Brendan J. R. Whittle
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Chemistry
Brendan J. R. Whittle's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Brendan J. R. Whittle Influential?
(Suggest an Edit or Addition)Brendan J. R. Whittle's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- 1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo* (1997) (837)
- Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. (1989) (557)
- Nitric oxide synthase activity in ulcerative colitis and Crohn's disease (1993) (469)
- Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa (1980) (397)
- Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat (1990) (384)
- Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species. (1978) (337)
- Temporal Relationship Between Cyclooxygenase Inhibition, as Measured by Prostacyclin Biosynthesis, and the Gastrointestinal Damage Induced by Indomethacin in the Rat (1981) (310)
- The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat (1993) (305)
- The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation. (1989) (256)
- Potent ulcerogenic actions of platelet-activating factor on the stomach (1986) (234)
- Nitric oxide synthase induction and intestinal epithelial cell viability in rats. (1993) (214)
- Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. (1981) (212)
- Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells. (1993) (201)
- Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa. (1983) (177)
- Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. (1987) (176)
- Gastrointestinal effects of nonsteroidal anti‐inflammatory drugs (2003) (166)
- Role of mucus in the repair of gastric epithelial damage in the rat. Inhibition of epithelial recovery by mucolytic agents. (1986) (161)
- Nitric oxide donors increase mucus gel thickness in rat stomach. (1992) (156)
- Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro. (1978) (150)
- Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa (1981) (150)
- Endogenous nitric oxide as a mediator of gastric mucosal vasodilatation during acid secretion. (1992) (146)
- Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. (1992) (145)
- Neuronal and endothelium‐derived mediators in the modulation of the gastric microcirculation: integrity in the balance (1993) (145)
- Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. (1995) (140)
- Gastric vasoconstrictor actions of leukotriene C4, PGF2 alpha, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo. (1985) (135)
- Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat. (1990) (129)
- Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin (1995) (121)
- Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat (1993) (121)
- Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. (2012) (118)
- Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo. (1992) (117)
- Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation. (1980) (115)
- Pharmacological interactions between prostacyclin and thromboxanes. (1983) (114)
- Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors. (2004) (112)
- Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase‐3β (2006) (107)
- Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat. (2005) (105)
- Association of microvascular leakage with induction of nitric oxide synthase: effects of nitric oxide synthase inhibitors in various organs. (1995) (105)
- Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture. (1988) (103)
- The modulation of IL-6 and TNF-α release by nitric oxide following stimulation of J774 cells with LPS and IFN-γ (1995) (97)
- Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins. (1976) (95)
- Morphine potentiation of ethanol-induced gastric mucosal damage in the rat. Role of local sensory afferent neurons. (1990) (84)
- Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. (1983) (77)
- The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis. (2008) (77)
- Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon. (1997) (77)
- Nitric oxide as a factor in inflammation (1999) (77)
- Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors (2000) (77)
- Role of prostanoids in the protective actions of BW755C on the gastric mucosa. (1985) (75)
- Nitric oxide synthase activity, viability and cyclic GMP levels in rat colonic epithelial cells: effect of endotoxin challenge. (1994) (70)
- Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. (1986) (69)
- Evaluation of the protection of rat gastric mucosa by a prostaglandin analogue using cellular enzyme marker and histologic techniques. (1985) (68)
- Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats. (1997) (65)
- COX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitors (2000) (64)
- Localization of constitutive isoforms of nitric oxide synthase in the gastric glandular mucosa of the rat (1996) (62)
- Nitric oxide mediates rat mucosal vasodilatation induced by intragastric capsaicin. (1992) (62)
- Nitric oxide: The elusive mediator of the hyperdynamic circulation of cirrhosis? (1992) (60)
- Effects of prostacyclin and a stable analogue, 6β-PGI1, on gastric acid secretion, mucosal blood flow, and blood pressure in conscious dogs (1979) (59)
- Nitric oxide--a mediator of inflammation or mucosal defence. (1997) (58)
- Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. (1986) (58)
- Involvement of nitric oxide and prostaglandins in gastric mucosal hyperemia of portal‐hypertensive anesthetized rats (1993) (57)
- Inhibition of gastric acid secretion by stress: a protective reflex mediated by cerebral nitric oxide. (1996) (52)
- Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. (1986) (52)
- PROSTAGLANDIN SYNTHETASE INHIBITORS (1979) (51)
- A biochemical basis for the gastrointestinal toxicity of non-steroid antirheumatoid drugs. (1984) (50)
- The use of stable prostaglandins to investigate prostacyclin (PGI2)-binding sites and PGI2-sensitive adenylate cyclase in human platelet membranes. (1984) (49)
- The role of nitric oxide and platelet-activating factor in the inhibition by endotoxin of pentagastrin-stimulated gastric acid secretion. (1992) (48)
- The nitric oxide donor, S-nitroso-N-acetyl-penicillamine, inhibits secretory activity in rat isolated parietal cells. (1993) (48)
- Biosynthesis and Role of the Endothelium‐Derived Vasodilator, Nitric Oxide, in the Gastric Mucosa (1992) (47)
- Role of mucus in the repair of gastric epithelial damage in the rat (1986) (46)
- Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat. (1989) (46)
- Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase (2008) (45)
- Direct cytotoxic effect of oxygen radicals on the gastric mucosa. (1989) (44)
- Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat. (2007) (44)
- Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs. (2001) (43)
- Modulation of human colonic arachidonic acid metabolism by sulfasalazine (1985) (43)
- Profile of gastrointestinal damage induced by platelet-activating factor. (1986) (42)
- Gastric vascular actions of prostanoids and the dual effect of arachidonic acid. (1982) (39)
- The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5‐Lipoxygenase on Anaphylactic and Inflammatory Responses (1988) (38)
- Lipopolysaccharide induces Ca2+-independent nitric oxide synthase activity in rat gastric mucosal cells (1994) (37)
- Effects of inhibitors of arachidonic acid metabolism on Paf‐induced gastric mucosal necrosis and haemoconcentration (1986) (37)
- Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco‐2: influence of cell differentiation (1999) (37)
- Cytotoxicity associated with induction of nitric oxide synthase in rat duodenal epithelial cells in vivo by lipopolysaccharide of Helicobacter pylori: inhibition by superoxide dismutase (2000) (35)
- The modulation of IL-6 and TNF-alpha release by nitric oxide following stimulation of J774 cells with LPS and IFN-gamma. (1995) (35)
- Platelet actions of stable carbocyclic analogues of prostacyclin. (1985) (35)
- Induction of nitric oxide synthase in vivo and cell injury in rat duodenal epithelium by a water soluble extract of Helicobacter pylori (1998) (35)
- Nitric oxide donors preferentially inhibit neuronally mediated rat gastric acid secretion. (1994) (34)
- Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents. (1981) (34)
- Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea‐pigs (1987) (34)
- Stimulation by carbachol of mucus gel thickness in rat stomach involves nitric oxide. (1994) (33)
- The role of extracellular mucus as a protective cap over gastric mucosal damage. (1986) (30)
- Nitric oxide in physiology and pathology (1995) (29)
- Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C. (1992) (29)
- Hemostatic mechanisms, independent of platelet aggregation, arrest gastric mucosal bleeding. (1986) (29)
- Potentiation of cytokine induced iNOS expression in the human intestinal epithelial cell line, DLD-1, by cyclic AMP (1999) (29)
- The endothelin explosion. A pathophysiological reality or a biological curiosity? (1990) (28)
- Cardiopulmonary and Gastric Ulcerogenic Actions of Endothelin‐1 in the Guinea Pig and Rat (1989) (27)
- Gastrointestinal plasma leakage in endotoxic shock. Inhibition by prostaglandin E2 and by a platelet-activating factor antagonist. (1987) (27)
- Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate. (1985) (27)
- Modulation by nitric oxide of spontaneous motility of the rat isolated duodenum: role of tachykinins (1996) (27)
- Nitric oxide mediates the inhibition by interleukin‐1β of pentagastrin‐stimulated rat gastric acid secretion (1993) (27)
- Helicobacter pylori lipopolysaccharide provokes iNOS-mediated acute systemic microvascular inflammatory responses in rat cardiac, hepatic, renal and pulmonary tissues (2001) (26)
- Inhibition by 16,16-dimethyl PGE2 of ethanol-induced gastric mucosal damage and leukotriene B4 and C4 formation. (1988) (26)
- Close-arterial administration of the thromboxane mimetic U-46619 induces damage to the rat gastric mucosa. (1988) (26)
- Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat. (2003) (26)
- Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs. (2004) (25)
- Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF. (1990) (25)
- Prostaglandin protection of rat colonic mucosa from damage induced by ethanol (1985) (25)
- Nitric oxide and sensory afferent neurones modulate the protective effects of low-dose endotoxin on rat gastric mucosal damage. (1995) (25)
- Use of the rabbit transverse stomach-strip to identify and assay prostacyclin, PGA2, PGD2 and other prostaglandins. (1979) (25)
- Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. (1989) (25)
- Site-specific lesion formation, inflammation and inducible nitric oxide synthase expression by indomethacin in the rat intestine. (2000) (25)
- Acceleration of recovery of gastric epithelial integrity by 16,16‐dimethyl prostaglandin E2 (1985) (24)
- Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins. (2013) (24)
- Prostacyclin analogues inhibit canine parietal cell activity and cyclic AMP formation. (1981) (23)
- The relative activity of prostacyclin (PGI2) and a stable analogue 6β‐PGI1 on the gastrointestinal and cardiovascular systems (1978) (23)
- Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. (2003) (23)
- Nitric oxide-modulating agents for gastrointestinal disorders (2005) (23)
- Relative potency of prostacyclin, prostaglandin E1 and D2 as inhibitors of platelet aggregation in several species [proceedings]. (1977) (22)
- Antithrombotic assessment and clinical potential of prostacyclin analogues. (1984) (22)
- New light on the anti-colitic actions of therapeutic aminosalicylates: the role of heme oxygenase. (2010) (22)
- THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E2 AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro (1981) (22)
- Advances In Drug Therapy Of Gastrointestinal Ulceration (1989) (22)
- Constitutive nitric oxide modulates the injurious actions of vasopressin on rat intestinal microcirculation in acute endotoxaemia. (1994) (21)
- Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. (1985) (19)
- Stimulation of gastric alkaline secretion by stable prostacyclin analogues in rat and dog. (1984) (19)
- Interaction between prostaglandins and cyclic AMP in the gastric mucosa. (1981) (19)
- Immediate anaphylactic bronchoconstriction induces airway hyperreactivity in anaesthetized guinea‐pigs (1988) (18)
- Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells (2018) (18)
- Colonic microvascular integrity in acute endotoxaemia: interactions between constitutive nitric oxide and 5-lipoxygenase products. (1995) (17)
- Lipopolysaccharide induces Ca(2+)-independent nitric oxide synthase activity in rat gastric mucosal cells. (1994) (17)
- Failure of prostaglandin E2 and its 16,16‐dimethyl analogue to prevent the gastric mucosal damage induced by Paf (1987) (16)
- Induction of nitric oxide synthase in rat intestine and its association with tissue injury (2005) (16)
- Nitric oxide synthase and arginase in cells isolated from the rat gastric mucosa. (1997) (16)
- Involvement of peroxynitrite in the lipid peroxidation induced by nitric oxide in rat gastric mucosa (1996) (15)
- Indomethacin potentiates endotoxin‐induced blood flow reduction and histological injury in rat gastric mucosa (1988) (15)
- British Journal of Clinical Pharmacology review series. Clinical research methods in gastroenterology. (2003) (15)
- Prostacyclin-sensitive adenylate cyclase in cultured myocytes: differences between rabbit aorta and mesenteric artery. (1984) (14)
- Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties. (1996) (14)
- Some actions of prostacyclin (PGI2) on the cardiovascular system and the gastric microcirculation. (1978) (14)
- Ulceration induced by an endoperoxide analog and by indomethacin in the canine stomach. (1983) (14)
- Helicobacter pylori lipopolysaccharide-provoked injury to rat gastroduodenal microvasculature involves inducible nitric oxide synthase. (2001) (14)
- Biological Activities of Some Metabolites and Analogues of Prostacyclin (1981) (14)
- New dogmas or old? (2003) (13)
- The differential response of a novel bioassay tissue, the rabbit transverse stomach-strip, to prostacyclin (PGI2) and other prostaglandins [proceedings]. (1977) (13)
- The cardiovascular and platelet actions of 9β‐methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey (1985) (12)
- Modulation by prostanoids of the release of inflammatory mediators from mast cells: involvement in mucosal protection? (1993) (12)
- Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats. (1998) (12)
- Nitric oxide and the gut injury induced by non-steroidal anti-inflammatory drugs (2004) (11)
- Nitric oxide in physiology and pathology (2004) (11)
- Assessment of anticolitic drugs in the trinitrobenzene sulfonic acid (TNBS) rat model of inflammatory bowel disease. (2003) (11)
- Involvement of endogenous nitric oxide in the inhibition by endotoxin and interleukin‐1β of gastric acid secretion (1994) (10)
- Biological actions of prostacyclin and its pharmacological use in platelet studies. (1985) (9)
- Gastric Venous Prostaglandin Concentrations during Basal and Stimulated Acid Secretion in Dog (1982) (8)
- Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1 (2017) (8)
- Nitric oxide mediates the inhibition by interleukin-1 beta of pentagastrin-stimulated rat gastric acid secretion. (1993) (8)
- Synthesis and platelet aggregation inhibiting activity of 1′-carboxyl modified hydantoin prostaglandin analogues (1989) (8)
- Nitric oxide and the gut injury induced by non-steroidal anti-in ammatory drugs (8)
- Endogenous nitric oxide in the maintenance of rat microvascular integrity against widespread plasma leakage following abdominal laparotomy (1999) (8)
- The role of leukotrienes in the pathogenesis of gastric ulceration. (1988) (7)
- Detrimental effects of oestradiol on cysteamine-induced gastroduodenal ulceration in the female rat (1999) (7)
- GW273629 is a highly selective, short-acting iNOS (NOS-2) inhibitor both in vitro and in vivo: beneficial effects in endotoxin shock (2000) (7)
- Nitric oxide modulates the gastrointestinal plasma extravasation following intraabdominal surgical manipulation in rats. (1999) (6)
- [Role of nitric oxide in maintaining the mucosal integrity and in inflammatory gastrointestinal diseases]. (1996) (6)
- Formation of prostacyclin and its product 6-oxo-PGF1alpha by the gastric mucosa of several species [proceedings]. (1978) (6)
- Increase In Gastric Intramucosal Hydrogen Ion Concentration Following Endotoxin Challenge In The Rat And The Actions Of Nitric Oxide Synthase Inhibitors (2001) (6)
- Biosynthesis of endogenous arachidonate products involved in gastric damage and protection (1984) (6)
- Gastric antisecretory and cardiovascular actions of a stable 16-phenoxy prostacyclin analog in the dog. (1980) (6)
- Gastrointestinal damage induced by platelet-activating factor (1988) (5)
- Endogenous bacteria-triggered inducible nitric oxide synthase activation protects the ovariectomized rat stomach (2001) (5)
- Inhibition of inducible nitric oxide synthase (iNOS) and induction of heme oxygenase-1 by bismuth preparations in human intestinal epithelial cells (2000) (5)
- Effects of prostaglandin E2 methyl analogues on the anti‐inflammatory and gastric erosive activity of indomethacin (1976) (5)
- Laboratory methods for studying the role of eicosanoids in inflammatory bowel disease (1988) (5)
- Assessment of the actions of prostanoids in the protection and repair of the gastric mucosa. (1986) (5)
- Ep2 Receptors Play A Key Role In Mediating The Anti-Proliferative Activity Of Treprostinil In Smooth Muscle Cells Derived From The Lungs Of Pulmonary Hypertensive Patients (2015) (4)
- Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension. (2019) (4)
- Characterisation of nitric oxide synthase activity in the rat colonic mucosa and muscle after endotoxin and in a model of colitis (1994) (4)
- Aminoguanidine promotes vasoconstriction and leukocyte adherence in rat mesentery through inhibition of constitutive nitric oxide synthase (1995) (4)
- Attenuation of Helicobacter pylori endotoxin-provoked rat intestinal inflammation by selective inhibition of the inducible nitric oxide synthase (2001) (4)
- The Journal of Rheumatology duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. Lymphocytic infiltration and expression of inducible nitric oxide synthase in human (2003) (4)
- The Therapeutic and Toxic Effects of Anti-Inflammatory Drugs Which Interfere with Arachidonic Acid Metabolism (1980) (4)
- Synthesis and Inhibitory Activity on Platelet Aggregation of 13′‐Aza and Other ω‐Chain Modified BW245C Analogues (1994) (4)
- Bradykinin stimulates PGE2 release in cell fractions isolated from the rat gastric mucosa via a B1 receptor. (1992) (4)
- Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat (2005) (4)
- Effects of prostacyclin and a stable analogue, 6-beta-PGI1, on gastric acid secretion, mucosal blood flow, and blood pressure in conscious dogs. (1979) (4)
- Endotoxin can decrease isolated rat parotid acinar cell amylase secretion in a nitric oxide-independent manner. (2005) (4)
- Beneficial effect of P54, A novel curcumin preparation in Tnbs-induced colitis in rats (2001) (3)
- Nitric oxide in vascular, intestinal and neuronal tissue: Interactions in the gut (1993) (3)
- Involvement of neuronal processes and nitric oxide in the inhibition by endotoxin of pentagastrin-stimulated sastric acid secretion (1994) (3)
- Gastric effects of PAF. (1989) (3)
- Pharmacological approach to the prevention of non-steroidal anti-inflammatory drug-induced gastropathy. (1999) (3)
- New targets for anti-ulcer drugs. (1988) (2)
- Pharmacological manipulation of vasoactive mediators in gastric damage and protection (1990) (2)
- Some characteristics of the gastric antisecretory actions of prostaglandins in mammalian perfused whole-stomachs in vitro [proceedings]. (1979) (2)
- Prostacyclin and its analogues for the therapy of thromboembolic disorders. (1984) (2)
- Metabolism of arginine to citrulline by rat gastric mucosal cells. (1996) (2)
- Gastric mucosal nitric oxide synthase activity: inhibition by phosphorylation, arginine analogues and trifluoperazine. (1994) (2)
- Inflammatory and protective mediators in experimental intestinal inflammation (1991) (2)
- Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future (2003) (2)
- Interactions of pro-inflammatory and vasoactive mediators with nitric oxide in the regulation of rat vascular permeability during laparotomy. (2000) (2)
- Heme oxygenase-1 (HO-l) induction in human intestinal epithelial cells by sulphasalazine and 5-aminosalicylic acid: A potential therapeutic mechanism (2000) (2)
- Rapid induction of the antioxidant, heme oxygenase-1 (HO-1) in human intestinal epithelial cells: Interaction with glutathione levels (2001) (2)
- Safer non-steroidal anti-inflammatory drugs: are cyclo-oxygenase inhibitors or nitric oxide non-steroidal anti-inflammatory drugs the grand finale? (2002) (2)
- Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs (2004) (1)
- A new era for gastrointestinal research — novel therapeutic targets for drug development (2004) (1)
- Involvement of the Eicosanoids, Thromboxane A 2 and Leukotriene C 4 in Gastric Mucosal Damage (1988) (1)
- 5-amino salicylic acid induced depletion of glutathione protects the colon against trinitrobenzene sulphonic acid injury through heme oxygenase-1 enzyme expression (2006) (1)
- Effects of prostacyclin (PGI2), PGI1 and 6-oxo-PGF1alpha on the rat gastric mucosa [proceedings]. (1978) (1)
- Role of Eicosanoids in the Pathogenesis of Inflammatory Bowel Diseases (1985) (1)
- 5-amino salicylic acid protects the colon against trinitrobenzene sulphonic acid injury through hemoxigenase-1 enzyme induction (2005) (1)
- Synthesis and Platelet Aggregation Inhibiting Activity of Acid Side‐chain Modified Hydantoin Prostaglandin Analogues (1993) (1)
- Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat (2005) (1)
- Role of glutathione in the induction of hemoxygenase-1 enzyme in intestinal epithelial cells (2005) (1)
- Inhibition of gastric motility changes following PAF-acether and endotoxin by L-652, 731 (1988) (1)
- Pharmacokinetics and pre-clinical efficacy of ralinepag (APD811) in humans and rats (2017) (1)
- Activity of prostacyclin, a stable analogue, 6 beta-PGI1 and 6-oxo-PGF1 alpha on canine isolated parietal cells [proceedings]. (1979) (1)
- Potentiation of cytokine-induced nitric oxide synthase activity of cyclic AMP derivatives in DLD-1 human intestinal epithelial cells (1998) (0)
- Modulators of Inducible Nitric Oxide Synthase: Potential Drugs for the Therapy of Gut Inflammation? (2002) (0)
- Actions of Selective and Non-selective Nitric Oxide Synthase Inhibitors on Multiple-Organ Microvacular Injury Provoked by Lipopolysaccharide (1999) (0)
- Prostacyclin inhibition and ulcerogenesis (1981) (0)
- Widespread intestinal vascular leakage accompanies inos expression following multiple doses of indomethacin in the rat (2000) (0)
- Interaction between PAF-acether and thromboxane in endotoxin-induced intestinal damage (1988) (0)
- Inhibition of inducible nitric oxide synthase (iNOS) by bismuth preparations and sulphasalasine in human intestinal epithelial cells (2000) (0)
- Early phase microvascular interactions in rat jejunum between nitric oxide and vasopressin following indomethacin administration (1998) (0)
- Synthesis and Platelet Aggregation Inhibiting Activity of 1′-Carboxyl Modified Hydantoin Prostaglandin Analogues. (1990) (0)
- Gastric mucosal damageinduced bylocal intra-arterial administration ofPafintherat (1988) (0)
- Inducible no synthase and interferon-Γ expression in duodenal epithelium from patients with ankylosing spondylitis (2000) (0)
- Nitric oxide donors and pro-inflammatory cytokines induce heme oxygenase 1 (HO-l) in the human differentiated intestinal epithelial cell line, Caco-2 (2000) (0)
- The Pharmacological Background (2020) (0)
- Endogenous nitric oxide attenuates the early microvascular injury provoked by indomethacin in the rat jejunum (1995) (0)
- Inhibition of endothelin release from human intestinal epithelial CAC02 and DLD-1 cells by nitric oxide donors (2000) (0)
- Protocols to assess the gastrointestinal side effects resulting from inhibition of cyclo-oxygenase isoforms. (2010) (0)
- COX-2 inhibitors, NO-NSAIDs and beyond. (2002) (0)
- Nitric Oxide and the Gastrointestinal Tract (1993) (0)
- Early phase microvascular interactions in rat jejunum between nitric oxide and vasopressin following indomethacin administration (1998) (0)
- Effects of Acute Normovolemic Gastric Mucosal Blood Flow in Nitric Oxide (1992) (0)
- Heme oxygenase-1 (HO-1) induction in human intestinal epithelial cells by sulphasalazine, 5-aminosalicyclic acid and bismuth citrate: A novel potential therapeutic mechanism (2000) (0)
- Protection against trinitrobenzene sulphonic acid-provoked colonic inflammation by endogenous oestrogens (2005) (0)
- Evolution of COX isozymes and their inhibitors - William Harvey Research Conference. (2002) (0)
- 5019Comparative receptor pharmacology, pre-clinical efficacy and pharmacokinetics of a novel, next-generation prostacyclin receptor agonist, ralinepag (APD811), in humans and rats (2017) (0)
- Activity of prostacyclin, a stable analogue, 61&-PGI1 and 6-oxo-PGFiaon canine isolated parietal cells (2007) (0)
- COMPARATIVE ACTIONS OF IONOPHORE A23187 AND BRADYKININ ON THE INTEGRITY OFBOVINE ENDOTHELIAL CELLS IN CULTURE AND ON THE RELEASE OF PROSTACYCLIN AND NITRIC OXIDE (1991) (0)
- Cytokine-stimulated nitric oxide production by Caco-2 human colonic epithelial cells is not inhibited by the corticosteroid, dexamethasone (1998) (0)
- Inhibition of platelet activating factor induced gastric mucosal damage by corticosteroids (1986) (0)
- 867 – COMPARISON OF THE ACTIVITY OF PROSTACYCLIN (PGI2) AND ITS STABLE ANALOGUE PGI1 ON THE GASTRO-INTESTINAL AND CARDIOVASCULAR SYSTEMS (1978) (0)
- Prostanoids and related mediators in gastric damage and disease (1988) (0)
- Modulation of rat gastric blood flow during PAF challenge by opiate-sensitive afferent neurones. (1989) (0)
- Actions of a proposed endogenous inhibitor of prostaglandin synthetase from plasma on cyclo-oxygenase activity in platelets and gastric mucosa [proceedings]. (1978) (0)
- Opioid-sensitive peripheral neuronal activity in the modulation of gastric mucosal injury. (1991) (0)
- Gastric Microvascular Effects of the Pro-ulcerogenic Mediator PAF-Acether (1988) (0)
- Synthesis and Inhibitory Activity on Platelet Aggregation of 13′-Aza and Other ω-Chain Modified BW245C Analogues. (1994) (0)
- Inhibition of gastric acid secretion and gastric erosions by prostacyclin and other prostaglandins. (1978) (0)
- Interactions between endogenous nitric oxide and tachykinins in the modulation of spontaneous motility of rat duodenum (1995) (0)
- PHARMACOLOGICAL APPROACH TO THE PREVENTION OF NSAID-INDUCED GASTROPATHY (1999) (0)
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