Bert Vogelstein

Q: What Schools Are Affiliated With Bert Vogelstein

Bert Vogelstein is affiliated with the following schools: University of Texas Southwestern Medical Center, University of Pennsylvania, University of Maryland, College Park, Medical University of Vienna, University of Leeds, University of New South Wales, University of Chicago, Baylor College of Medicine, Columbia University, Duke University, Brown University, Washington University in St. Louis, Yale University, University of Edinburgh, Deakin University, Case Western Reserve University, Johns Hopkins University, University of Pittsburgh

Bert Vogelstein's AcademicInfluence.com Rankings

Bert Vogelstein

Biology

#207

World Rank

#378

Historical Rank

#121

USA Rank

Genetics

#22

World Rank

#40

Historical Rank

#16

USA Rank

biology Degrees

Bert Vogelstein

Philosophy

#693

World Rank

#1345

Historical Rank

#311

USA Rank

Logic

#63

World Rank

#186

Historical Rank

#30

USA Rank

philosophy Degrees

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Biology
Philosophy

Why Is Bert Vogelstein Influential?

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According to Wikipedia, Bert Vogelstein is director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a Howard Hughes Medical Institute investigator at The Johns Hopkins Medical School and Sidney Kimmel Comprehensive Cancer Center. A pioneer in the field of cancer genomics, his studies on colorectal cancers revealed that they result from the sequential accumulation of mutations in oncogenes and tumor suppressor genes. These studies now form the paradigm for modern cancer research and provided the basis for the notion of the somatic evolution of cancer.

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Bert Vogelstein's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. (1983) (22892)
A genetic model for colorectal tumorigenesis (1990) (11891)
WAF1, a potential mediator of p53 tumor suppression (1993) (8623)
p53 mutations in human cancers. (1991) (8282)
Surfing the p53 network (2000) (6492)
Cancer Genome Landscapes (2013) (6203)
Genetic alterations during colorectal-tumor development. (1988) (5548)
Lessons from Hereditary Colorectal Cancer (1996) (5073)
Identification of c-MYC as a target of the APC pathway. (1998) (4868)
An Integrated Genomic Analysis of Human Glioblastoma Multiforme (2008) (4366)
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade (2017) (4313)
Cancer genes and the pathways they control (2004) (4247)
Genetic instabilities in human cancers (1998) (4217)
Participation of p53 protein in the cellular response to DNA damage. (1991) (3972)
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses (2008) (3758)
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. (2015) (3718)
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies (2014) (3526)
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma (1997) (3456)
High Frequency of Mutations of the PIK3CA Gene in Human Cancers (2004) (3428)
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC (1997) (3376)
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia (1992) (3220)
IDH1 and IDH2 mutations in gliomas. (2009) (3013)
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. (1998) (2974)
PD-1 blockade in tumors with mismatch repair deficiency. (2015) (2914)
Surfing the p 53 network (2000) (2905)
The Consensus Coding Sequences of Human Breast and Colorectal Cancers (2006) (2878)
Mutations in the p53 gene occur in diverse human tumour types (1989) (2806)
A simplified system for generating recombinant adenoviruses. (1998) (2702)
The Genomic Landscapes of Human Breast and Colorectal Cancers (2007) (2549)
A model for p53-induced apoptosis (1997) (2531)
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. (1995) (2466)
Hypomethylation distinguishes genes of some human cancers from their normal counterparts (1983) (2387)
Identification of FAP locus genes from chromosome 5q21. (1991) (2379)
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer (1993) (2347)
Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer (2010) (2299)
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. (1989) (2166)
Serial Analysis of Gene Expression (1995) (2145)
Amplification of a gene encoding a p53-associated protein in human sarcomas (1992) (2074)
Definition of a consensus binding site for p53 (1992) (2053)
APC mutations occur early during colorectal tumorigenesis (1992) (2025)
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. (1998) (2005)
Genetic instability in colorectal cancers (1997) (1997)
p53 function and dysfunction (1992) (1955)
The multistep nature of cancer. (1993) (1925)
Prevalence of ras gene mutations in human colorectal cancers (1987) (1888)
Suppression of human colorectal carcinoma cell growth by wild-type p53. (1990) (1861)
Genes expressed in human tumor endothelium. (2000) (1839)
Circulating mutant DNA to assess tumor dynamics (2008) (1754)
Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 (2011) (1652)
Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer (1994) (1620)
Mutations of mitotic checkpoint genes in human cancers (1998) (1562)
Detection and localization of surgically resectable cancers with a multi-analyte blood test (2018) (1556)
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers (2012) (1550)
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 (1993) (1530)
DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors (2011) (1474)
Digital PCR. (1999) (1441)
Variation in cancer risk among tissues can be explained by the number of stem cell divisions (2015) (1398)
Preparative and analytical purification of DNA from agarose. (1979) (1397)
Allelotype of colorectal carcinomas. (1989) (1362)
PUMA induces the rapid apoptosis of colorectal cancer cells. (2001) (1328)
Association of the APC tumor suppressor protein with catenins. (1993) (1299)
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status (2002) (1288)
p21 is necessary for the p53-mediated G1 arrest in human cancer cells. (1995) (1278)
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells (2002) (1259)
Erratum: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene (1992) (1255)
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. (1990) (1183)
14-3-3σ Is a p53-Regulated Inhibitor of G2/M Progression (1997) (1160)
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal (2013) (1148)
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. (1995) (1140)
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma (2010) (1123)
The Genetic Basis of Human Cancer (1997) (1106)
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. (1999) (1103)
Detection and quantification of mutations in the plasma of patients with colorectal tumors. (2005) (1076)
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. (2015) (1068)
Hypermutability and mismatch repair deficiency in RER+ tumor cells (1993) (1060)
Identification of p53 as a sequence-specific DNA-binding protein (1991) (1055)
PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs (1999) (1044)
The colorectal microRNAome. (2006) (999)
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response (1990) (994)
Detection and quantification of rare mutations with massively parallel sequencing (2011) (992)
Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer (1998) (944)
Role of BAX in the apoptotic response to anticancer agents. (2000) (924)
Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer (2016) (922)
Gene expression profiles in normal and cancer cells. (1997) (901)
Hypomethylation of DNA from benign and malignant human colon neoplasms. (1985) (896)
Altered Telomeres in Tumors with ATRX and DAXX Mutations (2011) (894)
Structural alterations of the epidermal growth factor receptor gene in human gliomas. (1992) (887)
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. (1985) (883)
14-3-3σ is required to prevent mitotic catastrophe after DNA damage (1999) (878)
Mutant PIK3CA promotes cell growth and invasion of human cancer cells. (2005) (867)
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. (1987) (862)
Gatekeepers and caretakers (1997) (853)
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells (2009) (848)
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability (1995) (845)
Somatic mutations of the mitochondrial genome in human colorectal tumours (1998) (841)
p53 functions as a cell cycle control protein in osteosarcomas (1990) (823)
Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. (1994) (823)
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21 (1996) (817)
A protocol for rapid generation of recombinant adenoviruses using the AdEasy system (2007) (803)
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations (2003) (798)
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. (1995) (794)
Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene (2009) (788)
Genetic instability and darwinian selection in tumours. (1999) (785)
Analysis of human transcriptomes (1999) (783)
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. (1991) (772)
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. (1984) (771)
Comparative lesion sequencing provides insights into tumor evolution (2008) (771)
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention (2017) (767)
Clonal expansion of p53 mutant cells is associated with brain tumour progression (1992) (742)
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. (1992) (741)
Accumulation of driver and passenger mutations during tumor progression (2009) (734)
Allelic loss of chromosome 18q and prognosis in colorectal cancer. (1994) (729)
The Genetic Landscape of the Childhood Cancer Medulloblastoma (2011) (711)
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development (2011) (711)
Identification of an amplified, highly expressed gene in a human glioma. (1987) (703)
Cancer risk associated with germline DNA mismatch repair gene mutations. (1997) (702)
Characterization of the Yeast Transcriptome (1997) (699)
Human Smad3 and Smad4 are sequence-specific transcription activators. (1998) (687)
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC (1997) (686)
A Phosphatase Associated with Metastasis of Colorectal Cancer (2001) (656)
Clonal analysis of human colorectal tumors. (1987) (647)
Using the transcriptome to annotate the genome (2002) (645)
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers (1996) (632)
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis (2001) (629)
Scrambled exons (1991) (622)
Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. (1998) (619)
A fixed site of DNA replication in eucaryotic cells (1980) (612)
Cancer-susceptibility genes. Gatekeepers and caretakers. (1997) (609)
PUMA mediates the apoptotic response to p53 in colorectal cancer cells (2003) (598)
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. (2012) (592)
Allelic Variation in Human Gene Expression (2002) (591)
14-3-3sigma is a p53-regulated inhibitor of G2/M progression. (1997) (579)
Colorectal cancer: Mutations in a signalling pathway (2005) (578)
Supercoiled loops and eucaryotic DNA replication (1980) (577)
Inactivation of hCDC4 can cause chromosomal instability (2004) (568)
Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing (2012) (568)
p53 Mutation and MDM2 amplification in human soft tissue sarcomas. (1993) (563)
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas (2013) (555)
Molecular determinants of dysplasia in colorectal lesions. (1994) (554)
Landscaping the Cancer Terrain (1998) (553)
An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms (1994) (551)
Evolutionary dynamics of cancer in response to targeted combination therapy (2013) (547)
Apoptosis and APC in colorectal tumorigenesis. (1996) (544)
The significance of unstable chromosomes in colorectal cancer (2003) (538)
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways (2011) (535)
Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers (2004) (533)
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas (2012) (532)
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. (1992) (529)
The Antisense Transcriptomes of Human Cells (2008) (526)
Clonal origin of bladder cancer. (1992) (521)
The role of chromosomal instability in tumor initiation (2002) (520)
Contribution of bone marrow–derived endothelial cells to human tumor vasculature (2005) (519)
Combinatorial chemoprevention of intestinal neoplasia (2000) (518)
APC binds to the novel protein EB1. (1995) (516)
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome (1990) (509)
Oncogenic forms of p53 inhibit p53-regulated gene expression (1992) (505)
Genetic determinants of p53-induced apoptosis and growth arrest. (1996) (502)
Heteroplasmic mitochondrial DNA mutations in normal and tumor cells (2010) (501)
Hypomethylation of ras oncogenes in primary human cancers. (1983) (497)
Microbiota organization is a distinct feature of proximal colorectal cancers (2014) (496)
Identification of CDK4 as a target of c-MYC. (2000) (495)
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway (2012) (492)
Combination bacteriolytic therapy for the treatment of experimental tumors (2001) (490)
Identification and classification of p53-regulated genes. (1999) (484)
CpG methylation is maintained in human cancer cells lacking DNMT1 (2000) (484)
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. (1998) (479)
Oncogenic forms of p53 inhibit p53-regulated gene expression. (1992) (477)
The APC gene product in normal and tumor cells. (1993) (473)
Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia (2004) (472)
Deletion of p16 and p15 genes in brain tumors. (1994) (464)
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells (2014) (461)
Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer. (2015) (461)
Clonal analysis using recombinant DNA probes from the X-chromosome. (1987) (457)
A public database for gene expression in human cancers. (1999) (447)
Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. (1999) (446)
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations (2007) (442)
Absence of WAF1 mutations in a variety of human malignancies. (1994) (439)
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. (2003) (436)
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. (2001) (431)
BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions (2006) (429)
ATM mutations in patients with hereditary pancreatic cancer. (2012) (427)
Cell surface tumor endothelial markers are conserved in mice and humans. (2001) (426)
Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. (2009) (425)
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome (2011) (425)
Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours (1984) (424)
Sequence-specific transcriptional activation is essential for growth suppression by p53. (1994) (423)
DNA methylation and genetic instability in colorectal cancer cells. (1997) (423)
Cell-cycle arrest versus cell death in cancer therapy (1997) (420)
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity (2015) (417)
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. (1990) (412)
Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing (2010) (410)
Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. (1985) (410)
Genetic Progression and the Waiting Time to Cancer (2007) (408)
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma (2011) (405)
Corrections and Clarifications: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene (1992) (403)
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers (2008) (403)
The GLI gene is a member of the Kruppel family of zinc finger proteins (1988) (401)
Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma (2011) (400)
Epitope landscape in breast and colorectal cancer. (2008) (396)
Molecular diagnosis of familial adenomatous polyposis. (1993) (396)
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. (1990) (395)
Top-down morphogenesis of colorectal tumors (2001) (393)
Genetic alterations in the adenoma–carcinoma sequence (1992) (392)
Securin Is Required for Chromosomal Stability in Human Cells (2001) (389)
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers (2017) (387)
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma (2012) (379)
Cancer‐Associated Mutations in Endometriosis without Cancer (2017) (375)
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation (2013) (374)
Genetic instability occurs in the majority of young patients with colorectal cancer (1995) (372)
Loss of genes on the short arm of chromosome 11 in bladder cancer (1985) (368)
Tumour suppression: Disruption of HAUSP gene stabilizes p53 (2004) (364)
APC mutations in colorectal tumors with mismatch repair deficiency. (1996) (364)
Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer (2014) (361)
Wild-type but not mutant APC associates with the microtubule cytoskeleton. (1994) (360)
Molecular determinants of immunogenicity: the immunon model of immune response. (1976) (350)
A deadly inheritance (1990) (347)
Detecting colorectal cancer in stool with the use of multiple genetic targets. (2001) (347)
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication (1991) (346)
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. (1999) (345)
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. (2012) (344)
Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas (2015) (343)
Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. (1990) (342)
Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells (2001) (340)
A combination of molecular markers and clinical features improve the classification of pancreatic cysts. (2015) (339)
Detection of APC mutations in fecal DNA from patients with colorectal tumors. (2002) (337)
Founding mutations and Alu-mediated recombination in hereditary colon cancer (1995) (334)
Allelic Loss in Colorectal Carcinoma (1989) (331)
Mutational analysis of the tyrosine kinome in colorectal cancers. (2003) (330)
SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer (2009) (329)
Frequency of Smad gene mutations in human cancers. (1997) (326)
Only three driver gene mutations are required for the development of lung and colorectal cancers (2014) (325)
Mismatch repair deficiency in phenotypically normal human cells (1995) (322)
The GLI-Kruppel family of human genes (1988) (319)
Sensitive digital quantification of DNA methylation in clinical samples (2009) (319)
Somatic mutations of EGFR in colorectal cancers and glioblastomas. (2004) (315)
Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia. (1986) (305)
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53 (2009) (304)
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers (2008) (300)
Inactivation of both APC alleles in human and mouse tumors. (1994) (299)
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway. (1994) (295)
The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells (1982) (294)
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. (1999) (290)
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord (2015) (290)
Small changes in expression affect predisposition to tumorigenesis (2002) (288)
Evaluating the evaluation of cancer driver genes (2016) (285)
Next-generation stool DNA test accurately detects colorectal cancer and large adenomas. (2012) (283)
Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer. (2019) (282)
Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. (1988) (281)
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer (2017) (281)
Cooperative effects of genes controlling the G(2)/M checkpoint. (2000) (280)
Somatic Mutations in the Chromatin Remodeling Gene ARID1A Occur in Several Tumor Types (2011) (278)
Conversion of diploidy to haploidy (2000) (274)
Inherited p53 gene mutations in breast cancer. (1992) (271)
Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses (2014) (270)
Gene amplification of c-myc and N-myc in small cell carcinoma of the lung. (1986) (269)
Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers (2013) (269)
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. (2016) (261)
The Path to Cancer --Three Strikes and You're Out. (2015) (261)
Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers (2004) (260)
Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer (1992) (259)
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention (2020) (257)
A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane (2009) (255)
BEAMing up for detection and quantification of rare sequence variants (2006) (251)
Bacteriolytic therapy can generate a potent immune response against experimental tumors. (2004) (250)
Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells (2001) (250)
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. (1995) (250)
MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. (2003) (249)
Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. (1991) (238)
Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]. (1989) (234)
Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene. (1991) (233)
Mechanisms underlying losses of heterozygosity in human colorectal cancers (2001) (231)
The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. (2007) (229)
The DCC gene: structural analysis and mutations in colorectal carcinomas. (1994) (225)
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. (2007) (224)
Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing (2013) (224)
Characterization of MAD2B and other mitotic spindle checkpoint genes. (1999) (224)
Association between wild type and mutant APC gene products. (1993) (219)
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors (2014) (218)
Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients. (2008) (217)
Characterization of human FAST-1, a TGFβ and activin signal transducer (1998) (216)
Amplification of cyclin genes in colorectal carcinomas. (1993) (215)
Mad-related genes in the human (1996) (214)
The Predictive Capacity of Personal Genome Sequencing (2012) (213)
Analysing uncharted transcriptomes with SAGE. (2000) (212)
TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine. (2013) (212)
Life (and death) in a malignant tumour (1996) (210)
Gene Amplification in Malignant Human Gliomas: Clinical and Histopathologic Aspects (1988) (209)
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome. (1998) (209)
PRL-3 expression in metastatic cancers. (2003) (209)
X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. (2004) (208)
Three classes of genes mutated in colorectal cancers with chromosomal instability. (2004) (207)
Paradoxical inhibition of solid tumor cell growth by bcl2. (1994) (207)
Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. (1998) (207)
Infrequent p53 gene mutations in medulloblastomas. (1991) (205)
Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. (2013) (204)
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. (1990) (202)
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity (1990) (201)
The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? (2014) (201)
Targeted inactivation of p53 in human cells does not result in aneuploidy. (2002) (200)
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. (2004) (198)
Minimal functional driver gene heterogeneity among untreated metastases (2018) (198)
The DCC gene product in cellular differentiation and colorectal tumorigenesis. (1994) (197)
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T (2007) (192)
Low‐grade serous carcinomas of the ovary contain very few point mutations (2012) (191)
Nomenclature: Vertebrate Mediators of TGFβ Family Signals (1996) (189)
Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers (2003) (188)
Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction. (1991) (187)
p53 tagged sites from human genomic DNA. (1994) (186)
Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers. (2016) (186)
HAUSP is Required for p53 Destabilization (2004) (186)
Can chromosomal instability initiate tumorigenesis? (2005) (185)
Prevalence of somatic alterations in the colorectal cancer cell genome (2002) (185)
Sulindac suppresses tumorigenesis in the Min mouse. (1996) (185)
Carcinogen-specific induction of genetic instability (2001) (184)
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. (2004) (183)
Carcinogens leave fingerprints (1992) (181)
Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas. (1992) (175)
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. (1998) (173)
Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. (1986) (173)
Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome (2018) (173)
Secreted and cell surface genes expressed in benign and malignant colorectal tumors. (2001) (172)
The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer Cells* (2003) (171)
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer (2016) (166)
Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. (1996) (166)
Counting alleles to predict recurrence of early-stage colorectal cancers (2002) (165)
GermlineSMAD4 orBMPRIA mutations and phenotype of juvenile polyposis (2002) (164)
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers (2015) (164)
Whole genome PCR: application to the identification of sequences bound by gene regulatory proteins. (1989) (162)
Carrier detection in X-linked agammaglobulinemia by analysis of X-chromosome inactivation. (1987) (160)
Cytogenetics and Molecular Genetics of Malignant Gliomas and Medulloblastoma (1990) (160)
Use of isogenic human cancer cells for high-throughput screening and drug discovery (2001) (160)
Mutation affecting the 12th amino acid of the c-Ha-ras oncogene product occurs infrequently in human cancer. (1983) (159)
Participation of p 53 Protein in the Cellular Response to DNA Damage 1 (2006) (157)
Detection of proximal colorectal cancers through analysis of faecal DNA (2002) (156)
Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas (2013) (156)
Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. (2007) (155)
TEM8 Interacts with the Cleaved C5 Domain of Collagen α3(VI) (2004) (154)
Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers (2018) (154)
Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing (2016) (154)
Mutant p53 proteins bind DNA abnormally in vitro. (1991) (153)
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria (2003) (150)
A multidimensional analysis of genes mutated in breast and colorectal cancers. (2007) (148)
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. (2006) (144)
A Bacterial Protein Enhances the Release and Efficacy of Liposomal Cancer Drugs (2006) (144)
Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. (1994) (144)
The role of companion diagnostics in the development and use of mutation-targeted cancer therapies (2006) (141)
Whole‐exome sequencing of pancreatic neoplasms with acinar differentiation (2014) (138)
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers (2021) (138)
The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. (2000) (136)
Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia. (1996) (136)
The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. (2001) (135)
Reconstructing metastatic seeding patterns of human cancers (2017) (135)
Targeting a neoantigen derived from a common TP53 mutation (2021) (134)
The association of transcriptionally active genes with the nuclear matrix of the chicken oviduct. (1983) (132)
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers (2009) (130)
Relationship between gene amplification and chromosomal deviations in malignant human gliomas. (1987) (130)
Polymerase δ variants in RER colorectal tumours (1995) (130)
Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1. (1992) (129)
Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma. (2016) (129)
In vivo cloning of PCR products in E. coli. (1993) (127)
Genetic knockouts and knockins in human somatic cells (2007) (127)
Genetic mutations associated with cigarette smoking in pancreatic cancer. (2009) (126)
Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation (2002) (125)
Analysis of masked mutations in familial adenomatous polyposis. (1999) (125)
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation (2010) (125)
Genomic organization of the human PMS2 gene family. (1995) (125)
Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. (2005) (125)
Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer. (2019) (123)
CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling (1999) (123)
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. (2003) (123)
The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT (2006) (123)
Evaluation of the FHIT gene in colorectal cancers. (1996) (123)
Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae (1992) (122)
The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma. (1992) (122)
The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A (1991) (121)
Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene. (1988) (120)
Screening for germ‐line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients (1992) (117)
Mutant proteins as cancer-specific biomarkers (2011) (117)
Applications of liquid biopsies for cancer (2019) (116)
APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis. (1997) (115)
A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype (1998) (114)
Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy (2018) (114)
Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer. (2022) (114)
TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI). (2004) (113)
Identifying markers for pancreatic cancer by gene expression analysis. (1998) (112)
Suppressor gene alterations in the colorectal adenoma‐carcinoma sequence (1992) (110)
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies. (1987) (109)
TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies. (1995) (108)
Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy. (2015) (108)
An analysis of genetic heterogeneity in untreated cancers (2019) (107)
Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution (2015) (105)
The Temporal Order of Genetic and Pathway Alterations in Tumorigenesis (2011) (105)
Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry. (2001) (104)
Mutant PIK 3 CA promotes cell growth and invasion of human cancer cells (2005) (102)
Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas. (1991) (102)
Remote loading of preencapsulated drugs into stealth liposomes (2014) (99)
Programmed death-1 blockade in mismatch repair deficient colorectal cancer. (2016) (98)
Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells (2001) (97)
PPAR d Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs (1999) (97)
Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen. (1990) (97)
No room at the p53 inn (1993) (97)
The relationship of the nuclear matrix to cellular structure and function. (1978) (95)
Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. (2001) (95)
Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours. (2007) (95)
Utility of CT Radiomics Features in Differentiation of Pancreatic Ductal Adenocarcinoma From Normal Pancreatic Tissue. (2019) (94)
A multimodality test to guide the management of patients with a pancreatic cyst (2019) (94)
The association of transcribed genes with the nuclear matrix of Drosophila cells during heat shock. (1985) (93)
Upper Extremity Physical Factors Affecting Tennis Serve Velocity (1994) (93)
Targeting Vascular and Avascular Compartments of Tumors with C. novyi-NT and Anti-microtubule Agents (2004) (92)
Characterization of human FAST-1, a TGF beta and activin signal transducer. (1998) (92)
Has the breast cancer gene been found? (1994) (92)
Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts. (1992) (91)
DEC1 is a downstream target of TGF-β with sequence-specific transcriptional repressor activities (2002) (89)
p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. (2000) (88)
Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas (2014) (88)
Protein factor(s) from mitotic CHO cells induce meiotic maturation in Xenopus laevis oocytes (1980) (88)
Cancer. A deadly inheritance. (1990) (88)
Colon cancer genetics (1992) (87)
Design and analysis issues in genome-wide somatic mutation studies of cancer. (2009) (87)
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers (2006) (87)
Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists. (2020) (86)
Localization of SV40 genes within supercoiled loop domains. (1980) (86)
Dynamics of Genetic Instability in Sporadic and Familial Colorectal Cancer (2002) (85)
Mutation Screening of the TNFRSF11A Gene Encoding Receptor Activator of NFkB (RANK) in Familial and Sporadic Paget's Disease of Bone and Osteosarcoma (2001) (85)
Structural comparisons of class I phosphoinositide 3-kinases (2008) (85)
Imaging of Musculoskeletal Bacterial Infections by [124I]FIAU-PET/CT (2007) (83)
Imaging of Musculoskeletal Bacterial Infections by [124I]FIAU-PET/CT (2007) (83)
Immunoglobulin gene rearrangements in remission bone marrow specimens from patients with acute lymphoblastic leukemia. (1986) (83)
Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors. (1991) (82)
Cancer therapy meets p53. (1994) (82)
Pharmacologic and toxicologic evaluation of C. novyi-NT spores. (2005) (80)
Carrier detection in the Wiskott Aldrich syndrome (1988) (80)
Patient-oriented gene set analysis for cancer mutation data (2010) (79)
Absence of secretory phospholipase A2 gene alterations in human colorectal cancer. (1995) (77)
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line. (2001) (76)
Very Long-term Survival Following Resection for Pancreatic Cancer Is Not Explained by Commonly Mutated Genes: Results of Whole-Exome Sequencing Analysis (2015) (75)
Precancerous neoplastic cells can move through the pancreatic ductal system (2018) (75)
Erratum: Genetic determinants of p53-induced apoptosis and growth arrest ((Genes and Development (1996) 10 (1945-1952)) (1996) (74)
Specific cellular stimulation in the primary immune response: experimental test of a quantized model. (1982) (74)
Please Don't Call It Cloning! (2002) (74)
Nomenclature: vertebrate mediators of TGFbeta family signals. (1996) (73)
Bispecific antibodies targeting mutant RAS neoantigens (2021) (73)
Achilles' heel of cancer? (2001) (73)
Gene Targeting in Human Cells Without Isogenic DNA (1999) (73)
Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer. (2019) (72)
SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells. (2004) (71)
PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers. (2016) (71)
Sequence analysis of nuclear matrix associated DNA from rat liver. (1980) (70)
Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke (2015) (70)
Lavage of the Uterine Cavity for Molecular Detection of Müllerian Duct Carcinomas: A Proof-of-Concept Study (2015) (70)
Counting alleles reveals a connection between chromosome 18q loss and vascular invasion (2001) (70)
Cancer risk: Role of environment—Response (2015) (70)
The pharmacokinetics of amikacin in children. (1977) (69)
IgH gene rearrangements as plasma biomarkers in Non-Hodgkin's Lymphoma patients (2011) (69)
Cell adhesion molecules as tumour suppressors. (1993) (68)
Amplification units containing human N-myc and c-myc genes. (1986) (68)
The relationship of quantitative nuclear morphology to molecular genetic alterations in the adenoma-carcinoma sequence of the large bowel. (1992) (68)
Asef , a Link Between the Tumor Suppressor APC and G-Protein Signaling (67)
Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia. (2011) (65)
Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma (2016) (65)
Exomic Sequencing of Four Rare Central Nervous System Tumor Types (2013) (65)
Activation of diverse signaling pathways by oncogenic PIK3CA mutations (2014) (62)
Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity (2012) (62)
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells (2014) (61)
Alterations in DNA methylation in human colon neoplasia. (1987) (60)
Short mononucleotide repeat sequence variability in mismatch repair-deficient cancers. (2001) (60)
Cancer prevention: Molecular and epidemiologic consensus (2018) (60)
Association of newly replicated DNA with the nuclear matrix of Physarum polycephalum. (1981) (60)
FAST-SeqS: A Simple and Efficient Method for the Detection of Aneuploidy by Massively Parallel Sequencing (2012) (59)
Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats (2015) (59)
Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation. (2002) (59)
Aristolochic Acid in the Etiology of Renal Cell Carcinoma (2016) (59)
Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse. (1993) (58)
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. (1999) (58)
Isolation and structural analysis of a 1.2-megabase N-myc amplicon from a human neuroblastoma (1992) (57)
Genotyping by mass spectrometric analysis of short DNA fragments (1998) (57)
Differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma with CT radiomics features. (2020) (57)
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations (2010) (56)
Identification of a Binding Partner for the Endothelial Cell Surface Proteins TEM7 and TEM7R (2004) (55)
Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study (2021) (55)
Supercoiled loops and the organization of replication and transcription in eukaryotes (1985) (55)
Lessons from Hereditary Review Colorectal Cancer (1996) (54)
Tumours of the colon and rectum: Carcinoma of the colon and rectum (2000) (54)
A diaCEST MRI approach for monitoring liposomal accumulation in tumors. (2014) (53)
Prognostic significance of postsurgery circulating tumor DNA in nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies (2020) (53)
Investigation of colon cancers for human papillomavirus genomic sequences by polymerase chain reaction (1992) (52)
Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence (2019) (51)
A nanoparticle formulation that selectively transfects metastatic tumors in mice (2013) (51)
Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience. (2019) (50)
Perceiving distance accurately by a directional process of integrating ground information (50)
A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. (1992) (50)
Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix. (1982) (50)
Hyper-recombination and genetic instability in BLM-deficient epithelial cells. (2003) (50)
Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. (1995) (50)
Exome sequencing identifies frequent inactivating mutations in BAP 1 , ARID 1 A and PBRM 1 in intrahepatic cholangiocarcinomas (2014) (49)
p 53-Dependent and independent expression of p 21 during cell growth , differentiation , and DNA damage (2007) (49)
RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study (1990) (49)
Evaluation of Clostridium novyi-NT spores in dogs with naturally occurring tumors. (2012) (48)
X-rays strike p53 again (1994) (48)
Structural basis of nSH2 regulation and lipid binding in PI3Kα (2014) (48)
Converting cancer genes into killer genes. (1996) (48)
Characterization of N-myc amplification units in human neuroblastoma cells (1988) (48)
Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localised pancreatic cancer. (2019) (47)
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket. (2008) (45)
Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis (2011) (45)
GNAS Sequencing Identifies IPMN-specific Mutations in a Subgroup of Diminutive Pancreatic Cysts Referred to as “Incipient IPMNs” (2014) (45)
Polymerase delta variants in RER colorectal tumours. (1995) (45)
Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds. (1991) (44)
Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors. (1992) (44)
Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer (2014) (43)
Role of stem-cell divisions in cancer risk (2017) (43)
CEST theranostics: label-free MR imaging of anticancer drugs (2016) (43)
Revisiting the tumorigenesis timeline with a data-driven generative model (2019) (42)
NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells (1994) (42)
Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation. (2019) (42)
Spore Coat Architecture of Clostridium novyi NT Spores (2007) (42)
Phosphorylation of β-Catenin at S33, S37, or T41 Can Occur in the Absence of Phosphorylation at T45 in Colon Cancer Cells (2003) (41)
Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q (2008) (40)
Genetic Testing-- Present and Future (2000) (40)
Going mad with Smads. (1999) (39)
Familial and sporadic pancreatic cancer share the same molecular pathogenesis (2015) (39)
Carrier detection in the Wiskott Aldrich syndrome. (1988) (39)
GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct. (2012) (39)
Monoallelic mutation analysis (MAMA) for identifying germline mutations (1995) (38)
Assessing tumors in living animals through measurement of urinary β-human chorionic gonadotropin (2000) (38)
14-3-3σ regulates B-cell homeostasis through stabilization of FOXO1 (2011) (38)
Molecular cloning of the N-terminus of GTBP. (1996) (38)
Identification and classification of p 53-regulated genes (1999) (37)
Assessing aneuploidy with repetitive element sequencing (2019) (37)
Targeting public neoantigens for cancer immunotherapy (2021) (36)
A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles (2011) (36)
Lack of association of human polyomaviruses with human brain tumors (2005) (36)
A subset of small nuclear ribonucleoprotein particle antigens is a component of the nuclear matrix. (1982) (36)
Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes (2015) (35)
High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma (2016) (35)
Phosphorylation of beta-catenin at S33, S37, or T41 can occur in the absence of phosphorylation at T45 in colon cancer cells. (2003) (35)
Diagnostic potential of tumor DNA from ovarian cyst fluid (2016) (35)
High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder (2016) (34)
Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs) (2018) (34)
A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts (2017) (34)
Mutational spectra and immunohistochemical analyses of p53 in human cancers. (1992) (33)
Colorectal cancer and the intersection between basic and clinical research. (1994) (33)
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 (2019) (33)
Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements. (2002) (33)
The gene for the APC-binding protein beta-catenin (CTNNB1) maps to chromosome 3p22, a region frequently altered in human malignancies. (1995) (33)
Similarity of the DNA-damage responsiveness and growth-suppressive properties of waf1/cip1 and gadd45. (1995) (32)
Discodermolide analogues as the chemical component of combination bacteriolytic therapy. (2005) (32)
DCC: a tumor suppressor gene expressed on the cell surface. (1992) (32)
Identification of microbial DNA in human cancer (2009) (32)
Noninvasive imaging of infection after treatment with tumor‐homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI (2013) (32)
Detection of Somatic TP53 Mutations in Tampons of Patients With High-Grade Serous Ovarian Cancer (2014) (31)
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints (2015) (31)
Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder. (2016) (30)
Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia (2011) (30)
Incidence and Distribution of UroSEEK Gene Panel in a Multi-institutional Cohort of Bladder Urothelial Carcinoma (2019) (30)
Programmed death-1 blockade in mismatch repair deficient cancer independent of tumor histology. (2016) (30)
PI3Kα Inhibitors That Inhibit Metastasis (2010) (30)
Rapid purification of DNA from agarose gels by centrifugation through a disposable plastic column. (1987) (30)
RNA-DNA hybridization in solution without DNA reannealing. (1977) (28)
Targeted sequencing of plasmacytoid urothelial carcinoma reveals frequent TERT promoter mutations. (2019) (28)
PAK1, a gene that can regulate p53 activity in yeast. (1995) (28)
Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects (2014) (27)
Conversion of diploidy to haploidy - Individuals susceptible to multigene disorders may now be spotted more easily. (2000) (27)
Differentiation of blast cells in acute nonlymphocytic leukemia. (1986) (27)
Mutation of an mutL homologue in a Navajo family with hereditary nonpolyposis colorectal cancer. (1994) (27)
Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder (2017) (26)
Systemic immunity against a murine colon tumor (CT‐26) produced by immunization with syngeneic cells expressing a transfected viral gene product (1989) (26)
Genetics. Please don't call it cloning! (2002) (25)
Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis. (2020) (25)
Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology (2019) (25)
Selected reaction monitoring approach for validating peptide biomarkers (2017) (24)
Direct Detection and Quantification of Neoantigens (2019) (24)
Structural effects of oncogenic PI3Kα mutations. (2010) (24)
Targeting loss of heterozygosity for cancer-specific immunotherapy (2021) (24)
Specific cellular stimulation in the primary immune response: a quantized model. (1982) (23)
Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis. (2012) (23)
Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model. (2016) (23)
A gene for neurofibromatosis 2 (1993) (22)
Cancer, crash sites, and the new genetics of neoplasia. (1999) (22)
Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma (2018) (22)
Somatic Mutations in CCK2R Alter Receptor Activity that Promote Oncogenic Phenotypes (2012) (22)
Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12. (1990) (22)
Gene amplification in cancer: a molecular cytogenetic approach. (1986) (22)
The Structure of a Human p 110 a / p 85 a Complex Elucidates the Effects of Oncogenic PI 3 K a Mutations (2007) (22)
Evidence of Inappropriate Application of Autologous Cartilage Transplantation Therapy in an Uncontrolled Environment (1999) (21)
Detection of low-frequency DNA variants by targeted sequencing of the Watson and Crick strands (2021) (21)
The anatomy of supercoiled loops in the Drosophila 7F locus. (1985) (21)
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers. (2005) (20)
Deep Learning in Radiology: Now the Real Work Begins. (2018) (20)
In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3–14.1 (1989) (20)
Genetic Alterations in Colorectal Tumors (1990) (19)
Musings on the theory that variation in cancer risk among tissues can be explained by the number of divisions of normal stem cells (2015) (19)
Increased phosphorylation rate of intermediate filaments during mitotic arrest. (1981) (19)
The colorectal cancer gene hunt: current findings. (1992) (19)
Thiazolidinedione-Based PI3Kα Inhibitors: An Analysis of Biochemical and Virtual Screening Methods (2011) (19)
Serial circulating tumor DNA (ctDNA) analysis as a prognostic marker and a real-time indicator of adjuvant chemotherapy (CT) efficacy in stage III colon cancer (CC). (2018) (18)
Alpha-1 adrenergic receptor antagonists for preventing acute respiratory distress syndrome and death from cytokine storm syndrome. (2020) (18)
Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design. (2017) (18)
Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity (2015) (18)
Circulating tumor DNA (ctDNA) as a marker of recurrence risk in stage II colon cancer (CC). (2014) (18)
Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection (2020) (18)
The Structure of a Human p110a/p85a Complex Elucidates the Effects of Oncogenic PI3Ka Mutations (2007) (18)
Continuous sampling as a pharmacokinetic tool (1977) (17)
Targeting the catecholamine-cytokine axis to prevent SARS-CoV-2 cytokine storm syndrome (2020) (17)
Less death in the dying (1997) (17)
The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality from COVID-19 (2020) (17)
Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes. (2001) (16)
Detection of genetic loss in tumors by representational difference analysis. (1994) (16)
Winning the War: Science Parkour (2012) (15)
The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations (2019) (15)
TCR β chain–directed bispecific antibodies for the treatment of T cell cancers (2021) (15)
Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations (2017) (15)
Effective expression of small interfering RNA in human cells (15)
Tumour suppressor genes. No room at the p53 inn. (1993) (14)
Advances in Brief Activating Mutations of the Noonan Syndrome-Associated SHP 2 / PTPN 11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia (2004) (14)
Potential role of circulating tumor DNA (ctDNA) in the early diagnosis and post-operative management of localised pancreatic cancer. (2017) (14)
On the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk (2017) (14)
Response to Comments on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers" (2007) (13)
Serial circulating tumor DNA (ctDNA) and recurrence risk in patients (pts) with resectable colorectal liver metastasis (CLM). (2016) (13)
Targeted deletion of Smad 4 shows it is required for transforming growth factor b and activin signaling in colorectal cancer cells (1998) (13)
Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design. (2010) (13)
Multicolor in vitro translation (2003) (13)
Divergence of primate ribosomal RNA genes as assayed by restriction enzyme analysis. (1980) (13)
PCR-based detection of two MspI polymorphic sites at D18S8. (1991) (13)
Mutant p 53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor , transforming growth factor 81 i ( carcinogenesis / tumor suppressor gene / beat shock protein ) (12)
What's mice got to do with it? (1996) (12)
The potential of circulating tumor DNA (ctDNA) to guide adjuvant chemotherapy decision making in locally advanced rectal cancer (LARC). (2017) (12)
Advances in Brief p 53 Mutation and MDM 2 Amplification in Human Soft Tissue Sarcomas 1 (2006) (12)
Tumour-suppressor genes. X-rays strike p53 again. (1994) (12)
Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase. (2004) (11)
The Xist RNA Gene Evolved in Eutherians by Pseudogenization of a Protein-Coding Gene (2006) (11)
Knudson's hypothesis and the TP53 revolution (2003) (11)
STATISTICAL METHODS FOR THE ANALYSIS OF CANCER GENOME SEQUENCING DATA (2007) (11)
Genetic testings for cancer: the surgeon's critical role. Familial colon cancer. (1999) (11)
The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality From COVID-19 (2021) (11)
Mammalian cells resistant to tumor suppressor genes. (1996) (10)
Design, synthesis and evaluation of new RDP inhibitors (2003) (10)
An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation (2019) (10)
Circulating tumor DNA (ctDNA) in nonmetastatic colorectal cancer (CRC): Potential role as a screening tool. (2015) (10)
Three dinucleotide repeat polymorphisms proximal to the D2S123 locus. (1994) (10)
Invasive aspergillosis. (1976) (10)
Erratum: Counting alleles reveals a connection between chromosome 18q loss and vascular invasion (Nature. Biotechnol. (2001) 19 (78-81)) (2001) (10)
SAM 1.1 and JOSH 4.4: two RFLPs within the human DCC gene. (1992) (10)
Association of α1-Blocker Receipt With 30-Day Mortality and Risk of Intensive Care Unit Admission Among Adults Hospitalized With Influenza or Pneumonia in Denmark (2021) (9)
Jass Carcinoma of the colon and rectum Adenocarcinoma (2006) (9)
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine–resistant cancer cells (2005) (9)
Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy (2018) (9)
EcoRI polymorphism within the GLI gene (chromosome 12q13.3-14.1). (1990) (9)
Genetic landscape of extreme responders with anaplastic oligodendroglioma (2017) (8)
Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase. (2012) (8)
Point mutations in human neoplasia (1988) (8)
Massively Parallel Sequencing of Esophageal Brushings Enables an Aneuploidy-Based Classification of Patients with Barrett's Esophagus. (2021) (8)
WISKOTT-ALDRICH SYNDROME (WAS) CARRIER DETECTION BY X-CHROMOSOME INACTIVATION ANALYSIS (1987) (8)
The potential of circulating tumor DNA (ctDNA) to reshape the design of clinical trials testing adjuvant therapy in patients with early stage cancers. (2016) (8)
Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens (2021) (8)
Tumor-Suppressor Genes (2003) (7)
Antisense RNA to the Putative Tumor Suppressor Gene “Deleted in Colorectal Cancer” Transforms Fibroblasts (1992) (7)
Advances in Brief p 53 Gene Mutations Occur in Combination with 17 p Allelic Deletions as Late Events in Colorectal Tumorigenesis 1 (2006) (7)
GENE AMPLIFICATION IN HUMAN GLIOMAS: 178 (1990) (7)
TEL and KIP 1 Define the Smallest Region of Deletions on 1 2 ~ 1 3 in Hematopoietic Malignancies (2000) (7)
Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer (2021) (7)
Abstract 451: The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints (2015) (6)
GNAS Codon 201 mutations are uncommon in Intraductal Papillary Neoplasms of the Bile Duct (2012) (6)
The Role of hPMS 1 and hPMS 2 in Predisposing to Colorectal Cancer 1 (2001) (6)
Breast and Colorectal Cancers The Consensus Coding Sequences of Human (2007) (6)
Cytogenetics and molecular genetics: their status and role in understanding the behavior of central nervous system neoplasms. (1990) (6)
Non-invasive detection of bladder cancer through the analysis of driver gene mutations and aneuploidy (2017) (5)
Candidate Tumor-Suppressor Genes (2003) (5)
Intraductal papillary mucinous neoplasm in a neonate with congenital hyperinsulinism and a de novo germline SKIL gene mutation. (2015) (5)
Circulating tumor DNA as a prognostic biomarker in early stage pancreatic cancer. (2018) (5)
Genetically defined subsets of human pancreatic cancer demonstrate unique in vitro chemosensitivity (2012) (5)
318MO Circulating tumour DNA (ctDNA) dynamics, CEA and sites of recurrence for the randomised DYNAMIC study: Adjuvant chemotherapy (ACT) guided by ctDNA analysis in stage II colon cancer (CC) (2022) (5)
Expression of p21waf1/cip1, mdm2 and p53 in vivo: analysis of cytological preparations (1996) (5)
Absence of germline prohibitin mutations in early-onset breast-cancer. (1993) (5)
BRCA1 and BRCA2 Genes (2003) (5)
Glioblastoma Multiforme An Integrated Genomic Analysis of Human (2010) (5)
Hidden Beauty: Exploring the Aesthetics of Medical Science (2013) (4)
Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma (2013) (4)
p53: a tumor suppressor hiding in plain sight (2019) (4)
Yeast artificial chromosome (YAC) vector cloning of the MYCN amplified domain in neuroblastomas. (1991) (4)
Tech.sight. Genetic testing--present and future. (2000) (4)
Classification of pancreatic cystic neoplasms using radiomic feature analysis is equivalent to an experienced academic radiologist: a step toward computer-augmented diagnostics for radiologists (2022) (4)
Circulating tumor DNA as a cancer biomarker (2008) (3)
14-3-3 sigma regulates B-cell homeostasis through stabilization of FOXO1 [Erratum: Proceedings of the National Academy of Sciences of the United States of America. 2011 Jan;108(4):1555-1560.] (2011) (3)
Response to Comments on “The Predictive Capacity of Personal Genome Sequencing” (2012) (3)
Erratum: 14-3-3s regulates B-cell homeostasis through stabilization of FOXO1 (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 4, (1555-1560) DOI: 10.1073/pnas.1017729108) (2011) (3)
The FELIX Project: Deep Networks To Detect Pancreatic Neoplasms (2022) (3)
Targeted Inactivation of p 53 in Human Cells Does Not Result in Aneuploidy 1 (2002) (3)
Through the Glass Lightly (1995) (3)
Reconstructing phylogenies of metastatic cancers (2016) (3)
Cancer. A gene for neurofibromatosis 2. (1993) (3)
Erratum to "Annotated normal CT data of the abdomen for deep learning: Challenges and strategies for implementation" [Diagn. Interv. Imaging. 101 (2020) 35-44]. (2020) (2)
Abstracts of the 32nd Annual American Cytogenetics Conference (1995) (2)
Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of DMXAA in human and mouse plasma. (2007) (2)
Material for The Antisense Transcriptomes of Human Cells (2008) (2)
Abstract 4137: Clonal evolution defines the natural history of metastatic pancreatic cancer (2015) (2)
The Genetic Evolution of Melanoma. (2016) (2)
Can Cytogenetic and Molecular Genetic Analyses of Malignant Human Gliomas Be Used Yet To Supplement Conventional Classification Schemes (1989) (2)
Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs ( NSAIDs ) in colon cancer cells (2004) (2)
Advances in Brief Inherited p 53 Gene Mutations in Breast Cancer 1 (2006) (2)
The treatment of tumors (2004) (2)
HindIII polymorphism in the DCC gene. (1991) (2)
Necessity Is the Mother of Invention: The Development of Digital Genomics. (2016) (2)
Insertion/Deletion Polymorphism and Other Restriction Fragment Length Polymorphisms in the MCC Gene (1992) (2)
Abstract 20: Whole exome sequencing of aristolochic acid induced upper urothelial carcinomas. (2012) (2)
A pooled analysis of multicenter cohort studies of post-surgery circulating tumor DNA (ctDNA) in early stage colorectal cancer (CRC). (2019) (2)
DNA Repair Pathway Genes (2003) (2)
PAK 1 , a gene that can regulate p 53 activity in yeast ( tumor suppressor / transactivation / posttranslational modification / phosphorylation ) (2005) (2)
Author response: Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection (2021) (2)
Massively parallel sequencing (MPS) of circulating DNA in patients with metastatic colorectal cancer (mCRC): Prognostic significance and early changes during chemotherapy (CT). (2013) (2)
PRINT: A Protein Bioconjugation Method with Exquisite N-terminal Specificity (2015) (2)
Structural basis of nSH 2 regulation and lipid binding in PI 3 Kα (2014) (2)
TCR-mimic bispecific antibodies to target the HIV-1 reservoir (2022) (1)
Software for Assessing aneuploidy with repetitive element sequencing (2020) (1)
Targeting MHC-linked wild type p53 with TCR mimic single chain diabody for cancer immunotherapy. (2019) (1)
Testing the accuracy of mutation detection for the prevention of ovarian neoplasia: The TAMPON study (2014) (1)
Mononucleotide Repeat Sequence Variability in Mismatch Repair-deficient Cancers 1 (2001) (1)
Hypoxia in a tumor may promote emergence of clones with p53 gene mutation (1996) (1)
1124 A MULTI-MODALITY TEST TO GUIDE THE MANAGEMENT OF PATIENTS WITH PANCREATIC CYSTS (2019) (1)
Author Correction: Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers (2021) (1)
An analysis of genetic heterogeneity in untreated cancers (2019) (1)
Advances in Brief Mutational Analysis of the APC / / 3-Catenin / Tcf Pathway in Colorectal Cancer 1 (2006) (1)
Alpha-1 adrenergic receptor antagonists prevent acute respiratory distress syndrome and death: implications for Coronavirus disease 2019 (2020) (1)
Advances in Brief X-Linked Inhibitor of Apoptosis Protein ( XIAP ) Is a Nonredundant Modulator of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand ( TRAIL )-Mediated Apoptosis in Human Cancer Cells (2004) (1)
ET-58THE GENETICALLY ENGINEERED CLOSTRIDIUM NOVYI-NT IS EFFICACIOUS IN THE TREATMENT OF INTRACRANIAL GLIOBLASTOMAS. (2014) (1)
SUPERCOILED LOOPS AND TRANSCRIBING GENES (1982) (1)
p2! Is Necessary for the p53-mediated G, Arrest in Human Cancer Cells' (2006) (1)
Use of TCR-mimic bispecific antibodies against pMHC-II for monitoring antigen processing and redirecting cytolytic effector cells (2020) (1)
Assessment of the size window of tumor vascular permeability using dextran-based CEST MRI (2013) (1)
Correction to: Performance of novel non-invasive urine assay UroSEEK in cohorts of equivocal urine cytology (2022) (1)
Abstracts Accepted for Plenary & Parallel Sessions 55th Annual Cancer Symposium Society of Surgical Oncology March 14–17, 2002 Denver, CO (2007) (1)
Advances in Brief Cell Surface Tumor Endothelial Markers Are Conserved in Mice and Humans 1 (2001) (1)
13 Chromosomes and gene amplification in malignant human gliomas (MHG) (1987) (1)
Detection of tumor-derived DNA with combination Pap smear and plasma testing in women with primary ovarian cancer: A potential screening test on the horizon? (2017) (1)
mRNA expression of L-type calcium channels increases in colon cancer (1998) (1)
Abstract 2225: The molecular architecture of p85α as determined by SAXS and chemical cross-linking. (2013) (1)
Abstract IA17: Non-invasive detection of somatic mutations in the management of CRC (2017) (1)
An interview with Bert Vogelstein and Kenneth Kinzler. (2015) (1)
Abstract 1125: Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancers (2015) (1)
The Zinc Finger Protein GLI Transforms Primary Cells in Cooperation with Adenovirus ElA (2004) (1)
Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 (2019) (1)
Durable Responses to PD-1 Blockade in Mismatch-Repair Deficient Cancers, Independent of Tissue Origin (2017) (1)
Non-invasive detection of upper tract urothelial carcinomas through the analysis of driver gene mutations and aneuploidy in urine (2017) (1)
Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma (2018) (1)
Abstract 2628: Genome-wide sequencing identifiesATMas a pancreatic cancer susceptibility gene (2012) (1)
Analysis of masked mutations in (2016) (0)
RESPONSE: Tumor Location and Detection of K-Ras Mutations in Stool From Colorectal Cancer Patients (2003) (0)
identifying cancer patients from GC-patterned fragment ends of cell-free DNA (2022) (0)
597 Molecular Markers Help Define Cyst Type in the Pancreas: An International, Multicenter Study of Over 300 Cysts (2016) (0)
The APC Gene (2003) (0)
UROSEEK: A NOVEL NON‐INVASIVE MOLECULAR METHOD FOR EARLY DETECTION OF BLADDER CANCER: MP65‐13 (2018) (0)
Crystal Structure of PI3Kalpha in complex with fragments 12 and 15 (2017) (0)
PIK3CA gene mutations in human cancers (2005) (0)
TheGLIGeneEncodes a Nuclear Protein WhichBindsSpecific Sequences intheHumanGenome (1990) (0)
14 Renaturation gel analysis of amplified DNA sequences (1987) (0)
Cancer in Predisposing to Colorectal hPMS 2 and hPMS 1 The Role of Updated Version (2001) (0)
Circulating Tumour DNA Analysis Informing Adjuvant Chemotherapy in Stage II Colon Cancer (DYNAMIC Trial): Statistical Analysis Plan (2021) (0)
Coli) Gene in Patients and the APC (Adenomatous Polyposis FAP (Familial Polyposis Coli) in Sporadic Colorectal Tumors (2006) (0)
Transcriptional regulation of basic fibroblast growth factor gene by p 53 in human glioblastoma and hepatocellular carcinoma cells ( mutant p 53 / tumor progression / brain tumor ) (0)
Author Correction: Targeting public neoantigens for cancer immunotherapy (2021) (0)
Abstract NG06: The Trojan Horse Strategy: Packaging chemotherapeutics can help alleviate toxicity (2015) (0)
Author response: Diagnostic potential of tumor DNA from ovarian cyst fluid (2016) (0)
A retrospective clinical study supporting the rationale for trials of Alpha-1 Adrenoreceptor Antagonists to prevent cytokine storm and severe COVID-19 (2020) (0)
Advances in Brief Amplification of Cyclin Genes in Colorectal Carcinomas 1 (2006) (0)
Supplemental Information Genomic Sequencing Identi fi es ELF 3 as a Driver of Ampullary Carcinoma (0)
Abstract B004: sCD-3BP: An MCT-1-“gated” therapeutic for pancreatic adenocarcinoma (2022) (0)
Figure 5.5, [p53 functional motifs. Sequences of...]. (2000) (0)
The rapid and highly parallel identification of antibodies with defined biological activities by SLISY (2023) (0)
Advances in Brief p 2 ! Is Necessary for the p 53-mediated G , Arrest in Human Cancer Cells ' (2006) (0)
Correction: Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma (2017) (0)
Limits to the Human Cancer Genome Project ? (0)
University of Southern Denmark Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers (2018) (0)
629 Targeting a shared TP53 neoantigen with bispecific T cell retargeting antibody (2020) (0)
Supplement to: cancer associated mutations in non-cancer associated endometriosis (2017) (0)
Use of experimentally constructed haplotypes in gene mapping studies of hereditary cancers (2001) (0)
NIH Grant Application Testing the effects of genetic variations using MINIME technology (1999) (0)
Abstract LB095: Hybrid TCR-CAR design surpasses conventional CARs and patient-derived TCRs in targeting an ultra-low-density neoantigen (2023) (0)
Immunogenicity of a non-class I MHC expressing murine tumor transfected with the influenza virus hemagglutinin or murine interleukin-2 genes (2005) (0)
Epigenetic Profiling and Epigenetic Therapy in Cancer (2008) (0)
AMERICAN ASSOCIATION FOR CANCER RESEARCH SCIENTIFIC CONFERENCES (1995) (0)
Genetic landscape of extreme responders with anaplastic oligodendroglioma: NRG Oncology/RTOG 9402. (2016) (0)
The interaction of beta-catenin, TCF-4, and APC leading to the prevention of cancer (1998) (0)
NF1 and NF2 Genes (2003) (0)
Mitochondrial suitable as a tumor marker mutations that affect only one base pair (1999) (0)
Abstract PR02: Targeting PI3K: The PIP2 binding site (2015) (0)
UROSEEK: A NOVEL NON‐INVASIVE MOLECULAR ASSAY FOR SURVEILLANCE OF BLADDER CANCER: MP65‐14 (2018) (0)
Pathogenesis of Adenocarcinoma in Peutz-Jeghers Syndrome1 (2006) (0)
Crystal Structure of PI3Kalpha in complex with diC4-PIP2 (2014) (0)
Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 (Journal for Immuno Therapy of Cancer (2019) 7 (40) DOI: 10.1186/s40425-018-0492-x) (2019) (0)
1213 Hydrophobic interactions underlie recognition of a KRAS G12V neoantigen by a TCR-mimic antibody (2022) (0)
Series analysis method of gene expression (1996) (0)
Abstract IA05: ctDNA and MRD in colorectal cancer: Time to reinvent adjuvant clinical trials (2020) (0)
Abstract 2839: Specific mutant tumor DNA can be detected in ovarian cystic fluid of an unknown ovarian tumor cyst (2015) (0)
Families Evaluable by Linkage (2007) (0)
Abstract NG01: Accumulation of somatic mutations in normal and cancerous tissues with age (2016) (0)
Ewing et al. Suppl. Fig. 3 (2015) (0)
Author response: Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer (2020) (0)
Abstract PL01-03: Earlier detection as a key to lower cancer death rates (2017) (0)
Abstract 2374: Reconstructing the evolutionary history of metastatic cancers (2016) (0)
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs (2021) (0)
Seq-ing the SINEs of Central Nervous System Tumors in Cerebrospinal Fluid DNA (2022) (0)
Huang Mutations α Effects of Oncogenic PI 3 K Complex Elucidates the α / p 85 α The Structure of a Human p 110 (2013) (0)
Abstract 2951: Vitamin C is selectively toxic to cancer cells harboring KRAS or BRAF mutations by targeting GAPDH (2014) (0)
Identifying Markers for Pancreatic Cancer by Gene Expression 1 (2005) (0)
UvA-DARE ( Digital Academic Repository ) APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis (1998) (0)
ALBERT J. WONG*t, JOHN M. RUPPERT*, SANDRA H. BIGNERt, CARL H. GRZESCHIK?, PETER A. HUMPHREYt, (2016) (0)
Familial and sporadic pancreatic cancer share the same molecular pathogenesis (2014) (0)
Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules. (2023) (0)
Crystal Structure of PI3Kalpha in complex with fragment 10 (2017) (0)
IL-2 AUGMENTS IMMTAC-DEPENDENT T CELL ACTIVATION AND TUMOUR CELL KILLING TARGETING A SHARED TP53 NEOANTIGEN WITH BISPECIFIC T CELL RETARGETING ANTIBODY (2020) (0)
Circulating tumor DNA reflects therapy response in colorectal cancer (2008) (0)
Waf1 anti-tumoral (1994) (0)
The INK4A Locus and the p16 INK4A and p19 ARF Genes (2003) (0)
catastrophe after DNA damage (1999) (0)
Abstract 985: Dissecting PI3K-AKT pathway by phosphoproteomic profiling of PIK3CA knock-in mutants (2012) (0)
Supplementary Materials for Variation in cancer incidence among tissues can be explained by the number of stem cell divisions (2015) (0)
UroSEEK signature in invasive bladder cancer (2018) (0)
Procede et compositions de detection et d'enumeration de variations genetiques (2004) (0)
The Big Data cancer results are reported in Bert (0)
The p53 Gene (2003) (0)
Dna sequence amplification in a colon carcinoma cell line resistant to mitoxantrone (1986) (0)
Amplification of Cyclin Genes in Colorectal Carcinomas1 (2006) (0)
Title: Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer (2014) (0)
Advances in Brief HMSH 2 Mutations in Hereditary Nonpolyposis Colorectal Cancer Kindreds 1 (2006) (0)
Cancer Therapy : Preclinical Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer (2014) (0)
X-Chromosome Clonal Analysis Using Recombinant DNA Probes from the Updated (2006) (0)
Precancerous neoplastic cells can move through the pancreatic ductal system (2018) (0)
Somatic Cell Genetic Studies of Tumorigenesis (2003) (0)
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin (2009) (0)
A method for determining mammal nucleic acids from stool samples and reagents required for this (1993) (0)
Assignment of the Human p27Kipl Gene to 12pl3 and Its Analysis in Leukemias1 (1995) (0)
Exomic sequencing of pancreatic neuroendocrine tumors: Detection of alterations in chromatin remodeling and mTOR pathway genes. (2011) (0)
Inherited and somatic mutations of the APC gene in human colorectal cancer (1992) (0)
A apc mutation, which is associated with familial colon cancer at ashkenazi jews (1998) (0)
Abstract 127: The genomic landscapes of inflammatory bowel disease-associated colorectal cancers (2016) (0)
CANCER : THE INTERFACE BETWEEN BASIC AND APPLIED RESEARCH American Association for Cancer Research Conference Baltimore , WA ; November 5-8 , 1995 (2007) (0)
A simplified system for herstelliung of recombinant adenoviruses (1999) (0)
Genome Maps: 11 The Human Genome (2001) (0)
Use of experimentally constructed haplotypes in gene mapping studies of hereditary cancers (2001) (0)
Abstract LB-326: Structural basis of lipid-binding and regulation in PI3Kα (2014) (0)
Abstract LB-054: Normal stem cell divisions, cancer incidence, and driver gene mutations (2015) (0)
Dissecting the specificity of a TCR-mimic antibody targeting TP53 R175H mutation-derived neoantigen (2020) (0)
Method for generation of fast-mutating yeast (2001) (0)
Bugging tumours to deliver anticancer agents with anaerobic bacteria (2007) (0)
Identification of Somatically Acquired Gene Mutations In the Kineome and Exome In CLL (2010) (0)
Mutation-based detection of molecular tumor margins in colorectal liver metastasis. (2010) (0)
Ewing et al. Suppl. Data 1 (2015) (0)
Retinoblastoma—A Paradigm for Tumor-Suppressor Gene Function (2003) (0)
Circulating Tumor DNA as a Prognostic Marker in Stage III Colon Cancer-Reply. (2020) (0)
Genetic Basis for Tumor Development (2003) (0)
Analysis of Circulating DNA Serial Assessment of Human Tumor Burdens in Mice by the (2007) (0)
Methods and compositions for gene therapy and strengthening the immune system. (1991) (0)
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha (2009) (0)
Yac clones comprising 55 mb of dna at the fap locus 5q21 in six contigs allow localisation of polymorphic markers and candidate tumour suppressor genes (1991) (0)
In vitro High-Resolution Architecture and Structural Dynamics of Bacterial Systems (2010) (0)
Advances in Brief Assignment of the Human p 27 Kipl Gene to 12 pl 3 and Its Analysis in Leukemias 1 (2006) (0)
Converting cancer genes into killer genes (gene therapyyoncogeneytumor suppressor geneyp53) (1996) (0)
Reconstructing robust phylogenies of metastatic cancers (2015) (0)
Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome (2018) (0)
Human Cancer Biology Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis (2011) (0)
Humanp53andCDC2HsGenesCombineToInhibit the Proliferation ofSaccharomyces cerevisiae (1992) (0)
Abstract PR3: Exome sequencing of head and neck squamous cell carcinoma reveals a higher frequency of mutations in TP53 among African Americans (2011) (0)
Science Translational Medicine Podcast: 28 March 2012 (2012) (0)
Bacteriolytic combination therapy for the treatment of tumors (2002) (0)
Abstract DL01-01: Cancer Genomes and their Implications for Early Detection (2013) (0)
Abstracts of the 33rd Annual American Cytogenetics Conference (1995) (0)
Wanted: cancer boss (2006) (0)
Cloning and analysis of a 1.2 mb N-myc amplicon from a human neuroblastoma (1993) (0)
Subject Index, Vol. 71 1995 (1995) (0)
Modifications to the structure of the EGF receptor gene in human glioma (1990) (0)
Crystal Structure of p110alpha in complex with niSH2 of p85alpha (2014) (0)
Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects (2014) (0)
Identifying Markers for Pancreatic Cancer by Gene (2017) (0)
963 Exploring the inherent CEST MRI signal of anticancer drug gemcitabine (2013) (0)
Oral history of Bert Vogelstein (1999) (0)
Report of the second international workshop on human chromosome 5 mapping: consensus genetic map. (1992) (0)
44 MASSIVELY PARALLEL SEQUENCING OF ESOPHAGEAL BRUSHINGS ENABLES AN ANEUPLOIDY-BASED CLASSIFICATION OF PATIENTS WITH BARRETT'S ESOPHAGUS (0)
Isaac Kinde Endometrial Cancers Evaluation of DNA from the Papanicolaou Test to Detect Ovarian (2013) (0)
Consensus sequences coding for human breast and colorectal cancers (2007) (0)
p53Functions as a CellCycleControl Protein inOsteosarcomas (1990) (0)
Triplet expansions (1993) (0)
Jihye Yun Pathway Mutations in Tumor Cells KRAS Glucose Deprivation Contributes to the Development of (2013) (0)
Detecting the failure of the wild-type p53 gene (1990) (0)
MORPHOLOGIC CHARACTERISTICS OF MALIGNANT HUMAN GLIOMAS (MHG) WITH GENE AMPLIFICATION: 123 (1987) (0)
Improved methods of beaming (2006) (0)
Abstract C60: Vitamin C inhibits the survival and growth of colorectal cancer cells with KRAS or BRAF mutations (2013) (0)
Abstract LB-257: Profiling the effects of IDH1 and IDH2 mutants on the glioma cell metabolome (2011) (0)
Cancer genomes and their implications for understanding and managing cancer. (2009) (0)
Presentation of the William Beaumont Prize to Bert Vogelstein, M.D. (1997) (0)
Tissue specific pulsed field gel fragment patterns in a 700 KB domain surrounding GLI (1989) (0)
Structural basis for the effects of PI3Kalpha oncogenic mutations (2008) (0)
Bert Vogelstein explains cancer and the unavoidable replicative mutations (2017) (0)
Leary Patients with Whole-Genome Sequencing Detection of Chromosomal Alterations in the Circulation of Cancer (2012) (0)
Interview with Bert Vogelstein, December 22, 1999 (2015) (0)
Multi-Probe Investigation of Proteomic Structure of Pathogens (2008) (0)
1197 Optimizing a T cell-engaging bispecific antibody targeting the highly recurrent p53 R175H neoantigen via affinity maturation (2022) (0)
Advances in Brief WAF 1 / CIP 1 Is Induced in / ? 53-mediated G ! Arrest and Apoptosis 1 (2006) (0)
2777 Lavage of the uterine cavity for early and differential diagnosis of serous ovarian cancer (2015) (0)
Somatic mutations in PI 3 K α : structural basis for the enzyme activation and drug design (2010) (0)
Advances in Brief Pathogenesis of Adenocarcinoma in Peutz-Jeghers Syndrome 1 (2006) (0)
Non-invasive detection of bladder cancer through the analysis of driver gene 1 mutations and aneuploidy 2 3 (2017) (0)

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