Bartholomew.m. Sefton
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Bartholomew.m. Seftonbiology Degrees
Biology
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#11956
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Virology
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#203
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Molecular Biology
#1148
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Neuroscience
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Biology
Bartholomew.m. Sefton's Degrees
- PhD Molecular Biology University of California, Berkeley
- Bachelors Biochemistry University of California, Berkeley
Why Is Bartholomew.m. Sefton Influential?
(Suggest an Edit or Addition)Bartholomew.m. Sefton's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transforming gene product of Rous sarcoma virus phosphorylates tyrosine (1980) (1798)
- Detection and quantification of phosphotyrosine in proteins. (1983) (763)
- Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus (1981) (516)
- Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus (1980) (438)
- Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. (1989) (431)
- Acid and base hydrolysis of phosphoproteins bound to immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins. (1989) (376)
- The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain (1989) (330)
- Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation. (1985) (306)
- Protein kinases. (1989) (301)
- Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine. (1988) (280)
- Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. (1982) (274)
- The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid (1982) (269)
- Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites (1984) (266)
- Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase (1990) (254)
- The covalent modification of eukaryotic proteins with lipid (1987) (253)
- Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II* (1998) (239)
- Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion (1986) (222)
- Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. (1993) (197)
- Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. (1987) (195)
- Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti‐immunoglobulin. (1990) (183)
- Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases (1993) (178)
- Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394. (1995) (177)
- Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation (1986) (173)
- Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases (1992) (169)
- Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness (1978) (167)
- Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts. (1988) (164)
- Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo (1978) (164)
- Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site (1990) (162)
- Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog (1985) (162)
- Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src (1986) (144)
- Specific Dephosphorylation of the Lck Tyrosine Protein Kinase at Tyr-394 by the SHP-1 Protein-tyrosine Phosphatase* (2001) (141)
- Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein (1984) (140)
- Tyrosine phosphorylation of CD22 during B cell activation. (1992) (140)
- The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity (1986) (137)
- Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells (1984) (136)
- Immediate glycosylation of Sindbis virus membrane proteins (1977) (130)
- Cyanogen bromide cleavage and proteolytic peptide mapping of proteins immobilized to membranes. (1991) (130)
- Direct identification of palmitic acid as the lipid attached to p21ras (1986) (127)
- Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus. (1980) (126)
- Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes. (1993) (116)
- Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells (1984) (111)
- The entry into host cells of Sindbis virus, vesicular stomatitis virus and Sendai virus (1978) (110)
- Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. (1981) (108)
- Coronavirus proteins: structure and function of the oligosaccharides of the avian infectious bronchitis virus glycoproteins (1982) (107)
- Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. (1982) (107)
- Coronavirus proteins: biogenesis of avian infectious bronchitis virus virion proteins (1982) (104)
- Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck. (1989) (97)
- Role of tyrosine kinases in lymphocyte activation. (1994) (94)
- Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase (1995) (93)
- Enzymatic Iodination of Sindbis Virus Proteins (1973) (91)
- Effect of the viral proteins on the fluidity of the membrane lipids in Sindbis virus. (1974) (88)
- Transfer of proteins to membranes facilitates both cyanogen bromide cleavage and two-dimensional proteolytic mapping. (1990) (88)
- The Activated Form of the Lck Tyrosine Protein Kinase in Cells Exposed to Hydrogen Peroxide Is Phosphorylated at Both Tyr-394 and Tyr-505* (1997) (85)
- Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium (1992) (73)
- Structural analysis of virion proteins of the avian coronavirus infectious bronchitis virus (1982) (73)
- Two small virus-specific polypeptides are produced during infection with Sindbis virus (1979) (69)
- Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity (1980) (69)
- Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia (1994) (68)
- Phosphopeptide Mapping and Phosphoamino Acid Analysis on Cellulose Thin-Layer Plates (1998) (67)
- Two lck transcripts containing different 5' untranslated regions are present in T cells (1987) (66)
- Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src of Prague Rous sarcoma virus (1986) (62)
- Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development (1990) (61)
- Sindbis virus glycoproteins: effect of the host cell on the oligosaccharides (1975) (59)
- Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity (1979) (58)
- Tyrosine protein kinases. (1984) (56)
- Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells (1992) (54)
- Relationship of polypeptide products of the transforming gene of Rous sarcoma virus and the homologous gene of vertebrates. (1980) (54)
- Coronavirus multiplication: locations of genes for virion proteins on the avian infectious bronchitis virus genome (1984) (51)
- The role of tyrosine protein phosphorylation in lymphocyte activation. (1991) (51)
- Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid-specific promoters (1988) (49)
- Biosynthesis of the Sindbis Virus Carbohydrates (1973) (45)
- Phosphorylation and metabolism of the transforming protein of Rous sarcoma virus (1982) (44)
- Virus-Dependent Glycosylation (1976) (42)
- Protein kinases and viral transformation (1982) (42)
- Antiserum specific for the carboxy terminus of the transforming protein of Rous sarcoma virus (1982) (41)
- Characterization of a small, nonstructural viral polypeptide present late during infection of BHK cells by Semliki Forest virus (1980) (40)
- Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase. (1992) (40)
- Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta. (1994) (40)
- Activation of the Lck Tyrosine-protein Kinase by the Binding of the Tip Protein of Herpesvirus Saimiri in the Absence of Regulatory Tyrosine Phosphorylation* (1999) (40)
- Phosphorylation of a Src Kinase at the Autophosphorylation Site in the Absence of Src Kinase Activity* (2000) (38)
- The lck tyrosine protein kinase. (1991) (34)
- The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity. (1999) (34)
- Synthesis of coronavirus mRNAs: kinetics of inactivation of infectious bronchitis virus RNA synthesis by UV light (1982) (34)
- Analysis of the sites in p56lck whose phosphorylation is induced by tetradecanoyl phorbol acetate. (1990) (32)
- The transforming proteins of PRCII virus and Rous sarcoma virus form a complex with the same two cellular phosphoproteins (1982) (32)
- The viral tyrosine protein kinases. (1986) (31)
- Oncogenes encoding protein kinases (1985) (30)
- Stimulation of Phosphorylation of Tyr394 by Hydrogen Peroxide Reactivates Biologically Inactive, Non-membrane-bound Forms of Lck (*) (1996) (30)
- Overview of protein phosphorylation. (2001) (30)
- Evidence that there exist four classes of RNA tumor viruses which encode proteins with associated tyrosine protein kinase activities (1981) (28)
- Most of the substrates of oncogenic viral tyrosine protein kinases can be phosphorylated by cellular tyrosine protein kinases in normal cells. (1988) (28)
- Some lymphoid cell lines transformed by Abelson murine leukemia virus lack a major 36,000-dalton tyrosine protein kinase substrate (1983) (27)
- Polymorphism of avian sarcoma virus src proteins (1979) (27)
- Tyrosine phosphorylation of VCP, the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to stimulation by sodium vanadate and hydrogen peroxide. (1994) (27)
- Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions. (2000) (26)
- Relative contributions of desolvation, inter‐ and intramolecular interactions to binding affinity in protein kinase systems (2005) (26)
- Inhibition of the activity of SRC and Abl tyrosine protein kinases by the binding of the Wiskott-Aldrich syndrome protein. (2003) (26)
- The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro. (2002) (25)
- Cytoskeletal organization, vinculin-phosphorylation, and fibronectin expression in transformed fibroblasts with different cell morphologies. (1986) (25)
- Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein. (2007) (23)
- Cytoskeletal targets for viral transforming proteins with tyrosine protein kinase activity. (1982) (22)
- Measurement of stoichiometry of protein phosphorylation by biosynthetic labeling. (1991) (21)
- Amino-terminal sequence analysis of alphavirus polypeptides (1981) (21)
- From c-src to v-src, or the case of the missing C terminus. (1986) (20)
- Protein phosphorylation. Part B. Analysis of protein phosphorylation, protein kinase inhibitors, and protein phosphatases. (1991) (17)
- Analysis of the activity and phosphorylation of the lck protein in lymphoid cells. (1989) (15)
- Complete exchange of viral cholesterol. (1979) (15)
- Labeling Cultured Cells with 32Pi and Preparing Cell Lysates for Immunoprecipitation (1999) (15)
- Analysis of Protein Phosphorylation (2003) (15)
- Structural studies of spherical viruses. (1974) (13)
- Studies on the structure and function of the avian sarcoma virus transforming-gene product. (1980) (13)
- Overview of Protein Phosphorylation (1998) (12)
- PHOSPHORYLATION OF TYROSINE: A MECHANISM OF TRANSFORMATION SHARED BY A NUMBER OF OTHERWISE UNRELATED RNA TUMOR VIRUSES (1980) (11)
- Labeling Cultured Cells with 32Pi and Preparing Cell Lysates for Immunoprecipitation (1997) (10)
- Creation and characterization of temperature-sensitive mutants of the lck tyrosine protein kinase (1992) (7)
- Overview of Protein Phosphorylation (1995) (7)
- 11 – The Role of Tyrosine Protein Kinases in the Action of Growth Factors (1985) (7)
- The sequence of chicken c-yes and p61c-yes. (1989) (7)
- Chicken proto-oncogene c-ros cDNA clones: identification of a c-ros RNA transcript and deduction of the amino acid sequence of the carboxyl terminus of the c-ros product. (1987) (7)
- Ultraviolet Light-induced Stimulation of the JNK Mitogen-activated Protein Kinase in the Absence of Src Family Tyrosine Kinase Activation* (2000) (6)
- Protein phosphorylation. Part A. Protein kinases: assays, purification, antibodies, functional analysis, cloning, and expression. (1991) (5)
- Generation and characterization of transforming variants of the lck tyrosine protein kinase. (1992) (5)
- Transcriptional Activation ofIckbyRetrovirus Promoter Insertion between TwoLymphoid-Specific Promoters (1988) (4)
- The Rous Sarcoma Virus SRC Gene Product Is a Protein Kinase that Phosphorylates Tyrosine (1979) (4)
- Protein kinases : assays, purification, antibodies, functional analysis, cloning, and expression (1991) (3)
- Phosphoamino Acid Analysis (1997) (2)
- Phosphoamino Acid Analysis (1999) (2)
- Labeling Cultured Cells with 32Pi and Preparing Cell Lysates for Immunoprecipitation (1997) (2)
- Organization of the IBV genome. (1984) (2)
- Detection of Phosphorylation by Immunological Techniques (1995) (2)
- Biosynthesis oftheSindbis Virus Carbohydrates (1973) (1)
- Transforming gene product of Rous phosphorylates tyrosine (2016) (1)
- Oncogenes and the molecular origins of cancer: edited by R.A. Weinberg, Cold Spring Harbor Laboratory Press, 1990, $97.00 (x + 367 pages) ISBN 0 87969 336 3 (1990) (1)
- Analysis of Phosphorylation of Unlabeled Proteins (1997) (1)
- Activated Ick Tyrosine Protein Kinase Stimulates Antigen- (1)
- ANALYSIS OF VSV GLYCOPROTEIN STRUCTURE AND GENOME STRUCTURE USING CLONED DNA (1980) (0)
- Phosphoamino acid analysis. (2001) (0)
- Vinculin distribution and tyrosine phosphorylation in transformed chick embryo fibroblasts (1984) (0)
- TheAbsence ofMyristic AcidDecreases MembraneBinding of p6Osrc butDoesNotAffect Tyrosine Protein Kinase Activity (1986) (0)
- Diverse Mitogenic AgentsInducethePhosphorylation ofTwo Related 42,000-Dalton Proteins on Tyrosine inQuiescent ChickCells (1984) (0)
- Molecular Biology and Virology Laboratory (1994) (0)
- Differential Effects ofExpression oftheCD45Tyrosine Protein Phosphatase on theTyrosine Phosphorylation ofthe ick, fin,andc-srcTyrosine Protein Kinases (1993) (0)
- Related Sequences in the Cytoplasmic Domains of CD 4 and CD 8 Mediate Binding to the Amino-Terminal Domain of the p 561 ck Tyrosine Protein Kinase (0)
- Tyrosine phosphorylation of 8 identified substrates by p 60s r c lacking myristic acid fails to cause transformation (1986) (0)
- Product ofInVitro Translation oftheRousSarcoma Virus src GeneHasProtein Kinase Activity (1979) (0)
- Conformational analysis of the Tip protein from Herpesvirus saimiri with hydrogen exchange and mass spectrometry (2006) (0)
- Analysis of Protein Phosphorylation (2004) (0)
- Vesicular stomatitis virus glycoprotein is anchored in the viral membrane by a hydrophobic domain near the COOH terminus ( transmembrane protein sequence / signal sequence / cDNA cloning / DNA sequence determination ) (0)
- Myristic Acid, aRareFatty Acid, IstheLipid Attached tothe Transforming Protein ofRousSarcoma Virus and ItsCellular Homolog (1985) (0)
- B-cell activation by wild type and mutant Ig-beta cytoplasmic domains. (1994) (0)
- B-Cell Activation by Wild Type and Mutant Ig-β Cytoplasmic Domains (1994) (0)
- Analysis of Protein Phosphorylation (2012) (0)
- tyrosine protein kinase. the amino-terminal domain of the p56lck domains of CD4 and CD8 mediate binding to Short related sequences in the cytoplasmic (2013) (0)
- Analysis of Protein Phosphorylation (2003) (0)
- Mutation of NH2-terminal glycine of p6Osrc prevents both myristoylation and morphological transformation acid/oligonucleotide-directed (0)
- Analysis of the sequence of amino- tyrosine phosphorylation (Rous sarcoma virus/p60sr/avian sarcoma viruses Y73 and PRCHI/A (2016) (0)
- Analysis of Protein Phosphorylation (2007) (0)
- Neither Arginine norHistidine CanCarry OuttheFunction of Lysine-295 intheATP-Binding Site ofp6Osrc (1986) (0)
- Identification of an Additional Site of Tyrosine Phosphorylation in p6OV-src of Prague Rous Sarcoma Virus (2003) (0)
- Complete Exchange of Viral Cholesterolt (2001) (0)
- Comparison oftheExpression ofthesrcGeneofRous Sarcoma Virus InVitro andInVivo (1978) (0)
- Myristic AcidIsAttached totheTransforming Protein ofRous Sarcoma Virus During orImmediately After Synthesis andIsPresent inBothSoluble andMembrane-Bound FormsoftheProtein (1984) (0)
- Oncogenic Activation oftheLckProtein Accompanies Translocation oftheLCKGeneintheHumanHSB2T-Cell Leukemia (1994) (0)
- Creation andCharacterization ofTemperature-Sensitive Mutants oftheIckTyrosine Protein Kinase (1992) (0)
- The initial glycosylation of the Sindbis virus membrane proteins. (1978) (0)
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