Baljit S. Khakh
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Neuroscientist and Professor of Physiology and Neurobiology at the University of California, Los Angeles
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Baljit S. Khakhbiology Degrees
Biology
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#8296
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Physiology
#240
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#440
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Neuroscience
#1357
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#1403
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Biology
Why Is Baljit S. Khakh Influential?
(Suggest an Edit or Addition)According to Wikipedia, Baljit Singh Khakh is a British neuroscientist and Professor of Physiology and Neurobiology at the University of California, Los Angeles. Education and career Baljit Khakh completed his Ph.D. at University of Cambridge in 1995 in the laboratory of Patrick PA Humphrey. He then completed postdoctoral fellowships first in the laboratory of Graeme Henderson at the University of Bristol, then in the laboratories of Henry A. Lester and Norman Davidson at California Institute of Technology. In 2001, Khakh joined the faculty as a Group Leader at the MRC Laboratory of Molecular Biology. In 2006, Khakh moved to the University of California, Los Angeles and is now Professor of Physiology and Neurobiology. In 2013, Khakh was named a Fellow of the Royal Society of Biology as well as awarded the National Institutes of Health Director's Pioneer Award. In 2018, he was awarded the Paul G. Allen Distinguished Investigator Award. In 2019, Khakh received a R35 Outstanding Investigator Award from NINDS.
Baljit S. Khakh's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Astrocyte scar formation aids central nervous system axon regeneration (2016) (1197)
- Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging (2012) (1080)
- P2X receptors as cell-surface ATP sensors in health and disease (2006) (819)
- Diversity of astrocyte functions and phenotypes in neural circuits (2015) (777)
- Reactive astrocyte nomenclature, definitions, and future directions (2021) (698)
- International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. (2001) (672)
- Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice (2014) (446)
- Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence (2017) (440)
- CaImAn an open source tool for scalable calcium imaging data analysis (2019) (400)
- Ca2+ signaling in astrocytes from IP3R2−/− mice in brain slices and during startle responses in vivo (2015) (398)
- Molecular physiology of p2x receptors and atp signalling at synapses (2001) (378)
- Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds (1999) (367)
- ATP-gated P2X cation-channels (2009) (318)
- Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses (2013) (314)
- Allosteric Control of Gating and Kinetics at P2X4Receptor Channels (1999) (310)
- Neuromodulation by Extracellular ATP and P2X Receptors in the CNS (2012) (294)
- Contribution of Calcium Ions to P2X Channel Responses (2004) (280)
- Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-Mediated Slow Inward Currents in Pyramidal Neurons (2008) (254)
- TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive d-Serine Release (2013) (251)
- Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. (2017) (247)
- New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo (2016) (246)
- TRPA1 channels regulate astrocyte resting calcium levels and inhibitory synapse efficacy via GAT-3 (2011) (241)
- ATP Excites Interneurons and Astrocytes to Increase Synaptic Inhibition in Neuronal Networks (2004) (225)
- The Emerging Nature of Astrocyte Diversity. (2019) (225)
- A genetically targeted optical sensor to monitor calcium signals in astrocyte processes (2010) (220)
- Electrophysiological properties of P2X‐purinoceptors in rat superior cervical, nodose and guinea‐pig coeliac neurones. (1995) (212)
- Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway (2014) (209)
- The double life of ATP. (2009) (206)
- Probing the Complexities of Astrocyte Calcium Signaling. (2016) (199)
- Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior (2018) (191)
- State-dependent cross-inhibition between transmitter-gated cation channels (2000) (189)
- Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety (2001) (184)
- Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors (2012) (175)
- Astrocyte calcium signaling: from observations to functions and the challenges therein. (2015) (170)
- Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue (2019) (165)
- ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain. (1998) (154)
- Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice (2016) (152)
- New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling (2015) (151)
- ATP Modulation of Excitatory Synapses onto Interneurons (2003) (149)
- Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy (2007) (140)
- A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP (2018) (139)
- Improved tools to study astrocytes (2020) (138)
- Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease (2017) (124)
- Astrocyte molecular signatures in Huntington’s disease (2019) (117)
- Vesicular ATP Is the Predominant Cause of Intercellular Calcium Waves in Astrocytes (2007) (114)
- Patch–clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels (2008) (106)
- An Angstrom Scale Interaction between Plasma Membrane ATP-Gated P2X2 and α4β2 Nicotinic Channels Measured with Fluorescence Resonance Energy Transfer and Total Internal Reflection Fluorescence Microscopy (2005) (102)
- ATP-gated ion channels mediate adaptation to elevated sound levels (2013) (98)
- Bulk Loading of Calcium Indicator Dyes to Study Astrocyte Physiology: Key Limitations and Improvements Using Morphological Maps (2011) (97)
- Vesicular ATP is the predominant cause of intercellular calcium waves in astrocytes. (2007) (97)
- All the light that we can see: a new era in miniaturized microscopy (2018) (95)
- Behaviorally consequential astrocytic regulation of neural circuits (2020) (90)
- Dynamic Selectivity Filters in Ion Channels (1999) (89)
- Breakdown of spatial coding and interneuron synchronization in epileptic mice (2020) (89)
- Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors) (2011) (87)
- An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales (2018) (81)
- Modulation of fast synaptic transmission by presynaptic ligand-gated cation channels. (2000) (81)
- P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin (2010) (79)
- Monitoring astrocyte calcium microdomains with improved membrane targeted GCaMP reporters. (2010) (79)
- Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X2-green fluorescent protein receptors (2001) (79)
- Control of P2X2 Channel Permeability by the Cytosolic Domain (2002) (77)
- Gated Access to the Pore of a P2X Receptor (2010) (69)
- ATP‐gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurons of the rat. (1997) (69)
- Stress gates an astrocytic energy reservoir to impair synaptic plasticity (2020) (68)
- Contribution of Transmembrane Regions to ATP-gated P2X2 Channel Permeability Dynamics* (2005) (67)
- Genetically Encoded Calcium Indicators and Astrocyte Calcium Microdomains (2013) (66)
- A study on P2x purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens (1995) (65)
- Active role of capillary pericytes during stimulation-induced activity and spreading depolarization (2018) (64)
- Hyperpolarization‐activated cationic currents (Ih) in neurones of the trigeminal mesencephalic nucleus of the rat (1998) (61)
- Time-Resolved Measurement of State-Specific P2X2 Ion Channel Cytosolic Gating Motions (2004) (59)
- Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1 (2008) (58)
- Molecular Shape, Architecture, and Size of P2X4 Receptors Determined Using Fluorescence Resonance Energy Transfer and Electron Microscopy* (2008) (55)
- Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation (2019) (53)
- Astrocyte–Neuron Interactions in the Striatum: Insights on Identity, Form, and Function (2019) (52)
- A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies (2020) (51)
- Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. (1994) (50)
- Tracking transmitter-gated P2X cation channel activation in vitro and in vivo (2008) (49)
- Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system. (2014) (46)
- P2 purinoceptor antagonist properties of pyridoxal-5-phosphate. (1994) (45)
- Imaging P2X4 Receptor Lateral Mobility in Microglia (2012) (45)
- Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable (2020) (44)
- Allosteric Modulation of Ca2+ flux in Ligand-gated Cation Channel (P2X4) by Actions on Lateral Portals* (2012) (42)
- P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus (2016) (40)
- Molecular basis of astrocyte diversity and morphology across the CNS in health and disease (2022) (39)
- Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin (2014) (37)
- Adenosine and ATP: progress in their receptors' structures and functions. (1998) (37)
- Tunable Calcium Current through TRPV1 Receptor Channels* (2008) (36)
- Neuronal P2X2 Receptors Are Mobile ATP Sensors That Explore the Plasma Membrane When Activated (2011) (36)
- Astrocytes and Huntington's disease. (2014) (35)
- Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation (2021) (30)
- Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats (2021) (29)
- Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK (2021) (28)
- Reflections on the past two decades of neuroscience (2020) (28)
- Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors (2001) (27)
- ATP-gated P2X receptors in health and disease (2014) (25)
- ATP-gated P2X receptors on excitatory nerve terminals onto interneurons initiate a form of asynchronous glutamate release (2009) (24)
- New insights on P2X purinoceptors (1995) (23)
- Imaging intracellular Ca²⁺ signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators. (2014) (23)
- On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory and Neuropathic Pain (2010) (17)
- Measuring Near Plasma Membrane and Global Intracellular Calcium Dynamics in Astrocytes (2009) (16)
- New insights on P 2 x purinoceptors (16)
- Visualizing Astrocyte Morphology Using Lucifer Yellow Iontophoresis. (2019) (14)
- Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels (2009) (14)
- P 2 X 4 receptors in activated C 8B 4 cells of cerebellar microglial origin (2010) (14)
- Inhibitory Interactions between Phosphorylation Sites in the C Terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid-type Glutamate Receptor GluA1 Subunits* (2014) (13)
- The selective P2X purinoceptor agonist, β,γ-methylene-L-adenosine 5′-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors (1995) (11)
- The selective P2X purinoceptor agonist, beta,gamma-methylene-L-adenosine 5'-triphosphate, discriminates between smooth muscle and neuronal P2X purinoceptors. (1995) (10)
- Breakdown of spatial coding and neural synchronization in epilepsy (2018) (10)
- Author response: CaImAn an open source tool for scalable calcium imaging data analysis (2018) (9)
- Local and CNS-Wide Astrocyte Intracellular Calcium Signaling Attenuation In Vivo with CalExflox Mice (2021) (9)
- ATP-gated P2X channels (2004) (9)
- A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear (2021) (9)
- GECIquant: Semi-automated Detection and Quantification of Astrocyte Intracellular Ca2+ Signals Monitored with GCaMP6f (2019) (7)
- Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain. (2018) (7)
- Lamina‐specific properties of spinal astrocytes (2021) (7)
- Retraction of astrocyte leaflets from the synapse enhances fear memory (2022) (7)
- Roles for P 2 X 4 receptor – mediated Imaging P 2 X 4 receptor subcellular distribution , trafficking , and regulation using P 2 X 4-pHluorin (2014) (6)
- Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice (2022) (5)
- Assessing Neuron–Astrocyte Spatial Interactions Using the Neuron–Astrocyte Proximity Assay (2020) (5)
- Molecular Time-Resolved Measurement of State-Specific P 2 X 2 Ion Channel Cytosolic Gating Motions (2004) (4)
- Slow Neuromodulation Mediated by ATP P2X Receptors (2014) (3)
- Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium (2016) (3)
- Cell-specific RNA purification to study translatomes of mouse central nervous system (2022) (3)
- Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents (2022) (3)
- Proximity of astrocyte leaflets to the synapse determines memory strength (2022) (2)
- Astrocytes amplify cerebral blood flow elevation to sustained cortical activation in the awake mouse (2020) (2)
- Neuronal and astrocytic contributions to Huntington's disease dissected with zinc finger protein transcriptional repressors. (2023) (2)
- Coordination of Escape and Spatial Navigation Circuits Orchestrate Versatile Flight from Threats (2020) (2)
- Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity (2020) (2)
- A Fast Genetically Encoded Fluorescent Sensor for Faithful in vivo Acetylcholine Detection in Mice, Fish, Worms and Flies (2020) (2)
- SnapShot: Astrocyte interactions (2022) (2)
- THE DOUBLE LIFEOF ATP (2009) (1)
- P2X receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database (2020) (1)
- Molecular and functional properties of PFC astrocytes during neuroinflammation-induced anhedonia (2020) (1)
- Huntington's Disease: Therapeutic strategy to reduce mutant huntingtin protein (2019) (0)
- A genetic approach to optically investigate P2X2 receptor activation in vivo using an activity‐dependent FRET based reporter tag (2010) (0)
- Title Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system (2013) (0)
- AnAngstromScaleInteractionbetweenPlasmaMembrane ATP-GatedP2X 2 and 42 NicotinicChannelsMeasured withFluorescenceResonanceEnergyTransferandTotal InternalReflectionFluorescenceMicroscopy (2005) (0)
- Breakdown of spatial coding and interneuron synchronization in epileptic mice (2020) (0)
- Cell morphology: Astrocyte structure at the nanoscale (2023) (0)
- Substituted cysteine accessibility mutagenesis of P2X2 receptors suggests the position of the gate with structural implications for closed‐open transitions (2010) (0)
- On the role of ATP at hippocampal inhibitory synapses and circuits (2003) (0)
- Reviewing Editors (2016) (0)
- P2X receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
- Stress gates an astrocytic energy reservoir to impair synaptic plasticity (2020) (0)
- Improved tools to study astrocytes (2020) (0)
- Dynamic Selectivity Filters Review in Ion Channels (1999) (0)
- Astrocytic contributions to Huntington's disease pathophysiology (2023) (0)
- Paper alert: Pharmacology (2001) (0)
- Methods and Approaches (2021) (0)
- Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms (2023) (0)
- Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity (2020) (0)
- All the light that we can see: a new era in miniaturized microscopy (2018) (0)
- Measuring mobility of ATP‐gated P2X channels in the plasma membrane (2008) (0)
- Oligodendrocyte calcium signaling sculpts myelin sheath morphology (2023) (0)
- A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP (2019) (0)
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