Benjamin Cravatt III

Benjamin Cravatt III's AcademicInfluence.com Rankings

Chemistry

#672

World Rank

#1141

Historical Rank

#297

USA Rank

Organic Chemistry

#110

World Rank

#146

Historical Rank

#43

USA Rank

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Chemistry

Why Is Benjamin Cravatt III Influential?

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According to Wikipedia, Benjamin Franklin Cravatt III is a professor in the Department of Chemistry at The Scripps Research Institute in La Jolla, California. Considered a co-inventor of activity-based proteomics and a substantial contributor to research on the endocannabinoid system, he is a prominent figure in the nascent field of chemical biology. Cravatt was elected to the National Academy of Sciences in 2014, and the American Academy of Arts and Sciences in 2016. He is Gilula Chair of Chemical Biology, a Cope Scholar, and a Searle Scholar.

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Benjamin Cravatt III's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides (1996) (1991)
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase (2001) (1243)
Quantitative reactivity profiling predicts functional cysteines in proteomes (2010) (1196)
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol (2007) (1027)
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines (2007) (1008)
Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. (2008) (982)
Activity-based protein profiling: the serine hydrolases. (1999) (906)
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects (2008) (836)
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis (2010) (823)
Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. (2003) (804)
Profiling enzyme activities in vivo using click chemistry methods. (2004) (674)
The biological impact of mass-spectrometry-based proteomics (2007) (652)
The promise and peril of chemical probes. (2015) (623)
Structure and function of fatty acid amide hydrolase. (2005) (612)
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation (2011) (583)
Chemical characterization of a family of brain lipids that induce sleep. (1995) (569)
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system (2010) (545)
Identification of protein pheromones that promote aggressive behaviour (2007) (481)
Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling (2002) (472)
Proteome-wide covalent ligand discovery in native biological systems (2016) (471)
The endogenous cannabinoid system protects against colonic inflammation. (2004) (467)
How many human proteoforms are there? (2018) (440)
Mechanism-based profiling of enzyme families. (2006) (434)
Molecular characterization of human and mouse fatty acid amide hydrolases. (1997) (430)
Segregation of two endocannabinoid‐hydrolyzing enzymes into pre‐ and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala (2004) (428)
Large-scale profiling of protein palmitoylation in mammalian cells (2009) (422)
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. (2009) (417)
Activity-based probes for the proteomic profiling of metalloproteases. (2004) (417)
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors (2010) (411)
Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System* (2005) (405)
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. (2008) (388)
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo (2009) (363)
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. (2006) (347)
Global Mapping of the Topography and Magnitude of Proteolytic Events in Apoptosis (2008) (345)
Profiling serine hydrolase activities in complex proteomes. (2001) (344)
A Second Fatty Acid Amide Hydrolase with Variable Distribution among Placental Mammals* (2006) (339)
Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity (2004) (332)
Comparative analysis of fatty acid amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling (2003) (328)
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes (2003) (323)
A new perspective on cannabinoid signalling: complimentary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. (1998) (318)
Assignment of endogenous substrates to enzymes by global metabolite profiling. (2004) (317)
A missense mutation in human fatty acid amide hydrolase associated with problem drug use (2002) (316)
Proteome-wide Mapping of Cholesterol-Interacting Proteins in Mammalian Cells (2013) (313)
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness (2002) (313)
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. (2010) (309)
Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain (2009) (309)
The endocannabinoid system drives neural progenitor proliferation (2005) (305)
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum (2008) (300)
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink (2013) (299)
Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system. (2003) (298)
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia (2004) (298)
The metabolic serine hydrolases and their functions in mammalian physiology and disease. (2011) (289)
Activity-based protein profiling for biochemical pathway discovery in cancer (2010) (285)
An Ion Channel Essential for Sensing Chemical Damage (2007) (282)
Global profiling of dynamic protein palmitoylation (2011) (281)
Chemical Probes of Endocannabinoid Metabolism (2013) (281)
Endocannabinoid Biosynthesis Proceeding through Glycerophospho-N-acyl Ethanolamine and a Role for α/β-Hydrolase 4 in This Pathway* (2006) (272)
A roadmap to evaluate the proteome-wide selectivity of covalent kinase inhibitors (2014) (271)
Ligand and Target Discovery by Fragment-Based Screening in Human Cells (2017) (266)
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. (2009) (265)
Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System (2007) (264)
Circuitry for Associative Plasticity in the Amygdala Involves Endocannabinoid Signaling (2004) (257)
Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. (2000) (249)
Activity-based Proteomics of Enzyme Superfamilies: Serine Hydrolases as a Case Study* (2010) (249)
Enzyme inhibitor discovery by activity-based protein profiling. (2014) (247)
Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. (2004) (245)
Global profiling of lysine reactivity and ligandability in the human proteome. (2017) (242)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 (2017) (237)
Activity-based probes for proteomic profiling of histone deacetylase complexes (2007) (236)
The Sleep-inducing Lipid Oleamide Deconvolutes Gap Junction Communication and Calcium Wave Transmission in Glial Cells (1997) (236)
The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells (2006) (233)
Food Intake Regulates Oleoylethanolamide Formation and Degradation in the Proximal Small Intestine* (2007) (230)
The pharmacological landscape and therapeutic potential of serine hydrolases (2012) (229)
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. (2002) (228)
Chemical Strategies for Activity‐Based Proteomics (2004) (228)
Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. (2011) (227)
Lipopolysaccharide Induces Anandamide Synthesis in Macrophages via CD14/MAPK/Phosphoinositide 3-Kinase/NF-κB Independently of Platelet-activating Factor* (2003) (226)
A streamlined platform for high-content functional proteomics of primary human specimens (2005) (225)
Functional disassociation of the central and peripheral fatty acid amide signaling systems. (2004) (221)
Proteomic profiling of metalloprotease activities with cocktails of active-site probes (2006) (220)
The Expanding Role of Mass Spectrometry in Metabolite Profiling and Characterization (2005) (217)
Activity-based protein profiling for the functional annotation of enzymes (2007) (216)
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling (2005) (215)
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)—a general method for mapping sites of probe modification in proteomes (2007) (214)
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening (2010) (211)
Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. (2005) (209)
Disparate proteome reactivity profiles of carbon electrophiles. (2008) (209)
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles (2013) (209)
FAAH genetic variation enhances fronto-amygdala function in mouse and human (2015) (208)
The endogenous cannabinoid system and its role in nociceptive behavior. (2004) (208)
Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors (2011) (206)
Anandamide Biosynthesis Catalyzed by the Phosphodiesterase GDE1 and Detection of Glycerophospho-N-acyl Ethanolamine Precursors in Mouse Brain* (2008) (206)
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16 (2018) (204)
Determining target engagement in living systems. (2013) (203)
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. (2005) (203)
Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain (2011) (202)
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype (2002) (200)
Protein-reactive natural products. (2005) (198)
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. (2007) (197)
The development and application of methods for activity-based protein profiling. (2004) (194)
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. (2006) (194)
DAGLβ Inhibition Perturbs a Lipid Network Involved in Macrophage Inflammatory Responses (2012) (191)
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. (2016) (190)
Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase (2003) (186)
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes (2009) (185)
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. (2004) (183)
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality (2007) (182)
Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure (2013) (181)
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. (2006) (178)
Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations. (2000) (177)
Inhibition of Fatty-Acid Amide Hydrolase Accelerates Acquisition and Extinction Rates in a Spatial Memory Task (2007) (171)
A tandem orthogonal proteolysis strategy for high-content chemical proteomics. (2005) (171)
Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. (2011) (170)
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay (2011) (170)
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. (2012) (167)
A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells (2015) (165)
Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite (2013) (162)
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases (2017) (162)
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine (2016) (160)
Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling (2009) (160)
Chemical Strategies for Functional Proteomics* (2002) (158)
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer (2017) (156)
Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system (1997) (156)
Synergistic Interactions between Cannabinoids and Environmental Stress in the Activation of the Central Amygdala (2005) (155)
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. (2007) (154)
Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders (2009) (150)
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC (2013) (149)
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue. (2016) (148)
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization. (1998) (147)
Repeated Low-Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains Cannabinoid Receptor Type 1–Mediated Antinociceptive and Gastroprotective Effects (2013) (146)
Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties. (1999) (145)
"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. (2018) (142)
A Second Mammalian N-Myristoyltransferase* (1998) (138)
Assignment of protein function in the postgenomic era (2005) (137)
Chemical strategies for the global analysis of protein function. (2000) (137)
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. (2008) (136)
Profiling the specific reactivity of the proteome with non-directed activity-based probes. (2001) (136)
Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo. (2010) (135)
Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice (2011) (134)
Fatty acid amide hydrolase deficiency limits early pregnancy events. (2006) (133)
Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells (2016) (133)
Structure-guided inhibitor design for human FAAH by interspecies active site conversion (2008) (131)
DHHC5 Protein Palmitoylates Flotillin-2 and Is Rapidly Degraded on Induction of Neuronal Differentiation in Cultured Cells* (2011) (130)
Functional Interplay between Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome (2012) (129)
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism. (1999) (129)
How chemoproteomics can enable drug discovery and development. (2012) (128)
Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry Published, JLR Papers in Press, January 16, 2004. DOI 10.1194/jlr.M300475-JLR200 (2004) (128)
Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells (2008) (126)
Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei (2008) (125)
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. (2000) (125)
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium (2019) (125)
Clarifying the Catalytic Roles of Conserved Residues in the Amidase Signature Family* (2000) (124)
Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. (1998) (124)
The enzymatic inactivation of the fatty acid amide class of signaling lipids. (2002) (123)
Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes. (2008) (123)
Evidence for Distinct Roles in Catalysis for Residues of the Serine-Serine-Lysine Catalytic Triad of Fatty Acid Amide Hydrolase* (2003) (122)
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. (2006) (122)
Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. (1998) (121)
Role of Endocannabinoids in Alcohol Consumption and Intoxication: Studies of Mice Lacking Fatty Acid Amide Hydrolase (2007) (120)
Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms. (2010) (119)
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition (2015) (118)
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes (2015) (118)
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity Published, JLR Papers in Press, December 1, 2004. DOI 10.1194/jlr.M400377-JLR200 (2005) (118)
Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. (2013) (117)
The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase (2014) (116)
Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. (2013) (114)
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. (2012) (114)
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways (2009) (113)
Biomarkers of Endocannabinoid System Activation in Severe Obesity (2010) (112)
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay (2014) (111)
Activation of the endocannabinoid system by organophosphorus nerve agents. (2008) (111)
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. (2013) (111)
Cocaine- and Amphetamine-Related Transcript Is Involved in the Orexigenic Effect of Endogenous Anandamide (2005) (111)
Localization of N‐acyl phosphatidylethanolamine phospholipase D (NAPE‐PLD) expression in mouse brain: A new perspective on N‐acylethanolamines as neural signaling molecules (2008) (111)
Synergy between Enzyme Inhibitors of Fatty Acid Amide Hydrolase and Cyclooxygenase in Visceral Nociception (2009) (111)
Neural precursor cells induce cell death of high-grade astrocytomas via stimulation of TRPV1 (2012) (109)
Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling (2014) (107)
Regulation of Inflammatory Pain by Inhibition of Fatty Acid Amide Hydrolase (2010) (107)
Global profiling strategies for mapping dysregulated metabolic pathways in cancer. (2012) (107)
Inhibition of Oleamide Hydrolase Catalyzed Hydrolysis of the Endogenous Sleep-Inducing Lipid cis-9-Octadecenamide (1996) (107)
A small molecule accelerates neuronal differentiation in the adult rat (2010) (106)
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes (2013) (106)
Inhibitors of Endocannabinoid-Metabolizing Enzymes Reduce Precipitated Withdrawal Responses in THC-Dependent Mice (2009) (105)
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. (2013) (105)
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice (2006) (105)
Enzymatic Machinery for Endocannabinoid Biosynthesis Associated with Calcium Stores in Glutamatergic Axon Terminals (2008) (104)
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells (2020) (103)
Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. (1999) (103)
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. (2007) (102)
Blockade of Endocannabinoid Hydrolytic Enzymes Attenuates Precipitated Opioid Withdrawal Symptoms in Mice (2011) (102)
Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition. (2013) (101)
Fatty Acid Amide Hydrolase Determines Anandamide-induced Cell Death in the Liver* (2006) (100)
Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk (2007) (98)
Fatty acid amide hydrolase substrate specificity. (2000) (98)
ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. (2014) (97)
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. (2019) (96)
Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. (2008) (96)
Monoacylglycerol Lipase Limits the Duration of Endocannabinoid-Mediated Depolarization-Induced Suppression of Excitation in Autaptic Hippocampal Neurons (2009) (96)
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors (2011) (95)
The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice (2012) (95)
ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice (2014) (94)
Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake. (2004) (94)
Autosomal Ichthyosis with Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice* (2007) (94)
Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. (2007) (93)
A suite of activity-based probes for human cytochrome P450 enzymes. (2009) (93)
Transcriptional regulation of the mouse fatty acid amide hydrolase gene. (2002) (92)
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation. (2010) (92)
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions (2020) (92)
Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. (2013) (91)
Discovering disease-associated enzymes by proteome reactivity profiling. (2004) (91)
Mapping enzyme active sites in complex proteomes. (2004) (91)
Cerebrodiene: a brain lipid isolated from sleep-deprived cats. (1994) (90)
Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo. (2007) (90)
A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines (2016) (89)
Diversity of Serine Hydrolase Activities of Unchallenged and Botrytis-infected Arabidopsis thaliana*S (2009) (89)
Enzymatic Pathways that Regulate Endocannabinoid Signaling in the Nervous System (2008) (89)
Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice (2011) (88)
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. (2005) (88)
Fully functionalized small-molecule probes for integrated phenotypic screening and target identification. (2012) (87)
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. (2010) (87)
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver (2011) (87)
Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. (2007) (87)
Effect of Oleamide on Sleep and Its Relationship to Blood Pressure, Body Temperature, and Locomotor Activity in Rats (2001) (86)
Structure Determination of an Endogenous Sleep-Inducing Lipid, cis-9-Octadecenamide (Oleamide): A Synthetic Approach to the Chemical Analysis of Trace Quantities of a Natural Product (1996) (86)
Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. (2016) (86)
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. (2019) (85)
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase[S] (2011) (84)
The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain (2013) (83)
A fluopol-ABPP HTS assay to identify PAD inhibitors. (2010) (82)
Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. (2009) (82)
Global strategies to integrate the proteome and metabolome. (2005) (82)
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. (2005) (82)
Endocannabinoid Modulation of Scratching Response in an Acute Allergenic Model: A New Prospective Neural Therapeutic Target for Pruritus (2009) (81)
Activity‐Based Protein Profiling (ABPP) and Click Chemistry (CC)–ABPP by MudPIT Mass Spectrometry (2009) (80)
A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. (2011) (80)
N-Palmitoyl Glycine, a Novel Endogenous Lipid That Acts As a Modulator of Calcium Influx and Nitric Oxide Production in Sensory Neurons (2008) (80)
FAAH−/− Mice Display Differential Tolerance, Dependence, and Cannabinoid Receptor Adaptation After Δ9-Tetrahydrocannabinol and Anandamide Administration (2010) (80)
Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide Hydrolase Inhibition (2010) (80)
Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate (2013) (80)
Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries (2021) (80)
The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine. (2009) (79)
Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice (2011) (78)
Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs (2019) (77)
Fatty acid amide hydrolase is a key regulator of the endocannabinoid‐induced myocardial tissue injury (2011) (76)
Proteins regulating the biosynthesis and inactivation of neuromodulatory fatty acid amides. (2001) (74)
Trifunctional Chemical Probes for the Consolidated Detection and Identification of Enzyme Activities from Complex Proteomes*S (2002) (74)
Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. (2015) (74)
Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases. (2013) (73)
Retrograde endocannabinoid signaling in the cerebellar cortex (2008) (73)
Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. (2004) (72)
Blockade of 2‐arachidonoylglycerol hydrolysis produces antidepressant‐like effects and enhances adult hippocampal neurogenesis and synaptic plasticity (2015) (72)
Chemoselective probes for metabolite enrichment and profiling (2007) (71)
Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans. (2013) (70)
A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation (2016) (70)
Mapping the Protein Interaction Landscape for Fully Functionalized Small-Molecule Probes in Human Cells (2014) (69)
Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. (2011) (69)
Evaluation of fatty acid amides in the carrageenan-induced paw edema model (2008) (68)
PGRMC2 is an Intracellular Heme Chaperone Critical for Adipocyte Function (2019) (68)
Architecture of cannabinoid signaling in mouse retina (2010) (68)
PLD3 and PLD4 are single stranded acid exonucleases that regulate endosomal nucleic acid sensing (2018) (67)
Potent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase (2007) (67)
RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia (2009) (67)
Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). (2013) (67)
Selective Monoacylglycerol Lipase Inhibitors: Antinociceptive versus Cannabimimetic Effects in Mice (2015) (66)
Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis* (2011) (65)
Analytical platforms for activity-based protein profiling--exploiting the versatility of chemistry for functional proteomics. (2006) (65)
A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. (2017) (64)
Chemoproteomic profiling and discovery of protein electrophiles in human cells (2016) (64)
Microarray platform for profiling enzyme activities in complex proteomes. (2004) (64)
In Situ trans Ligands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics* (2010) (64)
Design of activated serine-containing catalytic triads with atomic level accuracy (2014) (64)
A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2‐arachidonoylglycerol with potential anti‐obesity effects (2013) (64)
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signaling (2014) (64)
Erratum: Corrigendum: Assignment of protein function in the postgenomic era (2005) (64)
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH). (2009) (63)
Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids (2011) (63)
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis (2011) (62)
Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome (2013) (62)
Global Profiling of Proteolysis during Rupture of Plasmodium falciparum from the Host Erythrocyte* (2010) (62)
Dual Inhibition of Endocannabinoid Catabolic Enzymes Produces Enhanced Antiwithdrawal Effects in Morphine-Dependent Mice (2013) (62)
Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. (2012) (62)
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion (2011) (62)
β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR‐α, PPAR‐γ and TRPV1, but not CB1 or CB2 receptors (2012) (62)
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors. (2017) (62)
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. (2001) (61)
Mechanism‐Based Profiling of Enzyme Families (2006) (61)
Structure−Activity Relationships of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase (2007) (61)
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. (2011) (60)
Chemical Proteomic Profiling of Human Methyltransferases. (2016) (59)
Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury (2009) (59)
Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice. (2012) (59)
Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization. (2012) (58)
Activity-based probes that target functional subclasses of phospholipases in proteomes. (2010) (57)
Cell Surface Proteomics Identifies Molecules Functionally Linked to Tumor Cell Intravasation* (2008) (57)
The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice (2017) (57)
An in vivo multiplexed small-molecule screening platform (2016) (56)
Genetic deletion of monoacylglycerol lipase alters endocannabinoid‐mediated retrograde synaptic depression in the cerebellum (2011) (55)
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2‐arachidonoyl glycerol attenuates nausea in rats (2012) (55)
An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase. (1998) (55)
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. (2010) (54)
Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. (2007) (53)
AIG1 and ADTRP are Atypical Integral Membrane Hydrolases that Degrade Bioactive FAHFAs (2016) (53)
A brain detoxifying enzyme for organophosphorus nerve poisons (2005) (52)
Genetic Loss of Faah Compromises Male Fertility in Mice1 (2009) (52)
Click Chemistry‐Led Advances in High Content Functional Proteomics (2007) (52)
O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. (2012) (52)
A proteome-wide atlas of lysine-reactive chemistry (2021) (51)
Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake (2018) (51)
Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. (2015) (51)
Targeted Disruption of the PME-1 Gene Causes Loss of Demethylated PP2A and Perinatal Lethality in Mice (2008) (50)
An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis. (2009) (50)
The RON‐receptor regulates pancreatic cancer cell migration through phosphorylation‐dependent breakdown of the hemidesmosome (2012) (50)
Food for thought: endocannabinoid modulation of lipogenesis. (2005) (50)
Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. (2016) (49)
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. (2010) (49)
Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. (2008) (49)
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis (2006) (49)
Cholesteryl ester hydrolase activity is abolished in HSL macrophages but unchanged in macrophages lacking KIAA1363[S] (2010) (49)
Activity-based Protein Profiling Implicates Urokinase Activation as a Key Step in Human Fibrosarcoma Intravasation* (2006) (49)
Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners. (2011) (48)
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras. (2021) (48)
Discovery metabolite profiling--forging functional connections between the proteome and metabolome. (2005) (48)
Metalloprotease Inhibitors GM6001 and TAPI-0 Inhibit the Obligate Intracellular Human Pathogen Chlamydia trachomatis by Targeting Peptide Deformylase of the Bacterium* (2006) (48)
Structural commonalities among integral membrane enzymes (2004) (48)
Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. (2013) (47)
Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. (2006) (47)
The Endogenous Lipid Oleamide Activates Serotonin 5‐HT7 Neurons in Mouse Thalamus and Hypothalamus (1999) (47)
Role of the satiety factor oleoylethanolamide in alcoholism (2016) (47)
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model (2016) (47)
Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA. (2003) (46)
Proteomics--advances, applications and the challenges that remain. (2002) (46)
Fatty Acid Amide Hydrolase Deficiency Enhances Intraplaque Neutrophil Recruitment in Atherosclerotic Mice (2013) (45)
Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. (2015) (45)
Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. (2011) (45)
Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy (2018) (45)
Genomics and proteomics: From genes to function: advances in applications of chemical and systems biology (2007) (44)
Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver (2018) (44)
(-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1. (2003) (44)
Fatty Acid Amide Hydrolase (–/–) Mice Exhibit an Increased Sensitivity to the Disruptive Effects of Anandamide or Oleamide in a Working Memory Water Maze Task (2006) (44)
Enrichment tags for enhanced-resolution profiling of the polar metabolome. (2007) (44)
ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. (2015) (44)
Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes. (2018) (43)
Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition. (2012) (43)
Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs (2017) (42)
Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models (2014) (42)
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients (2017) (41)
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides. (2007) (41)
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo (2018) (40)
Abstract 215: Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. (2013) (40)
Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex (2016) (39)
Endocannabinoid Overload (2010) (39)
2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles. (2020) (39)
Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors. (2007) (38)
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation (2017) (38)
IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration. (2011) (37)
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice (2020) (37)
Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions. (2006) (37)
An activity-based imaging probe for the integral membrane hydrolase KIAA1363. (2012) (37)
Two Novel Mutations in ABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects (2013) (36)
The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. (2010) (36)
Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex (2019) (36)
Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. (2015) (36)
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. (2008) (36)
Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms (2018) (35)
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. (2007) (34)
Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH. (2014) (34)
Comparative assessment of large-scale proteomic studies of apoptotic proteolysis. (2009) (34)
In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies. (2018) (34)
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator (2020) (34)
Covalent Modulators of the Vacuolar ATPase. (2017) (34)
Design, synthesis, and biological evaluation of a biyouyanagin compound library (2011) (33)
Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors. (2016) (33)
Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination (2018) (33)
Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone (2014) (33)
Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice (2015) (33)
Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474. (2019) (33)
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. (2015) (33)
Steady-State Hydrogen Peroxide Induces Glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa (2014) (33)
Endocannabinoid regulation of amyloid-induced neuroinflammation (2015) (32)
Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. (2011) (32)
Δ9-Tetrahydrocannabinol and Endocannabinoid Degradative Enzyme Inhibitors Attenuate Intracranial Self-Stimulation in Mice (2015) (32)
Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. (1998) (32)
Assessing Enzyme Activities Using Stable Isotope Labeling and Mass Spectrometry *S (2007) (32)
Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes. (2006) (32)
Prolonged Monoacylglycerol Lipase Blockade Causes Equivalent Cannabinoid Receptor Type 1 Receptor–Mediated Adaptations in Fatty Acid Amide Hydrolase Wild-Type and Knockout Mice (2014) (32)
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism (2012) (31)
Sex‐dependent effects of endocannabinoid modulation of conditioned fear extinction in rats (2020) (31)
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. (2006) (31)
Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling (2018) (31)
Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites. (2017) (31)
CROSSING EXTREME MECHANISTIC BARRIERS BY ANTIBODY CATALYSIS : SYN ELIMINATION TO A CIS OLEFIN (1994) (31)
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions (2013) (30)
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. (2017) (30)
Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. (2017) (30)
Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice. (2015) (30)
Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. (2013) (30)
Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies (2015) (29)
Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling. (2005) (29)
Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats (2016) (29)
Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1 (2012) (29)
Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling. (2013) (29)
Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure (2016) (29)
Introduction to Peptides and Proteins (2009) (29)
Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide (2000) (29)
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). (2013) (29)
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9). (2010) (29)
Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis (2014) (28)
The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH). (2012) (28)
Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation* (2013) (28)
Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. (2010) (28)
Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retianl pigment epithelial cells (2012) (28)
Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids. (2006) (28)
Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation (2015) (27)
Diced electrophoresis gel assay for screening enzymes with specified activities. (2013) (27)
Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus (2015) (27)
Global identification of caspase substrates using PROTOMAP (protein topography and migration analysis platform). (2014) (26)
Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. (2008) (26)
The proteome-wide potential for reversible covalency at cysteine. (2019) (26)
Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA). (2012) (26)
Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS (2018) (26)
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan (2019) (25)
Breast Cancer Cell Lines Grown In Vivo: What Goes in Isn’t Always the Same as What Comes Out (2005) (25)
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia (2020) (24)
Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases. (2015) (24)
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth (2021) (24)
Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP. (2012) (24)
Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug (2021) (24)
Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. (2017) (23)
Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12). (2019) (23)
Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family. (2008) (23)
Robust anti‐nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain (2016) (22)
Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. (2019) (22)
Identification of the Major Prostaglandin Glycerol Ester Hydrolase in Human Cancer Cells* (2014) (22)
Activity‐Based Probes for Monitoring Postproline Protease Activity (2009) (22)
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. (2011) (22)
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors (2017) (21)
Substrate-Free High-Throughput Screening Identifies Selective Inhibitors for Uncharacterized Enzymes (2009) (21)
Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model (2017) (21)
LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. (2010) (21)
Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture. (2016) (21)
Protein-Reactive Natural Products (2005) (21)
Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine. (2008) (20)
Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase (2014) (20)
Simultaneous Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Shares Discriminative Stimulus Effects with Δ9-Tetrahydrocannabinol in Mice (2015) (20)
Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ. (2018) (20)
Proteomics and genomics (2005) (20)
Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation (2013) (20)
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis (2019) (19)
AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice (2020) (19)
Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation. (2013) (19)
Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells. (2020) (19)
Anandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion. (2012) (19)
Discovery of small-molecule enzyme activators by activity-based protein profiling (2020) (19)
Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa† †Electronic supplementary information (ESI) available: Synthetic procedures and data, biological evaluations, chemical proteomics procedures and data. See DOI: 10.1039/c7sc04287f (2018) (19)
Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development. (2020) (19)
Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) (2014) (18)
Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats (2016) (18)
Activity-Based Labeling of Matrix Metalloproteinases in Living Vertebrate Embryos (2012) (17)
Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. (2009) (17)
The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase. (2018) (17)
Facile synthesis of borofragments and their evaluation in activity-based protein profiling. (2015) (17)
Cell-based ligand discovery for the ENL YEATS domain. (2020) (17)
Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis (2018) (17)
Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor. (2017) (16)
Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore (2016) (16)
Rapid Development of a Potent Photo‐triggered Inhibitor of the Serine Hydrolase RBBP9 (2012) (16)
Challenges for the 'chemical-systems' biologist. (2008) (16)
Practical 4'-phosphopantetheine active site discovery from proteomic samples. (2011) (15)
Evaluation of different drug classes on transient sciatic nerve injury–depressed marble burying in mice (2018) (15)
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis. (2022) (15)
Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) (2013) (14)
Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism[S] (2016) (14)
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. (2007) (14)
Endocannabinoid regulation of homeostatic feeding and stress‐induced alterations in food intake in male rats (2018) (14)
Closing the Gate to the Active Site (2006) (14)
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine (2022) (13)
Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization (2021) (13)
Global profiling of phosphorylation-dependent changes in cysteine reactivity (2022) (13)
Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. (2015) (13)
Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge (2015) (13)
Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum123 (2016) (13)
Rat and human fatty acid amide hydrolases: overt similarities and hidden differences. (2012) (13)
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. (2007) (13)
Design, Synthesis and Evaluation of 18F-labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. (2019) (13)
Inhibitory Control Deficits Associated with Upregulation of CB1R in the HIV-1 Tat Transgenic Mouse Model of Hand (2019) (13)
Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine‐induced dopamine release in the mouse nucleus accumbens (2018) (13)
Mechanistic and pharmacological characterization of PF-04457845 : a highly potent and selective FAAH inhibitor that reduces inflammatory and noninflammatory pain (2011) (12)
Monoacylglycerol Lipase Regulates Fever Response (2015) (12)
Ethanol‐induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice (2018) (12)
Kinase chemical genomics—a new rule for the exceptions (2005) (12)
In situ identification of cellular drug targets in mammalian tissue (2022) (12)
Application of activity-based protein profiling to study enzyme function in adipocytes. (2014) (12)
ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. (2020) (11)
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling (2021) (11)
Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase(). (2012) (11)
N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. (2019) (11)
Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase (2016) (11)
Lipid metabolism in cancer. (2013) (11)
Cannabinoid CB 1 receptors regulate neuronal TNF-a effects in experimental autoimmune encephalomyelitis (2011) (11)
Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. (2022) (11)
Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor (2013) (10)
Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (10)
Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice (2017) (10)
An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus (2015) (10)
Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe‐independent in Drosophila embryos (2010) (10)
The Scripps Molecular Screening Center and Translational Research Institute (2019) (10)
Inhibition of Protein Secretion in Escherichia coli and Sub-MIC Effects of Arylomycin Antibiotics (2018) (10)
ABHD4-dependent developmental anoikis safeguards the embryonic brain (2020) (9)
Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture (2020) (9)
The novel MAGL inhibitor MJN110 enhances responding to reward-predictive incentive cues by activation of CB1 receptors (2020) (9)
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. (2008) (9)
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. (2020) (9)
ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) (2014) (9)
Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain (2014) (9)
Diacylglycerol Lipase-Alpha Regulates Hippocampal-Dependent Learning and Memory Processes in Mice (2019) (9)
Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. (2017) (9)
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain (2022) (9)
Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat (2004) (9)
Role of interleukin 1‐beta in the inflammatory response in a fatty acid amide hydrolase‐knockout mouse model of Alzheimer’s disease (2018) (9)
CIMAGE2.0: An Expanded Tool for Quantitative Analysis of Activity-Based Protein Profiling (ABPP) Data. (2021) (8)
Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium‐sensitive N‐arachydonoylethanolamine‐synthesizing enzyme and related molecules in rat primary sensory neurons (2017) (8)
Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. (2016) (8)
Profiling of microRNA targets using activity-based protein profiling: linking enzyme activity to microRNA-185 function. (2021) (8)
A chemical proteomic probe for the mitochondrial pyruvate carrier complex. (2019) (7)
An abundant biliary fatty acid metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides. (2021) (7)
Challenges for the 'chemical-systems' (2008) (7)
PGRMC2 is an intracellular haem chaperone critical for adipocyte function (2019) (7)
Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6) (2013) (7)
Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones (2021) (7)
Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease (2021) (7)
Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold. (2021) (7)
Structural basis for a disfavored elimination reaction in catalytic antibody 1D4. (2001) (7)
GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration (2021) (7)
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. (2020) (7)
Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner (2019) (7)
The promise and peril of chemical probes (vol 11, pg 536, 2015) (2015) (6)
Activity-Based Protein Profiling (2019) (6)
Stereochemical Diversity as a Source of Discovery in Chemical Biology (2022) (6)
3-Oxo-β-Sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. (2020) (6)
Molecular medicine and neurodegenerative diseases. (2014) (6)
Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-β) (2013) (6)
Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211 (2013) (6)
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension (2022) (5)
Chemical Biology Meets Biological Chemistry Minireview Series* (2010) (5)
Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice (2016) (5)
Corrigendum: The promise and peril of chemical probes. (2015) (5)
Optimization and Characterization of an Inhibitor for Glutathione S-Tranferase Omega 1 (GSTO1) (2011) (5)
Synthesis of a functionalized rigid bicyclo[2.2.1]heptane : a useful hapten for eliciting catalytic antibodies (1994) (5)
Global profiling of proteolysis during rupture of P . falciparum from the host erythrocyte (2010) (5)
A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level. (2013) (5)
Inhibition of monoacylglycerol lipase reduces nicotine reward in the conditioned place preference test in male mice (2020) (5)
Discovery and Optimization of Piperidyl-1,2,3-Triazole Ureas as Potent, Selective, and In Vivo -Active Inhibitors of Alpha/Beta-Hydrolase Domain Containing 6 (ABHD6) (2014) (4)
Faculty Opinions recommendation of Modulation of anxiety through blockade of anandamide hydrolysis. (2003) (4)
An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides (2021) (4)
Erratum: The promise and peril of chemical probes (Nature Chemical Biology (2015) 11 (536-541)) (2015) (4)
Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments. (2018) (4)
Inhibition of monoacylglycerol lipase ( MAGL ) attenuates NSAID-induced gastric hemorrhages in mice (2011) (4)
Corrigendum: Click-generated triazole ureas as ultrapotent in vivo –active serine hydrolase inhibitors (2012) (4)
Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells (2021) (4)
Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping (2021) (4)
Chemical proteomic identification of functional cysteines with atypical electrophile reactivities. (2021) (4)
Editorial overview: Omics: Methods to monitor and manipulate biological systems: recent advances in 'omics'. (2015) (4)
Poster session 2 (2004) (4)
STRUCTURE AND FUNCTION OF FATTY ACID (2005) (4)
SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16. (2021) (4)
An activity-guided map of electrophile-cysteine interactions in primary human immune cells (2019) (4)
Global Mapping of the Topography and Magnitude of Proteolytic Events in Biological Systems (2008) (4)
Probe Report for PME-1 Inhibitors (2010) (3)
Targeting FAAH and COX to Treat Visceral Pain (2008) (3)
An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2) (2014) (3)
A masked zinger to block GPX4 (2020) (3)
Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus (2014) (3)
Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex (2021) (3)
Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity (2019) (3)
ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB1 Receptors. (2021) (3)
Ligands in crystal structures that aid in functional characterization (2010) (3)
Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat (2021) (3)
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids (2023) (3)
Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli. (2012) (2)
Proteomic Analysis Reveals IRAK4 As a Therapeutic Target in Chronic Lymphocytic Leukemia (2017) (2)
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides (2022) (2)
Glucagon and Thyroid Hormone: A Championship Team (2016) (2)
Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine (2022) (2)
activity of this receptor pathway by LDL receptor-related protein explains the antiinflammatory Regulation of tumor necrosis factor receptor-1 and the IKK-NF-{kappa}B (2009) (2)
Just add water: cannabinoid discrimination in a water T-maze with FAAH(−/−) and FAAH(+/+) mice (2016) (2)
ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth (2020) (2)
Proteomic discovery of chemical probes that perturb protein complexes in human cells (2022) (2)
A competitive activity-based protein profiling platform yields cell wall synthesis inhibitors active against replicating and non-replicating Mycobacterium tuberculosis (2021) (2)
Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1) (2011) (2)
Refinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity. (2021) (2)
Multiplexed proteomic profiling of cysteine reactivity and ligandability in human T cells (2021) (2)
Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) (2013) (2)
Diacylglycerol Lipase-β Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences. (2021) (2)
Identification of Enzyme Activities from Complex Proteomes (2002) (2)
D 9-Tetrahydrocannabinol and Endocannabinoid Degradative Enzyme Inhibitors Attenuate Intracranial Self-Stimulation in Mice s (2014) (2)
Single-cell profiling and SCOPE-seq reveal the lineage dynamics of adult neurogenesis and NOTUM as a key V-SVZ regulator (2019) (1)
N-Acylphosphatidylethanolamines as Novel Regulators of Gastrointestinal Motility in the Mouse (2011) (1)
Purification and Characterization of Proteins (2009) (1)
activity of this receptor related protein explains the antiinflammatory − pathway by LDL receptor B κ Regulation of tumor necrosis factor receptor-1 and the IKK (2008) (1)
105 Fatty acid amide hydrolase is a crucial determinant of anandamide-induced cell death in hepatic cell populations and mediates liver injury in vivo (2006) (1)
Chemistry Takes Center Stage for Identifying Cancer Targetability (2018) (1)
Themes Endocannabinoids and Liver Disease . III . Endocannabinoid effects on immune cells : implications for inflammatory liver diseases (2008) (1)
Nucleic Acid– Binding Proteins (2009) (1)
Short communication Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB 1 receptors (2007) (1)
Elevation of Endocannabinoids via Inhibition of their Catabolic Enzymes Attenuates the Precipitated Opioid Withdrawal Syndrome (2010) (1)
Probe Report for RBBP9 Inhibitors - Probe 2 (2010) (1)
Correction for Ogasawara et al., Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition (2016) (1)
Probe Development Efforts to Identify Novel Inhibitors of ABHD10 (2013) (1)
Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function (2021) (1)
Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms (2022) (1)
Assigning functionality to cysteines by base editing of cancer dependency genes (2022) (1)
alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain (2011) (1)
The identification of an enzyme that regulates ether lipid signaling pathways in cancer (2007) (1)
Blockade of 2-AG hydrolysis by selective monoacylglycerol lipase inhibitor JZL184 enhances retrograde endocannabinoid signaling (2009) (1)
TMEM164 is an acyltransferase that forms ferroptotic polyunsaturated ether phospholipids (2022) (1)
7. Chemical Strategies for Activity-based Proteomics (2008) (1)
The Endocannabinoid System: From Basic Research toTranslational Opportunity (2012) (1)
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions (2020) (1)
Broad‐range metalloprotease profiling in plants uncovers immunity provided by defence‐related metalloenzyme (2022) (1)
Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities (2022) (1)
Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH) (2014) (1)
Sequence Analysis and Function Prediction (2009) (1)
A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network (2022) (1)
Live chemical reports from the cell surface. (2005) (1)
Pharmacological inhibition of monoacylglycerol lipase enhances IGM plasma levels and limits atherogenesis in a CB2-dependent manner (2018) (1)
Table 2.2-1, Compounds submitted to the SMR collection (2013) (0)
Tetrahedron young investigator award 2008. (2008) (0)
Table A1.1, RBBP9 Inhibitors SAR Table (Oxime Ester Scaffold) (2010) (0)
Figure 2, IDE closed state, and open form of Pitrilysin (2014) (0)
Decision letter: Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) (0)
Figure 9, Benzoisothiazolones target a cysteine residue of IDE (2014) (0)
Abstract 36: Fatty Acid Amide Hydrolase Deficiency Is Associated with a Vulnerable Plaque Phenotype in Atherosclerotic Mice (2012) (0)
Table S3, Serine Hydrolase (SH) Abbreviations and Names (2014) (0)
Inhibiting endocannabinoid catabolic enzymes attenuates neuropathic pain via distinct cannabinoid receptor mediated mechanisms of action (2010) (0)
ΑΖΑ-β-LACTAM COMPOUNDS AND METHODS OF USING (2013) (0)
The metabolite α-ketobutyrate increases health and life spans by activating AMPK (2022) (0)
Chemokine-mediated angiogenesis : an essential link in the evolution of airway fibrosis ? (2005) (0)
Colonic Manometry Versus Colonic Scintigraphy as a Diagnostic Tool for Children With Severe Constipation (2011) (0)
[Table], Table of Assay Rationale and Description (2011) (0)
Table 3, SAR of R1 (2011) (0)
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing (2018) (0)
RESEARCH PAPER THEMED ISSUE (CANNABINOIDS IN BIOLOGY AND MEDICINE) (2011) (0)
Figure 3.6-5, Potency and selectivity of ML256 assessed by ABPP-MudPIT (2014) (0)
ABHD4-dependent developmental anoikis protects the prenatal brain from pathological insults (2019) (0)
Figure 3.6-1, Potency of ML256 (SID 125269079) and analogs against recombinant mouse pPAFAH in a complex proteome (293T Hek cell membranes overexpressing the enzyme) (2014) (0)
Proteomic and metabolomic analysis of inhibition of monoacylglycerol lipase (MAGL) in human prostate cancer. (2010) (0)
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors (2017) (0)
Figure 10, Structures (A) and competitive ABPP inhibition profiles (B) of ABHD11 inhibitors WWL222 (SID 124343013) and ML226. (2013) (0)
Abstract A25: In vivo evidence validating the palmitoylation/depalmitoylation cycle as a therapeutic target in NRAS mutant hematologic cancers (2020) (0)
Marble Burying: A Novel Measure of Murine Neuropathic Pain Depressed Behavior (2015) (0)
Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation. (2021) (0)
Biotinylated fluorophosphonate (FP-biotin) labelling of fibroblast activation protein alpha (FAPα) on chondrocyte membranes (2011) (0)
Synthesis of a Functionalized Rigid Bicyclo(2.2.1)heptane: A Useful Hapten for Eliciting Catalytic Antibodies. (1995) (0)
Figure 6, Cytotoxicity of probe ML226 and analog 34 in serum-free (A) and serum-supplemented (B) media (2013) (0)
Table S1, Compounds tested by Secondary Screening (AID 493105) (2013) (0)
Mapping Lipid Networks in Cancer by Integrated Proteomics and Metabolomics (2007) (0)
Anandamide biosynthesis catalyzed by the sequential actions of a phospholipase (ABH4) and phosphodiesterase (GDE1) on the precursor N‐acyl phosphatidylethanolamines (2008) (0)
Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation (2015) (0)
Biology of Reproduction Highlights (2009) (0)
Abstract PR16: A druggable transcriptional vulnerability in NRF2-dependent lung cancer (2017) (0)
Table A3.2, Initial round of SAR by purchase with large structural modifications (2010) (0)
Abstract TMEM-032: MULTIDISCIPLINARY CHARACTERIZATION OF OVARIAN CANCER SPHERES (2017) (0)
Author response: Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms (2018) (0)
(P2) Activity-Based Proteomics–Applications for Enzyme and Inhibitor Discovery (2013) (0)
Figure 2, Preparation of coupling partners A and B (2013) (0)
ANTIHYPERTENSIVE EFFECT OF THE NOVEL FAAH INHIBITOR AM3506 (2009) (0)
Activity‐Based Protein Profiling – Finding General Solutions to Specific Problems (2023) (0)
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. (2023) (0)
Table 4, Target SAR Analysis (2013) (0)
Chemoproteomic Discovery of AADACL1 as a Novel Regulator of Human Platelet Activation (2014) (0)
An Endogenous Sleep‐Inducing Compound is a Novel Competitive Inhibitor of Fatty Acid Amide Hydrolase. (1998) (0)
Faculty Opinions recommendation of ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. (2004) (0)
Table 5, Abbreviated SAR summary in the probe scaffold showing cell-free (biochemical) results (2014) (0)
Crystal structure of mouse nitrilase-2 at 1.4A resolution (2008) (0)
Figure 4, IC50s Curves for Probe ML211 (Compound 1.18, SID 99445338) as determined by gel-based competitive-ABPP with FP-Rh (AID 493110) against targets LYPLA1 and LYPLA2 (2013) (0)
The interface of chemical biology and the nervous system (related to the NIDA Chemical Genomics Symposium). (2010) (0)
Table S1, Activity of cherry-picked HTS hits against pPAFAH as assessed by gel-based competitive ABPP (AID 588474) (2014) (0)
Table 2, Most promising leads from HTS Campaign for PAFAH2 inhibitor discovery (2013) (0)
[Table], Table of Reagents and Source (2010) (0)
Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats (2015) (0)
Figure 9, Potency and selectivity of 34 assessed by SILAC-ABPP (2013) (0)
Table 1, IDE Inhibitor PubChem AIDs (click on hyperlink for details) (2014) (0)
Figure 2, N-Heterocyclic Urea SH Inhibitors (2013) (0)
Glutathione supports lipid abundance in vivo (2023) (0)
Table 2, Probe ML345 and Analogs (2014) (0)
Endocannabinoid dysfunction in neurological disease: neuro-ocular DAGLA-related syndrome (2022) (0)
ID: 335 Activity-based proteomics of proteases in human disease (2006) (0)
Table A3.1, Additional oxime ester SAR, including analogs of oxime ester 18 (CID 885318) (2010) (0)
Figure 1, IDE schematic structure (2014) (0)
Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease (2021) (0)
TRP channels-Convergent sites of action for phytochemicals and endogenous lipid transmitters that regulate human sensation and physiology. (2014) (0)
Table S2, SAR Analysis for Target: R2/R3 = cyclo (2011) (0)
found for each of these problems to enable the exten- sion of site-specific chemical labeling in vivo. Can you then imag(e)ine the possibilities? (2005) (0)
linking enabled proteomics (2010) (0)
Figure 10, Profile of most potent uHTS hit, CID 2325815 (2014) (0)
Figure 3.6-3, Selectivity of synthetic SAR compounds as assessed by gel-based competitive ABPP in the mouse brain membrane proteome (2014) (0)
Figure 2, Structures of prior art dual DAGL-α/β inhibitors THL and RHC80267 and DAGL-b inhibitor ML294 (2013) (0)
Introduction to Minireview Series : “ Chemical Biology Meets Biological Chemistry ” (2010) (0)
Primary amides of fatty acids for use in the sleeping introduction (1995) (0)
Remodeling oncogenic transcriptomes by small molecules targeting NONO. (2023) (0)
Figure A2.2, Cytotoxicity of RBBP9 inhibitors against HEK 293T cells after 48h of treatment as determined by the CellTiter-Glo assay (Promega) (2010) (0)
Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo (2017) (0)
Figure A2.1, Low throughput assays to characterize probe (2010) (0)
Figure 10, Cytotoxicity of probe and probe analogs in serum-free (A) and serum-supplemented (B) media (2011) (0)
Figure 9, Potency and selectivity of ML225 against anti-target pPAFAH (2013) (0)
Faculty Opinions recommendation of Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations. (2005) (0)
Endocannabinoid Degradation and Oxidative Defense Mechanisms Determine Anandamide-induced Cell Death in Liver Cell Populations (2006) (0)
Table 1, Comparative data on similar compound structures establishing SAR (2010) (0)
Figure 3.2-1, IC50 curves for probe ML256 (SID 125269079) as determined by gel-based competitive-ABPP with FP-Rh against purified, recombinant human pPAFAH (left) and overexpressed mouse pPAFAH in a complex proteome lysate (293T Hek membrane) (right) (2014) (0)
Science Signaling Podcast for 13 September 2016: DMF and the immune system (2016) (0)
Figure 7, In Situ inhibition of target enzymes (2013) (0)
Figure 7, Screening campaign overview (2014) (0)
Chemical strategies for the global analysis of protein function: Profiling hydrolytic enzymes in cancer (2001) (0)
35. Differential effects of endocannabinoid catabolic enzyme inhibition on thermal homeostasis following environmental or immunological stressors (2014) (0)
INHIBITEURS À TRIAZOLE DE DAGL(Α) (2017) (0)
Activity-based proteomics – protein and ligand discovery on a global scale (2019) (0)
Figure 4, Covalent modification of PAFAH2 by probe ML225 (Compound 29, SID 103913572) (2013) (0)
Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine (2022) (0)
Figure 4.1-1, Structure of darapladib, a GlaxoSmithKline drug in phase III clinical trials for the treatment of atherosclerosis (2014) (0)
Chemical Physiology 2008 (2009) (0)
Dual blockade of endocannabinoid hydrolyzing enzymes reveal a CB1 receptor-mediated interoceptive stimulus (2015) (0)
Nuclear Magnetic Resonance (NMR) (2009) (0)
Figure 3.5-3, Cytotoxicity anaysis of probe ML256 and analogs JMN4 and WWL153 in serum-free (A) and serum-supplemented (B) medium (AID 588768) (2014) (0)
Table 3.4-1, Target SAR Analysis (2014) (0)
Lysine metabolism conveys kidney protection in hypertension (2020) (0)
Figure 3.5-2, Inhibition of pPAFAH activity in vivo by probe ML256 (SID 125269079) (2014) (0)
Inhibition of both FAAH and MAGL, but not either separately, produces delta‐9‐THC like discriminative stimulus effects (2013) (0)
Table 3, Top HTS Hit from LYPLA1 Inhibitor Discovery Campaign (2013) (0)
Title Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet Permalink (2016) (0)
Figure 2, Flow chart describing HTS results (2013) (0)
Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750 (2008) (0)
Figure 9, In Situ inhibition of PME-1 activity (A) and PME-1-mediated PP2A demethylation (B) by probe compound 1 (SID 99206500) and compound 3 (SID 99206503) (2011) (0)
[Table], PMID List (2010) (0)
Activity-basedProteinProfilingImplicatesUrokinaseActivation asaKeyStepinHumanFibrosarcomaIntravasation * (2006) (0)
Time-controlled Transcardiac Perfusion Crosslinking (tcTPC): A Novel Tool for the In Vivo Study of Protein Interactions in Complex Tissues (2003) (0)
Isolation and Characterization of a Novel Phospholipase A1 Secreted from Human Platelets (2008) (0)
Figure 3, IC50 curve for probe ML225 (compound 29, SID 103913572) as determined by gel-based competitive-ABPP with FP-Rh (AID 504494) against target PAFAH2 in a complex proteome lysate (2013) (0)
Activity‐based proteomics ő applications for enzyme and inhibitor discovery (357.1) (2014) (0)
Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries (2021) (0)
Rapid Communication Fatty Acid Amide Hydrolase, the Degradative Enzyme for Anandamide and Oleamide, Has Selective Distribution in Neurons Within the Rat Central Nervous System (1997) (0)
Inhibition of Oleamide Hydrolase Catalyzed Hydrolysis of the Endogenous Sleep-Inducing Lipid cis-9-Octadecenamide. (1996) (0)
[Table, Probe Report for RBBP9 Inhibitors - Probe 2]. (2010) (0)
Amide hydrolase fatty acids. (1997) (0)
Figure 6, Selective inhibition of PAFAH2 activity in situ by probe ML225 (compound 29, band.) (2013) (0)
Protein–Ligand Interactions (2009) (0)
Figure 15, Prior art compounds (2014) (0)
Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge (2015) (0)
Figure 1, IC50 curves for probe ML294 (SID 125269120) and anti-probe ML295 (SID 125269138) (2013) (0)
Breast Cancer Cell Lines Grown in Vivo (2005) (0)
Running Title : Diacylglycerol lipase in inflammatory pain * (2017) (0)
Figure 3, IC50 curves for PADs 1–4 with ML325 (SID 118043677) as determined by biochemical substrate assay using the N-α-benzoyl-L-arginine ethyl ester HCl (BAEE) reagent (2013) (0)
Table 3.1-2, Representative carbamate SH inhibitors (2014) (0)
[Table], PME-1 Inhibitors SAR Table (2010) (0)
CALL FOR PAPERS Cardiovascular Aging Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase (2007) (0)
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole (2009) (0)
Faculty Opinions recommendation of Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies. (2003) (0)
Figure 3.6-2, Selectivity of HTS hit compounds as assessed by gel-based competitive ABPP with FP-Rh in the mouse brain membrane proteome (2014) (0)
From Chemistry to the Clinic: Pathways for Drug Discovery and Development. Part 2: Lead Generation, (2006) (0)
Chemical Biology ( )-FR 182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1 * * (2003) (0)
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium (2019) (0)
Figure 8, Probe development strategy, post-uHTS (2014) (0)
Table S6, SAR Analysis for Target: Aryl-Chlorides (2011) (0)
Table 4B, Target SAR Analysis for Compounds 21-34* (2013) (0)
Table 3, Hit summary, promiscuity analysis (reflects PubChem data available at time of uHTS) (2014) (0)
Figure 4, Cytotoxicity of Probe and Probe Analog in Serum-supplemented (A) and Serum-free (B) media (2011) (0)
Click Chemistry-Led Advances in High Content Functional Proteomics (2008) (0)
Correction for A small molecule accelerates neuronal differentiation in the adult rat, by Heiko Wurdak, Shoutian Zhu (2010) (0)
Figure 3, IC50 curve for probe ML226 (compound 12, SID 99445332) as determined by gel-based competitive-ABPP with FP-Rh (AID 504507) against target ABHD11 in a complex proteome lysate (2013) (0)
Table 3.4-2, Target SAR Analysis: Triazole Ureas* (2014) (0)
Genetic deletion of fatty acid amide hydrolase is associated with anti‐inflammatory cardiovascular phenotype in mice (2008) (0)
Figure 6, Synthesis of probe ML345 (2014) (0)
Figure 1, IC50 curves for probes ML295 (SID 125269138) and ML296 (SID 125269096) and compound 12 (SID 125269091) (2013) (0)
Faculty Opinions recommendation of Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. (2001) (0)
Figure 8, Potency and selectivity of additional triazole urea synthetic library compounds at three compound concentrations: 750 nM (A), 150 nM (B), and 30 nM (C) (2013) (0)
Figure 3.1-1, Flow chart describing HTS results (2013) (0)
Figure S3, Second Round Secondary Screening: Additional gel of competitive-ABPP profiling with select compounds for quantification of endogenous LYPLA1 (mouse brain membrane proteome) (2013) (0)
Author ' s personal copy Dual roles of brain serine hydrolase KIAA 1363 in ether lipid metabolism and organophosphate detoxification (2008) (0)
Figure 4, Covalent modification of ABHD11 by probe ML226 (compound 12, SID 99445332) (2013) (0)
ID: 303 Activity Based Protein Profiling of HT-1080 Variants Identifies uPA Activation as a Key Regulator of Tumor Cell Intravasation (2006) (0)
Proteomic Profiling of Dynamic Palmitoylation (2008) (0)
Table S4, SAR Analysis for Target: Non Aromatic sub for Phenyl (2011) (0)
Figure 5, 48 hour stability study of ML345 in PBS (2014) (0)
Role of AIG1 and ADTRP in Endogenous FAHFA Regulation (2020) (0)
Faculty Opinions recommendation of Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor. (2003) (0)
Figure 3, 1H NMR spectrum (2013) (0)
Figure 3.3-1, Covalent modification of pPAFAH by ML256 (SID 125269079) as determined by LC-MS/MS analysis (2014) (0)
Figure 5, Covalent modification of LYPLA1 by Probe ML211 (Compound 1.18, SID 99445338) (2013) (0)
Figure 9, Structures of existing LYPLA1-inhibitors (2013) (0)
Figure S1, Gel-based competitive ABPP analysis of cherry-picked HTS hits against over-expressed pPAFAH in a complex proteome (293T Hek cell lysate) at 5 μM compound concentration (AID 588474) (2014) (0)
(‐)‐FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase‐1. (2004) (0)
Table S3, SAR Analysis for Target: Benzyl sub for Phenyl (2011) (0)
Figure 12, Probe dose-response curve, IDE inhibition (AID 624065, SID 136920229) (2014) (0)
Faculty Opinions recommendation of Chemical phylogenetics of histone deacetylases. (2010) (0)
Figure 5, Competitive ABPP with clickable N-heterocyclic urea activity-based probes 6–10 (AA6–AA10) to assess general SH reactivity (2013) (0)
Translation Attenuation by Minocycline Increases Lifespan and Improves Proteostasis in Old Post-Stress-Responsive Organisms (2018) (0)
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole (2009) (0)
Competitive isoTOP-ABPP with 3 lipid derived electrophiles to map LDE-reactive cysteines in proteomes (2015) (0)
Table 3.1-1, Most promising pPAFAH inhibitor leads by gel-based competitive ABPP (2014) (0)
Identification of AADACL1 as a Novel Regulator of Human Platelets via Chemoproteomics (2012) (0)
Activity-based Proteomics: Applications for Enzyme and Inhibitor Discovery Global Profiling of Proteolytic Cleavage Sites in Apoptosis (2009) (0)
Figure 6, Potency and Selectivity of 20 Triazole Urea Synthetic Library Compounds at three compound concentrations: 1.5 μM (A), 200 nM (B), and 30 nM (C) (2013) (0)
Table 4, CYP450 Inhibition of Probe ML345 (2014) (0)
CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE (2002) (0)
Figure 2, Structures of prior-art ABHD6 carbamate inhibitors (2013) (0)
Mapping endocannabinoid signaling networks in the mammalian brain (2012) (0)
Figure 14, Proteome-wide activity-based protein profiling for cysteine reactivity of ML345 (2014) (0)
Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry (2021) (0)
Faculty Opinions recommendation of Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. (2008) (0)
Figure 8, Potency and selectivity of triazole urea synthetic library compounds at three compound concentrations (2013) (0)
[Table], Batch data, IDE Inhibitor Probe (2014) (0)
Table 1, Compounds submitted to the SMR collection (04-09-2012) (2013) (0)
Figure 8, Comparative profiling of enantiomeric pairs: Compounds 1 vs. 2 and 3 vs. 4 (2011) (0)
Inhibition of cannabinoid metabolic enzymes reduces NSAID‐induced gastric pathology (2011) (0)
Discovery of a lipid deacetylase (AADACL1) as a novel regulator of platelet activation (999.4) (2014) (0)
Table S2, Target SAR Analysis: non-carbamate HTS Hits (2014) (0)
Table 3, N-heterocyclic urea compounds tested for general SH inhibition (2013) (0)
Figure 5, Selective inhibition of ABHD11 activity in situ by probe ML226 (compound 12, AA44-1, SID 99445332) (2013) (0)
Figure S2, Second Round Secondary Screening: Competitive-ABPP profiling with recombinant LYPLA2 (human) and endogenous LYPLA1 and LYPLA2 (mouse brain membrane proteome): 20 μM Test Compound (2013) (0)
Author response: A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation (2015) (0)
murine colon: impact on electrophysiology Structural differences in the enteric neural network in (2006) (0)
N-Acyl Taurines Are Fish Oil-Regulated Biliary Lipids That Lower Lipid Absorption And Plasma Tg (2019) (0)
Erratum: Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes (2009) (0)
Figure 11, ML345 is a fluorinated analog of CID 2325815 (2014) (0)
Faculty Opinions recommendation of Discovery of the chemical function of glycosidases: design, synthesis, and evaluation of mass-differentiated carbohydrate libraries. (2004) (0)
Figure 13, Lipiniski and other drug-likeness parameters for ML345 (2014) (0)
Profiles d'activite enzymatique (2002) (0)
Table A2.1, Comparative data on similar compound structures establishing SAR (right-hand derivatization) (2010) (0)
Glycolytic Metabolite Functional Lysine Modification by an Intrinsically Reactive Primary (2014) (0)
Figure 7, Potency and selectivity of triazole urea synthetic library compounds 1–20 at three compound concentrations: 1.5 μM (A), 200 nM (B), and 30 nM (C) (2013) (0)
Table 1, Overview of PubChem assays for the LYPLA1 inhibitor project (2013) (0)
Biochanin A acts as a peripheral inhibitor of fatty acid amide hydrolase (2009) (0)
[Table, Probe Report for PME-1 Inhibitors]. (2010) (0)
Selected Classes of Bioactive Peptides (2009) (0)
Quantitative Chemical Proteomics of Dynamic Palmitoylation (2010) (0)
Figure 3, Stability of ML136 (Compound 1) in PBS indicates a half-life of >48 hours (2010) (0)
Figure 5, Competitive-ABPP vs. Click Chemistry (CC)-ABPP to assess probe and analog selectivity, MDA-MB-435 soluble proteome (2011) (0)
Figure S5, Competitive-ABPP profiling with endogenous GSTO1 in MDA-MB-435 soluble proteome: Synthetic Analogs (2011) (0)
Table 2, Top Inhibitors from 2ary Screen (2013) (0)
[Table, Scientific Rationale for Project]. (2010) (0)
Table S5, SAR Analysis for Target: Ring-Constrained acetamides (2011) (0)
Figure 4, HPLC Spectrum of ML345 at various wavelengths; purity >98% (2014) (0)
Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 (2022) (0)

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