Bernard Roizman | Academic Influence

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Bernard Roizman

Biology

#781

World Rank

#1352

Historical Rank

#418

USA Rank

Virology

#11

World Rank

#12

Historical Rank

#4

USA Rank

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Biology

Bernard Roizman's Degrees

PhD Virology University of Chicago
Bachelors Biology University of Chicago

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Why Is Bernard Roizman Influential?

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According to Wikipedia, Bernard Roizman is an American scientist born in Romania. He is the Joseph Regenstein Distinguished Service Professor of Virology in the Departments of Microbiology and Molecular Genetics and Cell Biology at the University of Chicago.

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Bernard Roizman's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins (1974) (1451)
Herpes simplex viruses. (1998) (1001)
The order Herpesvirales (2008) (925)
Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. (1968) (850)
Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture. (1990) (762)
Herpes simplex virus infections (2001) (743)
The γ134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase (1997) (696)
Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. (1975) (598)
Proteins Specified by Herpes Simplex Virus V. Purification and Structural Proteins of the Herpesvirion (1972) (574)
Proteins Specified by Herpes Simplex Virus XII. The Virion Polypeptides of Type 1 Strains (1974) (516)
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (505)
An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer (2008) (464)
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes (1983) (425)
The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. (1992) (414)
Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). I. Isolation, properties and characterization. (1957) (402)
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. (1997) (360)
Proteins Specified by Herpes Simplex Virus VIII. Characterization and Composition of Multiple Capsid Forms of Subtypes 1 and 2 (1972) (348)
Size, Composition, and Structure of the Deoxyribonucleic Acid of Herpes Simplex Virus Subtypes 1 and 2 (1971) (344)
Infection with herpes-simplex viruses 1 and 2. II. (1973) (342)
Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters (1981) (339)
A generalized technique for deletion of specific genes in large genomes: a gene 22 of herpes simplex virus 1 is not essential for growth (1981) (338)
Herpesviridae. Definition, provisional nomenclature and taxonomy (1981) (333)
Infectious agents and cancer: criteria for a causal relation. (2004) (333)
An inquiry into the mechanisms of herpes simplex virus latency. (1987) (330)
The structure and isomerization of herpes simplex virus genomes (1979) (330)
Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components. (1975) (328)
The Human Herpesviruses (1993) (328)
Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants (1978) (324)
Proteins Specified by Herpes Simplex Virus XI. Identification and Relative Molar Rates of Synthesis of Structural and Nonstructural Herpes Virus Polypeptides in the Infected Cell (1973) (324)
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1. (1995) (310)
Molecular Genetics of Herpes Simplex Virus II. Mapping of the Major Viral Glycoproteins and of the Genetic Loci Specifying the Social Behavior of Infected Cells (1979) (310)
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. (1997) (308)
STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. (2004) (283)
Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. (1998) (272)
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes (1982) (269)
Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3 (1997) (266)
Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides (1981) (262)
Anatomy of herpes simplex virus DNA. II. Size, composition, and arrangement of inverted terminal repetitions (1975) (258)
Molecular genetics of herpes simplex virus. VIII. further characterization of a temperature-sensitive mutant defective in release of viral DNA and in other stages of the viral reproductive cycle (1983) (256)
Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice (1985) (251)
The Replication of Herpesviruses (1974) (247)
In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020: construction and evaluation in rodents. (1988) (246)
Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA (1980) (245)
Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins (1998) (239)
Regulation of herpesvirus macromolecular synthesis. V. Properties of alpha polypeptides made in HSV-1 and HSV-2 infected cells. (1977) (236)
Role of ICP0 in the Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1 (2004) (234)
The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate (1991) (229)
Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. (1978) (228)
Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells. (1993) (217)
Development of a High-Throughput Quantitative Assay for Detecting Herpes Simplex Virus DNA in Clinical Samples (1999) (215)
The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors. (1996) (214)
Entry of herpes simplex virus 1 in BJ cells that constitutively express viral glycoprotein D is by endocytosis and results in degradation of the virus (1988) (214)
Anatomy of the herpes simplex virus 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody-resistant mutants (1985) (214)
The isolation and properties of a variant of Herpes simplex producing multinucleated giant cells in monolayer cultures in the presence of antibody. (1959) (214)
Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. (1988) (213)
A DNA fragment of Herpes simplex 2 and its transcription in human cervical cancer tissue. (1972) (210)
Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma. (1995) (208)
Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins. (1987) (206)
Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture (1987) (206)
The Family Herpesviridae: General Description, Taxonomy, and Classification (1982) (204)
Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. (2005) (204)
Promyelocytic Leukemia Protein Mediates Interferon-Based Anti-Herpes Simplex Virus 1 Effects (2003) (201)
Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery (1997) (199)
Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage. (1994) (198)
Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models. (1993) (195)
Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19 (2020) (190)
Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodies (1984) (187)
The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia. (1996) (186)
Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions (1980) (184)
Dna restriction-enzyme analysis of herpes simplex virus isolates obtained from patients with encephalitis. (1982) (183)
The γ134.5 Protein of Herpes Simplex Virus 1 Has the Structural and Functional Attributes of a Protein Phosphatase 1 Regulatory Subunit and Is Present in a High Molecular Weight Complex with the Enzyme in Infected Cells* (1998) (183)
The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene (1991) (180)
The Herpes Simplex Virus 1 UL34 Protein Interacts with a Cytoplasmic Dynein Intermediate Chain and Targets Nuclear Membrane (2000) (180)
The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein alpha 22. (1992) (179)
A noninverting genome of a viable herpes simplex virus 1: presence of head-to-tail linkages in packaged genomes and requirements for circularization after infection (1985) (177)
The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture (1991) (177)
An inquiry into the molecular basis of HSV latency and reactivation. (2013) (175)
Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST–REST complex (2007) (174)
The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress (1991) (173)
The Herpes Simplex Virus US11 Protein Effectively Compensates for the γ134.5 Gene if Present before Activation of Protein Kinase R by Precluding Its Phosphorylation and That of the α Subunit of Eukaryotic Translation Initiation Factor 2 (1998) (172)
Demonstration of exogenous genital reinfection with herpes simplex virus type 2 by restriction endonuclease fingerprinting of viral DNA. (1979) (170)
Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors. (1997) (169)
Clustering of genes dispensable for growth in culture in the S component of the HSV-1 genome. (1987) (169)
Proteins Specified by Herpes Simplex Virus VI. Viral Proteins in the Plasma Membrane (1972) (169)
Anatomy of herpes simplex virus DNA: strain differences and heterogeneity in the locations of restriction endonuclease cleavage sites. (1975) (167)
Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. (2004) (167)
The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors. (1996) (165)
Genetic Relatedness of Type 1 and Type 2 Herpes Simplex Viruses (1972) (162)
Generation of an inverting herpes simplex virus 1 mutant lacking the L-S junction a sequences, an origin of DNA synthesis, and several genes including those specifying glycoprotein E and the alpha 47 gene (1986) (162)
Differentiation of respiratory and abortigenic isolates of equine herpesvirus 1 by restriction endonucleases. (1981) (162)
Anatomy of Herpes Simplex Virus DNA. IX. Apparent Exclusion of Some Parental DNA Arrangements in the Generation of Intertypic (HSV-1 × HSV-2) Recombinants (1977) (161)
Compartmentalization of spermine and spermidine in the herpes simplex virion. (1971) (159)
Glycoprotein D or J Delivered in transBlocks Apoptosis in SK-N-SH Cells Induced by a Herpes Simplex Virus 1 Mutant Lacking Intact Genes Expressing Both Glycoproteins (2000) (159)
Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments. (1980) (158)
Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors (1998) (157)
The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells (1996) (155)
The UL11 gene of herpes simplex virus 1 encodes a function that facilitates nucleocapsid envelopment and egress from cells (1992) (154)
Anatomy of herpes simplex virus DNA. III. Characterization of defective DNA molecules and biological properties of virus populations containing them (1975) (154)
In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020. II. Studies in immunocompetent and immunosuppressed owl monkeys (Aotus trivirgatus). (1990) (152)
Proteins Specified by Herpes Simplex Virus X. Staining and Radiolabeling Properties of B Capsid and Virion Proteins in Polyacrylamide Gels (1974) (147)
Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated (1979) (147)
The promoter, transcriptional unit, and coding sequence of herpes simplex virus 1 family 35 proteins are contained within and in frame with the UL26 open reading frame (1991) (147)
Infection with herpes-simplex viruses 1 and 2. 3. (1973) (146)
Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes. (1987) (146)
Molecular Pathways: Interferon/Stat1 Pathway: Role in the Tumor Resistance to Genotoxic Stress and Aggressive Growth (2012) (145)
Anatomy of Herpes Simplex Virus DNA. VIII. Properties of the Replicating DNA (1977) (144)
Ocular disease pattern induced by herpes simplex virus is genetically determined by a specific region of viral DNA (1982) (144)
The Second-Site Mutation in the Herpes Simplex Virus Recombinants Lacking the γ134.5 Genes Precludes Shutoff of Protein Synthesis by Blocking the Phosphorylation of eIF-2α (1998) (143)
Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene (1997) (143)
The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits (1992) (143)
THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. II. THE RELATION BETWEEN PROTEIN SYNTHESIS AND THE DUPLICATION OF VIRAL DNA IN INFECTED HEP-2 CELLS. (1964) (143)
Polysomes and Protein Synthesis in Cells Infected with a DNA Virus (1966) (142)
Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs (2014) (142)
Site-specific inversion sequence of the herpes simplex virus genome: domain and structural features. (1981) (142)
The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity (2001) (142)
The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. (1999) (140)
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a (2003) (139)
The UL10 gene of herpes simplex virus 1 encodes a novel viral glycoprotein, gM, which is present in the virion and in the plasma membrane of infected cells (1993) (138)
The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component (1986) (137)
The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+ (1990) (136)
The null mutant of the U(L)31 gene of herpes simplex virus 1: construction and phenotype in infected cells (1997) (134)
ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. (2006) (134)
Assemblons: nuclear structures defined by aggregation of immature capsids and some tegument proteins of herpes simplex virus 1 (1996) (132)
Herpes simplex genes: the blueprint of a successful human pathogen. (1994) (132)
Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1. (1993) (129)
Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis (1995) (129)
Herpes Simplex Virus 1 Gene Products Occlude the Interferon Signaling Pathway at Multiple Sites (2004) (128)
Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes. (1986) (128)
Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion (1980) (127)
Proteolytic Cleavage of VP1-2 Is Required for Release of Herpes Simplex Virus 1 DNA into the Nucleus (2008) (127)
Identification of a herpes simplex virus 1 glycoprotein gene within a gene cluster dispensable for growth in cell culture. (1987) (127)
Genetic engineering of novel genomes of large DNA viruses. (1985) (124)
TRANSMISSION OF HERPES-SIMPLEX VIRUS TYPE 1 IN A NURSERY FOR THE NEWBORN IDENTIFICATION OF VIRAL ISOLATES BY D.N.A. "FINGERPRINTING" (1978) (122)
Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. (2007) (121)
RNA synthesis in cells infected with herpes simplex virus. X. Properties of viral symmetric transcripts and of double-stranded RNA prepared from them (1975) (118)
Concerning the egress of herpes simplex virus from infected cells: electron and light microscope observations. (1969) (118)
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters. (1981) (116)
The US3 Protein Kinase Blocks Apoptosis Induced by the d120 Mutant of Herpes Simplex Virus 1 at a Premitochondrial Stage (2001) (116)
Identification and preliminary mapping with monoclonal antibodies of a herpes simplex virus 2 glycoprotein lacking a known type 1 counterpart. (1984) (116)
Separation of sequences defining basal expression from those conferring alpha gene recognition within the regulatory domains of herpes simplex virus 1 alpha genes. (1984) (115)
HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs (2011) (115)
Application of Denatured, Electrophoretically Separated, and Immobilized Lysates of Herpes Simplex Virus-Infected Cells for Detection of Monoclonal Antibodies and for Studies of the Properties of Viral Proteins (1983) (114)
Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model. (2005) (113)
The disaggregation of host polyribosomes in productive and abortive infection with herpes simplex virus. (1967) (110)
Origin of unenveloped capsids in the cytoplasm of cells infected with herpes simplex virus 1 (1991) (110)
Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection (2002) (110)
Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes (2002) (110)
Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes. (1985) (110)
Role of ICP 0 in the Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1 (2004) (109)
Similarities and Differences in the Development of Laboratory Strains and Freshly Isolated Strains of Herpes Simplex Virus in HEp-2 Cells: Electron Microscopy (1969) (109)
Macromolecular Synthesis in Cells infected with Herpes Simplex Virus (1965) (108)
Herpesvirus-dependent amplification and inversion of cell-associated viral thymidine kinase gene flanked by viral a sequences and linked to an origin of viral DNA replication. (1982) (107)
The Disappearance of Cyclins A and B and the Increase in Activity of the G2/M-Phase Cellular Kinase cdc2 in Herpes Simplex Virus 1-Infected Cells Require Expression of the α22/US1.5 and UL13 Viral Genes (2000) (107)
Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1 (1993) (107)
Expression of a herpes simplex virus 1 open reading frame antisense to the gamma(1)34.5 gene and transcribed by an RNA 3' coterminal with the unspliced latency-associated transcript (1994) (103)
Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase (1997) (103)
Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. (1999) (102)
RNAs Extracted from Herpes Simplex Virus 1 Virions: Apparent Selectivity of Viral but Not Cellular RNAs Packaged in Virions (2001) (102)
Epstein-Barr virus genome may encode a protein showing significant amino acid and predicted secondary structure homology with glycoprotein B of herpes simplex virus 1 (1985) (102)
Requirements for the Nuclear-Cytoplasmic Translocation of Infected-Cell Protein 0 of Herpes Simplex Virus 1 (2001) (102)
Characterization of the protease and other products of amino-terminus-proximal cleavage of the herpes simplex virus 1 UL26 protein (1993) (101)
The product of the UL31 gene of herpes simplex virus 1 is a nuclear phosphoprotein which partitions with the nuclear matrix (1993) (100)
Herpes Simplex Virus 1 Blocks Caspase-3-Independent and Caspase-Dependent Pathways to Cell Death (1999) (100)
Cell Surface Major Histocompatibility Complex Class II Proteins Are Regulated by the Products of the γ134.5 and UL41 Genes of Herpes Simplex Virus 1 (2002) (100)
Engineered herpes simplex virus 1 is dependent on IL13Rα2 receptor for cell entry and independent of glycoprotein D receptor interaction (2002) (100)
Construction and properties of a recombinant herpes simplex virus 1 lacking both S-component origins of DNA synthesis (1993) (99)
Infection with herpes-simplex viruses 1 and 2. 1. (1973) (99)
Molecular genetics of herpes simplex virus: demonstration of regions of obligatory and nonobligatory identity within diploid regions of the genome by sequence replacement and insertion. (1978) (99)
The DNA-binding properties of the major regulatory protein alpha 4 of herpes simplex viruses. (1988) (98)
Infection with herpes-simplex viruses 1 and 2 (second of three parts). (1973) (98)
Proteins specified by herpes simplex virus. 3. Viruses differing in their effects on the social behavior of infected cells specify different membrane glycoproteins. (1970) (97)
Preparation of herpes simplex virus of high titer (1968) (96)
The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific. (2004) (96)
Ionizing radiation improves survival in mice bearing intracranial high-grade gliomas injected with genetically modified herpes simplex virus. (1999) (96)
Herpes Simplex Virus 1 Gene Expression Is Accelerated by Inhibitors of Histone Deacetylases in Rabbit Skin Cells Infected with a Mutant Carrying a cDNA Copy of the Infected-Cell Protein No. 0 (2003) (96)
THE STRUCTURE OF HERPES SIMPLEX VIRUS DNA AND ITS APPLICATION TO MOLECULAR EPIDEMIOLOGY * (1980) (95)
The herpes simplex virus 1 UL11 proteins are associated with cytoplasmic and nuclear membranes and with nuclear bodies of infected cells (1995) (95)
Acyclovir Is Phosphorylated by the Human Cytomegalovirus UL97 Protein (1999) (94)
An amino acid sequence shared by the herpes simplex virus 1 alpha regulatory proteins 0, 4, 22, and 27 predicts the nucleotidylylation of the UL21, UL31, UL47, and UL49 gene products. (1994) (94)
The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene (2002) (94)
Infection of polarized MDCK cells with herpes simplex virus 1: two asymmetrically distributed cell receptors interact with different viral proteins. (1991) (94)
The promoter and transcriptional unit of a novel herpes simplex virus 1 alpha gene are contained in, and encode a protein in frame with, the open reading frame of the alpha 22 gene (1996) (93)
HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation (2014) (93)
Glycoprotein D of herpes simplex virus encodes a domain which precludes penetration of cells expressing the glycoprotein by superinfecting herpes simplex virus (1990) (92)
Anatomy of herpes simplex virus DNA. VI. Defective DNA originates from the S component (1976) (92)
Anatomy of herpes simplex virus DNA VII. alpha-RNA is homologous to noncontiguous sites in both the L and S components of viral DNA (1977) (92)
Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes. (1980) (92)
The Two Functions of Herpes Simplex Virus 1 ICP0, Inhibition of Silencing by the CoREST/REST/HDAC Complex and Degradation of PML, Are Executed in Tandem (2008) (91)
The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA (1994) (91)
The Virion Host Shutoff Protein (UL41) of Herpes Simplex Virus 1 Is an Endoribonuclease with a Substrate Specificity Similar to That of RNase A (2006) (91)
Proteins Specified by Herpes Simplex Virus (1970) (90)
Herpes simplex virus DNA in transformed cells: sequence complexity in five hamster cell lines and one derived hamster tumor (1976) (90)
The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins. (2006) (90)
The purification of poliomyelitis virus as studied by complement fixation. (1957) (90)
Regulation of herpes simplex virus 1 genes: α gene sequence requirements for transient induction of indicator genes regulated by β or late (γ2) promoters (1986) (89)
A physical difference between two strains of herpes simplex virus apparent on sedimentation in cesium chloride. (1961) (89)
Identification, properties, and gene location of a novel glycoprotein specified by herpes simplex virus 1. (1986) (89)
Mutations affecting conformation or sequence of neutralizing epitopes identified by reactivity of viable plaques segregate from syn and ts domains of HSV-1(F) gB gene. (1984) (89)
Activated MEK Suppresses Activation of PKR and Enables Efficient Replication and In Vivo Oncolysis by Δγ134.5 Mutants of Herpes Simplex Virus 1 (2006) (88)
Molecular Genetics of Herpes Simplex Virus VI. Characterization of a Temperature-Sensitive Mutant Defective in the Expression of All Early Viral Gene Products (1981) (88)
Eukaryotic Elongation Factor 1δ Is Hyperphosphorylated by the Protein Kinase Encoded by the UL13 Gene of Herpes Simplex Virus 1 (1998) (87)
The proteins specified by herpes simplex virus. I. Time of synthesis, transfer into nuclei, and properties of proteins made in productively infected cells. (1968) (87)
Separation of the Herpesvirus Deoxyribonucleic Acid Duplex into Unique Fragments and Intact Strand on Sedimentation in Alkaline Gradients (1972) (87)
Cellular Elongation Factor 1δ Is Modified in Cells Infected with Representative Alpha-, Beta-, or Gammaherpesviruses (1999) (87)
THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. I. THE PROGRAMMING OF VIRAL DNA DUPLICATION IN HEP-2 CELLS. (1963) (87)
Size and Composition of Marek's Disease Virus Deoxyribonucleic Acid (1971) (86)
Open reading frame P--a herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNA. (1996) (86)
Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression (2010) (86)
Proteins specified by herpes simplex virus. XIII. Glycosylation of viral polypeptides (1975) (86)
Isomerization of herpes simplex virus 1 genome: identification of the cis-acting and recombination sites within the domain of the a sequence (1985) (86)
The nine ages of herpes simplex virus. (2001) (86)
Ribonucleic Acid Synthesis in Cells Infected with Herpes Simplex Virus (1969) (85)
The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs (2004) (85)
The diversity and unity of Herpesviridae. (1991) (85)
UL13 protein kinase of herpes simplex virus 1 complexes with glycoprotein E and mediates the phosphorylation of the viral Fc receptor: glycoproteins E and I. (1998) (84)
UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteins (1992) (84)
Differential immunologic reactivity and processing of glycoproteins gA and gB of herpes simplex virus types 1 and 2 made in Vero and HEp-2 cells. (1981) (83)
Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1. (2001) (82)
Activation of NF-κB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis (2003) (82)
Characterization of post-translational products of herpes simplex virus gene 35 proteins binding to the surfaces of full capsids but not empty capsids (1984) (82)
Characterization and nucleotide sequence of two herpes simplex virus 1 genes whose products modulate alpha-trans-inducing factor-dependent activation of alpha genes (1987) (82)
Arrangement of Herpesvirus Deoxyribonucleic Acid in the Core (1973) (81)
Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome (1986) (81)
The essential protein encoded by the UL31 gene of herpes simplex virus 1 depends for its stability on the presence of UL34 protein. (2000) (81)
Characterization of a viable, noninverting herpes simplex virus 1 genome derived by insertion and deletion of sequences at the junction of components L and S. (1983) (80)
The herpesviruses--a biochemical definition of the group. (1969) (80)
Variability in the structural polypeptides of herpes simplex virus 1 strains: potential application in molecular epidemiology (1976) (80)
Herpes Simplex Virus 1 Induces Cytoplasmic Accumulation of TIA-1/TIAR and both Synthesis and Cytoplasmic Accumulation of Tristetraprolin, Two Cellular Proteins That Bind and Destabilize AU-Rich RNAs (2004) (79)
The Herpes Simplex Virus 1 US3 Protein Kinase Blocks Caspase-Dependent Double Cleavage and Activation of the Proapoptotic Protein BAD (2003) (79)
DNA-binding site of major regulatory protein alpha 4 specifically associated with promoter-regulatory domains of alpha genes of herpes simplex virus type 1. (1986) (79)
Genetically engineered HSV in the treatment of glioma: a review (2000) (78)
Identification of the herpes simplex virus-1 protease cleavage sites by direct sequence analysis of autoproteolytic cleavage products. (1993) (78)
Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences (1976) (77)
Regulation of herpesvirus macromolecular synthesis: nuclear retention of nontranslated viral RNA sequences. (1974) (77)
A single amino acid substitution in the cyclin D binding domain of the infected cell protein no. 0 abrogates the neuroinvasiveness of herpes simplex virus without affecting its ability to replicate. (1999) (77)
Overexpression of Promyelocytic Leukemia Protein Precludes the Dispersal of ND10 Structures and Has No Effect on Accumulation of Infectious Herpes Simplex Virus 1 or Its Proteins (2002) (76)
CHARACTERIZATION OF A FACTOR FORMED IN THE COURSE OF ADENOVIRUS INFECTION OF TISSUE CULTURES CAUSING DETACHMENT OF CELLS FROM GLASS (1958) (75)
Differentiation between alpha promoter and regulator regions of herpes simplex virus 1: the functional domains and sequence of a movable alpha regulator. (1982) (75)
The Checkpoints of Viral Gene Expression in Productive and Latent Infection: the Role of the HDAC/CoREST/LSD1/REST Repressor Complex (2011) (75)
Immunization of experimental animals with reconstituted glycoprotein mixtures of herpes simplex virus 1 and 2: protection against challenge with virulent virus. (1987) (75)
Structure and function in the herpes simplex virus 1 RNA-binding protein U(s)11: mapping of the domain required for ribosomal and nucleolar association and RNA binding in vitro (1996) (74)
RNA synthesis in cells infected with herpes simplex virus. 3. Absence of virus-specified arginyl- and seryl-tRNA in infected HEp-2 cells. (1970) (74)
Activation of herpes simplex virus 1 γ2 genes by viral DNA replication (1987) (73)
Differentiation of multiple domains in the herpes simplex virus 1 protease encoded by the UL26 gene. (1992) (73)
The role of cdc2 in the expression of herpes simplex virus genes. (2000) (73)
Anatomy of herpes simplex virus DNA. XI. Apparent clustering of functions effecting rapid inhibition of host DNA and protein synthesis (1979) (72)
Arrangement of Herpesvirus Deoxyribonucleic Acid in the Core (1972) (72)
Functional Anatomy of Herpes Simplex Virus 1 Overlapping Genes Encoding Infected-Cell Protein 22 and US1.5 Protein (1999) (72)
Herpesviridae. Definition, provisional nomenclature, and taxonomy. The Herpesvirus Study Group, the International Committee on Taxonomy of Viruses. (1981) (72)
Studies of the determinant antigens of viable cells. I. A method, and its application in tissue culture studies, for enumeration of killed cells, based on the failure of virus multiplication following injury by cytotoxic antibody and complement. (1961) (72)
The Carboxyl-Terminal Domain of RNA Polymerase II Is Phosphorylated by a Complex Containing cdk9 and Infected-Cell Protein 22 of Herpes Simplex Virus 1 (2005) (71)
Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures (2012) (71)
Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13alpha2 receptor. (2006) (71)
The UL 16 gene product of herpes simplex virus 1 is a virion protein that colocalizes with intranuclear capsid proteins. (1996) (71)
Expression of the herpes simplex virus 1 alpha transinducing factor (VP16) does not induce reactivation of latent virus or prevent the establishment of latency in mice (1991) (70)
Restriction endonuclease patterns of herpes simplex virus DNA: application to diagnosis and molecular epidemiology. (1983) (70)
The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2. (1998) (70)
Glycoprotein C-dependent attachment of herpes simplex virus to susceptible cells leading to productive infection. (1990) (69)
Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA (2007) (69)
Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts (2001) (68)
Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues (2011) (68)
The First 30 Minutes in the Life of a Virus: unREST in the Nucleus (2005) (68)
The organization of the herpes simplex virus genomes. (1979) (68)
The UL13 protein kinase and the infected cell type are determinants of posttranslational modification of ICP0. (1997) (67)
Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1. (2006) (67)
Bcl-2 Blocks a Caspase-Dependent Pathway of Apoptosis Activated by Herpes Simplex Virus 1 Infection in HEp-2 Cells (2000) (67)
The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome (1995) (66)
The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1 (1997) (66)
Ribonucleic acid synthesis in cells infected with herpes simplex virus: controls of transcription and of RNA abundance. (1972) (65)
Expression of hepatitis B virus S gene by herpes simplex virus type 1 vectors carrying alpha- and beta-regulated gene chimeras. (1984) (64)
US3 Protein Kinase of Herpes Simplex Virus 1 Blocks Caspase 3 Activation Induced by the Products of US1.5 and UL13 Genes and Modulates Expression of Transduced US1.5 Open Reading Frame in a Cell Type-Specific Manner (2002) (64)
Herpes simplex virus 1 recombinants with noninverting genomes frozen in different isomeric arrangements are capable of independent replication (1986) (63)
Polykaryocytosis induced by viruses. (1962) (63)
Guanylylation and adenylylation of the alpha regulatory proteins of herpes simplex virus require a viral beta or gamma function (1993) (63)
Regulation of herpesvirus macromolecular synthesis: evidence for multilevel regulation of herpes simplex 1 RNA and protein synthesis. (1975) (63)
The herpes simplex virus Us11 open reading frame encodes a sequence-specific RNA-binding protein (1990) (63)
Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1 (1994) (62)
The Histone Acetyltransferase CLOCK Is an Essential Component of the Herpes Simplex Virus 1 Transcriptome That Includes TFIID, ICP4, ICP27, and ICP22 (2011) (62)
Herpes simplex viruses: is a vaccine tenable? (2002) (62)
ABORTIVE INFECTION OF CANINE CELLS BY HERPES SIMPLEX VIRUS. I. CHARACTERIZATION OF VIRAL PROGENY FROM CO-OPERATIVE INFECTION WITH MUTANTS DIFFERING IN CAPACITY TO MULTIPLY IN CANINE CELLS. (1965) (62)
RIG-I–like receptor LGP2 protects tumor cells from ionizing radiation (2014) (61)
Repression of the herpes simplex virus 1 alpha 4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites. (1993) (61)
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein (2013) (60)
Protein Kinase B/Akt Is Present in Activated Form throughout the Entire Replicative Cycle of ΔUS3 Mutant Virus but Only at Early Times after Infection with Wild-Type Herpes Simplex Virus 1 (2006) (60)
The effect of the temperature of incubation on the formation and release of herpes simplex virus in infected FL cells. (1959) (59)
Differentiation and DNA contact points of host proteins binding at the cis site for virion-mediated induction of alpha genes of herpes simplex virus 1 (1988) (59)
Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling (2009) (58)
Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA (1991) (58)
miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells (2016) (58)
Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus (2010) (58)
Engagement of the Lysine-Specific Demethylase/HDAC1/CoREST/REST Complex by Herpes Simplex Virus 1 (2009) (58)
Characterization of DNA sequence-common and sequence-specific proteins binding to cis-acting sites for cleavage of the terminal a sequence of the herpes simplex virus 1 genome (1989) (58)
Demonstration of a surface difference between virions of two strains of herpes simplex virus. (1963) (57)
The Herpesviruses (1983) (57)
US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis (2011) (57)
Herpes simplex virus 1 activates cdc2 to recruit topoisomerase IIα for post-DNA synthesis expression of late genes (2003) (57)
The Herpesviruses (1983) (57)
ABORTIVE INFECTION OF CANINE CELLS BY HERPES SIMPLEX VIRUS. II. ALTERNATIVE SUPPRESSION OF SYNTHESIS OF INTERFERON AND VIRAL CONSTITUENTS. (1965) (56)
Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells. (1996) (56)
Nosocomial herpetic infections in a pediatric intensive care unit. (1981) (55)
Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0 (2001) (55)
Herpes Simplex Virus Glycoprotein gA/B: Evidence that the Infected Vero Cell Products Comap and Arise by Proteolysis (1982) (55)
Herpes Simplex Virus 1 Regulatory Protein ICP22 Interacts with a New Cell Cycle-Regulated Factor and Accumulates in a Cell Cycle-Dependent Fashion in Infected Cells (1998) (55)
Molecular genetics of herpes simplex virus. V. Characterization of a mutant defective in ability to form plaques at low temperatures and in a viral fraction which prevents accumulation of coreless capsids at nuclear pores late in infection (1981) (55)
A Novel Cellular Protein, p60, Interacting with both Herpes Simplex Virus 1 Regulatory Proteins ICP22 and ICP0 Is Modified in a Cell-Type-Specific Manner and Is Recruited to the Nucleus after Infection (1999) (55)
Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. (1999) (55)
Molecular genetics of herpes simplex virus. III. Fine mapping of a genetic locus determining resistance to phosphonoacetate by two methods of marker transfer (1979) (55)
New viral footprints in Kaposi's sarcoma. (1995) (53)
Identification of three genes nonessential for growth in cell culture near the right terminus of the unique sequences of long component of herpes simplex virus 1. (1990) (53)
The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma (2002) (53)
Glycoprotein M of Herpes Simplex Virus 1 Is Incorporated into Virions during Budding at the Inner Nuclear Membrane (2006) (53)
Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses. (2005) (52)
Herpes simplex virus glycoprotein D is sufficient to induce spontaneous pH-independent fusion in a cell line that constitutively expresses the glycoprotein. (1988) (52)
Pseudotype formation between enveloped RNA and DNA viruses (1974) (52)
US3 and US3.5 Protein Kinases of Herpes Simplex Virus 1 Differ with Respect to Their Functions in Blocking Apoptosis and in Virion Maturation and Egress (2006) (52)
The Domains of Glycoprotein D Required To Block Apoptosis Induced by Herpes Simplex Virus 1 Are Largely Distinct from Those Involved in Cell-Cell Fusion and Binding to Nectin1 (2003) (52)
Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0 (2002) (52)
Application of antibody to synthetic peptides for characterization of the intact and truncated alpha 22 protein specified by herpes simplex virus 1 and the R325 alpha 22- deletion mutant (1985) (51)
THE HOST RANGE OF HERPES SIMPLEX VIRUS; INTERFERON, VIRAL DNA, AND ANTIGEN SYNTHESIS IN ABORTIVE INFECTION OF DOG KIDNEY CELLS. (1964) (51)
The UL21 gene products of herpes simplex virus 1 are dispensable for growth in cultured cells (1994) (50)
Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3 (2013) (50)
Differentiation of the shutoff of protein synthesis by virion host shutoff and mutant gamma (1)34.5 genes of herpes simplex virus 1. (1997) (50)
Immunochemical studies of poliovirus. III. Further studies on the immunologic and physical properties of poliovirus particles produced in tissue culture. (1958) (50)
Differentiation between a promoter and regulator regions of herpes simplex virus 1: The functional domains and sequence of a movable a regulator (50)
The Stress-Inducible Immediate-Early Responsive Gene IEX-1 Is Activated in Cells Infected with Herpes Simplex Virus 1, but Several Viral Mechanisms, Including 3′ Degradation of Its RNA, Preclude Expression of the Gene (2003) (50)
The transcription and state of herpes simplex virus DNA in productive infection and in human cervical cancer tissue. (1973) (50)
The unique sequence of the herpes simplex virus 1 L component contains an additional translated open reading frame designated UL49.5 (1992) (50)
Posttranslational Processing of Infected Cell Proteins 0 and 4 of Herpes Simplex Virus 1 Is Sequential and Reflects the Subcellular Compartment in Which the Proteins Localize (2001) (50)
Expression of Gamma Interferon-Dependent Genes Is Blocked Independently by Virion Host Shutoff RNase and by US3 Protein Kinase (2008) (49)
Immunochemical studies of poliovirus. IV. Alteration of the immunologic specificity of purified poliomyelitis virus by heat and ultraviolet light. (1959) (49)
RNA synthesis in cells infected with herpes simplex virus. IX. Evidence for accumulation of abundant symmetric transcripts in nuclei (1975) (49)
Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1 (1996) (48)
Role of cdk9 in the Optimization of Expression of the Genes Regulated by ICP22 of Herpes Simplex Virus 1 (2008) (48)
Temporal cluster of herpes simplex encephalitis: investigation by restriction endonuclease cleavage of viral DNA. (1980) (47)
Replication-Competent Herpes Simplex Virus 1 Isolates Selected from Cells Transfected with a Bacterial Artificial Chromosome DNA Lacking Only the UL49 Gene Vary with Respect to the Defect in the UL41 Gene Encoding Host Shutoff RNase (2007) (47)
ReVOLT: radiation-enhanced viral oncolytic therapy. (2006) (47)
Differential response of human cells to deletions and stop codons in the gamma(1)34.5 gene of herpes simplex virus (1994) (47)
Application of the mini-Mu-phage for target-sequence-specific insertional mutagenesis of the herpes simplex virus genome. (1985) (47)
Proteins Specified by Herpes Simplex Virus IX. Contiguity of Host and Viral Proteins in the Plasma Membrane of Infected Cells (1973) (46)
Alphaherpes viral genes and their functions (2007) (46)
Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation (2014) (46)
Regulation of α Genes of Herpes Simplex Virus: The α 27 Gene Promoter-Thymidine Kinase Chimera Is Positively Regulated in Converted L Cells (1982) (46)
A novel herpes simplex virus 1 gene, UL43.5, maps antisense to the UL43 gene and encodes a protein which colocalizes in nuclear structures with capsid proteins (1996) (45)
cdc2 Cyclin-Dependent Kinase Binds and Phosphorylates Herpes Simplex Virus 1 UL42 DNA Synthesis Processivity Factor (2001) (45)
The Virion Host Shutoff RNase Plays a Key Role in Blocking the Activation of Protein Kinase R in Cells Infected with Herpes Simplex Virus 1 (2013) (45)
Virus infection of cells in mitosis. I. Observations on the recruitment of cells in karyokinesis into giant cells induced by herpes simplex virus and bearing on the site of virus antigen formation. (1961) (45)
Partial substitution of the functions of the herpes simplex virus 1 U(L)13 gene by the human cytomegalovirus U(L)97 gene. (1996) (45)
gamma 2-Thymidine kinase chimeras are identically transcribed but regulated a gamma 2 genes in herpes simplex virus genomes and as beta genes in cell genomes (1985) (44)
Wild-Type Herpes Simplex Virus 1 Blocks Programmed Cell Death and Release of Cytochrome c but Not the Translocation of Mitochondrial Apoptosis-Inducing Factor to the Nuclei of Human Embryonic Lung Fibroblasts (2000) (44)
Restriction enzyme analysis of herpesvirus DNA: stability of restriction endonuclease patterns. (1982) (44)
Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor (2006) (44)
Herpesvirus Antigens on Cell Membranes Detected by Centrifugation of Membrane-Antibody Complexes (1971) (43)
Persistence in the population: epidemiology and transmisson -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (43)
Characterization of a Recombinant Herpes Simplex Virus 1 Designed To Enter Cells via the IL13Rα2 Receptor of Malignant Glioma Cells (2005) (43)
Casein kinase II specifically nucleotidylylates in vitro the amino acid sequence of the protein encoded by the alpha 22 gene of herpes simplex virus 1. (1994) (42)
Mapping of herpes simplex virus 1 genes with mutations which overcome host restrictions to infection. (1994) (42)
The 3 facets of regulation of herpes simplex virus gene expression: A critical inquiry. (2015) (42)
In Transduced Cells, the US3 Protein Kinase of Herpes Simplex Virus 1 Precludes Activation and Induction of Apoptosis by Transfected Procaspase 3 (2007) (42)
Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces. (2005) (41)
Herpes Simplex Virus 1 ICP22 Regulates the Accumulation of a Shorter mRNA and of a Truncated US3 Protein Kinase That Exhibits Altered Functions (2005) (41)
The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site. (1997) (41)
Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins (2007) (40)
Cells Lacking NF-κB or in Which NF-κB Is Not Activated Vary with Respect to Ability To Sustain Herpes Simplex Virus 1 Replication and Are Not Susceptible to Apoptosis Induced by a Replication-Incompetent Mutant Virus (2004) (40)
Delineation of regulatory domains of early (beta) and late (gamma 2) genes by construction of chimeric genes expressed in herpes simplex virus 1 genomes. (1989) (40)
Transcription initiation sites and nucleotide sequence of a herpes simplex virus 1 gene conserved in the Epstein-Barr virus genome and reported to affect the transport of viral glycoproteins (1986) (40)
Functional interaction and colocalization of the herpes simplex virus 1 major regulatory protein ICP4 with EAP, a nucleolar-ribosomal protein. (1996) (40)
Colonization of murine ganglia by a superinfecting strain of herpes simplex virus (1983) (39)
The Domains of Glycoprotein D Required To Block Apoptosis Depend on Whether Glycoprotein D Is Present in the Virions Carrying Herpes Simplex Virus 1 Genome Lacking the Gene Encoding the Glycoprotein (2001) (39)
The Reoviridae (1983) (39)
Immunological specificity of the glycoproteins of herpes simplex virus subtypes 1 and 2. (1972) (39)
Variability of herpes simplex virus: isolation of two variants from simultaneous eruptions at different sites. (1970) (38)
Ribonucleic Acid Synthesis in Cells Infected with Herpes Simplex Virus VI. Polyadenylic Acid Sequences in Viral Messenger Ribonucleic Acid (1972) (38)
Construction and properties of a viable herpes simplex virus 1 recombinant lacking coding sequences of the alpha 47 gene (1986) (38)
Binding of the herpes simplex virus major regulatory protein to viral DNA. (1989) (38)
RNA synthesis in cells infected with herpes simplex virus. II. Evidence that a class of viral mRNA is derived from a high molecular weight precursor synthesized in the nucleus. (1969) (38)
Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene (1996) (38)
Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis (2001) (38)
Herpes Simplex Virus: Genome Size and Redundancy Studied by Renaturation Kinetics (1971) (37)
Immunobiology and Prophylaxis of Human Herpesvirus Infections (2012) (37)
The CoREST/REST Repressor Is both Necessary and Inimical for Expression of Herpes Simplex Virus Genes (2010) (37)
Cellular Compartmentalization of Herpesvirus Antigens During Viral Replication (1967) (37)
Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants. (1980) (37)
The effect of the temperature of incubation on the spread of Herpes simplex virus in an immune environment in cell culture. (1960) (36)
Application of molecular genetics to the design of live herpes simplex virus vaccines. (1982) (36)
E2F Proteins Are Posttranslationally Modified Concomitantly with a Reduction in Nuclear Binding Activity in Cells Infected with Herpes Simplex Virus 1 (2000) (36)
Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications. (2002) (36)
Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1 (1988) (35)
PML plays both inimical and beneficial roles in HSV-1 replication (2016) (35)
The Egress of Herpesviruses from Cells: the Unanswered Questions (2006) (35)
Anatomy of Bovine Mammillitis DNA I. Restriction Endonuclease Maps of Four Populations of Molecules That Differ in the Relative Orientation of Their Long and Short Components (1978) (35)
Effect of the Vinca Alkaloids on RNA Synthesis in Human Cells in vitro (1968) (35)
Induction of reactivation of herpes simplex virus in murine sensory ganglia in vivo by cadmium (1993) (35)
Molecular genetics of herpes simplex virus: the terminal a sequences of the L and S components are obligatorily identical and constitute a part of a structural gene mapping predominantly in the S component. (1979) (35)
The herpes simplex virus UL20 protein compensates for the differential disruption of exocytosis of virions and viral membrane glycoproteins associated with fragmentation of the Golgi apparatus (1994) (34)
Herpes Simplex Virus Products in Productive and Abortive Infection III. Differentiation of Infectious Virus Derived from Nucleus and Cytoplasm with Respect to Stability and Size (1968) (34)
Activation of herpes simplex virus 1 gamma 2 genes by viral DNA replication. (1987) (34)
HSV gene functions: what have we learned that could be generally applicable to its near and distant cousins? (1999) (34)
On the structure, functional equivalence, and replication of the four arrangements of herpes simplex virus DNA. (1979) (34)
Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1. (2006) (34)
Molecular targeting of gene therapy and radiotherapy. (2001) (34)
Amplification by host cell factors of a sequence contained within the herpes simplex virus 1 genome. (1990) (34)
VZV: pathogenesis and the disease consequences of primary infection -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (33)
Identification and genetic mapping of a herpes simplex virus capsid protein that binds DNA (1984) (33)
Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation. (2003) (33)
Herpes Simplex Virus Products in Productive and Abortive Infection (1968) (33)
The Herpes Simplex Virus Host Shutoff RNase Degrades Cellular and Viral mRNAs Made before Infection but Not Viral mRNA Made after Infection (2013) (33)
Cation-Independent Mannose 6-Phosphate Receptor Blocks Apoptosis Induced by Herpes Simplex Virus 1 Mutants Lacking Glycoprotein D and Is Likely the Target of Antiapoptotic Activity of the Glycoprotein (2002) (33)
Second-Site Mutation Outside of the US10-12 Domain of Δγ134.5 Herpes Simplex Virus 1 Recombinant Blocks the Shutoff of Protein Synthesis Induced by Activated Protein Kinase R and Partially Restores Neurovirulence (2002) (32)
The Role of the CoREST/REST Repressor Complex in Herpes Simplex Virus 1 Productive Infection and in Latency (2013) (32)
ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated (1991) (31)
Properties of two 5'-coterminal RNAs transcribed part way and across the S component origin of DNA synthesis of the herpes simplex virus 1 genome. (1988) (31)
Small Dense Nuclear Bodies Are the Site of Localization of Herpes Simplex Virus 1 UL3 and UL4 Proteins and of ICP22 Only When the Latter Protein Is Present (2000) (31)
Identification of a new transcriptional unit that yields a gene product within the unique sequences of the short component of the herpes simplex virus 1 genome (1993) (31)
Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription (1996) (31)
The sedimentation profiles of cytoplasmic polyribosomes in mammalian cells productively and abortively infected with herpes simplex virus. (1968) (31)
Two overlapping transcription units which extend across the L-S junction of herpes simplex virus type 1 (1995) (30)
The molecular epidemiology of herpes simplex viruses. (1979) (30)
Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1 (2011) (30)
Nuclear retention of ICP0 in cells exposed to HDAC inhibitor or transfected with DNA before infection with herpes simplex virus 1 (2008) (30)
The strategy of herpes simplex virus replication and takeover of the host cell (2007) (30)
Us9, a stable lysine-less herpes simplex virus 1 protein, is ubiquitinated before packaging into virions and associates with proteasomes. (1997) (30)
Establishment of latency in mice by herpes simplex virus 1 recombinants that carry insertions affecting regulation of the thymidine kinase gene (1985) (30)
Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity. (2007) (30)
Posttranslational Processing of Infected Cell Protein 22 Mediated by Viral Protein Kinases Is Sensitive to Amino Acid Substitutions at Distant Sites and Can Be Cell-Type Specific (2000) (30)
Characterization of the DNA of herpesviruses associated with Lucké adenocarcinoma of the frog and Burkitt lymphoma of man. (1970) (30)
Infected cell protein 22 of herpes simplex virus 1 regulates the expression of virion host shutoff gene U(L)41. (1997) (29)
The epidemiology of KSHV and its association with malignant disease -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (29)
Colocalization of the Herpes Simplex Virus 1 UL4 Protein with Infected Cell Protein 22 in Small, Dense Nuclear Structures Formed prior to Onset of DNA Synthesis (1999) (29)
Interaction of Herpes Simplex Virus ICP0 with ND10 Bodies: a Sequential Process of Adhesion, Fusion, and Retention (2013) (29)
Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase (2010) (29)
Association of a Mr 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2a and premature shutoff of protein synthesis after infection with y134.5- mutants of herpes simplex virus 1 (2005) (28)
Transcription of the derepressed open reading frame P of herpes simplex virus 1 precludes the expression of the antisense gamma(1)34.5 gene and may account for the attenuation of the mutant virus (1997) (28)
RNA Synthesis in Cells Infected with Herpes Simplex Virus VII. Control of Transcription and of Transcript Abundancies of Unique and Common Sequences of Herpes Simplex Virus 1 and 2 (1973) (28)
Regulation of glycoprotein D synthesis: does alpha 4, the major regulatory protein of herpes simplex virus 1, regulate late genes both positively and negatively? (1988) (27)
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2 (2017) (27)
The cDNA of UL15, a highly conserved herpes simplex virus 1 gene, effectively replaces the two exons of the wild-type virus (1992) (27)
Anatomy of bovine mammillitis DNA II. Size and arrangements of the deoxynucleotide sequences (1978) (27)
Expression and regulation of glycoprotein C gene of herpes simplex virus 1 resident in a clonal L-cell line (1986) (27)
Proteins specified by herpes simplex virus, IV. Site of glycosylation and accumulation of viral membrane proteins. (1970) (27)
Regulation of herpesvirus macromolecular synthesis: temporal order of transcription of alpha genes is not dependent on the stringency of inhibition of protein synthesis (1981) (27)
DNA fingerprinting in investigation of apparent nosocomial acquisition of neonatal herpes simplex. (1980) (26)
Regulation of herpesvirus macromolecular synthesis. VI. Synthesis and modification of viral polypeptides in enucleated cells (1977) (26)
The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments (2017) (26)
Herpes Simplex Virus Products in Productive and Abortive Infection I. Stabilization with Formaldehyde and Preliminary Analyses by Isopycnic Centrifugation in CsCl (1967) (26)
Translocation and Colocalization of ICP4 and ICP0 in Cells Infected with Herpes Simplex Virus 1 Mutants Lacking Glycoprotein E, Glycoprotein I, or the Virion Host Shutoff Product of the UL41 Gene (2007) (26)
RNA synthesis in cells infected with herpes simplex virus. XII. Sequence complexity and properties of RNA differing in extent of adenylation (1976) (26)
The programming of herpes virus multiplication in doubly-infected and in puromycin-treated cells. (1963) (25)
ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells (2009) (25)
Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells. (2004) (25)
Herpes Simplex Virus 1 MicroRNA miR-H28 Exported to Uninfected Cells in Exosomes Restricts Cell-to-Cell Virus Spread by Inducing Gamma Interferon mRNA (2019) (25)
Selective failure of protein synthesis in herpesvirus-infected cells deprived of arginine. (1969) (25)
Conservation of the architecture of the Golgi apparatus related to a differential organization of microtubules in polykaryocytes induced by syn- mutants of herpes simplex virus 1. (1998) (25)
An Early Regulatory Function Required in a Cell Type-Dependent Manner Is Expressed by the Genomic but Not the cDNA Copy of the Herpes Simplex Virus 1 Gene Encoding Infected Cell Protein 0 (2002) (24)
Variability, Structural Glycoproteins, and Classification of Herpes Simplex Viruses (1970) (24)
Reactivation and lytic replication of KSHV -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (24)
Abortive infection of canine cells by herpes simplex virus. 3. The interference of conditional lethal virus with an extended host range mutant. (1965) (24)
Relationship between post-transcriptional adenylation of herpes virus RNA and messenger RNA abundance. (1973) (24)
UL27.5 Is a Novel γ2 Gene Antisense to the Herpes Simplex Virus 1 Gene Encoding Glycoprotein B (1998) (23)
Introduction: objectives of herpes simplex virus vaccines seen from a historical perspective. (1991) (23)
Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis. (2003) (23)
Temperature-Sensitive Mutations in the Putative Herpes Simplex Virus Type 1 Terminase Subunits pUL15 and pUL33 Preclude Viral DNA Cleavage/Packaging and Interaction with pUL28 at the Nonpermissive Temperature (2007) (23)
RNA synthesis in cells infected with herpes simple virus. XIII. Differences in the methylation patterns of viral RNA during the reproductive cycle (1976) (23)
Interwoven Roles of Cyclin D3 and cdk4 Recruited by ICP0 and ICP4 in the Expression of Herpes Simplex Virus Genes (2010) (23)
Mutational analysis of the promoter region of the alpha 27 gene of herpes simplex virus 1 within the context of the viral genome. (1990) (23)
HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed (2013) (23)
State and Role of Src Family Kinases in Replication of Herpes Simplex Virus 1 (2006) (22)
Herpes Simplex Virus 1 Open Reading Frames O and P Are Not Necessary for Establishment of Latent Infection in Mice (2000) (22)
Herpes simplex virus virulence: the functions of the gamma (1)34.5 gene. (1997) (22)
Separation of multiple antigenic components of measles virus by equilibrium sedimentation in cesium chloride. (1962) (22)
During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins (2009) (21)
A herpes simplex virus 1 US11-expressing cell line is resistant to herpes simplex virus infection at a step in viral entry mediated by glycoprotein D (1994) (21)
The herpes simplex virus origins of DNA synthesis in the S component are each contained in a transcribed open reading frame (1987) (21)
Introduction to the human γ-herpesviruses -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (21)
Immunochemical studies of poliovirus. II. Kinetics of the formation of infectious and noninfectious type 1 poliovirus in three cell strains of human derivation. (1958) (21)
Construction and properties of a cell line constitutively expressing the herpes simplex virus glycoprotein B dependent on functional alpha 4 protein synthesis (1986) (21)
GENOME VARIATION AND EVOLUTION AMONG HERPES VIRUSES * (1980) (21)
Virus Infection of Cells in Mitosis II. Measles Virus Infection of Mitotic HEp-2 Cells.∗ (1961) (20)
Synthesis and Transport of RNA in Herpesvirus-Infected Mammalian Cells (1970) (20)
Role of alpha-transinducing factor (VP16) in the induction of alpha genes within the context of viral genomes (1991) (20)
Herpes simplex virus 1 a regulatory protein ICP 0 functionally interacts with cellular transcription factor BMAL 1 (2001) (20)
Differences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei (1992) (20)
12 Herpes Simplex Viruses (1980) (20)
The UL3 Protein of Herpes Simplex Virus 1 Is Translated Predominantly from the Second In-Frame Methionine Codon and Is Subject to at Least Two Posttranslational Modifications (1999) (19)
Buoyant Density of Herpes Simplex Virus in Solutions of Caesium Chloride (1967) (19)
KSHV-induced oncogenesis -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (19)
Truncated Forms of Glycoprotein D of Herpes Simplex Virus 1 Capable of Blocking Apoptosis and of Low-Efficiency Entry into Cells Form a Heterodimer Dependent on the Presence of a Cysteine Located in the Shared Transmembrane Domains (2002) (19)
The Nuclear-Cytoplasmic Shuttling of Virion Host Shutoff RNase Is Enabled by pUL47 and an Embedded Nuclear Export Signal and Defines the Sites of Degradation of AU-Rich and Stable Cellular mRNAs (2013) (19)
Regulation of herpes simplex virus 1 genes: alpha gene sequence requirements for transient induction of indicator genes regulated by beta or late (gamma 2) promoters. (1986) (19)
Virus infection of cells in mitosis. III. Cytology of mitotic and amitotic HEp-2 cells infected with measles virus. (1962) (19)
Macromolecular biosynthesis in animal cells infected with cytolytic viruses. (1969) (19)
Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow (2007) (18)
The phenotype in vitro and in infected cells of herpes simplex virus 1 alpha trans-inducing factor (VP16) carrying temperature-sensitive mutations introduced by substitution of cysteines (1995) (18)
Chicken ovalbumin gene fused to a herpes simplex virus alpha promoter and linked to a thymidine kinase gene is regulated like a viral gene (1982) (18)
Ribonucleic acid synthesis in cells infected with herpes simplex virus: characterization of viral high molecular weight nuclear RNA. (1975) (18)
HerpesSimplex Virus 1 Mutant in Which the ICP0 HUL-1 E3 Ubiquitin Ligase SiteIs Disrupted Stabilizes cdc34 but Degrades D-Type Cyclins andExhibits DiminishedNeurotoxicity (2003) (18)
Herpes Simplex Virus 1 Precludes Replenishment of the Short-Lived Receptor of Tumor Necrosis Factor Alpha by Virion Host Shutoff-Dependent Degradation of Its mRNA (2006) (18)
Herpes simplex virus expressing Epstein-Barr virus nuclear antigen 1. (1986) (18)
The heterogenous regions in herpes simplex virus 1 DNA. (1983) (18)
hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells (2020) (18)
miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner. (2018) (18)
Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage (2015) (17)
The α promoter regulator-ovalbumin chimeric gene resident in human cells is regulated like the authentic α 4 gene after infection with herpes simplex virus 1 mutants in α 4 gene (1983) (17)
Role of Herpes Simplex Virus ICP0 in the Transactivation of Genes Introduced by Infection or Transfection: a Reappraisal (2010) (17)
Processing of the herpes simplex virus regulatory protein a 22 mediated by the UL 13 protein kinase determines the accumulation of a subset of a and y mRNAs and proteins in infected cells (2005) (17)
Cytotoxic T cells specific for cytomegalovirus : a potential therapy for immunocompromised patients. Discussion (1991) (17)
Herpesviruses: Current Information on the Composition and Structure (1971) (17)
Alphaherpes viral genes and their functions -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (17)
Primate betaherpesviruses -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (17)
Immunobiology and host response -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (17)
Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia (2015) (17)
Herpesviruses, latency and cancer: a biochemical approach. (1974) (17)
Reversible inhibition of herpes simplex multiplication in HEp-2 cells with phenethyl alcohol. (1963) (17)
Overexpression of the Ubiquitin-Specific Protease 7 Resulting from Transfection or Mutations in the ICP0 Binding Site Accelerates Rather than Depresses Herpes Simplex Virus 1 Gene Expression (2012) (17)
Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo (2001) (17)
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Proteins Specified byHerpes Simplex Virus X.Staining andRadiolabeling Properties ofBCapsid andVirion Proteins inPolyacrylamide Gels (1974) (16)
Further studies of variants of herpes simplex virus that produce syncytia or pocklike lesions in cell cultures. (1961) (16)
Comparative analysis of herpesvirus-common proteins -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (16)
Differentiation of nuclear and cytoplasmic herpesvirus antigens in infected cells. (1966) (16)
The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes (2009) (16)
Regulation of herpesvirus macromolecular synthesis. VII. Inhibition of internal methylation of mRNA late in infection. (1978) (16)
Mapping of Key Functions of the Herpes Simplex Virus 1 US3 Protein Kinase: the US3 Protein Can Form Functional Heteromultimeric Structures Derived from Overlapping Truncated Polypeptides (2006) (16)
Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome. (2000) (15)
Comparative analysis of the genomes -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (15)
Some biophysical properties of frog viruses and their DNA. (1966) (15)
Comparative virion structures of human herpesviruses -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (15)
Marek's disease herpes virus: a cytomegalovirus. (1969) (14)
The Interaction of Herpes Simplex Virus 1 Regulatory Protein ICP22 with the cdc25C Phosphatase Is Enabled In Vitro by Viral Protein Kinases US3 and UL13 (2008) (14)
The molecular basis of herpes simplex virus pathogenicity (1994) (14)
Herpes Simplex and Epstein-Barr Viruses in Human Cells and Tissues: A Study in Contrasts (1975) (14)
The destruction of smallpox virus stocks in national repositories: a grave mistake and a bad precedent. (1994) (14)
Mutational analysis of the ICP4 binding sites in the 5' transcribed noncoding domains of the herpes simplex virus 1 UL 49.5 gamma 2 gene (1992) (14)
Reviews and Notes: Infectious Diseases: Infectious Diseases in an Age of Change: The Impact of Human Ecology and Behavior on Disease Transmission (1996) (14)
The role of hormones in viral infections. I. Suppression of viral adsorption and penetration into cells treated with parathyroid hormone in vitro. (1962) (14)
THE INHIBITION OF HERPES SIMPLEX VIRUS MULTIPLICATION BY NUCLEOSIDES. (1965) (13)
Immunological reactivity of herpes simplex virus 1 and 2 polypeptides electrophoretically separated and transferred to diazobenzyloxymethyl paper (1981) (13)
Herpes simplex virus 1 reiterated S component sequences (c1) situated between the a sequence and alpha 4 gene are not essential for virus replication (1985) (13)
Entry of alphaherpesviruses into the cell -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (13)
Analyses of HSV Proteins for Posttranslational Modifications and Enzyme Functions. (1998) (13)
Pathogenesis and disease -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (13)
Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection (2018) (12)
Enhancement of Oncolytic Activity of oHSV Expressing IL-12 and Anti PD-1 Antibody by Concurrent Administration of Exosomes Carrying CTLA-4 miRNA (2019) (12)
An improved procedure for H-3 and C-14 counting in acrylamide gels with a nonaqueous scintillation system. (1968) (12)
Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence. (2002) (11)
Genetic variation of viruses. (1980) (11)
Studies of polyoma virus. I. Hemagglutination as a measure of virus mass and antibody to the virus. (1960) (11)
Y2-Thymidine Kinase Chimeras AreIdentically Transcribed but Regulated as Y2 GenesinHerpesSimplex Virus Genomesandas GenesinCell Genomes (1985) (11)
Virus entry into host, establishment of infection, spread in host, mechanisms of tissue damage -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (11)
HHV-6A, 6B, and 7: persistence in the population, epidemiology and transmission -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (11)
Early events in human cytomegalovirus infection -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (10)
Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA (2007) (10)
Studies of polyoma virus. II. Characteristics of tumor production, antibody response, and recovery of virus from tumors in the syrian hamster. (1960) (10)
The Stability of Herpes Simplex Virus 1 ICP0 Early after Infection Is Defined by the RING Finger and the UL13 Protein Kinase (2014) (10)
Genetic engineering of viruses and of virus vectors: a preface. (1996) (10)
Oct-1 Is Posttranslationally Modified and Exhibits Reduced Capacity To Bind Cognate Sites at Late Times after Infection with Herpes Simplex Virus 1 (2003) (10)
Bcl-2 Blocks Accretion or Depletion of Stored Calcium but Has No Effect on the Redistribution of IP3 Receptor I Mediated by Glycoprotein E of Herpes Simplex Virus 1 (2007) (10)
Failure to induce cervical cancer in mice by long‐term frequent vaginal exposure to live or inactivated herpes simplex viruses (1986) (10)
Herpes Simplex Virus 1 Mutant in Which the ICP0 HUL-1 E3 Ubiquitin Ligase Site Is Disrupted Stabilizes cdc34 but Degrades D-Type Cyclins and Exhibits Diminished Neurotoxicity (2003) (10)
Human herpersviruses I: a model for molecular organization and regulation of herpesviruses-a review. (1975) (10)
Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus. (2003) (10)
Immediate–early viral gene regulation and function -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (9)
The glycoprotein C gene of herpes simplex virus 1 resident in clonal L cell lines manifests two regulatory domains conferring a dominant B and a subordinate gamma 2 regulation. (1988) (9)
Overview of classification -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (9)
Expression of hepatitis B virus S gene by herpes simplex virus type 1 vectors carrying a- and ,8-regulated gene chimeras (9)
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Molecular basis of HSV latency and reactivation -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (9)
Characterization of a herpes simplex virus sequence which binds a cellular protein as either a single-stranded or double-stranded DNA or RNA (1992) (9)
The trans-activation of herpes simplex virus gene expression: comparison of two factors and their cis sites. (1988) (9)
Role of Cellular Phosphatase cdc25C in Herpes Simplex Virus 1 Replication (2008) (8)
Cellular proteins specifically bind single- and double-stranded DNA and RNA from the initiation site of a transcript that crosses the origin of DNA replication of herpes simplex virus 1. (1989) (8)
Preparation of High Potency Poliovirus in FL Cell Cultures at Room Temperature.∗ (1959) (8)
Genetic comparison of human alphaherpesvirus genomes -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (8)
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Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression (2012) (7)
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Regulation of alpha genes of herpes simplex virus: the alpha 27 gene promoter-thymidine kinase chimera is positively regulated in converted L cells. (1982) (7)
The use of intertypic recombinants for analysis of gene organization in herpes simplex virus. (1978) (7)
Comparative genome and virion structure -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (6)
Herpes Simplex Viruses, Central Nervous System, and Encephalitis (1992) (6)
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The alpha promoter regulator-ovalbumin chimeric gene resident in human cells is regulated like the authentic alpha 4 gene after infection with herpes simplex virus 1 mutants in alpha 4 gene. (1983) (6)
[Concentration and partial purification of adenovirus type 2 complement-fixing antigen]. (1958) (6)
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The regulations of gamma (structural) polypeptide synthesis in herpes simplex virus types 1 and 2 infected cells. (1978) (6)
Gammaherpesviruses entry and early events during infection -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (5)
The role of hormones in viral infection. II. Acceleration of viral adsorption and penetration into cells treated with thyroid hormone in vitro. (1962) (5)
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The Range and Distribution of Murine Central Nervous System Cells Infected with the g134.5 (1997) (5)
Analyses of transplanted murine tumors for HSV DNA sequences (1986) (5)
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Linear and parabolic estimates of the titers of herpes simplex from pock counts on the chorioallantoic membrane of embryonated eggs. (1960) (5)
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Variability intheStructural Polypeptides ofHerpes Simplex Virus1Strains: Potential Application inMolecular Epidemiology (1976) (5)
Evasion and Obstruction The Central Strategy of the Interaction of (1998) (5)
EBV and KSHV – related herpesviruses in non-human primates -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (5)
Colocalization of the Herpes Simplex Virus 1 UL4 Protein with Infected Cell Protein 22 in Small, Dense Nuclear Structures Formed prior to Onset of DNA Synthesis (1999) (5)
Cell-specific selection of mutants of a herpes simplex virus recombinant carrying deletions. (1985) (5)
The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US 5, US 4, US 3, US 2 and α22 (2010) (4)
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VZV: molecular basis of persistence (latency and reactivation) -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (4)
Antiviral therapy of varicella-zoster virus infections -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (4)
Regulation of α and γ Gene Expression in Cells Infected with Herpes Simplex Viruses (1993) (4)
Proteins Specified byHerpesSimplex Virus VIII. Characterization andComposition ofMultiple Capsid FormsofSubtypes 1and2 (1972) (4)
A post-alpha gene function turns off the capacity of a host protein to bind DNA in cells infected with herpes simplex virus 1 (1984) (4)
Early viral gene expression and function -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (4)
Envelopment of herpes simplex virus nucleocapsids at the inner nuclear membrane -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (3)
DNA synthesis and late viral gene expression -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (3)
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Enhancement of Oncolytic Activity of oHSV Expressing IL-12 and Anti PD-1 Antibody by Concurrent Administration of Exosomes Carrying CTLA-4miRNA (2019) (3)
Monkey B virus -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (3)
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Differentiation of the process of cell infection with free herpes simplex virus from the recruitment of cells into virus-induced syncytia in x-rayed cell cultures. (1961) (3)
GADD45γ Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes (2019) (3)
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Herpesviruses as therapeutic agents -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (3)
The Regulation of α Genes of Herpes Simplex Virus 1 (1984) (3)
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Genetic engineering and properties of novel herpes simplex viruses for use as potential vaccines and as vectors of foreign genes. (1989) (3)
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Simplex Virus DNA in Clinical Samples Quantitative Assay for Detecting Herpes Development of a High-Throughput (1999) (3)
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Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1. (2005) (2)
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The (cid:103) 1 34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1 (cid:97) to dephosphorylate the (cid:97) subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase (1997) (1)
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The Interaction of Herpes Simplex Virus 1 Regulatory Protein ICP22 with the cdc25C Phosphatase Is Enabled In Vitro by Viral Protein Kinases U S 3 and U L 13 (cid:1) (2008) (0)
II The morality of scientists (1987) (0)
On the function of the ICP 27, an alpha gene product of herpes simplex virus (1990) (0)
Recombinants with Noninverting Genomes (0)
Roizman Caspase-Dependent Pathways to Cell Death Caspase-3-Independent and Herpes Simplex Virus 1 Blocks (1999) (0)
HerpesSimplex Virus 1 Reiterated SComponent Sequences (c1) Situated Betweenthea Sequence andcx4GeneAreNotEssential (1985) (0)
VIRUS HSV PRESENTANT UNE CARENCE EN Ϝ134.5 ET VOIE MAPK (2007) (0)
[Effect of antibodies and temperature on the dynamics of virus infections of cells in tissue culture]. (1960) (0)
Origin of DNA Synthesis, and Several Genes Including Those Specifying Glycoprotein E and the ac47 Gene (0)
The use of concomitant radiotherapy and an attenuated herpes simplex-1 virus improves survival, in intracranial glioblastoma multiforme tumors (astro research fellowship) (1998) (0)
The herpesviruses, vol. 3. Plenum Press, New York, London (1985), 1 vol. (17 × 25,5 cm) 416 + xv pages (1986) (0)
Treatment of tumor diseases with modified HSV (1993) (0)
Problems and Significance of Varying Reproductive Capacity of Poliovirus and Other Viruses at Different Temperatures -- 1959? -- Poliomyelitis, Conferences/Committees -- letter, 1959-11-18 (1959) (0)
Subject Index, Vol. 15, 1981 (1981) (0)
2021 Enhanced replication of attenuated HSV-1 in irradiated human glioma xenografts (1997) (0)
Engagement of the Lysine-Speciﬁc Demethylase/HDAC1/CoREST/REST Complex by Herpes Simplex Virus 1 (cid:1) (2009) (0)
The herpesviruses, vol. 4. Plenum Press, New York, London (1985), Immunobiologie and prophylaxie of human herpesvirus infections. 1 vol. (17 × 25,5 cm), 430 + xviii pages (1986) (0)
RIG-1-Like Receptor LGP2 Protects Tumor Cells From Ionizing Radiation (2014) (0)
Virology: Viruses, Evolution and Cancer . Basic Considerations. Proceedings of a conference, Montreal, Aug. 1973. Edouard Kurstak and Karl Maramorosch, Eds. Academic Press, New York, 1974. xxxii, 814 pp., illus. $48.50. (1975) (0)
Overexpression of the Ubiquitin-Speciﬁc Protease 7 Resulting from Transfection or Mutations in the ICP0 Binding Site Accelerates Rather than Depresses Herpes Simplex Virus 1 Gene Expression (2012) (0)
Porphyrin and Phthalocyanine Antiscrapie Compounds (2000) (0)
Procedes et compositions de stimulation virale d'elimination de cellules (1996) (0)
In Transduced Cells, the U S 3 Protein Kinase of Herpes Simplex Virus 1 Precludes Activation and Induction of Apoptosis by Transfected Procaspase 3 (cid:1) (2007) (0)
RNA Synthesis inCells Infected withHerpes Simplex Virus VII.Control ofTranscription andofTranscript Abundancies ofUnique andCommonSequences ofHerpes Simplex Virus 1and2 (1973) (0)
Systemic delivery by intravenous injection of gamma-1-34.5-deleted HSV-1 for oncolytic viral therapy (2007) (0)
Ahead of the Curve: David Baltimore's Life in Science (review) (2002) (0)
MIAREK'S DISEASE HERPES VIRU S: A CYTOMIEGALOVIRUlS?* (0)
Herpes Simplex Virus: Aspects of Structure and Regulation of Viral Rna and Protein Synthesis (1975) (0)
Study on the function of the alpha 47 gene product of the Herpes simplex virus 1. (1989) (0)
Herpes simplex virus vaccines: How close are we? (1992) (0)
Mutational analysis of the promoter region of the a 27 gene of herpes simplex virus 1 within the context of the viral genome ( scanning mutations / a-trans-inducing factor / mRNA synthesis / DNA binding proteins ) (0)
Human Herpesviruses: Plate section (2007) (0)
Mapping of the Major Viral Glycoproteins and of the Genetic Loci (0)
Molecular Genetics ofHerpes Simplex Virus VI.Characterization ofaTemperature-Sensitive MutantDefective inthe Expression ofAllEarly Viral GeneProducts (1981) (0)
Cell type dependence of herpes simplex virus gene expression and of processing of viral protein. (1987) (0)
Guidelines for investigation of allegations of dishonesty in research. (1987) (0)
2042 A novel therapeutic approach for hepatocellular carcinoma using replication-competent herpes simplex virus and ionizing radiation (1999) (0)
Letter from Bernard Roizman, Committee on Virology, University of Chicago to Harold Varmus (1985) (0)
Posttranscriptional regulation of US11 in cells infected with a herpes simplex virus 1 recombinant lacking both 222-bp domains containing S-component origins of DNA synthesis. (1999) (0)
Increased effi cacy of an interleukin-12- secreting herpes simplex virus in a syngeneic intracranial murine glioma model1 (2005) (0)
640 Stat1 as mediator of acquired tumor radioresistance and potential target for anti-tumor therapy (2004) (0)
PROCEEDINGS, XI INTERNATIONAL CANCER CONGRESS, FLORENCE 1974: a model for molecular organization of herpesvirus virions and their DNA (1975) (0)
Regulation ofGlycoprotein D Synthesis: Doeso4, theMajor Regulatory Protein ofHerpesSimplex Virus1,Regulate LateGenes BothPositively andNegatively? (1988) (0)
Bernard Roizman Cells 2 Receptor of Malignant Glioma α the IL 13 R viaSimplex Virus 1 Designed To Enter Cells Characterization of a Recombinant Herpes (2005) (0)
Genetic variation of viruses. Introductory remarks. (1980) (0)
Identification byAntibody toa Synthetic Peptide ofa Protein Specified bya Diploid GeneLocated intheTerminal Repeats ofthe L Component ofHerpesSimplex VirusGenome (1986) (0)
Bernard Roizman the Host Cell by Herpes Simplex Virus 1 Role of ICP 0 in the Strategy of Conquest of (2004) (0)
Genetically modified herpes virus for the treatment of cardiac and vascular diseases (2001) (0)
Increasing the Therapeutic Ratio of Oncolysis by Optimally Integrating Radiotherapy into the Replicative Cycle of Oncolytic HSV-1 for High Grade Gliomas (2009) (0)
Radiation Assisted Viral Oncolytic Therapy (RaVOLT): IR Activates HSV-1 Viral Promoters to Enhance Viral Replication and Tumor Eradication (2005) (0)
Regulatory Protein of Herpes Simplex Virus 1, Regulate Late Genes (0)
Deoxyribonucleic Acid Marek's Disease Virus Size and Composition of (2013) (0)
TheHerpesSimplex VirusOrigins ofDNA Synthesis intheS Component AreEachContained ina Transcribed Open Reading Frame (1987) (0)
Membrane-associated antigens of herpes simplex virus. Discussion (1991) (0)
Activated MEK Suppresses Activation of PKR and Enables Efﬁcient Replication and In Vivo Oncolysis by (cid:2)(cid:3) 1 34.5 Mutants of Herpes Simplex Virus 1 (2006) (0)
H-102 The detente between herpes simplex viruses and their human host (2018) (0)
Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 a genes ( a-trans-induction factor / gel assay / DNase I / DNA-protein complexes ) (0)
Ribonucleic Acid Synthesis in Cells Infected with Herpes Simplex Virus : Controls of Transcription and of RNA Abundance * ( hybridization / nucleases / mammalian cells (0)
(VP16) in the Induction of ca Genes within the Context of Viral Genomes (0)
Immunotherapy of HSV infections – antibody delivery -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (0)
Deoxyribonucleic Acid of Herpes Simplex Virus (2003) (0)
Identification of a novel MEK signaling pathway that determines tumor selective replication of herpes simplex type-1 (HSV-1) viruses in pancreatic cancer (2005) (0)
[Definition of a critical thermosensitive event in the cycle of the poliovirus]. (1962) (0)
Genetically engineered herpes viruses for the treatment of tumors (2000) (0)
The Adenoviruses (1984) (0)
Expression of the late (g2) genes in herpes simplex virus 1 (HSV-1). Analysis of the binding sites for the major viral regulatory portein, ICP 4, in the 5' transcribed non coding domain of a late gene (1989) (0)
Mapping ofFunctional andAntigenic Domainsofthe(x4Protein of HerpesSimplex Virus 1 (1988) (0)
Tumor Cells Regulates Both Cytotoxic and Prosurvival Functions in Signal Transducer and Activator of Transcription 1 (2007) (0)
Nomenclature and classification of herpesviruses: a proposal. (1972) (0)
Adoptive immunotherapy for herpesviruses -- Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis (2007) (0)
Gabriella Glycoproteins Lacking Intact Genes Expressing Both by a Herpes Simplex Virus 1 Mutant Blocks Apoptosis in SKN-SH Cells Induced trans Glycoprotein D or J Delivered in (2000) (0)
TheULllGeneofHerpesSimplex Virus1Encodes aFunction ThatFacilitates Nucleocapsid Envelopment andEgress fromCells (1992) (0)

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