Bart Deplancke
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Why Is Bart Deplancke Influential?
(Suggest an Edit or Addition)According to Wikipedia, Bart Deplancke is a Belgian bio-engineer and researcher. He is a full professor at École Polytechnique Fédérale de Lausanne, where he leads the laboratory of systems biology and genetics. Career Deplancke studied biochemical engineering at Ghent University and graduated with a Master of Science in 1998. In 2002, he obtained a PhD in immunobiology from the University of Illinois at Urbana-Champaign for his studies on intestinal host-microbe interactions and innate immunity. He then pursued postdoctoral studies in the laboratories of Marc Vidal and Marian Walhout , where he developed a high-throughput protein-DNA interaction screening approach and worked on elucidating metazoan genetic regulatory networks. In 2007, he established his own lab at École Polytechnique Fédérale de Lausanne, where he was successively promoted to associate professor in 2014, and to full professor in 2020. He is currently vice-dean for innovation there. He is a cofounder of the Junior European Drosophila Investigators scientific network. Since 2013, Deplancke is a group leader at the Swiss Institute of Bioinformatics.
Bart Deplancke's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The Human Cell Atlas (2017) (1285)
- Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. (2001) (926)
- Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. (2011) (711)
- Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines (2014) (509)
- Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. (2013) (392)
- Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research. (2015) (362)
- Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription (2013) (338)
- The Genetics of Transcription Factor DNA Binding Variation (2016) (262)
- A stromal cell population that inhibits adipogenesis in mammalian fat depots (2018) (249)
- A Gene-Centered C. elegans Protein-DNA Interaction Network (2006) (241)
- Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans (2008) (238)
- A gateway-compatible yeast one-hybrid system. (2004) (229)
- Conservation of transcription factor binding specificities across 600 million years of bilateria evolution (2015) (222)
- Gene Regulatory Networks (2012) (208)
- Fermentation by gut microbiota cultured in a simulator of the human intestinal microbial ecosystem is improved by supplementing a soygerm powder. (2000) (203)
- A compendium of Caenhorabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks (2005) (197)
- Population Variation and Genetic Control of Modular Chromatin Architecture in Humans (2015) (192)
- A first version of the Caenorhabditis elegans Promoterome. (2004) (192)
- Molecular ecological analysis of porcine ileal microbiota responses to antimicrobial growth promoters. (2003) (191)
- Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles (2012) (191)
- Hydrogen sulfide induces serum‐independent cell cycle entry in nontransformed rat intestinal epithelial cells (2003) (175)
- Molecular Ecological Analysis of the Succession and Diversity of Sulfate-Reducing Bacteria in the Mouse Gastrointestinal Tract (2000) (149)
- Selective growth of mucolytic bacteria including Clostridium perfringens in a neonatal piglet model of total parenteral nutrition. (2002) (145)
- Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches (2021) (141)
- Roles of Vibrio fischeri and Nonsymbiotic Bacteria in the Dynamics of Mucus Secretion during Symbiont Colonization of the Euprymna scolopes Light Organ (2002) (134)
- Systematic dissection of genomic features determining transcription factor binding and enhancer function (2017) (132)
- C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO (2006) (127)
- Quantifying ChIP-seq data: a spiking method providing an internal reference for sample-to-sample normalization (2014) (127)
- Effects of Tylosin on Bacterial Mucolysis, Clostridium perfringens Colonization, and Intestinal Barrier Function in a Chick Model of Necrotic Enteritis (2003) (121)
- C. elegans tubby regulates life span and fat storage by two independent mechanisms. (2005) (117)
- Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster (2012) (113)
- Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly (2022) (111)
- The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. (2019) (109)
- Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit (2012) (108)
- GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer (2014) (108)
- Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium (2020) (97)
- Intestinal Transport of the Lactokinin Ala‐Leu‐Pro‐Met‐His‐Ile‐Arg through a Caco‐2 Bbe Monolayer (2002) (94)
- Complex expression dynamics and robustness in C. elegans insulin networks (2013) (92)
- ASAP: a web-based platform for the analysis and interactive visualization of single-cell RNA-seq data (2016) (91)
- Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. (2018) (89)
- Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPβ and KAISO. (2012) (86)
- Absolute quantification of transcription factors during cellular differentiation using multiplexed targeted proteomics (2013) (85)
- Automated protein-DNA interaction screening of Drosophila regulatory elements (2011) (82)
- BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing (2019) (82)
- SMiLE-seq identifies binding motifs of single and dimeric transcription factors (2017) (82)
- Gastrointestinal and Microbial Responses to Sulfate-Supplemented Drinking Water in Mice (2003) (81)
- Gateway-compatible yeast one-hybrid screens. (2006) (77)
- Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping (2007) (75)
- Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network (2014) (72)
- Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes (2016) (63)
- Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses (2020) (63)
- Redox control of the transsulfuration and glutathione biosynthesis pathways. (2002) (63)
- Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex (2011) (62)
- Transcriptional regulatory logic of the diurnal cycle in the mouse liver (2016) (60)
- Bayesian association scan reveals loci associated with human lifespan and linked biomarkers (2017) (60)
- Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence (2015) (56)
- An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement (2014) (54)
- Global and Stage Specific Patterns of Krüppel-Associated-Box Zinc Finger Protein Gene Expression in Murine Early Embryonic Cells (2013) (50)
- Genome-Wide Analysis of SREBP1 Activity around the Clock Reveals Its Combined Dependency on Nutrient and Circadian Signals (2014) (46)
- GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR (2011) (46)
- A Comprehensive Drosophila melanogaster Transcription Factor Interactome (2019) (46)
- The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors (2009) (44)
- Hippo, TGF-β, and Src-MAPK pathways regulate transcription of the upd3 cytokine in Drosophila enterocytes upon bacterial infection (2017) (43)
- Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle (2019) (42)
- A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development (2015) (40)
- PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator (2016) (40)
- Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity. (2020) (39)
- Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly (2021) (36)
- Primer-initiated sequence synthesis to detect and assemble structural variants (2010) (36)
- Live-seq enables temporal transcriptomic recording of single cells (2022) (36)
- A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks (2013) (32)
- Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons (2019) (28)
- A systems perspective on brown adipogenesis and metabolic activation (2017) (27)
- Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress (2020) (27)
- Transcription factor proteomics—Tools, applications, and challenges (2017) (27)
- iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks (2012) (27)
- Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells. (2017) (27)
- Cross-talk between emulsion drops: how are hydrophilic reagents transported across oil phases? (2018) (26)
- ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer (2019) (24)
- GETPrime 2.0: gene- and transcript-specific qPCR primers for 13 species including polymorphisms (2016) (24)
- GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer (2014) (23)
- Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models* (2016) (21)
- Dissecting the brown adipogenic regulatory network using integrative genomics (2017) (20)
- DNA-centered approaches to characterize regulatory protein-DNA interaction complexes. (2010) (20)
- Genomic analysis of European Drosophila melanogaster populations on a dense spatial scale reveals longitudinal population structure and continent-wide selection (2018) (19)
- Deterministic scRNA-seq captures variation in intestinal crypt and organoid composition (2022) (18)
- Simplified Drop-seq workflow with minimized bead loss using a bead capture and processing microfluidic chip. (2019) (16)
- Recent advances in trajectory inference from single-cell omics data (2021) (15)
- Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo (2020) (15)
- Experimental advances in the characterization of metazoan gene regulatory networks. (2008) (14)
- Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo. (2013) (14)
- The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression (2020) (13)
- The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms (2016) (13)
- Extensive tissue-specific expression variation and novel regulators underlying circadian behavior (2021) (12)
- Genomic analysis of European Drosophila populations reveals major longitudinal structure, continent-wide selection, and unknown DNA viruses (2018) (12)
- Potential Direct Regulators of the Drosophila yellow Gene Identified by Yeast One-Hybrid and RNAi Screens (2016) (12)
- ASAP 2020 update: an open, scalable and interactive web-based portal for (single-cell) omics analyses (2020) (11)
- A high-throughput gateway-compatible yeast one-hybrid screen to detect protein-DNA interactions. (2012) (11)
- The Zic family homologue Odd-paired regulates Alk expression in Drosophila (2017) (11)
- Author response: The Human Cell Atlas (2017) (10)
- Identification and removal of low-complexity sites in allele-specific analysis of ChIP-seq data (2014) (10)
- Tissue-specific enhancer repression through molecular integration of cell signaling inputs (2017) (10)
- Differential regulation of RNA polymerase III genes during liver regeneration (2018) (10)
- Profiling of Single‐Cell Transcriptomes (2017) (10)
- LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis (2021) (10)
- cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel (2020) (9)
- Gene regulatory networks : methods and protocols (2012) (9)
- Selective Retrieval of Individual Cells from Microfluidic Arrays Combining Dielectrophoretic Force and Directed Hydrodynamic Flow (2020) (9)
- Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress (2019) (9)
- Genome-wide molecular recording using Live-seq (2021) (8)
- The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. (2021) (8)
- Time- and cost-efficient high-throughput transcriptomics enabled by Bulk RNA Barcoding and sequencing (2018) (8)
- Genome-wide profiling of DNA-binding proteins using barcode-based multiplex Solexa sequencing. (2012) (8)
- Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning. (2019) (7)
- BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing (2019) (6)
- Cross‐Tissue Identification of Somatic Stem and Progenitor Cells Using a Single‐Cell RNA‐Sequencing Derived Gene Signature (2017) (6)
- Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection (2021) (6)
- Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel (2019) (5)
- WebPrInSeS: automated full-length clone sequence identification and verification using high-throughput sequencing data (2010) (5)
- Current challenges in understanding the role of enhancers in disease. (2022) (5)
- A mammalian transcription factor‐specific peptide repository for targeted proteomics (2015) (4)
- Multilevel regulation of the glass locus during Drosophila eye development (2019) (4)
- Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes (2020) (4)
- Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila (vol 3, pg 1725, 2013) (2013) (4)
- Sex‐dependent and sex‐independent regulatory systems of size variation in natural populations (2019) (4)
- Selection against expression noise explains the origin of the hourglass pattern of Evo-Devo (2019) (4)
- Multimodal and multisensory coding in the Drosophila larval peripheral gustatory center (2020) (3)
- ZFP 30 promotes adipogenesis through the KAP 1-mediated activation of a retrotransposon-derived Pparg 2 enhancer (2019) (3)
- Deterministic scRNA-seq of individual intestinal organoids reveals new subtypes and coexisting distinct stem cell pools (2020) (3)
- Gene regulatory mechanisms underlying the intestinal innate immune response. (2017) (3)
- Diverse cell-specific patterns of alternative polyadenylation in Drosophila (2022) (3)
- A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation (2022) (3)
- Pseudomonas aeruginosa contracts mucus to form biofilms in tissue-engineered human airways (2022) (3)
- Editorial overview: Genome architecture and expression. (2017) (3)
- A compendium of regulatory transcription factors: a resource for mapping transcription regulatory ne (2011) (3)
- Author response: Conservation of transcription factor binding specificities across 600 million years of bilateria evolution (2015) (3)
- An hourglass pattern of inter-embryo gene expression variability and of histone regulation in fly embryogenesis (2019) (2)
- A highly parallel, automated platform enabling individual or sequential ChIP of histone marks and transcription factors (2019) (2)
- Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2021) (2)
- A parallelized, automated platform enabling individual or sequential ChIP of histone marks and transcription factors (2020) (2)
- A first version of the Caenorhabditis elegans (2018) (2)
- Extensive mitochondrial population structure and haplotype-specific phenotypic variation in the Drosophila Genetic Reference Panel (2018) (2)
- Variable Outcome of Mutations (2012) (2)
- Mammalian adipogenesis regulators (Aregs) exhibit robust non- and anti-adipogenic properties that arise with age and involve retinoic acid signalling (2021) (1)
- A Gateway-Compatible Yeast One-Hybrid System Related Content (2004) (1)
- Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner (2022) (1)
- A stromal cell population that inhibits adipogenesis in mammalian fat depots (2018) (1)
- Chromatin modules and their implication in genomic organization and gene regulation. (2022) (1)
- Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo (2020) (1)
- Author response: Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network (2014) (1)
- SMiLE-seq: Selective Microfluidics-based Ligand Enrichment followed by sequencing (2017) (1)
- Data from: Identification of ZEB1 as a central component of the adipogenic gene regulatory network (2014) (1)
- LifeTime and improving European healthcare through cell-based interceptive medicine (2020) (1)
- Disease-Informed Bayesian Association Scan Reveals Novel Loci Associated with Human Lifespan and Linked Biomarkers (2017) (1)
- A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle (2022) (1)
- Gene expression ASAP : a web-based platform for the analysis and interactive visualization of single-cell RNA-seq data (2017) (0)
- ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer (2019) (0)
- Postnatal lymph node expansion of stromal progenitors towards reticular and CD34+ stromal cell subsets is determined by distinct transcriptional programs (2021) (0)
- Intestinal transport of ACE inhibitory peptides derived from food proteins, studied with Caco-2Bbe monolayer in an Ussing Chamber experiment (2001) (0)
- Shared acute phase traits in effector and memory human CD8 T cells (2021) (0)
- Author Correction: Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel (2020) (0)
- Pool-seq DrosEU 2014 samples VCF file (2019) (0)
- Web-based pipeline for the analysis and interactive visualization of single-cell RNAseq data (2016) (0)
- Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (2021) (0)
- Sulfate -Reducing Bacteria and Their Contribution to Intestinal Epithelial Disorders (2002) (0)
- Acknowledgment to reviewers 2018 (2018) (0)
- 2013 – A LABEL-FREE, HIGH-THROUGHPUT PHENOTYPIC SCREEN OF ADIPOCYTIC DIFFERENTIATION MODULATORS TO ACCELERATE HEMATOPOIETIC RECOVERY (2022) (0)
- Innate Antiviral Specialization of Ly6C+CD45+ Splenic Red Pulp Stroma Instilled by Subset-Specific Regulation of Cellular Sensitivity to Type I Interferons (2020) (0)
- Faculty Opinions recommendation of A cis-regulatory map of the Drosophila genome. (2011) (0)
- Author response: The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression (2021) (0)
- Faculty Opinions recommendation of Genetic analysis of variation in transcription factor binding in yeast. (2010) (0)
- The NAD+ Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division (2018) (0)
- Venn diagram presenting the results of the GO term-based bioinformatic identification of putative TF (2011) (0)
- marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis (2022) (0)
- Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy (2022) (0)
- Rounding up natural gene expression variation during development. (2013) (0)
- Neuro-toxicogenomic mapping of TMT induced neurotoxicity using human minibrain reveals associated adverse outcome events (2022) (0)
- Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel (2019) (0)
- A YY1 phosphorylation switch in brown adipose tissue orchestrates energy homeostasis. (2021) (0)
- A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion (2023) (0)
- Faculty Opinions recommendation of Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution. (2012) (0)
- Tetracyclines DisturbMito chondrial Function across Eukaryotic Models : A Call for Caution in Biomedical Research Graphical (2015) (0)
- Faculty Opinions recommendation of De novo genesis of enhancers in vertebrates. (2012) (0)
- Table S1 - TF_screen (2014) (0)
- MarrowQuant 2.0: A Digital Pathology Workflow Assisting Bone Marrow Evaluation in Experimental and Clinical Hematology. (2023) (0)
- The Long Noncoding RNA Ctcflos Orchestrates Transcriptional and Post-Transcriptional Alternative Splicing Programs Essential for Thermogenic Gene Expression in Brite Adipocytes (2020) (0)
- Decision letter: Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors (2019) (0)
- Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets (2022) (0)
- Commensal bacteria act as a broad genetic buffer in Drosophila during chronic under-nutrition (2018) (0)
- Cycles of gene expression and genome response during mammalian tissue regeneration (2018) (0)
- Decision letter: Transposase-assisted tagmentation of RNA/DNA hybrid duplexes (2020) (0)
- Supplementary file 1. (2014) (0)
- Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (2022) (0)
- Decision letter: The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila (2018) (0)
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