Barbara K. Felber
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American biologist
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Biology
Barbara K. Felber's Degrees
- PhD Biology University of California, Berkeley
- Masters Biology Stanford University
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Why Is Barbara K. Felber Influential?
(Suggest an Edit or Addition)According to Wikipedia, Barbara K. Felber is an American biologist specialized in human retrovirus pathogenesis and gene regulation. She is a senior investigator in the vaccine branch at the National Cancer Institute. Education Felber completed a Ph.D. in molecular biology from the University of Bern. She was a postdoctoral researcher in the laboratory of biochemistry at the National Cancer Institute.
Barbara K. Felber's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. (1989) (608)
- TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. (1998) (588)
- The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. (1985) (471)
- Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1 (1990) (442)
- The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region (1989) (354)
- Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression (1992) (282)
- Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein (1992) (281)
- Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation (1997) (270)
- Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs (1990) (262)
- Efficient production and enhanced tumor delivery of engineered extracellular vesicles. (2016) (237)
- The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs (1992) (226)
- Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I (1992) (221)
- Expression and characterization of the trans-activator of HTLV-III/LAV virus. (1986) (221)
- Effect of Plasmid DNA Vaccine Design and In Vivo Electroporation on the Resulting Vaccine-Specific Immune Responses in Rhesus Macaques (2007) (210)
- Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes (1994) (194)
- Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help3 (2005) (184)
- The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export (1997) (180)
- Containment of Simian Immunodeficiency Virus Infection in Vaccinated Macaques: Correlation with the Magnitude of Virus-Specific Pre- and Postchallenge CD4+ and CD8+ T Cell Responses1 (2002) (171)
- A quantitative bioassay for HIV-1 based on trans-activation. (1988) (169)
- Nucleoporins Nup98 and Nup214 Participate in Nuclear Export of Human Immunodeficiency Virus Type 1 Rev (1999) (167)
- Mosaic Vaccines Elicit CD8+ T lymphocyte Responses in Monkeys that Confer Enhanced Immune Coverage of Diverse HIV Strains (2010) (163)
- Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum. (2012) (162)
- Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer. (1986) (160)
- Intracellular Interaction of Interleukin-15 with Its Receptor α during Production Leads to Mutual Stabilization and Increased Bioactivity* (2008) (146)
- Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs (1992) (145)
- Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein (1990) (139)
- Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice. (2014) (135)
- Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA (1994) (128)
- Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function (1995) (127)
- CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control (2012) (127)
- PSF Acts through the Human Immunodeficiency Virus Type 1 mRNA Instability Elements To Regulate Virus Expression (2003) (123)
- Duplicated heavy metal control sequences of the mouse metallothionein-I gene. (1984) (121)
- Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells. (1990) (121)
- Identification of Novel Import and Export Signals of Human TAP, the Protein That Binds to the Constitutive Transport Element of the Type D Retrovirus mRNAs (1999) (121)
- Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection1 (2009) (119)
- Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection (2015) (119)
- The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function (1996) (118)
- A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteins (1990) (113)
- Potentiation of Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cell Responses by a DNA-SIV and NYVAC-SIV Prime/Boost Regimen (2001) (109)
- Expression of human immunodeficiency virus type 1 vif and vpr mRNAs is Rev-dependent and regulated by splicing. (1991) (108)
- SIV DNA vaccine co‐administered with IL‐12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques (2005) (106)
- The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. (2000) (103)
- Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation. (2008) (99)
- DNA Vaccines Expressing Different Forms of Simian Immunodeficiency Virus Antigens Decrease Viremia upon SIVmac251 Challenge (2005) (97)
- Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid (2007) (95)
- Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients (2021) (93)
- Evaluation of Novel Human Immunodeficiency Virus Type 1 Gag DNA Vaccines for Protein Expression in Mammalian Cells and Induction of Immune Responses (1999) (90)
- Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T Cell Sensitization, Tumor-Specific CTL Reactivity and Complete Regression of Disseminated Neuroblastoma Metastases in the Liver and Bone Marrow1 (2009) (89)
- Efficient expression of the human papillomavirus type 16 L1 protein in epithelial cells by using Rev and the Rev-responsive element of human immunodeficiency virus or the cis-acting transactivation element of simian retrovirus type 1 (1995) (87)
- Abnormal RNA splicing causes one form of α thalassemia (1982) (86)
- Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes (2018) (86)
- Therapeutic Vaccination with Simian Immunodeficiency Virus (SIV)-DNA+IL-12 or IL-15 Induces Distinct CD8 Memory Subsets in SIV-Infected Macaques1 (2008) (85)
- Characterization and Favorable in Vivo Properties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer* (2013) (84)
- A bioassay for HIV-1 based on Env-CD4 interaction. (1990) (83)
- A dose sparing effect by plasmid encoded IL-12 adjuvant on a SIVgag-plasmid DNA vaccine in rhesus macaques. (2006) (82)
- Competition for cellular factors that activate metallothionein gene transcription (1984) (79)
- The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene. (1987) (79)
- A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques (2015) (77)
- DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge (2013) (76)
- In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated (1983) (74)
- Enhanced Control of Pathogenic Simian Immunodeficiency Virus SIVmac239 Replication in Macaques Immunized with an Interleukin-12 Plasmid and a DNA Prime-Viral Vector Boost Vaccine Regimen (2011) (72)
- Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines. (2008) (72)
- Improved Vaccine Protection from Simian AIDS by the Addition of Nonstructural Simian Immunodeficiency Virus Genes1 (2006) (72)
- Expression and characterization of proteins produced by mRNAs spliced into the X region of the human T-cell leukemia/lymphotropic virus type II. (1995) (71)
- Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of T cells (1995) (70)
- Regulation of expression of human immunodeficiency virus. (1990) (70)
- Cross-activation of the Rex proteins of HTLV-I and BLV and of the Rev protein of HIV-1 and nonreciprocal interactions with their RNA responsive elements. (1989) (69)
- Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines. (1989) (68)
- U2AF Participates in the Binding of TAP (NXF1) to mRNA* (2002) (67)
- DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge (2009) (66)
- IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques (2012) (66)
- SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses. (2012) (65)
- Mutations in the Nuclear Export Signal of Human Ran-binding Protein RanBP1 Block the Rev-mediated Posttranscriptional Regulation of Human Immunodeficiency Virus Type 1* (1997) (64)
- Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization. (2010) (64)
- HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques. (2013) (64)
- The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit (2013) (63)
- Splicing variability in HIV type 1 revealed by quantitative RNA polymerase chain reaction. (1994) (63)
- RNA-binding Motif Protein 15 Binds to the RNA Transport Element RTE and Provides a Direct Link to the NXF1 Export Pathway* (2006) (61)
- Protection Afforded by an HIV Vaccine Candidate in Macaques Depends on the Dose of SIVmac251 at Challenge Exposure (2013) (61)
- Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model. (2004) (61)
- Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. (2007) (60)
- Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1 (1997) (59)
- Different sites of interaction for Rev, Tev, and Rex proteins within the Rev-responsive element of human immunodeficiency virus type 1 (1990) (58)
- Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes (2018) (56)
- Nuclear Export Factor Family Protein Participates in Cytoplasmic mRNA Trafficking* (2005) (52)
- Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA (2009) (52)
- Identification of a Novel Posttranscriptional Regulatory Element by Using a rev- and RRE-Mutated Human Immunodeficiency Virus Type 1 DNA Proviral Clone as a Molecular Trap (2001) (51)
- HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition (2018) (51)
- Secretion and Biological Activity of Short Signal Peptide IL-15 Is Chaperoned by IL-15 Receptor Alpha In Vivo1 (2009) (50)
- The Rex regulatory protein of human T-cell lymphotropic virus type I binds specifically to its target site within the viral RNA. (1991) (49)
- Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques (2014) (49)
- Long-Lasting Decrease in Viremia in Macaques Chronically Infected with Simian Immunodeficiency Virus SIVmac251 after Therapeutic DNA Immunization (2006) (47)
- The RNA-binding Motif Protein 15B (RBM15B/OTT3) Acts as Cofactor of the Nuclear Export Receptor NXF1* (2009) (46)
- SARS-CoV-2 antibody kinetics eight months from COVID-19 onset: Persistence of spike antibodies but loss of neutralizing antibodies in 24% of convalescent plasma donors (2021) (46)
- Molecular biology of HIV-1: positive and negative regulatory elements important for virus expression. (1993) (46)
- Kaposi's Sarcoma-Associated Herpesvirus ORF57 Interacts with Cellular RNA Export Cofactors RBM15 and OTT3 To Promote Expression of Viral ORF59 (2010) (46)
- Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10 (2020) (45)
- Inhibition of Rev-mediated HIV-1 expression by an RNA binding protein encoded by the interferon-inducible 9-27 gene. (1993) (44)
- DNA and Protein Co-Immunization Improves the Magnitude and Longevity of Humoral Immune Responses in Macaques (2014) (44)
- Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates (2015) (44)
- HIV-1 p24gag Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice (2013) (43)
- Mutational analysis of human prothymosin α reveals a bipartite nuclear localization signal (1997) (43)
- Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector. (2007) (42)
- Analysis of human immunodeficiency virus type 1 mRNA splicing patterns during disease progression in peripheral blood mononuclear cells from infected individuals. (1996) (41)
- Activation of tat-defective human immunodeficiency virus by ultraviolet light. (1990) (39)
- Anti–SARS-CoV-2 Antibody Responses in Convalescent Plasma Donors Are Increased in Hospitalized Patients; Subanalyses of a Phase 2 Clinical Study (2020) (38)
- Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit. (2010) (38)
- Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost (2015) (37)
- Efficient systemic expression of bioactive IL-15 in mice upon delivery of optimized DNA expression plasmids. (2007) (37)
- HIV DNA Vaccine: Stepwise Improvements Make a Difference (2014) (37)
- Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones in Rhesus Macaques during Acute Infection (2009) (36)
- HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques (2014) (35)
- Identification and characterization of the mouse nuclear export factor (Nxf) family members (2005) (34)
- Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors. (2005) (34)
- Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques. (2011) (32)
- Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice. (2006) (31)
- Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA. (1990) (31)
- Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques (2018) (30)
- Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques. (2003) (29)
- DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV (2016) (29)
- Sulfonic Acid Dyes: Inhibition of the Human Immunodeficiency Virus and Mechanism of Action (1992) (29)
- Preclinical evaluation of HIV-1 therapeutic ex vivo dendritic cell vaccines expressing consensus Gag antigens and conserved Gag epitopes. (2011) (29)
- Production of avian leukosis virus particles in mammalian cells can be mediated by the interaction of the human immunodeficiency virus protein Rev and the Rev-responsive element. (1995) (29)
- Posttranscriptional control of HIV-1 and other retroviruses and its practical applications. (2007) (28)
- An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element. (2002) (27)
- Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques (2013) (27)
- Isolation and translation in vitro of four related vitellogenin mRNAs of estrogen-stimulated Xenopus laevis. (1980) (27)
- Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge. (2020) (27)
- Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion (2016) (26)
- The RNA Transport Element of the Murine musD Retrotransposon Requires Long-range Intramolecular Interactions for Function* (2010) (25)
- Structural and Functional Analysis of the RNA Transport Element, a Member of an Extensive Family Present in the Mouse Genome (2005) (25)
- RTE and CTE mRNA export elements synergistically increase expression of unstable, Rev-dependent HIV and SIV mRNAs (2006) (25)
- Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques. (2014) (25)
- Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection (2018) (24)
- Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation (2016) (24)
- Estrogen induces tissue specific changes in the chromatin conformation of the vitellogenin genes in Xenopus. (1981) (24)
- Replacement of posttranscriptional regulation in SIVmac239 generated a Rev-independent infectious virus able to propagate in rhesus peripheral blood mononuclear cells. (1997) (24)
- Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells (2014) (23)
- Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa. (2011) (23)
- Retroviral Constitutive Transport Element Evolved from Cellular TAP(NXF1)-Binding Sequences (2001) (22)
- Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses. (2008) (22)
- Emergence of Simian Immunodeficiency Virus-Specific Cytotoxic CD4+ T Cells and Increased Humoral Responses Correlate with Control of Rebounding Viremia in CD8-Depleted Macaques Infected with Rev-Independent Live-Attenuated Simian Immunodeficiency Virus (2010) (22)
- Immunogenicity testing of a novel engineered HIV-1 envelope gp140 DNA vaccine construct. (2006) (22)
- Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses. (2014) (21)
- Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques (2018) (20)
- Inflammatory polyarthropathy and bone remodeling in HTLV-I Tax-transgenic mice. (1997) (19)
- Rev-Independent Simian Immunodeficiency Virus Strains Are Nonpathogenic in Neonatal Macaques (2002) (19)
- Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes (2009) (19)
- Neutrophil Vaccination Dynamics and Their Capacity To Mediate B Cell Help in Rhesus Macaques (2018) (19)
- Estradiol-induced accumulation of vitellogenin mRNA and secretion of vitellogenin in liver cultures of Xenopus (1978) (18)
- Unusual CD4+CD8+ phenotype in a greek patient diagnosed with adult T-cell leukemia positive for human T-cell leukemia virus type I (HTLV-I). (2000) (18)
- Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity (2019) (18)
- HIV Env conserved element DNA vaccine alters immunodominance in macaques (2017) (18)
- Mutational analysis of human prothymosin alpha reveals a bipartite nuclear localization signal. (1997) (18)
- Sequential Analysis of Binding and Neutralizing Antibody in COVID-19 Convalescent Patients at 14 Months After SARS-CoV-2 Infection (2021) (18)
- Modulation of Interleukin-12 activity in the presence of heparin (2017) (17)
- Differential effects of IL-15 on the generation, maintenance and cytotoxic potential of adaptive cellular responses induced by DNA vaccination. (2015) (17)
- Efficient production and purification of recombinant human interleukin-12 (IL-12) overexpressed in mammalian cells without affinity tag. (2014) (16)
- Kaposi's Sarcoma-Associated Herpesvirus ORF57 Is Not a Bona Fide Export Factor (2012) (16)
- Reduced viral load and lack of CD4 depletion in SCID-hu mice infected with Rev-independent clones of human immunodeficiency virus type 1 (1997) (16)
- Heterodimeric IL-15 in Cancer Immunotherapy (2021) (16)
- Quantitation of DNase I sensitivity in Xenopus chromatin containing active and inactive globin, albumin and vitellogenin genes. (1981) (14)
- Live attenuated rubella vectors expressing SIV and HIV vaccine antigens replicate and elicit durable immune responses in rhesus macaques (2013) (14)
- Rev of human immunodeficiency virus and Rex of the human T-cell leukemia virus type I can counteract an mRNA downregulatory element of the transferrin receptor mRNA. (1994) (13)
- Persistent Infection of Rhesus Macaques by the Rev-Independent Nef(−) Simian Immunodeficiency Virus SIVmac239: Replication Kinetics and Genomic Stability (1999) (13)
- Expression of human immunodeficiency virus long terminal repeat in the human promonocyte cell line U937: effect of endotoxin and cytokines. (1990) (13)
- Vaccination with Vaxfectin® adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia (2013) (12)
- The RNA transport element RTE is essential for IAP LTR-retrotransposon mobility. (2008) (12)
- Distinct neutralization profile of spike variants by antibodies induced upon SARS‐CoV‐2 infection or vaccination (2021) (12)
- Early T Follicular Helper Cell Responses and Germinal Center Reactions Are Associated with Viremia Control in Immunized Rhesus Macaques (2018) (12)
- Posttranscriptional regulation by Rev protein of human immunodeficiency virus type 1 results in nonrandom nuclear localization of gag mRNA. (1997) (12)
- Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques (2018) (12)
- Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques (2015) (11)
- DNA vaccination by intradermal electroporation induces long-lasting immune responses in rhesus macaques (2014) (11)
- Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors (2021) (11)
- Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy (2021) (11)
- DNA is an efficient booster of dendritic cell-based vaccine (2015) (11)
- Gammaretrovirus mRNA expression is mediated by a novel, bipartite post-transcriptional regulatory element (2014) (10)
- Abnormal RNA splicing causes one form of alpha thalassemia. (1982) (10)
- 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one (2016) (10)
- Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. (2006) (9)
- Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates (2020) (9)
- Recombinant rubella vectors elicit SIV Gag-specific T cell responses with cytotoxic potential in rhesus macaques. (2015) (9)
- Low Spike Antibody Levels and Impaired BA.4/5 Neutralization in Patients with Multiple Myeloma or Waldenstrom’s Macroglobulinemia after BNT162b2 Booster Vaccination (2022) (9)
- Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Protein co-immunization in rhesus macaques (2021) (9)
- A new step towards an HIV/AIDS vaccine (2018) (9)
- A Phase II Study on the Use of Convalescent Plasma for the Treatment of Severe COVID-19- A Propensity Score-Matched Control Analysis (2021) (9)
- Refined methods for propagating vesicular stomatitis virus vectors that are defective for G protein expression. (2010) (8)
- Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques (2013) (8)
- DNA Vaccine–Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination (2018) (8)
- Improved flow-based method for HIV/SIV envelope-specific memory B-cell evaluation in rhesus macaques. (2014) (7)
- Kaposi ’ s Sarcoma-Associated Herpesvirus ORF 57 Interacts with Cellular RNA Export Cofactors RBM 15 and OTT 3 To Promote Expression of Viral ORF 59 † (2011) (7)
- A Prime/Boost Vaccine Regimen Alters the Rectal Microbiome and Impacts Immune Responses and Viremia Control Post-Simian Immunodeficiency Virus Infection in Male and Female Rhesus Macaques (2020) (6)
- Four different vitellogenin proteins of Xenopus identified by translation in vitro. (1980) (6)
- Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques (2022) (5)
- Inhibition of Rev-mediated HIV-1 expression. (1994) (5)
- Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes (2018) (4)
- HIV vaccine: better to start together? (2019) (4)
- Immunotherapy with DNA vaccine and live attenuated rubella/SIV gag vectors plus early ART can prevent SIVmac251 viral rebound in acutely infected rhesus macaques (2020) (4)
- Expression of complete SIV p27 Gag and HIV gp120 engineered outer domains targeted by broadly neutralizing antibodies in live rubella vectors. (2017) (4)
- Antibodies to gp120 and PD-1 Expression on Virus-Specific CD8+ T Cells in Protection from Simian AIDS (2013) (4)
- Structure, regulation and oncogenic mechanisms of HTLV-I and HTLV-II. (1992) (4)
- Unsung Hero Robert C. Gallo (2009) (4)
- Kinetics of Nucleocapsid, Spike and Neutralizing Antibodies, and Viral Load in Patients with Severe COVID-19 Treated with Convalescent Plasma (2021) (3)
- Priming with DNA Expressing Trimeric HIV V1V2 Alters the Immune Hierarchy Favoring the Development of V2-Specific Antibodies in Rhesus Macaques (2020) (3)
- Heterodimeric IL-15 regulates the differentiation and survival of different populations of memory T cells and the balance of effector and regulatory cells (2013) (2)
- DNA-MVA Prime-Boost Vaccine Eliciting T-Cell Specificities Associated with HIV-1 Control Is Highly Immunogenic in Mice and Breaks CTL Immunodominance (2013) (2)
- Control of Heterologous SIVsmE660 infection by DNA and Protein Co-immunization Regimens Combined with Different Toll-like Receptor-4 (TLR-4) Based Adjuvants in Macaques (2018) (2)
- Reduced Antibodies and Innate Cytokine Changes in SARS-CoV-2 BNT162b2 mRNA Vaccinated Transplant Patients With Hematological Malignancies (2022) (2)
- Abstract 3259: heterodimeric IL-15 monotherapy results in complete regression of EO771 murine breast tumors through cDC1-lymphocyte interactions and induction of antitumor immunity (2019) (2)
- DNA priming vaccination to induce T cell responses to subdominant conserved HIV epitopes (2020) (1)
- Assessing Antigen-Specific Cellular Immune Responses upon HIV /SIV Plasmid DNA Vaccination in the Nonhuman Primate Model. (2021) (1)
- Live attenuated rubella vectors expressing SIV and HIV vaccine antigens replicate and elicit durable immune responses in rhesus macaques (2013) (1)
- Bone Marrow Neuroblastoma Metastases in the Liver and and Complete Regression of Disseminated Sensitization , Tumor-Specific CTL Reactivity IL-27 and IL-2 : Enhancement of T Cell Immunologic and Therapeutic Synergy of and (2009) (1)
- Abstract LB-088: Heterodimeric IL-15 enhances tumor infiltration, persistence and effector functions of adoptively transferred tumor-specific T cells in the absence of lymphodepletion (2016) (1)
- Mechanisms Contributing to Control of Viremia (2005) (1)
- Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy (2021) (1)
- The “complex” RNA post-transcriptional element of a “simple” retrovirus (2015) (1)
- XBB.1.5 neutralizing antibodies upon bivalent COVID‐19 vaccination are similar to XBB but lower than BQ.1.1 (2023) (1)
- immunodeficiency virus type 1. spliced mRNA species of human Cloning and functional analysis of multiply (2013) (1)
- Expression Instability Elements To Regulate Virus Immunodeficiency Virus Type 1 mRNA PSF Acts through the Human (2003) (1)
- Preservation of a subset of SIV-specific central memory CD4+ T cells correlates with control of viremia in SIVmac251 infected macaques (2006) (1)
- Mechanism of Heterodimeric IL-15 in tumor reduction: Induction of myeloid-lymphoid cell interactions leads to IFN-γ dependent lymphocyte recruitment by dendritic cells into tumors (2020) (1)
- Abstract 2727: Heterodimeric IL-15 (hetIL-15) affects conventional dendritic cells and a distinct novel dendritic cell population in different mouse cancer models of breast and pancreatic cancer (2021) (1)
- Bioassays for the Detection of HIV-1 and Practical Applications (1990) (1)
- Systemic IL-15, IFN-γ and IP-10/CXCL10 Signature Associated With Effective Immune Response in BNT162b2 mRNA Vaccine Recipients (2021) (1)
- 34 Novel conserved element HIV/SIV DNA vaccines maximize breadth and magnitude of immune response (2016) (1)
- Regulation of Expression of HIV-1 by Viral Factors (1989) (0)
- A Novel T-cell Vaccine Eliciting T-cell Specificities Associated with Control of HIV-1 In Humans Is Highly Immunogenic in Mice and Macaques (2014) (0)
- Mucosal Delivery of IL‐27 Attenuates Murine Enterocolitis via T Cell‐Derived IL‐10: O‐29 (2012) (0)
- 170 Getting the Right Immune Response to HIV: Evaluation of Protective Immune Responses After Vaccination of Rhesus Macaques (2009) (0)
- Immune Competition of HIV Epitopes in Draining Lymph Nodes (2018) (0)
- 8: Heterodimeric IL-15 promotes tumor control through the regulation of the balance of effector and regulatory cells via an IL-2 deprivation mechanism (2014) (0)
- Simian Immunodeficiency Virus Genes AIDS by the Addition of Nonstructural Improved Vaccine Protection from Simian Franchini Pavlakis (2005) (0)
- Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes (2023) (0)
- This information is current as Subsets in SIV-Infected Macaques or IL-15 Induces Distinct CD8 Memory Immunodeficiency Virus (SIV)-DNA+IL-12 Therapeutic Vaccination with Simian (2013) (0)
- Improved expression and delivery of IL‐15 DNA vectors in combination with IL‐15 receptor alpha in mice and macaques provide a potent growth signal for NK and T cells (2008) (0)
- METHOD FOR ELIMINATING inhibitory / instability REGIONS OF mRNA (1993) (0)
- Comparison of pharmacokinetics and biological activity of two IL-15 heterodimeric forms in mice and macaques (P6356) (2013) (0)
- Simian Immunodeficiency Virus Genes AIDS by the Addition of Nonstructural Improved Vaccine Protection from Simian (2005) (0)
- Antibody Response to COVID-19 mRNA Vaccine in Patients with Multiple Myeloma and Waldenstrom's Macroglobulinemia after Primary Immunization and Booster: Reactivity to the Sars-Cov-2 WT Virus, Delta and Omicron Variants (2022) (0)
- Heterodimeric IL-15 regulates the balance of effector and regulatory cells, promoting anti-cancer tumor effects (CCR4P.213) (2015) (0)
- HIV persistence despite reservoir decay during combinatorial immunotherapy including therapeutic conserved elements (CE) DNA vaccination, αPD-1 therapy, GS-986 TLR7-agonism, and CCR5 gene-edited CD4 T cell infusion in rhesus macaques (2019) (0)
- Use of IL-15 to increase the output of thymus and to treat lymphopenia (2010) (0)
- P-B7 Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection (2016) (0)
- Use of heterodimeric IL-15 in immune therapeutic regimens against HIV-1 or SIV infection (VAC8P.1048) (2015) (0)
- 20: Heterodimeric IL-15 regulates the balance of effector and regulatory cells, favoring anti-tumor responses (2013) (0)
- T Cells in HIV Infection + CD 8 Death-1 and CD 57 with Ex Vivo Survival of Differential Association of Programmed (2009) (0)
- Heterodimeric IL 15 Treatment Enhances Tumor In fi ltration , Persistence , and Effector Functions of Adoptively Transferred Tumor-speci fi c T Cells in the Absence of Lymphodepletion Sinnie (2017) (0)
- Vaccine-induced temporal cross-talk between myeloid cells reduces the risk of SIVmac251 acquisition (2017) (0)
- G-109 Reverse vaccinology identified promising vaccine candidates focusing responses to relatively conserved regions associated with control of viremia (2014) (0)
- Prime / Boost Regimen Responses by a DNA-SIV and NYVAC-SIV T Cell + and CD 8 + Virus ( SIV )-Specific CD 4 Potentiation of Simian Immunodeficiency (2001) (0)
- P-E3 Systemic dissemination, including mucosal sites, of cellular immunity elicited by DNA vaccines delivered by intramuscular injection (2014) (0)
- hetIL-15 therapy results in tumor control by promoting tumor infiltration of CD8+ T cells with increased cytotoxic potential and decreased PD-1 expression. (2016) (0)
- Abstract 2441: hetIL-15 decreases tumor cell dissemination and colonization and synergizes with chemotherapy and surgery to cure murine 4T1 breast tumors (2022) (0)
- ID: 99: Identification, function and clinical development of the heterodimeric IL-15 cytokine (hetIL-15) (2015) (0)
- Powerful mucosal immune response in macaques (Macaca mulatta) in response to SIV gp96-Ig immunization (39.35) (2009) (0)
- Novel HIV DNA vaccine changes the immune hierarchy and elicits broad cytotoxic T cell responses targeting subdominant viral epitopes (2019) (0)
- Book of Abstracts SIXTEENTH INTERNATIONAL CONFERENCE Sunday, September 26 – Wednesday, September 29, 2010 Westfields Marriott, Chantilly, VA, USA LOGIN FOR THOMSON REUTERS CONGRESS REPORTS (2010) (0)
- Regression of murine breast tumors after hetIL-15 monotherapy correlates with a novel population of intratumoral dendritic cells, in addition to increased infiltration of T, NK and cDC1 cells (2020) (0)
- Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation (2015) (0)
- TheRexregulatory protein ofhumanT-cell Iymphotropic virus typeIbindsspecifically toitstarget site within theviral RNA (1991) (0)
- DNA and Protein Co-immunization Improves the Magnitude, Longevity, and Mucosal Dissemination of Immune Responses (2014) (0)
- B cell depletion alone or in combination with IL-15 or PD-1 blockade facilitates enhanced control of virus replication in SIV-infected rhesus macaques (2019) (0)
- e-Blood Circulating IL-15 exists as heterodimeric complex with soluble IL-15 R in human and mouse serum (2012) (0)
- Modulation of Interleukin-12 activity in the presence of heparin (2017) (0)
- hetIL-15 treatment of rhesus macaques is safe and systemically increases effector cytotoxic lymphocytes that infiltrate the lymph nodes. (2017) (0)
- PL4-4 Heterodimeric IL-15/IL-15Rα accelerates immune reconstitution in lymphopenic mice (2010) (0)
- Abstract 6651: Combination of hetIL-15 with chemotherapy in triple negative breast and pancreatic cancer mouse models increases tumor necrosis and alleviates metastatic disease (2020) (0)
- Live attenuated rubella vectors expressing Plasmodium falciparum circumsporozoite protein (Pf-CSP) provide a novel malaria vaccine platform in the rhesus macaque. (2021) (0)
- Live attenuated viral vectors based on the rubella vaccine strain RA27/3 (2021) (0)
- CD 8 + Virus-Specific Pre-and Postchallenge CD 4 Correlation with the Magnitude of Virus Infection in Vaccinated Macaques : Containment of Simian Immunodeficiency (2002) (0)
- Abstract 5082: Heterodimeric IL-15 (hetIL-15) immunotherapy synergizes with Fatty Acid Metabolism Modulator (FAMM) to eradicate TNBC EO771 murine tumors (2023) (0)
- Abstract 5545: Heterodimeric interleukin 15 (hetIL-15) treatment decreases primary breast cancer 4T1 tumors and alleviates the metastatic burden (2018) (0)
- 224 Persistent virological benefit in SIV-infected macaques upon therapeutic vaccination with DNA vectors by in vivo constant-current electroporation (2009) (0)
- INFLAMMATORY POLYARTHRITIS AND BONE REABSORPTION IN TAX-TRANSGENIC MICE (1995) (0)
- Molecular Interaction of HIV-1 in Glioma Cells (1995) (0)
- Mucosal Delivery of IL‐27 Attenuates Murine Enterocolitis via T Cell‐Derived IL‐10: P‐176 (2012) (0)
- RBM 15 Binds to the RNA Transport Element RTE and Provides a Direct Link to the NXF 1 Export Pathway (2006) (0)
- Book of Abstracts - Sixteenth International Conference of the Inflammation Research Association, Sunday, September 26 – Wednesday, September 29, 2010 Westfields Marriott, Chantilly, VA, USA (2010) (0)
- HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition (2018) (0)
- Modulation of DNA/ALVAC/gp120 vaccine immune-response by vaccination with Insulin-Like Growth Factor 1 (IGF-1) (2017) (0)
- IL-15 Receptor alpha increases the stability and promotes secretion and bioactivity of the short signal peptide variant of IL-15 (38.3) (2009) (0)
- Immunodeficiency Virus Rev-Independent Live-Attenuated Simian CD8-Depleted Macaques Infected with Control of Rebounding Viremia in with Increased Humoral Responses Correlate T Cells and + Virus-Specific Cytotoxic CD4 Emergence of Simian Immunodeficiency (2010) (0)
- Pharmacokinetics and immunological effects of human IL-15/IL-15Rα heterodimeric complexes in macaques and comparison to single-chain IL-15 (P6242) (2013) (0)
- PS1-27 Lactococcus lactis expressing IL-27: A potential therapeutic for inflammatory bowel disease (2010) (0)
- Supraphysiological levels of IL-15 accelerate immune reconstitution in lymphopenic mice (134.16) (2010) (0)
- A-112 DNA and Protein Co-immunization Improves the Magnitude, Longevity, and mucosal dissemination of Immune Responses (2014) (0)
- Biochemical Characterization of Human IL-15 Receptor-alpha. (2013) (0)
- A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques (2015) (0)
- Abstract 5694: Complete regression of murine breast tumors by hetIL-15FC monotherapy correlates with infiltration by T, NK, cDC1 cells and a novel population of dendritic cells (2020) (0)
- Efficient ex vivo expansion of conserved element vaccine-specific CD8+ T-cells from SHIV-infected, ART-suppressed nonhuman primates (2023) (0)
- Abstract 5603: Heterodimeric IL-15 (hetIL-15) immunotherapy reverses CD8+T cell metabolic dysfunction in murine breast tumors (2022) (0)
- E112 Comparison of systemic and mucosal responses after DNA and protein co-immunization (2013) (0)
- P-D11 Live attenuated rubella/gag vectors elicit potent antibody and T cell responses that may change the course of SIV infection in macaques (2017) (0)
- 575 Regression by hetIL-15 monotherapy in different mouse breast cancer models correlates with intratumoral infiltration of a novel population of dendritic cells (2020) (0)
- SS1-1 Lactococcus lactis expressing IL-27: Therapeutic promise in inflammatory bowel disease (2010) (0)
- Antibodies to gp120 and PD-1 Expression on Virus-Specific CD8 (cid:1) T Cells in Protection from Simian AIDS (2013) (0)
- Live attenuated rubella vectors express HIV Env and SIV Gag antigens in the context of an acute infection and elicit high antibody titers, memory B cells, and Gag specific CD8+ T cells (VIR5P.1033) (2014) (0)
- Posttranscriptional Control: A General and Important Regulatory Feature of HIV-1 and Other Retroviruses (2018) (0)
- Erratum to “Use of interleukin 15 to enhance interferon-γ production by antigen-specific stimulated lymphocytes from rhesus macaques” [J. Immunol. Methods (279) (2003) 55–67] (2009) (0)
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