Brendan J. R. Whittle

Brendan J. R. Whittle's AcademicInfluence.com Rankings

Chemistry

#3272

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#4278

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Organic Chemistry

#519

World Rank

#599

Historical Rank

chemistry Degrees

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Chemistry

Brendan J. R. Whittle's Degrees

PhD Chemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Brendan J. R. Whittle's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo* (1997) (837)
Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion. (1989) (557)
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease (1993) (469)
Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa (1980) (397)
Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat (1990) (384)
Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species. (1978) (337)
Temporal Relationship Between Cyclooxygenase Inhibition, as Measured by Prostacyclin Biosynthesis, and the Gastrointestinal Damage Induced by Indomethacin in the Rat (1981) (310)
The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat (1993) (305)
The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation. (1989) (256)
Potent ulcerogenic actions of platelet-activating factor on the stomach (1986) (234)
Nitric oxide synthase induction and intestinal epithelial cell viability in rats. (1993) (214)
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. (1981) (212)
Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells. (1993) (201)
Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa. (1983) (177)
Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. (1987) (176)
Gastrointestinal effects of nonsteroidal anti‐inflammatory drugs (2003) (166)
Role of mucus in the repair of gastric epithelial damage in the rat. Inhibition of epithelial recovery by mucolytic agents. (1986) (161)
Nitric oxide donors increase mucus gel thickness in rat stomach. (1992) (156)
Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro. (1978) (150)
Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa (1981) (150)
Endogenous nitric oxide as a mediator of gastric mucosal vasodilatation during acid secretion. (1992) (146)
Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. (1992) (145)
Neuronal and endothelium‐derived mediators in the modulation of the gastric microcirculation: integrity in the balance (1993) (145)
Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. (1995) (140)
Gastric vasoconstrictor actions of leukotriene C4, PGF2 alpha, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo. (1985) (135)
Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat. (1990) (129)
Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin (1995) (121)
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat (1993) (121)
Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. (2012) (118)
Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo. (1992) (117)
Carbacyclin--a potent stable prostacyclin analogue for the inhibition of platelet aggregation. (1980) (115)
Pharmacological interactions between prostacyclin and thromboxanes. (1983) (114)
Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors. (2004) (112)
Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase‐3β (2006) (107)
Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat. (2005) (105)
Association of microvascular leakage with induction of nitric oxide synthase: effects of nitric oxide synthase inhibitors in various organs. (1995) (105)
Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture. (1988) (103)
The modulation of IL-6 and TNF-α release by nitric oxide following stimulation of J774 cells with LPS and IFN-γ (1995) (97)
Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins. (1976) (95)
Morphine potentiation of ethanol-induced gastric mucosal damage in the rat. Role of local sensory afferent neurons. (1990) (84)
Platelet and cardiovascular activity of the hydantoin BW245C, a potent prostaglandin analogue. (1983) (77)
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis. (2008) (77)
Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon. (1997) (77)
Nitric oxide as a factor in inflammation (1999) (77)
Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors (2000) (77)
Role of prostanoids in the protective actions of BW755C on the gastric mucosa. (1985) (75)
Nitric oxide synthase activity, viability and cyclic GMP levels in rat colonic epithelial cells: effect of endotoxin challenge. (1994) (70)
Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. (1986) (69)
Evaluation of the protection of rat gastric mucosa by a prostaglandin analogue using cellular enzyme marker and histologic techniques. (1985) (68)
Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats. (1997) (65)
COX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitors (2000) (64)
Localization of constitutive isoforms of nitric oxide synthase in the gastric glandular mucosa of the rat (1996) (62)
Nitric oxide mediates rat mucosal vasodilatation induced by intragastric capsaicin. (1992) (62)
Nitric oxide: The elusive mediator of the hyperdynamic circulation of cirrhosis? (1992) (60)
Effects of prostacyclin and a stable analogue, 6β-PGI1, on gastric acid secretion, mucosal blood flow, and blood pressure in conscious dogs (1979) (59)
Nitric oxide--a mediator of inflammation or mucosal defence. (1997) (58)
Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. (1986) (58)
Involvement of nitric oxide and prostaglandins in gastric mucosal hyperemia of portal‐hypertensive anesthetized rats (1993) (57)
Inhibition of gastric acid secretion by stress: a protective reflex mediated by cerebral nitric oxide. (1996) (52)
Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. (1986) (52)
PROSTAGLANDIN SYNTHETASE INHIBITORS (1979) (51)
A biochemical basis for the gastrointestinal toxicity of non-steroid antirheumatoid drugs. (1984) (50)
The use of stable prostaglandins to investigate prostacyclin (PGI2)-binding sites and PGI2-sensitive adenylate cyclase in human platelet membranes. (1984) (49)
The role of nitric oxide and platelet-activating factor in the inhibition by endotoxin of pentagastrin-stimulated gastric acid secretion. (1992) (48)
The nitric oxide donor, S-nitroso-N-acetyl-penicillamine, inhibits secretory activity in rat isolated parietal cells. (1993) (48)
Biosynthesis and Role of the Endothelium‐Derived Vasodilator, Nitric Oxide, in the Gastric Mucosa (1992) (47)
Role of mucus in the repair of gastric epithelial damage in the rat (1986) (46)
Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat. (1989) (46)
Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase (2008) (45)
Direct cytotoxic effect of oxygen radicals on the gastric mucosa. (1989) (44)
Modulation by heme and zinc protoporphyrin of colonic heme oxygenase-1 and experimental inflammatory bowel disease in the rat. (2007) (44)
Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs. (2001) (43)
Modulation of human colonic arachidonic acid metabolism by sulfasalazine (1985) (43)
Profile of gastrointestinal damage induced by platelet-activating factor. (1986) (42)
Gastric vascular actions of prostanoids and the dual effect of arachidonic acid. (1982) (39)
The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5‐Lipoxygenase on Anaphylactic and Inflammatory Responses (1988) (38)
Lipopolysaccharide induces Ca2+-independent nitric oxide synthase activity in rat gastric mucosal cells (1994) (37)
Effects of inhibitors of arachidonic acid metabolism on Paf‐induced gastric mucosal necrosis and haemoconcentration (1986) (37)
Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco‐2: influence of cell differentiation (1999) (37)
Cytotoxicity associated with induction of nitric oxide synthase in rat duodenal epithelial cells in vivo by lipopolysaccharide of Helicobacter pylori: inhibition by superoxide dismutase (2000) (35)
The modulation of IL-6 and TNF-alpha release by nitric oxide following stimulation of J774 cells with LPS and IFN-gamma. (1995) (35)
Platelet actions of stable carbocyclic analogues of prostacyclin. (1985) (35)
Induction of nitric oxide synthase in vivo and cell injury in rat duodenal epithelium by a water soluble extract of Helicobacter pylori (1998) (35)
Nitric oxide donors preferentially inhibit neuronally mediated rat gastric acid secretion. (1994) (34)
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents. (1981) (34)
Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea‐pigs (1987) (34)
Stimulation by carbachol of mucus gel thickness in rat stomach involves nitric oxide. (1994) (33)
The role of extracellular mucus as a protective cap over gastric mucosal damage. (1986) (30)
Nitric oxide in physiology and pathology (1995) (29)
Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C. (1992) (29)
Hemostatic mechanisms, independent of platelet aggregation, arrest gastric mucosal bleeding. (1986) (29)
Potentiation of cytokine induced iNOS expression in the human intestinal epithelial cell line, DLD-1, by cyclic AMP (1999) (29)
The endothelin explosion. A pathophysiological reality or a biological curiosity? (1990) (28)
Cardiopulmonary and Gastric Ulcerogenic Actions of Endothelin‐1 in the Guinea Pig and Rat (1989) (27)
Gastrointestinal plasma leakage in endotoxic shock. Inhibition by prostaglandin E2 and by a platelet-activating factor antagonist. (1987) (27)
Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate. (1985) (27)
Modulation by nitric oxide of spontaneous motility of the rat isolated duodenum: role of tachykinins (1996) (27)
Nitric oxide mediates the inhibition by interleukin‐1β of pentagastrin‐stimulated rat gastric acid secretion (1993) (27)
Helicobacter pylori lipopolysaccharide provokes iNOS-mediated acute systemic microvascular inflammatory responses in rat cardiac, hepatic, renal and pulmonary tissues (2001) (26)
Inhibition by 16,16-dimethyl PGE2 of ethanol-induced gastric mucosal damage and leukotriene B4 and C4 formation. (1988) (26)
Close-arterial administration of the thromboxane mimetic U-46619 induces damage to the rat gastric mucosa. (1988) (26)
Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat. (2003) (26)
Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs. (2004) (25)
Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF. (1990) (25)
Prostaglandin protection of rat colonic mucosa from damage induced by ethanol (1985) (25)
Nitric oxide and sensory afferent neurones modulate the protective effects of low-dose endotoxin on rat gastric mucosal damage. (1995) (25)
Use of the rabbit transverse stomach-strip to identify and assay prostacyclin, PGA2, PGD2 and other prostaglandins. (1979) (25)
Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. (1989) (25)
Site-specific lesion formation, inflammation and inducible nitric oxide synthase expression by indomethacin in the rat intestine. (2000) (25)
Acceleration of recovery of gastric epithelial integrity by 16,16‐dimethyl prostaglandin E2 (1985) (24)
Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins. (2013) (24)
Prostacyclin analogues inhibit canine parietal cell activity and cyclic AMP formation. (1981) (23)
The relative activity of prostacyclin (PGI2) and a stable analogue 6β‐PGI1 on the gastrointestinal and cardiovascular systems (1978) (23)
Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. (2003) (23)
Nitric oxide-modulating agents for gastrointestinal disorders (2005) (23)
Relative potency of prostacyclin, prostaglandin E1 and D2 as inhibitors of platelet aggregation in several species [proceedings]. (1977) (22)
Antithrombotic assessment and clinical potential of prostacyclin analogues. (1984) (22)
New light on the anti-colitic actions of therapeutic aminosalicylates: the role of heme oxygenase. (2010) (22)
THE GASTRIC ANTISECRETORY ACTIONS OF PROSTAGLANDIN E2 AND STABLE PROSTACYCLIN ANALOGUES AGAINST DIFFERENT SECRETAGOGUES IN PERFUSED WHOLE‐STOMACHS OF RAT OR MOUSE in vitro (1981) (22)
Advances In Drug Therapy Of Gastrointestinal Ulceration (1989) (22)
Constitutive nitric oxide modulates the injurious actions of vasopressin on rat intestinal microcirculation in acute endotoxaemia. (1994) (21)
Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. (1985) (19)
Stimulation of gastric alkaline secretion by stable prostacyclin analogues in rat and dog. (1984) (19)
Interaction between prostaglandins and cyclic AMP in the gastric mucosa. (1981) (19)
Immediate anaphylactic bronchoconstriction induces airway hyperreactivity in anaesthetized guinea‐pigs (1988) (18)
Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells (2018) (18)
Colonic microvascular integrity in acute endotoxaemia: interactions between constitutive nitric oxide and 5-lipoxygenase products. (1995) (17)
Lipopolysaccharide induces Ca(2+)-independent nitric oxide synthase activity in rat gastric mucosal cells. (1994) (17)
Failure of prostaglandin E2 and its 16,16‐dimethyl analogue to prevent the gastric mucosal damage induced by Paf (1987) (16)
Induction of nitric oxide synthase in rat intestine and its association with tissue injury (2005) (16)
Nitric oxide synthase and arginase in cells isolated from the rat gastric mucosa. (1997) (16)
Involvement of peroxynitrite in the lipid peroxidation induced by nitric oxide in rat gastric mucosa (1996) (15)
Indomethacin potentiates endotoxin‐induced blood flow reduction and histological injury in rat gastric mucosa (1988) (15)
British Journal of Clinical Pharmacology review series. Clinical research methods in gastroenterology. (2003) (15)
Prostacyclin-sensitive adenylate cyclase in cultured myocytes: differences between rabbit aorta and mesenteric artery. (1984) (14)
Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-receptor agonist properties. (1996) (14)
Some actions of prostacyclin (PGI2) on the cardiovascular system and the gastric microcirculation. (1978) (14)
Ulceration induced by an endoperoxide analog and by indomethacin in the canine stomach. (1983) (14)
Helicobacter pylori lipopolysaccharide-provoked injury to rat gastroduodenal microvasculature involves inducible nitric oxide synthase. (2001) (14)
Biological Activities of Some Metabolites and Analogues of Prostacyclin (1981) (14)
New dogmas or old? (2003) (13)
The differential response of a novel bioassay tissue, the rabbit transverse stomach-strip, to prostacyclin (PGI2) and other prostaglandins [proceedings]. (1977) (13)
The cardiovascular and platelet actions of 9β‐methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey (1985) (12)
Modulation by prostanoids of the release of inflammatory mediators from mast cells: involvement in mucosal protection? (1993) (12)
Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats. (1998) (12)
Nitric oxide and the gut injury induced by non-steroidal anti-inflammatory drugs (2004) (11)
Nitric oxide in physiology and pathology (2004) (11)
Assessment of anticolitic drugs in the trinitrobenzene sulfonic acid (TNBS) rat model of inflammatory bowel disease. (2003) (11)
Involvement of endogenous nitric oxide in the inhibition by endotoxin and interleukin‐1β of gastric acid secretion (1994) (10)
Biological actions of prostacyclin and its pharmacological use in platelet studies. (1985) (9)
Gastric Venous Prostaglandin Concentrations during Basal and Stimulated Acid Secretion in Dog (1982) (8)
Microsomal Prostaglandin E Synthase-1 Expression in Inflammatory Conditions Is Downregulated by Dexamethasone: Seminal Role of the Regulatory Phosphatase MKP-1 (2017) (8)
Nitric oxide mediates the inhibition by interleukin-1 beta of pentagastrin-stimulated rat gastric acid secretion. (1993) (8)
Synthesis and platelet aggregation inhibiting activity of 1′-carboxyl modified hydantoin prostaglandin analogues (1989) (8)
Nitric oxide and the gut injury induced by non-steroidal anti-in ammatory drugs (8)
Endogenous nitric oxide in the maintenance of rat microvascular integrity against widespread plasma leakage following abdominal laparotomy (1999) (8)
The role of leukotrienes in the pathogenesis of gastric ulceration. (1988) (7)
Detrimental effects of oestradiol on cysteamine-induced gastroduodenal ulceration in the female rat (1999) (7)
GW273629 is a highly selective, short-acting iNOS (NOS-2) inhibitor both in vitro and in vivo: beneficial effects in endotoxin shock (2000) (7)
Nitric oxide modulates the gastrointestinal plasma extravasation following intraabdominal surgical manipulation in rats. (1999) (6)
[Role of nitric oxide in maintaining the mucosal integrity and in inflammatory gastrointestinal diseases]. (1996) (6)
Formation of prostacyclin and its product 6-oxo-PGF1alpha by the gastric mucosa of several species [proceedings]. (1978) (6)
Increase In Gastric Intramucosal Hydrogen Ion Concentration Following Endotoxin Challenge In The Rat And The Actions Of Nitric Oxide Synthase Inhibitors (2001) (6)
Biosynthesis of endogenous arachidonate products involved in gastric damage and protection (1984) (6)
Gastric antisecretory and cardiovascular actions of a stable 16-phenoxy prostacyclin analog in the dog. (1980) (6)
Gastrointestinal damage induced by platelet-activating factor (1988) (5)
Endogenous bacteria-triggered inducible nitric oxide synthase activation protects the ovariectomized rat stomach (2001) (5)
Inhibition of inducible nitric oxide synthase (iNOS) and induction of heme oxygenase-1 by bismuth preparations in human intestinal epithelial cells (2000) (5)
Effects of prostaglandin E2 methyl analogues on the anti‐inflammatory and gastric erosive activity of indomethacin (1976) (5)
Laboratory methods for studying the role of eicosanoids in inflammatory bowel disease (1988) (5)
Assessment of the actions of prostanoids in the protection and repair of the gastric mucosa. (1986) (5)
Ep2 Receptors Play A Key Role In Mediating The Anti-Proliferative Activity Of Treprostinil In Smooth Muscle Cells Derived From The Lungs Of Pulmonary Hypertensive Patients (2015) (4)
Pharmacology of the single isomer, esuberaprost (beraprost-314d) on pulmonary vascular tone, IP receptors and human smooth muscle proliferation in pulmonary hypertension. (2019) (4)
Characterisation of nitric oxide synthase activity in the rat colonic mucosa and muscle after endotoxin and in a model of colitis (1994) (4)
Aminoguanidine promotes vasoconstriction and leukocyte adherence in rat mesentery through inhibition of constitutive nitric oxide synthase (1995) (4)
Attenuation of Helicobacter pylori endotoxin-provoked rat intestinal inflammation by selective inhibition of the inducible nitric oxide synthase (2001) (4)
The Journal of Rheumatology duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. Lymphocytic infiltration and expression of inducible nitric oxide synthase in human (2003) (4)
The Therapeutic and Toxic Effects of Anti-Inflammatory Drugs Which Interfere with Arachidonic Acid Metabolism (1980) (4)
Synthesis and Inhibitory Activity on Platelet Aggregation of 13′‐Aza and Other ω‐Chain Modified BW245C Analogues (1994) (4)
Bradykinin stimulates PGE2 release in cell fractions isolated from the rat gastric mucosa via a B1 receptor. (1992) (4)
Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat (2005) (4)
Effects of prostacyclin and a stable analogue, 6-beta-PGI1, on gastric acid secretion, mucosal blood flow, and blood pressure in conscious dogs. (1979) (4)
Endotoxin can decrease isolated rat parotid acinar cell amylase secretion in a nitric oxide-independent manner. (2005) (4)
Beneficial effect of P54, A novel curcumin preparation in Tnbs-induced colitis in rats (2001) (3)
Nitric oxide in vascular, intestinal and neuronal tissue: Interactions in the gut (1993) (3)
Involvement of neuronal processes and nitric oxide in the inhibition by endotoxin of pentagastrin-stimulated sastric acid secretion (1994) (3)
Gastric effects of PAF. (1989) (3)
Pharmacological approach to the prevention of non-steroidal anti-inflammatory drug-induced gastropathy. (1999) (3)
New targets for anti-ulcer drugs. (1988) (2)
Pharmacological manipulation of vasoactive mediators in gastric damage and protection (1990) (2)
Some characteristics of the gastric antisecretory actions of prostaglandins in mammalian perfused whole-stomachs in vitro [proceedings]. (1979) (2)
Prostacyclin and its analogues for the therapy of thromboembolic disorders. (1984) (2)
Metabolism of arginine to citrulline by rat gastric mucosal cells. (1996) (2)
Gastric mucosal nitric oxide synthase activity: inhibition by phosphorylation, arginine analogues and trifluoperazine. (1994) (2)
Inflammatory and protective mediators in experimental intestinal inflammation (1991) (2)
Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future (2003) (2)
Interactions of pro-inflammatory and vasoactive mediators with nitric oxide in the regulation of rat vascular permeability during laparotomy. (2000) (2)
Heme oxygenase-1 (HO-l) induction in human intestinal epithelial cells by sulphasalazine and 5-aminosalicylic acid: A potential therapeutic mechanism (2000) (2)
Rapid induction of the antioxidant, heme oxygenase-1 (HO-1) in human intestinal epithelial cells: Interaction with glutathione levels (2001) (2)
Safer non-steroidal anti-inflammatory drugs: are cyclo-oxygenase inhibitors or nitric oxide non-steroidal anti-inflammatory drugs the grand finale? (2002) (2)
Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs (2004) (1)
A new era for gastrointestinal research — novel therapeutic targets for drug development (2004) (1)
Involvement of the Eicosanoids, Thromboxane A 2 and Leukotriene C 4 in Gastric Mucosal Damage (1988) (1)
5-amino salicylic acid induced depletion of glutathione protects the colon against trinitrobenzene sulphonic acid injury through heme oxygenase-1 enzyme expression (2006) (1)
Effects of prostacyclin (PGI2), PGI1 and 6-oxo-PGF1alpha on the rat gastric mucosa [proceedings]. (1978) (1)
Role of Eicosanoids in the Pathogenesis of Inflammatory Bowel Diseases (1985) (1)
5-amino salicylic acid protects the colon against trinitrobenzene sulphonic acid injury through hemoxigenase-1 enzyme induction (2005) (1)
Synthesis and Platelet Aggregation Inhibiting Activity of Acid Side‐chain Modified Hydantoin Prostaglandin Analogues (1993) (1)
Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat (2005) (1)
Role of glutathione in the induction of hemoxygenase-1 enzyme in intestinal epithelial cells (2005) (1)
Inhibition of gastric motility changes following PAF-acether and endotoxin by L-652, 731 (1988) (1)
Pharmacokinetics and pre-clinical efficacy of ralinepag (APD811) in humans and rats (2017) (1)
Activity of prostacyclin, a stable analogue, 6 beta-PGI1 and 6-oxo-PGF1 alpha on canine isolated parietal cells [proceedings]. (1979) (1)
Potentiation of cytokine-induced nitric oxide synthase activity of cyclic AMP derivatives in DLD-1 human intestinal epithelial cells (1998) (0)
Modulators of Inducible Nitric Oxide Synthase: Potential Drugs for the Therapy of Gut Inflammation? (2002) (0)
Actions of Selective and Non-selective Nitric Oxide Synthase Inhibitors on Multiple-Organ Microvacular Injury Provoked by Lipopolysaccharide (1999) (0)
Prostacyclin inhibition and ulcerogenesis (1981) (0)
Widespread intestinal vascular leakage accompanies inos expression following multiple doses of indomethacin in the rat (2000) (0)
Interaction between PAF-acether and thromboxane in endotoxin-induced intestinal damage (1988) (0)
Inhibition of inducible nitric oxide synthase (iNOS) by bismuth preparations and sulphasalasine in human intestinal epithelial cells (2000) (0)
Early phase microvascular interactions in rat jejunum between nitric oxide and vasopressin following indomethacin administration (1998) (0)
Synthesis and Platelet Aggregation Inhibiting Activity of 1′-Carboxyl Modified Hydantoin Prostaglandin Analogues. (1990) (0)
Gastric mucosal damageinduced bylocal intra-arterial administration ofPafintherat (1988) (0)
Inducible no synthase and interferon-Γ expression in duodenal epithelium from patients with ankylosing spondylitis (2000) (0)
Nitric oxide donors and pro-inflammatory cytokines induce heme oxygenase 1 (HO-l) in the human differentiated intestinal epithelial cell line, Caco-2 (2000) (0)
The Pharmacological Background (2020) (0)
Endogenous nitric oxide attenuates the early microvascular injury provoked by indomethacin in the rat jejunum (1995) (0)
Inhibition of endothelin release from human intestinal epithelial CAC02 and DLD-1 cells by nitric oxide donors (2000) (0)
Protocols to assess the gastrointestinal side effects resulting from inhibition of cyclo-oxygenase isoforms. (2010) (0)
COX-2 inhibitors, NO-NSAIDs and beyond. (2002) (0)
Nitric Oxide and the Gastrointestinal Tract (1993) (0)
Early phase microvascular interactions in rat jejunum between nitric oxide and vasopressin following indomethacin administration (1998) (0)
Effects of Acute Normovolemic Gastric Mucosal Blood Flow in Nitric Oxide (1992) (0)
Heme oxygenase-1 (HO-1) induction in human intestinal epithelial cells by sulphasalazine, 5-aminosalicyclic acid and bismuth citrate: A novel potential therapeutic mechanism (2000) (0)
Protection against trinitrobenzene sulphonic acid-provoked colonic inflammation by endogenous oestrogens (2005) (0)
Evolution of COX isozymes and their inhibitors - William Harvey Research Conference. (2002) (0)
5019Comparative receptor pharmacology, pre-clinical efficacy and pharmacokinetics of a novel, next-generation prostacyclin receptor agonist, ralinepag (APD811), in humans and rats (2017) (0)
Activity of prostacyclin, a stable analogue, 61&-PGI1 and 6-oxo-PGFiaon canine isolated parietal cells (2007) (0)
COMPARATIVE ACTIONS OF IONOPHORE A23187 AND BRADYKININ ON THE INTEGRITY OFBOVINE ENDOTHELIAL CELLS IN CULTURE AND ON THE RELEASE OF PROSTACYCLIN AND NITRIC OXIDE (1991) (0)
Cytokine-stimulated nitric oxide production by Caco-2 human colonic epithelial cells is not inhibited by the corticosteroid, dexamethasone (1998) (0)
Inhibition of platelet activating factor induced gastric mucosal damage by corticosteroids (1986) (0)
867 – COMPARISON OF THE ACTIVITY OF PROSTACYCLIN (PGI2) AND ITS STABLE ANALOGUE PGI1 ON THE GASTRO-INTESTINAL AND CARDIOVASCULAR SYSTEMS (1978) (0)
Prostanoids and related mediators in gastric damage and disease (1988) (0)
Modulation of rat gastric blood flow during PAF challenge by opiate-sensitive afferent neurones. (1989) (0)
Actions of a proposed endogenous inhibitor of prostaglandin synthetase from plasma on cyclo-oxygenase activity in platelets and gastric mucosa [proceedings]. (1978) (0)
Opioid-sensitive peripheral neuronal activity in the modulation of gastric mucosal injury. (1991) (0)
Gastric Microvascular Effects of the Pro-ulcerogenic Mediator PAF-Acether (1988) (0)
Synthesis and Inhibitory Activity on Platelet Aggregation of 13′-Aza and Other ω-Chain Modified BW245C Analogues. (1994) (0)
Inhibition of gastric acid secretion and gastric erosions by prostacyclin and other prostaglandins. (1978) (0)
Interactions between endogenous nitric oxide and tachykinins in the modulation of spontaneous motility of rat duodenum (1995) (0)
PHARMACOLOGICAL APPROACH TO THE PREVENTION OF NSAID-INDUCED GASTROPATHY (1999) (0)

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What Schools Are Affiliated With Brendan J. R. Whittle?

Brendan J. R. Whittle is affiliated with the following schools:

Aston University