Benedikt Kessler
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Benedikt Kesslerchemistry Degrees
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Benedikt Kesslerbiology Degrees
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Chemistry Biology
Benedikt Kessler's Degrees
- PhD Biochemistry University of Zurich
- Masters Chemistry University of Zurich
- Bachelors Chemistry University of Zurich
Why Is Benedikt Kessler Influential?
(Suggest an Edit or Addition)According to Wikipedia, Benedikt Kessler is a Swiss researcher and academic. He is Professor of Biochemistry and Mass Spectrometry at the Target Discovery Institute, University of Oxford. Kessler's research has been focused on ubiquitin and protease biology. Some of his work has dealt with defining the molecular signatures in human disease processes and accelerating target discovery in translational research. He holds one patent.
Benedikt Kessler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase (2004) (1920)
- Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (2020) (884)
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 (2018) (867)
- Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. (2004) (604)
- Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014) (602)
- Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. (2002) (501)
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling (2011) (491)
- A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 (2001) (472)
- A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. (2012) (466)
- Arginine methylation regulates the p53 response (2008) (447)
- KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands (2012) (411)
- Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing (2009) (377)
- New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. (2010) (370)
- Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo (2009) (357)
- Colonic epithelial cell diversity in health and inflammatory bowel disease (2019) (339)
- Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (2011) (317)
- Neuronal loss and brain atrophy in mice lacking cathepsins B and L (2002) (304)
- Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates (2015) (255)
- A Single Protease, Apg4B, Is Specific for the Autophagy-related Ubiquitin-like Proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L* (2003) (252)
- Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib (2005) (250)
- Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming (2011) (248)
- Molecular basis of USP7 inhibition by selective small-molecule inhibitors (2017) (248)
- A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. (2005) (246)
- Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status (2011) (231)
- Identification of the target self-antigens in reperfusion injury (2006) (229)
- Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication (2007) (210)
- 53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ (2018) (207)
- Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor* (2007) (206)
- Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne (2016) (201)
- Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy (2013) (200)
- Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. (2010) (199)
- Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins (2004) (199)
- Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway* (2010) (196)
- Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity (2016) (192)
- Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue (2014) (189)
- Arginine methylation controls growth regulation by E2F‐1 (2012) (188)
- Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. (2004) (184)
- Structural basis and specificity of human otubain 1-mediated deubiquitination. (2009) (181)
- Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. (2001) (169)
- Identification of Proteins Associated with Murine Cytomegalovirus Virions (2004) (163)
- Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. (2003) (162)
- Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair (2016) (158)
- Novel MMP-9 Substrates in Cancer Cells Revealed by a Label-free Quantitative Proteomics Approach*S (2008) (154)
- Protein sequences bound to mineral surfaces persist into deep time (2016) (151)
- Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. (2013) (148)
- Activation of the Lectin Pathway by Natural IgM in a Model of Ischemia/Reperfusion Injury1 (2006) (147)
- Control of cross‐presentation during dendritic cell maturation (2004) (145)
- Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells. (2005) (145)
- Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency (2013) (145)
- Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors* (2011) (142)
- QuaNCAT: quantitating proteome dynamics in primary cells (2013) (140)
- Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase* (2004) (138)
- Ubiquitin ligase ARF‐BP1/Mule modulates base excision repair (2009) (135)
- Comparative evaluation of label‐free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline (2011) (133)
- Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. (2012) (131)
- ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage (2012) (129)
- Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia (2015) (127)
- Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. (2000) (125)
- Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins*S⃞ (2009) (125)
- Discovery of Candidate Serum Proteomic and Metabolomic Biomarkers in Ankylosing Spondylitis* (2011) (124)
- Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche. (2016) (122)
- SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling (2016) (121)
- The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity (2012) (120)
- Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients (2020) (120)
- Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. (2013) (117)
- CPFP: a central proteomics facilities pipeline (2010) (114)
- Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation (2019) (113)
- Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis (2015) (111)
- Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix (2018) (111)
- Identification of distinct circulating exosomes in Parkinson's disease (2015) (108)
- Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity (2007) (107)
- Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy (2014) (106)
- The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement. (1998) (106)
- Gel-aided sample preparation (GASP)—A simplified method for gel-assisted proteomic sample generation from protein extracts and intact cells (2015) (105)
- Gene expression analysis of B‐lymphoma cells resistant and sensitive to bortezomib * (2006) (104)
- PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes (2017) (100)
- DNA Modification under Mild Conditions by Suzuki–Miyaura Cross-Coupling for the Generation of Functional Probes** (2013) (99)
- USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β. (2011) (98)
- OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation (2014) (96)
- A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis (2009) (95)
- Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1 (2014) (94)
- Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis (2018) (94)
- Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease (2016) (93)
- RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes (2016) (92)
- Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein (2011) (89)
- Elevation of Intact and Proteolytic Fragments of Acute Phase Proteins Constitutes the Earliest Systemic Antiviral Response in HIV-1 Infection (2010) (89)
- Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases (2011) (88)
- Detection of Multiple Autoantibodies in Patients with Ankylosing Spondylitis Using Nucleic Acid Programmable Protein Arrays* (2010) (86)
- Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes (2013) (85)
- Ultra-fast tandem mass spectrometry scanning combined with monolithic column liquid chromatography increases throughput in proteomic analysis. (2006) (84)
- Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA–B27 (2014) (81)
- Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination (2009) (81)
- Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs (2016) (81)
- Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1. (2010) (81)
- Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production. (1998) (79)
- Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis. (2018) (78)
- CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer (2015) (78)
- PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications (2011) (75)
- The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels (2011) (75)
- E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes* (2011) (74)
- Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads (2018) (74)
- Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis (2017) (73)
- Small‐Molecule Inhibitors and Probes for Ubiquitin‐ and Ubiquitin‐Like‐Specific Proteases (2005) (73)
- Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles (2008) (72)
- Iron load and redox stress in skeletal muscle of aged rats (2007) (71)
- Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules. (2005) (69)
- DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair. (2016) (69)
- MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis (2019) (68)
- Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains (2011) (68)
- Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells (2020) (67)
- Proteomic Analysis of Human Adipose Tissue After Rosiglitazone Treatment Shows Coordinated Changes to Promote Glucose Uptake (2010) (67)
- Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway (2008) (66)
- Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. (2004) (65)
- Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes. (2013) (64)
- USP4 Auto-Deubiquitylation Promotes Homologous Recombination (2015) (64)
- Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor* (2010) (64)
- Interaction of Hydroxylated Collagen IV with the von Hippel-Lindau Tumor Suppressor* (2007) (64)
- Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. (2010) (63)
- Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways (2014) (62)
- Divergent allocation of sperm and the seminal proteome along a competition gradient in Drosophila melanogaster (2019) (62)
- Post‐translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion (2010) (62)
- Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis (2015) (62)
- The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis (2019) (60)
- Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU. (2002) (60)
- Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response (2016) (59)
- Protein arginine methylation: a prominent modification and its demethylation (2017) (58)
- Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). (2011) (57)
- Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability (2011) (57)
- Effects of Epitope Modification on T Cell Receptor–Ligand Binding and Antigen Recognition by Seven H-2Kd–restricted Cytotoxic T Lymphocyte Clones Specific for a Photoreactive Peptide Derivative (1997) (56)
- Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine–serine-rich (RS) domains of SR- and SR-like proteins (2014) (56)
- DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets (2016) (54)
- Defining the HLA class I‐associated viral antigen repertoire from HIV‐1‐infected human cells (2015) (54)
- Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes (2017) (53)
- Discovery and Validation of Biomarkers to Guide Clinical Management of Pneumonia in African Children (2014) (53)
- Mitochondrial proteome analysis reveals altered expression of voltage dependent anion channels in pancreatic β-cells exposed to high glucose (2010) (51)
- TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts (2020) (50)
- OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo (2015) (50)
- Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7. (2007) (50)
- The Succinated Proteome of FH-Mutant Tumours (2014) (49)
- Ubiquitin - omics reveals novel networks and associations with human disease. (2013) (49)
- Debridement and implant retention in the management of hip periprosthetic joint infection: OUTCOMES FOLLOWING GUIDED AND RAPID TREATMENT AT A SINGLE CENTRE (2017) (48)
- Mapping protein interactions of sodium channel NaV1.7 using epitope‐tagged gene‐targeted mice (2017) (48)
- USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7 (2019) (47)
- USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation (2020) (47)
- A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. (2011) (47)
- Functional Proteomics of the Active Cysteine Protease Content in Drosophila S2 Cells* (2003) (46)
- HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. (2012) (46)
- A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome. (2007) (46)
- SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development (2016) (45)
- LMP2 expression and proteasome activity in NOD mice (2000) (44)
- Tyrosine dephosphorylation is required for Bak activation in apoptosis (2010) (44)
- Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster* (2018) (44)
- Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling (2020) (44)
- Urinary peptide profiling identifies a panel of putative biomarkers for diagnosing and staging endometriosis. (2011) (43)
- Optimizing 2D gas chromatography mass spectrometry for robust tissue, serum and urine metabolite profiling (2017) (43)
- Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection (2020) (43)
- Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome. (2003) (42)
- Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress (2012) (40)
- z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress (2006) (40)
- Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats (2004) (40)
- Immunodominance of cytotoxic T lymphocyte epitopes co‐injected in vivo and modulation by interleukin‐12 (1996) (39)
- A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance (2017) (39)
- Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis (2014) (39)
- Profiling Ubiquitin Linkage Specificities of Deubiquitinating Enzymes with Branched Ubiquitin Isopeptide Probes (2012) (37)
- MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation. (2002) (36)
- Free IL-12p40 Monomer Is a Polyfunctional Adaptor for Generating Novel IL-12–like Heterodimers Extracellularly (2014) (36)
- Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability (2015) (36)
- Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. (2004) (35)
- Label-free Quantitative Proteomics Reveals Differentially Regulated Proteins Influencing Urolithiasis* (2011) (35)
- A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors (2013) (34)
- E2F1 proteolysis via SCF‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition (2019) (34)
- miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration (2017) (34)
- Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells (2015) (34)
- Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics (2019) (34)
- The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. (2013) (33)
- Association of Distinct Fine Specificities of Anti−Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis (2017) (33)
- A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes (2018) (33)
- E3 Ligase cIAP2 Mediates Downregulation of MRE11 and Radiosensitization in Response to HDAC Inhibition in Bladder Cancer. (2017) (32)
- Detection of ubiquitin–proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development☆ (2012) (32)
- Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion (2018) (32)
- Ubiquitomics: An Overview and Future (2020) (31)
- The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks (2021) (31)
- Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors (2019) (31)
- The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes (2013) (31)
- The identification of archaeological eggshell using peptide markers (2017) (31)
- Immunopeptidomic Profiling of HLA‐A2‐Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens (2018) (30)
- Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows (2018) (30)
- Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells (2008) (30)
- A Novel Role for Triglyceride Metabolism in Foxp3 Expression (2019) (30)
- Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes (2016) (29)
- The why and how of amino acid analytics in cancer diagnostics and therapy. (2017) (29)
- Pathways Accessory to Proteasomal Proteolysis Are Less Efficient in Major Histocompatibility Complex Class I Antigen Production* (2003) (29)
- Characterization of exosomes in peritoneal fluid of endometriosis patients (2020) (29)
- Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. (2017) (29)
- The Human Otubain2-Ubiquitin Structure Provides Insights into the Cleavage Specificity of Poly-Ubiquitin-Linkages (2015) (29)
- β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression (2018) (29)
- A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN (2017) (28)
- Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome (2018) (27)
- The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases (2018) (27)
- Regulation of the endosomal SNX27-retromer by OTULIN (2019) (27)
- CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation (2017) (27)
- Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection (2011) (26)
- Plasma degradome affected by variable storage of human blood (2016) (26)
- Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable in Drosophila (2020) (26)
- Mechanisms by which Porphyromonas gingivalis evades innate immunity (2017) (26)
- UFLC‐Derived CSF Extracellular Vesicle Origin and Proteome (2018) (25)
- Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7 (2017) (24)
- Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily. (2008) (24)
- Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy. (2017) (24)
- The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo (2013) (24)
- Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors (2000) (24)
- A quantitative label-free analysis of the extracellular proteome of human supraspinatus tendon reveals damage to the pericellular and elastic fibre niches in torn and aged tissue (2017) (23)
- BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions (2019) (23)
- Two birds with one stone: Doing metabolomics with your proteomics kit (2013) (23)
- Molecular insights into an ancient form of Paget’s disease of bone (2019) (23)
- Role of CD8 in Aberrant Function of Cytotoxic T Lymphocytes (1997) (23)
- Renal cyst formation in Fh 1-deficient mice is independent of the Hif / Phd pathway (2011) (23)
- Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs (2019) (23)
- An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress (2020) (23)
- The Antiviral Efficacy of HIV-Specific CD8+ T-Cells to a Conserved Epitope Is Heavily Dependent on the Infecting HIV-1 Isolate (2011) (22)
- The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage (2018) (22)
- ATM and Chk2 kinase target the p53 cofactor Strap (2008) (22)
- Quantitative Proteomics Identification of Seminal Fluid Proteins in Male Drosophila melanogaster. (2019) (22)
- Human Platelet Protein Ubiquitylation and Changes following GPVI Activation (2018) (22)
- Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation* (2011) (21)
- Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218) (2014) (21)
- Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities (2021) (21)
- Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates (2016) (21)
- First Report on Ex vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion. (2020) (21)
- The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum (2015) (21)
- Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells (2019) (21)
- Detection of BK virus in urine from renal transplant subjects by mass spectrometry (2012) (21)
- Proteomic identification of host and parasite biomarkers in saliva from patients with uncomplicated Plasmodium falciparum malaria (2012) (20)
- Hypoxia metabolism in ageing (2015) (20)
- Expanding the yeast protein arginine methylome (2015) (20)
- Using an Integrated ‐Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death (2016) (20)
- CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis (2020) (20)
- FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment (2018) (19)
- A Pivotal Heme-transfer Reaction Intermediate in Cytochrome c Biogenesis* (2011) (19)
- Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP (2020) (19)
- p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation (2021) (19)
- Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates. (2010) (19)
- Proteomic analysis reveals a proteolytic feedback loop in murine seminal fluid (2013) (18)
- USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma (2020) (18)
- Protein Profiling in Hepatocellular Carcinoma by Label-Free Quantitative Proteomics in Two West African Populations (2013) (18)
- Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells (2019) (18)
- TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism. (2016) (17)
- A novel cytosolic class I antigen‐processing pathway for endoplasmic‐reticulum‐targeted proteins (2007) (16)
- T Cell Recognition of Hapten (1999) (16)
- Urine recirculation prolongs normothermic kidney perfusion via more optimal metabolic homeostasis—a proteomics study (2020) (16)
- Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism (2019) (16)
- PfHPRT: a new biomarker candidate of acute Plasmodium falciparum infection. (2013) (16)
- FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration (2018) (16)
- Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein (2018) (16)
- Modls: Post-translational modification localization scoring with automatic specificity expansion (2012) (16)
- A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes (2018) (16)
- Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib. (2016) (16)
- Putting proteomics on target: activity-based profiling of ubiquitin and ubiquitin-like processing enzymes (2006) (16)
- OS045. Multi-dimensional protein identification technology analysis of syncytiotrophoblast vesicles released from perfused preeclampsia placentas. (2012) (16)
- The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins (2018) (15)
- Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity (2020) (15)
- Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes (2017) (15)
- GOAT – A simple LC-MS/MS gradient optimization tool (2014) (14)
- Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. (2014) (14)
- Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP. (2016) (14)
- Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains. (2016) (14)
- Proteomic profiling of the plasma of Gambian children with cerebral malaria (2018) (14)
- A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption (2017) (14)
- Design, Synthesis and Characterization of Covalent KDM5 Inhibitors (2018) (14)
- Proteomic changes in response to crystal formation in Drosophila Malpighian tubules (2016) (13)
- Comparison of Neutralizing Antibody Responses Elicited from Highly Diverse Polyvalent Heterotrimeric HIV-1 gp140 Cocktail Immunogens versus a Monovalent Counterpart in Rhesus Macaques (2014) (13)
- Fluorescence-based active site probes for profiling deubiquitinating enzymes. (2012) (13)
- The deubiquitylase USP9X controls ribosomal stalling (2020) (13)
- P17-28 LB. The antiviral efficacy of HIV-specific CD8+ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate (2009) (13)
- Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation (2021) (13)
- A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer (2020) (12)
- An Activity‐Based Probe Targeting Non‐Catalytic, Highly Conserved Amino Acid Residues within Bromodomains (2018) (12)
- Integrated Physiological and Biochemical Assessments for the Prediction of Growth of Abdominal Aortic Aneurysms in Humans. (2018) (12)
- Bioorthogonal Organic Chemistry in Living Cells: Novel Strategies for Labeling Biomolecules (2005) (12)
- Snapin promotes HIV‐1 transmission from dendritic cells by dampening TLR8 signaling (2017) (12)
- Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase (2014) (11)
- Immunodominance complexity: lessons yet to be learned from dominant T cell responses to SARS-COV-2 (2021) (11)
- Integrated Plasma and Tissue Proteomics Reveals Attractin Release by Intraluminal Thrombus of Abdominal Aortic Aneurysms and Improves Aneurysm Growth Prediction in Humans (2020) (11)
- Glutamate receptor delta2 serum antibodies in paediatric opsoclonus myoclonus ataxia syndrome (2018) (11)
- The Chemoselective One‐Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine (2011) (10)
- ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context (2020) (10)
- Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function (2017) (10)
- Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions (2020) (10)
- [Tooth extraction under medication with acetylsalicylic acid]. (2006) (9)
- Assessing the Quality and Reproducibility of a Proteomic Platform for Clinical Stroke Biomarker Discovery (2010) (9)
- The presence of prolines in the flanking region of an immunodominant HIV‐2 gag epitope influences the quality and quantity of the epitope generated (2015) (9)
- Regulation of SUMO2 target proteins by the proteasome in human cells exposed to replication stress. (2015) (9)
- In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor. (2009) (8)
- The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1 (2021) (8)
- Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD 40 ligand from helper T cells (2019) (8)
- Applications for Chemical Probes of Proteolytic Activity (2004) (8)
- Cks1 Activates Transcription by Binding to the Ubiquitylated Proteasome (2010) (7)
- Dia2 Controls Transcription by Mediating Assembly of the RSC Complex (2011) (7)
- Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases (2019) (7)
- Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo (2015) (7)
- Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19 (2022) (7)
- Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation (2021) (7)
- Characterization of in vivo expanded OspA-specific human T-cell clones. (2005) (7)
- Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. (2011) (6)
- Deacetylation Inhibition Reverses PABPN1-Dependent Muscle Wasting (2019) (6)
- Proteomic analysis of machine perfusion solution from brain dead donor kidneys reveals that elevated complement, cytoskeleton and lipid metabolism proteins are associated with 1‐year outcome (2021) (6)
- Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells (2020) (6)
- Value of lipocalin 2 as a potential biomarker for bacterial meningitis (2020) (6)
- Subclinical Changes in Deceased Donor Kidney Proteomes Are Associated With 12-month Allograft Function Posttransplantation—A Preliminary Study (2019) (5)
- Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes (2021) (5)
- Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity (2020) (5)
- Challenges ahead for mass spectrometry and proteomics applications in epigenetics. (2010) (5)
- Conformational plasticity of the ULK3 kinase domain. (2021) (5)
- Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation (2018) (5)
- Proteomic profiling of the brain of mice with experimental cerebral malaria. (2017) (5)
- The Ugi Four-Component Reaction Enables Expedient Synthesis and Comparison of Photoaffinity Probes. (2014) (5)
- Genetic Control of Differential Acetylation in Diabetic Rats (2014) (5)
- Subclinical effects of remote ischaemic conditioning in human kidney transplants revealed by quantitative proteomics (2020) (5)
- Phosphorylation Induces Structural Changes in the Autographa californica Nucleopolyhedrovirus P10 Protein (2017) (4)
- Ejaculate deterioration with male age, and its amelioration in Drosophila (2019) (4)
- The deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1. (2020) (4)
- From herbal small RNAs to one medicine (2019) (4)
- Lipocalin-2 is a Sensitive and Specific Marker of Bacterial Infection in Children (2019) (4)
- Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation (2019) (4)
- Ataxin-3 links NOD2 and TLR2 mediated innate immune sensing and metabolism in myeloid cells (2019) (3)
- MEDB-62. Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation (2022) (3)
- HIV-1 infection – induced apoptotic microparticles inhibit human DCs via CD 44 (2012) (3)
- OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo (2015) (3)
- ATM and Chk 2 kinase target the p 53 cofactor Strap (2008) (3)
- Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells. (2017) (3)
- Supplemental Information Metalloprotease SPRTN / DVC 1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair (2016) (3)
- TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts (2020) (3)
- Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells (2019) (3)
- A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation (2020) (3)
- An exposition of ejaculate senescence and its inhibition in Drosophila (2019) (3)
- Correction: The deubiquitylase USP9X controls ribosomal stalling (2021) (3)
- Correction: Protein Profiling in Hepatocellular Carcinoma by Label-Free Quantitative Proteomics in Two West African Populations (2013) (3)
- SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses (2022) (2)
- Protein arginine methylation: a prominent modification and its demethylation (2017) (2)
- Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability (2020) (2)
- Improved profiling of polyamines using two-dimensional gas chromatography mass spectrometry. (2019) (2)
- Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes (2008) (2)
- The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function (2020) (2)
- Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation. (2019) (2)
- Network Analysis of the CSF Proteome Characterizes Convergent Pathways of Cellular Dysfunction in ALS (2021) (2)
- Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions (2020) (2)
- Late Breaking Abstract - Prognostic and therapeutic markers of malignant pleural effusion – The PROMISE study (2017) (2)
- Deceased donor kidney degradomics indicate cytoskeletal proteolytic alterations impact post-transplant function. (2021) (2)
- Mitochondrial proteome analysis reveals changes in expression of multiple proteins in pancreatic beta cells exposed to high glucose (2010) (2)
- A proteomic approach to the identification of marker proteins for ankylosing spondylitis and rheumatoid arthritis (2005) (2)
- Comparative Quantitative Proteomic Profiling of Urine from Stone-Forming and Non-Stone Forming Patients to Identify Candidate Regulators of Urolithiasis (2010) (2)
- The proteome of young and healthy human hamstring (2012) (1)
- Production Perforin-Dependent Cytotoxicity or Cytokine Activate CTL for Fas-But Not Resulting in Weak TCR Signaling (1998) (1)
- Protein interactions involving LARP1 in chemotherapy resistant ovarian cancer cells (2017) (1)
- Tight metabolic coupling of the proteasome with downstream oligopeptidases. (1999) (1)
- Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank. (2016) (1)
- Alternative Angiogenesis Mechanisms in Uterine Fibroids Related to Heavy Menstrual Bleeding. (2019) (1)
- Capturing the dynamics of genome replication on individual ultra-long nanopore sequence reads (2019) (1)
- Diagnostic Cerebrospinal Fluid Biomarker Discovery and Validation in Patients with Central Nervous System Infections (2020) (1)
- Editorial: Probing the Ubiquitin Landscape (2020) (1)
- ABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA mass spectrometry methods (2022) (1)
- Correction: Immunodominance of cytotoxic T lymphocyte epitopes co‐injected in vivo and modulation by interleukin‐12, Vol 26 (11) 1996, 2709–2716 (2005) (1)
- Subclinical effects of remote ischaemic conditioning in human kidney transplants revealed by quantitative proteomics (2020) (1)
- Deep topographic proteomics of a human brain tumour (2023) (1)
- Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins (2022) (1)
- Doxycycline Alters the Porcine Renal Proteome and Degradome during Hypothermic Machine Perfusion (2022) (1)
- Spondylarthropathies (including psoriatic arthritis) 244. Validity of Colour Doppler and Spectral Doppler Ultrasound of Sacroilicac Joints Againts Physical Examination as Gold Standard (2011) (1)
- Integration of Proteomics and Metabolomics to Unravel the Mechanism of Ischemia Reperfusion Injury in Donor Kidneys for Transplantation.: Abstract# 694 (2014) (1)
- 53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ (2018) (1)
- ABPP-HT*—Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods (2022) (1)
- Plasma Biomarker Profile Alterations during Variable Blood Storage. (2016) (1)
- Author response: RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes (2016) (1)
- The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage (2018) (1)
- Author response: Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells (2019) (1)
- Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6 (2023) (1)
- sion through Cleavage of Protease Nexin-1 (2010) (1)
- Otubains (2012) (0)
- Back Cover: Immunopeptidomic Profiling of HLA-A2-Positive Triple Negative Breast Cancer Identifies Potential Immunotherapy Target Antigens (2018) (0)
- PARP and DNA-PK Recruit XRCC1 to Stalled Replication Forks to Mediate Repair (2016) (0)
- Probing the NLRP3 inflammasome for drug targets in inflammatory disease (2021) (0)
- Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC (2022) (0)
- E23 Urinary metabolomics: The future of stone diagnosis? (2013) (0)
- A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption (2017) (0)
- Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function (2012) (0)
- Author Correction: Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability (2021) (0)
- Author response: USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma (2021) (0)
- Exosome Proteins from Peritoneal Fluid Samples of Women as Potential Biomarkers of Endometriosis. (2019) (0)
- Integrated Plaque and Plasma Proteo-Lipidomics Reveal Novel Signatures of Coronary Atherosclerotic Plaque Disruption (2013) (0)
- Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases (2018) (0)
- Comparison of gel-aided sample preparation (GASP) and two in-solution digestion workflows for proteomic analysis using Saccharomyces cerevisiae lysate (2018) (0)
- E94 Label-Free quantitative proteomics reveals differentially regulated proteins influencing urolithiasis (2011) (0)
- Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model (2022) (0)
- Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics (2023) (0)
- E92 Human renal tubular cells differentially secrete proteins in response to calcium oxalate crystal exposure (2013) (0)
- PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000299a (2019) (0)
- Identification and validation of non-histone protein acetylation regulated by the DNA damage response (2019) (0)
- Colonic epithelial cell diversity in health and inflammatory bowel disease (2019) (0)
- Identification of the target self-antigens in ischemia/reperfusion injury (2005) (0)
- Age-Modulated Immuno-Metabolic Proteome Profiles of Deceased Donor Kidneys Predict 12-Month Posttransplant Outcome (2023) (0)
- Abstract B44: Protein interactions involving LARP1 in chemotherapy resistant ovarian cancer cells (2017) (0)
- A prostate carcinoma antigen reveals a new cytosolic class I processing pathway for endoplasmic reticulum targeted proteins (2007) (0)
- Advancing mechanistic understanding and biomarker development in amyotrophic lateral sclerosis (2021) (0)
- ACTIVATION OF CYTOPROTECTION MECHANISMS IN DBD DONOR KIDNEYS DEFINE KIDNEY FUNCTION IN TRANSPLANT RECIPIENTS- A STUDY USING CLINICAL SAMPLES OBTAINED FROM THE QUOD BIOBANK (2016) (0)
- PYK2 controls intestinal inflammation via activation of IRF5 in macrophages (2020) (0)
- Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection (2022) (0)
- Colonic Epithelial Cell Diversity in Health and IBD (2019) (0)
- Oxidative Stress in Endometriosis Induces IL-8 Release Directly via 4-HNE. (2018) (0)
- AB0191 ERAP1, HLA-B27 and antigen presentation in ankylosing spondylitis (2013) (0)
- 2143 QUANTITATIVE PROTEOMICS IDENTIFIES CERULOPLASMIN AS A POTENTIAL PROMOTER OF UROLITHIASIS (2011) (0)
- Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities (2021) (0)
- DNA Modification under Mild Conditions by Suzuki—Miyaura Cross‐Coupling for the Generation of Functional Probes. (2014) (0)
- POTENTIAL PROTECTIVE EFFECTS OF DOXYCYCLINE ON RENAL PROTEOME AND DEGRADOME DURING HYPOTHERMIC MACHINE PERFUSION AND REPERFUSION OF PORCINE KIDNEYS (2020) (0)
- The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function (2021) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000506a (2019) (0)
- Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions (2020) (0)
- 344.11: Unravelling the Molecular Footprint of Kidney Graft Quality: From Subjective Assessment to Tailored Treatment (2022) (0)
- Ankylosing spondylitis monocytes show upregulation of proteins involved in antigen presentation (2008) (0)
- Proteomics and metabolomics applications in cancer biology (2019) (0)
- Author response: KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands (2012) (0)
- Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism (2022) (0)
- Apoptotic microparticles generated during acute HIV-1 infection inhibit human dendritic cells via CD44 (2012) (0)
- P10-05. Suppression of human dendritic cell function during acute HIV infection (2009) (0)
- Apoptotic microparticles generated during acute HIV-1 infection inhibit human dendritic cells via CD44 (2012) (0)
- NOD2 signalling in Crohn's disease (2011) (0)
- S94 Biological markers of favourable prognosis and successful pleurodesis for malignant pleural effusion (2016) (0)
- Activity-Based Protein Profiling (ABPP) for Cellular Deubiquitinase (DUB) and Inhibitor Profiling at Deep and High-Throughput Levels. (2023) (0)
- Chapter 477 Otubains (2013) (0)
- The efficiency of antigen recognition by CTL is determined by the frequency of serial TCR engagement (1998) (0)
- β-TrCP and Casein Kinase IIα Mediated Degradation of Cyclin F Controls Timely Mitotic Entry (2018) (0)
- Nilabh Shastri - Towards understanding classical and non-classical MHC-I antigen processing and presentation. (2022) (0)
- Abstract LB-080: USP18 modulates the ISGylome, immune signaling and sensitizes tumor cells to irradiation and CTL recognition (2020) (0)
- Abstract SY20-01: USP18 modulates the ISGylome immune signaling, and sensitizes tumor cells to irradiation and CTL recognition (2020) (0)
- Deletion of the deISGylating enzyme USP 18 enhances 1 tumour cell antigenicity and radiosensitivity 2 3 (2020) (0)
- INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 (ERAP1) IN ANKYLOSING SPONDYLITIS (2010) (0)
- Erratum: T cell recognition of hapten. Anatomy of T cell receptor binding of a H-2K(d)-associated photoreactive peptide derivative (Journal of Biological Chemistry (1999) 274 (3622-3631) (1999) (0)
- Serial TCR Engagement CTL Clones Is Determined by the Frequency of + The Efficiency of Antigen Recognition by CD8 (1998) (0)
- INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 IN ANKYLOSING SPONDYLITIS (2012) (0)
- PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000597a (2019) (0)
- Aberrant recognition of epitope variants by CTL is controlled by CD8 (1997) (0)
- The role of mannose-binding lectin in natural IgM mediated ischemia/reperfusion injury (2005) (0)
- A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes (2018) (0)
- Protein metabolism in whole body and skeletal muscle of laboratory rats treated by proteasome inhibitors (2005) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000347a (2019) (0)
- Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations (2021) (0)
- Presence of Amine Oxidase 3 and its Role in Peritoneal Endometriosis Lesions. (2019) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000475a (2019) (0)
- Regulation of the endosomal SNX27-retromer by OTULIN (2019) (0)
- Plasma degradome affected by variable storage of human blood (2016) (0)
- Proteomic identification of host and parasite biomarkers in saliva from patients with uncomplicated Plasmodium falciparum malaria (2012) (0)
- Targeted delivery of galunisertib attenuates fibrogenesis in an integrated ex vivo renal transplant and fibrosis model (2022) (0)
- Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model (2021) (0)
- Investigating the redox-effector functions of BH4: Insights from in vitro studies of NO-redox balance (2014) (0)
- In Memoriam: Professor Huib Ovaa (1973-2020): A Uniquely Brilliant and Enthusiastic Scientist, a Pioneer in Chemical Biology and the Ubiquitin Field (2020) (0)
- Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death. (2016) (0)
- Crystal Structure of Human Otubain2 and Ubiquitin Complex (2013) (0)
- Abstract 1247: Comprehensive molecular profiling to predict first-line immunochemotherapy outcomes in inoperable esophageal adenocarcinoma (2022) (0)
- Cancer esearch or and Stem Cell Biology rix Metalloproteinase-9 Regulates Tumor Cell R sion through Cleavage of Protease Nexin-1 (2010) (0)
- M1676 Molecular Mechanism of NOD2 Mediated Autophagy Induction (2010) (0)
- Proteomics Reveals Molecular Window and Metabolism of Normothermically Perfused Human Kidneys. (2019) (0)
- O-027 Small extracellular vesicle (sEV) protein cargo as potential biomarker for endometriosis (2022) (0)
- Selective Binding of AIRAP L Tandem UIMs to Lys 48-Linked Tri-Ubiquitin Chains Graphical (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000110a (2019) (0)
- The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators (2022) (0)
- Discovering multiple potential targets for insulin sensitization in human adipose tissue using proteomic approaches (2007) (0)
- Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion (2018) (0)
- CSF extracellular vesicle proteomics demonstrates altered protein homeostasis in amyotrophic lateral sclerosis (2020) (0)
- Proteomics Pathways of Sickle Cell Anemia (P2SCA): A Comprehensive Analysis By Liquid Chromatography Mass Spectrometry of Erythrocyte Membrane Proteins Characterized from the Muhimbili Sickle Cell Programme, Tanzania (2018) (0)
- Tetrahydrobiopterin modulates ubiquitin conjugation to UBC 13 / UBE 2 N and proteasome activity by (2019) (0)
- USP18 is an essential regulator of muscle cell differentiation and maturation (2023) (0)
- Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. (2015) (0)
- Interplay between methylation and Cdk phosphorylation in growth control by retinoblastoma protein (2010) (0)
- Discrimination between HLA class I-bound and co-purified HIV-derived peptides in immunopeptidomics workflows (2018) (0)
- Dengue Virus stimulation of dendritic cells induces phosphorylation- and proteolysis-dependent signalling (2018) (0)
- Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation (2018) (0)
- Using “Omics” as a Novel Tool to Identify Mitochondrial Dysfunction and Metabolic Dysregulation as Critical Factors in Brain Death Induced Kidney Injury.: Abstract# 1475 (2014) (0)
- P02-16 The SOCS2 Ubiquitin ligase complex regulates Growth Hormone Receptor levels (2012) (0)
- Bromodomains control amyloid-like aggregation of aberrantly acetylated proteins. (2017) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000278a (2019) (0)
- E185 Urinary proteomics: What can we learn from cat urine? (2013) (0)
- PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000605a (2019) (0)
- Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation (2022) (0)
- Antigen Spondylitis monocytes show upregulation of proteins involved in antigen presentation (2008) (0)
- PROFIBROTIC TGF-B IN DECEASED DONOR KIDNEYS REGULATES CATABOLIC PATHWAYS AND LONG-TERM FUNCTION AFTER TRANSPLANTATION (2019) (0)
- P063 Investigation of the function of NOD2 in Crohn's disease using phosphoproteomics (2012) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000474a (2019) (0)
- Validation of Tau Antibodies for Use in Western Blotting and Immunohistochemistry (2023) (0)
- Reduced PABPN1 levels causes cytoskeleton disorganization and aberrant differentiation (2020) (0)
- Probing the Ubiquitin Landscape (2020) (0)
- PROTEOMIC PROFILES OF DECEASED DONOR KIDNEY BIOPSIES OBTAINED PRIOR TO TRANSPLANTATION CORRELATE WITH ALLOGRAFT FUNCTION AT ONE YEAR (2017) (0)
- b-TrCP-and Casein Kinas e II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression Graphical (2018) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000462a (2019) (0)
- Interactions between anatomy, vasculature, and extracellular matrix proteins in HLA-DRB1*15-mediated multiple sclerosis pathology (2019) (0)
- PROTEOMIC CHANGES IN LIVING KIDNEY DONORS IN RESPONSE TO LAPAROSCOPIC DONOR NEPHRECTOMY AND PROPOFOL OR SEVOFLURANE ANAESTHESIA (2017) (0)
- Sex-specific deubiquitylation drives immune-related neurodegeneration in Drosophila (2022) (0)
- A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes (2018) (0)
- Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation (2019) (0)
- METABOLIC DYSREGULATION AND MITOCHONDRIAL DYSFUNCTION DEFINE INJURY PROFILES OF DONOR KIDNEYS AFTER BRAIN DEATH AND ISCHAEMIA-REPERFUSION (2017) (0)
- ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 (ERAP1) PLAYS A CRITICAL ROLE IN PEPTIDE BINDING AND ANTIGEN PRESENTATION BY HLA-B27 (2012) (0)
- Ubiquitinome analysis of articular cartilage post mechanical injury reveals a differential ubiquitination pattern of a subset of DUBs and proteins linked to the ERAD cellular response (2022) (0)
- Discovery and Validation of Biomarkers to Guide Clinical Management of Pneumonia in (2014) (0)
- Biological markers of successful pleurodesis for malignant pleural effusion (2016) (0)
- W1808 Investigation of NOD2 Inflammasome Cross-Talk (2010) (0)
- PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000466a (2019) (0)
- MDC 1 Interacts with TOPB P 1 to Maintain Chromosomal Stability during Mitosis Graphical (2019) (0)
- OTUB2 has a broader cleavage profile than OTUB1. (2015) (0)
- Detection of BK virus in urine from renal transplant subjects by mass spectrometry (2012) (0)
- The deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1. (2021) (0)
- Mitochondrial Dysfunction Is a Common Feature of Injury in Donor Kidneys After Brain and Circulatory Death (2017) (0)
- USING PROTEOMICS AND METABOLOMICS AS NOVEL TOOLS TO IDENTIFY MITOCHONDRIAL DYSFUNCTION AND METABOLIC DYSREGULATION AS CRITICAL FACTORS IN BRAIN DEATH INDUCED KIDNEY INJURY (2014) (0)
- Asymmetric complex between HslV and I-domain deleted HslU (H. influenzae) (2003) (0)
- INTEGRATED OMICS APPROACH REVEALS NOVEL IL-23 TARGETS IN TH17 CELLS (2016) (0)
- DUB esterase activity further decodes ubiquitin’s enigma (2021) (0)
- DEBRIDEMENT AND IMPLANT RETENTION IN 39 CASES OF PERIPROSTHETIC HIP JOINT INFECTION: THE RELEVANCE OF CHANGING MOBILE PARTS (2015) (0)
- S18 Mechanism of NOD2 mediated autophagy (2010) (0)
- Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix (2018) (0)
- MASS SPECTROMETRY-BASED DETECTION AND QUANTITATION OF PUTATIVE BIOMARKERS FOR ANKYLOSING SPONDYLITIS (2011) (0)
- The interactome of human TDP-43 in a cellular model of amyotrophic lateral sclerosis (2019) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000352a (2019) (0)
- Crystal structure of USP7 in complex with the non-covalent inhibitor, FT671 (2017) (0)
- Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides (2022) (0)
- Comprar Activity-based Chemical Proteomics | Kessler, Benedikt M. | 9781603273114 | Springer (2009) (0)
- Injury IgM in a Model of Ischemia / Reperfusion Activation of the Lectin Pathway by Natural and (2006) (0)
- LARP1 regulates metabolism and mTORC1 activity in cancer (2022) (0)
- FBXL19 recruits CDK-Mediator to the CpG islands of developmental genes to prime them for activation during lineage commitment (2018) (0)
- Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions (2020) (0)
- Identification of novel NOD2-regulated proteins using phosphoproteomics (2012) (0)
- Exosomes as biomarkers in endometriosis (2018) (0)
- PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000065a (2019) (0)
- Matrix Metalloproteinase 9 Regulates Tumor Cell Invasion via Cleavage of Protease Nexin-1 (2012) (0)
- Characterising the Serum Proteome of Organ Donors to Identify Specific Molecular Signatures Associated With Function After Kidney Transplantation. (2014) (0)
- Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells (2020) (0)
- Survival of eggshell peptides over millions of years in Africa is due to mineral binding (2016) (0)
- From herbal small RNAs to one medicine (2019) (0)
- HslUV (H. influenzae)-NLVS Vinyl Sulfone Inhibitor Complex (2002) (0)
- Ischemia/Reperfusion Injury Natural IgM in a Model of Activation of the Lectin Pathway by (2010) (0)
- Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation (2015) (0)
- Discovery of Novel Molecular Mechanisms Underlying the Pathophysiology of Uterine Fibroids and Associated Heavy Menstrual Bleeding. (2020) (0)
- A Ubiquitin-specific Protease Involved in Regulation of Transcription (2013) (0)
- Biochemical characterization of a novel deubiquitinating enzyme otubain 1 and investigation into its role in Yersinia infection (2010) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000242a (2019) (0)
- deletion and small molecule inhibition destabilises c-MYC and elicits 1 regression of squamous cell lung carcinoma 2 3 (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000633a (2019) (0)
- Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo (2015) (0)
- Proteomic profiling of the plasma of Gambian children with cerebral malaria (2018) (0)
- Survival And Pleurodesis Response Markers In Malignant Pleural Effusion-The Promise Study (2018) (0)
- deletion and small molecule inhibition destabilises c-MYC and elicits 1 regression of squamous cell lung carcinoma 2 3 (0)
- Human USP18 protects diverse cancer lineages from Type I Interferon independently of its canonical catalytic function (2023) (0)
- Post-translational mutagenesis: a chemical synthetic strategy for exploration of protein side-chain diversity (2016) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000385a (2019) (0)
- Dendritic cells efficiently internalize and process exogenous peptides despite proteasome inhibition. (2002) (0)
- PanDDA analysis group deposition -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMOPL000711a (2019) (0)
- USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7 (2019) (0)
- Proteomic and Transcriptomic Analysis of Oxidative Stress, Lipid Peroxidation and Iron Uptake Signatures in Endometriotic Lesions. (2018) (0)
- PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human PARP14 Macrodomain 3 in complex with FMSOA000341b (2019) (0)
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