYMPATHETIC ACTIVITY: EFFECTS ON PUPILLARY SIZE AND LACRIMATION IN RABBIT AND ON SALIVATION IN DOG (1961) (46)
E. INTERACTIONS OF DRUGS WITH ADRENERGIC NEURONS (1966) (45)
Estimation of Dicumarol, 3, 31-Methylenebis (4-Hydroxycoumarin) in Biological Fluids.* (1949) (45)
Estimation of intracellular water in man. (1950) (44)
Lack of relationship between inhibition of monoamine oxidase and potentiation of hexobarbital hypnosis. (1960) (44)
Passage of lipid-insoluble substances from cerebrospinal fluid to blood. (1962) (43)
Selective labeling of histamine in rat gastric mucosa: application to measurement of turnover rate. (1968) (43)
Interaction between desipramine, tyramine, and amphetamine at adrenergic neurones (1968) (41)
Discharge of tritium-labeled guanethidine by sympathetic nerve stimulation as evidence that guanethidine is a false transmitter (1966) (41)
TOXICOLOGY AND THE BIOMEDICAL SCIENCES. (1965) (41)
Evidence that hyperthermia produced by d-amphetamine is caused by a peripheral action of the drug. (1969) (41)
Desmethylimipramine, a new type of antidepressant drug. (1961) (40)
Some current views on brain monoamines. (1962) (40)
Inhibition of norepinephrine synthesis in mouse brain by blockade of dopaminebeta-oxidase. (1962) (40)
The effects of desmethylimipramine on uptake of dl-norepinephrine-7-H3 in the heart. (1966) (39)
Bromobenzene-induced hepatic necrosis: species differences and protection by SKF 525-A. (1971) (38)
IMPLICATIONS OF UPTAKE AND STORAGE OF NOREPINEPHRINE BY SYMPATHETIC NERVE ENDINGS. (1963) (38)
The sympathetic nervous system as a homeostatic mechanism. II. Effect of adrenocortical hormones on body temperature maintenance of cold-exposed adrenalectomized rats. (1967) (37)
Conversion of transquilizers to antidepressants by removal of one N-methyl group. (1963) (36)
The transmission of meperidine across the human placenta. (1952) (36)
Principles and perspectives in drug bioavailability (1979) (34)
Is Reserpine Tranquilization Linked to Change in Brain Serotonin or Brain Norepinephrine? (1960) (34)
Kinetics of release of norepinephrine by tyramine. (1965) (34)
Drugs and enzymes (1965) (34)
THE ESTIMATION OF ATABRINE IN BIOLOGICAL FLUIDS AND TISSUES (1943) (33)
THE DISTRIBUTION OF ADMINISTERED IODIDE AND THIOCYANATE IN COMPARISON WITH CHLORIDE, AND THEIR RELATION TO BODY FLUIDS (1937) (33)
The biotransformation of ethyl biscoumacetate (tromexan) in man, rabbit and dog. (1953) (33)
The mechanism of serotonin and catecholamine uptake by platelets. (1959) (33)
Selective labeling and release of nonmast-cell histamine. (1966) (33)
ON THE SOURCE OF THE CEREBROSPINAL FLUID. THE DISTRIBUTION OF BROMIDE AND IODIDE THROUGHOUT THE CENTRAL NERVOUS SYSTEM (1940) (31)
The fate of dibenzyline in the body and the role of fat in its duration of action. (1954) (31)
Phenylbutazone metabolites: antirheumatic, sodium-retaining and uricosuric effects in man. (1958) (31)
On mechanisms of norepinephrine release by amphetamine and tyramine and tolerance to their effects. (1969) (30)
Mechanisms of drug absorption and of drug solution. (1972) (30)
PHARMACOLOGICAL CONSEQUENCES OF SELECTIVE DEPLETION OF CATECHOL AMINES BY ANTIHYPERTENSIVE AGENTS (1960) (29)
RESERPINE-INDUCED RELEASE OF DRUGS FROM SYMPATHETIC NERVE ENDINGS. (1964) (29)
Serotonin in brain: functional considerations. (1968) (29)
FORMATION, STORAGE AND METABOLISM OF SEROTONIN (5-HYDROXYTRYPTAMINE) AND CATECHOLAMINES IN LOWER VERTEBRATES (1964) (29)
DISAPPEARANCE OF VARIOUS DRUGS FROM THE CEREBROSPINAL FLUID (1960) (29)
The absence of blood-brain barrier from certain areas of the central nervous system. (1961) (28)
ACTH-hypersecretion induced by phenothiazine tranquilizers. (1963) (28)
The effect of norepinephrine and insulin on brown fat cell membrane potentials. (1970) (27)
48 On Mechanism of the antidepressant action of imipramine (1961) (27)
Biogenic Amines and Drug Action in the Nervous System of Various Vertebrate Classes (1964) (26)
On a Role for Serotonin and Norepinephrine as Chemical Mediators in the Central Autonomic Nervous System (1957) (26)
Use of N-Acetyl 4-Aminoantipyrine (NAAP)∗ in Measurement of Total Body Water (1951) (25)
THE ACTIONS OF RESERPINE, GUANETHIDINE AND METARAMINOL ON CARDIAC CATECHOLAMINE STORES. (1964) (25)
The passage of thiopental into brain. (1957) (25)
The effect on the pain threshold of N-acetyl p-aminophenol, a product derived in the body from acetanilide. (1948) (25)
STRUCTURE AND ANTIDEPRESSANT ACTIVITY OF IMIPRAMINE ANALOGUES. (1964) (24)
Dorsal root ganglion blockade during threshold segmental spinal anesthesia in man. (1954) (24)
THE PASSAGE OF BROMIDE, IODIDE AND THIOCYANATE INTO AND OUT OF THE CEREBROSPINAL FLUID (1940) (24)
The estimation of basic organic compounds in biological material; estimation by coupling with diazonium salts. (1947) (24)
SITES OF SENSORY BLOCKADE DURING SEGMENTAL SPINAL AND SEGMENTAL PERIDURAL ANESTHESIA IN MAN (1953) (23)
The determination of bromide in tissues and biological fluids. (1938) (23)
Relationship between pKa and Uricosuric Activity in Phenylbutazone Analogues (1958) (23)
CONCEPT OF THE NEUROCHEMICAL TRANSDUCER AS AN ORGANIZED MOLECULAR UNIT AT SYMPATHETIC NERVE ENDINGS. (1963) (23)
DRUG METABOLISM IN MAN: PAST, PRESENT, AND FUTURE (1971) (23)
NEUROCHEMICAL TRANSDUCER SYSTEMS. (1963) (22)
On the role of adenyl cyclase in the regulation of lipolysis in fasting. (1969) (22)
The fate of intrathecal procaine and the spinal fluid level required for surgical anesthesia. (1950) (22)
An interpretation of the action of psychotropic drugs. (1958) (22)
270 The effect of drugs on storage and release of serotonin and catecholamines in brain (1961) (22)
The physiologic role of the sympathetic nervous system in exercise. (1966) (21)
The physiological disposition and metabolic fate of cortisone in man. (1957) (21)
The physiological disposition and biotransformation of dibenamine and a method for its estimation in biological tissues. (1952) (21)
Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil) (1961) (21)
The estimation of basic organic compounds in biological material; estimation by ultraviolet spectrophotometry. (1947) (21)
Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous system (1955) (21)
Observations on G-25671, A Phenylbutazone Analogue (4-(phenylthioethyl) −1,2-diphenyl 3,5-pyrazolidinedione).∗ (1954) (21)
Uptake and release of 3-H-histamine in cat submaxillary gland. (1967) (20)
EFFECT OF 1-PHENYL-2-HYDRAZINOPROPANE, A POTENT MONOAMINE OXIDASE (MAO) INHIBITOR, ON BRAIN LEVELS OF NOREPINEPHRINE AND SEROTONIN (1958) (20)
Metabolites of Pamaquine in Urine.∗ (1950) (19)
Tricyclic Antidepressants: Evidence for an Intraneuronal Site of Action (1969) (19)
Interactions of drugs with adrenergic neurons. (1966) (19)
The clinical application of desmethylimipramine: A new type of antidepressant drug (1962) (19)
Structure and function of biologically active peptides : bradykinin, kallidin, and congeners (1963) (19)
SOME IDEAS ON THE MODE OF ACTION OF IMIPRAMINE-TYPE ANTIDEPRESSANTS (1965) (18)
Evidence that the loss of brain catecholamine stores due to blockade of storage does not cause sedation. (1962) (18)
UPTAKE AND RELEASE OF H3-HISTAMINE (1966) (18)
Evidence for the metabolism of bumetanide in man. (1975) (17)
Preliminary pharmacological and clinical results with desmethylimipramine (DMI) G 35020, a metabolite of imipramine (1961) (17)
Recent Views on Mechanisms for Lowering Sympathetic Tone (1963) (17)
[The fate of benzazoline (priscoline) in dog and man and a method for its estimation in biological material]. (1952) (17)
Effects of phenylbutazone on liver microsomal demethylase. (1970) (16)
Passage of Saccharides from Cerebrospinal Fluid to Blood (1961) (16)
Biochemical, physiological, and pharmacological aspects of serotonin. (1957) (16)
Dealkylation of N-Alkylamines by Model Systems (1958) (15)
Possible mechanisms of drug-induced tissue lesions. (1971) (15)
The appearance of procaine in the spinal fluid during peridural block in man. (1953) (15)
Influence of hypothermia on chlorpromazine-induced changes in brain amine levels. (1962) (14)
Concepts in Biochemical Pharmacology (1971) (14)
The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material. (1949) (14)
Physiological disposition and chemical fate of thiobarbiturates in the body. (1952) (13)
STRUCTURAL AND FUNCTIONAL DIVERSITY IN HEME MONOOXYGENASES (2004) (12)
Effect of a phenylbutazone analog (4-[phenylthioethyl]-1, 2-diphenyl 3, 5-pyrazolidinedione) on urate clearance and other discrete renal functions in gouty subjects; evaluation as uricosuric agent. (1956) (12)
Reduction by pretreatment with dibenamine of hepatotoxicity induced by carbon tetrachloride, thioacetamide or dimethylnitrosamine (1974) (12)
The Isolation and Characterization of a Metabolic Product of 3,3'-Carboxymethylenebis-(4-hydroxycoumarin) Ethyl Ester (Tromexan) from Human Urine (1953) (12)
The relationship of streptolysin S inhibitor to phospholipids in the serum of human beings and experimental animals. (1952) (12)
STUDIES ON DIETHYLAMINOETHANOL (1949) (12)
Observations on the fate of dromoran in the dog and its secretion into the gastric juice. (1955) (11)
PHYSIOLOGICAL DISPOSITION OF CERTAIN N–ALKYL THIOBARBITURATES (1955) (11)
Inhibition of 5-hydroxyindoleacetic acid transport from the brain by 2,4-dinitrophenol (1968) (11)
Cotinine: an Oxidation Product of Nicotine formed by Rabbit Liver (1959) (11)
A ROLE FOR NOREPINEPHRINE IN GANGLIONIC TRANSMISSION * (1961) (10)
Jumping activity induced by sodium 5-(1,3-dimethylbutyl)-5-ethyl barbiturate. I. The role of the sympathetic nervous system. (1970) (10)
The importance of dissociaton constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid. (1960) (10)
A differential action of reserpine on brain dopamine stores in rabbit. (1962) (10)
Quinoline and its transformation products found in urine. (1950) (10)
A Suggested Effect on Levels of Catecholamine in Brain produced by Small Doses of Reserpine (1960) (9)
Effect of phenoxybenzamine on the turnover rate of heart norepinephrine. (1969) (9)
Effects of enzyme induction of synthesis and catabolism of corticosterone in rats. Analysis by means of steady-state kinetics. (1971) (9)
Symposium on clinical drug evaluation and human pharmacology. VI. Difficulties in extrapolating data on metabolism of drugs from animal to man. (1962) (9)
The physiological disposition of procaine in man. (1948) (9)
Effect of phenylbutazone (butazolidin) on experimentally induced ocular inflammation. (1955) (9)
Apparent depletion of NE stores after repetitive stimulation of cat colon in presence of phenoxybenzamine. (1966) (8)
Effect of chlorpromazine and reserpine on the central actions of morphine in the cat. (1961) (8)
THE DETERMINATION OF THIOCYANATE IN TISSUES (1937) (8)
Some pharmacological consequences of species variation in rates of metabolism. (1967) (8)
THE DISTRIBUTION OF ADMINISTERED IODIDE AND THIOCYANATE IN COMPARISON WITH CHLORIDE IN PATHOLOGICAL TISSUES, AND THEIR RELATION TO BODY FLUIDS (1937) (8)
Theories on mechanism of action of psychotherapeutic drugs. (1961) (8)
Selective labeling of histamine in rat gastric mucosa. (1967) (7)
Serotonin storage mechanism and its interaction with reserpine (1958) (7)
THE USE OF PROCAINE AMIDE IN CARDIAC ARRHYTHMIAS (1952) (7)
Neurochemical pharmacology : a tribute to B.B. Brodie (1989) (6)
Analysis of basic organic compounds in biological tissues; coupling with diazonium salts. (1946) (6)
Increased lipolytic response to norepinephrine in isolated brown fat cells after sympathetic denervation. (1970) (6)
Intravenous anesthetics; new concepts. I. Experimental aspects. (1952) (5)
On the mechanism of norepinephrine release by alpha-methyl-metaty-rosine. (1962) (5)
An anticonvulsant effect of monoamine oxidase inhibitors (1959) (5)
A p-nitro analogue of phenylbutazone possessing potent antirheumatic, sodium retaining and uricosuric properties. (1959) (5)
EFFECT OF SYMPATHOMIMETIC AMINES ON DURATION OF PROCAINE SPINAL ANESTHESIA (1951) (5)
Interaction of non-steroidal antiinflammatory agents with corticosterone binding to plasma proteins in the rat. (1969) (5)
The control of prothrombin activity with tromexan therapy. (1953) (5)
Is man a unique animal in response to drugs? (1969) (5)
The methyl ether of methyl reserpate; a prototype of reversible short-acting tranquilizing agents. (1961) (5)
Effect of adrenalectomy and complete blockade of adrenergic function on mortality from histamine, endotoxin, formalin and tourniquet stress in rats. (1970) (5)
Differentiation of mechanisms of the antilipolytic actions produced by alpha and beta adrenergic blocking agents. (1969) (4)
Lack of Effect of Sodium Phenosulfazole (Darvisul) on Certain Experimental Virus Infections.* (1949) (4)
Fate of procaine in man and properties of its metabolite diethylaminoethanol. (1950) (4)
The estimation of 4'-carboxyphenylmethane sulfonanilide (caronamide) in biological fluids. (1947) (4)
EVIDENCE THAT CHLORPROMAZINE EXERTS A GENERALIZED CENTRAL SYMPATHOLYTIC ACTION (1957) (4)
Rapid biosynthesis of brain serotonin before and after reserpine administration (2004) (4)
Studies on the pharmacologic properties of procaine and diethyl-amino-ethanol. (1950) (4)
Bioavailability of Drugs: Conference, Washington, D.C., November 1971: Proceedings (1972) (4)
Association between reserpine syndrome and blockade of brain serotonin storage processes. (1962) (4)
THE ROLE OF AUTONOMIC NERVOUS FUNCTION IN MAMMALIAN THERMOREGULATION (1964) (4)
On the Reported Inhibition of Monoamine Oxidase by an Agent with Sedative Properties (1960) (4)
Reduction by pretreatment with dibenamine of hepatotoxicity induced by carbon tetrachloride, thioacetamide or dimethylnitrosamine. (1975) (4)
Cinchona alkaloids; metabolic products in human urine. (1946) (3)
Analysis of basic organic compounds in biological tissues; isolation prior to estimation. (1946) (3)
The Neurobiology of Slow Synaptic Transmission (2001) (3)
CHAPTER 11 – Enzyme Induction in Laboratory Animals and its Relevance to Food Additive Investigation (1970) (3)
Bioavailability of drugs : proceedings (1972) (3)
Basic Principles in Development of Methods for Drug Assay (1971) (2)
Some prospects in toxicology. (1969) (2)
Intravenous anesthesia; new concepts. II. Clinical aspects. (1952) (2)
Clinical application of studies of the physiologic disposition of thiopental. (1956) (2)
Contents, Vol. 8, 1963 (1963) (2)
Selective release of norepinephrine and serotonin by reserpine-like compounds. (1960) (2)
[Difficulties in transposing experimental results obtained with animals to man]. (1964) (2)
The renal excretion of 4'-carboxyphenylmethane sulfonanilide (caronamide). (1947) (2)
Interaction of Reserpine, Serotonin, and Lysergic Acid Diethylamide in Brain (1955) (2)
The toxicity of wax crayons in animals. (1948) (2)
Influence of adrenal cortical hormones on the norepinephrine-induced lipolysis. (1968) (2)
Mechanism of action (1972) (1)
Rate of norepinephrine synthesis after tyramine-induced depletion of norepinephrine in rat heart. (1972) (1)
Studies on diethylaminoethanol. II. Antiarrhythmic activity in two homologous alcohol series. (1950) (1)
The physiological disposition of acetophenetidin in man. (1948) (1)
THE MECHANISMS OF ADVERSE REACTIONS (1968) (1)
Serotonin in Relation to Brain Function: III. The Action of Psychotropic Drugs (A Biochemical and Physiological Interpretation). (1958) (1)
Minireviews of the neurosciences from Life sciences (Vols. 13, 14, 15) (1975) (1)
The mechanism of action of a new type of antidepressant drug which does not block monoamine oxidase. (1962) (1)
Analysis of basic organic compounds in biological tissues; estimation of fluorescent compounds. (1946) (1)
Evidence That the Rise in Temperature Produced by d -Amphetamine is Caused by a Peripheral Action of the Drug (1969) (1)
Evidence that the loss of brain catecholamine stores due to blockade of storage does not cause sedation. (1962) (1)
Analysis of basic organic compounds in biological tissues; ultraviolet spectrophotometry. (1946) (0)
Passage of Saccharides from Cerebrospinal Fluid to Blood. (1961) (0)
278 Metabolic factors controlling duration of drug action. introductory remarks (1961) (0)
[Concept of the neurochemical "transducer" and its molecular organization at the level of sympathetic endings]. (1964) (0)
Contents, Vol. 1, 1968 (1968) (0)
Contents, Vol. 7, 1972 (1972) (0)
Compound Index / Subject Index (1978) (0)
1098 – STUDIES ON THE COVALENT BINDING OF HEPATOTOXINS AND HEPATOCARCINOGENS TO LIVER MACROMOLECULES (1977) (0)
Idiosyncrasy and Intolerance (2008) (0)
PHYSIOLOGIC DISPOSITION ANI ) FATE OF PROCAINE AMIDE (0)
Three steroid saponins from japanese Dioscoreaceae plants, dioscin, gracillin and kikuba-saponin were proved to have branched-chain oligosaccharide moieties, and as- (2010) (0)
Research Achievement Awards (1972) (0)
Drug Metabolism—Subcellular Mechanisms (2008) (0)
Book Reviews / Instructions to Authors (1972) (0)
Evolution of nervous control from primitive organisms to man : a symposium organized by the Section on Medical Sciences of the American Association for the Advancement of Science and presented at the New York meeting on December 29-30, 1956 (1959) (0)
CURRENT LITERATURE Evidence that tranquilising action of reserpine is associated with change in brain serotonin and not in brain epinephrine (2014) (0)
Autonomic nervous system and adipose tissue (2011) (0)
Introduction to Chemical Pharmacology R. B. Barlow. New York, John Wiley and Sons, Inc., 1955, 343 pp. + xiv, $6.25 (1957) (0)
Effect of Iproniazid on Brain Levels of Norepinephrine and Serotonin (1958) (0)
The fate of acetanilide in the body. (1947) (0)
INTRODUCTION (1963) (0)
[Corneal anesthesia. Action of serotonin and histamine]. (1960) (0)
Analysis of basic organic compounds in biological tissues; salt formation with methyl orange. (1946) (0)
552 Phylogenetic origin of detoxication mechanisms (1961) (0)
NEUROCHEMICAL TRANSDUCER IS A STEP TOWARD PREDICTING DRUG ACTION. (1965) (0)
Subject Index Vol. 2, 1968 (1968) (0)
Effect of some N N-disubstituted dithiocarbamates on catecholamines level in rat brain (1969) (0)
[Research on the mechanism of reserpine action on the hypophysis]. (1961) (0)
Subject Index Vol. 7, 1972 (1972) (0)
599 – CONTROL OF DRUG-INDUCED ENZYMES BY A CYCLIC AMP-DEPENDENT MECHANISM (1977) (0)
Analysis of basic organic compounds in biological tissues; conversion to fluorescent compounds. (1946) (0)
Studies on the covalent binding of hepato toxins and hepato carcinogens to liver macro molecules (1977) (0)
Nixon on Science: Policy Paper Emphasizes Basic Research; Calls for Special Institutes. (1960) (0)
METABOLISM OF THIOPENTAL (1958) (0)
Evidence That Serotonin Has a Role in Brain Function (1955) (0)
The effect of drugs on the excretion of Theiler's virus (TO) by mice. (1952) (0)
Psychotropic Drugs . S. Garattini and V. Ghetti, Eds. Elsevier, Amsterdam, 1957 (order from Van Nostrand, Princeton, N.J.). 606 pp. Illus. $19.50. (1958) (0)
Title Page / Contents / Dedication / Preface (1979) (0)
Contents to Volume 47 (1996) (0)
Jumping Activity Induced by Sodium 5-(l,3-Dymethylbutyl)-5-Ethyl Barbiturate II. The Effects of Age Difference (1970) (0)
[Not Available]. (1947) (0)

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