Benjamin L. Ebert
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American oncologist
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Philosophy Biology
Benjamin L. Ebert's Degrees
- Doctorate Medicine Harvard University
- PhD Genetics Harvard University
Why Is Benjamin L. Ebert Influential?
(Suggest an Edit or Addition)According to Wikipedia, Benjamin Levine Ebert is the Chair of Medical Oncology at the Dana–Farber Cancer Institute and the George P. Canellos, MD and Jean S. Canellos Professor of Medicine at Harvard Medical School. Early life and education Ebert was born in Boston Lying-In Hospital to parents Michael and Ellen Ebert. His father was the Chair of the department of psychiatry at Vanderbilt University School of Medicine while his mother was an artist. Due to his fathers position, Ebert and his family lived in Baltimore, Maryland, and Bethesda, Tennessee. While in Tennessee, Ebert was enrolled at the University School of Nashville where he was ranked nationally in table tennis. During high school, he also worked in the laboratory of Daryl Granner and studied gene regulation and diabetes.
Benjamin L. Ebert's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles (2005) (33800)
- MicroRNA expression profiles classify human cancers (2005) (9561)
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells (2014) (4016)
- Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. (2017) (3878)
- The landscape of somatic copy-number alteration across human cancers (2010) (3297)
- Age-related clonal hematopoiesis associated with adverse outcomes. (2014) (2967)
- Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. (2005) (2933)
- Clinical effect of point mutations in myelodysplastic syndromes. (2011) (1433)
- Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease (2017) (1358)
- Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. (2015) (1351)
- MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia (2006) (1325)
- Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation (2014) (1292)
- Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells (2014) (1176)
- Bone progenitor dysfunction induces myelodysplasia and secondary leukemia (2010) (1023)
- Stem cell gene expression programs influence clinical outcome in human leukemia (2011) (916)
- Identification of RPS14 as a 5q- syndrome gene by RNA interference screen (2007) (902)
- Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis (2011) (887)
- Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. (2009) (701)
- Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. (2015) (697)
- Ribosomopathies: human disorders of ribosome dysfunction. (2010) (691)
- Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. (2015) (652)
- (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible (2013) (637)
- Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences (*) (1995) (579)
- Hypoxic Regulation of Lactate Dehydrogenase A (1995) (564)
- Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS (2015) (564)
- Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. (1994) (509)
- TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. (2014) (491)
- Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (2015) (489)
- Prognostic Mutations in Myelodysplastic Syndrome after Stem‐Cell Transplantation (2017) (470)
- The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia (2016) (470)
- Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing (2014) (439)
- Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. (2012) (436)
- Clonal hematopoiesis in human aging and disease (2019) (406)
- Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. (2011) (359)
- Integrative genomic analysis of HIV-specific CD8+ T cells reveals that PD-1 inhibits T cell function by upregulating BATF (2010) (350)
- Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. (2014) (344)
- MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. (2008) (338)
- A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms (2009) (331)
- Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia (2010) (331)
- Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. (2014) (329)
- Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. (2010) (320)
- The impact of the COVID-19 pandemic on cancer care (2020) (311)
- Heterodimeric JAK-STAT Activation as a Mechanism of Persistence to JAK2 Inhibitor Therapy (2011) (309)
- Unraveling the molecular pathophysiology of myelodysplastic syndromes. (2011) (301)
- Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing (2011) (298)
- Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. (1995) (284)
- Regulation of Transcription by Hypoxia Requires a Multiprotein Complex That Includes Hypoxia-Inducible Factor 1, an Adjacent Transcription Factor, and p300/CREB Binding Protein (1998) (280)
- Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation. (2016) (278)
- Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma. (2017) (270)
- The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. (2011) (269)
- Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms (2018) (255)
- International Consensus Classification of Myeloid Neoplasms and Acute Leukemia: Integrating Morphological, Clinical, and Genomic Data. (2022) (249)
- Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (2019) (237)
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN (2018) (229)
- Diagnosis and Management of AML in Adults: 2022 ELN Recommendations from an International Expert Panel. (2022) (218)
- Cancer therapy shapes the fitness landscape of clonal hematopoiesis (2020) (218)
- The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. (2016) (213)
- Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome (2018) (210)
- Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. (2011) (208)
- Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia (2013) (204)
- Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. (2007) (203)
- Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo (2006) (197)
- A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies (2019) (195)
- Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. (2008) (185)
- Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. (2020) (184)
- Inherited Causes of Clonal Hematopoiesis in 97,691 TOPMed Whole Genomes (2020) (184)
- Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease (2010) (181)
- pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. (2007) (180)
- Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9 (2016) (177)
- Mutations in epigenetic regulators including SETD2 are gained during relapse in pediatric acute lymphoblastic leukemia (2014) (174)
- Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML (2016) (173)
- An Erythroid Differentiation Signature Predicts Response to Lenalidomide in Myelodysplastic Syndrome (2008) (170)
- Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. (2014) (168)
- Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin. (1996) (153)
- Metagene projection for cross-platform, cross-species characterization of global transcriptional states (2007) (152)
- In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. (2013) (152)
- L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. (2012) (150)
- Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo. (2006) (147)
- The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis (2021) (145)
- Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. (2017) (142)
- Proposed minimal diagnostic criteria for myelodysplastic syndromes (MDS) and potential pre-MDS conditions (2017) (141)
- TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups (2019) (141)
- The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K (2020) (139)
- Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. (2013) (137)
- Genomic approaches to hematologic malignancies. (2004) (136)
- miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells (2016) (135)
- Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations. (2018) (134)
- PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells. (2018) (125)
- Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs (2014) (124)
- The novel mechanism of lenalidomide activity. (2015) (123)
- Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. (2018) (114)
- Clonal Hematopoiesis: Crossroads of Aging, Cardiovascular Disease, and Cancer: JACC Review Topic of the Week. (2019) (113)
- Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome. (2011) (107)
- An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. (2004) (106)
- miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells (2016) (102)
- Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. (2013) (102)
- Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer (2009) (102)
- Clinical Implications of Genetic Mutations in Myelodysplastic Syndrome. (2017) (100)
- The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. (2010) (100)
- Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing. (1995) (99)
- SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS (2020) (98)
- Somatic Mutations in MDS Patients Are Associated with Clinical Features and Predict Prognosis Independent of the IPSS-R: Analysis of Combined Datasets from the International Working Group for Prognosis in MDS-Molecular Committee (2015) (95)
- Implantable microenvironments to attract hematopoietic stem/cancer cells (2012) (91)
- Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors (2017) (89)
- Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide (2021) (87)
- Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms. (2015) (86)
- Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis. (2011) (86)
- SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia. (2017) (85)
- Molecular pathophysiology of myelodysplastic syndromes. (2013) (84)
- TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype. (2020) (83)
- Small molecule-induced polymerization triggers degradation of BCL6 (2020) (83)
- Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations (2017) (80)
- EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. (2015) (80)
- Identification of an Evolutionarily Conserved Transcriptional Signature of CD8 Memory Differentiation That Is Shared by T and B Cells1 (2008) (78)
- Genomic subtyping and therapeutic targeting of acute erythroleukemia (2019) (73)
- Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance (2014) (72)
- Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia (2014) (72)
- Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. (2019) (71)
- Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism (2015) (70)
- Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells (2017) (69)
- SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM). (2020) (68)
- Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2021) (68)
- MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. (2016) (68)
- Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts (2011) (67)
- Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. (2012) (67)
- Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability (2017) (67)
- Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera. (2012) (66)
- CHIP (Clonal Hematopoiesis of Indeterminate Potential). (2018) (66)
- Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant (2020) (65)
- Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. (2018) (63)
- Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure. (2021) (63)
- Distinction of lymphoid and myeloid clonal hematopoiesis (2021) (62)
- The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. (2017) (62)
- Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection (2021) (61)
- Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF‐1 binding sites (1996) (61)
- Molecular dissection of the 5q deletion in myelodysplastic syndrome. (2011) (61)
- Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia. (2017) (59)
- Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice. (2018) (58)
- NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes (2013) (58)
- A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. (2019) (55)
- The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. (2016) (53)
- The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders (2014) (53)
- Lenalidomide induces degradation of IKZF1 and IKZF3 (2014) (53)
- Deletion 5q MDS: molecular and therapeutic implications. (2013) (52)
- The biology and clinical impact of genetic lesions in myeloid malignancies. (2013) (52)
- Rapid and deep-scale ubiquitylation profiling for biology and translational research (2020) (51)
- Clonal Hematopoiesis and Measurable Residual Disease Assessment in Acute Myeloid Leukemia. (2020) (51)
- Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women (2020) (49)
- Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines. (1994) (49)
- Use of temozolomide with other cytotoxic chemotherapy in the treatment of patients with recurrent brain metastases from lung cancer. (2003) (48)
- Oxygen regulated gene expression: erythropoietin as a model system. (1997) (47)
- Regulation of the erythropoietin gene. (1995) (47)
- Association of clonal hematopoiesis with chronic obstructive pulmonary disease (2021) (47)
- CDK6 Antagonizes p53-Induced Responses during Tumorigenesis. (2018) (45)
- Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis (2021) (45)
- Clonal Hematopoiesis as a Model for Premalignant Changes During Aging. (2019) (45)
- CHIP, CCUS, and Other Acronyms: Definition, Implications, and Impact on Practice. (2019) (43)
- Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide (2021) (43)
- The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. (2010) (43)
- Ribosome defects in disorders of erythropoiesis (2011) (43)
- Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation. (2019) (39)
- Clonal Hematopoiesis Is Associated With Higher Risk of Stroke (2021) (38)
- Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation. (2020) (37)
- Genomic Biomarkers to Predict Resistance to Hypomethylating Agents in Patients With Myelodysplastic Syndromes Using Artificial Intelligence (2019) (37)
- The impact of the COVID-19 pandemic on cancer care (2020) (37)
- Patterns of substrate affinity, competition and degradation kinetics underlie biological activity of thalidomide analogs. (2019) (35)
- The genetic basis of myelodysplastic syndromes. (2010) (35)
- Intergenerational epigenetic inheritance of cancer susceptibility in mammals (2019) (35)
- An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites (2016) (35)
- A decade of progress in myelodysplastic syndrome with chromosome 5q deletion (2018) (35)
- Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia. (2016) (33)
- Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis (2014) (33)
- National Trends in Hospitalizations for Sickle Cell Disease in the United States Following the FDA Approval of Hydroxyurea, 1998–2008 (2014) (32)
- L‐Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q‐ syndrome in a TP53‐independent way (2014) (31)
- Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells. (2017) (31)
- Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome (2019) (31)
- Clonal hematopoiesis and blood-cancer risk. (2015) (31)
- Power cut: inhibiting mitochondrial translation to target leukemia. (2011) (30)
- Myeloproliferative neoplasm animal models. (2012) (30)
- Clonal Hematopoiesis Confers Predisposition to Both Cardiovascular Disease and Cancer: A Newly Recognized Link Between Two Major Killers (2018) (28)
- Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events. (2021) (28)
- Genetic deletions in AML and MDS. (2010) (26)
- The Biological Underpinnings of Namib Desert Fairy Circles (26)
- Pulmonary fibrosis, bone marrow failure, and telomerase mutation. (2012) (26)
- CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia (2020) (25)
- Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. (2021) (25)
- Ophir Shalem Genome-Scale CRISPR-Cas 9 Knockout Screening in Human Cells (2014) (24)
- Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML (2020) (24)
- An improved index for diagnosis and mortality prediction in malignancy associated hemophagocytic lymphohistiocytosis. (2021) (24)
- Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation (2019) (23)
- Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes (2019) (23)
- Coordinate Loss of a MicroRNA Mir 145 and a Protein-Coding Gene RPS14 Cooperate in the Pathogenesis of 5q- Syndrome. (2009) (22)
- Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. (2015) (22)
- Oncologic therapy shapes the fitness landscape of clonal hematopoiesis (2019) (22)
- Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2020) (21)
- Phase 1/2 trial of vorinostat in patients with sickle cell disease who have not benefitted from hydroxyurea. (2015) (21)
- Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation (2015) (21)
- Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyond. (2015) (21)
- The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor. (2020) (21)
- Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c) (2022) (20)
- Mutations in RNA splicing machinery in human cancers. (2011) (20)
- Lenalidomide Induces Ubiquitination and Degradation of CSNK1A1 in MDS with Del(5q) (2014) (20)
- Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution (2009) (20)
- MDS is a stem cell disorder after all. (2014) (19)
- Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms (2022) (19)
- TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes (2019) (18)
- New Strategies in Myelodysplastic Syndromes: Application of Molecular Diagnostics to Clinical Practice (2013) (18)
- Predicting progression to AML (2018) (18)
- TET2-mutant clonal hematopoiesis and risk of gout (2022) (18)
- Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy. (2021) (18)
- Translational medicine: ribosomopathies. (2011) (18)
- Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential (2022) (17)
- Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia (2020) (17)
- Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome. (2013) (17)
- Stress granules contribute to α-globin homeostasis in differentiating erythroid cells. (2012) (16)
- Loss-of-Function Mutations in Dnmt3a and Tet2 Lead to Accelerated Atherosclerosis and Convergent Macrophage Phenotypes in Mice (2018) (16)
- Genomic Profiling for Clinical Decision Making in Myeloid Neoplasms and Acute Leukemia. (2022) (16)
- Modeling and targeting of erythroleukemia by hematopoietic genome editing. (2021) (16)
- Association of mutations with morphological dysplasia in de novo acute myeloid leukemia without 2016 WHO Classification-defined cytogenetic abnormalities (2018) (15)
- Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor (2021) (15)
- Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1) (2019) (14)
- Clonal Hematopoiesis after Induction Chemotherapy for Acute Myeloid Leukemia. (2018) (14)
- Clonal Hematopoiesis of Indeterminate Potential. (2019) (13)
- NF1 Inactivation Revs Up Ras in Adult Acute Myelogenous Leukemia (2010) (13)
- A phase I study of lenalidomide plus chemotherapy with mitoxantrone, etoposide, and cytarabine for the reinduction of patients with acute myeloid leukemia (2018) (13)
- Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T-cell responses in a murine acute myeloid leukemia model (2021) (13)
- Chapter 43 – Hemoglobin Variants Associated With Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias (2018) (12)
- Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (2020) (12)
- Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies. (2021) (12)
- Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis (2018) (12)
- Contribution of Clonal Hematopoiesis to Adult-Onset Hemophagocytic Lymphohistiocytosis. (2020) (11)
- Janus reveals another face: the biologic rationale for targeting Janus kinase 2 in lymphoma. (2012) (11)
- Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade. (2020) (11)
- CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1. (2021) (11)
- Supplementary Notes MicroRNA Expression Profiles Classify Human Cancers (2005) (11)
- NPM1 mutation but not RUNX1 mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia lacking recurrent cytogenetic abnormalities in the revised 2016 WHO classification (2017) (11)
- Novel approaches to the treatment of sickle cell disease: the potential of histone deacetylase inhibitors (2012) (11)
- Utility of CRISPR/Cas9 systems in hematology research. (2017) (11)
- Downregulation of Ribosomal Proteins Is Seen in Non 5q-MDS (2008) (10)
- High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster (2019) (10)
- DMSO Increases Mutation Scanning Detection Sensitivity of High-Resolution Melting in Clinical Samples. (2015) (10)
- Genetics of smoking and risk of clonal hematopoiesis (2022) (10)
- Leukaemia: Vitamin C regulates stem cells and cancer (2017) (10)
- CHIPping Away at the Pathogenesis of Heart Failure. (2019) (9)
- Validation of a Prognostic Model and the Impact of SF3B1, DNMT3A, and Other Mutations in 289 Genetically Characterized Lower Risk MDS Patient Samples (2011) (9)
- TP53 Mutation Status Divides MDS Patients with Complex Karyotypes into Distinct Prognostic Risk Groups: Analysis of Combined Datasets from the International Working Group for MDS-Molecular Prognosis Committee (2014) (9)
- Jak-ing Up the Plaque's Lipid Core…and Even More. (2018) (9)
- Chapter 33 – Pathobiology of the Human Erythrocyte and Its Hemoglobins (2018) (9)
- Charting the "Splice" Routes to MDS. (2015) (9)
- MLL-AF 9 – and HOXA 9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD 1 C (2018) (9)
- Mutant Splicing Factor 3b Subunit 1 (SF3B1) Causes Dysregulated Erythropoiesis and a Stem Cell Disadvantage (2014) (9)
- ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. (2021) (9)
- Calmodulin Inhibition Rescues DBA Models with Ribosomal Protein Deficiency through Reduction of RSK Signaling (2016) (8)
- Increased mitochondrial apoptotic priming with targeted therapy predicts clinical response to re‐induction chemotherapy (2019) (8)
- Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4 activity (2018) (8)
- TP53-mediated clonal hematopoiesis confers increased risk for incident peripheral artery disease (2021) (8)
- Diamond Blackfan anemia and ribosome biogenesis: introduction. (2011) (8)
- Age-related diseases of inflammation in myelodysplastic syndrome and chronic myelomonocytic leukemia (2021) (8)
- Initial experience with L-leucine therapy in myelodysplastic syndromes with associated chromosome 5q deletion. (2013) (7)
- Activity of menin inhibitor ziftomenib (KO-539) as monotherapy or in combinations against AML cells with MLL1 rearrangement or mutant NPM1 (2022) (7)
- Some unusual paraneoplastic syndromes. Case 4. Paraneoplastic nephrotic syndrome in a patient with lung cancer. (2003) (7)
- PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation (2022) (7)
- Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer (2020) (7)
- Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background. (2019) (7)
- Detection of Recurrent Mutations by Pooled Targeted Next-Generation Sequencing in MDS Patients Prior to Treatment with Hypomethylating Agents or Stem Cell Transplantation (2012) (7)
- Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. (2021) (7)
- Functional screen of MSI 2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells (2017) (7)
- Clonal Hematopoiesis Associated with Adverse Outcomes Following Autologous Stem Cell Transplantation for Non-Hodgkin Lymphoma (2016) (6)
- The Role of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Multiple Myeloma: Immunomodulator Maintenance Post Autologous Stem Cell Transplant (ASCT) Predicts Better Outcome (2018) (6)
- An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation. (2020) (6)
- Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease (2022) (6)
- Introduction to a review series on precision hematology. (2017) (6)
- Erratum: Gli1 + Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target (Cell Stem Cell (2017) 20(6) (785–800.e8) (S1934590917300796) (10.1016/j.stem.2017.03.008)) (2018) (5)
- The Association between Clonal Hematopoiesis and Gout (2021) (5)
- Corrigendum: Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts (2013) (5)
- A deep molecular response of splenic marginal zone lymphoma to front-line checkpoint blockade (2020) (5)
- A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia. (2020) (5)
- Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity (2016) (5)
- Clonal hematopoiesis and risk of chronic liver disease (2022) (5)
- Non-del(5q) myelodysplastic syndromes-associated loci detected by SNP-array genome-wide association meta-analysis. (2019) (5)
- O-024 Next-generation sequencing of 213 MDS patient samples identifies mutation profiles associated with response to hypomethylating agents and overall survival (2013) (5)
- Inhibition of the CRBN-DDB1-CUL4-ROC1 E3 Ubiquitin Ligase Mediates the Anti-Proliferative and Immunomodulatory Properties of Lenalidomide (2012) (5)
- Aurora A Kinase Is a Novel Therapeutic Target In The Myeloproliferative Neoplasms (2013) (4)
- Obesity-Induced Inflammation Co-Operates with Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutants to Promote Leukemia Development and Cardiovascular Disease (2021) (4)
- A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic datasets (2022) (4)
- Sinister symbiosis: pathological hematopoietic-stromal interactions in CML. (2013) (4)
- Preface. The biology and treatment of myelodysplastic syndrome. (2010) (4)
- TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms (2022) (4)
- Inhibition of Casein Kinase 1 Alpha in Acute Myeloid Leukemia (2018) (4)
- Toll-like Receptor 1 Is a Candidate Therapeutic Target in Acute Myeloid Leukemia (2014) (4)
- Proteolysis Targeting Chimeras With Reduced Off-targets (2021) (4)
- Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells (2022) (3)
- Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering (2016) (3)
- Targeted Sequencing of 7 Genes Can Help Reduce Pathologic Misclassification of MDS (2020) (3)
- Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering (2016) (3)
- Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering (2016) (3)
- Abstract 2954: Immunomodulator maintenance post autologous stem cell transplant predicts better outcome in multiple myeloma patients with clonal hematopoiesis of indeterminate potential (2018) (3)
- Clonal Hematopoiesis and Atherosclerosis. (2017) (3)
- Calmodulin Inhibition Rescues the Effects of Ribosomal Protein Deficiency by Modulating p53 Activity in Models of Diamond Blackfan Anemia (2012) (3)
- Therapeutic potential of targeting haploinsufficient genes in cancer (2009) (3)
- Functional Defects In Neutrophils Derived From Ezh2 Null Mice (2013) (3)
- In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling (2011) (3)
- Evaluating Clonal Dominance in a Murine Knock-in Model of Jak2V617F MPN (2011) (3)
- Cancer Cell SRSF2 Mutations Contribute to Myelodysplasia Through Mutant-Specific Effects on Exon Recognition (2015) (3)
- TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease (2023) (3)
- Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state (2022) (3)
- Identification of germline variants in adults with hemophagocytic lymphohistiocytosis. (2020) (3)
- A new opening on aortic stenosis: predicting prognosis with clonal haematopoiesis. (2020) (2)
- Author response: Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome (2018) (2)
- Doubling Down on Mutant RAS Can MEK or Break Leukemia (2017) (2)
- Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion (2022) (2)
- Thrombosis in Myeloproliferative Neoplasms Is Linked to Increased Neutrophil Extracellular Trap (NET) Formation (2016) (2)
- Genome-Scale Screen Reveals Genes Required for Lenalidomide-Mediated Degradation of Aiolos By CRL4-CRBN (2016) (2)
- Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma (2019) (2)
- High Throughput Screen To Identify Small Molecules That Differentially Regulate Expression of the Globin Genes. (2005) (2)
- Evolution of severe (transfusion‐dependent) anaemia in myelodysplastic syndromes with 5q deletion is characterized by a macrophage‐associated failure of the eythropoietic niche (2022) (2)
- Introduction to Genomics in Hematologic Malignancy. (2017) (2)
- Characterization of Distinct Molecular Signatures in Myeloproliferative Diseases with the JAK2V617F Mutation and Wild Type JAK2. (2005) (2)
- A Novel Monoclonal Antibody Combination Plus DC/AML Fusion Vaccine Eradicates AML in an Immunocompetent Murine Model (2018) (2)
- Myelodysplastic syndromes (MDS) occurring in Agent Orange exposed individuals carry a mutational spectrum similar to that of de novo MDS (2019) (2)
- Abstract 2040: Mutations in SF3B1 lead to aberrant splicing through cryptic 3′ splice site selection and impair hematopoietic cell differentiation (2015) (2)
- Utility of CRISPR / Cas 9 systems in hematology resear ch (2017) (2)
- Genetic Alterations Predict Outcomes in Patients with Myelodysplastic Syndrome Receiving Allogeneic Hematopoietic Stem Cell Transplantation (2016) (2)
- Reduced Protein Synthesis and p53 Activation in Late-Stage Erythroblasts Mediate the Erythroid Differentiation Defect in Mice with Ribosomal Protein S14 Haploinsufficiency (2014) (2)
- Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (2021) (2)
- Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis (2022) (2)
- Point Mutations In Myelodysplastic Syndromes Are Associated with Clinical Features and Are Independent Predictors of Overall Survival (2010) (2)
- Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway? (2010) (2)
- Discovery of a Novel Mechanism of Resistance to Thalidomide Derivatives (2018) (1)
- Oncogene Cooperativity Analysis Reveals a Novel Set of Genes That Regulate the In Vivo Growth and Survival of Leukemia Stem Cells (2011) (1)
- Loss of TET2 Function in Myelodysplastic Syndrome Results in Intragenic Hypermethylation and Alterations in mRNA Splicing (2014) (1)
- Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells (2015) (1)
- Post-Transplant Vaccination with a Personalized Dendritic Cell/AML Fusion Cell Vaccine for Prevention of Relapse (2021) (1)
- Abstract PR12: Biological insights into tumor-bone marrow microenvironment interactions derived from a humanized murine model (2015) (1)
- Drug discovery using induced pluripotent stem cells identifies autophagy as a therapeutic pathway for anemia (2016) (1)
- Molecular Characterization of Adult Acute Lymphoblastic Leukemia Identifies a Subgroup with Myeloid Mutations and Pre-Existing Clonal Hematopoiesis (2022) (1)
- Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes (2014) (1)
- Single cell RNA-Seq of hematopoietic stem cells reveals a cell cycle-dependent interplay between aging and differentiation (2014) (1)
- Author response: Intergenerational epigenetic inheritance of cancer susceptibility in mammals (2019) (1)
- Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation (2014) (1)
- Genomic subtyping and therapeutic targeting of acute erythroleukemia (2019) (1)
- Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia (2012) (1)
- Myelodysplastic syndrome Rps 14 , Csnk 1 a 1 and miRNA 145 / miRNA 146 a de fi ciency cooperate in the clinical phenotype and activation of the innate immune system in the 5 q-syndrome (2019) (1)
- Engineered Bcor Mutations Lead to Acute Lymphoblastic Leukemia of Progenitor B-1 Lymphocyte Origin in a Sensitized Background (2018) (1)
- Genomic Biomarkers to Predict Response to Hypomethylating Agents in Patients with Myelodysplastic Syndromes (MDS) (2017) (1)
- Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (2021) (1)
- Niche-Based Screening Reveals Leukemia Stem Cell Specific Therapeutics (2011) (1)
- Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies. (2021) (1)
- Lineage-Specific Activation of p53 in Response to Ribosomal Haploinsufficiency in Human Bone Marrow Cells. (2009) (1)
- Generations of physician-scientists. (2018) (1)
- Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia (2022) (1)
- Reviewers for the Journal, January-June 2016. (2016) (1)
- A novel index using inflammatory markers improves the diagnosis of hemophagocytic lymphohistiocytosis in patients with hematologic malignancies. (2021) (1)
- The Recql5 Helicase Is a Novel Downstream Target of Jak2V617F and Maintains Genome Stability in Response to Replication Stress (2014) (1)
- Supplementary Material 10 (2014) (1)
- Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing (2016) (1)
- Ex Vivo expansion Of Umbilical Cord Blood CD34+ Cells Under Hypoxic Conditions Using Novel Compound#999 With Cytokines (2013) (1)
- Abstract 15355: Interleukin-1beta Inhibition Attenuates Accelerated Atherosclerosis in Mice With Tet2 Loss of Function in a Sex-dependent Fashion (2020) (1)
- Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma (2012) (1)
- Oxygen Sensing and Vascular Growth Factor Gene Expression: Comparison with Erythropoietin Regulation (1995) (1)
- An Erythroid Differentiation Gene Expression Signature Predicts Response to Lenalidomide in Myelodysplasia. (2006) (1)
- Lenalidomide Promotes CRBN-Mediated Ubiquitination and Degradation of IKZF1 and IKZF3 (2013) (1)
- L-Leucine Improves the Anemia of DBA and the 5q- Syndrome Via Activation of the mTOR Pathway in a p53-Independent Manner (2012) (1)
- Talazoparib Treatment Preferentially Depletes Cohesin-Mutant Clones in New In Vivo Models of Cohesin-Mutant Myeloid Diseases (2019) (1)
- Abstract 15575: The Clonal Hematopoiesis Mutation Jak2 V617F Aggravates NETosis and Endothelial Injury in Mouse Arteries With Erosion-like Intimas (2020) (1)
- CBL mutations promote activation of PI3K/AKT signaling via LYN kinase (2020) (1)
- Expressionof Sf3b1- K700Ein Murine B Cells Causes Pre-mRNA Splicing and Altered B Cell Differentiation and Function (2015) (1)
- Congenital X‐linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6 (2021) (1)
- SETD2 Heterozygous Loss in Leukemia Leads to Chemotherapy Resistance through Attenuation of the DNA Damage Response (2015) (1)
- Immunomodulatory therapy improves outcome in multiple myeloma patients with clonal hematopoiesis (2019) (1)
- 21 SF3B1 MUTATIONS INDUCE ABERRANT SPLICING LEADING TO A BLOCK IN ERYTHROID DIFFERENTIATION AND COMPETITIVE ADVANTAGE (2015) (1)
- Clonal hematopoiesis of indeterminate potential and risk of death from COVID-19 (2022) (1)
- Using Machine Intelligence Algorithms to Develop a Geno-Clinical Model to Predict Responses to Hypomethylating Agents in Myelodysplastic Syndromes (2016) (1)
- Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells. (2009) (1)
- STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia (2018) (1)
- Msi2 Maintains Normal Hematopoietic Stem Cell Self-Renewal (2011) (1)
- Oncogenic Mechanisms of CBL E3 Ubiquitin Ligase Mutations in Myeloid Malignancies (2019) (1)
- Clonal Cytopenias of Undetermined Significance Are Common in Cytopenic Adults Evaluated for MDS in the National MDS Study (2019) (1)
- Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling (2018) (0)
- MYELOID NEOPLASIA TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients (2014) (0)
- Title : 1 Gene-Centric Functional Dissection of Human Genetic Variation Uncovers 2 Regulators of Hematopoiesis (0)
- L-Leucine Improves the Anemia of the 5q- Syndrome Via Activation of the mTOR (mammalian target of rapamycin) Pathway (2011) (0)
- Abstract LB-118: Characterization of lineage vs. context-dependent essential genes in multiple myeloma using CRISPR-Cas9 genome editing (2017) (0)
- CHIPing away at breast cancer. (2019) (0)
- CXCR4 Has a CXCL12-Independent Essential Role in MLL-AF9 Driven Acute Myeloid Leukemia (2018) (0)
- Abstract 15887: Clonal Hematopoiesis Links Premature Menopause to Cardiovascular Disease (2020) (0)
- PPM1D Truncating Mutations Confer Chemotherapy Resistance in Hematopoietic Stem Cells, Which Is Reversible By PPM1D Inhibition (2016) (0)
- Blackfan anemia and del ( 5 q ) MDS by activating the L-leucine improves the anemia and developmental defects associated (2012) (0)
- Role of Hypomethylating Agents in the Treatment of Bone Marrow Failure (2015) (0)
- CRISPR studies identify genes preferentially essential for myeloma cells vs. other neoplasias: implications for future therapies selective against MM (2019) (0)
- Molecular markers of myeloma cell sensitivity vs. resistance to heterobifunctional degraders of oncoproteins: therapeutic implications. (2019) (0)
- Using an in-Vivo Degron-Based Approach to Interrogate Dependencies of Serially Acquired Mutations - Including DNMT3a-R882 and NPM1c - in Acute Myeloid Leukemia (2020) (0)
- Oxygen-regulated gene expression in mammalian cells (1997) (0)
- Recurrent Genetic HLA Loss in Acute Myeloid Leukemia Relapsed after Matched Unrelated Allogeneic Hematopoietic Cell Transplant (2018) (0)
- NFIB: A Gene Consistently Upregulated in MPD and Frequently Co-Amplified with JAK2V617F Augments Growth of Erythropoietin Dependent Cells (2008) (0)
- Clonal Hematopoiesis Prevalence Increases throughout Treatment of Newly Diagnosed Multiple Myeloma Patients (2021) (0)
- microarray dexamethasone: identification of dexamethasone-responsive genes by anemia recapitulates defective hematopoiesis and rescue by An RNA interference model of RPS19 deficiency in Diamond-Blackfan (2010) (0)
- Patient perspectives on testing for clonal hematopoiesis of indeterminate potential (2022) (0)
- Depletion of Jak2V617F MPN Stem Cells by IFNα in a Murine Model of Polycythemia Vera (2012) (0)
- DIPG-53. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGS) (2020) (0)
- DIPG-12. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs) (2019) (0)
- Antagonistic regulation of PMN apoptosis by G-CSF and IL-10/IL-4* (1998) (0)
- Clonal haematopoiesis and risk of chronic liver disease (2023) (0)
- Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis (2020) (0)
- A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability (2022) (0)
- Fetal Hemoglobin Silencing Correction of Sickle Cell Disease in Adult Mice by Interference with (2014) (0)
- Blood’s life history traced through genomic scars (2022) (0)
- Abstract B125: Mutant SF3B1 downregulates proteins involved in differentiation, including ABCB7 (2015) (0)
- Prevalent premalignancy. (2017) (0)
- Abstract IA13: RNA regulators and the control of self-renewal (2017) (0)
- MYBL2 Is a Candidate Tumor Suppressor Gene In MDS (2010) (0)
- Vaccination with a Personalized Dendritic Cell/AML Fusion Cell Vaccine Following Allogeneic Transplantation in a Phase 1 Clinical Trial (2020) (0)
- Ribosome Dysfunction and Ineffective Hematopoiesis. (2009) (0)
- Cooperating Effect of Rps14, Csnk1a1 and miRNA145/miRNA146a Haploinsufficiency in the Activation of the Innate Immune System in Del(5q) MDS (2015) (0)
- Lenalidomide and Dexamethasone Promote Erythropoiesis in Both Normal and RPS14 and RPS19 shRNA Infected Human CD34+ Cells: Implications for Therapy of Myelodysplastic Syndrome and Diamond-Blackfan Anemia. (2009) (0)
- Multiplex CRISPR/Cas9-Based Genome Editing of Mouse Hematopoietic Stem Cells Recapitulates Acute Erythroid Leukemia and Identifies Therapeutic Targets (2018) (0)
- Distinct Metabolic Dependency of Normal and Leukemic Cells in a Mouse Model (2011) (0)
- Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes (2021) (0)
- SNP-Array Genome Wide Association Study Meta-Analysis Identifies Innate Immune Susceptibility Loci Associated with Non-Del(5q) Myelodysplastic Syndromes Predisposition (2018) (0)
- Abstract SY13-03: Novel targeted therapies in myelodysplastic syndrome (2015) (0)
- Recombinant human erythropoietin and darbepoietin alpha exerts differential effects on non-erythroid haemopoietic cells and bone marrow microenvironment. (2012) (0)
- Bcor Mutations Cooperate with Tet2 Deficiency to Promote RAS Transformation of Mouse Hematopoietic Progenitors (2018) (0)
- Abstract 3424: Template-assisted covalent modification of DCAF16 enables BRD4 molecular glue degraders (2023) (0)
- Neutrophils Derived from Ezh2 -/- Progenitor Cells Demonstrate Aberrant Erythroid Lineage Gene Expression (2015) (0)
- Clonal Hematopoiesis: Confluence of Malignant and Nonmalignant Diseases (2022) (0)
- Germline Runx1 Mutations Induce Inflammation in Hematopoietic Stem and Progenitor Cells and Predispose to Hematologic Malignancies (2021) (0)
- Leukemic and Normal Stem Cell Transcriptional Signatures Determined by Functional Assays Are Predictive of the Overall Survival of AML Patients. (2009) (0)
- Overexpression of Ribosomal Proteins Is Insufficient for p53 Pathway Induction in Cell Lines and Primary CD34+ Cells (2012) (0)
- Selective Targeting of Leukemic Over Normal Stem Cells by the Serotonin Receptor Antagonist SB-216641 (2011) (0)
- Supplemental Information Multiplex CRISPR / Cas 9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia (2017) (0)
- Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate. (2012) (0)
- Canakinumab Effects on Erythropoiesis, Cardiovascular Risk, and Clonal Hematopoiesis: Proteogenomic Analysis of the Cantos Randomized Clinical Trial (2022) (0)
- Su.66. Memory T-Cells in Mice and Humans Share a Common Molecular Program of Differentiation Regardless of Phenotype, Lineage Or Species (2006) (0)
- Clonal Hematopoiesis at Crossroads of Aging, Cardiovascular Diseases, and Cancer: JACC Topic of the Week (2019) (0)
- Clonal Hematopoiesis Is Frequent and Associated with Inferior Survival Irrespective of Transplantation Strategy in Patients with Newly Diagnosed Multiple Myeloma (2021) (0)
- pathway activation in myeloproliferative neoplasm pathogenesis Integrated genomic analysis illustrates the central role of JAK-STAT (2014) (0)
- Clonal hematopoiesis and mosaicism revealed by a multi-tissue analysis of constitutional TP53 Status. (2022) (0)
- Testing for clonal hematopoiesis of indeterminate potential in breast cancer survivors. (2021) (0)
- 36 TERMINAL ERYTHROID DIFFERENTIATION DEFECT AND ACTIVATION OF THE INNATE IMMUNE SYSTEM IN MICE WITH RIBOSOMAL PROTEIN S14 HAPLOINSUFFICIENCY (2015) (0)
- Rapid and deep-scale ubiquitylation profiling for biology and translational research (2020) (0)
- Coordinate loss of a microRNAand protein-coding gene cooperate in the pathogenesis of 5qsyndrome (2016) (0)
- Reactivation of Silenced Human HbF In Adult Mice by Inactivation of BCL11A (2010) (0)
- 19 AN OBJECTIVE GENETIC ONTOGENY CLASSIFICATION IDENTIFIES TRUE BIOLOGICAL SECONDARY AML AMONG DE NOVO AML PATIENTS ≥60 YEARS OLD (2015) (0)
- BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS (2017) (0)
- Ccr Translations Nf1 Inactivation Revs up Ras in Adult Acute Myelogenous Leukemia (2010) (0)
- The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein (2023) (0)
- Regulation of Trib2 gene expression in normal and AML cells (2011) (0)
- 288 Point mutations in myelodysplastic syndromes: Associations with clinical features and independent predictors of overall survival (2011) (0)
- miR-126 Regulates Distinc t Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells Graphical (0)
- Abstract 669: Compound heterozygous Sf3b1-K700E mutation and Atm deletion in B cells leads to CLL in mice (2016) (0)
- Abstract 4369: Genome-wide copy number dependency analysis identifies partial copy loss of SF3B1 as a novel cancer vulnerability (2016) (0)
- In Response to Lymphohematopoietic Clones (2022) (0)
- Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins (2019) (0)
- Integrative Genomic Analysis of HIV-Specific CD8+ T Cells Reveals That PD-1 Inhibits T Cell Function by Upregulating the AP-1 Transcription Factor BATF. (2009) (0)
- P-103 Occult NRAS mutations with very low allele burden have independent prognostic significance in lower-risk myelodysplastic syndromes (2013) (0)
- 3127 – MODELING PREDISPOSED AND SPORADIC CLONAL HEMATOPOIESIS USING INDUCED PLURIPOTENT STEM CELLS (2020) (0)
- Identification of Small Molecules Selectively Targeting Leukemic Stem Cells within Their Stromal Niche (2012) (0)
- Abstract 2449: Transcriptome and whole-genome sequencing analysis of a novel murine model of chronic lymphocytic leukemia (2017) (0)
- Abstract C75: Granulin‐expressing bone marrow cells promote the outgrowth of indolent tumors (2009) (0)
- Discovery Science and Integrating Molecular Diagnosis into Clinical Practice (2012) (0)
- Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (2021) (0)
- The utility of the novel optimized HLH inflammatory (OHI) index for predicting the risk for mortality and causes of death in lymphoma. (2022) (0)
- A Proteomics Screen Identifies MDM2 Binding Partners Specific to Ribosomal Protein Haploinsufficiency (2014) (0)
- Obesity induced inflammation exacerbates clonal hematopoiesis. (2023) (0)
- Transcriptional Mapping of T Cell Memory Reveals That Chronic Viral Infection Arrests Memory Differentiation. (2005) (0)
- Predicting progression to AML (2018) (0)
- Clonal Diversity and Mutated Genes in Myelodysplastic Syndromes (2015) (0)
- Tet2 Loss Accelerates The Myeloproliferative Neoplasm (MPN) Phenotype Of Jak2V617F Knockin Mice But Is Insufficient To Cause Leukemic Transformation (2013) (0)
- Abstract 6168: Implementation and adoption of a web tool to support precision diagnostic and treatment decisions for patient with myelodysplastic syndromes (2023) (0)
- Targeting ubiquitin ligases for the treatment of hematologic malignancies (2014) (0)
- Clonal haematopoiesis and dysregulation of the immune system. (2023) (0)
- 10th Chabner Colloquium: Answering the Big Questions in Cancer Research (2019) (0)
- UbiFast, a rapid and deep-scale ubiquitylation profiling approach for biology and translational research (2019) (0)
- Abstract 3606: Lenalidomide switch control of CAR T-cell phenotype and function via degradable membrane-bound IL-7 (2022) (0)
- From Human Genetic to Mouse Model: SF3B1 Mutation and its Impact on Chronic Lymphocytic Leukemia (2016) (0)
- Congenital X-Linked Myelodysplasia with Tetraploidy Is Associated with De Novo Germline C-Terminal Mutation of SEPT6, a Septin Filament Protein (2018) (0)
- Casein Kinase 1 Alpha Maintains Normal and Leukemic Stem Cells by Regulating p53 Activity (2012) (0)
- Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders (2023) (0)
- Comprar Myelodysplastic Syndromes, An Issue of Hematology/Oncology Clinics of North America | Benjamin L. Ebert | 9781437722031 | Saunders (2010) (0)
- Msi2 Directly Regulates The TGF-β Signaling Pathway and Myeloid Lineage Bias In Hematopoietic Stem Cells (2013) (0)
- Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant (2020) (0)
- P-083 5q-syndrome or diamond blackfan anemia: The perplexing diagnostic puzzle of red cell aplasia (2013) (0)
- A Novel Inflammatory Index Is Sufficient to Identify Hemophagocytic Lymphohistiocytosis in Adult Patients with Hematologic Malignancies (2020) (0)
- Cooperation of KITD816V and TET2 loss of function in the pathogenesis of systemic mastocytosis and associated hematological malignancies (2013) (0)
- Integrative Analysis of Genomic Aberration and Gene Expression Suggests That MPD with Loss of Heterozygosity or Gain of Chromosome 9 Represents a Distinct Entity (2008) (0)
- Supplementary Material 8 (2013) (0)
- Abstract PL02-03: The zinc-finger degrome (2019) (0)
- Incidence, Clinical Associations, and Co-Mutation Patterns of UBA1 Mutations in MDS (2022) (0)
- Ontogeny-Specific Patterns of Genetic Alterations in Acute Myeloid Leukemia (2014) (0)
- Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5 q-syndrome RUNNING TITLE : COOPERATIVE LOSS OF MIR-145 AND RPS 14 IN 5 Q-MDS (2011) (0)
- All Memory Lymphocytes Share a Common Differentiation Program. (2006) (0)
- Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c) (2022) (0)
- RED CELLS , IRON , AND ERYTHROPOIESIS Diminutive somatic deletions in the 5 q region lead to a phenotype atypical of classical 5 q 2 syndrome (2013) (0)
- Board Review in Hematology (2012) (0)
- Abstract #5666: Systemic instigation of stromal desmoplasia and indolent tumor outgrowth via activation of granulin-expressing Sca1+/cKit- bone marrow cells (2009) (0)
- Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells (2012) (0)
- CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias (2018) (0)
- A molecular glue approach to control the half-life of CRISPR-based technologies (2023) (0)
- Genetic modification of inflammation and clonal hematopoiesis-associated coronary artery disease (2022) (0)
- Characterizing the Disease-Initiating Cell Population In a Murine Model of Jak2V617F+ Myeloproliferative Neoplasm (2010) (0)
- Expression of Proliferation Related Genes in Myelodysplastic Syndromes (MDS) and Secondary Acute Myeloid Leukemia (AML) Patients with Resistance to Low Dose Vidaza and Thalidomide. (2006) (0)
- STATistical power of clonal analysis: differential STAT1 pathway activation downstream of the JAK2V617F mutation. (2010) (0)
- Exploiting the Zinc Finger Degrome Targeted By Lenalidomide to Engineer Reversible Off-Switch Degradable Chimeric Antigen Receptors (2019) (0)
- Critical Role Of Casein Kinase (Ck)1α Heterozygote Gene Inactivation In The Clonal Advantage Of Hematopoietic Stem Cells In Del(5q) MDS (2013) (0)
- Genomic Microarray Alterations Add Prognostic Power to the IPSS-R in MDS with Normal Karyotype (2014) (0)
- Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer (2020) (0)
- Transcriptional mapping of the anti-viral T cell response shows that impaired memory differentiation causes T cell dysfunction (2006) (0)
- Whole exome sequencing of a breast tumor in a patient with Diamond Blackfan anemia. (2021) (0)
- PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation (2022) (0)
- Moving Beyond Elementary Mathematics in Acute Myeloid Leukemia (2012) (0)
- Clonal hematopoiesis transcending species barriers. (2022) (0)
- Specific Clonal Mutations Are Predictive of Therapy-Related Myeloid Neoplasms (tMN) after Autologous Peripheral Blood Stem Cell Transplantation (aPBSCT) for Lymphoma (2022) (0)
- RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program (2016) (0)
- Genome-Wide Analysis of a Novel Murine Model of Chronic Lymphocytic Leukemia (2016) (0)
- A Novel Conditional Knockout of the Diamond Blackfan Anemia Gene Rpl11 Shows Failure of Erythropoiesis, a Marked Increase in BFU-E Progenitors By Phenotype That Proliferate Poorly in Culture, and Activation of p53 Target Genes (2015) (0)
- Calmodulin Inhibition Rescues the Effects of Ribosomal Protein Deficiency in in Vitro and In Vivo Diamond Blackfan Anemia Models (2015) (0)
- Induction of Fetal Hemoglobin by Inactivation of HDAC1 or HDAC2 without Altering Cellular Proliferation (2011) (0)
- Leukemia and Heart Disease (2022) (0)
- Clonal Hematopoiesis and Risk of Incident Lung Cancer (2022) (0)
- A Cryptic Intronic GATA1 Splicing Mutation Provides Insights Into Human Hematopoietic Differentiation (2018) (0)
- The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K (2020) (0)
- Abstract 2570: Identification of genetic polymorphisms associated with myelodysplastic syndromes by genome-wide association study (2016) (0)
- Chapter 60 – Myelodysplastic Syndromes (2018) (0)
- UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability (2022) (0)
- Normalized expression of each gene in the response signature is shown in the heat map (2011) (0)
- CRISPR off-target sequencing analysis (2017) (0)
- Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level (2019) (0)
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