Bernhard. Witkop

Bernhard. Witkop's AcademicInfluence.com Rankings

Bernhard. Witkop

Chemistry

#1025

World Rank

#1638

Historical Rank

Organic Chemistry

#109

World Rank

#145

Historical Rank

chemistry Degrees

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Chemistry

Bernhard. Witkop's Degrees

PhD Chemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Bernhard. Witkop's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Nonenzymatic cleavage of peptide bonds: the methionine residues in bovine pancreatic ribonuclease. (1962) (662)
Hydroxylation-induced migration: the NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds. (1967) (443)
[58] Determination of the tryptophan content of proteins with N-bromosuccinimide (1967) (432)
1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. (1970) (395)
A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine. (1960) (354)
SELECTIVE CLEAVAGE OF THE METHIONYL PEPTIDE BONDS IN RIBONUCLEASE WITH CYANOGEN BROMIDE1 (1961) (349)
GRAMICIDIN A. V. THE STRUCTURE OF VALINE- AND ISOLEUCINE-GRAMICIDIN A. (1965) (308)
Role of the arene oxide-oxepin system in the metabolism of aromatic substrates: I. In vitro conversion of benzene oxide to a premercapturic acid and a dihydrodiol (1968) (214)
The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. 3. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes. (1968) (195)
Batrachotoxin: Chemistry and Pharmacology (1971) (182)
O-Methylation of catechol amines in vivo. (1958) (173)
Substrates and inhibitors of dopamine-β-oxidase (1962) (164)
Nonenzymatic methods for the preferential and selective cleavage and modification of proteins. (1961) (149)
Chemical, Enzymatic and Metabolic Studies on the Mechanism of Oxidation of Dopamine1 (1959) (146)
Anatoxin-a: a novel, potent agonist at the nicotinic receptor. (1980) (134)
SELECTIVE CLEAVAGE OF PEPTIDE BONDS. II. THE TRYPTOPHYL PEPTIDE BOND AND THE CLEAVAGE OF GLUCAGON1 (1958) (131)
Histrionicotoxins: roentgen-ray analysis of the novel allenic and acetylenie spiroalkaloids isolated from a Colombian frog, Dendrobates histrionicus. (1971) (122)
The structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, Phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs. (1969) (116)
Selective cleavage and modification of peptides and proteins. (1970) (115)
The Use of N-Bromosuccinimide and N-Bromoacetamide for the Selective Cleavage of C-Tryptophyl Peptide Bonds in Model Peptides and Glucagon1 (1960) (112)
Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions. (1973) (106)
O-methylation, the principal pathway for the metabolism of epinephrine and norepinephrine in the rat. (1958) (102)
Gephyrotoxins, histrionicotoxins and pumiliotoxins from the neotropical frog Dendrobates histrionicus. (1977) (99)
Dynamic aspects of enzymatic O-methylation and -demethylation of catechols in vitro and in vivo. (1960) (99)
The combined use of α-methyltyrosine and threo-dihydroxyphenylserine—selective reduction of dopamine levels in the central nervous system (1968) (99)
Studies on Hydroxyproline (1957) (98)
Imine-Enamine Systems and the Mechanism of their Oxidation1 (1956) (98)
Gramicidin. VIII. The Structure of Valine- and Isoleucine-Gramicidin C* (1965) (93)
Anatoxin-a interactions with cholinergic synaptic molecules. (1981) (92)
The reactivity toward N-bromosuccinimide of tryptophan in enzymes, zymogens, and inhibited enzymes. (1966) (91)
[30] N-Bromosuccinimide cleavage of peptides (1967) (91)
Ring Effects in Autoxidation. A New Type of Camps Reaction1,2 (1951) (90)
Photoreductions and photocyclizations of tryptophan. (1966) (88)
Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds (1972) (87)
Non-enzymatic Conversions of Dopamine to Norepinephrine and Trihydroxyphenethylamines1 (1959) (84)
Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor. (1977) (83)
Enzymatic p-O-Methylation by Catechol O-Methyl Transferase (1959) (82)
A valid model for the mechanism of oxidation of tryptophan to formylkynurenine-25 years later. (1977) (80)
Quinol Intermediates in the Oxidation of Phenols and Their Rearrangements1 (1957) (78)
Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane. (1980) (77)
Comparative binding studies with cholinergic ligands and histrionicotoxin at muscarinic receptors of neural cell lines. (1978) (75)
Nuclear Magnetic Resonance Spectra of Indoles (1960) (71)
GRAMICIDIN. VII. THE STRUCTURE OF VALINE- AND ISOLEUCINE-GRAMICIDIN B. (1965) (71)
Analogs and Homologs of Proline and Hydroxyproline (1966) (69)
The chemorelease of norepinephrine from mouse hearts. Structure-activity relationships. I. Sympathomimetic and related amines. (1966) (67)
Allenic and acetylenic spiropiperidine alkaloids from the neotropical frog, Dendrobates histrionicus. (1974) (67)
Addition Reactions and Wagner-Meerwein Rearrangements in the Indoxyl Series (1951) (66)
Batrachotoxin. The active principle of the Colombian arrow poison frog, Phyllobates bicolor. (1965) (66)
The effects of selected nitrogen compounds on the growth of plant tissue cultures. (1958) (66)
Incorporation of cis- and trans-4-Fluoro-L-prolines into Proteins and Hydroxylation of the trans Isomer During Collagen Biosynthesis* (1965) (66)
The structure of batrachotoxinin A, a novel steroidal alkaloid from the Colombian arrow poison frog, Phyllobates aurotaenia. (1968) (64)
The Course and Kinetics of the Acid-Base-Catalyzed Rearrangements of 11-Hydroxytetrahydrocarbazolenine1 (1951) (63)
Selective Cleavage of C-Tryptophyl Peptide Bonds in Proteins and Peptides (1959) (62)
The Preparation of cis- and trans-4-H3-L-Prolines and Their Use in Studying the Mechanism of Enzymatic Hydroxylation in Chick Embryos (1964) (61)
GRAMICIDIN A. VI. THE SYNTHESIS OF VALINE- AND ISOLEUCINE-GRAMICIDIN A. (1965) (60)
Total Synthesis and Electrophysiological Properties of Natural (−)‐Perhydrohistrionicotoxin, its Unnatural (+)‐Antipode and their 2‐Depentyl Analogs (1982) (59)
Paul Ehrlich and his Magic bullets--revisited. (1999) (59)
Acetylcholine receptor and ionic channel of Torpedo electroplax: binding of perhydrohistrionicotoxin to membrane and solubilized preparations. (1978) (58)
Substitution, Oxidation and Group Participation in the Bromination of Indoles (1960) (58)
Gramicidin A. IV. Primary Sequence of Valine and Isoleucine Gramicidin A (1964) (58)
Gramicidin. IX. Preparation of Gramicidin A, B, and C* (1965) (57)
Enzymatic conversion of 5-tritiotryptophan to 4-tritio-5-hydroxytryptophan (1966) (57)
Synthetic polypeptides as substrates and inhibitors of collagen proline hydroxylase. (1968) (56)
Conformations of the li-antamanide complex and na-[phe, val]antamanide complex in the crystalline state. (1973) (55)
Cyclization of tryptophan and tryptamine derivatives to 2,3-dihydropyrrolo[2,3-b]indoles. (1970) (55)
Formation and Rearrangements of Aminochromes from a New Metabolite of Dopamine and Some of its Derivatives1 (1959) (55)
The Oxidative Cleavage of Tyrosyl-Peptide Bonds. I. Cleavage of Dipeptides and Some Properties of the Resulting Spirodienone-lactones (1959) (55)
Hydroxylation of alkyl and halogen substituted anilines and acetanilides by microsomal hydroxylases. (1968) (53)
The Structure of the So-called 11-Hydroxytetrahydrocarbazolenine1 (1950) (52)
Isolation, Configuration, and Synthesis of Natural cis- and trans-3-Hydroxyprolines (1963) (52)
Transannular Reactions of Peptides. The Peptide Nitrogen in a 10-Membered Ring1,2 (1955) (51)
Fischer Indole Syntheses with Polyphosphoric Acid (1952) (51)
On the Mechanism of Oxidation. I. A New Type of Peroxide Rearrangement Catalyzed by Acid (1951) (51)
Effects of histrionicotoxin on the chemosensitive and electrical properties of skeletal muscle (1975) (50)
Effect of Cytosine Arabinoside, lododeoxyuridine, Ethyldeoxyuridine, Thiocyanatodeoxyuridine, and Ribavirin on Tail Lesion Formation in Mice Infected with Vaccinia Virus (1976) (50)
The Synthesis of Labile Hydroxytryptophan Metabolites1 (1954) (50)
Synthesis and x-ray analysis of cis-3,4-methylene-L-proline, the new natural amino acid from horse chestnuts, and of its trans isomer. (1971) (49)
Electrophysiological and biochemical studies on enhancement of desensitization by phenothiazine neuroleptics. (1983) (49)
Chemical Cleavage of Proteins (1968) (49)
INTRAMOLECULAR MIGRATION OF TRITIUM AND DEUTERIUM DURING NONENZYMATIC AROMATIC HYDROXYLATION. (1967) (48)
The Configuration of 5-Hydroxypipecolic Acid from Dates (1957) (48)
Studies on the Stereochemistry of Ephedrine and ψ-Ephedrine* (1957) (47)
Dye-sensitized Photooxygenation of Tyrptophan : 3a-Hydroperoxypyrroloindole as a Labile Precursor of Formylkynurenine (1981) (47)
Chapter 39 – Chemistry and Pharmacology of Frog Venoms (1971) (47)
sym-Homospermidine, a naturally occurring polyamine. (1971) (47)
Infrared Diagnosis of the Hydrochlorides of Organic Bases. II.1 The Structure of Myosmine (1954) (47)
THE INTERACTION OF MERCURIC ACETATE WITH INDOLES, TRYPTOPHAN, AND PROTEINS. (1964) (46)
Rapid spectrophotometric assays for snake venom L-amino acid oxidase based on the oxidation of L-kynurenine or 3,4-dehydro-L-proline. (1960) (45)
Differentiation of the open and closed states of the ionic channels of nicotinic acetylcholine receptors by tricyclic antidepressants. (1981) (45)
Studies on Schiff Bases in Connection with the Mechanism of Transamination (1954) (45)
THE SELECTIVE PHOTOREDUCTION OF URIDINE IN POLYNUCLEOTIDES. (1965) (45)
OXIDATION STUDIES OF INDOLES AND THE TERTIARY STRUCTURE OF PROTEINS. (1964) (44)
Potencies and channel properties induced by semirigid agonists at frog nicotinic acetylcholine receptors. (1983) (44)
The structure of sempervirine. (1949) (44)
Photo- and stereochemistry of 5,6-methylenepyrimidine nucleosides, bicylic isomers of thymidine, and 5-methyluridine. (1971) (44)
Reductive Cleavages of a Stable Ozonide1 (1952) (43)
Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor. (1977) (43)
2,4,5-TRIHYDROXYPHENETHYLAMINE, A NEW METABOLITE OF 3,4-DIHYDROXYPHENETHYLAMINE (1959) (41)
The reaction of derivatives of tryptophan, tryptamine, and other indoles with 2-hydroxy-5-nitrobenzyl bromide (Koshland's reagent). (1968) (40)
Gramicidin A. I. Determination of Composition and Amino Acid Configuration by Enzymatic and Gas Chromatographic Methods (1963) (40)
[59] Tryptophan involvement in the function of enzymes and protein hormones as determined by selective oxidation with N-bromosuccinimide (1967) (40)
The photoreduction of kynurenic acid to kynurenine yellow and the occurrence of 3-hydroxy-L-kynurenine in butterflies. (1967) (38)
The action of N-bromosuccinimide on trypsinogen and its derivatives. (1960) (38)
Differential Oxidation of Protein-Bound Tryptophan and Tyrosine by N-Bromosuccinimide in Urea Solution (1964) (37)
DEHYDROBUFOTENINE, A NOVEL TYPE OF TRICYCLIC SEROTONIN METABOLITE FROM Bufo Marinus (1961) (36)
Chemical and Enzymatic Routes to Methoxydopamines (1961) (36)
Monoamine oxidase inhibitors and procedures for their evaluation in vivo and in vitro. (1960) (36)
Oxindole Analogs of (5-Hydroxy)-tryptamine and -tryptophan, as Inhibitors of the Biosynthesis and Breakdown of Serotonin1 (1958) (35)
Hydroxylation-induced migrations of tritium in several substrates of liver aryl hydroxylases. (1967) (35)
Catecholamines and methyltransferases in the South American toad (Bufo marinus). (1962) (34)
Deuterium migration during the acid-catalyzed dehydration of 6-deuterio-5,6-dihydroxy-3-chloro-1,3-cyclohexadi-ene, a nonenzymic model for the NIH shift (1967) (34)
Studies on Carboline Anhydronium Bases (1953) (34)
Inhibitors of norepinephrine metabolism in vivo. (1959) (34)
PROGRESS IN NON-ENZYMATIC SELECTIVE MODIFICATION AND CLEAVAGE OF PROTEINS. (1964) (34)
Photoreduction of uridine and reduction of dihydrouridine with sodium borohydride. (1968) (34)
Twofold Wagner-Meerwein Rearrangements. II (1951) (34)
The stereochemistry of the catalytic and light-induced reduction of thymidine to dihydrothymidine and ureido alcohols. (1968) (33)
Interferon induction by synthetic polynucleotides: importance of purine N-7 and strandwise rearrangement. (1974) (33)
Preparation, Resolution and Optical Stability of 3,4-Dehydroproline and 3,4-Dehydroprolinamide (1962) (33)
The pharmacology of batrachotoxin. VII. Structure-activity relationships and the effects of pH. (1975) (32)
THE USE OF NEIGHBORING GROUP EFFECTS FOR THE SELECTIVE CLEAVAGE OF PEPTIDE BONDS. I. ON THE MECHANISM OF OXIDATION OF β- SUBSTITUTED INDOLES WITH N-BROMOSUCCIN-IMIDE1 (1958) (32)
The Stereochemistry of 3-Methylproline (1966) (31)
Chemistry of Catecholamines: Revised Structures for the Iodoaminochromes (1963) (31)
Cyclization of tryptophan and tryptamine derivatives to pyrrolo[2,3-b]indoles. (1968) (30)
SYNTHESIS AND BIOCHEMISTRY OF 5- AND 7- HYDROXYTRYPTOPHAN AND DERIVATIVES1 (1953) (30)
The Role of Cations in Non-enzymatic and Enzymatic O-Methylations of Catechol Derivatives (1962) (29)
Photolysis of arene oxides at low temperatures. Oxygen walks and keto tautomers of phenols (1974) (29)
Formyl, a Novel NH2-Terminal Blocking Group in a Naturally Occurring Peptide. The Identity of seco-Gramicidin with Desformylgramicidin (1964) (29)
The venom of the Colombian arrow poison frogPhyllobates bicolor (1963) (28)
Intramolecular migration of deuterium and tritium during enzymic hydroxylation of p-deuteroacetanilide and p-tritioacetanilide. (1967) (28)
ON THE MECHANISM OF OXIDATION OF INDOLE COMPOUNDS1,2 (1950) (27)
Remembering Heinrich Wieland (1877–1957) portrait of an organic chemist and founder of modern biochemistry (1992) (27)
The Cleavage of Tyrosyl-Peptide Bonds by Electrolytic Oxidation (1963) (27)
A potent interferon inducer derived from poly (7-deazainosinic acid). (1974) (27)
Synthesis and characterization of potential interferon inducers. Poly(2'-azido-2'-deoxyuridylic acid). (1973) (26)
Mechanisms of photochemical reactions in solution. LXV. Quenching of excited singlet states of electron-rich aromatic compounds by methyl chloroacetate (1970) (26)
On the Mechanism of Oxidation. IX. Oxidation and Autoxidation of Hydrazones1 (1953) (25)
Gramicidin A. II. Preparation and Properties of “seco-Gramicidin A” (1964) (25)
Metabolism of Lysergic Acid Diethylamide (1956) (25)
On the inability of tryptamine to serve as a precursor of serotonin. (1959) (25)
Sodium Borohydride Reduction of Quaternary Schiff Bases and Alkaloids (1953) (25)
The Reaction of Cyanogen Bromide with Mono- and Diamino Acids (1964) (24)
The heterogeneity of the S peptide of bovine pancreatic ribonuclease A. (1967) (23)
Alkylation and Cleavage of Methionine Peptides (1962) (23)
The Stereochemistry of the 1-Phenyl-1,2-propanediols and of α-Isoephedrine (1957) (23)
One-Step Synthesis and Enzymatic Resolution of cis- and trans-3-Hydroxyproline (1963) (23)
Isolation and synthesis of 3-hydroxy-L-proline (1962) (23)
The Conversion of Tetrahydroharman Alkaloids into Derivatives of Linear Pyrroquinolones1 (1953) (22)
Recent Studies on the Centrally Active Endogenous Amines (1963) (22)
Selective photoreduction of nucleotides and nucleic acids. II. Mechanism of the two-step reduction of thymidine. (1966) (22)
Notes. A Simple Method for the Preparation of Oxindoleacetic and Propionic Acids from the Parent Indoles (1961) (22)
An Unusual Twofold Wagner-Meerwein Rearrangement (1951) (22)
[61] Reactivity toward N-bromosuccinimide as a criterion for buried and exposed tryptophan residues in proteins (1967) (22)
On the Mechanism of Oxidation of o-Quinone by Hydrogen Peroxide1,2 (1957) (21)
Conformation and synthesis of diketopiperazines. 3,4-Dehydroproline anhydride (1974) (21)
THE STEREOSPECIFIC SYNTHESIS OF THREO-GAMMA-HYDROXYHOMO-L-ARGININE FROM LATHYRUS SPECIES. (1965) (21)
Photochemistry of the phthalimide system. VI. Photocyclization of N-alicyclic phthalimides. Synthesis of multicyclic benzazepine systems (1974) (21)
SPECIFIC CLEAVAGE OF METHIONYL PEPTIDES (1961) (21)
Voltage- and time-dependent effects of phencyclidines on the endplate current arise from open and closed channel blockade. (1986) (21)
Unexpected conformational stability of poly(2'-azido-2'-deoxyuridylic acid). (1972) (21)
Reductive ring openings of glutarimides and barbiturates with sodium borohydride. (1968) (20)
Hydrogenolysis and stereochemistry of photodimers of thymine and thymidine. (1971) (20)
New Methods for Nonenzymatic Peptide Cleavage. Electrolytic, Differential, and Solvolytic Cleabage of the Antibiotic Cyclopeptide Rufomycin (1964) (20)
Preparation of cis- and trans-Decahydroisoquinolines and of Bz-Tetrahydroisoquinoline (1948) (20)
Conformation of uncomplexed [Phe4, Val6] antamanide crystallized from nonpolar solvents. (1976) (20)
Biological, biochemical, and physicochemical evidence for the existence of the polyadenylic-polyuridylic-polyinosinic acid triplex. (1975) (20)
REARRANGEMENTS AND REVISIONS IN THE TETRAHYDROCARBAZOLE SERIES (1950) (20)
The Conversion of L-Histidine into Hydroxy- and Allohydroxy-proline via erythro- and threo-γ-Hydroxy-L-ornithine1,2 (1956) (20)
THE STRUCTURE OF QUINAMINE1 (1950) (19)
Antiviral activity of poly(7-deazainosinic acid)-derived complexes in vitro and in vivo. (1976) (19)
Selective exchange of nuclear protons in hydroxyindoles. (1967) (19)
Probes for a Regulatory Site on the Nicotinic Acetylcholine Receptor‐Channel. Synthesis of (±)‐7‐Debutylperhydrohistrionicotoxin, (±)‐2‐Depentyl‐7‐debutylperhydrohistrionicotoxin, and their Analogues (1985) (19)
Studies on the Chemical and Enzymatic Oxidation of Lysergic Acid Diethylamide1 (1957) (19)
Inhibition of oncornavirus functions by 2'-azido polynucleotides. (1975) (19)
Occurrence of cis- and trans-3-hydroxy-L-proline in acid hydrolyzate of telomycin. (1962) (19)
Photochemistry of the amide system. V. Synthetic photochemistry with heterocyclic anilides. Stereochemistry of the intramolecular 1,5-hydrogen shifts in nonoxidative photocyclization of benzo[b]thiophene-2-carboxanilides (1975) (19)
Dependence of interferon induction on nucleic acid conformation. (1976) (19)
Tricyclic analogs of melatonin. (1969) (19)
From the "Ordeal Bean" (Physostigma venenosum) to the Ordeal of Alzheimer's Disease ----- Some of the Legacy of Percy Lavon Julian (1899 - 1975) (1998) (18)
Photocyclizations of tyrosines, tyramines, catecholamines, and normescaline. (1968) (18)
On the Stereochemistry of Yohimbine (1949) (18)
Structural features of double-stranded polyribonucleotides required for immunological specificity and interferon induction. (1975) (17)
Synthesis and Metabolism of 6-Hydroxycatecholamines* (1965) (17)
Synthesis, chemistry, and biological activity of 5-thiocyanatopyrimidine nucleosides as potential masked thiols. (1974) (17)
Isolation and characterization of γ-L-glutamyl-S-(trans-1-propenyl)-L-cysteine sulfoxide from sandal (Santalum album). Interesting occurrence of sulfoxide diastereoisomers in nature (1974) (17)
The Use of Various Aminomalonates in the Synthesis of α-Substituted Tryptophans (1953) (17)
New directions in the chemistry of natural products: The organic chemist as a pathfinder for biochemistry and medicine (1971) (16)
Gelsemine. II. The Chemistry and Rearrangements of Spiroöxindoles1 (1953) (16)
Conversion of Baikiain to trans-5- and trans-4-Hydroxypipecolic Acids by Hydroboration (1964) (16)
Photocyclizations of pharmacodynamic amines. V. Unusual rearrangements of the mescaline skeleton. (1970) (15)
Sythesis of cis- and trans-4-mercapto-L-proline derivatives. (1970) (15)
The structure of ketoyobyrine. (1948) (15)
Effect of pyrimidine and ribose modifications on the antiviral activity of synthetic polynucleotides. (1973) (15)
(+/-)-2-Depentylperhydrohistrionicotoxin: a new probe for a regulatory site on the nicotinic acetylcholine receptor-channel. (1982) (15)
Intramolecular Migrations during Hydroxylation of Aromatic Compounds: The NIH Shift (1968) (15)
MECHANISMS OF PHOTOREDUCTIONS AND HYDROGENOLYSIS OF PYRIMIDINE NUCLEOSIDES AND THEIR PHOTODIMERS (1968) (14)
The chemorelease of norepinephrine in mouse hearts. Structure-activity relationships. II. Drugs affecting the sympathetic and central nervous systems. (1966) (14)
Sulfur analogs of dopamine and norepinephrine. Inhibition of catechol-O-methyltransferase. (1972) (14)
Participation of Isolated Double Bonds in the Cleavage of Peptides with N-Bromosuccinimide (1962) (14)
Photocyclization of pharmacodynamic amines. IV. Novel heterocycles from n-chloroacetyl-3,4-dimethoxyphenethylamine. (1970) (14)
The depletion of cardiac norepinephrine by 3,5-dihydroxy-4-methoxyphenethylamine and related compounds. (1967) (14)
Chemical conversion of tyrosine to 6-hydroxyindoles. (1967) (14)
Acid- and Base-catalyzed Rearrangements of a Ring-Chain Tautomeric Ozonide1,2 (1952) (14)
Enzymatic hydration of 8,9-indan oxide, Homoallylic addition of water. (1970) (14)
Approaches to analogs of anhydrogliotoxin. (1973) (13)
Influence of methylproline isomers upon actinomycin biosynthesis. (1966) (13)
Interferon Induction: Tool for Establishing Interactions among Homopolyribonucleotides (1974) (13)
Synthesis of 5-hydroxypipecolic acid and separation of its diastereoisomers. (1956) (13)
Enzymatic synthesis of polynucleotides containing 5,6-methylene- and 5,6-dihydropyrimidines. (1972) (13)
Proton magnetic resonance spectra of 3,4-dehydroproline derivatives (1966) (13)
Synthese von (±)-Adalin (1980) (13)
Preparation and photochemistry of 5,6-cyclopropyluridines and of bicyclic isomers of thymines. (1969) (13)
The structure of solaphyllidine, a novel 4-ketosteroidal alkaloid. (1970) (13)
Chemistry of Dihydroxyfumaric Acid (1954) (13)
CONVERSION OF PROLINE-14C TO COLLAGEN TRANS-3-HYDROXYPROLINE-14C IN THE CHICK EMBRYO. (1964) (12)
Batrachotoxin, an extremely active cardio- and neurotoxin from the Colombian arrow poison frog Phyllobates aurotaenia. (1971) (12)
The nonenzymatic conversion of tyrosine into mono- and dihydroxyindoles. (1968) (12)
Photochemistry of steroids. (1972) (12)
Polynucleotide duplexes based on poly(7-deazaadenylic acid). (1975) (11)
Protection of tryptophan during cleavage of tyrosine peptide bonds by N-bromosuccinimide. (1967) (11)
Crystalline Ozonides from cis—trans-Ethylene Derivatives1 (1953) (11)
Forty Years of Tryptifun (1983) (11)
Chemical and Enzymatic Studies of the Labile Metabolite 4(5H)-Imidazoline-5-acetic Acid1 (1959) (11)
[60] Tryptophan involvement in binding sites of proteins and in enzyme-inhibitor complexes as determined by oxidation with N-bromosuccinimide (1967) (11)
An unusual reaction of skatole with tetranitromethane. (1969) (11)
Photocyclizations of pharmacodynamic amines. II. X-ray analysis of a noncentrosymmetric tetracyclic indole. (1968) (11)
A new, practical synthesis of L-2-hydroxytryptophan and its derivatives. (1974) (11)
Heinrich Wieland Centennial: His Lifework and His Legacy Today† (1977) (11)
The Betaines of 3-Hydroxyproline. Assignment of Configuration and Inhibition of Acetylcholinesterase (1964) (10)
Preparation and photochemistry of py rimidine nucleoside sulfonium ylides. (1971) (10)
THE COMBINATION OF ENZYMATIC RESOLUTION WITH ASYMMETRIC TRANSFORMATION OF THE OPTICALLY LABILE 3,4-DEHYDROPROLINE AMIDE (1960) (10)
Chemical evidence for the involvement of tryptophan in the interaction of trypsin with the inhibitor from beef pancreas. (1965) (10)
Rearrangements of Dehydroproline Derivatives (1962) (10)
Labilization of Ester Bonds in Aminocyclitol Derivatives. II. Polyacetates of Deoxystreptamine1 (1960) (10)
The depletion of norepinephrine-3H from heart by alpha-methyl-m-tyrosine. A novel and convenient method for assaying the inhibition of aromatic amino acid decarboxylase in vivo. (1966) (10)
The combined use of alpha-methyltyrosine and threo-dihydroxyphenylserine--selective reduction of dopamine levels in the central nervous system. (1968) (10)
Photosensitized hydration of cholesterol. (1969) (10)
Fragmentation d'alcool allylique et homo-allylique en serie steroide. Oxydo methylene-3β,5β a nor cholestane (1972) (10)
Studies on 4-Keto-L-Proline (1959) (9)
2,4,5-Trimethylpyrrole-3-carboxylic acid esters of various alkaloids. (1974) (9)
EXCIPLEXES AND CAGE COMPLEXES IN THE PHOTOLYSIS OF N‐CHLOROACETYLMESCALINE AND OTHER PHENETHYLAMINES (1972) (9)
Selective N-methylations of heterocycles with dimethyloxosulfonium methylide (1970) (9)
The chemorelease of norepinephrine from mouse hearts. IV. Structure-activity relationships. Reserpines and yohimbines. (1968) (9)
Failure of duplexes based on polylaurusin (poly(L), "Polyformycin B") to induce interferon. (1975) (9)
Release of kinin activity from human kininogens and fresh plasma by cyanogen bromide. (1966) (9)
Stereochemistry of the Conversion of Allylglycine to γ-Hydroxyornithine and 4-Hydroxyproline (1963) (9)
Alkali sensitikvity of 3-methylpyrimidine nucleosides. (1971) (9)
Selective photoreductions of nucleic acids and their building stones. 8. Photoreduction and dimerization of 1,3-dimethyluracil. (1969) (9)
Polynucleotide displacement reactions: detection by interferon induction. (1976) (8)
The Acetylcholinesterase Surface. VII. Interference with the Surface Binding as Reflected by Enzymatic Response to Turicine, Betonicine and Related Heterocycles1 (1957) (8)
The separation of optical isomers of β-methyllanthionine (1966) (8)
The selective oxidation of sulfur-containing amino acids by diethyl azodicarboxylate. (1967) (8)
Triple-helical polynucleotides. Mixed triplexes of the poly(uridylic acid)-poly(adenylic acid)-poly(uridylic acid) class. (1976) (8)
Notes- Quebrachamine. II (1960) (8)
An easy access to 5-mercaptopyrimidine nucleosides through one-step synthesis of 5-thiocyanato-uridine and -2′-deoxyuridine (1972) (8)
A convenient method for the preparation of S-peptide from bovine pancreatic ribonuclease. (1966) (8)
The Synthesis of erythro-γ-Hydroxy-L-lysine and Its Nonoccurrence in Collagen* (1965) (8)
Antiviral activity of 5-thiocyanatopyrimidine nucleosides. (1975) (8)
Photocyclizations of N-chloroacetyltyramine. I. Formation of novel dimeric cage compounds. (1974) (8)
The Preparation of 4-H3-Hydroxy- and 4-H3-Allohydroxy-L-proline (1962) (7)
The Synthesis and Properties of N,N-Dialkylaminovinylindoles (1962) (7)
The venoms of amphibians. (1966) (7)
Photocyclizations of pharmacodynamic amines. 3. Three-dimensional structure of 7-hydroxy-1,9,10-trimethoxy-4-azabicyclo [5.2.2] undeca-8,10-dien-3-one from mescaline. (1969) (7)
Antiviral and antimetabolic activities of poly (7-deazaadenylic acid) and poly (7-deazainosinic acid). (1975) (7)
The Synthesis of 2-Carboxydeoxyeserolines via β-Methyl-ψ-tryptophan1 (1955) (7)
Antagonism of carbamylcholine-induced depolarization by batrachotoxin and veratridine. (1978) (7)
Photoreductions of 3,17-beta-estradiol. (1967) (7)
The application of Hudson's lactone rule toγ- andδ-hydroxyamino acids and the question of the configuration ofδ-hydroxy-l-lysine from collagen (1956) (7)
Factors Influencing the Separation of 4-Hydroxyproline Diastereomers by Ion-Exchange Chromatography (1964) (7)
The synthesis and metabolism of 2,3-dihydro-L-tryptophan and 2,3-dihydro-5-hydroxy-DL-tryptophan. (1967) (7)
Spectrophotometric differences between aminoheterocyclic bases and their salts (1954) (7)
CONVERSION OF BENZOXAZINE HYDROPEROXIDES TO THE PARENT BENZOXAZINES (1) (1954) (7)
THE FORMATION AND REARRANGEMENT OF ISOCYANO PEPTIDES. (1965) (7)
The isolation and characterization of gamma-L-glutamyl-S-(trans-1-propenyl)-L-cysteine sulfoxide from sandal (Santalum album L). An interesting occurrence of sulfoxide diastereoisomers in nature. (1974) (6)
PAUL EHRLICH: HIS IDEAS AND HIS LEGACY (1982) (6)
Sodium borohydride reduction of steroidal ketones with and without irradiation. (1968) (6)
Stereospecific acid-catalyzed rearrangements of 5,12-dimethylpentacyclo[6.4.0.02,5.03,12.04,9]dodecane-6,11-diones with their strain release to bisnordiamantane and diprotoadamantane ring systems (1979) (6)
5-Hydroxy-5-hydroperoxybarbituric Acid (“Alloxan Hydroperoxide”) and Other Alloxan Adducts1 (1954) (6)
The selective photolysis of dihydrothymidine. (1968) (6)
A novel chiral microenvironmental probe at the active site of trypsin. Extrinsic cotton effects of acyl-trypsin possessing an enantiomeric pair of chromophores. (1980) (6)
Chapter 5 Amphibian Alkaloids (1983) (6)
Oxidation of Kynuramine Derivatives by Monoamine Oxidase and the Enzymatic Conversion of Dihydronorkynuramine to Indigo (1961) (6)
Notes. Cleavage of Ethyl 2,2-Diphenyl-4-pentenoyl-glycinate by Oxidants and Acids. (1961) (6)
Novel pyrimidine nucleoside oxosulfonium ylides and their photolysis to 2,2'-methylenecyclonucleosides. (1969) (6)
Anti-complement activity of polynucleotides. (1975) (6)
Über Den Mechanismus Der Brenzcatechin-Oxydase (Pyrocatechase)-Reaktion (1957) (5)
A convenient spectrophotometric procedure for the determination of amino-terminal tyrosine residues. (1968) (5)
Hydrogenolysis of thymien dimer to cyclobutanes by sodium borohydride. (1967) (5)
Labile lipophilic derivatives of norepinephrine capable of crossing the blood-brain barrier (1969) (5)
Anodic decarboxylation of glycidic acids. (1971) (5)
Photo-dearomatization. 1,2-Photoaddition of alcohol to N,3-dimethylphthalimide without photoenolization. (1982) (5)
The interaction of polyxanthylic acid with polyadenylic acid. (1977) (4)
Stereospecific acid-catalyzed rearrangement of 1,6-dimethylpentacyclo[6.4.0.02,7.03,10.06,9]dodecane-5,12-dione to a bisnordiadamantane (1975) (4)
Labilization of Ester Bonds in Aminocyclitol Derivatives. I. Derivatives of myo- and scyllo-Inositols and of Streptamine1 (1958) (4)
A study of the novel synthetic analog (+/-)-depentylperhydrohistrionicotoxin on the nicotinic receptor-ion channel complex. (1984) (4)
Further aspects of stereospecificity in interaction of polyfunctional amine derivatives with bio-logical receptors. (1962) (4)
The Acetylcholinesterase Surface. IX. Dependence of Competitive Inhibition by Diaminocyclohexane Derivatives on Substrate Level1a (1958) (4)
PHOTOCHEMISTRY OF THE AMIDE SYSTEM. V. SYNTHETIC PHOTOCHEMISTRY WITH HETEROCYCLIC ANILIDES. STEREOCHEMISTRY OF THE INTRAMOLECULAR 1,5-HYDROGEN SHIFTS IN NONOXIDATIVE PHOTOCYCLIZATION OF BENZO(B)THIOPHENE-2-CARBOXANILIDES (1976) (4)
Photolysis of N-chloroacetyl-O-methyl-L-tyrosine to an azaazulene. (1967) (4)
Reduction of tissue norepinephrine and blood pressure by 3,5-dihydroxy-4-methoxy-phenylalanine. (1968) (4)
Probing Ion Channels with Natural and Synthetic Heterocycles (1982) (4)
Chemical contributions to the mechanism of the biological oxidation of tryptophan (1952) (4)
Correlation of cis- and trans-3-methylproline with (allo) isoleucine. (1965) (4)
Some novel aspects of the chemistry of hydroxyindolenines (1950) (3)
Some toxicologic properties of a new sries of aryl ethers derived from trans-2-aminocyclohexanol. (1959) (3)
The role of biochemistry in drug design. (1967) (3)
Natural Toxins as Tools in Neurophysiology (1974) (3)
Poisonous animals and their venoms (1965) (3)
Synthese von rac.-Pumiliotoxin C (1975) (3)
Interaction of analogs of histrionicotoxin with the acetylcholine receptor ionic channel complex and membrane excitability. (1984) (3)
Irradiation studies and novel sodium borohydride reduction of 1,4-cholestadien-3-one. (1969) (3)
New demonstrations of the medium-size ring effect (1950) (3)
Retro-, intro- and perspectives of trypto-fun. (1991) (3)
The chemorelease of norepinephrine from mouse hearts. 3. 3,5-Dihydroxy-4-methoxyphenethylamines and related compounds. (1968) (3)
ON THE CONFORMATION AND SYNTHESIS OF DIKETOPIPERAZINES, 3,4-DEHYDROPROLINE ANHYDRIDE (1974) (2)
Substrates and inhibitors of dopamine-beta-oxidase. (1962) (2)
Photochemistry of conjugated nitrogen – carbonyl systems, 6. Photodimerization of 2,4‐dioxotetrahydropyridines (1988) (2)
ALLENIC AND ACETYLENIC SPIROPIPERIDINE ALKALOIDS FROM THE NEOTROPICAL FROG. DENDROBATES HISTRIONICUS (1975) (2)
Fluorescent derivatives of strophanthidin. Interaction with sodium- and potassium-activated adenosine triphosphatase. (1972) (2)
Significance and rearrangements of quinol models of tyrosine metabolites (1952) (2)
Acetylcholinesterase inhibitory activities of muscarine and muscarone derivatives (1959) (2)
CLEAVAGE OF OLEFINIC PEPTIDES UNDER THE CONDITIONS OF OXYMERCURATION. (1964) (2)
Transient Cyclohexadienones by Novel Reversal Reactions from Cage Photodimers Derived from N‐Chloroacetyltyramines (1973) (2)
The synthesis and reactions of a tetrachlorodioxopiperazine. (1972) (2)
PHOTOCYCLIZATIONS OF N-CHLOROACETYLTRYRAMINE PART 1, FORMATION OF NOVEL DIMERIC CAGE COMPOUNDS (1974) (2)
Peptides in health and disease: Retrospection and outlook (1992) (2)
Forty Years of Trypto-Fun (1984) (2)
ACTIONS OF NEUROTOXINS ON THE ACETYLCHOLINE RECEPTOR–IONIC CONDUCTANCE MODULATOR UNIT AND ON SODIUM CHANNELS (1976) (1)
Intramolecular migrations of aryl substituents during enzymatic hydroxylation. (1968) (1)
[Frog venoms. Isolation and structure of pumiliotoxin]. (1969) (1)
Chapter 3 - Stepping Stones – Building Bridges (1995) (1)
Incorporation of tritium into irradiated nucleotides. (1968) (1)
Theodor Hermann Felix Wieland (5 June 1913-24 November 1995). (1998) (1)
From the “Ordeal Bean” (Physostigma venenosum) to the Ordeal of Alzheimer′s Disease — Some of the Legacy of Percy Lavon Julian. (1999) (1)
The application of Hudson's lactone rule to gamma- and delta-hydroxyamino acids and the question of the configuration of delta-hydroxy-L-lysine from collagen. (1956) (1)
Chemical cleavage of proteins. Selective fragmentations and modifications reveal structure. (1968) (1)
ORGANIC CHEMISTRY IN A BIOMEDICAL RESEARCH ORGANIZATION (1984) (1)
THE NIH SHIFT AND ITS IMPLICATIONS FOR THE MECHANISM OF BIOLOGICAL OXIDATIONS (1974) (1)
Labilization of ester bonds in aminodeoxyinositol derivatives as mediated by molecular conformation (1958) (1)
Identification and characterization of natural and synthetic dihydroxyprolines. (1969) (1)
PHOTOCHEMISTRY OF THE PHTHALIMIDE SYSTEM. 29. PHOTO-DEAROMATIZATION. 1,2-PHOTOADDITION OF ALCOHOL TO N,3-DIMETHYLPHTHALIMIDE WITHOUT PHOTOENOLIZATION (1983) (1)
A Chemist in a Biomedical Institute (1998) (1)
[32] Miscellaneous nonenzymatic cleavages of the peptide bond (1967) (1)
Biochemistry Extended: Blondes in Venetian Paintings, the Nine-Banded Armadillo, and Other Essays in Biochemistry. (1996) (0)
Synthesis of (?)-adaline (1980) (0)
From Natual Product to Curatives: Refrections on Arnold Brossi's Career and Contributions (1994) (0)
Seeking the Meaning of Biochemistry (1992) (0)
PHOTOLYSIS OF ARENE OXIDES AT LOW TEMPERATURES, OXYGEN WALKS AND KETO TAUTOMERS OF PHENOLS (1974) (0)
Letter from Robert S. Adelstein, Christian B. Anfinsen, Julius Axelrod, Jack S. Cohen, Philip Leder, Maxine Singer, Bernhard Witkop, Earl R. Stadtman to Richard M. Nixon (1973) (0)
The reaction oftrans-decahydroquinoline with molecular oxygen (1954) (0)
The Chemist’s Magic Bullets: Selectivity as a Guiding Principle in Biomedical Research (1981) (0)
A NEW, PRACTICAL SYNTHESIS OF L-2-HYDROXYTRYPTOPHAN AND ITS DERIVATIVES (1974) (0)
Proceedings: Inhibition of mouse leukemia virus RNA-dependent DNA polymerase by 2'-OH-substituted polynucleotides. (1974) (0)
D-5-4 Studies on Gramicidin A(Amino acids and peptides) (1964) (0)
Recent Contributions to the Chemistry and Biochemistry of some Amino Acids (1962) (0)
Additions and Corrections-Addition Reactions and Wagner-Meerwein Rearrangements in the Indoxyl Series (1951) (0)
GEPHYROTOXINS, HISTRIONICOTOXINS AND PUMILIOTOXINS FROM THE NEOTROPICAL FROG DENDROBATES HISTRIONICUS (1977) (0)
[Not Available]. (1998) (0)
Transcript of oral history of Julius Axelrod by Marshall Nirenberg and Bernhard Witkop (2003) (0)
SYNTHESIS, CHEMISTRY, AND BIOLOGICAL ACTIVITY OF 5-THIOCYANATOPYRIMIDINE NUCLEOSIDES AS POTENTIAL MASKED THIOLS (1974) (0)
SYNTHESIS AND ANTIVIRAL ACTIVITIES OF NEW 5-SUBSTITUTED PYRIMIDINE NUCLEOSIDE ANALOGS (1980) (0)
A Study of the Novel Synthetic Analog (Plus or Minus)- Depentylperhydrohistrionicotoxin on the Nicotinic Receptor-Ion Channel Complex, (1984) (0)
PHOTOCHEMISTRY OF THE PHTHALIMIDE SYSTEM PART 6, PHOTOCYCLIZATION OF N-ALICYCLIC PHTHALIMIDES, PHOTOINDUCED REACTIONS PART 15, SYNTHESIS OF MULTICYCLIC BENZAZEPINE SYSTEMS (1974) (0)
D-5-5 Non-enzymatic Peptide Cleavages of the Antibiotic Cyclopeptide Rufomycin(Amino acids and peptides) (1964) (0)
Cleavage of Proteins without Enzymes (1962) (0)
SIGNIFICANCE OF THE NIH SHIFT WITH RESPECT TO LIVER MICROSOME HYDROXYLATIONS (1969) (0)
2,4,5-TRIMETHYLPYRROLE-3-CARBOXYLIC ACID ESTERS OF VARIOUS ALKALOIDS (1974) (0)
Correction. Acid-and Base-catalyzed Rearrangements of a Ring-Chain Tautomeric Ozonide (1952) (0)
The reaction of transdecahydroquinoline with molecular oxygen. (1954) (0)
[Design of polynucleotides that act as inducers of interferon (author's transl)]. (1976) (0)
Isolation of rhazidine and akuammidine from . The structure of rhazidine. (1967) (0)
TOTAL SYNTHESIS AND ELECTROPHYSIOLOGICAL PROPERTIES OF NATURAL (-)-PERHYDROHISTRIONICOTOXIN, ITS UNNATURAL (+)-ANTIPODE AND THEIR 2-DEPENTYL ANALOGS (1982) (0)
499 – ACTIONS OF NEUROTOXINS ON THE ACEIYLCHOLINE RECEPTOR-IONIC CONDUCTANCE MODULATOR UNIT AND ON SODIUM CHANNELS (1977) (0)
Photoinduced Reaction. Part 106. Photochemistry of Conjugated Nitrogen-Carbonyl Systems. Part 6. Photodimerization of 2,4-Dioxotetrahydropyridines. (1989) (0)
PROGRESS IN NON-ENZYMATIC SELECTIVE MODIFICATION AND CLEAVAGE OF PROTEINS (1966) (0)
PROBES FOR A REGULATORY SITE ON THE NICOTINIC ACETYLCHOLINE RECEPTOR-CHANNEL. SYNTHESIS OF (.+-.)-7-DEBUTYLPERHYDROHISTRIONICOTOXIN, (.+-.)-2-DEPENTYL-7-DEBUTYLPERHYDROHISTRIONICOTOXIN, AND THEIR ANALOGS (1985) (0)
Biochemistry Extended: Blondes in Venetian Paintings, the Nine-Banded Armadillo, and Other Essays in Biochemistry . Konrad Bloch. Yale University Press, New Haven, CT, 1995. xiv, 261 pp., illus. $30 or £17.95. (1996) (0)
(.+-.)-2-DEPENTYLPERHYDROHISTRIONICOTOXIN: A NEW PROBE FOR A REGULATORY SITE ON THE NICOTINIC ACETYLCHOLINE RECEPTOR-CHANNEL (1983) (0)
STEREOSPECIFIC ACID-CATALYZED REARRANGEMENT OF 1,6-DIMETHYLPENTACYCLO(6.4.0.0(2,7).0(3,10).0(6,9))DODECANE5,12-DIONE TO A BISNORDIADAMANTANE (1975) (0)
Additions and Corrections-Rearrangements and Revisions in the Tetrahydrocarbazole Series (1951) (0)
The separation of optical isomers of beta-methyllanthionine. (1966) (0)
Progress in the Chemistry of Organic Natural Products . vol. XII. L. Zechmeister, Ed. Springer, Vienna, 1955. x+550 pp. $19.80. (1956) (0)
SYNTHESIS OF PUMILIOTOXIN C (1976) (0)

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