Bart Vanhaesebroeck
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(Suggest an Edit or Addition)Bart Vanhaesebroeck's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Phosphatidylinositol-3-OH kinase direct target of Ras (1994) (2000)
- Synthesis and function of 3-phosphorylated inositol lipids. (2001) (1668)
- The PI3K-PDK1 connection: more than just a road to PKB. (2000) (1660)
- The emerging mechanisms of isoform-specific PI3K signalling (2010) (1518)
- Phosphoinositide 3-kinases: a conserved family of signal transducers. (1997) (1004)
- Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice (2002) (997)
- Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. (1992) (962)
- Signaling by distinct classes of phosphoinositide 3-kinases. (1999) (928)
- PI3K signalling: the path to discovery and understanding (2012) (815)
- PI3K in lymphocyte development, differentiation and activation (2003) (791)
- Signalling through phosphoinositide 3-kinases: the lipids take centre stage. (1999) (721)
- Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction (1996) (710)
- Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. (1995) (696)
- Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. (1996) (598)
- Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration (2008) (492)
- Signalling by PI3K isoforms: insights from gene-targeted mice. (2005) (479)
- Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation (2006) (451)
- p110δ, a novel phosphoinositide 3-kinase in leukocytes (1997) (374)
- Essential role for the p110δ phosphoinositide 3-kinase in the allergic response (2004) (371)
- A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system. (1995) (361)
- Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer (2014) (360)
- The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ (2008) (341)
- Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. (2005) (334)
- Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells1 (2006) (322)
- Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study (2017) (314)
- Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages (1999) (259)
- Kinase-Substrate Enrichment Analysis Provides Insights into the Heterogeneity of Signaling Pathway Activation in Leukemia Cells (2013) (253)
- Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase (2006) (241)
- Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. (2006) (234)
- Determinants and clinical implications of chromosomal instability in cancer (2018) (234)
- Essential role for the p110δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia (2005) (234)
- PI3K isoforms in cell signalling and vesicle trafficking (2019) (231)
- Regulation of phosphoinositide 3-kinase expression in health and disease. (2009) (231)
- Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers (2007) (219)
- Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma (2008) (216)
- Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and Homing1 (2004) (215)
- P110delta, a novel phosphoinositide 3-kinase in leukocytes. (1997) (215)
- The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells1 (2006) (203)
- Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. (2004) (196)
- Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase. (2006) (185)
- Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells. (1995) (184)
- Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy. (2016) (179)
- Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. (2003) (171)
- Activity of any class IA PI3K isoform can sustain cell proliferation and survival (2010) (169)
- A Redox-triggered Ras-Effector Interaction (1998) (168)
- The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (2012) (165)
- A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16 (2006) (164)
- Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (2005) (158)
- Cancer-Associated PIK3CA Mutations in Overgrowth Disorders (2018) (152)
- The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development (2010) (146)
- Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons (2009) (142)
- Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans (2016) (139)
- PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes (2011) (138)
- Generation and Biological Characterization of Membrane-bound, Uncleavable Murine Tumor Necrosis Factor (*) (1995) (138)
- Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition (2005) (127)
- Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation. (2007) (125)
- Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. (2004) (125)
- Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. (2010) (125)
- Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase (2007) (125)
- Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K (2007) (124)
- PI3K inhibitors are finally coming of age (2021) (124)
- The p110δ isoform of PI 3‐kinase negatively controls RhoA and PTEN (2007) (123)
- Role of the phosphoinositide 3‐kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation (2007) (118)
- Quantitative Profile of Five Murine Core Proteomes Using Label-free Functional Proteomics*S (2007) (116)
- Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages (2008) (116)
- Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. (1993) (113)
- Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo1 (2008) (107)
- New Responsibilities for the PI3K Regulatory Subunit p85α (2001) (102)
- The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1 (2010) (101)
- Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: early events in tumour necrosis factor-induced cytotoxicity. (1993) (101)
- The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation (2008) (100)
- Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α (2014) (99)
- Molecules in medicine mini-review: isoforms of PI3K in biology and disease (2015) (99)
- Autophosphorylation of p110δ phosphoinositide 3‐kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo (1999) (97)
- Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism (2013) (94)
- The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. (2007) (93)
- Phosphoinositide 3-Kinase p110δ Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses1 (2009) (93)
- The p110δ Isoform of Phosphatidylinositol 3-Kinase Controls Susceptibility to Leishmania major by Regulating Expansion and Tissue Homing of Regulatory T Cells1 (2009) (92)
- Structural and functional diversity of phosphoinositide 3-kinases. (1996) (90)
- Class I Phosphoinositide 3-Kinase p110β Is Required for Apoptotic Cell and Fcγ Receptor-mediated Phagocytosis by Macrophages* (2003) (87)
- Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo. (1989) (87)
- Two distinct phosphoinositide 3‐kinases mediate polypeptide growth factor‐stimulated PKB activation (2002) (85)
- PI3K: from the bench to the clinic and back. (2010) (85)
- Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148 (2011) (83)
- Dominant Role of the p 110 beta Isoform of PI 3 K over p 110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons (2009) (81)
- Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se. (1991) (80)
- Btk-dependent Rac activation and actin rearrangement following FcεRI aggregation promotes enhanced chemotactic responses of mast cells (2010) (80)
- Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ. (2010) (80)
- Phosphoinositide 3-kinase in T cell activation and survival. (2004) (79)
- The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling. (2000) (77)
- PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation. (2011) (77)
- PI3K-signalling in B- and T-cells: insights from gene-targeted mice. (2001) (76)
- Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases (2005) (75)
- Casein Kinase-1 Phosphorylates the p75 Tumor Necrosis Factor Receptor and Negatively Regulates Tumor Necrosis Factor Signaling for Apoptosis (*) (1995) (75)
- Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo. (2008) (74)
- Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. (2011) (74)
- PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease (2018) (73)
- CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway. (2009) (72)
- Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate. (2015) (72)
- Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. (2008) (72)
- Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor (2011) (71)
- Glucose-Potentiated Chemotaxis in Human Vascular Smooth Muscle Is Dependent on Cross-Talk Between the PI3K and MAPK Signaling Pathways (2004) (68)
- Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells. (2006) (67)
- Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion (2010) (66)
- Regulation of class IA PI3Ks: is there a role for monomeric PI3K subunits? (2007) (64)
- Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity (2015) (64)
- Phosphoproteomic Analysis of Leukemia Cells under Basal and Drug-treated Conditions Identifies Markers of Kinase Pathway Activation and Mechanisms of Resistance* (2012) (61)
- Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages. (2003) (59)
- Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation. (2009) (59)
- Quantification of Gel-separated Proteins and Their Phosphorylation Sites by LC-MS Using Unlabeled Internal Standards (2005) (59)
- Requirement for Phosphoinositide 3-Kinase p110δ Signaling in B Cell Antigen Receptor-Mediated Antigen Presentation1 (2007) (58)
- The study of phosphoinositide 3-kinase function. (1996) (58)
- Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer (2016) (57)
- Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis (2013) (56)
- Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors (2013) (56)
- Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis. (1992) (55)
- Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. (2011) (55)
- Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling (2017) (54)
- Distinct Mechanisms of α5β1 Integrin Activation by Ha-Ras and R-Ras* (2000) (54)
- Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line. (1991) (53)
- Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism (2017) (52)
- PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model (2014) (51)
- Role of the p110δ PI 3-kinase in integrin and ITAM receptor signalling in platelets (2005) (50)
- Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo. (1991) (49)
- Phosphoinositide 3-Kinase p110 Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses (2009) (49)
- The role of PI3Kα isoform in cardioprotection (2017) (48)
- Inactivation of PI(3)K p110 delta breaks regulatory T-cell-mediated immune tolerance to cancer (vol 510, pg 407, 2014) (2016) (47)
- Essential role of class II PI3K-C2α in platelet membrane morphology. (2015) (47)
- Fyn-ADAP signaling via Carma1-Bcl10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells (2013) (47)
- The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. (2007) (45)
- High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation (2012) (45)
- Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter (2012) (44)
- Regulation of p110δ PI 3-Kinase Gene Expression (2009) (44)
- A redox-triggered Ras-effector interaction - Recruitment of phosphatidylinositol 5 '-kinase to Ras by redox stress (1998) (43)
- Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry. (2006) (42)
- Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner (2018) (41)
- Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease. (2012) (40)
- Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells (2015) (40)
- Class III Phosphoinositide 3‐Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling (2013) (38)
- Phosphoinositide 3-Kinases p110&agr; and p110&bgr; Have Differential Roles in Insulin-Like Growth Factor-1–Mediated Akt Phosphorylation and Platelet Priming (2014) (38)
- Gene Targeting Attention to Detail (2004) (38)
- Antigen receptor signalling : a distinctive role for the p 110 d isoform of PI 3 K (2007) (38)
- PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. (2014) (37)
- A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth. (2017) (36)
- Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients (1992) (34)
- Environmental Stress Affects the Activity of Metabolic and Growth Factor Signaling Networks and Induces Autophagy Markers in MCF7 Breast Cancer Cells* (2014) (32)
- Cracking the context-specific PI3K signaling code (2020) (32)
- PI3Kδ inhibition hits a sensitive spot in B cell malignancies. (2014) (31)
- Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity (2011) (30)
- The PI 3 K p 110 alpha isoform regulates endothelial adherens junctions via Pyk 2 and Rac 1 (2010) (30)
- Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization (2015) (30)
- Corrigendum: Signaling by Fyn-ADAP via the Carma1–Bcl-10–MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells (2014) (29)
- mTORC1 activity is supported by spatial association with focal adhesions (2020) (28)
- PI3K regulatory subunits lose control in cancer. (2009) (28)
- a novel phosphoinositide 3-kinase in leukocytes (1997) (27)
- Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse. (2012) (27)
- Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif (2007) (27)
- Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine. (1993) (26)
- Killing two kinase families with one stone. (2008) (25)
- Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras. (2000) (24)
- The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice (2014) (23)
- Attenuation of phosphoinositide 3-kinase p110delta signaling restrains autoimmune disease (2012) (23)
- Charging the batteries to heal wounds through PI3K (2006) (23)
- Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice (2016) (22)
- Phosphoinositide 3-kinase in health and disease (2011) (22)
- Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth. (2013) (21)
- Phosphoinositide lipids in primary cilia biology (2020) (21)
- Polar agents with differentiation inducing capacity potentiate tumor necrosis factor‐mediated cytotoxicity in human myeloid cell lines (1995) (20)
- Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury (2017) (20)
- Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus (2020) (20)
- PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart. (2015) (19)
- Essential role for the p 110 δ isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia (2005) (19)
- Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency (2018) (19)
- Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate (2017) (19)
- Phosphoinositide 3‐kinase: a new kid on the block in vascular anomalies (2016) (18)
- Induction of Unresponsiveness to Tumor Necrosis Factor (TNF) after Autocrine TNF Expression Requires TNF Membrane Retention* (1998) (18)
- The PI 3-kinase isoforms p 110 α and p 110 β have differential roles in PDGF-and insulin-mediated signaling (2000) (18)
- Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent. (1990) (18)
- Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway. (2018) (18)
- Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration. (2012) (17)
- Deletion of the p 110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo (2010) (17)
- Human platelets contain p110δ phosphoinositide 3-kinase (2002) (17)
- Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs (2022) (17)
- Impact of PI3K&agr; (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis (2018) (17)
- AKT-ing out: SGK kinases come to the fore. (2013) (17)
- Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy. (2014) (16)
- A new tool to dissect the function of p70 S6 kinase. (2010) (16)
- Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3 (2020) (15)
- Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury. (2018) (15)
- Functional requirement of the two TNF receptors for induction of apoptosis in PC60 cells and the role of mitochondria in TNF-induced cytotoxicity. (1994) (14)
- PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis (2020) (14)
- Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation (2016) (14)
- Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride. (1991) (14)
- Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy (2021) (14)
- Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts. (2019) (13)
- Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection. (2014) (13)
- Human platelets contain p110delta phosphoinositide 3-kinase. (2002) (13)
- Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter (1990) (12)
- p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model (2019) (12)
- Functional CSF‐1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3‐kinase (2012) (12)
- Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation (2020) (12)
- Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome (2018) (11)
- A new TIPE of phosphoinositide regulator in cancer. (2014) (11)
- Gene cloning and structure--function relationship of cytokines such as TNF and interleukins. (1987) (11)
- Autocrine Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) α Differentially Modulate Cellular Sensitivity to TNF/LT-α Cytotoxicity in L929 Cells (1998) (11)
- Structure-function relationship of tumour necrosis factor and its mechanism of action. (1987) (10)
- PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction (2019) (10)
- Inactivation of endothelial cell phosphoinositide 3-kinase β inhibits tumor angiogenesis and tumor growth (2020) (10)
- The class I phosphoinositide 3-kinases α and β control antiphospholipid antibodies-induced platelet activation (2016) (10)
- An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity. (1989) (9)
- The p110 delta isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (vol 13, pg 1045, 2012) (2013) (9)
- PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias (2019) (9)
- Structure-function relationship of tumor necrosis factor and its mechanism of action (1987) (9)
- Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma. (2021) (8)
- PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity (2021) (8)
- Targeting PI3Kδ function for amelioration of murine chronic graft‐versus‐host disease (2019) (8)
- Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability (2019) (8)
- Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype (2021) (7)
- Inactivation of PI3K (cid:1) and PI3K (cid:2) distorts T-cell development and causes multiple organ inflammation (2007) (7)
- TNF: its potential as an antitumour agent. (1988) (6)
- Brief report Deletion of the p110 (cid:1) isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo (2010) (6)
- PI3K isoforms in cell signalling and vesicle trafficking (2019) (6)
- Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation. (2022) (6)
- Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover (2022) (6)
- Blockade of p110delta isoform activity of phosphoinositide 3-kinase inhibits blast cell proliferation in acute myeloblastic leukemia. (2004) (5)
- Genetic or pharmaceutical blockade of p 110 d phosphoinositide 3-kinase enhances IgE production (5)
- In vitro and in vivo Action of Tumor Necrosis Factor1 (1990) (5)
- Tissue Homing of Regulatory T Cells by Regulating Expansion Leishmania major 3-Kinase Controls Susceptibility to Isoform of Phosphatidylinositol δ The p 110 (2009) (5)
- NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells (2019) (5)
- Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach (2021) (4)
- Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (2013) (4)
- Pharmacological and cell-specific genetic PI3Kα inhibition worsens cardiac remodeling after myocardial infarction. (2021) (4)
- Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm (2021) (4)
- SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target (2021) (3)
- The Phosphoinositide 3-Kinase Isoform PI 3 K Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice (2014) (3)
- Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus (2021) (3)
- Immunomodulatory effects of PI3Kδ inhibition in solid tumors – evaluation in a randomized phase II trial (2021) (3)
- Relationship between stemness and transcriptionally-inferred PI3K activity in human breast cancer (2020) (3)
- Abstract 15697: Acute Pharmacological Inhibition of PI3Kα by the Novel Cancer Drug, BYL-719, Has a Pro-arrhythmic Effect (2016) (3)
- High-dose oncogenic PIK3CA drives constitutive cellular stemness through self-sustained TGFβ pathway activation (2019) (3)
- A randomised, double-blind, placebo-controlled phase IIa trial of AMG319 given orally as neoadjuvant therapy in patients with human papillomavirus (HPV) positive and negative head and neck squamous cell carcinoma (HNSCC). (2018) (3)
- The PI 3 K p 110 isoform regulates endothelial adherens junctions via Pyk 2 and Rac 1 (2010) (2)
- Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis. (2020) (2)
- Autocrine Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) (cid:97) Differentially Modulate Cellular Sensitivity to TNF/LT- (cid:97) Cytotoxicity in L929 Cells (1998) (2)
- Tumour Necrosis Factor and Interleukin-6: Structure and Mechanism of Action of the Molecular, Cellular and in Vivo Level (1989) (2)
- Long-term treatment with low dose rapamycin extends lifespan and delays tumours in cancer-prone germline PTEN mutant mice. (2022) (2)
- HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models (2022) (2)
- Author Correction: PI3K inhibitors are finally coming of age (2021) (2)
- The Pten/PI3K pathway governs the homeostasis of V (cid:1) 14 i NKT cells (2006) (2)
- The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in (2000) (2)
- Synergy between interferon and tumor-necrosis-factor - mechanism of action (1987) (2)
- Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling (2017) (1)
- Mouse Phenotypes - A Handbook of Mutation Analysis By Virginia E. Papaioannou & Richard R. Behringer (2005) (1)
- Vps 34 / PI 3 KC 3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux , causing a Fanconi-like syndrome and renal insufficiency (2018) (1)
- Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion (2022) (1)
- Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors (2013) (1)
- PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis (2017) (1)
- Deal watch: Infinity and Intellikine to develop oral PI3K inhibitors for inflammatory diseases (2010) (1)
- Comprar Phosphoinositide 3-kinase in Health and Disease | Rommel, Christian | 9783642148156 | Springer (2011) (1)
- Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with PIK3CA genotype in breast cancer (2020) (1)
- Cancer drug tackles overgrowth syndrome (2018) (1)
- Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development (2022) (1)
- PIK3CD (phosphoinositide -3-kinase, catalytic, delta polypeptide) (2012) (1)
- Comprar Phosphoinositide 3-Kinase In Health And Disease (Current Topics In Microbiology And Immunology, Vol. 346) | Vogt, Peter K. | 9783642136627 | Springer (2010) (1)
- Document S1. Supplemental Experimental Procedures, 12 Figures, 3 Tables, and Supplemental References (2009) (0)
- The role of the p110 delta PI3-kinase isoform in inflammatory bowel disease (2007) (0)
- 104 Plasma metabolomic analysis of genetic and pharmacological manipulation of PI 3-kinase pathway activation in mice using liquid chromatography coupled to mass spectrometry (LC-MS) (2010) (0)
- Edinburgh Research Explorer Dominant Role of the p110 beta Isoform of PI3K over p110 alpha in Energy Homeostasis Regulation by POMC and AgRP Neurons (2018) (0)
- Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome (2018) (0)
- Inactivating the lipid kinase activity of PI3KC2β is sufficient to rescue myotubular myopathy in mice. (2023) (0)
- PI 3-kinases and lipid messengers (2020) (0)
- Two Pathways of Tumor Necrosis Factor Signal Transduction: In vitro and in vivo Implications (1993) (0)
- PI3K alpha Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury (2016) (0)
- PI 3 K a Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction (2019) (0)
- NODAL/TGFβ signalling mediates the self-sustained stemness induced by <italic>PIK3CA<sup>H1047R</sup></italic> homozygosity in pluripotent stem cells (2021) (0)
- The p110 delta isoform of phosphatidylinositol 3-kinase associates with the T lymphocyte costimulatory molecule CD28. (1998) (0)
- Glucose-potentiated vascular smooth muscle cell chemotaxis is mediated by phospholnositide-3-kinase-p110 beta (2001) (0)
- Uninephrectomy and class II PI3K‐C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice (2020) (0)
- 107 INVITED Biological roles of PI 3-kinase isoforms (2007) (0)
- Session 6: Mechanisms of allergic disease (2004) (0)
- Abstract A86: Inactivation of p110delta PI3K releases potent antitumor immunity. (2013) (0)
- Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs (2022) (0)
- Elevated glucose concentration potentiates vascular smooth muscle cell chemotaxis via both phosphoinositide 3-kinase-p110 beta and protein kinase C beta (2002) (0)
- activity is supported by spatial association with focal adhesions. Biology, (2021) (0)
- The generation of mitochondrial oxygen radicals as a crucial step in the cytotoxic action of TNF (1991) (0)
- Abstract IA12: New roles for PI3K isoforms in cancer (2015) (0)
- A critical role for c-kit on dendritic cells in regulating in T helper cell differentiation and allergic asthma (79.3) (2009) (0)
- PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease (2018) (0)
- PI 3-kinase signalling enzymes & lipid messengers (2007) (0)
- The β-isoform of the p110 catalytic subunit of PI3-kinase mediates chemotaxis of vascular smooth muscle cells exposed to high glucose concentration (2002) (0)
- Vps34/PIK3C3 deletion in thyroid impairs thyroid hormonogenesis and autophagic flux (2019) (0)
- 566: Investigating PI3Kinase and K-ras pathway interactions in mouse model of colorectal cancer (2014) (0)
- Regulation of PI 3 K expression (2018) (0)
- Signaling by ADAP via the Carma1-TAK1 axis is critical for pro-inflammatory cytokine production but not for cytotoxicity in NK cells. (IRM7P.477) (2014) (0)
- Session 3: Signalling in inflammatory and immune cells: cell surface to nucleus (2004) (0)
- Phosphoinositide 3-kinase p110delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses (93.23) (2009) (0)
- THU0045 Epratuzumab, an Antibody Targeting CD22 on B Cells, Induces Phosphoprotein Changes Following B-Cell Receptor Activation in Vitro (2013) (0)
- 649. Targeting Innate Host Immunity Through PI3K Delta for Enhancement of Systemic Delivery of Oncolytic Vaccinia Virus (2015) (0)
- TNF-gene expression confers TNF-resistance (1990) (0)
- Molecules in medicine mini-review: isoforms of PI3K in biology and disease (2015) (0)
- Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis (2020) (0)
- The non-mutated PI3Kalpha is a master signaling enzyme for pancreatic cancerogenesis (2014) (0)
- Abstract 4489: The activity of novel, potent, selective PI3K/mTOR pathway inhibitors in B-cell malignancies (2010) (0)
- PI3K Regulatory Subunits Lose Control in Cancer (DOI:10.1016/j.ccr.2009.11.017) (2010) (0)
- CLASS I PI3K ISOFORMS δ AND γ REGULATE KEY RESPONSES OF CERULEIN-INDUCED PANCREATITIS. PI3Kδ IS NECESSARY FOR TRYPSIN ACTIVATION (2005) (0)
- New roles for PI3K isoforms in cancer (2015) (0)
- Idelalisib inhibits experimental proliferative vitroretinopathy. (2022) (0)
- Targeting PI3K signaling to ameliorate chronic graft versus host disease. (2016) (0)
- 0448 : Essential role of platelet PI3Kβ and GSK3 in thrombus stability at high shear rate (2015) (0)
- Abstract 14440: PI3Kα Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury (2016) (0)
- PI 3-kinase : a new kid on the block in vascular anomalies (2016) (0)
- High levels of p110 (cid:1) PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110 (cid:1) inhibitors through PTEN activation (2020) (0)
- Reduced Akt and increased RhoA/PTEN signaling in DRG neurons with inactive p110δ. (2007) (0)
- Abstract 16253: Distinctive Functions of PI3Kβ in Endothelial Cells and Cardiomyocytes in Response to Myocardial Infarction: Complications for Targeting PI3Kβ in Myocardial Infarction Treatment (2016) (0)
- Abstract 13474: PI3K{alpha} is Required for Recovery from Transient Cre/tamoxifen Induced Cardiotoxicity (2012) (0)
- PI 108, A novel human phosphoinositide 3-kinase (1996) (0)
- The PI 3 kinase family - Diversity in substrate specificity and activation mechanisms. (1996) (0)
- CD4+CD25+Foxp3+ Regulatory T Cells Is Critical for the Function of δ p110Edge: The Phosphoinositide 3-Kinase (2013) (0)
- Tumor necrosis factor: Mechanisms of action and potential role in cancer treatment (1993) (0)
- Author Correction: PI3K inhibitors are finally coming of age (2021) (0)
- Tumor Necrosis Factor: Mechanism of Action and its Potential for Anticancer Therapy (1992) (0)
- Low dose of cancer drug improves overgrowth syndrome : lessons for cancer therapy ? (2018) (0)
- NFκB-Mediated Expression of Phosphoinositide 3-Kinase δ Is Critical for Mesenchymal Transition in Retinal Pigment Epithelial Cells (2023) (0)
- Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism (2017) (0)
- Cancer Cell Previews PI 3 K Regulatory Subunits Lose Control in Cancer (2009) (0)
- Vivo Invasiveness Correlates with Reduced Tumorigenicity and Reduced Expression of the Tumor Necrosis Factor Gene in Tumor Cells (2006) (0)
- Phosphoinositide 3-Kinases : p 110 Isoform-Specific Functions of Vanhaesebroeck (2008) (0)
- Idelalisib inhibits experimental proliferative vitroretinopathy (2022) (0)
- Insights into the biology of class I PI3K isoforms and translation to the clinic (2018) (0)
- B-1 B Cell Function , and Autoantibody ZoneNatural Antibody Production , Marginal Regulates δ Phosphoinositide 3-Kinase p 110 Witztum (2009) (0)
- Complexes PI 3 K { beta } Plays a Critical Role in Neutrophil Activation by Immune ` (2011) (0)
- PI 3K in the Immune System PI 3-Kinase in the Immune System (2003) (0)
- Title : Somatic Activating Mutations in Pik 3 ca Cause Sporadic Venous Malformations in Mice and Humans (2016) (0)
- Endothelial phosphoinositide 3-kinase-β inactivation confers protection from immune-mediated vascular injury. (2023) (0)
- Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency (2018) (0)
- Activated PI3-Kinase Delta Syndrome: Clinical, Radiological And Laboratory Features Of A Large Cohort. (2015) (0)
- Sensitization of T \ imor Cells to l \ imor Necrosis Factor Action by the Protein Kinase Inhibitor Staurosporine 1 (2006) (0)
- Vps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis (2019) (0)
- Genome Editing of Pik3cd Impedes Abnormal Retinal Angiogenesis. (2022) (0)
- 3rd Focused Meeting on PI3K Signalling and Disease (2007) (0)
- Abstract 16333: PI3Kα Has a Role in Myocardial Insulin Signaling and Recovery From Cre/Tamoxifen Cardiotoxicity, but is not Required for Normal Function in the Adult Mouse Heart (2014) (0)
- The mouse made easy (2005) (0)
- Regulation of Macrophage signal transduction by p110δ PI3K (2018) (0)
- Role of P110alpha isoform of class I PI3-kinases in platelet activation and functions (2015) (0)
- p110beta PI3K isoform regulates microcrystals phagocytosis and crystal- mediated inflammasome activation in autoinflammatory disease (2014) (0)
- Distinctive Functions of PI3K beta in Endothelial Cells and Cardiomyocytes in Response to Myocardial Infarction: Complications for Targeting PI3K beta in Myocardial Infarction Treatment (2016) (0)
- Abstract 80: PI3Kα Regulates Biomechanical Stress-induced Cytoskeletal Remodeling: A Critical Role of Gelsolin (2016) (0)
- ErratumPI3K Regulatory Subunits Lose Control in Cancer (2010) (0)
- Search for genetic variability of the phosphoinositide 3-kinase (P13-K) in late onset Alzheimer's disease (2000) (0)
- Abstract B22: Investigation of PTEN genotype-phenotype correlations in the PTEN hamartoma tumor syndrome (PHTS) using in vitro and in vivo approaches (2020) (0)
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