Barbara Ramsay Shaw
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American chemist
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Chemistry
Barbara Ramsay Shaw's Degrees
- Masters Chemical Engineering Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Barbara Ramsay Shaw Influential?
(Suggest an Edit or Addition)According to Wikipedia, Barbara Ramsay Shaw is the William T. Miller Distinguished Emeritus Professor of Chemistry at Duke University. She is known for her work on how DNA reacts with other compounds. Education and career Shaw earned her B.A. from Bryn Mawr College in 1965. She has an M.S. and a Ph.D. in physical chemistry from the University of Washington. Her Ph.D. advisors were Michael Schurr, professor of chemistry at the University of Washington and Walter Kauzmann, professor of chemistry and member of the National Academy of Sciences at Princeton University. Shaw received her post-doctoral training from Kensal van Holde, professor of biochemistry and member of the National Academy of Sciences at Oregon State University. In 1975 Shaw moved to Duke University as an assistant professor, and by 1992 she had been promoted to full professor. In 2006 Shaw was named the William T Miller Distinguished Professor of Chemistry at Duke University.
Barbara Ramsay Shaw's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. (1990) (471)
- Conjugates of Antisense Oligonucleotides with the Tat and Antennapedia Cell-Penetrating Peptides: Effects on Cellular Uptake, Binding to Target Sequences, and Biologic Actions (2004) (265)
- Analysis of subunit organization in chicken erythrocyte chromatin. (1976) (179)
- Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. (2000) (162)
- A model for particulate structure in chromatin. (1974) (144)
- Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking. (1982) (132)
- Boron-containing nucleic acids. 2. Synthesis of oligodeoxynucleoside boranophosphates (1990) (123)
- Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions. (1996) (118)
- Nucleoside and oligonucleoside boranophosphates: chemistry and properties. (2007) (102)
- High potency silencing by single-stranded boranophosphate siRNA (2006) (98)
- Base stacking and molecular polarizability: effect of a methyl group in the 5-position of pyrimidines. (1987) (91)
- DNA base modification: ionized base pairs and mutagenesis. (1987) (86)
- Cytosine deamination in mismatched base pairs. (1993) (83)
- Electron microscopy of chromatin subunit particles. (1974) (76)
- Chromatographic separation of chromatin subunits. (1974) (67)
- Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine. (1987) (65)
- Evaluating the Specificity of Antisense Oligonucleotide Conjugates (2002) (64)
- H-PHOSPHONATE APPROACH FOR SOLID-PHASE SYNTHESIS OF OLIGODEOXYRIBONUCLEOSIDE BORANOPHOSPHATES AND THEIR CHARACTERIZATION (1998) (63)
- Boron-containing aptamers to ATP. (2002) (60)
- Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. (2012) (59)
- 5′‐P‐Borane‐Substituted Thymidine Monophosphate and Triphosphate (1992) (54)
- Reading, Writing, and Modulating Genetic Information with Boranophosphate Mimics of Nucleotides, DNA, and RNA (2003) (53)
- Direct PCR sequencing with boronated nucleotides. (1997) (52)
- Boranophosphates support the RNase H cleavage of polyribonucleotides. (1999) (49)
- Boranophosphate backbone: a mimic of phosphodiesters, phosphorothioates, and methyl phosphonates. (2000) (47)
- Dimers, trimers, and tetramers of cytosine with guanine (1989) (46)
- Boranophosphates as mimics of natural phosphodiesters in DNA. (2001) (45)
- Boron-containing nucleic acids. Synthesis of cyanoborane adducts of 2'-deoxynucleosides (1989) (42)
- The hydrogen bonding of cytosine with guanine: Calorimetric and 1H‐NMR analysis of the molecular interactions of nucleic acid bases (1987) (40)
- Boron-containing oligodeoxyribonucleotide 14mer duplexes: enzymatic synthesis and melting studies. (1995) (40)
- Shift in nucleosome populations during embryogenesis: microheterogeneity in nucleosomes during development of the sea urchin embryo. (1981) (40)
- Synthesis and Separation of Diastereomers of Ribonucleoside 5'-(alpha-P-Borano)triphosphates. (1998) (39)
- Levels of histone H4 diacetylation decrease dramatically during sea urchin embryonic development and correlate with cell doubling rate. (1984) (35)
- From boron analogues of amino acids to boronated DNA: potential new pharmaceuticals and neutron capture agents (1991) (34)
- Synthesis of 5-substituted 2'-deoxycytidine 5'-(alpha-P-borano)triphosphates, their incorporationinto DNA and effects on exonuclease. (1999) (33)
- Hydrolysis of Thymidine Boranomonophosphate and Stepwise Deuterium Substitution of the Borane Hydrogens. 31P and 11B NMR Studies (1996) (29)
- In a model cytosine:guanine base pair, one amino group rotates and the other does not (1990) (28)
- The association reaction of collagen model polypeptides (Pro‐Pro‐Gly)n (1975) (28)
- In vitro transport and delivery of antisense oligonucleotides. (2000) (27)
- Kinetics of bisulfite-induced cytosine deamination in single-stranded DNA. (1993) (26)
- Structural Studies of a Borane-Modified Phosphate Diester Linkage: Ab Initio Calculations on the Dimethylboranophosphate Anion and the Single-Crystal X-ray Structure of Its Diisopropylammonium Salt. (1998) (26)
- Bisulfite Induces Tandem Double CC .fwdarw. TT Mutations in Double-Stranded DNA. 2. Kinetics of Cytosine Deamination (1994) (26)
- Synthesis of α-P-Modified Nucleoside Diphosphates with Ethylenediamine (2005) (26)
- Deamination of single-stranded DNA cytosine residues in aerobic nitric oxide solution at micromolar total NO exposures. (1996) (25)
- Quasielastic light scattering by biopolymers. Conformation of chromatin multimers. (1976) (25)
- Antineoplastic activity of boron-containing thymidine nucleosides in Tmolt3 leukemic cells. (1992) (25)
- Boron Containing Nucleic Acids (1992) (24)
- Hydrolysis of N3-methyl-2'-deoxycytidine: model compound for reactivity of protonated cytosine residues in DNA. (1989) (24)
- Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators. (2008) (24)
- BORANE-AMINE COMPLEXES - VERSATILE REAGENTS IN THE CHEMISTRY OF NUCLEIC ACIDS AND THEIR ANALOGS (2001) (24)
- Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. (1993) (23)
- A convenient synthesis of 2′-deoxyribonucleoside 5′-(α-P-borano)triphosphates (1998) (23)
- Oligonucleoside boranophosphate (borane phosphonate). (1993) (22)
- Boranophosphate Oligonucleotides: New Synthetic Approaches (1997) (22)
- Silver staining of histones in Triton-acid-urea gels. (1983) (21)
- The synthesis and antineoplastic activity of 2'-deoxy-nucleoside-cyanoboranes in murine and human culture cells. (1992) (21)
- Anti-inflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents. (1994) (19)
- DNA sequence recognition by the antitumor drug ditercalinium. (2002) (19)
- In situ protamine release: a versatile sample preparation method for the electrophoretic analysis of nuclear proteins on acid/urea-based gels. (1982) (19)
- Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate (1999) (18)
- Shortest nucleosomal repeat lengths during sea urchin development are found in two-cell embryos. (1983) (17)
- Conformational studies of dithymidine boranomonophosphate diastereoisomers. (1997) (17)
- Synthesis of Boron-Containing ADP and GDP Analogues: Nucleoside 5′-(P-Boranodiphosphates) (2000) (16)
- N7-cyanoborane-2'-deoxyguanosine 5'-triphosphate is a good substrate for DNA polymerase. (1995) (16)
- Rapid and Selective Reduction of Amide Group by Borane-Amine Complexes in Acyl Protected Nucleosides (2000) (16)
- Structural basis of the RNase H1 activity on stereo regular borano phosphonate DNA/RNA hybrids. (2011) (15)
- Synthesis of a novel triphosphate analogue: nucleoside α-P-borano, α-P-thiotriphosphate (2000) (14)
- Nucleoside and Oligonucleoside Boranophosphates: Chemistry and Properties (2008) (13)
- Incorporation of (α-P-Borano)-2′,3′-dideoxycytidine 5′-Triphosphate into DNA by Drug-Resistant MMLV Reverse Transcriptase and Taq DNA Polymerase (2003) (13)
- Synthesis of a boron analogue of glucose-conjugated nucleoside diphosphate: nucleoside α-P-boranodiphosphoglucose (2000) (13)
- RNase H Activation by Stereoregular Boranophosphate Oligonucleotide (2003) (12)
- Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate. (2002) (12)
- INCORPORATION OF RIBONUCLEOSIDE 5′-(α-P-BORANO)TRIPHOSPHATES INTO A 20-MER RNA BY T7 RNA POLYMERASE (2005) (12)
- Hydrodynamic evidence in support of spacer regions in chromatin. (1977) (12)
- Convenient synthesis of nucleoside borane diphosphate analogues: deoxy- and ribonucleoside 5'-P(alpha)-boranodiphosphates. (2004) (12)
- Synthesis of dithymidine boranophosphates via stereospecific boronation of H-phosphonate diesters and assignment of their configuration (1999) (12)
- Synthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids. (2005) (12)
- Isolation and characterization of chromatin subunits. (1978) (11)
- Individual Isomers of Dinucleoside Boranophosphates as Synthons for Incorporation into Oligonucleotides: Synthesis and Configurational Assignment (2000) (11)
- Introduction of the α-P-Borano-Group into Deoxynucleoside Triphosphates Increases Their Selectivity to HIV-1 Reverse Transcriptase Relative to DNA Polymerases (2003) (11)
- Bisulfite induces tandem double CC-->TT mutations in double-stranded DNA. 2. Kinetics of cytosine deamination. (1994) (10)
- Novel 3',5'-cyclic nucleotide analogue: adenosine 3',5'-cyclic boranomonophosphate. (2001) (10)
- Synthesis and Separation of Diastereomers of Ribonucleoside 5′‐(α‐P‐Borano)triphosphates. (1999) (9)
- Echinomycin, a bis-intercalating agent, induces C-->T mutations via cytosine deamination. (1993) (9)
- SYNTHESIS OF NEW CLASSES OF BORON-CONTAINING NUCLEOTIDES (2001) (9)
- Structural differences in the chromatin from compartmentalized cells of the sea urchin embryo: differential nuclease accessibility of micromere chromatin. (1981) (8)
- SYNTHESIS OF OLIGONUCLEOSIDE BORANOPHOSPHATES VIA AN H-PHOSPHONATE METHOD WITHOUT NUCLEOBASE PROTECTION (2001) (8)
- Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: exploring a potential strategy for mechanism-based HCV drug design. (2013) (8)
- Synthesis of alpha-P-modified nucleoside diphosphates with ethylenediamine. (2005) (8)
- Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide. (2002) (8)
- Chemical and Enzymatic Incorporation of Boron into DNA (1993) (8)
- Conformation of Polynucleosomes in Low Ionic Strength Solution (1979) (8)
- Variable temperature infrared spectroscopy of cytosine-guanine base pairs: tautomerism versus polarization. (1992) (8)
- Temporal changes in nucleosome populations during sea urchin early development (1984) (8)
- Base-boronated dinucleotides: synthesis and effect of N7-cyanoborane substitution on the base protons. (1996) (8)
- Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase. (2003) (8)
- Stereospecificity, substrate, and inhibitory properties of nucleoside diphosphate analogs for creatine and pyruvate kinases. (2008) (8)
- Histone modifications accompanying the onset of developmental commitment. (1987) (8)
- Synthesis and properties of (alpha-P-borano)-nucleoside 5'-triphosphate analogues as potential antiviral agents. (2008) (8)
- Boranophosphate Backbone: A Mimic of Phosphodiesters, Phosphorothioates, and Methylphosphonates (2000) (7)
- Studies on base-boronated oligonucleotides. 2 (1). Incompatibility of DMT and cyanoborane groups during oligonucleotide synthesis. (1997) (7)
- Synthesis of diuridine 3′,5′-boranophosphate: H-phosphonate approach (1999) (7)
- SYNTHESIS AND PROPERTIES OF NOVEL TRIPHOSPHATE ANALOGUES: RIBONUCLEOSIDE AND DEOXYRIBONUCLEOSIDE (α-P-BORANO, α-P-THIO)TRIPHOSPHATES (2001) (7)
- Diffusible factors are responsible for differences in nuclease sensitivity among chromatins originating from different cell types. (1984) (5)
- The synthesis and anti-neoplastic activity of N2-isobutyryl-2'-deoxyguanosine-N7-cyanoborane derivatives. (1992) (5)
- SYNTHESIS OF A NOVEL NUCLEIC ACID MIMIC: P-BORANOMETHYLPHOSPHONATE (2001) (5)
- Use of phosphorus ligand NMR probes to investigate electronic and second-sphere solvent effects in ligand substitution reactions at manganese(II) and manganese(III). (2005) (5)
- 2'-Deoxycytidine-N(3)-cyanoborane Monohydrate (1996) (5)
- THE EFFECT OF A SINGLE BORANOPHOSPHATE SUBSTITUTION WITH DEFINED CONFIGURATION ON THE THERMAL STABILTIY AND CONFORMATION OF A DNA DUPLEX (2005) (5)
- Boranophosphate nucleic acids--a versatile DNA backbone. (1999) (5)
- Synthesis and separation of diastereomers of uridine 2',3'-cyclic boranophosphate. (2001) (5)
- MODEL SYNTHESIS OF NUCLEOSIDE BORANOPHOSPHORAMIDATE WITH AMINO ACID FOR PRODRUG PURPOSE (2005) (4)
- Boranophosphate Oligonucleotides: New Synthetic Approaches. (1998) (4)
- Boronated Peptides and Nucleic Acid Components for Nct (1993) (4)
- 31P NMR probes of chemical dynamics: paramagnetic relaxation enhancement of the (1)H and (31)P NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes. (2001) (4)
- Preparation and Analysis of Core Particles and Nucleosomes: A Convenient Method for Studying the Protein Composition of Nucleosomes using Protamine-Release into Triton-Acid-Urea Gels (1979) (3)
- Synthesis and hydrolytic properties of thymidine boranomonophosphate (2013) (3)
- One-Pot Synthesis of an AZT Boranophosphate Conjugated with Tyrosine: A Potential Prodrug Candidate (2003) (3)
- Reading and writing genetic information with boranophosphate (borane phosphate) mimics of nucleotides, DNA, and RNA (2002) (3)
- AN HYPOTHESIS FOR THE MOLECULAR PATHOGENESIS OF HEXANE NEUROPATHY (1980) (2)
- SYNTHESIS OF 5-ETHYNYL-2′-DEOXYURIDINE-5′-BORANOMONO PHOSPHATE AS A POTENTIAL THYMIDYLATE SYNTHASE INHIBITOR (2005) (2)
- Versatility of borane nucleic acids mimics for coding, decoding and modulating genetic information. (2007) (2)
- Synthesis of Boron Analogues of Biomolecules as Potential New Pharmaceuticals (> 22 refs.) (1995) (2)
- Oligonucleotides Containing N7-Cyanoborane-2′-deoxyguanosine (1997) (1)
- Boron-Containing Nucleic Acids: Synthesis of Cyanoborane Adducts of 2′-Deoxynucleosides. (1990) (1)
- Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates. (2015) (1)
- NUCLEOPROTEIN CORE PARTICLES IN CHROMATIN SUBUNITS: EXISTENCE OF A COMPLEX OF EIGHT HISTONES AND 140 NUCLEOTIDE PAIRS OF DNA (1976) (1)
- Efficient Synthesis Of Thymidine Boranophosphoramidates Conjugated With Amino Acids (2007) (1)
- SYNTHESIS OF 5-(1-PROPYNYL)-2′-DEOXYURIDINE 5′-(ALPHA-P-BORANO)TRIPHOSPHATE AND KINETIC CHARACTERIZATION AS A SUBSTRATE FOR MMLV REVERSE TRANSCRIPTASE (2005) (1)
- AFFINITY OF (α-P-BORANO)-NTP ANALOGS TO RABBIT MUSCLE PYRUVATE KINASE (2005) (1)
- Phosphorus deprotonation by a non-nucleophilic base is critical for the synthesis of nucleoside α-P-boranodiphosphates via a phosphoramidite approach (2014) (1)
- Boron‐Containing Nucleic Acids. Part 3. 5′‐P‐Borane‐Substituted Thymidine Monophosphate and Triphosphate. (1993) (1)
- Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates (2015) (1)
- Synthesis and Properties of Novel Triphosphate Analogues: Ribonucleoside and Deoxyribonucleoside (α‐P‐Borano, α‐P‐Thio)triphosphates (2010) (0)
- Synthesis and Separation of Diastereomers of Uridine 2′,3′-Cyclic Boranophosphate. (2001) (0)
- Oligonucleotides Containing N7-Cyanoborane-2′-deoxyguanosine. (2010) (0)
- Dimers, Trimers, and Tetramers of Cytosine with Guanine. (1989) (0)
- Rapid and Selective Reduction of Amide Group by Borane—Amine Complexes in Acyl Protected Nucleosides. (2000) (0)
- Synthesis of Acyclothymidine Triphosphate and α-P-Boranotriphosphate and Their Substrate Properties with Retroviral Reverse Transcriptase. (2003) (0)
- Oligonucleoside Boranophosphate (Borane Phosphonate) (1994) (0)
- [One-step PCR sequencing]. Final report, July 1, 1994--August 31, 1997 (1997) (0)
- One-Step PCR Sequencing. Final Technical Progress Report for February 15, 1997 - November 30, 2001 (2004) (0)
- Synthesis of 9-Fluorenemethyl Boranophosphonodiphosphate Via an H-Phosphonate Approach (2007) (0)
- Protonated base pairs explain the a properties of 06-methylguanine (hydrogen bonding/DNA structure/protonated cytosine/mutagenesi (2016) (0)
- DNA / RNA Hybrid containing a central stereo specific Rp borano phosphate linkage (2011) (0)
- Boron-Containing Nucleic Acids. Part 2. Synthesis of Oligodeoxynucleoside Boranophosphates. (1991) (0)
- Oligoribonucleosides and oligodeoxyribonukleoside-boranophosphates (1990) (0)
- Borane—Amine Complexes — Versatile Reagents in the Chemistry of Nucleic Acids and Their Analogues (2001) (0)
- Base pairing properties of O/sup 6/-methylguanine (1986) (0)
- Novel 3′,5′‐Cyclic Nucleotide Analogue: Adenosine 3′,5′‐Cyclic Boranomonophosphate. (2001) (0)
- 2'-Deoxycytidine-N3-cyanoborane (1996) (0)
- Protonated base pairs explain the ambiguous pairing properties of 06-methylguanine ( hydrogen bonding / DNA structure / protonated cytosine / mutagenesis ) (2012) (0)
- nucleosides containing boron (1990) (0)
- Synthesis of a Boron Analogue of Glucose-Conjugated Nucleoside Diphosphate: Nucleoside α-P-Boranodiphosphoglucose. (2000) (0)
- Hydrolytic properties of thymidine a-P-boranophosphate analogs (2010) (0)
- Synthesis and Properties of a Novel Phosphodiester Analogue, Nucleoside Boranophosphorothioate. (1999) (0)
- Incorporation of (α‐P‐Borano)‐2′,3′‐dideoxycytidine 5′‐Triphosphate into DNA by Drug‐Resistant MMLV Reverse Transcriptase and Taq DNA Polymerase (2004) (0)
- Synthesis of a Novel Triphosphate Analogue: Nucleoside α-P-Borano, α-P-Thiotriphosphate. (2001) (0)
- Affinity of (alpha-P-borano)-NTP analogs to rabbit muscle pyruvate kinase. (2005) (0)
- Boron Analogues of Amino Acids and Derivatives (1989) (0)
- Procede de sequençage d'acides nucleiques (1994) (0)
- Synthesis of Nucleoside 3′,5′-Cyclic Boranophosphorothioate, a New Type of Cyclic Nucleotide. (2003) (0)
- Synthesis and properties of novel triphosphate analogues: ribonucleoside and deoxyribonucleoside (alpha-P-borano, alpha-P-thio)triphosphates. (2001) (0)
- Synthesis of New Classes of Boron‐Containing Nucleotides (2001) (0)
- One‐Pot Synthesis of an AZT Boranophosphate Conjugated with Tyrosine: A Potential Prodrug Candidate (2004) (0)
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