Bernard Thorens

Q: What Schools Are Affiliated With Bernard Thorens

Bernard Thorens is affiliated with the following schools: University of Lausanne, Massachusetts Institute of Technology, University of Bern, University of Geneva

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Bernard Thorens

Philosophy

#4657

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#7256

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Logic

#2070

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#2973

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Philosophy

Bernard Thorens's Degrees

PhD Molecular Biology University of Geneva
Masters Biochemistry University of Geneva

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Bernard Thorens's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation (2010) (2119)
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits (1994) (1980)
Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. (1992) (908)
The SLC2 (GLUT) family of membrane transporters. (2013) (891)
Glucose transporters in the 21st Century. (2010) (793)
The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (2001) (715)
Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells (1988) (662)
Uric acid transport and disease. (2010) (618)
Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor (1993) (539)
Insulin Resistance, Hyperlipidemia, and Hypertension in Mice Lacking Endothelial Nitric Oxide Synthase (2001) (538)
The SLC2 family of facilitated hexose and polyol transporters (2004) (497)
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice (2000) (461)
International Union of Pharmacology. XXXV. The Glucagon Receptor Family (2003) (457)
GLUT2, glucose sensing and glucose homeostasis (2015) (420)
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. (2002) (389)
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. (2005) (379)
Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation (1987) (348)
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 (1997) (338)
Brain glucose sensing, counterregulation, and energy homeostasis. (2007) (322)
Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. (1996) (320)
The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing (2014) (314)
Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice. (2008) (302)
GLUT2 is a high affinity glucosamine transporter (2002) (300)
Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels* (1997) (297)
Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. (2002) (294)
Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. (2001) (256)
GLUTX1, a Novel Mammalian Glucose Transporter Expressed in the Central Nervous System and Insulin-sensitive Tissues* (2000) (249)
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. (2004) (249)
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation (2017) (244)
Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells. (1990) (236)
Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors. (2005) (232)
Identification of a mammalian H+‐myo‐inositol symporter expressed predominantly in the brain (2001) (229)
Stimulation of hematopoiesis in vivo by recombinant bacterial murine interleukin 3. (1986) (227)
VAMP‐2 and cellubrevin are expressed in pancreatic beta‐cells and are essential for Ca(2+)‐but not for GTP gamma S‐induced insulin secretion. (1995) (225)
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy (2009) (225)
Expression and Functional Activity of Glucagon, Glucagon-Like Peptide I, and Glucose-Dependent Insulinotropic Peptide Receptors in Rat Pancreatic Islet Cells (1996) (224)
Molecular Physiology of Glucose Transporters (1990) (218)
Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor. (1997) (216)
Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. (1998) (208)
Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice. (2000) (205)
Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. (1989) (205)
The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. (1990) (196)
Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk (2019) (183)
Expression of the Glucagon‐Like Peptide‐1 Receptor Gene in Rat Brain (1996) (180)
Brain glucose sensing and neural regulation of insulin and glucagon secretion (2011) (178)
Differences in Glucose Transporter Gene Expression between Rat Pancreatic α- and β-Cells Are Correlated to Differences in Glucose Transport but Not in Glucose Utilization (*) (1995) (176)
Glucose transporter gene expression in early mouse embryos. (1991) (174)
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. (2003) (172)
Transgenic Reexpression of GLUT1 or GLUT2 in Pancreatic β Cells Rescues GLUT2-null Mice from Early Death and Restores Normal Glucose-stimulated Insulin Secretion* (2000) (170)
The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment. (1992) (170)
Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. (1988) (170)
Simple‐sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2‐null mice (2003) (169)
Cloning, Functional Expression, and Chromosomal Localization of the Human Pancreatic Islet Glucose-Dependent Insulinotropic Polypeptide Receptor (1995) (166)
Ins1Cre knock-in mice for beta cell-specific gene recombination (2014) (163)
Gonadotropin-releasing hormone secretion from hypothalamic neurons: stimulation by insulin and potentiation by leptin. (2003) (161)
Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. (1990) (155)
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. (2012) (154)
Normal kinetics of intestinal glucose absorption in the absence of GLUT2: Evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum (2001) (152)
Glucose uptake, utilization, and signaling in GLUT2-null islets. (2000) (150)
Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion (1986) (148)
Facilitated glucose transporters in epithelial cells. (1993) (145)
Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans. (2017) (143)
Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain—an immunohistochemical study (2004) (141)
Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas. (1995) (140)
Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway (2008) (139)
Portal glucose infusion in the mouse induces hypoglycemia: evidence that the hepatoportal glucose sensor stimulates glucose utilization. (2000) (137)
The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response. (2016) (135)
Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. (2006) (132)
Dexamethasone Induces Posttranslational Degradation of GLUT2 and Inhibition of Insulin Secretion in Isolated Pancreatic β Cells (1997) (130)
Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension. (2004) (130)
Glucagon-Like Peptide-I and the Control of Insulin Secretion in the Normal State and in NIDDM (1993) (130)
The Glucagon Receptor Family (2000) (127)
Molecular and cellular physiology of GLUT-2, a high-Km facilitated diffusion glucose transporter. (1992) (127)
Hepatic glucose sensing is required to preserve β cell glucose competence. (2013) (124)
Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment (2015) (121)
GLUT2 in pancreatic and extra-pancreatic gluco-detection (2001) (121)
Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop (2009) (119)
Neural regulation of pancreatic islet cell mass and function (2014) (119)
Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes. (1998) (117)
Differential localization of two glucose transporter isoforms in rat kidney. (1990) (115)
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes (2017) (114)
Mouse GLUT9: evidences for a urate uniporter. (2009) (108)
Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion. (2014) (107)
Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1. (1999) (102)
The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing. (2013) (102)
Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice (2011) (100)
Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development. (1992) (100)
Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight. (2011) (99)
Lentivirus-mediated Bcl-2 expression in βTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion (1999) (99)
Vitamin D--dependent calcium binding protein: immunocytochemical localization in chick kidney. (1981) (97)
Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. (2011) (95)
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. (2008) (94)
Transcript Profiling Suggests That Differential Metabolic Adaptation of Mice to a High Fat Diet Is Associated with Changes in Liver to Muscle Lipid Fluxes* (2004) (90)
Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3',5'-monophosphate levels and beta-cell glucose competence. (1998) (90)
Immunocytochemical localization of the glucose transporter 2 (GLUT2) in the adult rat brain. II. Electron microscopic study (2004) (89)
Reduced beta-cell glucose transporter in new onset diabetic BB rats. (1990) (89)
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 (1998) (87)
Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress (2014) (85)
Glucagon-like Peptide-1 Increases β-Cell Glucose Competence and Proliferation by Translational Induction of Insulin-like Growth Factor-1 Receptor Expression* (2010) (85)
Glucose responsive neurons of the paraventricular thalamus control sucrose-seeking behavior (2016) (85)
Glucagon-like peptide-1-(7-36) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line. (1993) (85)
Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines. (1994) (84)
Glucagon-like peptide-1 and control of insulin secretion. (1995) (83)
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass (2014) (82)
Differential Regulation of Two Glucose Transporters in Rat Liver by Fasting and Refeeding and by Diabetes and Insulin Treatment (1990) (81)
Sensing of glucose in the brain. (2012) (80)
Glut2‐dependent glucose‐sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons (2010) (79)
Gut-derived signaling molecules and vagal afferents in the control of glucose and energy homeostasis (2004) (79)
LKB1 and AMPK differentially regulate pancreatic β-cell identity (2014) (79)
Internalization and homologous desensitization of the GLP-1 receptor depend on phosphorylation of the receptor carboxyl tail at the same three sites. (1997) (78)
Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion. (2001) (78)
Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate. (1996) (77)
Immunocytochemical localization of the vitamin D-dependent calcium binding protein in chick duodenum (1982) (77)
Liver Hyperplasia and Paradoxical Regulation of Glycogen Metabolism and Glucose-sensitive Gene Expression in GLUT2-null Hepatocytes (2000) (76)
Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. (2006) (75)
Glucose transporters in the 21 st Century (2010) (74)
Glucose sensing and the pathogenesis of obesity and type 2 diabetes (2008) (72)
Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group. (2017) (72)
Regulation of adaptive behaviour during fasting by hypothalamic Foxa2 (2009) (72)
Protein Kinase A-dependent Phosphorylation of GLUT2 in Pancreatic Cells (*) (1996) (71)
Dominant Negative MyD88 Proteins Inhibit Interleukin-1β/Interferon-γ-mediated Induction of Nuclear Factor κB-dependent Nitrite Production and Apoptosis in β Cells* (2000) (70)
Regulated exocytosis of an H+/myo‐inositol symporter at synapses and growth cones (2004) (69)
Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice. (2013) (67)
Peroxisomal and Microsomal Lipid Pathways Associated with Resistance to Hepatic Steatosis and Reduced Pro-inflammatory State* (2010) (65)
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. (2003) (65)
Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice (2013) (65)
Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis. (2014) (64)
Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14 (2008) (63)
Brain glucose sensing in homeostatic and hedonic regulation (2015) (62)
α-cell glucokinase suppresses glucose-regulated glucagon secretion (2018) (61)
Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy (2014) (60)
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration (2020) (59)
Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells (1998) (59)
SOCS-1 Protein Prevents Janus Kinase/STAT-dependent Inhibition of β Cell Insulin Gene Transcription and Secretion in Response to Interferon-γ* (2001) (58)
Differential Sensitivity of GLUT1- and GLUT2-Expressing β Cells to Streptozotocin (2001) (57)
The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic β cells (2003) (57)
Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice (2016) (56)
Impaired Glucose Homeostasis in Mice Lacking the α1b-Adrenergic Receptor Subtype* (2004) (56)
GLUT8 Is Dispensable for Embryonic Development but Influences Hippocampal Neurogenesis and Heart Function (2006) (53)
cFLIP Protein Prevents Tumor Necrosis Factor-α–Mediated Induction of Caspase-8–Dependent Apoptosis in Insulin-Secreting βTc-Tet Cells (2002) (53)
Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose. (1990) (53)
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development (2013) (52)
Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy (2007) (52)
Inhibition of glucose‐induced insulin secretion by long‐term preexposure of pancreatic islets to leptin (1997) (51)
Evidence from oocyte expression that the erythrocyte water channel is distinct from band 3 and the glucose transporter. (1991) (50)
Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice. (2008) (50)
In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice (2011) (50)
Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons. (2002) (49)
Heterologous Desensitization of the Glucagon-like Peptide-1 Receptor by Phorbol Esters Requires Phosphorylation of the Cytoplasmic Tail at Four Different Sites* (1996) (49)
Reduction in the expression of glucose transporter protein GLUT 2 in preneoplastic and neoplastic hepatic lesions and reexpression of GLUT 1 in late stages of hepatocarcinogenesis. (1993) (48)
Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells (2013) (47)
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes. (2020) (46)
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance (2011) (45)
Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores (2016) (45)
The roles of granulocyte-macrophage colony-stimulating factor and interleukin 3 in stromal cell-mediated hemopoiesis in vivo. (1988) (44)
Immunolocalization of GLUTX1 in the Testis and to Specific Brain Areas and Vasopressin- Containing Neurons. (2002) (44)
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. (2012) (44)
Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway. (2002) (44)
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. (2008) (43)
Encapsulated, Genetically Engineered Cells, Secreting Glucagon‐like Peptide‐1 for the Treatment of Non‐insulin‐dependent Diabetes Mellitus (1999) (41)
Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted β-cells (1995) (41)
Central control of glucose homeostasis: the brain--endocrine pancreas axis. (2010) (41)
Expression of the human erythrocyte glucose transporter in Escherichia coli. (1988) (40)
GLUT2 surface expression and intracellular transport via the constitutive pathway in pancreatic beta cells and insulinoma: evidence for a block in trans-Golgi network exit by brefeldin A (1993) (40)
A gene knockout approach in mice to identify glucose sensors controlling glucose homeostasis (2002) (40)
The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids. (2013) (40)
Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells. (2000) (39)
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion (2017) (38)
Neurochemical profile of the mouse hypothalamus using in vivo 1H MRS at 14.1T (2010) (37)
Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength (2014) (37)
The loss of GLUT2 expression in the pancreatic β-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors (1997) (37)
Glucose‐dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): Cellular localization, lesion‐affected expression, and impaired regenerative axonal growth (2009) (37)
Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function (2015) (37)
Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin. (2001) (36)
Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice (2009) (35)
Glucose transporter isotypes switch in T-antigen-transformed pancreatic beta cells growing in culture and in mice (1992) (35)
Type 2 Diabetes, SGLT2 Inhibitors, and Glucose Secretion. (2015) (35)
Lipoprotein Lipase and Leptin Are Accumulated in Different Secretory Compartments in Rat Adipocytes* (2001) (35)
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes (2021) (34)
Bone marrow pre‐B lymphocytes synthesize immunoglobulin mu chains of membrane type with different properties and intracellular pathways. (1985) (33)
The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines. (2003) (32)
Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice. (2013) (32)
Plac8 is required for White Adipocyte Differentiation in vitro and Cell Number Control in vivo (2012) (31)
GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons. (2005) (30)
Heterogeneous secretion of individual B cells in response to D-glucose and to nonglucidic nutrient secretagogues. (1995) (30)
Glutamine Stimulates Biosynthesis and Secretion of Insulin-like Growth Factor 2 (IGF2), an Autocrine Regulator of Beta Cell Mass and Function* (2014) (30)
Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet–Induced Hepatic Steatosis (2011) (29)
Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells. (2003) (29)
Different Transcriptional Control of Metabolism and Extracellular Matrix in Visceral and Subcutaneous Fat of Obese and Rimonabant Treated Mice (2008) (29)
Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells (2006) (28)
Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets (2018) (28)
No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse. (2015) (27)
Sequence of the mouse liver glucose transporter. (1989) (26)
A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion (2016) (26)
GLP-1 protects β-cells against apoptosis by enhancing the activity of an IGF-2/IGF1-receptor autocrine loop (2009) (26)
cFLIP protein prevents tumor necrosis factor-alpha-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells. (2002) (25)
Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study (2021) (25)
Comparative effects of GLP-1-(7-36) amide, oxyntomodulin and glucagon on rabbit gastric parietal cell function. (1995) (24)
Recovery of Glucose-Induced Insulin Secretion in a Rat Model of NIDDM Is Not Accompanied by Return of the B-Cell GLUT2 Glucose Transporter (1992) (24)
Exendin-(9-39) Is an Inverse Agonist of the Murine Glucagon-Like Peptide-1 Receptor: Implications for Basal Intracellular Cyclic Adenosine 3',5'-Monophosphate Levels and β-Cell Glucose Competence* *This work was supported by Grant 31-46958.96 from the Swiss National Science Foundation (to B.T.). (1998) (23)
SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney (2018) (23)
The required beta cell research for improving treatment of type 2 diabetes (2013) (22)
Expression of an Uncleavable N-terminal RasGAP Fragment in Insulin-secreting Cells Increases Their Resistance toward Apoptotic Stimuli without Affecting Their Glucose-induced Insulin Secretion* (2005) (22)
Bioinformatics-Driven Identification and Examination of Candidate Genes for Non-Alcoholic Fatty Liver Disease (2011) (22)
Tetracycline-Regulated Expression of VEGF-A in Beta Cells Induces Angiogenesis: Improvement of Engraftment following Transplantation (2006) (21)
Signal transduction and desensitization of the glucagon-like peptide-1 receptor. (1996) (20)
Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes (2019) (19)
Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase (2016) (19)
Allogeneic β-islet cells correct diabetes and resist immune rejection (2002) (19)
Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction (2016) (18)
Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells. (2009) (18)
Distinct Classes of Central GLUT2-Dependent Sensors Control Counterregulation and Feeding (2006) (18)
Receptor-mediated phagocytosis by macrophages induces a calcium-dependent transient increase in c-fos transcription. (1989) (17)
Allogeneic beta-islet cells correct diabetes and resist immune rejection. (2002) (16)
Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation (2020) (16)
Clic4, a novel protein that sensitizes β-cells to apoptosisa (2015) (16)
Intracellular targeting of GLUT4 in transfected insulinoma cells: evidence for association with constitutively recycling vesicles distinct from synaptophysin and insulin vesicles. (1996) (16)
In vivo effect of murine recombinant interleukin 3 on early hemopoietic progenitors (1987) (15)
Expression of facilitative glucose transporter in rat liver and choroid plexus (1991) (14)
Physiology of GLP-1--lessons from glucoincretin receptor knockout mice. (2004) (14)
A toggle for type 2 diabetes? (2006) (13)
EuroDia: a beta-cell gene expression resource (2010) (13)
Fostering improved human islet research: a European perspective (2019) (12)
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study (2021) (11)
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans (2021) (11)
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis (2021) (11)
Peroxisome Proliferator-Activated Receptor-- Null Mice Have Increased White Adipose Tissue Glucose Utilization , GLUT 4 , and Fat Mass : Role in Liver and Brain (2006) (11)
Of fat, β cells, and diabetes. (2011) (11)
Title : The SLC 2 ( GLUT ) family of membrane transporters (10)
Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues (2020) (10)
Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice (2021) (9)
Leptin Inhibits Directly Glucocorticoid Secretion by Normal Human and Rat Adrenal Gland* * This work was supported by a grant from the Swiss National Science Foundation (No. 3100-050748.97/1). (1998) (9)
Destruction of conditional insulinoma cell lines in NOD mice: A role for autoimmunity (2003) (9)
Gluco-Incretins Regulate Beta-Cell Glucose Competence by Epigenetic Silencing of Fxyd3 Expression (2014) (9)
Expression of the NH2-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes (2009) (9)
The Hepatoportal Glucose Sensor (2004) (9)
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes (2020) (8)
GLP-1(9-36) mediates the glucagonostatic effect of GLP-1 by promiscuous activation of the glucagon receptor (2019) (7)
The SLC2 family of facilitated hexose and polyol transporters (2004) (7)
Klf6 protects β-cells against insulin resistance-induced dedifferentiation (2020) (7)
Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function (2022) (7)
Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine (2019) (7)
EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis (2020) (7)
Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption (2021) (7)
Mechanisms of glucose sensing and multiplicity of glucose sensors. (2004) (6)
The hyperstimulated β‐cell: prelude to diabetes? (2012) (6)
The facilitative glucose transporter 2: pathophysiological role in mouse and human (2003) (6)
Incretins: what is known, new and controversial in 2013? (2013) (5)
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes (2022) (5)
The GIuco-Incretin Hormone Glucagon-Like Peptide-1 and Its β-Cell Receptor (1994) (4)
Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow (2019) (4)
Regulated expression of GLUT2 in diabetes studied in transplanted pancreatic beta cells. (1994) (4)
Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse (2022) (4)
Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion (2022) (4)
Structure and Function of the Glucagon-Like Peptide-1 Receptor (1996) (4)
Pancreatic β-cell glucokinase, insulin secretion, and glucose homeostasis (1997) (4)
Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia (2021) (3)
A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion (2020) (3)
The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse (2020) (3)
GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis. (2018) (3)
Profound perturbation of the human metabolome by obesity (2018) (3)
Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion (2022) (3)
Neuronal regulation of glucagon secretion and gluconeogenesis (2022) (3)
PPAR b / d affects pancreatic b cell mass and insulin secretion in mice (2018) (3)
Defective glucose homeostasis in mice inactivated selectively for Tcf7l2 in the adult beta cell with an Ins1-controlled Cre (2014) (3)
[GLP-1 and the control of insulin secretion]. (1994) (2)
Involvement of 4E-BP1 in the Protection Induced by HDLs on Pancreatic β-Cells (2009) (2)
Engineering Tolerance into Transplanted β Cell Lines (2001) (2)
The mind and the belly: a glance at how the nervous system directs metabolism (2014) (2)
Promiscuous receptor activation mediates glucagonostatic effects of GLP-1(9-36) and GLP-1(7-36) (2019) (2)
[Gluco-incretin hormones in insulin secretion and diabetes]. (2003) (2)
The Islet and Metabolism Keep Time (2015) (2)
Development and preclinical assessment of a bioartificial pancreas. (2007) (2)
α-cell glucokinase suppresses glucose-regulated glucagon secretion (2018) (2)
Erratum: Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 (1997) (2)
GLUT2 expression by glial fibrillary acidic protein-positive tanycytes is required for promoting feeding-response to fasting (2022) (2)
Recent studies on the GLP-1 receptors (1993) (2)
A missing sugar prevents glucose entry: a new twist on insulin secretion. (2006) (2)
Replication and cross-validation of T2D subtypes based on clinical variables: an IMI-RHAPSODY study (2020) (2)
1 GLUCAGON-LIKE PEPTIDE-1 ( GLP-1 ) INCREASES BETA-CELL GLUCOSE COMPETENCE AND PROLIFERATION BY TRANSLATIONAL INDUCTION OF INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR ( IGF-1 R ) EXPRESSION (2010) (2)
Shifting the paradigm of islet inflammation—good guy or bad guy? (2013) (1)
Pathophysiology of Glut2 in Diabetes Mellitus (2001) (1)
Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse (2022) (1)
Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes (2023) (1)
SLC 2 A 9 ( GLUT 9 ) mediates urate reabsorption in the mouse kidney (2018) (1)
Physiological concentrations of GLP-1 increase insulin secretion by activating protein kinase C pathway in pancreatic beta cells (2012) (1)
Glucose-dependent insulinotropic polypeptide (GIP) receptor knock-out prevents ovariectomy-induced obesity in mice (2008) (1)
Correction: Gluco-Incretins Regulate Beta-Cell Glucose Competence by Epigenetic Silencing of Fxyd3 Expression (2014) (1)
In vivo and in vitro characterization of GL0034, a novel long‐acting glucagon‐like peptide‐1 receptor agonist (2022) (1)
Engineering tolerance into transplanted beta cell lines. (2001) (1)
[Gluco-incretin hormones in insulin secretion]. (2005) (1)
744-P: Effects of a Novel Long-Acting GIP/GLP-1/Glucagon Trireceptor Agonist, HISHS-3001, on HbA1c, Body Weight, and Lipid Metabolism (2022) (1)
Molecular biology of gluco-incretin function (2008) (1)
Expression of GS-coupled hormone receptors in rat pancreatic beta-cells (1995) (0)
Persistent or Transient Human β-Cell Dysfunction Induced by Metabolic Stress Associates with Specific Signatures and Shared Gene Expression of Type 2 Diabetes (2020) (0)
350-OR: A Novel Long-Acting GLP-1 Agonist (GL0034) Demonstrates Remarkable Efficacy on HbA1c, Weight Loss, and Triglycerides in a Model of Type 2 Diabetes, the db/db Mouse (2020) (0)
Central Glucose Sensing and Control of Food Intake and Energy Homeostasis (2011) (0)
IMPAIRED GLUCOSE SENSING AS INITIATOR OF METABOLIC DYSFUNCTIONS (2002) (0)
2440 1 H MRS TO INVESTIGATE THE HEPATIC PROFILE OF GLUT 2-/-MICE (2013) (0)
Optical interrogation of glucose-regulated beta cell connectivity (2014) (0)
[The entero-islet axis: role of the intestine and glycemic regulation]. (2006) (0)
[1996 Apollinaire Bouchardat Prize. Molecular aspects of control of insulin secretion]. (1996) (0)
GL0034, A novel long-acting glucagon-like peptide 1 receptor agonist exhibits significant efficacy in aged db/db mouse model of non-alcoholic fatty liver disease (NAFLD) (2022) (0)
ROLE OF GLUT2 IN GLUCOSE FLUXES AND BETA CELL GLUCOSE SENSING REVEALED GENE KNOCKOUT (1997) (0)
DEVELOPPEMENT D'UN PANCREAS BIOARTIFICIEL (1998) (0)
Correction: Peroxisomal and microsomal lipid pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state. (2020) (0)
Cell Metabolism Previews Of Fat , b Cells , and Diabetes (2011) (0)
Effects of GLP-1(9-36) and exendin-4 on glucagon secretion from human islets of Langerhans: evidence of a novel GLP-1 receptor in islets? (2014) (0)
1H MRS to investigate the hepatic profile of GLUT2-/- mice (2014) (0)
HomeostasisGlucose Sensing, Counterregulation, and Energy (2015) (0)
Exendin-4 Protects -Cells From Interleukin-1-Induced Apoptosis by Interfering With the c-Jun NH 2 -Terminal (2008) (0)
Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP (2010) (0)
A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production (2023) (0)
Homeostasis Brain Glucose Sensing , Counterregulation , and Energy (2007) (0)
SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney (2018) (0)
Original article EuroDia: a beta-cell gene expression resource (2010) (0)
[GIP and GLP-1: multiplicity of regulator mechanisms for insulin secretion]. (2004) (0)
Regulated expression of GLUT 2 in diabetes studied in transplanted pancreatic / 3 cells (2009) (0)
Resource Profound Perturbation of t he Metabolome in Obesity Is Associated with Health Risk Graphical (2019) (0)
GLUT2-/- mice are resistant to age-induced accumulation of fat in the liver – an in vivo MRS study (2012) (0)
Title The peroxisomal enzyme L-PBE is required to preventthe dietary toxicity of medium-chain Fatty acids (2017) (0)
MO076: GLUT2 as a Key Factor in the Pathogenesis of Diabetic Kidney Disease (2022) (0)
The transcriptome of persistent or transient human beta cell dys- function caused by lipo-glucotoxicity correlates with the gene expres- sion signature of type 2 diabetic islets (2019) (0)
Table of Contents (1995) (0)
Defects in glucose homeostasis in mice with genetic inactivation of the facilitated diffusion glucose transporter GLUT2 (2002) (0)
Targeting the Brain to Cure Type 2 Diabetes (2019) (0)
Perspectives in Diabetes Glucagon-Like Peptide-l and the Control of Insulin Secretion in the Normal State and in NIDDM (0)
EphrinB1 modulates glutamatergic inputs into POMC neurons and controls glucose homeostasis (2020) (0)
Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes" (2021) (0)
Glucagon receptor family in GtoPdb v.2021.3 (2021) (0)
638-P: A Novel, Long-Acting Dual Agonist for GIPR/GLP-1R, HISHS-2001, Demonstrates Effects on HbA1c and Weight Loss in the db/db Mouse Model of Type 2 Diabetes (2021) (0)
Hepatic glycogen metabolism in mice by in vivo 13 C MRS at 14 T (2010) (0)
Neurochemical profile of the mouse hypothalamus using 1 H MRS at 14 . 1 T (2008) (0)
A Single Dose of Oral Metformin Reduces the Post-Prandial Glucose Response Through a Transient Modulation of Apical Sodium-Glucose Co-Transporter (2019) (0)
Identification of biomarkers for glycaemic deterioration in type 2 diabetes (2023) (0)
Central glucose sensing and the control of energy homeostasis (2010) (0)
Out-immortalized cells for use in gene therapy (2000) (0)
sugar/polyol transport facilitators Nomenclature of the GLUT/SLC2A family of (2011) (0)
Partial gene deletion of endothelial NO synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension (2002) (0)
Sugar-Sensitive Hypothalamic Neurons Glucose-Induced Intracellular Ion Changes in (2015) (0)
High density lipoproteins protect pancreatic beta cells by targeting 4E-BP1 : 512 (2008) (0)
Role of Lipoproteins on Pancreatic Islet Cells Survival, Function and Proliferation (2020) (0)
Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia (2023) (0)
946-P: The GLP-1 Receptor Agonist GL0034 Activates Central Regions Controlling Glucose Homeostasis and Feeding Behavior (2020) (0)
Susumu Seino, MD, DMSci (1948–2021): A Pioneer in the Biology of Insulin Secretion (2022) (0)
Glucagon receptor family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (0)
Hypoglycemia activation of cerebral blood flow is mediated by glucose transporter isoform 2 : an in vivo CASL study (2013) (0)
Clinic al Implic a tions of Ba s ic R e se ar ch (2015) (0)
Studying effects of glucose transporter isoform 2 on brain metabolic activities using localized H-1 MRS and perfusion MRI (2013) (0)
Mike Mueckler (1953-2021) - the father of the mammalian SLC2 glucose transporter family. (2021) (0)
Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes. (2023) (0)
FXYD3, a New Regulator of Beta-Cell Glucose Competence That Is Developmentally Regulated by Gluco-Incretin Signalling through DNA Methylation (2011) (0)
Fasting-induced changes of hepatic lipid and carbohydrate stores in the absence of GLUT2 (2015) (0)
RETROVIRAL TRANSDUCTION OF PANCREATIC BETACELLS BY VEGF‐164 IMPROVES GLYCEMIC CONTROL IN A SYNGENEIC MODEL OF ISLET CELL TRANSPLANTATION: 0129 (2003) (0)
Alain Ktorza, PhD (2017) (0)
Mineral homeostasis and nephrolithiasis (2012) (0)
Metabolic studies of glucose transporter 2 knockout ( RIPGLUT 1 GLUT 2-/-) mice using in vivo 1 H MRS and CASL (2011) (0)

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What Schools Are Affiliated With Bernard Thorens?

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