Bart Vanhaesebroeck

Bart Vanhaesebroeck's AcademicInfluence.com Rankings

Bart Vanhaesebroeck

Biology

#7982

World Rank

#10988

Historical Rank

Cell Biology

#303

World Rank

#311

Historical Rank

Molecular Biology

#969

World Rank

#992

Historical Rank

Neuroscience

#1081

World Rank

#1123

Historical Rank

biology Degrees

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Biology

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Bart Vanhaesebroeck's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Phosphatidylinositol-3-OH kinase direct target of Ras (1994) (2000)
Synthesis and function of 3-phosphorylated inositol lipids. (2001) (1668)
The PI3K-PDK1 connection: more than just a road to PKB. (2000) (1660)
The emerging mechanisms of isoform-specific PI3K signalling (2010) (1518)
Phosphoinositide 3-kinases: a conserved family of signal transducers. (1997) (1004)
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice (2002) (997)
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. (1992) (962)
Signaling by distinct classes of phosphoinositide 3-kinases. (1999) (928)
PI3K signalling: the path to discovery and understanding (2012) (815)
PI3K in lymphocyte development, differentiation and activation (2003) (791)
Signalling through phosphoinositide 3-kinases: the lipids take centre stage. (1999) (721)
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction (1996) (710)
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. (1995) (696)
Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. (1996) (598)
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration (2008) (492)
Signalling by PI3K isoforms: insights from gene-targeted mice. (2005) (479)
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation (2006) (451)
p110δ, a novel phosphoinositide 3-kinase in leukocytes (1997) (374)
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response (2004) (371)
A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system. (1995) (361)
Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer (2014) (360)
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ (2008) (341)
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. (2005) (334)
Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells1 (2006) (322)
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study (2017) (314)
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages (1999) (259)
Kinase-Substrate Enrichment Analysis Provides Insights into the Heterogeneity of Signaling Pathway Activation in Leukemia Cells (2013) (253)
Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase (2006) (241)
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. (2006) (234)
Determinants and clinical implications of chromosomal instability in cancer (2018) (234)
Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia (2005) (234)
PI3K isoforms in cell signalling and vesicle trafficking (2019) (231)
Regulation of phosphoinositide 3-kinase expression in health and disease. (2009) (231)
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers (2007) (219)
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma (2008) (216)
Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing1 (2004) (215)
P110delta, a novel phosphoinositide 3-kinase in leukocytes. (1997) (215)
The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells1 (2006) (203)
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. (2004) (196)
Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. (2006) (185)
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells. (1995) (184)
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy. (2016) (179)
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. (2003) (171)
Activity of any class IA PI3K isoform can sustain cell proliferation and survival (2010) (169)
A Redox-triggered Ras-Effector Interaction (1998) (168)
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (2012) (165)
A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16 (2006) (164)
Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (2005) (158)
Cancer-Associated PIK3CA Mutations in Overgrowth Disorders (2018) (152)
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development (2010) (146)
Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons (2009) (142)
Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans (2016) (139)
PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes (2011) (138)
Generation and Biological Characterization of Membrane-bound, Uncleavable Murine Tumor Necrosis Factor (*) (1995) (138)
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition (2005) (127)
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation. (2007) (125)
Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. (2004) (125)
Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. (2010) (125)
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase (2007) (125)
Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K (2007) (124)
PI3K inhibitors are finally coming of age (2021) (124)
The p110δ isoform of PI 3‐kinase negatively controls RhoA and PTEN (2007) (123)
Role of the phosphoinositide 3‐kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation (2007) (118)
Quantitative Profile of Five Murine Core Proteomes Using Label-free Functional Proteomics*S (2007) (116)
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages (2008) (116)
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. (1993) (113)
Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo1 (2008) (107)
New Responsibilities for the PI3K Regulatory Subunit p85α (2001) (102)
The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1 (2010) (101)
Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: early events in tumour necrosis factor-induced cytotoxicity. (1993) (101)
The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation (2008) (100)
Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α (2014) (99)
Molecules in medicine mini-review: isoforms of PI3K in biology and disease (2015) (99)
Autophosphorylation of p110δ phosphoinositide 3‐kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo (1999) (97)
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism (2013) (94)
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. (2007) (93)
Phosphoinositide 3-Kinase p110δ Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses1 (2009) (93)
The p110δ Isoform of Phosphatidylinositol 3-Kinase Controls Susceptibility to Leishmania major by Regulating Expansion and Tissue Homing of Regulatory T Cells1 (2009) (92)
Structural and functional diversity of phosphoinositide 3-kinases. (1996) (90)
Class I Phosphoinositide 3-Kinase p110β Is Required for Apoptotic Cell and Fcγ Receptor-mediated Phagocytosis by Macrophages* (2003) (87)
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo. (1989) (87)
Two distinct phosphoinositide 3‐kinases mediate polypeptide growth factor‐stimulated PKB activation (2002) (85)
PI3K: from the bench to the clinic and back. (2010) (85)
Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148 (2011) (83)
Dominant Role of the p 110 beta Isoform of PI 3 K over p 110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons (2009) (81)
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se. (1991) (80)
Btk-dependent Rac activation and actin rearrangement following FcεRI aggregation promotes enhanced chemotactic responses of mast cells (2010) (80)
Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ. (2010) (80)
Phosphoinositide 3-kinase in T cell activation and survival. (2004) (79)
The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling. (2000) (77)
PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation. (2011) (77)
PI3K-signalling in B- and T-cells: insights from gene-targeted mice. (2001) (76)
Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases (2005) (75)
Casein Kinase-1 Phosphorylates the p75 Tumor Necrosis Factor Receptor and Negatively Regulates Tumor Necrosis Factor Signaling for Apoptosis (*) (1995) (75)
Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo. (2008) (74)
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. (2011) (74)
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease (2018) (73)
CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway. (2009) (72)
Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate. (2015) (72)
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. (2008) (72)
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor (2011) (71)
Glucose-Potentiated Chemotaxis in Human Vascular Smooth Muscle Is Dependent on Cross-Talk Between the PI3K and MAPK Signaling Pathways (2004) (68)
Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells. (2006) (67)
Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion (2010) (66)
Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits? (2007) (64)
Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity (2015) (64)
Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance* (2012) (61)
Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. (2003) (59)
Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation. (2009) (59)
Quantification of Gel-separated Proteins and Their Phosphorylation Sites by LC-MS Using Unlabeled Internal Standards (2005) (59)
Requirement for Phosphoinositide 3-Kinase p110δ Signaling in B Cell Antigen Receptor-Mediated Antigen Presentation1 (2007) (58)
The study of phosphoinositide 3-kinase function. (1996) (58)
Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer (2016) (57)
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis (2013) (56)
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors (2013) (56)
Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis. (1992) (55)
Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. (2011) (55)
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling (2017) (54)
Distinct Mechanisms of α5β1 Integrin Activation by Ha-Ras and R-Ras* (2000) (54)
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line. (1991) (53)
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism (2017) (52)
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model (2014) (51)
Role of the p110δ PI 3-kinase in integrin and ITAM receptor signalling in platelets (2005) (50)
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo. (1991) (49)
Phosphoinositide 3-Kinase p110 Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses (2009) (49)
The role of PI3Kα isoform in cardioprotection (2017) (48)
Inactivation of PI(3)K p110 delta breaks regulatory T-cell-mediated immune tolerance to cancer (vol 510, pg 407, 2014) (2016) (47)
Essential role of class II PI3K-C2α in platelet membrane morphology. (2015) (47)
Fyn-ADAP signaling via Carma1-Bcl10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells (2013) (47)
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. (2007) (45)
High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation (2012) (45)
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter (2012) (44)
Regulation of p110δ PI 3-Kinase Gene Expression (2009) (44)
A redox-triggered Ras-effector interaction - Recruitment of phosphatidylinositol 5 '-kinase to Ras by redox stress (1998) (43)
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry. (2006) (42)
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner (2018) (41)
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease. (2012) (40)
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells (2015) (40)
Class III Phosphoinositide 3‐Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling (2013) (38)
Phosphoinositide 3-Kinases p110&agr; and p110&bgr; Have Differential Roles in Insulin-Like Growth Factor-1–Mediated Akt Phosphorylation and Platelet Priming (2014) (38)
Gene Targeting Attention to Detail (2004) (38)
Antigen receptor signalling : a distinctive role for the p 110 d isoform of PI 3 K (2007) (38)
PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. (2014) (37)
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth. (2017) (36)
Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients (1992) (34)
Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells* (2014) (32)
Cracking the context-specific PI3K signaling code (2020) (32)
PI3Kδ inhibition hits a sensitive spot in B cell malignancies. (2014) (31)
Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity (2011) (30)
The PI 3 K p 110 alpha isoform regulates endothelial adherens junctions via Pyk 2 and Rac 1 (2010) (30)
Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization (2015) (30)
Corrigendum: Signaling by Fyn-ADAP via the Carma1–Bcl-10–MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells (2014) (29)
mTORC1 activity is supported by spatial association with focal adhesions (2020) (28)
PI3K regulatory subunits lose control in cancer. (2009) (28)
a novel phosphoinositide 3-kinase in leukocytes (1997) (27)
Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse. (2012) (27)
Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif (2007) (27)
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine. (1993) (26)
Killing two kinase families with one stone. (2008) (25)
Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras. (2000) (24)
The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice (2014) (23)
Attenuation of phosphoinositide 3-kinase p110delta signaling restrains autoimmune disease (2012) (23)
Charging the batteries to heal wounds through PI3K (2006) (23)
Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice (2016) (22)
Phosphoinositide 3-kinase in health and disease (2011) (22)
Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth. (2013) (21)
Phosphoinositide lipids in primary cilia biology (2020) (21)
Polar agents with differentiation inducing capacity potentiate tumor necrosis factor‐mediated cytotoxicity in human myeloid cell lines (1995) (20)
Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury (2017) (20)
Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus (2020) (20)
PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart. (2015) (19)
Essential role for the p 110 δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia (2005) (19)
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency (2018) (19)
Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate (2017) (19)
Phosphoinositide 3‐kinase: a new kid on the block in vascular anomalies (2016) (18)
Induction of Unresponsiveness to Tumor Necrosis Factor (TNF) after Autocrine TNF Expression Requires TNF Membrane Retention* (1998) (18)
The PI 3-kinase isoforms p 110 α and p 110 β have differential roles in PDGF-and insulin-mediated signaling (2000) (18)
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent. (1990) (18)
Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway. (2018) (18)
Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration. (2012) (17)
Deletion of the p 110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo (2010) (17)
Human platelets contain p110δ phosphoinositide 3-kinase (2002) (17)
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs (2022) (17)
Impact of PI3K&agr; (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis (2018) (17)
AKT-ing out: SGK kinases come to the fore. (2013) (17)
Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy. (2014) (16)
A new tool to dissect the function of p70 S6 kinase. (2010) (16)
Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3 (2020) (15)
Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury. (2018) (15)
Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity. (1994) (14)
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis (2020) (14)
Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation (2016) (14)
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride. (1991) (14)
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy (2021) (14)
Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts. (2019) (13)
Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection. (2014) (13)
Human platelets contain p110delta phosphoinositide 3-kinase. (2002) (13)
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter (1990) (12)
p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model (2019) (12)
Functional CSF‐1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3‐kinase (2012) (12)
Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation (2020) (12)
Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome (2018) (11)
A new TIPE of phosphoinositide regulator in cancer. (2014) (11)
Gene cloning and structure--function relationship of cytokines such as TNF and interleukins. (1987) (11)
Autocrine Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) α Differentially Modulate Cellular Sensitivity to TNF/LT-α Cytotoxicity in L929 Cells (1998) (11)
Structure-function relationship of tumour necrosis factor and its mechanism of action. (1987) (10)
PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction (2019) (10)
Inactivation of endothelial cell phosphoinositide 3-kinase β inhibits tumor angiogenesis and tumor growth (2020) (10)
The class I phosphoinositide 3-kinases α and β control antiphospholipid antibodies-induced platelet activation (2016) (10)
An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity. (1989) (9)
The p110 delta isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (vol 13, pg 1045, 2012) (2013) (9)
PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias (2019) (9)
Structure-function relationship of tumor necrosis factor and its mechanism of action (1987) (9)
Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma. (2021) (8)
PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity (2021) (8)
Targeting PI3Kδ function for amelioration of murine chronic graft‐versus‐host disease (2019) (8)
Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability (2019) (8)
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype (2021) (7)
Inactivation of PI3K (cid:1) and PI3K (cid:2) distorts T-cell development and causes multiple organ inﬂammation (2007) (7)
TNF: its potential as an antitumour agent. (1988) (6)
Brief report Deletion of the p110 (cid:1) isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo (2010) (6)
PI3K isoforms in cell signalling and vesicle trafficking (2019) (6)
Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation. (2022) (6)
Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover (2022) (6)
Blockade of p110delta isoform activity of phosphoinositide 3-kinase inhibits blast cell proliferation in acute myeloblastic leukemia. (2004) (5)
Genetic or pharmaceutical blockade of p 110 d phosphoinositide 3-kinase enhances IgE production (5)
In vitro and in vivo Action of Tumor Necrosis Factor1 (1990) (5)
Tissue Homing of Regulatory T Cells by Regulating Expansion Leishmania major 3-Kinase Controls Susceptibility to Isoform of Phosphatidylinositol δ The p 110 (2009) (5)
NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells (2019) (5)
Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach (2021) (4)
Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (2013) (4)
Pharmacological and cell-specific genetic PI3Kα inhibition worsens cardiac remodeling after myocardial infarction. (2021) (4)
Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm (2021) (4)
SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target (2021) (3)
The Phosphoinositide 3-Kinase Isoform PI 3 K Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice (2014) (3)
Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus (2021) (3)
Immunomodulatory effects of PI3Kδ inhibition in solid tumors – evaluation in a randomized phase II trial (2021) (3)
Relationship between stemness and transcriptionally-inferred PI3K activity in human breast cancer (2020) (3)
Abstract 15697: Acute Pharmacological Inhibition of PI3Kα by the Novel Cancer Drug, BYL-719, Has a Pro-arrhythmic Effect (2016) (3)
High-dose oncogenic PIK3CA drives constitutive cellular stemness through self-sustained TGFβ pathway activation (2019) (3)
A randomised, double-blind, placebo-controlled phase IIa trial of AMG319 given orally as neoadjuvant therapy in patients with human papillomavirus (HPV) positive and negative head and neck squamous cell carcinoma (HNSCC). (2018) (3)
The PI 3 K p 110 isoform regulates endothelial adherens junctions via Pyk 2 and Rac 1 (2010) (2)
Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis. (2020) (2)
Autocrine Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) (cid:97) Differentially Modulate Cellular Sensitivity to TNF/LT- (cid:97) Cytotoxicity in L929 Cells (1998) (2)
Tumour Necrosis Factor and Interleukin-6: Structure and Mechanism of Action of the Molecular, Cellular and in Vivo Level (1989) (2)
Long-term treatment with low dose rapamycin extends lifespan and delays tumours in cancer-prone germline PTEN mutant mice. (2022) (2)
HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models (2022) (2)
Author Correction: PI3K inhibitors are finally coming of age (2021) (2)
The Pten/PI3K pathway governs the homeostasis of V (cid:1) 14 i NKT cells (2006) (2)
The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in (2000) (2)
Synergy between interferon and tumor-necrosis-factor - mechanism of action (1987) (2)
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling (2017) (1)
Mouse Phenotypes - A Handbook of Mutation Analysis By Virginia E. Papaioannou & Richard R. Behringer (2005) (1)
Vps 34 / PI 3 KC 3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux , causing a Fanconi-like syndrome and renal insufficiency (2018) (1)
Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion (2022) (1)
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors (2013) (1)
PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis (2017) (1)
Deal watch: Infinity and Intellikine to develop oral PI3K inhibitors for inflammatory diseases (2010) (1)
Comprar Phosphoinositide 3-kinase in Health and Disease | Rommel, Christian | 9783642148156 | Springer (2011) (1)
Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with PIK3CA genotype in breast cancer (2020) (1)
Cancer drug tackles overgrowth syndrome (2018) (1)
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development (2022) (1)
PIK3CD (phosphoinositide -3-kinase, catalytic, delta polypeptide) (2012) (1)
Comprar Phosphoinositide 3-Kinase In Health And Disease (Current Topics In Microbiology And Immunology, Vol. 346) | Vogt, Peter K. | 9783642136627 | Springer (2010) (1)
Document S1. Supplemental Experimental Procedures, 12 Figures, 3 Tables, and Supplemental References (2009) (0)
The role of the p110 delta PI3-kinase isoform in inflammatory bowel disease (2007) (0)
104 Plasma metabolomic analysis of genetic and pharmacological manipulation of PI 3-kinase pathway activation in mice using liquid chromatography coupled to mass spectrometry (LC-MS) (2010) (0)
Edinburgh Research Explorer Dominant Role of the p110 beta Isoform of PI3K over p110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons (2018) (0)
Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome (2018) (0)
Inactivating the lipid kinase activity of PI3KC2β is sufficient to rescue myotubular myopathy in mice. (2023) (0)
PI 3-kinases and lipid messengers (2020) (0)
Two Pathways of Tumor Necrosis Factor Signal Transduction: In vitro and in vivo Implications (1993) (0)
PI3K alpha Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury (2016) (0)
PI 3 K a Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction (2019) (0)
NODAL/TGFβ signalling mediates the self-sustained stemness induced by <italic>PIK3CA<sup>H1047R</sup></italic> homozygosity in pluripotent stem cells (2021) (0)
The p110 delta isoform of phosphatidylinositol 3-kinase associates with the T lymphocyte costimulatory molecule CD28. (1998) (0)
Glucose-potentiated vascular smooth muscle cell chemotaxis is mediated by phospholnositide-3-kinase-p110 beta (2001) (0)
Uninephrectomy and class II PI3K‐C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice (2020) (0)
107 INVITED Biological roles of PI 3-kinase isoforms (2007) (0)
Session 6: Mechanisms of allergic disease (2004) (0)
Abstract A86: Inactivation of p110delta PI3K releases potent antitumor immunity. (2013) (0)
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs (2022) (0)
Elevated glucose concentration potentiates vascular smooth muscle cell chemotaxis via both phosphoinositide 3-kinase-p110 beta and protein kinase C beta (2002) (0)
activity is supported by spatial association with focal adhesions. Biology, (2021) (0)
The generation of mitochondrial oxygen radicals as a crucial step in the cytotoxic action of TNF (1991) (0)
Abstract IA12: New roles for PI3K isoforms in cancer (2015) (0)
A critical role for c-kit on dendritic cells in regulating in T helper cell differentiation and allergic asthma (79.3) (2009) (0)
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease (2018) (0)
PI 3-kinase signalling enzymes & lipid messengers (2007) (0)
The β-isoform of the p110 catalytic subunit of PI3-kinase mediates chemotaxis of vascular smooth muscle cells exposed to high glucose concentration (2002) (0)
Vps34/PIK3C3 deletion in thyroid impairs thyroid hormonogenesis and autophagic flux (2019) (0)
566: Investigating PI3Kinase and K-ras pathway interactions in mouse model of colorectal cancer (2014) (0)
Regulation of PI 3 K expression (2018) (0)
Signaling by ADAP via the Carma1-TAK1 axis is critical for pro-inflammatory cytokine production but not for cytotoxicity in NK cells. (IRM7P.477) (2014) (0)
Session 3: Signalling in inflammatory and immune cells: cell surface to nucleus (2004) (0)
Phosphoinositide 3-kinase p110delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses (93.23) (2009) (0)
THU0045 Epratuzumab, an Antibody Targeting CD22 on B Cells, Induces Phosphoprotein Changes Following B-Cell Receptor Activation in Vitro (2013) (0)
649. Targeting Innate Host Immunity Through PI3K Delta for Enhancement of Systemic Delivery of Oncolytic Vaccinia Virus (2015) (0)
TNF-gene expression confers TNF-resistance (1990) (0)
Molecules in medicine mini-review: isoforms of PI3K in biology and disease (2015) (0)
Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis (2020) (0)
The non-mutated PI3Kalpha is a master signaling enzyme for pancreatic cancerogenesis (2014) (0)
Abstract 4489: The activity of novel, potent, selective PI3K/mTOR pathway inhibitors in B-cell malignancies (2010) (0)
PI3K Regulatory Subunits Lose Control in Cancer (DOI:10.1016/j.ccr.2009.11.017) (2010) (0)
CLASS I PI3K ISOFORMS δ AND γ REGULATE KEY RESPONSES OF CERULEIN-INDUCED PANCREATITIS. PI3Kδ IS NECESSARY FOR TRYPSIN ACTIVATION (2005) (0)
New roles for PI3K isoforms in cancer (2015) (0)
Idelalisib inhibits experimental proliferative vitroretinopathy. (2022) (0)
Targeting PI3K signaling to ameliorate chronic graft versus host disease. (2016) (0)
0448 : Essential role of platelet PI3Kβ and GSK3 in thrombus stability at high shear rate (2015) (0)
Abstract 14440: PI3Kα Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury (2016) (0)
PI 3-kinase : a new kid on the block in vascular anomalies (2016) (0)
High levels of p110 (cid:1) PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110 (cid:1) inhibitors through PTEN activation (2020) (0)
Reduced Akt and increased RhoA/PTEN signaling in DRG neurons with inactive p110δ. (2007) (0)
Abstract 16253: Distinctive Functions of PI3Kβ in Endothelial Cells and Cardiomyocytes in Response to Myocardial Infarction: Complications for Targeting PI3Kβ in Myocardial Infarction Treatment (2016) (0)
Abstract 13474: PI3K{alpha} is Required for Recovery from Transient Cre/tamoxifen Induced Cardiotoxicity (2012) (0)
PI 108, A novel human phosphoinositide 3-kinase (1996) (0)
The PI 3 kinase family - Diversity in substrate specificity and activation mechanisms. (1996) (0)
CD4+CD25+Foxp3+ Regulatory T Cells Is Critical for the Function of δ p110Edge: The Phosphoinositide 3-Kinase (2013) (0)
Tumor necrosis factor: Mechanisms of action and potential role in cancer treatment (1993) (0)
Author Correction: PI3K inhibitors are finally coming of age (2021) (0)
Tumor Necrosis Factor: Mechanism of Action and its Potential for Anticancer Therapy (1992) (0)
Low dose of cancer drug improves overgrowth syndrome : lessons for cancer therapy ? (2018) (0)
NFκB-Mediated Expression of Phosphoinositide 3-Kinase δ Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells (2023) (0)
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism (2017) (0)
Cancer Cell Previews PI 3 K Regulatory Subunits Lose Control in Cancer (2009) (0)
Vivo Invasiveness Correlates with Reduced Tumorigenicity and Reduced Expression of the Tumor Necrosis Factor Gene in Tumor Cells (2006) (0)
Phosphoinositide 3-Kinases : p 110 Isoform-Specific Functions of Vanhaesebroeck (2008) (0)
Idelalisib inhibits experimental proliferative vitroretinopathy (2022) (0)
Insights into the biology of class I PI3K isoforms and translation to the clinic (2018) (0)
B-1 B Cell Function , and Autoantibody ZoneNatural Antibody Production , Marginal Regulates δ Phosphoinositide 3-Kinase p 110 Witztum (2009) (0)
Complexes PI 3 K { beta } Plays a Critical Role in Neutrophil Activation by Immune ` (2011) (0)
PI 3K in the Immune System PI 3-Kinase in the Immune System (2003) (0)
Title : Somatic Activating Mutations in Pik 3 ca Cause Sporadic Venous Malformations in Mice and Humans (2016) (0)
Endothelial phosphoinositide 3-kinase-β inactivation confers protection from immune-mediated vascular injury. (2023) (0)
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency (2018) (0)
Activated PI3-Kinase Delta Syndrome: Clinical, Radiological And Laboratory Features Of A Large Cohort. (2015) (0)
Sensitization of T \ imor Cells to l \ imor Necrosis Factor Action by the Protein Kinase Inhibitor Staurosporine 1 (2006) (0)
Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis (2019) (0)
Genome Editing of Pik3cd Impedes Abnormal Retinal Angiogenesis. (2022) (0)
3rd Focused Meeting on PI3K Signalling and Disease (2007) (0)
Abstract 16333: PI3Kα Has a Role in Myocardial Insulin Signaling and Recovery From Cre/Tamoxifen Cardiotoxicity, but is not Required for Normal Function in the Adult Mouse Heart (2014) (0)
The mouse made easy (2005) (0)
Regulation of Macrophage signal transduction by p110δ PI3K (2018) (0)
Role of P110alpha isoform of class I PI3-kinases in platelet activation and functions (2015) (0)
p110beta PI3K isoform regulates microcrystals phagocytosis and crystal- mediated inflammasome activation in autoinflammatory disease (2014) (0)
Distinctive Functions of PI3K beta in Endothelial Cells and Cardiomyocytes in Response to Myocardial Infarction: Complications for Targeting PI3K beta in Myocardial Infarction Treatment (2016) (0)
Abstract 80: PI3Kα Regulates Biomechanical Stress-induced Cytoskeletal Remodeling: A Critical Role of Gelsolin (2016) (0)
ErratumPI3K Regulatory Subunits Lose Control in Cancer (2010) (0)
Search for genetic variability of the phosphoinositide 3-kinase (P13-K) in late onset Alzheimer's disease (2000) (0)
Abstract B22: Investigation of PTEN genotype-phenotype correlations in the PTEN hamartoma tumor syndrome (PHTS) using in vitro and in vivo approaches (2020) (0)

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