Benjamin G. Covino
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Medical Philosophy
Benjamin G. Covino's Degrees
- PhD Pharmacology University of California, San Francisco
- Doctorate Medicine Stanford University
Why Is Benjamin G. Covino Influential?
(Suggest an Edit or Addition)Benjamin G. Covino's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Comparative Systemic Toxicity of Convulsant and Supraconvulsant Doses of Intravenous Ropivacaine, Bupivacaine, and Lidocaine in the Conscious Dog (1989) (309)
- Pharmacology of local anaesthetic agents. (1986) (293)
- Local anesthetics : mechanisms of action and clinical use (1976) (278)
- Analgesic responses to i.v. lignocaine. (1982) (212)
- Acute Cardiovascular Toxicity of Intravenous Amide Local Anesthetics in Anesthetized Ventilated Dogs (1982) (186)
- Comparative Motor‐Blocking Effects of Bupivacaine and Ropivacaine, A New Amino Amide Local Anesthetic, in the Rat and Dog (1988) (179)
- Differential Sensitivities of Mammalian Nerve Fibers to Local Anesthetic Agents (1980) (168)
- Comparison of Bupivacaine‐and Ropivacaine‐Induced Conduction Blockade in the Isolated Rabbit Vagus Nerve (1989) (167)
- Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. (1990) (165)
- Principles and Practice of Anesthesiology (1994) (162)
- Effects of Fentanyl and Sufentanil on Peripheral Mammalian Nerves (1987) (157)
- Comparative CNS Toxicity of Lidocaine, Etidocaine, Bupivacaine, and Tetracaine in Awake Dogs Following Rapid Intravenous Administration (1983) (147)
- Physical insulation of Korean diving women. (1962) (146)
- Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. (1991) (145)
- A Dose‐Response Study of Bupivacaine for Spinal Anesthesia (1983) (143)
- Pharmacology of Local Anesthetic Agents (1981) (112)
- Comparative Pharmacokinetics of Bupivacaine and Ropivacaine, a New Amide Local Anesthetic (1988) (112)
- A New Local Anesthetic, Ropivacaine: Its Epidural Effects in Humans (1990) (108)
- Chronotropic and Inotropic Effects of Ropivacaine, Bupivacaine, and Lidocaine in the Spontaneously Beating and Electrically Paced Isolated, Perfused Rabbit Heart (1992) (101)
- Effect of baricity on spinal anaesthesia with amethocaine. (1980) (99)
- Differential sensitivities of mammalian nerve fibers during pregnancy. (1983) (89)
- Effect of Local Anesthetic Agents on Cardiac Conduction and Contractility (1981) (87)
- Cardiac Electrophysiologic Effects of Lidocaine and Bupivacaine (1988) (85)
- Does pregnancy alter the systemic toxicity of local anesthetics? (1989) (84)
- Vasoconstrictors in Spinal Anesthesia with Tetracaine—A Comparison of Epinephrine and Phenylephrine (1984) (75)
- Toxicity of Lidocaine in Adult, Newborn, and Fetal Sheep (1981) (74)
- Toxicity and Systemic Effects of Local Anesthetic Agents (1987) (70)
- Interpleural regional analgesia. (1988) (67)
- Effect of Pregnancy on Bupivacaine‐Induced Conduction Blockade in the Isolated Rabbit Vagus Nerve (1986) (65)
- Effects of anesthesia (1985) (64)
- Comparative Clinical Pharmacology of Local Anesthetic Agents (1971) (62)
- Toxicity of local anesthetic agents. (1988) (61)
- Prolonged sensory/motor deficits following inadvertent spinal anesthesia. (1980) (61)
- Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics (1986) (58)
- Differential Sensitivities of Mammalian Nerve Fibers during Pregnancy (1983) (50)
- PLASMA LIGNOCAINE CONCENTRATIONS FOLLOWING ENDOTRACHEAL SPRAYING WITH AN AEROSOL (1976) (50)
- Influence of Lidocaine and Bupivacaine on Isolated Guinea Pig Atria in the Presence of Acidosis and Hypoxia (1982) (50)
- Antiarrhythmic Effectiveness of Intramuscular Lidocaine: Influence of Different Injection Sites (1974) (50)
- Systemic toxicity of ropivacaine during ovine pregnancy. (1991) (47)
- Differential Sensitivity of Fast and Slow Fibers in Mammalian Nerve III. Effect of Etidocaine and Bupivacaine on Fast/Slow Fibers (1982) (46)
- Plasma concentrations of local anaesthetics after interscalene brachial plexus block. (1978) (46)
- Effect of progesterone on the cardiac electrophysiologic alterations produced by ropivacaine and bupivacaine. (1992) (45)
- Pharmacokinetics of local anaesthetics (1991) (45)
- Effects of concentration of local anaesthetic drugs in extradural block. (1980) (45)
- PLASMA CONCENTRATIONS OF LOCAL ANAESTHETICS AFTER INTERSCALENE BRACHIAL PLEXUS BLOCK (1977) (44)
- Pharmacokinetics of Lidocaine in Fetal and Neonatal Lambs and Adult Sheep (1979) (44)
- Racial variations to a standardized cold stress. (1958) (44)
- Ventricular fibrillation in the hypothermic dog. (1954) (42)
- Patient-controlled analgesia (1990) (40)
- Developmental neurophysiology of mammalian peripheral nerves and age-related differential sensitivity to local anaesthetic. (1988) (40)
- Toxicity and Distribution of Lidocaine in Nonasphyxiated and Asphyxiated Baboon Fetuses (1981) (39)
- Handbook of epidural anaesthesia and analgesia (1985) (39)
- Epidural Morphine Provides Postoperative Pain Relief in Peripheral Vascular and Orthopedic Surgical Patients: A Dose—Response Study (1986) (38)
- Electrolytes and pH Changes in Relation to Hypothermic Ventricular Fibrillation (1955) (38)
- Effects of progesterone on the cardiac electrophysiologic action of bupivacaine and lidocaine. (1992) (38)
- Differential nerve blocking activity of amino-ester local anaesthetics. (1985) (37)
- Effectiveness of several antifibrillary drugs in the hypothermic dog. (1955) (35)
- Physical regulation of temperature in Eskimos. (1962) (35)
- Cardiac electrophysiologic effects of articaine compared with bupivacaine and lidocaine. (1993) (35)
- Differential nerve blockade: esters v. amides and the influence of pKa. (1987) (32)
- Absorption of Lidocaine following Subarachnoid and Epidural Administration (1979) (32)
- Adverse Effects of Maternally Administered Lidocaine on the Asphyxiated Preterm Fetal Lamb (1989) (30)
- Physiology and pharmacology of local anesthetic agents. (1981) (29)
- The Effects of Epinephrine on the Anesthetic and Hemodynamic Properties of Ropivacaine and Bupivacaine after Epidural Administration in the Dog (1991) (27)
- Systemic toxicity of local anesthetic agents. (1978) (27)
- Ventricular excitability cycle: its modification by pH and hypothermia. (1955) (25)
- Effect of Pregnancy on Bupivacaine-Induced Conduction Blockade in the Isolated Rabbit Vagus Nerve (1987) (25)
- Pregnancy does not alter lidocaine toxicity. (1990) (25)
- Myocardial metabolic and electrical properties of rabbits and ground squirrels at low temperatures. (1959) (25)
- Blood levels of lidocaine following subcutaneous administration prior to cardiac catheterization. (1974) (24)
- Determinants of etidocaine concentration in the blood. (1975) (23)
- Changes in cardiac contractility during immersion hypothermia. (1958) (23)
- Differential Sensitivity of Fast and Slow Fibers in Mammalian Nerve II. Margin of Safety for Nerve Transmission (1982) (23)
- Effect of ropivacaine and bupivacaine on uterine blood flow in pregnant ewes. (1992) (23)
- ACUTE IV TOXICITY OF LEA-103, A NEW LOCAL ANESTHETIC, COMPARED TO LIDOCAINE AND BUPIVACAINE IN THE AWAKE DOG (1986) (22)
- The Cardiovascular Effects of Convulsant Doses of Lidocaine and Bupivacaine in the Conscious Dog (1985) (22)
- Observed and predicted accumulation of local anaesthetic agents during continuous extradural analgesia. (1977) (21)
- Plasma lignocaine concentrations following endotracheal spraying with an aerosol. (1977) (21)
- Absorption of lidocaine following subarachnoid and epidural administration. (1979) (20)
- Does Pregnancy Alter the Systemic Toxicity of Local Anesthetics (1990) (20)
- Pharmacokinetics of Ropivacaine in Nonpregnant and Pregnant Ewes (1988) (18)
- The Effect of Methylene Blue on Neural Tissue (1970) (18)
- Comparison of carbonated bupivacaine and bupivacaine hydrochloride for extradural anaesthesia. (1980) (17)
- Handbook of Spinal Anaesthesia and Analgesia (1994) (17)
- Effect of Hypothermia on Ventricular Fibrillary Threshold (1957) (17)
- Comparative anaesthetic properties of various local anaesthetic agents in extradural block for labour. (1978) (17)
- COMPARATIVE ANAESTHETIC PROPERTIES OF VARIOUS LOCAL ANAESTHETIC AGENTS IN EXTRADURAL BLOCK FOR LABOUR (1977) (16)
- Recent advances in local anaesthesia (1986) (15)
- Effect of lidocaine on the asphyxial responses in the mature fetal lamb. (1987) (14)
- Bradycardia in the fetal baboon following paracervical block anesthesia. (1981) (14)
- A Double-blind Evaluation of Intrathecal Bupivacaine Without Glucose and a Standard Solution of Hyperbaric Tetracaine (1984) (14)
- Comparative Study of Various Local Anaesthetic Solutions in Extradural Block in Labour (1979) (14)
- Effects of adrenaline and the concentration of solution on extradural block with etidocaine. (1978) (13)
- Evaluation of Etidocaine, A New Local Anesthetic Agent, with a Modified Bilateral Ulnar-nerve-block Technique (1974) (12)
- MODIFICATION OF THE CIRCULATORY EFFECTS OF EXTRADURAL BLOCK COMBINED WITH GENERAL ANAESTHESIA BY THE ADDITION OF ADRENALINE TO LIGNOCAINE SOLUTIONS (1977) (12)
- CARDIAC ELECTROPHYSIOLOGIC EFFECTS OF A NEW LONG ACTING LOCAL ANESTHETIC AGENT (LEA-103) (1986) (11)
- EFFECT OF EXOGENOUSLY ADMINISTERED PROGESTERONE ON SUSCEPTIBILITY OF RABBIT VAGUS NERVES TO BUPIVACAINE (1988) (11)
- CARDIAC EFFECTS OF SYNTHETIC OXYTOCIN (SYNTOCINON). (1963) (10)
- EVALUATION OF ACUTE CARDIOVASCULAR EFFECTS OF ESMOLOL IN THE DOG–AWAKE AND ANESTHETIZED WITH HALOTHANE AND ENFLURANE (1984) (10)
- Local anesthesia. 2. (1972) (10)
- THE MARGIN OF SAFETY FOR TRANSMISSION IN FAST AND SLOW NERVE FIBERS (1980) (10)
- Comparative antiarrhythmic effects of intravenously administered lidocaine and procainamide and orally administered quinidine (1970) (9)
- Differential Sensitivity of Fast and Slow Fibers in Mammalian Nerve: IV. Effect of Carbonation of Local Anesthetics (LA) (1985) (9)
- Ultralong-acting local anesthetic agents. (1981) (9)
- Local anesthetic agents for peripheral nerve blocks. (1980) (9)
- COMPARATIVE CARDIAC EFFECTS OF QUINIDINE AND N,N-BIS(PHENYLCARBAMOYLMETHYL)-DIMETHYLAMMONIUM CHLORIDE (QX-572), A NEW ANTIARRHYTHMIC AGENT. (1964) (9)
- TOXIC CARDIAC ELECTROPHYSIOLOGIC EFFECTS OF BUPIVACAINE AND LIDOCAINE AT HIGH CONCENTRATIONS (1985) (9)
- Effect of various drugs on spontaneous and surgically induced ventricular fibrillation in hypothermia. (1959) (9)
- Hind limb blood flow during immersion hypothermia. (1957) (9)
- Distribution of Local Anesthetics in Man Following Peridural Anesthesia (1967) (9)
- Clinical evaluation of local anaesthetic agents. (1975) (9)
- A Clinical Double‐Blind Study of Dibucaine and Tetracaine in Spinal Anesthesia (1982) (9)
- Relationship of fetal bradycardia to maternal administration of lidocaine in sheep. (1979) (9)
- Pharmacokinetics of Etidocaine in Fetal and Neonatal Lambs and Adult Sheep (1982) (8)
- Does gestational age affect the pharmacokinetics and pharmacodynamics of lidocaine in mother and fetus (1988) (8)
- ACUTE CARDIOVASCULAR TOXICITY OF LIDOCAINE, BUPIVICAINE AND ETIDOCAINE IN ANESTHETIZED, VENTILATED DOGS (1980) (8)
- Pharmacology of Newer Local Anesthetic Agents (1978) (8)
- EditorialPotential neurotoxicity of local anaesthetic agents (1983) (8)
- Clinical pharmacology of N,N-bis(phenylcarbamolymethyl)dimethylammonium chloride (QX-572), a new antiarrhythmic agent. (1967) (8)
- Ventricular diastolic threshold in hypothermia. (1955) (8)
- LOCAL ANESTHETIC EFFICACY OF LEA 103 - AN EXPERIMENTAL XYLIDIDE AGENT (1986) (8)
- Effect of hypothermia on the cellular respiration of ventricular tissue. (1957) (7)
- Modification of the circulatory effects of extradural block combined with general anaesthesia by the addition of adrenaline to lignocaine solutions. (1978) (7)
- Effects of oral glycine during cold exposure in man. (1959) (7)
- PHARMACOKINETICS OF BUPIVACAINE IN CHILDREN FOLLOWING INTERCOSTAL BLOCK (1982) (7)
- Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions (1988) (7)
- Effect of cold on the isolated and intact rabbit heart. (1958) (7)
- Interaction of Diazepam and Epidurally Administered Local Anesthetic Agents (1980) (7)
- Cardiovascular effects of spinal and epidural anesthesia. (1978) (6)
- Pharmacodynamic and pharmacokinetic aspects of local anesthetics. (1984) (6)
- Local anesthesia. 1. (1972) (6)
- PROGESTERONE-INDUCED INCREASEIN CARDIAC SENSITIVITY TO BUPIVACAINE (1988) (6)
- Reappraisal of ventricular thresholds in hypothermia. (1956) (6)
- Cardiovascular response to hypothermia: effect of cold acclimatization. (1957) (6)
- Distribution of local anesthetics in man following peridural anesthesia. (1969) (6)
- Relationship of potassium and calcium to hypothermic ventricular fibrillation. (1959) (6)
- Excitability cycle of the ventricle in hypothermia. (1955) (6)
- Clinical tolerance and effectiveness of propitocaine, a new local anesthetic agent. (1965) (6)
- Cardiovascular functions in the dog rewarmed rapidly and slowly from deep hypothermia. (1960) (5)
- Ventricular Excitability During Hypothermia and Rewarming in the Dog.∗ (1955) (5)
- EFFECTS OF ASPHYXIA ON THE PHARMACODYNAMICS OF LIDOCAINE IN THE MATURE FETAL LAMB (1985) (5)
- Effect of Lidocaine on the Asphyxial Responses in the Mature Fetal Lamb (1987) (5)
- Pharmacology of local anesthetic agents. (1981) (5)
- A827 TREATMENT OF ACUTE TOXICITY AFTER RAPID INTRAVENOUS ROPIVACAINE AND BUPIVACAINE IN THE CONSCIOUS DOG (1990) (5)
- Hypothermic ventricular fibrillation and its control. (1956) (4)
- Is there a need for chloroprocaine 3% and bupivacaine 0.75%? (1988) (4)
- Comparative antiarrhythmic effects of intravenously administered lidocaine and procainamide and orally administered quinidine. (1972) (4)
- DIFFERENTIAL SENSITIVITY OF FAST AND SLOW FIBER IN MAMMALIAN NERVE EFFECT OF PH AND PCO2 (1982) (4)
- Epidural block with etidocaine for labour and delivery. (1975) (4)
- EFFECT OF GENERAL AND REGIONAL ANESTHESIA ON TOURNIQUET INDUCED HYPERTENSION (1984) (3)
- Effect of Vasoconstrictor Agents on the Duration of Action of Intrathecal Tetracaine, Bupivacaine and Lidocaine in the Dog (1985) (3)
- Hemodynamic Effects of Local Anesthetic Agents (1986) (3)
- Aminoacetic acid (glycine) as an antifibrillary agent in hypotermia. (1957) (3)
- One Hundred Years Plus Two of Regional Anesthesia (1986) (3)
- DOSE RESPONSE STUDY OF BUPIVACAINE IN SPINAL ANESTHESIA (1982) (3)
- Effect of several new antiarrhythmic agents on atrial contractility. (1969) (3)
- Differential Sensitivities of Mammalian Nerve Fibers during Pregnancy in Relation to Different Concentrations of Bupivacaine (1984) (3)
- Potential neurotoxicity of local anaesthetic agents. (1983) (3)
- Pharmacokinetic Interaction of Local Anesthetics and Diazepam (1981) (3)
- Toxicity of Intravenously Administered Local Anesthetic Agents in the Dog (1986) (3)
- Bupivacaine with and without epinephrine for intercostal nerve blocks (1988) (3)
- Peripheral vascular responses to frostbite as influenced by alcohol. (1953) (3)
- Autifibrillary effect of mephentermine sulfate (wyamine) in general hypothermia. (1958) (3)
- PHARMACOKINETICS OF ROPIVACAINE AND BUPIVACAINE IN PREGNANT EWES (1991) (2)
- Serum protein binding of ropivacaine in nonpregnant and pregnant ewes. (1990) (2)
- EFFECT OF LOCAL ANESTHETIC DRUGS ON FAST AND SLOW NERVE FIBERS (1979) (2)
- Ropivacaine and bupivacaine for epidural anesthesia (1990) (2)
- EFFECT OF PREGNANCY ON LIDOCAINE PHARMACOKINETICS IN SHEEP (1985) (2)
- Differential Sensitivity of Fast and Slow Fibers in Mammalian Nerve: VI. Effect of pH on Blocking Action of Local Anesthetics (LA) (1986) (2)
- Hypertonic saline reverses bupivacaine-induced depression of rabbit Purkinje fiber depolarization Vmax. (1989) (2)
- IS ETIDOCAINE MORE CARDIOTOXIC THAN LIDOCAINE (1982) (2)
- Effects of Baricity and Concentration of Tetracaine Solutions on Experimental Spinal Anesthesia in Sheep (1981) (2)
- Effect of progesterone on cardiac electrophysiological alteration produced by ropivacaine and bupivacaine (1992) (2)
- Pharmacology and Physiology of Local Anesthetics (1977) (2)
- Pharmacokinetics of Intravenous Regional Anesthesia (1979) (2)
- Cardiac metabolism during hypothermia. (1969) (1)
- Local anesthetic toxicity (1990) (1)
- Effects of a new beta-adrenergic receptor blocking agent, alprenolol, andts optical isomers. (1969) (1)
- CARDIOVASCULAR EFFECTS OF MEPIVACAINE AND ETIDOCAINE IN THE AWAKE DOG (1984) (1)
- THE EFFECTS OF EPIDURAL MORPHINE ON POST OPERATIVE ANALGESIA (1982) (1)
- Cardiovascular Effects of Local Anesthetics (1990) (1)
- BRADYCARDIA FOLLOWING PCB*IN THE FETAL BABOON (1980) (1)
- HIND LIMB BLOOD FLOW DURING IMMERSION HYPOTHERMIA (1957) (1)
- Local Anesthetics: Update (1991) (1)
- Pharmacologic Basis of Arrhythmia Management (1983) (1)
- THE EFFECT OF CONVULSIONS ON LIDOCAINE AND BUPIVACAINE PHARMACOKINETICS IN THE DOG (1984) (1)
- Eupivacaine With and Without Epinephrine for Intercostal Nerve Blocks (1987) (1)
- AGE-RELATED DIFFERENCES IN CARDIOTOXICITY AND TISSUE CONCENTRATIONS OF LIDOCAINE IN SHEEP (1982) (1)
- A844 EFFECTS OF ROPIVACAINE, BUPIVACAINE, AND LIDOCAINE UPON THE ISOLATED SPONTANEOUSLY BEATING RABBIT HEART (1990) (1)
- New developments in the field of local anesthetics and the scientific basis for their clinical use. (1982) (1)
- Cardiovascular Effects of Total Spinal Anesthesia Following Intrathecal Administration of Bupivacaine with and Without Epinephrine in the Dog (1984) (1)
- COMPARATIVE EFFICACY OF POST-OPERATIVE PAIN CONTROL TECHNIQUES (1991) (1)
- Current status of antiarrhythmic drug therapy. (1968) (1)
- A comparison of carotid angioplasty with stenting versus endarterectomy with regional anesthesia. (1999) (1)
- Benjamin G. Covino, Ph.D., M.D. (1991) (1)
- Regarding “A comparison of carotid angioplastywith stenting versus endarterectomy with regional anesthesia” (1999) (1)
- Regional Anesthesia for Patients with Cardiac Disease (1990) (0)
- Prospective advances in local anesthesia [proceedings]. (1978) (0)
- Pregnancy Does Not Alter Lidocaine Toxicity (1991) (0)
- LIDOCAINE TOXICITY IN PREGNANT SHEEP (1988) (0)
- Pharmacokinetics of Intravenous Regional Anesthesia (1990) (0)
- Regional Anesthesia for the Management of Post-Operative Pain (1991) (0)
- Manual de analgesia y anestesia epidurales (1988) (0)
- Direct effects of pentylenetetrazol on cardiac tissue. (1962) (0)
- Letters to the Editor (1988) (0)
- Antiarrhythmic effectiveness of alprenolol, a new beta adrenergic receptor blocking agent. (1970) (0)
- DIFFERENTIAL SENSITIVITY OF FIBERS IN MAMMALIAN NERVE ONSET AND OFFSET OF LOCAL ANESTHETIC BLOCK (1982) (0)
- Interaction of Diazepam and Epidurally Administered Local Anesthetic Agents (1990) (0)
- THE DIFFERENTIAL NERVE BLOCKING ACTIVITY OF AMINO-ESTER LOCAL ANESTHETICS (1984) (0)
- Regional Anesthesia: Past Accomplishments and Future Needs (1981) (0)
- Physiologic Disposition of Local Anesthetic Agents (1990) (0)
- Alterations in the Pharmacokinetic Properties of Amide Local Anesthetics Following Local Anesthetic Induced Convulsions (1989) (0)
- Acute Effects of Progesterone on Conduction Blockade in the Isolated Rabbit Vagus Nerve (1989) (0)
- MATERNAL AND FETAL UPTAKE OF BUPIVACAINE vs. LIDOCAINE AT STEADY STATE PLASMA DRUG CONCENTRATIONS (1987) (0)
- Book ReviewIllustrated Handbook in Local Anesthesia (1980) (0)
- SYSTEMIC TOXICITY OF ROPIVACAINE IN PREGNANT AND NONPREGNANT EWES (1988) (0)
- CHOICE OF DRUGS FOR SPINAL AND EPIDURAL ANESTHESIA (1986) (0)
- Physiologic Disposition of Local Anesthetic Agents (1990) (0)
- DOES PREGNANCY ALTER MEPIVACAINE TOXICITY (1986) (0)
- Effect of cold on the isolated perfused mammalian heart. (1960) (0)
- Bupivacaine Cardiotoxicity Is Related to Increased Brain Sensitivity (1986) (0)
- Physiologic Disposition of Local Anesthetic Agents (1977) (0)
- Hypertonic saline effects on normal cardiac electrophysiology (1988) (0)
- Regional Anesthesia and Analgesia: An Idea Whose Time has Returned (1989) (0)
- Physiology and Pharmacology of Local Anesthetic Agentst (2007) (0)
- Effect of antiarrhythmic agents on cardiac metabolism. (1968) (0)
- Passing the Torch (1982) (0)
- A953 ESTROGEN-INDUCED INCREASE IN CARDIAC SENSITIVITY TO BUPIVACAINE (1990) (0)
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