Benno Müller‐hill

Benno Müller‐hill's AcademicInfluence.com Rankings

Benno Müller‐hill

Biology

#9079

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#12238

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Biochemistry

#1358

World Rank

#1479

Historical Rank

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Biology

Benno Müller‐hill's Degrees

PhD Biochemistry University of Cologne

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Benno Müller‐hill's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor (1987) (3948)
ISOLATION OF THE LAC REPRESSOR (1966) (555)
Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. (1977) (515)
Easy identification of cDNA clones. (1983) (465)
The three operators of the lac operon cooperate in repression. (1990) (452)
Sequence of the lacZ gene of Escherichia coli. (1983) (397)
Sequence of the lactose permease gene (1980) (368)
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. (1988) (364)
Mutants that make more lac repressor. (1968) (318)
lac repressor forms loops with linear DNA carrying two suitably spaced lac operators. (1987) (292)
The lac Operon: A Short History of a Genetic Paradigm (1996) (258)
The lac operator is DNA. (1967) (238)
Quality and position of the three lac operators of E. coli define efficiency of repression. (1994) (225)
Repression oflacPromoter as a Function of Distance, Phase and Quality of an AuxiliarylacOperator (1996) (220)
Genetic Studies of Lac Repressor: 4000 Single Amino Acid Substitutions and Analysis of the Resulting Phenotypes on the Basis of the Protein Structure (1996) (201)
pUR222, a vector for cloning and rapid chemical sequencing of DNA. (1981) (201)
Molecular biology of Alzheimer's disease. (1989) (197)
Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator. (1996) (182)
How lac Repressor Binds to DNA (1972) (176)
Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain. (1990) (175)
Lac repressor can be fused to β-galactosidase (1974) (164)
Lac repressor and lac operator. (1975) (141)
Murderous Science: Elimination by Scientific Selection of Jews, Gypsies, and Others, Germany 1933-1945 (1988) (138)
Four dimers of λ repressor bound to two suitably spaced pairs of λ operators form octamers and DNA loops over large distances (1999) (133)
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. (1989) (121)
Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. (1993) (116)
The interaction of the recognition helix of lac repressor with lac operator. (1987) (116)
DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. (1988) (113)
Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. (1984) (110)
Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat (1984) (91)
Mutant lac repressors with new specificities hint at rules for protein‐‐DNA recognition. (1990) (90)
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli. (1982) (79)
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4‐helical bundle. (1993) (76)
Nucleotide sequences of the gal E gene and the gal T gene of E. coli. (1986) (73)
The function of auxiliary operators (1998) (70)
How AraC interacts specifically with its target DNAs. (1996) (69)
How Lac repressor finds lac operator in vitro. (1992) (69)
Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF‐1 that are involved in specific DNA binding. (1993) (67)
Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. (1986) (66)
How Trp repressor binds to its operator. (1990) (66)
lac repressor forms stable loops in vitro with supercoiled wild-type lac DNA containing all three natural lac operators. (1990) (64)
The 11‐1 gene of Plasmodium falciparum codes for distinct fast evolving repeats. (1988) (61)
High local protein concentrations at promoters: strategies in prokaryotic and eukaryotic cells. (2001) (59)
Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. (1999) (59)
lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges. (1989) (59)
On the conservation of protein sequences in evolution. (2000) (57)
Sequence homology between Lac and Gal repressors and three sugar-binding periplasmic proteins (1983) (55)
Induction of the lac promoter in the absence of DNA loops and the stoichiometry of induction (2006) (53)
Isolation, genetic analysis, and characterization of Escherichia coli mutants with defects in the lacY gene (1977) (52)
Quality and efficiency of basic research in molecular biology: a bibliometric analysis of thirteen excellent research institutes (1995) (52)
Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences. (1988) (50)
Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold. (1987) (50)
Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat. (1991) (49)
Genetic analysis of transpositions in the lac region of Escherichia coli. (1980) (48)
Heroes and villains (1988) (48)
Investigation of structure and function of lactose permease of Escherichia coli. (1980) (45)
[39] Lac Repressor from Escherichia coli (1971) (45)
Replacement of invariant bZip residues within the basic region of the yeast transcriptional activator GCN4 can change its DNA binding specificity. (1994) (44)
Immunoenzymatic detection of expressed gene fragments cloned in the lac Z gene of E. coli. (1982) (43)
Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. (1977) (43)
Mutations in the lacY gene of Escherichia coli define functional organization of lactose permease. (1981) (42)
beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. (1978) (42)
Some repressors of bacterial transcription. (1998) (42)
Dimerisation mutants of Lac repressor. I. A monomeric mutant, L251A, that binds Lac operator DNA as a dimer. (1999) (40)
The sequence of the two extra exons in rat preA4. (1989) (39)
High local concentration: a fundamental strategy of life. (2010) (38)
Cloning and expression of genomic DNA sequences coding for putative erythrocyte membrane-associated antigens of Plasmodium falciparum. (1991) (37)
The fraud of Abderhalden's enzymes (1998) (34)
Exon cloning: immunoenzymatic identification of exons of the chicken lysozyme gene. (1982) (32)
Strengthening the dimerisation interface of Lac repressor increases its thermostability by 40 deg. C. (2000) (30)
Cloning and characterization of the MboII restriction-modification system. (1991) (29)
Does the lactose carrier of Escherichia coli function as a monomer? (1983) (27)
Suppressible regulator constitutive mutants of the lactose system in Escherichia coli. (1966) (27)
Dimeric lac repressors exhibit phase-dependent co-operativity. (1998) (27)
In vitro phagocytosis inhibition assay for the screening of potential candidate antigens for sub-unit vaccines against the asexual blood stage of Plasmodium falciparum. (1993) (26)
Amplification of the lactose carrier protein in Escherichia coli using a plasmid vector (1978) (26)
Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV. (1998) (26)
The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac operator binding. (1991) (25)
The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid. (1993) (25)
A synthetic operon containing 14 bovine pancreatic trypsin inhibitor genes is expressed in E. coli. (1986) (25)
Lactose permease of Escherichia coli: properties of mutants defective in substrate translocation. (1987) (24)
Identification of cDNAs encoding two novel rat pancreatic serine proteases. (1992) (24)
In vitro phagocytosis inhibition assay for the screening of potential candidate antigens for sub-unit vaccines against the asexual blood stage of Plasmodium falciparum (1993) (23)
A comparison of the different DNA binding specificities of the bZip proteins C/EBP and GCN4. (1995) (23)
The side-chain of the amino acid residue in position 110 of the Lac repressor influences its allosteric equilibrium. (1996) (23)
Operator search by mutant Lac repressors. (1998) (23)
Identification of Internal Residues of Lactose Permease of Escherichia Coli by Radiolabel Sequencing of Peptide Mixtures (1982) (22)
Dimerisation mutants of Lac repressor. II. A single amino acid substitution, D278L, changes the specificity of dimerisation. (2000) (21)
Inhibition of the synthesis of β-galactosidase in Escherichia coli by 2-nitrophenyl-β-d-fucoside (1966) (21)
F'-coded, temperature-sensitive lambda cI857 repressor gene for easy construction and regulation of lambda promoter-dependent expression systems (1985) (21)
The shadow of genetic injustice (1993) (20)
The polymorphic 11.1 locus of Plasmodium falciparum. (1987) (20)
Der lac‐Repressor (1971) (19)
Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain‐specific trypsinogen IV (1998) (19)
A positive selection vector for cloning of long polymerase chain reaction fragments based on a lethal mutant of the crp gene of Escherichia coli. (1998) (18)
A model of the lac repressor-operator complex based on physical and genetic data. (1991) (17)
A versatile phage lambda expression vector system for cloning in Escherichia coli. (1989) (15)
Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions. (1994) (15)
Fused lacZ genes code for di‐, tri‐ and tetra‐beta‐galactosidase in Escherichia coli. (1985) (15)
Lac repressor can be fused to beta-galactosidase. (1974) (15)
Seeds of the past (1990) (14)
The sequence of a third member of the heat shock protein family in Plasmodium falciparum. (1989) (14)
Characterization of beta-galactosidase--lactose-permease chimaeras of Escherichia coli. (1983) (14)
The blood from Auschwitz and the silence of the scholars. (1999) (13)
Lac repressor with the helix‐turn‐helix motif of lambda cro binds to lac operator. (1992) (12)
Linker mutagenesis in the lacZ gene of Escherichia coli yields variants of active beta-galactosidase. (1991) (12)
Lambda cI repressor mutants altered in transcriptional activation. (1994) (12)
Similarities between Lac Repressor and Lambda Repressor (1977) (11)
Characterisation of P. falciparum antigenic determinants isolated from a genomic expression library by differential antibody screening. (1985) (11)
Co‐operative binding of two Trp repressor dimers to α‐ or β‐centred trp operators (1996) (10)
The Fate of Industrial Carbon Dioxide (2004) (10)
Structure and function of a thymic peptide is mimicked by Plasmodium falciparum peptides. (1988) (10)
gal4 transcription activator protein of yeast can function as a repressor in Escherichia coli. (1987) (10)
Mutant bZip‐DNA complexes with four quasi‐identical protein‐DNA interfaces. (1996) (10)
What is life? The paradigm of DNA and protein cooperation at high local concentrations (2006) (9)
DNA recognition and the code (1994) (9)
lacZ--Y+ fusions in Escherichia coli. DNA sequencing reveals the eight N-terminal residues of lac permease as non-essential. (1983) (8)
Genetics of susceptibility to tuberculosis: Mengele's experiments in Auschwitz (2001) (8)
Mutant lac Repressors of Escherichia coli with Altered Deoxyribonucleic Acid-Binding Properties (1975) (8)
Macromolecular interactions: tracing the roots (2001) (8)
Insertion of d(pCpG)n.d(pCpG)n into the lacZ gene of Escherichia coli inhibits expression of beta-galactosidase in vivo. (1988) (8)
Rules for Protein DNA Recognition for a Family of Helix-Turn-Helix Proteins (1991) (7)
GENETICS AFTER AUSCHWITZ (1987) (7)
A Lethal Mutant of the Catabolite Gene Activator Protein CAP of Escherichia coli (1997) (7)
A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose (2004) (6)
Genetics after Auschwitz. (1987) (6)
From Daedalus to Mengele: the dark side of human genetics. (1989) (6)
Single exchanges of amino acids in the basic region change the specificity of N-Myc. (1993) (6)
SCIENCE, TRUTH AND OTHER VALUES* (1993) (5)
A basic tail increases repression by dimeric lac repressor. (1995) (5)
Inhuman Research: Medical Experiments in German Concentration Camps (review) (2009) (5)
Chapter V: The Lactose Repressor (1970) (4)
Human behavioural genetics--past and future. (2002) (4)
Chapter 7 A Study of Mutants of the Lactose Transport System of Escherichia coli (1985) (4)
Observations on the kinetics of the induction of β-galactosidase in Escherichia coli (1965) (4)
Single-Stranded Filamentous DNA Phage as a Carrier for in vitro Recombined DNA (1978) (4)
Induction of Transcription (2013) (3)
The possible roles of residues 79 and 80 of the Trp repressor from Escherichia coli K-12 in trp operator recognition (1995) (3)
THE IDEA OF THE FINAL SOLUTION AND THE ROLE OF EXPERTS (2002) (3)
Prokaryotic control of transcription: How and why does it differ from eukaryotic control? (1995) (2)
72 residues of gal repressor fused to beta‐galactosidase repress the gal operon of E. coli. (1983) (2)
Experiments with gene fusions: edited by T. J. Silhavy, M. L. Berman and L. W. Enquist, Cold Spring Harbor Laboratory, 1984. US$51.50 ($62.40 elsewhere) (xv + 303 pages) ISBN 0 87969 163 8 (1985) (2)
Selective Perception: The Letters of Adolf Butenandt Nobel Prize Winner and President of The Max-Planck-Society* (2003) (2)
Bacterial Transcription Regulation (2004) (2)
Truth, justice, and genetics. (2000) (2)
The isolation of the lac repressor. (1990) (2)
The different faces of science: is genetics a social construct? (1998) (2)
European research institutes. (1992) (1)
Chapter 9 - My Happy Days with Lac Repressor – in a Dark World (2003) (1)
The repeat of the same. (1989) (1)
From eugenics to genocide (1988) (1)
Lac repressor. (1971) (1)
Lessons from a dark and distant past (2006) (1)
Mutants in position 69 of the Trp repressor of (1996) (1)
[Remembrance and denial. A critical look into correspondence of Adolf Butenandt, MPG president 1960-1972]. (2002) (1)
WHAT CAN BE LEARNED FROM THE GENETIC ANALYSIS OF LAC REPRESSOR (1979) (1)
Life's dead letter (1997) (1)
Reflections on the use of interviews in the history of science: who will write the history of science? (2001) (1)
Towards a linguistics of DNA and protein. (1999) (1)
Hidden history (2004) (1)
Mutations inthelacYgeneofEscherichia coli define functional organization oflactose permease (1981) (1)
DNA for the People? (2003) (1)
Mutants with substitutions for Glu171 in the catabolite activator protein (CAP) of Escherichia coli activate transcription from the lac promoter (1993) (1)
Attempts to Transfer Lab Structure and Scientific Habits from Harvard to Cologne (2007) (1)
The Origins of Nazi Genocide: From Euthanasia to the Final Solution (1995) (1)
Mutants in position 69 of the Trp repressor ofEscherichia coli K12 with altered DNA-binding specificity (1996) (1)
DNA recognition by bhlh proteins. A model of the DNA binding domain of nmyc (1994) (0)
λImmunity phase shift in a λN−-lacZ+ fusion (1981) (0)
Mum's a test-tube (1996) (0)
BOOK REVIEWS: ANNOUNCEMENT (1992) (0)
Part 1: A Short History of the lac System from its Beginning to 1978 (1996) (0)
Science, a social product? (2002) (0)
A poisonous present (2005) (0)
Part 2: Misinterpretation (1996) (0)
The operon: edited by J. H. Miller and W. S. Reznikoff, Cold Spring Harbor Laboratory, New York, 1978. $42.00 (vii + 449 pages) ISBN 0 87969 124 7 (1979) (0)
On science and scientists: I Wish I’d Made You Angry Earlier. Essays on Science, Scientists and Humanity, by Max F. Perutz (1999) (0)
[How does the lac repressor recognize the lac operator?]. (1972) (0)
From genes to biochemistry (2003) (0)
Comments on: Biosciences in totalitarian regimes: the lessons to be learned from Nazy Germany (1993) (0)
Buchbesprechung: Operators and Promoters. The Story of Molecular Biology and its Creators. Herausgegeben von Harrison Echols und Carol A. Gross (2002) (0)
How Trp repressor binds to its operator. (1990) (0)
Crimes in the name of research (2008) (0)
Die heile Welt der Angewandten Chemie: Guardians of Science. Fairness and Reliability of Peer Reviews. Von H.‐D. Daniel. VCH, Weinheim, 1993. 118 S., 9 Abb., 27 Tab., geb. 78,‐DM. ISBN 3‐527‐29041‐9. (1994) (0)
[100 years of Escherichia coli]. (1986) (0)
Eugenics, a good idea? (2002) (0)
Direct cloning and identification of exon structures from genomic DNA (1983) (0)
Synthetic multifunctional proteins (1977) (0)
Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside. (1966) (0)
Book Review: Operators and Promoters. The story of Molecular Biology and its Creators. By Harrison Echols and Carol A. Gross (2002) (0)
Cologne fall meeting: Medical science without compassion — past and present (1990) (0)
Separation of subunits of the linkage factor 1 of chloroplasts (CF 1 ) and their immunological characterization (1972) (0)
Isopropyl‐1‐Thio‐β‐D‐Galactopyranoside (2002) (0)
The memoirs of an activist (2002) (0)
Funding of molecular biology. (1991) (0)
The cultures of genetics (1997) (0)
The relaxed murderers (1986) (0)
Part 3: The lac Operon, a Paradigm of Beauty and Efficiency (1996) (0)
Genmanipulation und Gentherapie: by W. Klingmüller, published by Springer-Verlag, Berlin, Heidelberg, New York, 1976. DM38.-(approx. $15.60) (1977) (0)
Chapter 10 – A Dark Side of Science in Difficult Times (2003) (0)
“Cold-Sensitive” Mutants of the Lac Repressor (2006) (0)
Molecules comprising at least one peptide sequence bearing an epitope characteristic of a protein produced by cells infected with malaria parasites and compositions containing (1984) (0)

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