Ben Shen
#147,997
Most Influential Person Now
Researcher
Ben Shen's AcademicInfluence.com Rankings
Ben Shencomputer-science Degrees
Computer Science
#7572
World Rank
#7972
Historical Rank
Machine Learning
#2832
World Rank
#2867
Historical Rank
Artificial Intelligence
#3125
World Rank
#3171
Historical Rank
Database
#4619
World Rank
#4798
Historical Rank
Download Badge
Computer Science
Ben Shen's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science Stanford University
Similar Degrees You Can Earn
Why Is Ben Shen Influential?
(Suggest an Edit or Addition)Ben Shen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. (2013) (1360)
- Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin (2010) (782)
- Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
- Decoding Human Cytomegalovirus (2012) (533)
- Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution (2012) (515)
- Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms. (2003) (482)
- A New Golden Age of Natural Products Drug Discovery (2015) (453)
- Antitumor antibiotics: bleomycin, enediynes, and mitomycin. (2005) (434)
- Synthetic biology to access and expand nature's chemical diversity (2016) (369)
- A genomics-guided approach for discovering and expressing cryptic metabolic pathways (2003) (294)
- The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. (2000) (249)
- Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 (2002) (238)
- Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis (2003) (233)
- Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules. (2001) (183)
- Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. (2009) (173)
- Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. (2004) (158)
- Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. (2009) (154)
- Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. (2001) (150)
- Microbial genomics for the improvement of natural product discovery. (2006) (143)
- Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. (2007) (118)
- Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis. (1995) (116)
- Biosynthesis of Aromatic Polyketides (2000) (113)
- The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. (2005) (111)
- Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination (2010) (108)
- Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation (2010) (98)
- Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A. (1993) (97)
- Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. (2005) (96)
- A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. (2003) (96)
- Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation. (2003) (93)
- Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis (2011) (92)
- Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase (1992) (85)
- Biosynthesis of hybrid peptide-polyketide natural products. (2001) (85)
- Identification and Localization of the Gene Cluster Encoding Biosynthesis of the Antitumor Macrolactam Leinamycin in Streptomyces atroolivaceus S-140 (2002) (84)
- Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model (2003) (82)
- Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027. (2007) (82)
- Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. (1993) (79)
- Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. (2017) (79)
- Engineered Streptomyces platensis Strains That Overproduce Antibiotics Platensimycin and Platencin (2009) (79)
- Identification and Utility of FdmR1 as a Streptomyces Antibiotic Regulatory Protein Activator for Fredericamycin Production in Streptomyces griseus ATCC 49344 and Heterologous Hosts (2008) (78)
- The biosynthetic gene cluster for the anticancer drug bleomycin from Streptomyces verticillus ATCC15003 as a model for hybrid peptide–polyketide natural product biosynthesis (2001) (77)
- Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein (2000) (77)
- The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis. (2008) (76)
- Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase. (1996) (76)
- Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. (2012) (75)
- Signal Mimics Derived from a Metagenomic Analysis of the Gypsy Moth Gut Microbiota (2007) (74)
- Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender Units* (2010) (74)
- Biosynthesis of enediyne antitumor antibiotics. (2008) (74)
- Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003. (2002) (72)
- A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis (2009) (72)
- C-O Bond Formation by Polyketide Synthases (2002) (70)
- A proteogenomics approach integrating proteomics and ribosome profiling increases the efficiency of protein identification and enables the discovery of alternative translation start sites (2014) (69)
- A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis (2008) (68)
- Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. (2003) (67)
- Natural product drug discovery: the times have never been better. (2007) (65)
- Discovery of the leinamycin family of natural products by mining actinobacterial genomes (2017) (65)
- An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003. (2000) (63)
- Conversion of (2S)‐Arginine to (2S,3R)‐Capreomycidine by VioC and VioD from the Viomycin Biosynthetic Pathway of Streptomyces sp. Strain ATCC11861 (2004) (62)
- The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. (2007) (62)
- The Mechanism of MIO-Based Aminomutases in β-Amino Acid Biosynthesis (2007) (61)
- Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis (2006) (61)
- Strain Prioritization and Genome Mining for Enediyne Natural Products (2016) (61)
- Divergent synthesis of complex diterpenes through a hybrid oxidative approach (2020) (56)
- Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents (2003) (55)
- Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. (2009) (54)
- Engineered production of iso-migrastatin in heterologous Streptomyces hosts. (2009) (52)
- Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin. (2011) (52)
- Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery (2016) (52)
- The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides (1995) (52)
- Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase. (2011) (52)
- NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide. (2010) (51)
- Targeting Bacterial Genomes for Natural Product Discovery. (2019) (51)
- The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. (2006) (51)
- Biosynthesis of the β-Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring β-Amino Acyl-S-carrier Protein Intermediates (2005) (49)
- Chain Initiation in the Leinamycin-producing Hybrid Nonribosomal Peptide/Polyketide Synthetase from Streptomyces atroolivaceus S-140 (2007) (48)
- Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses (2007) (48)
- Structural and evolutionary relationships of “AT-less” type I polyketide synthase ketosynthases (2015) (47)
- The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. (2007) (47)
- Enediynes: Exploration of microbial genomics to discover new anticancer drug leads (2014) (47)
- Strain Prioritization for Natural Product Discovery by a High-Throughput Real-Time PCR Method (2014) (47)
- iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase* (2009) (46)
- The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. (2009) (45)
- Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks. (2007) (45)
- Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. (2006) (45)
- New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase. (2012) (45)
- Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning the Oxazolomycin Biosynthetic Gene Cluster from Streptomyces albus JA3453 (2006) (44)
- Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism (2008) (44)
- Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein. (2001) (44)
- Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes (2010) (43)
- Biosynthetic Potential-Based Strain Prioritization for Natural Product Discovery: A Showcase for Diterpenoid-Producing Actinomycetes (2014) (43)
- Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. (2005) (42)
- Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. (2017) (41)
- Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase (2014) (41)
- Genetic Localization and Molecular Characterization of the nonS Gene Required for Macrotetrolide Biosynthesis inStreptomyces griseus DSM40695 (2000) (41)
- Type I polyketide synthases that require discrete acyltransferases. (2009) (41)
- Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. (2005) (41)
- Characterization of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus Unveiling New Insights into Dialkylmaleic Anhydride and Polyketide Biosynthesis* (2008) (41)
- Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003. (1999) (39)
- SHP2 is a target of the immunosuppressant tautomycetin. (2011) (39)
- Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209 (2011) (38)
- Bleomycin Biosynthesis inStreptomyces verticillusATCC15003: A Model of Hybrid Peptide and Polyketide Biosynthesis☆☆☆★ (1999) (37)
- Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species (2015) (37)
- Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners. (2010) (37)
- Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains. (2014) (37)
- In Vivo Manipulation of the Bleomycin Biosynthetic Gene Cluster in Streptomyces verticillus ATCC15003 Revealing New Insights into Its Biosynthetic Pathway* (2008) (37)
- Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. (2011) (37)
- Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidation. (2007) (37)
- Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase (2016) (36)
- C-S bond cleavage by a polyketide synthase domain (2015) (36)
- The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins (2014) (36)
- Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. (2013) (35)
- Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. (1993) (35)
- Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. (2008) (35)
- Enediyne Biosynthesis and Self-Resistance: A Progress Report (1999) (34)
- Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. (2012) (33)
- Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine (2017) (33)
- Triple hydroxylation of tetracenomycin A2 to tetracenomycin C in Streptomyces glaucescens. Overexpression of the tcmG gene in Streptomyces lividans and characterization of the tetracenomycin A2 oxygenase. (1994) (32)
- A designer bleomycin with significantly improved DNA cleavage activity. (2012) (32)
- Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. (2019) (32)
- BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation. (2003) (32)
- Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600. (2009) (32)
- Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis. (2009) (31)
- Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. (2008) (31)
- Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion. (2015) (31)
- Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3β (2009) (30)
- Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. (2011) (30)
- Identification and characterization of a novel estrogenic ligand actinopolymorphol A. (2010) (29)
- Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space (2018) (29)
- Substrate Specificity of the Adenylation Enzyme SgcC1 Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027* (2006) (29)
- Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from Actinopolymorpha rutilus. (2010) (29)
- A Dedicated Phosphopantetheinyl Transferase for the Fredericamycin Polyketide Synthase from Streptomyces griseus* (2006) (28)
- Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234 (2018) (27)
- New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus. (2007) (27)
- Advances in polyketide synthase structure and function. (2008) (27)
- C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells. (2009) (26)
- (#Issue1)Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I, and J† (2013) (26)
- Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. (2013) (26)
- Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis. (2018) (26)
- Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O. (2000) (26)
- Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production. (2004) (26)
- Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation. (2008) (26)
- Biosynthetic Origin of the Ether Ring in Platensimycin. (2016) (25)
- Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis. (2011) (25)
- Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027 (2010) (25)
- Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues. (2006) (24)
- Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001 (2018) (24)
- Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6′-deoxy-bleomycin Z production (2018) (24)
- A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. (2015) (24)
- Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. (1993) (23)
- Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141 (2011) (23)
- Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus (2006) (23)
- Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts (2019) (23)
- Biosynthesis of antibiotic LL-C10037.alpha.: the steps beyond 3-hydroxyanthranilic acid (1989) (22)
- Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. (2008) (22)
- Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. (2007) (22)
- Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors (2012) (22)
- Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. (2009) (22)
- Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. (2009) (21)
- Structure and absolute stereochemistry of the epoxyquinol LL-C10037.alpha. and related metabolites from Streptomyces LL-C10037 (1990) (21)
- Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026 (2016) (21)
- Iterative type I polyketide synthases for enediyne core biosynthesis. (2009) (21)
- Macrotetrolide biosynthesis: a novel type II polyketide synthase. (2002) (20)
- Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. (2009) (20)
- Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules. (2003) (20)
- Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin* (2008) (20)
- Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis. (2012) (20)
- Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT–PCR (2011) (20)
- Multifaceted Modes of Action for the Glutarimide‐Containing Polyketides Revealed (2010) (19)
- Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. (2010) (19)
- Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate. (2010) (19)
- Opposite facial specificity for two hydroquinone epoxidases: (3-si,4-re)-2,5-dihydroxyacetanilide epoxidase from Streptomyces LL-C10037 and (3-re,4-si)-2,5-dihydroxyacetanilide epoxidase from Streptomyces MPP 3051. (1991) (19)
- In Vivo Investigation of the Roles of FdmM and FdmM1 in Fredericamycin Biosynthesis Unveiling a New Family of Oxygenases* (2009) (19)
- The missing C-17 O-methyltransferase in geldanamycin biosynthesis. (2011) (19)
- Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. (2016) (19)
- Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates (2021) (18)
- Cloning, Sequencing, and Heterologous Expression of the elmGHIJ Genes Involved in the Biosynthesis of the Polyketide Antibiotic Elloramycin from Streptomyces olivaceus Tü2353 (2001) (18)
- Characterization of FdmV as an Amide Synthetase for Fredericamycin A Biosynthesis in Streptomyces griseus ATCC 43944* (2010) (18)
- Leveraging a large microbial strain collection for natural product discovery (2019) (18)
- Resistance to Enediyne Antitumor Antibiotics by Sequestration. (2018) (17)
- Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin. (2018) (17)
- In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin. (2017) (17)
- Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. (2009) (17)
- Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway. (2018) (17)
- A new member of the 4-methylideneimidazole-5-one–containing aminomutase family from the enediyne kedarcidin biosynthetic pathway (2013) (16)
- Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues. (2017) (16)
- Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027. (2009) (16)
- Epoxyquinones from 2,5-dehydroxyacetanilide : opposite facial specificity in the epoxidation by enzymes from Streptomyces LL-C10037 and Streptomyces MPP 3051 (1991) (16)
- Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tü2353. (2001) (16)
- A Mutasynthetic Library of Platensimycin and Platencin Analogues. (2016) (15)
- Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. (2012) (15)
- Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) (2013) (15)
- Biosynthesis of thiocarboxylic acid-containing natural products (2018) (15)
- Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster. (2010) (15)
- Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus (2016) (15)
- Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. (2018) (15)
- Comparative Characterization of the Lactimidomycin and iso-Migrastatin Biosynthetic Machineries Revealing Unusual Features for Acyltransferase-less Type I Polyketide Synthases and Providing an Opportunity To Engineer New Analogues (2014) (15)
- Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog. (2010) (15)
- Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. (2013) (14)
- Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models. (2019) (14)
- Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme (2018) (14)
- Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. (2019) (14)
- Accessing Natural Products by Combinatorial Biosynthesis (2004) (14)
- Platensimycin-Encapsulated Poly(lactic-co-glycolic acid) and Poly(amidoamine) Dendrimers Nanoparticles with Enhanced Anti-Staphylococcal Activity in Vivo. (2020) (14)
- Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. (2018) (13)
- Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600 (2013) (13)
- The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis. (2007) (13)
- Progress in combinatorial biosynthesis for drug discovery. (2006) (13)
- Characterization of TnmH as an O-Methyltransferase Revealing In-sights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy to Prepare Antibody-Tiancimycin Conjugates. (2020) (13)
- Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis. (2018) (13)
- Yangpumicins F and G, Enediyne Congeners from Micromonospora yangpuensis DSM 45577. (2019) (13)
- Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins (2016) (13)
- Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells. (2017) (12)
- Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. (2019) (12)
- Platensimycin-Encapsulated Liposomes or Micelles as Biosafe Nanoantibiotics Exhibited Strong Antibacterial Activities against Methicillin-Resistant Staphylococcus aureus Infection in Mice. (2020) (12)
- Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. (2009) (12)
- Neaumycin: a new macrolide from Streptomyces sp. NEAU-x211. (2012) (12)
- Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase–Polyketide Synthase Interface for Leinamycin Biosynthesis (2016) (12)
- Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. (2013) (11)
- Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo. (2019) (11)
- Adipostatins A–D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites (2015) (11)
- BlmB and TlmB Provide Resistance to the Bleomycin Family of Antitumor Antibiotics by N-Acetylating Metal-Free Bleomycin, Tallysomycin, Phleomycin, and Zorbamycin (2014) (11)
- Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis (2014) (11)
- Enediyne natural products: biosynthesis and prospect towards engineering novel antitumor agents. (2003) (11)
- Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases (2018) (10)
- The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. (2018) (10)
- Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers. (2018) (10)
- Combinatorial Biosynthesis of Anticancer Natural Products (2005) (10)
- Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity. (2018) (10)
- Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement (2016) (10)
- Improved production of the tallysomycin H-1 in Streptoalloteichus hindustanus SB8005 strain by fermentation optimization (2010) (10)
- A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis. (2017) (10)
- Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. (2018) (10)
- A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin. (2017) (9)
- Crystal Structure of SgcJ, An NTF2-Like Superfamily Protein Involved in Biosynthesis of the 9-Membered Enediyne Antitumor Antibiotic C-1027 (2016) (9)
- Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453. (2008) (9)
- Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis (2017) (9)
- Germicidins H–J from Streptomyces sp. CB00361 (2016) (9)
- Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids. (2018) (9)
- The discovery and development of microbial bleomycin analogues (2018) (9)
- Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. (2015) (9)
- Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. (2005) (8)
- 4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis. (2012) (8)
- Iso-migrastatin titer improvement in the engineered Streptomyces lividans SB11002 strain by optimization of fermentation conditions (2010) (8)
- Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin. (2015) (8)
- The genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cells. (2018) (8)
- Discovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686. (2019) (7)
- Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. (2013) (7)
- PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates. (2018) (7)
- Tandem acyl carrier protein domains in polyunsaturated fatty acid synthases. (2009) (7)
- Expanding nature's chemical repertoire through metabolic engineering and biocatalysis. (2012) (7)
- Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity. (2018) (7)
- Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues. (2016) (7)
- Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. (2012) (7)
- Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis (2013) (7)
- The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance. (2014) (6)
- Biosynthesis of Enediyne Natural Products (2019) (6)
- Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters. (2005) (6)
- New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883 (2016) (6)
- Cytochrome P450 Hydroxylase TnmL Catalyzing Sequential Hydroxylation with an Additional Proofreading Activity in Tiancimycin Biosynthesis. (2021) (6)
- The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2R)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis. (2020) (5)
- Cryptic sulfur incorporation in thioangucycline biosynthesis. (2021) (5)
- Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA. (2018) (5)
- Functional Characterization of tlmK Unveiling Unstable Carbinolamide Intermediates in the Tallysomycin Biosynthetic Pathway* (2009) (5)
- The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery (2013) (5)
- Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis (2021) (5)
- Engineered production and evaluation of 6′-deoxy-tallysomycin H-1 revealing new insights into the structure–activity relationship of the anticancer drug bleomycin (2017) (5)
- FEN1 (flap structure-specific endonuclease 1) (2011) (5)
- Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation. (2016) (5)
- Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid (2017) (4)
- Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase (2021) (4)
- PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases. (2020) (4)
- P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. (2018) (4)
- Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases. (2012) (4)
- Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin (2005) (4)
- Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production (2021) (4)
- Crystallization and preliminary X-ray analysis of tetracenomycin A2 oxygenase: a flavoprotein hydroxylase involved in polyketide biosynthesis. (2000) (3)
- Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA. (2021) (3)
- Polyketide Synthases: Enzyme Complexes and Multifunctional Proteins Directing the Biosynthesis of Bacterial Metabolites from Fatty Acids (1992) (3)
- The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. (2020) (3)
- Molecular Genetics and Biochemistry of Type II Polyketide Synthases from the Perspective of Tetracenomycin C Biosynthesis in Streptomyces glaucescens. (1992) (3)
- Stereoselective functionalization of platensimycin and platencin by sulfa-Michael/aldol reactions. (2019) (2)
- Biosynthesis of Pharmaceutical Natural Products and Their Pathway Engineering (2012) (2)
- Harnessing the Biocatalytic Potential of PtmO6, an α-Ketoglutarate-Dependent Dioxygenase from Platensimycin Biosynthesis, for the Chemoenzymatic Synthesis of Highly Oxidized ent-Kaurane Diterpenes (2019) (2)
- Functional Characterization of Cytochrome P450 Hydroxylase YpmL in Yangpumicin A Biosynthesis and Its Application for Anthraquinone-Fused Enediyne Structural Diversification. (2022) (2)
- The Role of Combinatorial Biosynthesis in Natural Products Discovery (2017) (2)
- Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D (2017) (2)
- Thermolysis of Iso-Migrastatin and Its Congeners via [3,3]-Sigmatropic Rearrangement: A New Route to the Synthesis of Migrastatin and Its Analogues (2008) (1)
- Faculty Opinions recommendation of Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. (2002) (1)
- Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis. (2022) (1)
- A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases. (2019) (1)
- Professor Emeritus C Richard Hutchinson (10 October 1943–5 January 2010) (2010) (1)
- Hybrid Peptide–Polyketide Natural Product Biosynthesis (2020) (1)
- Special issue of The Journal of Antibiotics dedicated to the late Professor C Richard Hutchinson (2011) (1)
- Introduction to the special issue: “Natural Product Discovery and Development in the Genomic Era: 2021” (2021) (1)
- The structure of SgcE10, the ACP-polyene thioesterase involved in C-1027 biosynthesis (2012) (1)
- Tautomycetin suppresses carcinoid tumor growth and bioactive hormone production through inactivation of glycogen synthase kinase-3 beta (2008) (0)
- Faculty Opinions recommendation of Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. (2002) (0)
- Biosynthetic Studies of the Antibiotic Uncialamycin (2017) (0)
- Diversified and multiple antibiotic pathway genes and combinatorial perspectives in Streptomyces (2005) (0)
- The discovery and development of microbial bleomycin analogues (2018) (0)
- Microbial genomics and strain prioritization to streamline natural product discovery (2015) (0)
- Exploring Biocatalysts for Stereoselective Synthesis by the Investigation of the Biosynthesis of Natural Products (2013) (0)
- Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234 (2018) (0)
- Faculty Opinions recommendation of Biomimetic synthesis and optimization of cyclic peptide antibiotics. (2002) (0)
- Purification andCharacterization oftheAcylCarrier Protein ofthe Streptomyces glaucescens Tetracenomycin CPolyketide Synthase (1992) (0)
- Crystal structure of PtmU3 complexed with PTM substrate (2019) (0)
- Cycloheximide and Congeners as Inhibitors of Eukaryotic Protein Synthesis from Endophytic Actinomycetes Streptomyces sps. YIM56132 and YIM56141. (2011) (0)
- Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6′-deoxy-bleomycin Z production (2017) (0)
- The crystal structure of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus. (2012) (0)
- Faculty Opinions recommendation of Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine. (2002) (0)
- Structure and Absolute Stereochemistry of the Epoxyquinol LL-ClOO 37 a and Related Metabolites from Streptomyces LLC 10037 (2001) (0)
- Acyl-CoA synthetase PtmA2 from Streptomyces platensis in complex with SBNP468 ligand (2017) (0)
- Purification and Characterization of the Acyl Carrier Protein of the Streptomyces (0)
- Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes with FMN bound at 2.05 A resolution (2018) (0)
- A comparison of cellular DNA repair rates of different cell lines using the TUNEL assay (2006) (0)
- Crystal structure of SgcC5 protein from Streptomyces globisporus (complex with (R)-(-)-1-(2-naphthyl)-1,2-ethanediol and sucrose) (2015) (0)
- Faculty Opinions recommendation of A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. (2002) (0)
- Metabolic approach for regulation of IL-1 beta in vivo. (1995) (0)
- The Role of Evolution in the Discovery of New Drugs and Chemicals (2009) (0)
- Faculty Opinions recommendation of Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics. (2002) (0)
- Crystal structure of TnmH (2019) (0)
- Biosynthesis of Antibiotic LLC 10037 a : The Steps beyond 3-Hydroxy anthranilic Acid (2001) (0)
- Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis (2013) (0)
- Biosynthesis of thiocarboxylic acid-containing natural products (2018) (0)
- Streptomyces platensis isomigrastatin ketosynthase domain MgsE KS3 (2014) (0)
- MIO-containing aminomutases for α- to β-amino acids. (2021) (0)
- Enantioselective Synthesis of α‐Oxy Amides via Umpolung Amide Synthesis. (2013) (0)
- Solution structure of mitochondrial Tim23 channel in complex with a signaling peptide (2020) (0)
- Polymorphic variants of human DNA glycosylase NEIL2 and lung cancer susceptibility (2011) (0)
- Crystal structure of ZbmA, the zorbamycin binding protein from Streptomyces flavoviridis (2013) (0)
- Crystal structure of PtmU3 complexed with PTN substrate (2019) (0)
- Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement (2016) (0)
- UWS Academic Portal Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D (2016) (0)
- Crystal structure of UcmS2 (2019) (0)
- Acyl-CoA synthetase PtmA2 from Streptomyces platensis in complex with SBNP465 ligand (2017) (0)
- Staurosporine produced by marine-derived actinomycete Streptomyces roseoflavus MB-97 isolated from coastal sediment (2008) (0)
- Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes, apo form at 2.6 A resolution (P212121) (2018) (0)
- Faculty Opinions recommendation of Evidence for a monomeric structure of nonribosomal Peptide synthetases. (2002) (0)
- Streptomyces globisporus C-1027 9-membered enediyne conserved protein SgcE6 (2012) (0)
- LnmX protein, a putative GlcNAc-PI de-N-acetylase from Streptomyces atroolivaceus (2015) (0)
- Crystal structure of SgcJ protein from Streptomyces carzinostaticus (2013) (0)
- Crystal structure of TnmS3 in complex with riboflavin (2018) (0)
- Crystal structure of TnmS1, an antibiotic binding protein from Streptomyces sp. CB03234 (2018) (0)
- Ensemble refinement of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus. (2014) (0)
- Streptomyces globisporus C-1027 NADH:FAD oxidoreductase SgcE6 (2012) (0)
- Faculty Opinions recommendation of Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. (2002) (0)
- A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products. (2023) (0)
- A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases (2019) (0)
- Crystal structure of apo PtmU3 (2019) (0)
- Streptomyces globisporus C-1027 FAD dependent (S)-3-chloro-β-tyrosine-S-SgcC2 C-5 hydroxylase SgcC apo form (2014) (0)
- Crystal structure of TnmS3 in complex with tiancimycin (TNM B) (2018) (0)
- Crystal structure of LnmF protein from Streptomyces amphibiosporus (2014) (0)
- Faculty Opinions recommendation of The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. (2002) (0)
- Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase (2021) (0)
- Faculty Opinions recommendation of PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. (2003) (0)
- Crystal structure of tallysomycin biosynthesis protein TlmII (2012) (0)
- Acyl-CoA synthetase PtmA2 from Streptomyces platensis (2015) (0)
- inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance q (2014) (0)
- Identifi cation of antifungal natural products via Saccharomyces cerevisiae bioassay : insights into macrotetrolide drug spectrum , potency and mode of action (2013) (0)
- Crystal structure of the I-SmaMI LAGLIDADG homing endonuclease bound to cleaved DNA (2014) (0)
- Structural and evolutionary relationships of ketosynthase domains from modular polyketide synthases (2015) (0)
- Crystal structure of the LnmA cytochrome P450 hydroxylase from the leinamycin biosynthetic pathway of Streptomyces atroolivaceus S-140 at 1.9 A resolution (2015) (0)
- Crystal structure of TnmS3 in complex with tiancimycin (2018) (0)
- The Isolation of Pyrroloformamide Congeners and Characterization of Its Biosynthetic Gene Cluster from Streptomyces sp. CB02980 Revealed a Unified Mechanism for Dithiolopyrrolone Biosynthesis (2019) (0)
- Faculty Opinions recommendation of Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster. (2003) (0)
- LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics (1990) (0)
- Microbial genomics: New opportunities for natural product biosynthesis, engineering, and drug discovery (2015) (0)
- Acyl-CoA synthetase PtmA2 from Streptomyces platensis in complex with SBNP663 ligand (2017) (0)
- Faculty Opinions recommendation of Iterative chain elongation by a pikromycin monomodular polyketide synthase. (2003) (0)
- Crystal structure of the TtnD decarboxylase from the tautomycetin biosynthesis pathway of Streptomyces griseochromogenes with apo form at 1.83 A resolution (I222) (2018) (0)
- REV Hybrid Peptide Polyketide Natu Prospects toward Engin (2001) (0)
- Crystal structure of TnmH in complex with SAM (2019) (0)
- Erythronolides H (I) and I (II), New Erythromycin Congeners from a New Halophilic Actinomycete Actinopolyspora sp. YIM90600. (2009) (0)
- Enzyme chemistry shows way to new antimicrobials Newsdesk (2002) (0)
- Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. (2023) (0)
- Cloning and Characterization of the Bleomycin Biosynthetic Gene Cluster from Streptomyces verticillus ATCC 150031 (0)
- Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins (2015) (0)
- Streptomcyes albus JA3453 oxazolomycin ketosynthase domain OzmH KS7 (2014) (0)
- Natural products by synthetic biology and microbial engineering (2018) (0)
- Analysis of the Gypsy Moth Gut Microbiota . Appl . 2007 . Signal Mimics Derived from a Metagenomic (2007) (0)
- ent-Copalyl diphosphate synthase from Streptomyces platensis (2015) (0)
- Structure of BlmI, a type-II acyl-carrier-protein from Streptomyces verticillus involved in bleomycin biosynthesis (2012) (0)
- Streptomyces globisporus C-1027 NADH:FAD oxidoreductase SgcE6 in complex with NAD and FAD fragments (2014) (0)
- Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. (2023) (0)
- Innovations in strain prioritization to streamline natural product discovery (2014) (0)
- Cryptic Sulfur Incorporation in Thioangucycline Biosynthesis (2021) (0)
- Crystal structure of the I-LtrWI LAGLIDADG homing endonuclease bound to target DNA. (2014) (0)
- Crystal structure of SgcC5 protein from Streptomyces globisporus (apo form) (2015) (0)
- Crystal structure of TnmS3, an antibiotic binding protein from Streptomyces sp. CB03234 (2018) (0)
- Crystal Structure of Dehydrogenase from Streptomyces platensis (2015) (0)
- Crystal structure of TnmS3 in complex with TNM C (2018) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Ben Shen?
Ben Shen is affiliated with the following schools:
