Beverly L. Davidson
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Beverly L. Davidsonbiology Degrees
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Molecular Biology
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Neuroscience
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Biochemistry
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Biology
Beverly L. Davidson's Degrees
- PhD Biochemistry University of Iowa
- Bachelors Biology University of Iowa
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(Suggest an Edit or Addition)Beverly L. Davidson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- RNA polymerase III transcribes human microRNAs (2006) (1451)
- Transvascular delivery of small interfering RNA to the central nervous system (2007) (1109)
- siRNA-mediated gene silencing in vitro and in vivo (2002) (917)
- Current prospects for RNA interference-based therapies (2011) (699)
- RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia (2004) (677)
- RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. (2005) (676)
- Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. (1998) (670)
- Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. (2000) (645)
- The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease (2008) (642)
- Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy (1997) (636)
- Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi (2008) (596)
- A model system for in vivo gene transfer into the central nervous system using an adenoviral vector (1993) (590)
- Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. (1996) (497)
- Allele-specific silencing of dominant disease genes (2003) (404)
- Structure and activity of putative intronic miRNA promoters. (2010) (389)
- Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. (2003) (379)
- Identification of PDGFR as a receptor for AAV-5 transduction (2003) (369)
- Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. (2009) (349)
- Progressive Muscular Dystrophy in α-Sarcoglycan–deficient Mice (1998) (341)
- Lysosomal storage diseases (2018) (335)
- Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice. (2009) (328)
- MicroRNAs Potentiate Neural Development (2009) (321)
- Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer (2000) (317)
- Viral vectors for gene delivery to the nervous system (2003) (313)
- Complexes of Adenovirus with Polycationic Polymers and Cationic Lipids Increase the Efficiency of Gene Transfer in Vitro and in Vivo* (1997) (286)
- Functional Repair of Human Donor Lungs by IL-10 Gene Therapy (2009) (281)
- Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. (2001) (280)
- Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain (1995) (244)
- CHIP Suppresses Polyglutamine Aggregation and Toxicity In Vitro and In Vivo (2005) (236)
- Clarifying lysosomal storage diseases (2011) (224)
- Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease. (2011) (211)
- Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E. (2000) (206)
- CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo (2017) (205)
- Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size (2002) (202)
- Minimum Requirements for Efficient Transduction of Dividing and Nondividing Cells by Feline Immunodeficiency Virus Vectors (1999) (201)
- In vivo targeting of SF/HGF and c‐met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis (2002) (198)
- Adenoviral-mediated gene transfer to rabbit synovium in vivo. (1993) (198)
- Behavioral and Cellular Protection of Rat Dopaminergic Neurons by an Adenoviral Vector Encoding Glial Cell Line-Derived Neurotrophic Factor (1998) (194)
- In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector. (1994) (187)
- Adenoviral-Mediated Transfer of the TNF-Related Apoptosis-Inducing Ligand/Apo-2 Ligand Gene Induces Tumor Cell Apoptosis1 (2000) (187)
- Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) (176)
- Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. (1994) (173)
- Gene therapy for lysosomal storage diseases. (1998) (172)
- Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. (2004) (167)
- Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect. (1999) (166)
- Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury (1997) (165)
- Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors (2002) (163)
- Recombinant Human Adenovirus: Targeting to the Human Transferrin Receptor Improves Gene Transfer to Brain Microcapillary Endothelium (2000) (161)
- The HIV Tat protein transduction domain improves the biodistribution of β-glucuronidase expressed from recombinant viral vectors (2001) (159)
- Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice (2010) (159)
- Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs. (2008) (158)
- The importance of TGF-beta in murine visceral leishmaniasis. (1998) (157)
- Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo. (2000) (152)
- Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors (2000) (151)
- In Vivo Gene Transfer Using a Nonprimate Lentiviral Vector Pseudotyped with Ross River Virus Glycoproteins (2002) (150)
- In vivo SELEX for Identification of Brain-penetrating Aptamers (2013) (150)
- Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis. (2008) (150)
- Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes (2018) (146)
- Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes (2015) (145)
- Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain (2013) (142)
- Adenosine deamination in human transcripts generates novel microRNA binding sites (2009) (139)
- Expression of Escherichia coli β-Galactosidase and Rat HPRT in the CNS of Macaca mulatta Following Adenoviral Mediated Gene Transfer (1994) (138)
- A Mouse Model of Classical Late-Infantile Neuronal Ceroid Lipofuscinosis Based on Targeted Disruption of the CLN2 Gene Results in a Loss of Tripeptidyl-Peptidase I Activity and Progressive Neurodegeneration (2004) (138)
- Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat (1999) (132)
- Molecular medicine for the brain: silencing of disease genes with RNA interference (2004) (132)
- Functional rescue of the sarcoglycan complex in the BIO 14.6 hamster using delta-sarcoglycan gene transfer. (1998) (130)
- Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries (2018) (130)
- Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue. (1995) (129)
- Widespread establishment and regulatory impact of Alu exons in human genes (2011) (128)
- Lentivirus Vectors Pseudotyped with Filoviral Envelope Glycoproteins Transduce Airway Epithelia from the Apical Surface Independently of Folate Receptor Alpha (2003) (128)
- Intracranial Delivery of CLN2 Reduces Brain Pathology in a Mouse Model of Classical Late Infantile Neuronal Ceroid Lipofuscinosis (2006) (126)
- Functional Correction of CNS Phenotypes in a Lysosomal Storage Disease Model Using Adeno-Associated Virus Type 4 Vectors (2005) (125)
- Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. (1995) (121)
- The transcription factor ATF4 promotes skeletal myofiber atrophy during fasting. (2010) (116)
- Pulmonary inflammation induced by incomplete or inactivated adenoviral particles. (1995) (114)
- Silencing Primary Dystonia: Lentiviral-Mediated RNA Interference Therapy for DYT1 Dystonia (2005) (114)
- Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors. (2003) (112)
- Diverse Splicing Patterns of Exonized Alu Elements in Human Tissues (2008) (112)
- Altered vascular function after adenovirus-mediated overexpression of endothelial nitric oxide synthase. (1997) (108)
- Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood-brain barrier disruption. (1995) (108)
- Gene expression from recombinant viral vectors in the central nervous system after blood-brain barrier disruption. (1995) (108)
- Influence of Cell Polarity on Retrovirus-Mediated Gene Transfer to Differentiated Human Airway Epithelia (1998) (108)
- AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease (2015) (106)
- Treatment of Experimental Human Mesothelioma Using Adenovirus Transfer of the Herpes Simplex Thymidine Kinase Gene (1995) (105)
- Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina. (2003) (105)
- Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice. (1998) (103)
- Unique molecular signatures of disease brain endothelia provide a novel site for CNS-directed enzyme therapy (2009) (102)
- Batten disease: evaluation of CLN3 mutations on protein localization and function. (2000) (102)
- Phenotype correction in retinal pigment epithelium in murine mucopolysaccharidosis VII by adenovirus-mediated gene transfer. (1995) (101)
- A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man. (1986) (99)
- Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain. (1998) (99)
- Efficient Liver-specific Deletion of a Floxed Human Angiotensinogen Transgene by Adenoviral Delivery of Cre Recombinasein Vivo * (1999) (98)
- SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation (2013) (96)
- Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector. (1995) (95)
- Toward therapy for DYT1 dystonia: Allele‐specific silencing of mutant TorsinA (2003) (94)
- Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts. (1989) (90)
- In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors. (2001) (90)
- Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C (1999) (89)
- Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model. (2017) (88)
- Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS (2005) (88)
- Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing. (1998) (87)
- Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. (2008) (86)
- Rho GTPases Modulate Entry of Ebola Virus and Vesicular Stomatitis Virus Pseudotyped Vectors (2009) (85)
- Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. (2005) (85)
- Proliferation induced by keratinocyte growth factor enhances in vivo retroviral-mediated gene transfer to mouse hepatocytes. (1996) (85)
- Attenuation of Ischemic Inflammatory Response in Mouse Brain Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist (1998) (84)
- A Chimeric Type 2 Adenovirus Vector with a Type 17 Fiber Enhances Gene Transfer to Human Airway Epithelia (1999) (83)
- Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses (2008) (83)
- Systemic and Central Nervous System Correction of Lysosomal Storage in Mucopolysaccharidosis Type VII Mice (1999) (81)
- Adenovirus-mediated gene transfer to normal and atherosclerotic arteries. A novel approach. (1995) (80)
- Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease. (2016) (79)
- Viral-mediated gene transfer to mouse primary neural progenitor cells. (2002) (79)
- Intrapericardial administration of adenovirus for gene transfer. (1997) (76)
- Systemic Hyperosmolality Improves β-Glucuronidase Distribution and Pathology in Murine MPS VII Brain Following Intraventricular Gene Transfer (1999) (76)
- Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease. (2011) (76)
- Direct plasmid mediated transfection of adult murine brain cells in vivo using cationic liposomes (1994) (75)
- Selective Gene Transfer to Key Cardiovascular Regions of the Brain: Comparison of Two Viral Vector Systems (2002) (75)
- Factors that influence stability of recombinant adenoviral preparations for human gene therapy. (1998) (74)
- Adenovirus-mediated over-expression of Interleukin-1 receptor antagonist reduces susceptibility to excitotoxic brain injury in perinatal rats (1996) (74)
- Retinal Pathology and Function in a Cln3 Knockout Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease) (2002) (73)
- Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. (2007) (73)
- Identification of 17 independent mutations responsible for human hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. (1991) (73)
- Timing of therapeutic intervention determines functional and survival outcomes in a mouse model of late infantile batten disease. (2007) (72)
- Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease. (2013) (71)
- Human Coronavirus 229E Infects Polarized Airway Epithelia from the Apical Surface (2000) (71)
- Vascular Cell Adhesion Molecule-1 Augments Adenovirus-Mediated Gene Transfer (2001) (70)
- Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells. (1994) (69)
- RNAi medicine for the brain: progresses and challenges. (2011) (68)
- What does it take to bind CAR? (2005) (68)
- Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells. (1999) (68)
- Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice. (2013) (67)
- Connecdenn, A Novel DENN Domain-Containing Protein of Neuronal Clathrin-Coated Vesicles Functioning in Synaptic Vesicle Endocytosis (2006) (67)
- Viral-mediated delivery of the late-infantile neuronal ceroid lipofuscinosis gene, TPP-I to the mouse central nervous system (2003) (65)
- PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo (2016) (65)
- Dicer is required for proliferation, viability, migration and differentiation in corticoneurogenesis (2012) (65)
- Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy. (2014) (64)
- Functional microRNAs and target sites are created by lineage-specific transposition. (2014) (62)
- Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue in mice. (1998) (62)
- Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. (2013) (61)
- Gene therapy for ALS: A review (2021) (61)
- Gene transfer to cerebral blood vessels after subarachnoid hemorrhage. (1997) (60)
- A Knock-In Reporter Model of Batten Disease (2007) (60)
- Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain. (2004) (58)
- Impact of human interleukin-10 on vector-induced inflammation and early graft function in rat lung transplantation. (2003) (57)
- Huntington's disease: progress toward effective disease-modifying treatments and a cure. (2010) (57)
- CLN3 Loss Disturbs Membrane Microdomain Properties and Protein Transport in Brain Endothelial Cells (2013) (56)
- Adenovirus-mediated transgene expression in nonhuman primate brain. (1999) (55)
- Membrane topology of CLN3, the protein underlying Batten disease (2003) (54)
- Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors. (2002) (54)
- Gene transfer of calcitonin gene-related peptide to cerebral arteries. (2000) (54)
- MiR-34a Represses Numbl in Murine Neural Progenitor Cells and Antagonizes Neuronal Differentiation (2012) (53)
- Evolution of alternative splicing in primate brain transcriptomes. (2010) (53)
- Poly-L-lysine improves gene transfer with adenovirus formulated in PLGA microspheres (1999) (53)
- The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brain. (2005) (53)
- Augmented adenovirus-mediated gene transfer to atherosclerotic vessels. (1997) (53)
- RNA Interference: A Tool for Querying Nervous System Function and an Emerging Therapy (2007) (52)
- RNAi therapeutics for CNS disorders (2010) (51)
- Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease. (2009) (51)
- Nonallele specific silencing of ataxin-7 improves disease phenotypes in a mouse model of SCA7. (2014) (51)
- Inflammatory responses and their impact on β-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus (1999) (50)
- Integration Site Choice of a Feline Immunodeficiency Virus Vector (2006) (50)
- Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheek pouch carcinoma cells. (1997) (50)
- Recombinant Adenovirus: A Gene Transfer Vector for Study and Treatment of CNS Diseases (1997) (49)
- Gene therapy for amyotrophic lateral sclerosis and other motor neuron diseases. (2000) (49)
- Changes in expression of NMDA-NR1 receptor subunits in the rostral ventromedial medulla modulate pain behaviors (2010) (48)
- Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP (2016) (48)
- Viral Vectors for Gene Transfer (2018) (47)
- siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse (2012) (47)
- Early adenovirus-mediated gene transfer effectively prevents muscular dystrophy in alpha-sarcoglycan-deficient mice (2000) (46)
- Retinal transduction profiles by high-capacity viral vectors (2014) (45)
- Cationic polymer and lipids enhance adenovirus-mediated gene transfer to rabbit carotid artery. (1998) (45)
- Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro. (2013) (44)
- Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease. (2012) (44)
- Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects. (1991) (43)
- Human hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular defect in a patient with gout (HPRTAshville). (1989) (42)
- RNAi or overexpression: Alternative therapies for Spinocerebellar Ataxia Type 1 (2013) (42)
- Adenosine deaminase deficiency with normal immune function. An acidic enzyme mutation. (1983) (41)
- Viral delivery of recombinant short hairpin RNAs. (2005) (41)
- Infection of Human Airway Epithelia with H1N1, H2N2, and H3N2 Influenza A Virus Strains (2001) (40)
- Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia. (1997) (39)
- Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. (2017) (39)
- Ultrasound-Guided Gene Transfer to Hepatocytes in utero (1998) (39)
- Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector (1998) (38)
- RNA Interference-Based Therapy for Spinocerebellar Ataxia Type 7 Retinal Degeneration (2014) (38)
- Gene Transfer to Rodent Brain with Recombinant Adenoviral Vectors: Effects of Infusion Parameters, Infectious Titer, and Virus Concentration on Transduction Volume (1998) (38)
- RNAi prevents and reverses phenotypes induced by mutant human ataxin‐1 (2016) (38)
- AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity. (2019) (38)
- Defining the pathway for Tat-mediated delivery of beta-glucuronidase in cultured cells and MPS VII mice. (2005) (38)
- Towards Therapy Using RNA Interference (2004) (38)
- Generation of hairpin-based RNAi vectors for biological and therapeutic application. (2012) (38)
- Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: evidence for prolonged stability and activity of the transgene in liver. (1996) (38)
- Altered Purkinje cell miRNA expression and SCA1 pathogenesis (2013) (36)
- RNAi: a potential therapy for the dominantly inherited nucleotide repeat diseases (2006) (36)
- Expression of human interleukin-1 receptor antagonist in mouse lungs using a recombinant adenovirus: effects on vector-induced inflammation. (1995) (36)
- Large-scale analysis of exonized mammalian-wide interspersed repeats in primate genomes. (2009) (35)
- Adeno-associated virus type 5 reduces learning deficits and restores glutamate receptor subunit levels in MPS VII mice CNS. (2007) (35)
- Adenovirus-Mediated Gene Therapy for Head and Neck Squamous Cell Carcinomas (1996) (35)
- The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities (2018) (34)
- Intracellular trafficking of CLN3, the protein underlying the childhood neurodegenerative disease, Batten disease (2003) (33)
- Genetic basis of hypoxanthine guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome (HPRTFlint). (1988) (32)
- Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy. (2015) (32)
- Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy. (1995) (31)
- Osmoregulation of ceroid neuronal lipofuscinosis type 3 in the renal medulla. (2010) (31)
- Effects of keratinocyte and hepatocyte growth factor in vivo: implications for retrovirus-mediated gene transfer to liver. (1998) (31)
- Toward RNAi Therapy for the Polyglutamine Disease Machado-Joseph Disease. (2013) (30)
- Regulated control of gene therapies by drug-induced splicing (2021) (30)
- Gene Silencing Mediated by siRNA-binding Fusion Proteins Is Attenuated by Double-stranded RNA-binding Domain Structure (2012) (30)
- Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice. (2013) (30)
- Feline immunodeficiency virus vectors. Gene transfer to mouse retina following intravitreal injection (2002) (29)
- Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo. (2015) (29)
- Replication-Deficient Adenovirus Vector Transfer ofgfpReporter Gene into Supraoptic Nucleus and Subfornical Organ Neurons (1998) (28)
- An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion (2022) (28)
- Identification of a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale) responsible for Lesch-Nyhan syndrome. (1989) (28)
- Immunolocalization and Adenoviral Vector-mediated Manganese Superoxide Dismutase Gene Transfer to Experimental Oral Tumors (2000) (28)
- Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits. (1999) (27)
- Optimization of Feline Immunodeficiency Virus Vectors for RNA Interference (2006) (26)
- Adenovirus Vector-Mediated Gene Transfer into Human Epileptogenic Brain Slices: Prospects for Gene Therapy in Epilepsy (1997) (25)
- Long‐term reversal of hypercholesterolemia in low density lipoprotein receptor (LDLR)‐deficient mice by adenovirus‐mediated LDLR gene transfer combined with CD154 blockade (2000) (25)
- Human hypoxanthine-guanine phosphoribosyltransferase: a single nucleotide substitution in cDNA clones isolated from a patient with Lesch-Nyhan syndrome (HPRTMidland). (1988) (24)
- Keratinocyte growth factor induced epithelial proliferation facilitates retroviral–mediated gene transfer to distal lung epithelia in vivo (1999) (24)
- Recent Advances in RNA Interference Therapeutics for CNS Diseases (2013) (24)
- Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma (1998) (23)
- Standard screening methods underreport AAV-mediated transduction and gene editing (2019) (23)
- Hypoxanthine-guanine phosphoribosyltransferase. Genetic evidence for identical mutations in two partially deficient subjects. (1988) (23)
- Widespread Dispersal of Cholera Toxin Subunit b to Brain and Spinal Cord Neurons Following Systemic Delivery (2002) (22)
- CLN3 Deficient Cells Display Defects in the ARF1-Cdc42 Pathway and Actin-Dependent Events (2014) (22)
- Transfection of human lactotroph adenoma cells with an adenovirus vector expressing tyrosine hydroxylase decreases prolactin release. (1996) (22)
- Adenovirus mediated gene transfer to intestinal epithelial cells as a potential approach for oral delivery of peptides and proteins (1997) (21)
- Plasmid-based RNA interference: construction of small-hairpin RNA expression vectors. (2005) (21)
- Intracellular trafficking of the JNCL protein CLN3. (1999) (21)
- The Importance of TGF-β in Murine Visceral Leishmaniasis (1998) (21)
- Adenovirus-mediated gene transfer to cultured nodose sensory neurons. (1997) (20)
- Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain (2014) (20)
- RNAi therapy for neurodegenerative diseases. (2006) (20)
- Plasmid-Based RNA Interference (2005) (20)
- Modulating membrane fluidity corrects Batten disease phenotypes in vitro and in vivo (2018) (20)
- Systemic delivery of the interleukin-1 receptor antagonist protein using a new strategy of direct adenoviral-mediated gene transfer to skeletal muscle capillary endothelium in the isolated rat hindlimb. (1996) (20)
- Human-specific microRNA regulation of FOXO1: implications for microRNA recognition element evolution. (2014) (19)
- Gene transfer to the brain using feline immunodeficiency virus-based lentivirus vectors. (2002) (19)
- Disruption of the b-Sarcoglycan Gene Reveals Pathogenetic Complexity of Limb-Girdle Muscular Dystrophy Type 2 (2000) (19)
- Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer. (1994) (18)
- Evaluating the State of the Science for Adeno-Associated Virus (AAV) Integration:An Integrated Perspective. (2022) (17)
- Gene therapy grows into young adulthood: special review issue. (2011) (17)
- A knock-in reporter mouse model for Batten disease reveals predominant expression of Cln3 in visual, limbic and subcortical motor structures (2011) (17)
- PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease (2021) (16)
- Hepatic diseases--hitting the target with inhibitory RNAs. (2003) (16)
- Rhes suppression enhances disease phenotypes in Huntington's disease mice. (2014) (16)
- Regional Variation of Splicing QTLs in Human Brain (2020) (16)
- Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain (2021) (15)
- Adeno‐Associated Virus Production, Purification, and Titering (2018) (15)
- Singles Engage the RNA Interference Pathway (2012) (14)
- A NOVEL GENE DELIVERY METHOD TRANSDUCES PORCINE PANCREATIC DUCT EPITHELIAL CELLS (2013) (14)
- Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington’s Disease (2018) (14)
- Overcoming Limitations Inherent in Sulfamidase to Improve Mucopolysaccharidosis IIIA Gene Therapy (2018) (13)
- Neuronal network dysfunction precedes storage and neurodegeneration in a lysosomal storage disorder. (2019) (13)
- Genetic expression in partial adenosine deaminase deficiency. mRNA levels and protein turnover for the enzyme variants in human B-lymphoblast cell lines. (1985) (13)
- Adenovirus Serotype 30 Fiber Does Not Mediate Transduction via the Coxsackie-Adenovirus Receptor (2002) (13)
- Tripeptide probes for tripeptidyl protease I production via gene transfer. (2003) (13)
- RNA Interference of Human α-Synuclein in Mouse (2017) (13)
- Multi‐site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats (2000) (12)
- Limited astrocyte-to-neuron conversion in the mouse brain using NeuroD1 overexpression. (2022) (12)
- Identification of a single nucleotide change in a mutant gene for hypoxanthine-guanine phosphoribosyltransferase (HPRTAnn Arbor) (1988) (12)
- Chondroitin Sulfate is the Primary Receptor for a Peptide-Modified AAV That Targets Brain Vascular Endothelium In Vivo (2014) (11)
- Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer (1996) (11)
- Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration (2015) (11)
- Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update. (2017) (11)
- Adenovirus-mediated in vivo gene transfer into the central nervous system of a nonhuman primate (resident award paper). (1994) (11)
- Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia (2012) (11)
- CRISPR to the Rescue: Advances in Gene Editing for the FMR1 Gene (2019) (10)
- Targeted gene silencing to induce permanent sterility. (2012) (10)
- Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene. (2019) (9)
- Keratinocyte growth factor induced epithelial proliferation facilitates retroviral-mediated gene transfer to distal lung epithelia in vivo. (1999) (9)
- Recombinant Adeno-Associated Viral Vector Types 4 and 5 (2003) (9)
- A recombinant adenoviral vector expressing a soluble form of VCAM-1 inhibits VCAM-1/VLA-4 adhesion in transduced synoviocytes. (1995) (9)
- Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy. (2020) (9)
- Adenoviral-Mediated Gene Transfer: Potential Therapeutic Applications (1995) (9)
- Techniques for Intracranial Stereotaxic Injections of Adeno‐Associated Viral Vectors in Adult Mice (2018) (9)
- A recombinant bCl-Xs adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells (2005) (8)
- Adenovirus-Mediated Gene Delivery to Cells of the Magnocellular Hypothalamo-neurohypophyseal System (2001) (8)
- Applying gene silencing technology to contraception. (2012) (8)
- Author Correction: Lysosomal storage diseases (2018) (7)
- All in the RNA family (2006) (7)
- Gene transfer to brain and spinal cord using recombinant adenoviral vectors. (2004) (7)
- Next-generation strategies for gene-targeted therapies of central nervous system disorders: A workshop summary (2021) (7)
- Lesch-Nyhan Syndrome due to a Single Nucleotide Change in the Hypoxanthine-Guanine Phosphoribosyltransferase Gene (HPRT Yale) (1989) (6)
- Ten steps to gene therapy for cardiovascular diseases. (1998) (5)
- Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts (2016) (5)
- Adenoviral gene transfer restores lysyl hydroxylase activity in type VI Ehlers-Danlos syndrome. (2001) (5)
- DeepRepeat: direct quantification of short tandem repeats on signal data from nanopore sequencing (2022) (5)
- Publisher Correction: Lysosomal storage diseases (2019) (5)
- Transduction of neurons lining the cerebral external capsules in mice with feline immunodeficiency virus based vectors (2003) (5)
- Lesch-Nyhan syndrome due to a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale). (1989) (4)
- Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia (2014) (4)
- Author Correction: Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes (2020) (4)
- Design and Validation of a Multi-Point Injection Technology for MR-Guided Convection Enhanced Delivery in the Brain (2021) (4)
- Doubling down on siRNAs in the brain (2019) (4)
- Recombinant adeno-associated viral vector types 4 and 5. Preparation and application for CNS gene transfer. (2003) (4)
- Neuronal genetic rescue normalizes brain network dynamics in a lysosomal storage disorder despite persistent storage accumulation (2021) (3)
- 88. Synthetic siRNAs for Huntington's Disease Therapy (2006) (3)
- The Neuronal Ceroid Lipofuscinoses: Clinical Features and Molecular Basis of Disease (2007) (3)
- A 13 base pair deletion in exon 1 of HPRTIllinois forms a functional GUG initiation codon (1994) (3)
- Taking a break from huntingtin. (2012) (3)
- Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: Molecular Basis and Clinical Relevance (1989) (3)
- Temporal Phenotypic Changes in Huntington’s Disease Models for Preclinical Studies (2022) (2)
- Extended release of recombinant adenovirus from PLGA microspheres (1996) (2)
- Pharmaceutical stabilization of adenoviral vectors (1994) (2)
- 711. Allele-Specific Silencing of Mutant Huntingtin for Huntington's Disease Therapy (2006) (2)
- CRISPR–Cas Gene Editing for Neurological Disease (2019) (2)
- 209. Gene Silencing of Human Huntingtin Using Lentivirus-Delivered shRNA (2004) (2)
- Targeted long-read sequencing captures CRISPR editing and AAV integration outcomes in brain. (2023) (2)
- 4. In Vitro and In Vivo Analysis of Feline Immunodeficiency Virus-Based Lentiviral Vector Integration|[ast]| (2004) (2)
- Continued retinal function despite NCL pathology in a Cln3 knockout mouse model of Juvenile Neuronal Ceroid Lipofuscinosis (Batten Disease) (2002) (1)
- 218. Gene Therapy and Enzyme Replacement in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis (2006) (1)
- 80. A Rapid and Effective Lentivirus Purification Procedure (2004) (1)
- 52. AAV-Delivered RNAi Improves Cellular and Motor Phenotypes in a Mouse Model for Huntington's Disease (2005) (1)
- Development expression of CLN3 in the mouse nervous system (2001) (1)
- Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases (2022) (1)
- Combined overexpression of ATXN1L and mutant ATXN1 knockdown by AAV rescue motor phenotypes and gene signatures in SCA1 mice (2022) (1)
- Cardiac mTORC 1 Dysregulation Impacts Stress Adaptation and Survival in Huntington ’ s Disease (2018) (1)
- Gene therapy grows up (and moves out of the house). (2016) (1)
- Heritable Hyperlipidemic Rabbits Adenovirus-Mediated Gene Transfer Is Augmented in Basilar and Carotid Arteries of (1998) (1)
- P 1 Caco-2 cells as an in vitro model for adenoviral gene transfer to the gut epithelium (1996) (1)
- AAV-mediated progranulin delivery to a mouse model of progranulin deficiency causes T cell-mediated hippocampal degeneration (2018) (1)
- Adenosine Deaminase Deficiency with (1983) (1)
- Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing (2022) (1)
- RETROVIRAL (RV) AND ADENOVIRAL (Ad) TRANSDUCTION OF GLIAL CELLS WITH GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF) (1997) (1)
- Amphibian ornithine aminotransferase: some general biological and chemical characteristics☆ (1982) (1)
- A TAT-modified fusion protein efficiently penetrates mouse hypoglossal nuclei from transduced ependyma (2006) (1)
- Alkyl 3-[(2,4-disubstituted-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)phenyl]propenoate derivatives. Synthesis and structure-activity relationships. (1995) (1)
- 717. RNAi Therapy for Dominant Neurodegenerative Diseases (2004) (1)
- 420. Tropism-Modified Adeno-Associated Virus Vector Mediates Targeting of Brain Vascular Endothelium In Vivo (2005) (1)
- Synthesis of normal and variant human hypoxanthine-guanine phosphoribosyltransferase in Escherichia coli. (1993) (1)
- 1059. The Lymphocytic Choriomeningitis Virus Envelope Glycoprotein Targets Lentivirus to Neural Progenitors in the Murine Brain (2004) (0)
- Abstract 20207: Deciphering and Exploiting MicroRNA-Target Interactomes in Human Cardiac Tissues (2014) (0)
- 171. Enhancing hepatocyte gene transfer with baculovirus GP64 Glycoprotein (2004) (0)
- Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4 (2011) (0)
- Selectivity and Biodistribution of WVE-120101, a Potential Antisense Oligonucleotide Therapy for the Treatment of Huntington’s Disease (S56.001) (2017) (0)
- 229. AAV4 Mediated Gene Transfer in Mucopolysaccharidosis Type VII Mice (2004) (0)
- Genetic modification of rat RPE cells using herpes and adenoviral vectors (1996) (0)
- Cell Apoptosis Ligand / Apo-2 Ligand Gene Induces Tumor TNF-Related Apoptosis-Inducing Adenoviral-Mediated Transfer of the Davidson (2000) (0)
- Abstract 18910: Deciphering and Exploiting Transcriptome-Wide MicroRNA Binding Profiles in Human Tissues (2013) (0)
- L1 CRISPR/Cas9 specific editing of the mutant huntingtin allele (2016) (0)
- Corrigendum: All in the RNA family (2006) (0)
- 27 STRUCTURAL CONSEQUENCES OF POINT MUTATIONS IN NINE HUMAN HPRT VARIANTS (1988) (0)
- RNA interference for neurodegenerative diseases (2007) (0)
- Neurobiology of Disease CHIP Suppresses Polyglutamine Aggregation and Toxicity In Vitro and In Vivo (2005) (0)
- Lysosomal Disease Network's "WORLD Symposium 2009". Introduction. (2009) (0)
- B33 Decreased heart mass and dysregulated cardiac mTORC1 activity are associated with huntington’s disease (2016) (0)
- Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics. (2021) (0)
- Small molecule therapies for juvenile neuronal ceroid lipofuscinosis (2017) (0)
- Poster 9: A New Method to Quantitate Tumor Volume in a Mouse Model of Head and Neck Squamous Cell Carcinoma Involving Secreted Human Growth Hormone by a Transduced Cell Line (1996) (0)
- Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including SYNGAP1 (2022) (0)
- Vectors Cells by Feline Immunodeficiency Virus Transduction of Dividing and Nondividing Minimum Requirements for Efficient (2013) (0)
- Lysosomal Disease Network's "WORLD Symposium 2008" (2008) (0)
- Author Correction: Regulated control of gene therapies by drug-induced splicing (2022) (0)
- NOTES Integration Site Choice of a Feline Immunodeficiency Virus Vector (2006) (0)
- Progressive Muscular Dystrophy in (cid:97) -Sarcoglycan–deficient Mice (1998) (0)
- CRISPR-related methods and compositions with conductive grna'er (2014) (0)
- 371. Optimization of Feline Immunodeficiency Viral Vectors for RNA Interference (2006) (0)
- 38. Enzyme replacement in animal models of the late infantile form of Batten disease (2009) (0)
- 816. RNAi Applications for Respiratory Epithelia: Delivery and Efficacy (2005) (0)
- Review Gene Therapy for Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases (2000) (0)
- Gene therapy matures to medicines. (2019) (0)
- 942. Adenoviral Mediated Re-Expression of Wnt Antagonist Dkk-1 Induces Apoptosis and Suppresses Tumor Growth in Medulloblastoma (2006) (0)
- 93. Targeting AAV to Brain Vascular Endothelium (2004) (0)
- Neuronal network dysfunction in juvenile neuronal lipofuscinosis (2018) (0)
- RNAi for neurological diseases (2014) (0)
- Immunosuppression Prolongs Expression of Adenoviral Vector in Mouse Anterior Segment (2005) (0)
- Structural consequences of point mutations in nine human HPRT variants. (1989) (0)
- 230. Neural Progenitor Cell Transduction with AAV Serotypes 1 and 4 (2004) (0)
- A Recombinant Adenovirus Vector Efficiently Transduces Cytotoxic Genes Into Human Head and Neck Squamous Cell Carcinoma Cell Lines (1995) (0)
- Huntington’s disease phenotypes are improved via mTORC1 modulation by small molecule therapy (2022) (0)
- Proteines a ptd modifie (2002) (0)
- lentiviral gene transfer Persistent expression of factor VIII in vivo following nonprimate (2013) (0)
- DNA Transfer to Cultured Cells (1999) (0)
- 38 LESCH-NYHAN SYNDROME DUE TO A SINGLE NUCLEOTIDE CHANGE IN THE HYPOXANTHINE-GUANIJE PHOSPHORIBOSYL-TRANSFERASE GENE (HPRTYale) (1988) (0)
- Coxsackie-Adenovirus Receptor Mediate Transduction via the Adenovirus Serotype 30 Fiber Does Not (2014) (0)
- miR-34a modulates neural progenitor cell differentiation (2008) (0)
- Eloise Hudry of Amyloid Deposition and Neurotoxicity in Mouse Brain Isoforms Results in Differential Modulation Apoe Gene Transfer of Human (2013) (0)
- 207. Micro RNAs as Novel siRNA Shuttles (2004) (0)
- The Genetic Basis of HGPRT Deficiency (1993) (0)
- Expression of normal and variant human hypoxanthine-guanine phosphoribosyltransferase in E. coli. (1991) (0)
- Therapeutic nucleic acids (2012) (0)
- DeepRepeat: direct quantification of short tandem repeats on signal data from nanopore sequencing (2022) (0)
- The limitations of central nervous systemdirected gene transfer (1995) (0)
- Exploring RNA interference as a therapeutic strategy in polyglutamine disease (2003) (0)
- 601. Persistent Expression of Factor VIII In Vivo Following FIV Lentiviral Gene Transfer (2005) (0)
- 656. Development of Viral Vectors To Mediate Neuron-Specific Gene Silencing (2005) (0)
- INFLAMMATION INDUCED BY ADENOVIRAL PARTICLES (2009) (0)
- Genes as Medicine: Molecular Therapy Comes of Age (2011) (0)
- Taking a Break From Huntingtin (2012) (0)
- Short Communications Genetic basis of hypoxanthine guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome (HPRT,,,,,) (Recombinant DNA; cDNA cloning; RNase A mapping; secondary structure prediction; hyperuricemia; gout; phage ngtll vector) (2002) (0)
- 9 Utilizing the brain microvasculature for CNS therapy (2007) (0)
- A novel delivery method to transduce genes in the pancreas (2013) (0)
- 491. Improved Apical Airway Epithelia Targeting Properties of FIV Vector Pseudotyped with Envelopes from LCMV (2004) (0)
- Efficacy of cell-type specific rescue in a new mouse model of CLN3 disease (2020) (0)
- Recent Advances in RNA Interference Therapeutics for CNS Diseases (2013) (0)
- Viral mediated transduction of murine retina with AAV2 and AAV5 (2002) (0)
- 90. miRNA Shuttles Improve Therapeutic RNAi (2006) (0)
- 427. AAV2- and AAV5-Mediated CNS Delivery of Human CLN2 Reduces Lysosomal Storage in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis (2005) (0)
- 414. Non-Allele Specific RNA Interference in the CAG140 Knock-In Mouse Model of Huntington's Disease (2006) (0)
- Identification ofa Single Nucleotide ChangeintheHypoxanthine-Guanine Phosphoribosyltransferase Gene(HPRTyaie) Responsible forLesch-Nyhan Syndrome (1989) (0)
- Abstract 17984: No Longer Silent: A Synonymous Coding SNP Modifying a Novel MicroRNA-24:SCN5A Interaction Associates With Non-Arrhythmic Death in Heart Failure (2015) (0)
- Mis-splicing in Huntington’s disease: harnessing the power of comparative transcriptomics (2021) (0)
- Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts. (2016) (0)
- 133. Lack of CLN3 results in altered physiology of mouse brain endothelial cells (2010) (0)
- Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes (2018) (0)
- 35. Disease brain endothelia provide unique molecular signatures for CNS-directed enzyme therapy (2010) (0)
- Regulated control of gene therapies with a drug induced switch (2020) (0)
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What Schools Are Affiliated With Beverly L. Davidson?
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