Bernd Kaina

Bernd Kaina's AcademicInfluence.com Rankings

Bernd Kaina

Biology

#5643

World Rank

#8172

Historical Rank

Cell Biology

#255

World Rank

#263

Historical Rank

Molecular Biology

#677

World Rank

#694

Historical Rank

biology Degrees

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Biology

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According to Wikipedia, Bernd Kaina, born on 7 January 1950 in Drewitz, is a German biologist and toxicologist. His research is devoted to DNA damage and repair, DNA damage response, genotoxic signaling and cell death induced by carcinogenic DNA damaging insults.

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Bernd Kaina's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

DNA damage-induced cell death by apoptosis. (2006) (1376)
DNA damage and the balance between survival and death in cancer biology (2015) (778)
Rho GTPases are over‐expressed in human tumors (1999) (704)
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. (2013) (687)
Mechanisms of human DNA repair: an update. (2003) (637)
MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. (2007) (605)
From traditional Chinese medicine to rational cancer therapy. (2007) (478)
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine (2007) (452)
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters (2002) (372)
Cisplatin resistance: preclinical findings and clinical implications. (2010) (322)
O6‐methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells (2006) (290)
DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling. (2003) (283)
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron. (2004) (255)
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. (2000) (249)
Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. (1991) (237)
Survival and Death Strategies in Glioma Cells: Autophagy, Senescence and Apoptosis Triggered by a Single Type of Temozolomide-Induced DNA Damage (2013) (218)
Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation (2013) (212)
The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth. (2010) (208)
How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. (2009) (205)
O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry. (2011) (199)
Toxicity of the antimalarial artemisinin and its dervatives (2010) (199)
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models. (1997) (194)
Artesunate derived from traditional Chinese medicine induces DNA damage and repair. (2008) (189)
Rho GTPases: promising cellular targets for novel anticancer drugs. (2006) (189)
Variability and regulation of O6-alkylguanine-DNA alkyltransferase. (2003) (188)
Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. (2009) (185)
Regulation of repair of alkylation damage in mammalian genomes. (1993) (176)
DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability (2010) (167)
The Ras-related Small GTP-binding Protein RhoB Is Immediate-early Inducible by DNA Damaging Treatments (*) (1995) (160)
Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression (2010) (160)
Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments (1991) (153)
Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells. (2014) (153)
Toxicities by herbal medicines with emphasis to traditional Chinese medicine. (2011) (147)
Long‐term activation of SAPK/JNK, p38 kinase and fas‐L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance (2004) (147)
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. (1998) (146)
Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress (2011) (143)
Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. (1999) (143)
Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells. (2007) (143)
Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells (2011) (139)
p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents (1998) (137)
Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles (2010) (131)
DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326. (2001) (129)
Targeting O6-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy (2010) (128)
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes. (1996) (125)
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1 (2004) (124)
Lovastatin inhibits Rho‐regulated expression of E‐selectin by TNF‐α and attenuates tumor cell adhesion (2004) (124)
Phytochemistry and pharmacogenomics of natural products derived from traditional chinese medicine and chinese materia medica with activity against tumor cells (2008) (122)
DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts. (2001) (120)
Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation (2002) (120)
Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors. (2013) (119)
Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go (2004) (114)
Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents--a case of imbalanced DNA repair. (1995) (114)
DNA breaks and chromosomal aberrations arise when replication meets base excision repair (2014) (112)
Contribution of O6‐alkylguanine and N‐alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines (1993) (110)
DNA repair in resistance to alkylating anticancer drugs. (2002) (109)
Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation (2001) (108)
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs. (2009) (104)
Molecular biology of cantharidin in cancer cells (2007) (103)
Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. (2007) (103)
Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1 (1999) (103)
The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response. (2014) (103)
Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating Agents* (2000) (102)
MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome (2008) (102)
MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma (2010) (99)
Induction of heme oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment. (2000) (98)
Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling. (1998) (97)
Molecular modes of action of cantharidin in tumor cells. (2004) (96)
Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB. (2018) (94)
Survivin as a prognostic/predictive marker and molecular target in cancer therapy. (2012) (93)
APE/Ref-1 and the mammalian response to genotoxic stress. (2003) (93)
Rad51 and BRCA2 - New Molecular Targets for Sensitizing Glioma Cells to Alkylating Anticancer Drugs (2011) (93)
Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis. (1996) (92)
O6‐methylguanine‐DNA methyltransferase activity in breast and brain tumors (1995) (91)
Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53 (2009) (91)
Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents. (1990) (90)
DNA Double Strand Breaks as Predictor of Efficacy of the Alpha-Particle Emitter Ac-225 and the Electron Emitter Lu-177 for Somatostatin Receptor Targeted Radiotherapy (2014) (89)
Protective effect of O6‐methylguanine‐DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs (1996) (89)
Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells. (2002) (87)
BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. (2001) (87)
Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide (2006) (86)
Lovastatin Protects Human Endothelial Cells from Killing by Ionizing Radiation without Impairing Induction and Repair of DNA Double-Strand Breaks (2006) (86)
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity (2011) (86)
rhoB Encoding a UV-inducible Ras-related Small GTP-binding Protein Is Regulated by GTPases of the Rho Family and Independent of JNK, ERK, and p38 MAP Kinase* (1997) (85)
Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma. (2011) (84)
FEN1 is overexpressed in testis, lung and brain tumors. (2009) (84)
Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells (2001) (82)
Extent and Patterns of MGMT Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres (2010) (82)
Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism. (2003) (79)
c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation. (1995) (78)
Human CD4+CD25+ Regulatory T Cells Are Sensitive to Low Dose Cyclophosphamide: Implications for the Immune Response (2013) (78)
Contribution of ATM and ATR to the Resistance of Glioblastoma and Malignant Melanoma Cells to the Methylating Anticancer Drug Temozolomide (2013) (77)
Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB. (1999) (77)
A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs. (1997) (76)
Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O6-methylguanine due to high E2F1 regulated mismatch repair (2007) (75)
Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity. (2002) (73)
Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6‐methylguanine‐DNA methyltransferase and N‐methylpurine‐DNA glycosylase in melanoma cells with acquired drug resistance (1999) (72)
DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas. (2019) (72)
Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair (2014) (72)
Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance. (2016) (70)
Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate. (2010) (70)
Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling. (2003) (68)
Photochemical genotoxicity: principles and test methods. Report of a GUM task force. (2004) (67)
Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts. (2014) (66)
Enhanced survival and reduced mutation and aberration frequencies induced in V79 chinese hamster cells pre-exposed to low levels of methylating agents. (1982) (65)
O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer. (2013) (64)
Metallothionein expression in ovarian cancer in relation to histopathological parameters and molecular markers of prognosis (2001) (63)
Influence of DNA Repair on Nonlinear Dose-Responses for Mutation (2013) (62)
MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response (2016) (60)
Activity of O6‐methylguanine‐DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer (1999) (60)
Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells. (1992) (59)
Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis. (2000) (59)
Ras-related GTPase RhoB Represses NF-κB Signaling* (2001) (59)
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis (2010) (58)
PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression (2018) (58)
The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity. (2012) (57)
Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue. (1996) (57)
Activation of c-Jun N-Terminal Kinase 1 by UV Irradiation Is Inhibited by Wortmannin without Affecting c-jun Expression (1999) (57)
Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: correlation between chromosomal damage and conversion ('stage I of tumor promotion') in vivo. (1989) (57)
Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both. (2001) (56)
Ras-related GTPase RhoB forces alkylation-induced apoptotic cell death. (2000) (55)
Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: Implications for gene therapeutic approaches (2000) (53)
Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival. (2005) (52)
Rac1 Protein Signaling Is Required for DNA Damage Response Stimulated by Topoisomerase II Poisons* (2012) (52)
Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element. (2001) (51)
Kinetics of γ‐H2AX focus formation upon treatment of cells with UV light and alkylating agents (2008) (50)
Inhibition of O6-Methylguanine-DNA Methyltransferase by Glucose-Conjugated Inhibitors: Comparison with Nonconjugated Inhibitors and Effect on Fotemustine and Temozolomide-Induced Cell Death (2004) (50)
Human Monocytes Undergo Excessive Apoptosis following Temozolomide Activating the ATM/ATR Pathway While Dendritic Cells and Macrophages Are Resistant (2012) (50)
Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents. (1998) (49)
Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents. (1997) (49)
Glutathione, GlutathioneS-Transferase α and π, and Aldehyde Dehydrogenase Content in Relationship to Drug Resistance in Ovarian Cancer (1997) (48)
A role for UV-light-induced c-Fos: Stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis. (2007) (48)
Nutrition in adult and childhood cancer: role of carcinogens and anti-carcinogens. (2012) (47)
Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition and Chk/p53 signaling. (2008) (47)
O6‐methylguanine‐DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts (1998) (47)
Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability. (1996) (47)
The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea. (1997) (47)
Epigenetic regulation of DNA repair genes and implications for tumor therapy. (2017) (46)
Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents. (2007) (46)
Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir. (2002) (46)
Critical steps in alkylation-induced aberration formation. (1998) (46)
Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage (2010) (46)
The Translesion Polymerase Rev3L in the Tolerance of Alkylating Anticancer Drugs (2009) (45)
c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF (2006) (44)
Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing. (2015) (44)
Local intracerebral administration of O6-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma (2007) (43)
Rho GTPases Are Involved in the Regulation of NF-κB by Genotoxic Stress (2001) (43)
Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling. (2017) (42)
O(6)-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke. (2012) (42)
Lovastatin causes sensitization of HeLa cells to ionizing radiation‐induced apoptosis by the abrogation of G2 blockage (2003) (42)
The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage (2015) (42)
Fen1 is induced p53 dependently and involved in the recovery from UV-light-induced replication inhibition (2005) (41)
Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance. (2014) (41)
DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage. (2001) (40)
Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms. (1998) (40)
Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM (2015) (40)
Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent (2000) (39)
Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans (2017) (39)
Mechanisms of the ultraviolet light response in mammalian cells. (1989) (39)
Nuclear expression of apurinic/apyrimidinic endonuclease increases with progression of ovarian carcinomas. (2004) (39)
Comparison of DNA repair and radiosensitivity of different blood cell populations (2021) (38)
Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation. (1995) (38)
Stress factors affecting expression of O6-methylguanine-DNA methyltransferase mRNA in rat hepatoma cells. (1992) (38)
Deficiency in DNA polymerase beta provokes replication-dependent apoptosis via DNA breakage, Bcl-2 decline and caspase-3/9 activation. (2002) (38)
Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations. (2004) (37)
Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model (2013) (37)
AhR-mediated changes in global gene expression in rat liver progenitor cells (2013) (37)
Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy. (2014) (37)
An Update of the Mammalian UV Response: Gene Regulation and Induction of a Protective Function (1989) (36)
The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death (2019) (36)
Dependency of the yield of sister-chromatid exchanges induced by alkylating agents on fixation time. Possible involvement of secondary lesions in sister-chromatid exchange induction. (1985) (36)
Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response (2018) (36)
Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs (2016) (36)
Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations (2016) (36)
Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid. (2004) (36)
Long-time expression of DNA repair enzymes MGMT and APE in human peripheral blood mononuclear cells (2001) (36)
Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response. (2009) (36)
Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. (2001) (36)
Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide? (2019) (35)
DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. (2015) (35)
DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors. (2003) (35)
Topotecan Triggers Apoptosis in p53-Deficient Cells by Forcing Degradation of XIAP and Survivin Thereby Activating Caspase-3-Mediated Bid Cleavage (2010) (35)
Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence (2016) (34)
Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging (2013) (34)
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. (2015) (34)
Temozolomide Dosing Regimens for Glioma Patients (2012) (33)
Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair (2016) (32)
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors (2011) (32)
Cross-resistance studies with V79 Chinese hamster cells adapted to the mutagenic or clastogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine. (1983) (32)
Glutathione, glutathione S-transferase alpha and pi, and aldehyde dehydrogenase content in relationship to drug resistance in ovarian cancer. (1997) (31)
Theoretical considerations for thresholds in chemical carcinogenesis. (2015) (31)
Studies on adaptation of V79 Chinese hamster cells to low doses of methylating agents. (1983) (31)
The interrelationship between SCE induction, cell survival, mutagenesis, aberration formation and DNA synthesis inhibition in V79 cells treated with N-methyl-N-nitrosourea or N-methyl-N'-nitro-N-nitrosoguanidine. (1985) (30)
Biodosimetry Based on γ-H2AX Quantification and Cytogenetics after Partial- and Total-Body Irradiation during Fractionated Radiotherapy (2015) (30)
p53 Mutant Human Glioma Cells Are Sensitive to UV-C-Induced Apoptosis Due to Impaired Cyclobutane Pyrimidine Dimer Removal (2009) (30)
Inactivation of O6‐methylguanine‐DNA methyltransferase by glucose‐conjugated inhibitors (2001) (30)
Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide. (2006) (30)
The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells (2015) (30)
Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens. (2017) (30)
AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells (2017) (30)
Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil (2015) (30)
Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug β-D-glucosyl-ifosfamide mustard (2002) (29)
Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid. (2011) (29)
Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB. (2005) (29)
Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir. (2000) (29)
Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair. (2001) (27)
Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts. (2013) (26)
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation. (2008) (26)
Genotoxicity testing: Comparison of the γH2AX focus assay with the alkaline and neutral comet assays. (2017) (26)
XRCC3 contributes to temozolomide resistance of glioblastoma cells by promoting DNA double-strand break repair. (2018) (26)
Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity (2010) (26)
The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation (2017) (26)
Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging. (2006) (25)
Rho GTPases are involved in the regulation of NF-kappaB by genotoxic stress. (2001) (25)
Inhibition of protein isoprenylation impairs rho-regulated early cellular response to genotoxic stress. (2000) (25)
The action of N-methyl-N-nitrosourea on non-established human cell lines in vitro. I. Cell cycle inhibition and aberration induction in diploid and Down's fibroblasts. (1977) (25)
Repair gene O6‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation (2018) (24)
Rechallenge with temozolomide with different scheduling is effective in recurrent malignant gliomas. (2008) (24)
The γH2AX DNA damage assay from a drop of blood (2016) (24)
Degradation of heterocyclic aromatic amines in oil under storage and frying conditions and reduction of their mutagenic potential. (2007) (24)
The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide. (2002) (23)
Ras-related GTPase Rhob represses NF-kappaB signaling. (2001) (23)
Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells. (2006) (23)
Overexpression of c-fos increases recombination frequency in human osteosarcoma cells. (1993) (23)
Involvement of fos in spontaneous and ultraviolet light‐induced genetic changes (1991) (23)
Infrequent promoter methylation of the MGMT gene in liver metastases from uveal melanoma (2008) (22)
ERCC1 and XPF expression in human testicular germ cell tumors. (2009) (22)
Chloroethylnitrosourea-induced cell death and genotoxicity: Cell cycle dependence and the role of DNA double-strand breaks, HR and NHEJ (2012) (22)
Nickel(II) inhibits the repair of O6-methylguanine in mammalian cells (1998) (22)
DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP (2016) (22)
Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related. (2003) (22)
Change in expression of MGMT during maturation of human monocytes into dendritic cells. (2007) (21)
Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells (1987) (21)
Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. (2013) (21)
DNA repair protein O6-methylguanine-DNA methyltransferase in testis and testicular tumors as determined by a novel nonradioactive assay. (2003) (20)
DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK). (2009) (20)
Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells* (2011) (20)
B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells (2014) (20)
Cell and tissue-type specific expression of Ras-related GTPase RhoB. (1999) (20)
Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells (2017) (20)
Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins. (2001) (19)
Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69 (2019) (19)
Role of transporter genes in cisplatin resistance. (2008) (19)
Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin. (2003) (19)
Molecular determinants of response of tumor cells to berberine (2005) (19)
Apoptosis in UV-C light irradiated p53 wild-type, apaf-1 and p53 knockout mouse embryonic fibroblasts: Interplay of receptor and mitochondrial pathway (2005) (19)
Chromosomal aberrations as a contributing factor for tumor promotion in the mouse skin. (1989) (18)
Nijmegen Breakage Syndrome Protein (NBN) Causes Resistance to Methylating Anticancer Drugs Such as Temozolomide (2010) (18)
Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors. (2015) (18)
The action of N-methyl-N-nitrosourea on non-established human cell lines in vitro. II. Non-random distribution of chromatid aberrations in diploid and Down's cells. (1977) (17)
Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. (2003) (17)
DNA repair and chromosomal stability in the alkylating agent-hypersensitive Chinese hamster cell line 27-1. (1990) (17)
Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors. (2015) (16)
Synthesis of 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-β-d-glucosyl)-purine: a novel radioligand for positron emission tomography studies of the O6-methylguanine-DNA methyltransferase (MGMT) status of tumour tissue (2002) (16)
Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex-. (1992) (16)
Microarray-based Prediction of Cytotoxicity of Tumor Cells to Arsenic Trioxide. (2004) (16)
Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence (2020) (16)
Rac1 GTPase, a multifunctional player in the regulation of genotoxic stress response (2013) (16)
On the Origin of SARS-CoV-2: Did Cell Culture Experiments Lead to Increased Virulence of the Progenitor Virus for Humans? (2021) (15)
Hamster Bcl-2 protein is cleaved in vitro and in cells by caspase-9 and caspase-3. (2001) (15)
High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines. (1997) (15)
Modulation of Base Excision Repair Alters Cellular Sensitivity to UVA1 but not to UVB¶ (2002) (15)
The impact of the IGF-1 system of cancer cells on radiation response – An in vitro study (2017) (14)
Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death (2013) (14)
Isolation and analysis of inducibility of the rat N-methylpurine-DNA glycosylase promoter. (1996) (13)
Compromised DNA Repair and Signalling in Human Granulocytes (2018) (13)
O6-methylguanine, but not N7-methylguanine or N3-methyladenine, induces gene mutations, sister-chromatid exchanges and chromosomal aberrations in Chinese hamster cells. (1983) (13)
Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance (2016) (13)
Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases (2017) (13)
Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms. (2005) (13)
Lovastatin stimulates p75 TNF receptor (TNFR2) expression in primary human endothelial cells. (2005) (12)
The Wound Response as a Key Element for an Understanding of Multistage Carcinogenesis in Skin (1988) (12)
Safety and Efficacy of Methylene Blue-Aided Chromoendoscopy in Ulcerative Colitis: A Prospective Pilot Study Upon Previous Chromoendoscopies (2004) (12)
Epigenetic silencing of XAF1 in high-grade gliomas is associated with IDH1 status and improved clinical outcome (2017) (12)
Does increase in DNA repair allow “Tolerance‐to‐Insult” in chemical carcinogenesis? Skin tumor experiments with MGMT‐overexpressing mice (2014) (12)
Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy. (2018) (12)
Human primary endothelial cells are impaired in nucleotide excision repair and sensitive to benzo[a]pyrene compared with smooth muscle cells and pericytes (2019) (11)
Cytotoxic, Genotoxic and Senolytic Potential of Native and Micellar Curcumin (2021) (11)
Generation and characterization of tTS‐H4: a novel transcriptional repressor that is compatible with the reverse tetracycline‐controlled TET‐ON system (2007) (11)
Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment (2021) (11)
Correction of alkylation hypersensitivity of CHO-W27-1 cells by transfection with human DNA. (1987) (10)
Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo (2018) (10)
Response of pancreatic cancer cells treated with interferon-α or β and co-exposed to ionising radiation (2010) (10)
Targeting of O6-methylguanine-DNA methyltransferase (MGMT) activity by antimessenger oligonucleotide sensitizes CHO/Mex+ transfected cells to mitozolomide. (1996) (10)
Mutagenic and genotoxic effects of O6-methylguanine: a revision. (1984) (10)
Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains. (1993) (10)
Microarray-based expression of DNA repair genes does not correlate with growth inhibition of cancer cells by natural products derived from traditional Chinese medicine. (2008) (10)
Transcriptional and epigenetic regulation of DNA repair (2017) (10)
Effect of transfection of human poly(ADP-ribose)polymerase in Chinese hamster cells on mutagen resistance. (1994) (9)
Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses (2021) (9)
Curcumin Administered as Micellar Solution Suppresses Intestinal Inflammation and Colorectal Carcinogenesis (2020) (9)
Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells (2022) (8)
Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells. (2004) (8)
Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells (2020) (8)
The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells. (2012) (8)
An approach to the evaluation of the activity of the DNA repair enzyme O6-methylguanine-DNA-methyl-transferase in tumor tissue in vivo: syntheses of 6-benzyloxy-9-(2-[18F]fluoroethyl)-9H-purin-2-yl-amine and 6-benzyloxy-7-(2-[18F]fluoroethyl)-7H-purin-2-yl-amine. (2002) (7)
Transfer of Genes Affecting Resistance of Mammalian Cells to Alkylating Drugs — Implications for Cancer Chemotherapy (1995) (7)
Induction of fos and jun mRNA by alkylating agents in cells proficient and deficient for O6-methylguanine-DNA methyltransferase (1996) (7)
Identification of human genes involved in repair and tolerance of DNA damage (1991) (7)
Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress (2006) (7)
MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck. (2010) (7)
Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline. (2005) (7)
DNA Methylation Damage: Formation, Repair and Biological Consequences (2007) (6)
Impaired DNA repair in mouse monocytes compared to macrophages and precursors. (2020) (6)
Overexpression of cDNA encoding FANCC, SPHAR, MPG, SNM1 or HA 3611 does not render CHO cells more resistant to DNA crosslinking agents. (1999) (6)
DNA damage in lymphocytes of patients suffering from complex traumatization. (2017) (6)
In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice (2009) (6)
Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo (2021) (6)
Analysis of the Vicia faba genome by use of restriction endonucleases. (1979) (6)
Genotoxic and cytotoxic potential of methacrylate-based orthodontic adhesives (2020) (6)
Quantification of Radiation Biomarkers in Leukocytes of Breast Cancer Patients Treated with Different Modalities of 3D-CRT or IMRT (2016) (6)
Tegwondo: Development of a novel near-continuous dose-dense temozolomide regimen for the treatment of recurrent brain tumors (2008) (6)
Detection of O6-methylguanine-DNA methyltransferase-expression in human tumors by means of in situ hybridization. (1995) (5)
Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent (2020) (5)
The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity. (2015) (5)
[Methylphenidate-induced cytogenetic alterations?]. (2006) (5)
On time dependency of frequency and distribution of chromatid aberrations induced by mutagens with delayed effects. An interpretation. (1981) (4)
Genetic and cytogenetic effects of 1,3-dimethyl-3-phenyl-1-nitrosourea in Salmonella typhimurium and Chinese hamster V79 cells. (1983) (4)
MGMT—a critical DNA repair gene target for chemotherapy resistance (2016) (4)
Inducible Responses and Protective Functions of Mammalian Cells Upon Exposure to UV Light and Ionizing Radiation (1999) (4)
Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics (2022) (4)
FEN 1 is Overexpressed in Testis , Lung and Brain Tumors (2009) (4)
Accumulation of Temozolomide-Induced Apoptosis, Senescence and DNA Damage by Metronomic Dose Schedule: A Proof-of-Principle Study with Glioblastoma Cells (2021) (4)
Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis. (2019) (4)
Corrigendum to "DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas" [DNA Repair 78 (2019) 128-141]. (2019) (3)
Synthetic Strategies Towards O6-Substituted Guanine Derivatives and Their Application in Medicine (2005) (3)
Cloning and functional analysis of cDNA encoding the hamster Bcl-2 protein. (2000) (3)
Organization of 5 S RNA genes in vicia faba (1978) (3)
Complementation of N-hydroxyethyl-N-chloroethylnitrosourea hypersensitivity of Mex- cells by microinjection of mRNA from Mex+ cells. (1990) (3)
Temozolomide – Just a Radiosensitizer? (2022) (3)
Inhibition of O-Methylguanine-DNA Methyltransferase by Glucose-Conjugated Inhibitors: Comparison with Nonconjugated Inhibitors and Effect on Fotemustine and Temozolomide-Induced Cell Death (2004) (3)
INDUCIBLE PROTECTIVE FUNCTIONS OF MAMMALIAN CELLS AGAINST DNA DAMAGING AGENTS (1998) (3)
Evolution of DNA Repair Mechanisms (2002) (2)
Dose–response of alkylation-induced colorectal carcinogenesis in MGMT-proficient and -deficient mice (2013) (2)
Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil (2014) (2)
Synthesis of 2‐Amino‐6‐(2‐ [18F] fluoro‐pyridine‐4‐ylmethoxy)‐9‐(octyl‐β‐D‐glucosyl)‐purine: A Novel Radioligand for Positron Emission Tomography Studies of the O6‐Methylguanine‐DNA Methyltransferase (MGMT) Status of Tumor Tissue. (2002) (2)
DNA repair in defence against genotoxin-induced apoptosis (2006) (2)
A genome-wide screening for DNA repair genes: much more players than hitherto known (2020) (2)
Toxic and clastogenic effects of the polyfunctional alkylating agent N,N,N′-tri(β-chloroethyl)-N′-(p-formylphenyl)-propylenediamine in the presence and absence of sodium borohydride in V79 Chinese hamster cells (1981) (1)
GENOMIC AND ENVIRONMENTAL INFLUENCES ON MUTAGEN-INDUCED RECOMBINATION IN PLANT CHROMOSOMES (1980) (1)
Apoptosis Induced by DNA‐damaging Agents (2008) (1)
Die Aktivität des DNA-Reparaturenzyms O6-Methyl-DNA-Methyltransferase beim Ovarialkarzinom (2002) (1)
Expression of a cytokeratin-promoter driven human MGMT repair gene in transgenic mice (1996) (1)
Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells (2016) (1)
DNA Damaging Drugs in the Treatment of Glioblastoma: HR, Apoptosis, Autophagy and Senescence (2012) (1)
ERCC 1 and XPF expression in human testicular germ cell tumors (1)
On the 50th anniversary of the elucidation of the DNA structure. (2003) (1)
Therapeutics , Targets , and Chemical Biology Translesion Polymerase h Is Upregulated by Cancer Therapeutics and Confers Anticancer Drug Resistance (2014) (1)
DNA Damage Response and the Balance Between Cell Survival and Cell Death (2010) (1)
METALLOTHIONEI NEXPRESSIO NI NOVARIA NCANCE RI NRELATIO NTO HISTOPATHOLOGICA LPARAMETER SAN DMOLECULA RMARKER SOF PROGNOSIS (2001) (0)
DNA double strand break assessment by yH2AX-foci quantification after alpha-particle emitter Ac-225 and electron emitter Lu-177 somatostatin receptor targeted radiotherapy correlates with cell death and apoptosis in vitro (2013) (0)
Do carcinogens have a threshold dose? Pro and contra (2015) (0)
Sensitivity of CD3/CD28-stimulated versus non-stimulated lymphocytes to ionizing radiation and genotoxic anticancer drugs: key role of ATM in the differential radiation response (2018) (0)
Do Carcinogens Have a Threshold Dose? The Pros and Cons (2021) (0)
Contents Vol. 104, 2004 (2004) (0)
A transgenic non-human mammal, containing an additional DNA repair (1996) (0)
Adaptation of V79 Chinese hamster cells to low doses of monofunctional alkylating agents (1982) (0)
O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy (2013) (0)
Interplay of DNA repair and damage signaling in genotoxin-induced apoptosis and necrosis (2009) (0)
KRAS-mutated iCCA display distinct molecular alterations and a preferential sensitivity towards PARP-1 inhibition (2021) (0)
Induction of genetic damage and apoptosis by ganciclovir in Chinese hamster ovary cells transfected with the thymidine kinase (tk) gene of HSV-1 (1997) (0)
Influence of MAPK-signaling on the temozolomide and nimustine induced apoptosis in glioma cells (2016) (0)
In vitro evaluation of alpha-particle emitter Ac-225 for somatostatin receptor radiotherapy (2012) (0)
Chemotherapy Sensitizing Effects of Methadone in Glioblastoma Cells Are Drug- and Cell Line-dependent (2020) (0)
biomedical research Of mice and models: improved animal models for (2015) (0)
P IV.10 Stable yeast but not human apurinic/apyrimidinic en-donuclease transfectants of Chinese hamster cells are more resistant to genotoxic agents (1997) (0)
Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death (2013) (0)
C-mediated Signaling-Methylguanine-DNA Methyltransferase via Protein Kinase 6 O Regulation of Expression of the DNA Repair Gene Updated (2006) (0)
Plasmid for the production of sense and antisense RNA samples of human MGMT gene (1993) (0)
Toxic and clastogenic effects of the polyfunctional alkylating agent N,N,N'-tri(beta-chloroethyl)-N'-(p-formylphenyl)-propylenediamine 1,3 (TFP) in the presence and absence of sodium borohydride in V79 Chinese hamster cells. (1981) (0)
P25 21 WP – EXPRESSION OF THE HUMAN O6-METHYLGUANINE-DNA METHYLTRANSFERASE GENE IN CHINESE HAMSTER CELLS PROTECTS THEM FROM GRNOTOXIC EFFECTS OF ALKYLATING AGENTS (1991) (0)
Past, present and future of immunology in Mainz. (2016) (0)
Mammifere transgenique non humain qui contient un gene reparateur d'adn additionnel (1997) (0)
Is there a Genotoxic Potential of Endodontic Root Materials? (2017) (0)
Gamma-H2AX: A Sensitive Biodosimeter in Radiation Therapy? (2014) (0)
Book reviews (2004) (0)
Is MGMT inducible in malignant glioma cells (2013) (0)
Inducibility oftheDNA Repair GeneEncoding 06-Methylguanine- (1991) (0)
Artesunate in glioblastoma therapy (2015) (0)
Transgenic Chinese hamster ovary (CHO) cells expressing the yeast apurinic/apyrimidinic endonuclease gene (APN1) are more resistant to DNA damaging agents (1997) (0)
Dose response to methylating agents in the γH2AX, SCE and colony formation assays: Effect of MGMT and MPG overexpression. (2022) (0)
Temporal and mechanistic studies on the resistance of glioma cells to temozolomide (2016) (0)
Site-specific mutagenesis. Results, problems and perspectives. (1980) (0)
Temozolomide induced autophagy stimulates senescence and inhibits apoptosis in glioma cells (2013) (0)
Contribution ENHANCEMENT OF CYTOTOXICITY OF ARTEMISININS TOWARD CANCER CELLS (2004) (0)
DNA Repair and Damage Response Following Exposure of Cells to Alkylating Carcinogens (2012) (0)
Preferential effect of PARP-1 inhibition in KRAS-mutated intrahepatic cholangiocarcinomas is mediated by CHK1/2 kinases (2023) (0)
Survival and Death Strategies in Cells Exposed to Genotoxins (2012) (0)
Pharmacogenomics of Biotic and Abiotic Natural Products Derived from Traditional Chinese Medicine for Cancer Therapy (2009) (0)
Abstract B63: Targeting cancer cells with a glucose-conjugated DNA repair inhibitor. (2011) (0)
MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response (2016) (0)
Abscopal Effect and Drug-Induced Xenogenization: A Strategic Alliance in Cancer Treatment? (2021) (0)
Pilot Study on Malnutrition and DNA Damage in Patients with Newly Diagnosed Gastrointestinal Tumors: Is DNA Damage Reversible by Early Individualized Nutritional Support? (2020) (0)
Expression of O6-methylguanine-DNA methyltransferase in human tumors (1996) (0)
Carcinogens and Cytostatic Drugs (1997) (0)
and c-kit-expressing lineage-negative hematopoietic cells conditional expression to erythrocytes, megakaryocytes, granulocytes, Tetracycline-controlled transgenic targeting from the SCL locus directs (2011) (0)
460. MGMTP140K Vector Constructs for Efficient In Vivo Enrichment of Genetically Corrected Cells Following Hematopoietic Cell Gene Transfer (2006) (0)
Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases (2017) (0)
Transfection and expression of human N-methylpurine-DNA glycosylase (MPG) in Chinese hamster ovary cells: Effect on cell killing, mutation, SCE and aberration induction by methylating agents (1996) (0)
Radiation sensitivity, DNA repair and death regulation of immunocompetent cellss (2022) (0)
c-Fos/AP-1 dependent regulation of the three prime exonuclease 1 (TREX1) by genotoxic stress (2009) (0)
Modulation of Base Excision Repair Alters Cellular Sensitivity to UVA1 but not to UVB ¶ (2002) (0)
AhR-mediated changes in global gene expression in rat liver progenitor cells (2012) (0)
Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo (2018) (0)
DNA double strand break assessment as predictor of efficacy of the alpha-particle emitter Ac-225 and the electron emitter Lu-177 for somatostatin receptor radiotherapy (2013) (0)
PO-210 Anticancer drug-induced senescence in glioblastoma cells is associated with changes in DNA repair capacity (2018) (0)
DNA repair systems (2006) (0)
Mutagenicity of Selected Chemicals in Vicia Faba and Allium Cepa Test Systems (1981) (0)
The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage (2014) (0)
Tegwondo – development of a novel near-continuous dose-dense temozolomide regimen for the treatment of recurrent gliomas (2008) (0)
Gene expression of 3R in breast tumors from the CAPS01 protocol (2009) (0)
The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation (2016) (0)

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