Bharat Aggarwal

Q: What Schools Are Affiliated With Bharat Aggarwal

Bharat Aggarwal is affiliated with the following schools: Australian National University, Delhi University, University of California, Berkeley, MD Anderson Cancer Center, Banaras Hindu University, University of Washington

Bharat Aggarwal's AcademicInfluence.com Rankings

Bharat Aggarwal

Biology

#717

World Rank

#1250

Historical Rank

Biochemistry

#68

World Rank

#88

Historical Rank

biology Degrees

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Biology

Bharat Aggarwal's Degrees

PhD Biochemistry University of California, Berkeley
Masters Biochemistry University of California, Berkeley
Bachelors Chemistry Delhi University

Why Is Bharat Aggarwal Influential?

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According to Wikipedia, Bharat B. Aggarwal is an Indian-American biochemist. His research has been in the areas of cytokines, the role of inflammation in cancer, and the anti-cancer effects of spices and herbs, particularly curcumin . He was a professor in the Department of Clinical Immunology, Bioimmunotherapy, and Experimental Therapeutics at University of Texas MD Anderson Cancer Center in Houston, Texas.

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Bharat Aggarwal's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Bioavailability of curcumin: problems and promises. (2007) (4258)
Oxidative stress, inflammation, and cancer: how are they linked? (2010) (4064)
Signalling pathways of the TNF superfamily: a double-edged sword (2003) (2626)
Anticancer potential of curcumin: preclinical and clinical studies. (2003) (2557)
Curcumin as "Curecumin": from kitchen to clinic. (2008) (1940)
Molecular targets of dietary agents for prevention and therapy of cancer. (2006) (1721)
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin (1984) (1701)
Cancer is a Preventable Disease that Requires Major Lifestyle Changes (2008) (1697)
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. (2009) (1580)
Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. (1985) (1576)
Curcumin: the Indian solid gold. (2007) (1544)
Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials (2012) (1409)
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. (2004) (1388)
Inflammation and cancer: how hot is the link? (2006) (1314)
Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane) (*) (1995) (1264)
Nuclear factor-kappaB: the enemy within. (2004) (1229)
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer (2008) (1144)
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. (1996) (1102)
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. (2008) (1072)
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. (2008) (1016)
Curcumin and cancer: an "old-age" disease with an "age-old" solution. (2008) (1008)
Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. (2009) (965)
Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation1 (2000) (881)
Human tumor necrosis factor. Production, purification, and characterization. (1985) (877)
Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon (1985) (862)
Nuclear factor-κB: its role in health and disease (2004) (848)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. (1985) (804)
Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice (2014) (802)
Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals (2010) (711)
Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively? (2009) (705)
Discovery of curcumin, a component of golden spice, and its miraculous biological activities (2012) (693)
Curcumin: Getting Back to the Roots (2005) (683)
Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe (2009) (680)
Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey. (2012) (678)
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis (2003) (671)
Inhibiting NF-κB activation by small molecules as a therapeutic strategy. (2010) (668)
Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer (2009) (634)
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases (2017) (627)
Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. (2012) (608)
Curcumin, a component of golden spice: from bedside to bench and back. (2014) (603)
Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1* (1998) (601)
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. (2007) (588)
Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. (2010) (578)
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. (2007) (576)
Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice (2005) (572)
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity (1984) (570)
Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. (2003) (559)
Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation (2006) (548)
Role of chemopreventive agents in cancer therapy. (2004) (541)
Multitargeting by curcumin as revealed by molecular interaction studies. (2011) (538)
“Spicing Up” of the Immune System by Curcumin (2007) (531)
Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. (1995) (525)
Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. (2010) (511)
Tumor necrosis factors: developments during the last decade. (1996) (508)
Nuclear factor-kappa B and cancer: its role in prevention and therapy. (2002) (502)
Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells 1 (2003) (501)
Resveratrol: A multitargeted agent for age-associated chronic diseases (2008) (501)
Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. (2006) (500)
Evidence That Curcumin Suppresses the Growth of Malignant Gliomas in Vitro and in Vivo through Induction of Autophagy: Role of Akt and Extracellular Signal-Regulated Kinase Signaling Pathways (2007) (499)
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. (2005) (476)
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. (2002) (452)
Curcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs (2010) (451)
Cancer is a Preventable Disease that Requires Major Lifestyle Changes (2008) (438)
Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines (2001) (432)
Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. (2002) (429)
TNF: a master switch for inflammation to cancer. (2008) (417)
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. (2010) (417)
NF-κB addiction and its role in cancer: ‘one size does not fit all’ (2011) (415)
TNF-Induced Signaling in Apoptosis (1999) (414)
Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer (2006) (413)
The molecular targets and therapeutic uses of curcumin in health and disease (2007) (413)
Hydrogen Peroxide Activates NF-κB through Tyrosine Phosphorylation of IκBα and Serine Phosphorylation of p65 (2003) (409)
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. (1999) (408)
Nuclear factor-kappaB: its role in health and disease. (2004) (406)
Role of curcumin in cancer therapy. (2007) (403)
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. (1998) (402)
Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives (2005) (397)
Ursolic Acid Inhibits Nuclear Factor-κB Activation Induced by Carcinogenic Agents through Suppression of IκBα Kinase and p65 Phosphorylation: Correlation with Down-Regulation of Cyclooxygenase 2, Matrix Metalloproteinase 9, and Cyclin D1 (2003) (396)
Transcription Factor NF‐κB: A Sensor for Smoke and Stress Signals (2005) (395)
Curcumin Inhibits Tumor Growth and Angiogenesis in Ovarian Carcinoma by Targeting the Nuclear Factor-κB Pathway (2007) (387)
Inflammation and cancer: how friendly is the relationship for cancer patients? (2009) (385)
Human interleukin 1 is a cytocidal factor for several tumor cell lines. (1985) (384)
Suppression of the Nuclear Factor‐κB Activation Pathway by Spice‐Derived Phytochemicals: Reasoning for Seasoning (2004) (380)
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. (2007) (379)
Natural products as a gold mine for arthritis treatment. (2007) (378)
Nuclear Factor-κB Activation: From Bench to Bedside (2008) (369)
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation (2002) (363)
Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach. (2011) (359)
NF-κB and cancer: how intimate is this relationship (2010) (351)
Identification and Characterization of a Novel Cytokine, THANK, aTNF Homologue That ActivatesApoptosis, Nuclear Factor-κB, and c-Jun NH2-Terminal Kinase* (1999) (345)
Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. (1997) (343)
A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer (2011) (339)
Curcumin, a component of turmeric: From farm to pharmacy (2013) (334)
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. (2004) (331)
Multitargeting by turmeric, the golden spice: From kitchen to clinic. (2013) (330)
Chemical Composition and Product Quality Control of Turmeric (Curcuma longa L.) (2011) (326)
Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates. (1998) (322)
Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. (2008) (319)
Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. (2003) (311)
Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways (2008) (311)
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. (2003) (308)
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. (2007) (308)
Resveratrol addiction: to die or not to die. (2009) (306)
Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers (2013) (302)
Cancer drug discovery by repurposing: teaching new tricks to old dogs. (2013) (302)
Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis (2008) (297)
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). (2007) (296)
Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-κB Activation and NF-κB-regulated Gene Products Through Modulation of p65 and IκBα Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents* (2006) (293)
Anticancer potential of silymarin: from bench to bed side. (2006) (293)
Silymarin Suppresses TNF-Induced Activation of NF-κB, c-Jun N-Terminal Kinase, and Apoptosis (1999) (286)
Epigenetic changes induced by curcumin and other natural compounds (2011) (286)
The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. (2011) (282)
Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor (1998) (280)
Potential of spice-derived phytochemicals for cancer prevention. (2008) (276)
Turmeric, the golden spice: From traditional medicine to modern medicine (2011) (274)
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-κB activation through inhibition of IκBα kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1 (2003) (273)
Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward (2006) (272)
Cancer prevention with natural compounds. (2010) (270)
Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. (1986) (269)
Chemosensitization of tumors by resveratrol (2011) (268)
From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer (2006) (267)
Chemosensitization and radiosensitization of tumors by plant polyphenols. (2005) (267)
Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation* (1997) (266)
Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization. (1984) (261)
Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer (2010) (259)
γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis* (2007) (257)
Cigarette smoke condensate activates nuclear transcription factor-κB through phosphorylation and degradation of IκBα: correlation with induction of cyclooxygenase-2 (2002) (257)
Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. (2014) (257)
Nuclear factor‐κB and IκB kinase are constitutively active in human pancreatic cells, and their down‐regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis (2004) (253)
From kitchen to clinic (2007) (253)
Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein. (1987) (248)
Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation. (1998) (248)
Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials. (2016) (247)
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor‐κB signaling (2004) (246)
Reactive oxygen intermediates in TNF signaling. (2002) (241)
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalp (2008) (240)
α-Melanocyte-Stimulating Hormone Inhibits the Nuclear Transcription Factor NF-κB Activation Induced by Various Inflammatory Agents (1998) (238)
Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells (2007) (238)
Nuclear factor-kappaB activation: from bench to bedside. (2008) (237)
Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-κB (2000) (237)
Inhibition of Tumor Necrosis Factor (TNF-α)-mediated Apoptosis by Hepatitis C Virus Core Protein* (1998) (236)
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. (1999) (235)
Imatinib Mesylate Resistance Through BCR-ABL Independence in Chronic Myelogenous Leukemia (2004) (235)
RKIP Sensitizes Prostate and Breast Cancer Cells to Drug-induced Apoptosis* (2004) (234)
Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy (2009) (230)
Nuclear Factor-κB Activation: A Question of Life or Death (2002) (230)
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. (2007) (227)
Nuclear factor-κB: a friend or a foe in cancer? (2004) (227)
Curcumin is a non‐competitive and selective inhibitor of phosphorylase kinase (1994) (227)
Curcumin and liver cancer: a review. (2012) (226)
Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-κB Ligand-Induced NF-κB Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis1 (2004) (225)
The p60 Tumor Necrosis Factor (TNF) Receptor-associated Kinase (TRAK) Binds Residues 344–397 within the Cytoplasmic Domain Involved in TNF Signaling (*) (1995) (225)
Transcription factor NF-kappaB: a sensor for smoke and stress signals. (2005) (224)
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. (2010) (223)
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation (2004) (223)
Curcumin‐induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor κB activity and are independent of the B‐Raf/mitogen‐activated/extracellular signal‐regulated protein kinase pathway and the Akt pathway (2005) (222)
Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. (2013) (221)
Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. (2008) (220)
Probiotic Lactobacillus reuteri promotes TNF‐induced apoptosis in human myeloid leukemia‐derived cells by modulation of NF‐κB and MAPK signalling (2008) (219)
Guggulsterone Inhibits NF-κB and IκBα Kinase Activation, Suppresses Expression of Anti-apoptotic Gene Products, and Enhances Apoptosis* (2004) (217)
Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT (2012) (217)
Age-associated chronic diseases require age-old medicine: role of chronic inflammation. (2012) (215)
Multi-targeted therapy by curcumin: how spicy is it? (2008) (213)
Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation1 (2002) (213)
Characterization of the antitumor activities of human tumor necrosis factor-alpha and the comparison with other cytokines: induction of tumor-specific immunity. (1987) (213)
α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells (1992) (213)
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway. (2006) (212)
Receptor Binding and Activation of Polymorphonuclear Neutrophils by Tumor Necrosis Factor‐Alpha (1987) (211)
Nuclear transcription factor-kappaB as a target for cancer drug development. (2002) (207)
A Previously Unrecognized Protein-Protein Interaction between TWEAK and CD163: Potential Biological Implications1 (2007) (206)
Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. (2003) (206)
Early events in TNF signaling: a story of associations and dissociations (1997) (204)
Curcumin mediates anticancer effects by modulating multiple cell signaling pathways. (2017) (204)
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. (2010) (204)
Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-κB, AP-1, JNK, MAPKK and apoptosis (2000) (203)
Tumor necrosis factors: gene structure and biological activities. (1986) (202)
Betulinic Acid Suppresses Carcinogen-Induced NF-κB Activation Through Inhibition of IκBα Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and Matrix Metalloprotease-9 (2003) (202)
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer (2010) (202)
Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-κB activation and proliferation in human head and neck squamous cell carcinoma (2007) (201)
Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to γ-Radiation by Targeting Nuclear Factor-κB–Regulated Gene Products (2008) (201)
Leflunomide Suppresses TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Protein Kinase, and Apoptosis1 (2000) (199)
Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. (2009) (198)
Chronic diseases, inflammation, and spices: how are they linked? (2018) (198)
Mechanisms for Lysophosphatidic Acid-induced Cytokine Production in Ovarian Cancer Cells* (2004) (197)
Assay for redox-sensitive transcription factor. (2000) (194)
Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. (2010) (193)
From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. (2007) (193)
Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6–Inducible STAT3 Activation (2007) (192)
Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor-κB-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products through the Suppression of TAK-1 and Receptor-Interacting Protein-Regulated IκBα Kinase Activation (2007) (188)
TNF induces internalization of the p60 receptor and shedding of the p80 receptor. (1994) (188)
Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses (2014) (185)
Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase. (2000) (185)
TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption (1998) (183)
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX‐2, MMP‐9, VEGF and CXCR4 expression in an orthotopic mouse model (2009) (183)
Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis (2009) (180)
Identification of a p65 Peptide That Selectively Inhibits NF-κ B Activation Induced by Various Inflammatory Stimuli and Its Role in Down-regulation of NF-κB-mediated Gene Expression and Up-regulation of Apoptosis* (2004) (180)
From chemoprevention to chemotherapy: common targets and common goals (2004) (180)
Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention (2016) (178)
Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation1 (2001) (177)
Acetyl-11-Keto-β-Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-κB and NF-κB-Regulated Gene Expression1 (2006) (177)
Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation. (1998) (176)
Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. (2003) (176)
Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals (2012) (175)
Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. (2009) (175)
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression (2006) (175)
Thalidomide Suppresses NF-κB Activation Induced by TNF and H2O2, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester1 (2002) (174)
Genetic Deletion of Glycogen Synthase Kinase-3β Abrogates Activation of IκBα Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor* (2004) (172)
Nuclear factor‐κB (nf‐κB) is frequently expressed in lung cancer and preneoplastic lesions (2006) (172)
The synergistic anti-proliferative effect of gamma-interferon and human lymphotoxin. (1984) (171)
Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin (1984) (171)
Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue* (2007) (171)
Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. (2009) (170)
Necrosis and Glioblastoma: A Friend or a Foe? A Review and a Hypothesis (2002) (169)
VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo (1999) (169)
Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis1 (2004) (167)
Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-κB activation, IκB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells (1998) (167)
Zerumbone abolishes NF-κB and IκBα kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion (2005) (166)
Curcumin Derived from Turmeric ( Curcuma longa ): a Spice for All Seasons (2005) (165)
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. (2008) (161)
Receptor-Mediated Choreography of Life and Death (2003) (160)
Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. (2008) (160)
Nuclear factor-κ B : The enemy within (2004) (160)
Primary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line. (1985) (159)
Flavopiridol Inhibits NF-κB Activation Induced by Various Carcinogens and Inflammatory Agents through Inhibition of IκBα Kinase and p65 Phosphorylation (2004) (159)
Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors (1998) (156)
Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. (2010) (156)
Overexpression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1 (1999) (155)
Nuclear factor-κB (2004) (154)
Evodiamine Abolishes Constitutive and Inducible NF-κB Activation by Inhibiting IκBα Kinase Activation, Thereby Suppressing NF-κB-regulated Antiapoptotic and Metastatic Gene Expression, Up-regulating Apoptosis, and Inhibiting Invasion* (2005) (154)
Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor-κB (NF-κB) Signaling Pathway Leading to Suppression of NF-κB-Regulated Antiapoptotic and Metastatic Gene Products (2007) (153)
Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. (2007) (153)
Models for prevention and treatment of cancer: problems vs promises. (2009) (152)
Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. (2003) (151)
Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function. (1997) (150)
Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells. (1997) (148)
Apoptosis and nuclear factor-κb: a tale of association and dissociation (2000) (148)
Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis. (2017) (148)
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents. (1996) (147)
Association of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinoma. (2006) (146)
Photo-oxidative Stress Down-modulates the Activity of Nuclear Factor-κB via Involvement of Caspase-1, Leading to Apoptosis of Photoreceptor Cells* (1999) (145)
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model (2009) (145)
In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria (1992) (144)
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-κB and nuclear factor-κB–regulated gene products in IFN-α–sensitive and IFN-α–resistant human bladder cancer cells (2007) (144)
Role of nuclear factor-κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents (2011) (144)
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. (2009) (144)
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. (2001) (142)
Targeting cell signaling pathways for drug discovery: An old lock needs a new key (2007) (141)
Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. (2004) (138)
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential. (2010) (137)
Nuclear factor-kappaB activation: a question of life or death. (2002) (137)
Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor (1995) (137)
A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo (2010) (136)
The role of TNF and its family members in inflammation and cancer: lessons from gene deletion. (2002) (136)
A Synthetic Triterpenoid, CDDO-Me, Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor κB–Regulated Gene Products in Human Leukemic Cells (2006) (135)
Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells. (1988) (135)
Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes. (1986) (132)
Back to basics: how natural products can provide the basis for new therapeutics (2007) (132)
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. (2008) (131)
Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine (2012) (131)
Neuroprotection by Spice-Derived Nutraceuticals: You Are What You Eat! (2011) (131)
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. (2004) (130)
Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor-κB Activation Pathway (2006) (130)
Tumor necrosis factors. Structure, function, and mechanism of action. (1992) (129)
Indole-3-carbinol suppresses NF-κB and IκBα kinase activation, causing inhibition of expression of NF-κB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells (2005) (129)
Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. (2008) (129)
Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. (1999) (128)
{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. (2010) (128)
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases (2018) (127)
Nuclear transcription factor NF-kappa B: role in biology and medicine. (2004) (127)
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response. (1994) (127)
Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. (2011) (127)
Inhibition by all‐trans‐retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages (1994) (126)
HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1. (1998) (125)
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. (2007) (125)
Is curcumin bioavailability a problem in humans: lessons from clinical trials (2019) (123)
Expression of NF‐κB parallels COX‐2 expression in oral precancer and cancer: Association with smokeless tobacco (2007) (123)
Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1 (2009) (123)
Tocotrienols fight cancer by targeting multiple cell signaling pathways (2011) (122)
Pinitol targets nuclear factor-κB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis (2008) (122)
Protein Farnesyltransferase Inhibitor (SCH 66336) Abolishes NF-κB Activation Induced by Various Carcinogens and Inflammatory Stimuli Leading to Suppression of NF-κB-regulated Gene Expression and Up-regulation of Apoptosis* (2004) (122)
Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. (2004) (121)
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. (2007) (121)
Exogenous Nef Protein Activates NF-κB, AP-1, and c-Jun N-Terminal Kinase and Stimulates HIV Transcription in Promonocytic Cells (2003) (121)
Celastrol, a Triterpene, Enhances TRAIL-induced Apoptosis through the Down-regulation of Cell Survival Proteins and Up-regulation of Death Receptors* (2010) (121)
Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. (2004) (121)
TNF blockade: an inflammatory issue. (2006) (121)
Site-specific Tyrosine Phosphorylation of IκBα Negatively Regulates Its Inducible Phosphorylation and Degradation* (1996) (120)
NF-κB in cancer: a matter of life and death. (2011) (120)
Targeting constitutive and interleukin‐6‐inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane) (2006) (119)
10 Curcumin — Biological and Medicinal Properties (2006) (119)
Nuclear factor-kappa B: from clone to clinic. (2007) (119)
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. (2002) (119)
Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-B (*) (1995) (119)
TNF Activates Syk Protein Tyrosine Kinase Leading to TNF-Induced MAPK Activation, NF-κB Activation, and Apoptosis1 (2004) (118)
Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1 (2009) (118)
Morin (3,5,7,2′,4′-Pentahydroxyflavone) Abolishes Nuclear Factor-κB Activation Induced by Various Carcinogens and Inflammatory Stimuli, Leading to Suppression of Nuclear Factor-κB–Regulated Gene Expression and Up-regulation of Apoptosis (2007) (118)
Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression (2006) (118)
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. (2004) (118)
Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors (2004) (117)
The guggul for chronic diseases: ancient medicine, modern targets. (2008) (115)
Biological and binding activities of equine pituitary gonadotrophins and pregnant mare serum gonadotrophin. (1979) (115)
Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. (2012) (113)
Therapeutic Significance of Elevated Tissue Transglutaminase Expression in Pancreatic Cancer (2008) (113)
Evidence That Receptor Activator of Nuclear Factor (NF)-κB Ligand Can Suppress Cell Proliferation and Induce Apoptosis through Activation of a NF-κB-independent and TRAF6-dependent Mechanism* (2004) (112)
Suberoylanilide Hydroxamic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing Nuclear Factor-κB Activation* (2006) (111)
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. (2006) (111)
Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL* (2010) (110)
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. (2008) (110)
Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells. (2006) (109)
Molecular Targets and Therapeutic Uses of Spices: Modern Uses for Ancient Medicine (2009) (108)
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. (2004) (107)
Chemopreventive Agents Induce Suppression of Nuclear Factor‐κB Leading to Chemosensitization (2002) (107)
Chemopreventive and chemotherapeutic potential of curcumin in breast cancer. (2012) (107)
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. (2006) (107)
Deguelin, an Akt Inhibitor, Suppresses IκBα Kinase Activation Leading to Suppression of NF-κB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion1 (2006) (107)
Indirubin Enhances Tumor Necrosis Factor-induced Apoptosis through Modulation of Nuclear Factor-κB Signaling Pathway* (2006) (107)
Targeting TNF for Treatment of Cancer and Autoimmunity. (2009) (107)
Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation. (1994) (107)
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. (2009) (106)
Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line. (2010) (105)
Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through an NFκB-dependent Pathway* (2006) (104)
Simvastatin, 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor‐κB ligand through modulation of NF‐κB pathway (2008) (104)
HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line. (1990) (104)
Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling. (2010) (103)
Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents. (1998) (102)
Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. (2005) (102)
Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes. (1989) (102)
Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products (2010) (102)
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP‐1 in human multiple myeloma cells (2010) (101)
IFN-α Suppresses Activation of Nuclear Transcription Factors NF-κB and Activator Protein 1 and Potentiates TNF-Induced Apoptosis1 (2000) (101)
Adenosine suppresses activation of nuclear factor-κB selectively induced by tumor necrosis factor in different cell types (2003) (100)
Aeromonas hydrophila Cytotoxic Enterotoxin Activates Mitogen-activated Protein Kinases and Induces Apoptosis in Murine Macrophages and Human Intestinal Epithelial Cells* (2004) (100)
Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. (2004) (99)
Resveratrol in health and disease (2005) (99)
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. (2002) (99)
Genetic Deletion of NAD(P)H:Quinone Oxidoreductase 1 Abrogates Activation of Nuclear Factor-κB, IκBα Kinase, c-Jun N-terminal Kinase, Akt, p38, and p44/42 Mitogen-activated Protein Kinases and Potentiates Apoptosis* (2006) (99)
Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates. (1999) (98)
Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells. (1996) (98)
The Nuclear Transcription Factor κB/bcl-2 Pathway Correlates with Pathologic Complete Response to Doxorubicin-Based Neoadjuvant Chemotherapy in Human Breast Cancer (2005) (97)
Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family. (2012) (97)
Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-11 (2007) (97)
Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα (2007) (97)
Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers (2012) (97)
Cancer-linked targets modulated by curcumin. (2012) (95)
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. (2009) (94)
Aldose Reductase Mediates Mitogenic Signaling in Vascular Smooth Muscle Cells* (2002) (93)
Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation‐mediated molecular events related to multistep carcinogenesis (2011) (93)
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. (2007) (92)
Effects of growth factors on the antiproliferative activity of tumor necrosis factors. (1987) (92)
Human Cytokines: Handbook for Basic and Clinical Research (1996) (92)
Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro. (2010) (92)
Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. (2004) (90)
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions. (2006) (89)
Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents* (2010) (89)
Human tumor necrosis factor. (1985) (89)
Genetic deletion of PKR abrogates TNF-induced activation of IκBα kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation (2007) (88)
Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax* (2010) (88)
Cutting Edge: TRANK, a Novel Cytokine That Activates NF-κB and c-Jun N-Terminal Kinase (1998) (88)
Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-α Antagonist* (2008) (88)
Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. (2004) (87)
A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. (2006) (87)
Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-κB, degradation of IκBα, nuclear translocation of p65, and subsequent gene expression (1998) (87)
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. (2001) (86)
Characterization of human tumor necrosis factor produced by peripheral blood monocytes and its separation from lymphotoxin (1985) (86)
Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice. (2009) (86)
Identification of a Novel Blocker of IκBα Kinase That Enhances Cellular Apoptosis and Inhibits Cellular Invasion through Suppression of NF-κB-Regulated Gene Products1 (2005) (86)
Lymphotoxin is an autocrine growth factor for Epstein-Barr virus- infected B cell lines (1993) (85)
Erratum: Activation of transcription factor NF-κb is suppressed by curcumin (diferuloylmethane) (Journal of Biological Chemistry (1995) 270 (24995-25000)) (1995) (85)
Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor (2010) (84)
Damage to mitochondrial electron transport and energy coupling by visible light. (1978) (84)
Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells. (1999) (84)
Redox regulation of apoptosis by members of the TNF superfamily. (2005) (83)
Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. (2007) (83)
Tumor necrosis factors α and β differ in their capacities to generate interleukin 1 release from human endothelial cells (1987) (83)
Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases (2016) (82)
Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins (2010) (82)
Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. (2006) (82)
5-Hydroxy-2-Methyl-1,4-Naphthoquinone, a Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization (2010) (81)
Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthotopic Nude Mouse Model through Modulation of Multiple Targets (2011) (81)
Prostate cancer and curcumin: Add spice to your life (2008) (81)
Guggulsterone Inhibits Osteoclastogenesis Induced by Receptor Activator of Nuclear Factor-κB Ligand and by Tumor Cells by Suppressing Nuclear Factor-κB Activation (2006) (81)
Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. (2004) (81)
Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors (1999) (80)
ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins. (2011) (79)
Interleukin-4 Down-regulates Both Forms of Tumor Necrosis Factor Receptor and Receptor-mediated Apoptosis, NF-κB, AP-1, and c-Jun N-Terminal Kinase (1998) (79)
Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. (2005) (78)
Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors. (2004) (78)
Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. (2010) (78)
Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia. (2004) (78)
Nuclear factor-kappaB: a friend or a foe in cancer? (2004) (78)
Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors (2010) (78)
Lead activates nuclear transcription factor-kappaB, activator protein-1, and amino-terminal c-Jun kinase in pheochromocytoma cells. (1999) (78)
Synthetic Vpr Protein Activates Activator Protein-1, c-Jun N-terminal Kinase, and NF-κB and Stimulates HIV-1 Transcription in Promonocytic Cells and Primary Macrophages* (2005) (77)
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. (2003) (77)
IL-13 suppresses TNF-induced activation of nuclear factor-kappa B, activation protein-1, and apoptosis. (1998) (77)
Induction of Matrix Metalloproteinase-9 Requires a Polymerized Actin Cytoskeleton in Human Malignant Glioma Cells* (1998) (76)
Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation. (1996) (76)
Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. (2012) (74)
Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells (2005) (74)
Resveratrol Chemosensitizes TNF-β-Induced Survival of 5-FU-Treated Colorectal Cancer Cells (2018) (74)
Ovarian actions of tumor necrosis factor-α (TNFα): Pleiotropic effects of TNFα on differentiated functions of untransformed swine granulosa cells (1991) (74)
γ-Tocotrienol Promotes TRAIL-Induced Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase/p53–Mediated Upregulation of Death Receptors (2010) (74)
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis. (2006) (74)
VEGI, a new member of the TNF family activates Nuclear Factor-κB and c-Jun N-terminal kinase and modulates cell growth (1999) (74)
Novel curcumin analogs targeting TNF-induced NF-kappaB activation and proliferation in human leukemic KBM-5 cells. (2006) (73)
Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment (2013) (73)
Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor‐kappa‐B, cyclooxygenase and tumor cell proliferation (2009) (73)
Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression. (2006) (73)
K-Ras Promotes Angiogenesis Mediated by Immortalized Human Pancreatic Epithelial Cells through Mitogen-Activated Protein Kinase Signaling Pathways (2009) (73)
Induction of receptors for tumor necrosis factor-alpha by interferons is not a major mechanism for their synergistic cytotoxic response. (1987) (72)
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. (2007) (72)
Anticancer drugs designed by mother nature: ancient drugs but modern targets. (2007) (72)
Human Chorionic Gonadotropin Decreases Proliferation and Invasion of Breast Cancer MCF-7 Cells by Inhibiting NF-κB and AP-1 Activation* (2004) (72)
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. (2007) (71)
Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway. (2010) (70)
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-κB pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis (2008) (70)
Pervanadate-induced Nuclear Factor-κB Activation Requires Tyrosine Phosphorylation and Degradation of IκBα (2000) (70)
Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor-alpha. (1987) (69)
Experimental Biology and Medicine (2007) (69)
Inflammation, NF-κB, and Chronic Diseases: How are They Linked? (2020) (69)
Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells. (1992) (68)
Interferon‐γ induces cell surface expression for both types of tumor necrosis factor receptors (1992) (68)
Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. (2007) (68)
Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK) (1998) (67)
Genetic Deletion of the Tumor Necrosis Factor Receptor p60 or p80 Abrogates Ligand-mediated Activation of Nuclear Factor-κB and of Mitogen-activated Protein Kinases in Macrophages* (2001) (67)
Enzyme levels of normal human cells: aging in culture. (1975) (66)
Wortmannin inhibits activation of nuclear transcription factors NF‐κB and activated protein‐1 induced by lipopolysaccharide and phorbol ester (2000) (66)
Prevention and Treatment of Colorectal Cancer by Natural Agents from Mother Nature (2013) (65)
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha. (2007) (65)
Human tumor necrosis factor-alpha receptor. Purification by immunoaffinity chromatography and initial characterization. (1988) (65)
Cytokines: from clone to clinic. (1992) (65)
γ-Tocotrienol but Not γ-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic Agents* (2010) (65)
Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of Nuclear Factor-κB Signaling Pathway (2010) (65)
Cardamonin sensitizes tumour cells to TRAIL through ROS‐ and CHOP‐mediated up‐regulation of death receptors and down‐regulation of survival proteins (2012) (64)
Differential Requirement for p56lck in HIV-tat Versus TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Kinase, and Apoptosis1 (2000) (64)
Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: Role of the nuclear transcription factor NF‐xB (1997) (64)
Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis. (1999) (64)
Modulation of the Growth of Transformed Cells by Human Tumor Necrosis Factor-α and Interferon-γ (1987) (64)
Acetyl‐11‐keto‐β‐boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression (2011) (64)
Inhibitory Effects of Black Pepper (Piper Nigrum) Extracts and Compounds on Human Tumor Cell Proliferation, Cyclooxygenase Enzymes, Lipid Peroxidation and Nuclear Transcription Factor-kappa-B (2010) (63)
Bcl-2 overexpression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-kappaB preservation. (2001) (63)
Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. (1997) (63)
Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases (2018) (62)
Curcumin glucuronides: assessing the proliferative activity against human cell lines. (2014) (62)
Curcumin hormesis mediates a cross-talk between autophagy and cell death (2015) (62)
Nuclear Factor-κB: A Holy Grail in Cancer Prevention and Therapy (2006) (62)
Protein Tyrosine Kinase p56 lck Is Required for Ceramide-induced but Not Tumor Necrosis Factor-induced Activation of NF-κB, AP-1, JNK, and Apoptosis* (2000) (62)
Characterization of the in vitro and in vivo species preference of human and murine tumor necrosis factor-alpha. (1988) (61)
Human immunodeficiency virus type 1 tat gene up-regulates interleukin 4 receptors on a human B-lymphoblastoid cell line. (1992) (61)
Pretherapy nuclear factor-κB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma (2006) (61)
Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation. (1995) (61)
All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-κB, activated protein-1 and apoptosis in human lung cancer cells (2000) (60)
Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment. (2014) (60)
Death domain receptors and their role in cell demise. (1998) (60)
Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. (2005) (59)
Curcumin improves the therapeutic efficacy of Listeriaat-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1 (2013) (59)
Plumbagin Inhibits Osteoclastogenesis and Reduces Human Breast Cancer-Induced Osteolytic Bone Metastasis in Mice through Suppression of RANKL Signaling (2011) (58)
Cancer and diet: How are they related? (2011) (58)
Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin (2015) (58)
Curcumin Downregulates NF-kB and Related Genes in Patients with Multiple Myeloma: Results of a Phase I/II Study. (2007) (58)
Monoclonal antibodies to human tumor necrosis factors alpha and beta: application for affinity purification, immunoassays, and as structural probes. (1987) (58)
Isodeoxyelephantopin, a Novel Sesquiterpene Lactone, Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis through Suppression of Nuclear Factor-κB (NF-κB) Activation and NF-κB-Regulated Gene Expression (2006) (57)
Human immunodeficiency virus‐1‐tat induces matrix metalloproteinase‐9 in monocytes through protein tyrosine phosphatase‐mediated activation of nuclear transcription factor NF‐κB (1999) (57)
Apoptosis and nuclear factor-kappa B: a tale of association and dissociation. (2000) (57)
Cancer drug development: The missing links (2019) (56)
Effect of Low-Fat Diets on Plasma Levels of NF-κB–Regulated Inflammatory Cytokines and Angiogenic Factors in Men with Prostate Cancer (2011) (56)
Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide. (1994) (56)
Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment (2016) (55)
Effect of tumour necrosis factor‐α (TNF‐α) and interferon‐γ (IFN‐γ) on human sperm motility, viability and motion parameters (1997) (55)
Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60. (2002) (55)
Suppression of tumor necrosis factor-activated nuclear transcription factor-κB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β-lapachone (1999) (55)
Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1. (2013) (54)
Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation. (1995) (54)
Targeting death receptors for TRAIL by agents designed by Mother Nature. (2014) (54)
Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation (2014) (53)
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. (2006) (53)
Down-regulation of Integrin αvβ3 Expression and Integrin-mediated Signaling in Glioma Cells by Adenovirus-mediated Transfer of Antisense Urokinase-type Plasminogen Activator Receptor (uPAR) and Sense p16 Genes* (2001) (53)
Butanol fraction containing berberine or related compound from nexrutine® inhibits NFκB signaling and induces apoptosis in prostate cancer cells (2009) (53)
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells (2012) (52)
Protein kinase D1 promotes anchorage‐independent growth, invasion, and angiogenesis by human pancreatic cancer cells (2011) (52)
Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. (2014) (52)
Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. (2007) (52)
Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism (2013) (51)
Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis. (2008) (51)
Inflammation, a silent killer in cancer is not so silent! (2009) (51)
Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG. (1997) (50)
Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain. (2001) (50)
Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. (1994) (49)
γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer. (2011) (49)
A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NFκB motif drives the transition from a repressed to an activated state of gene expression (2004) (48)
Induction of the Epithelial-to-Mesenchymal Transition of Human Colorectal Cancer by Human TNF-β (Lymphotoxin) and its Reversal by Resveratrol (2019) (47)
Gambogic Acid Inhibits STAT3 Phosphorylation through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis (2011) (47)
Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors. EVIDENCE FOR THE ROLE OF REACTIVE OXYGEN SPECIES AND JNK. (2016) (47)
Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line. (1995) (47)
TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase. (1998) (47)
Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication. (2011) (46)
Ranking the role of RANK ligand in apoptosis (2004) (46)
Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets (2012) (46)
Increased lymphotoxin in human malarial serum, and the ability of this cytokine to increase plasma interleukin-6 and cause hypoglycaemia in mice: implications for malarial pathology. (1992) (46)
Dietary natural products and their potential to influence health and disease including animal model studies (2018) (46)
N-(4-Hydroxyphenyl)Retinamide Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis through Down-regulation of IκBα Kinase and Nuclear Factor-κB–Regulated Gene Products (2005) (45)
Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment. (2017) (45)
Curcumin (Diferuloylmethane) Downregulates the Constitutive Activation of Nuclear Factor κB and IκBα Kinase in Human Multiple Myeloma Cells Leading to Suppression of Proliferation and Induction of Apoptosis (2002) (44)
Serendipity in Cancer Drug Discovery: Rational or Coincidence? (2016) (44)
Pro-apototic and anti-apoptotic effects of tumor necrosis factor in tumor cells. Role of nuclear transcription factor NF-kappaB. (2005) (44)
IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis. (2000) (44)
COVID-19, cytokines, inflammation, and spices: How are they related? (2021) (43)
Piperlongumine Chemosensitizes Tumor Cells through Interaction with Cysteine 179 of IκBα Kinase, Leading to Suppression of NF-κB–Regulated Gene Products (2014) (43)
Nuclear factor-kappa B links carcinogenic and chemopreventive agents. (2009) (43)
Embelin Suppresses Osteoclastogenesis Induced by Receptor Activator of NF-κB Ligand and Tumor Cells In vitro through Inhibition of the NF-κB Cell Signaling Pathway (2010) (42)
Mycobacterium avium-intracellulare complex activates nuclear transcription factor-kappaB in different cell types through reactive oxygen intermediates. (1998) (42)
Characterization of specific high affinity receptors for human tumor necrosis factor on mouse fibroblasts. (1985) (42)
Genetic Deletion of the Tumor Necrosis Factor Receptor p60 or p80 Sensitizes Macrophages to Lipopolysaccharide-induced Nuclear Factor-κB, Mitogen-activated Protein Kinases, and Apoptosis* (2003) (42)
Targeting Cell Survival Proteins for Cancer Cell Death (2016) (42)
Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor. (2012) (42)
Role of Cytokines and Proto‐oncogenes in Sperm Cell Function: Relevance to Immunologic Infertility (1994) (41)
Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies. (1992) (41)
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model (Molecular Cancer Therapeutics (2009) 8, (959-970)) (2009) (41)
Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1. (2009) (41)
Nuclear Transcription Factor-kappaB in Hodgkin's Disease (2003) (40)
Identification of a novel blocker of IκBα kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-κB (2008) (40)
Thiocolchicoside Exhibits Anticancer Effects through Downregulation of NF-κB Pathway and Its Regulated Gene Products Linked to Inflammation and Cancer (2010) (40)
Dietary nutraceuticals as backbone for bone health. (2018) (40)
Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells. (1992) (39)
Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis - a review (2019) (39)
Traditional uses of spices: An overview (2009) (39)
Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors. (2011) (39)
Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes (2013) (38)
Characterization and affinity cross-linking of receptors for human recombinant lymphotoxin (tumor necrosis factor-beta) on a human histiocytic lymphoma cell line, U-937. (1989) (38)
PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. (2006) (38)
Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B. (1995) (37)
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. (2005) (37)
Human lymphotoxin. (1985) (36)
γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules (2016) (35)
Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-κB Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-β (Lymphotoxin) (2019) (35)
Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: Comparison with TNF-α (2017) (35)
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases. (2007) (34)
[33] Human lymphotoxin (1985) (34)
Chronic Diseases Caused by Chronic Inflammation Require Chronic Treatment: Anti-inflammatory Role of Dietary Spices (2014) (34)
PTEN down regulates AP-1 and targets c-fos in human glioma cells Via PI3-kinase/Akt pathway (2007) (34)
Curcumin: A component of the golden spice, targets multiple angiogenic pathways (2011) (34)
Modulation of receptors and cytotoxic response of tumor necrosis factor-alpha by various lectins. (1986) (33)
Interleukin 4 potentiates the antiproliferative effects of tumor necrosis factor on various tumor cell lines. (1991) (33)
116. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway (2009) (33)
Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-κB Activation and Suppresses Apoptosis Induced by TNF (2004) (33)
Inhibition of ligand binding and antiproliferative effects of tumor necrosis factor and lymphotoxin by soluble forms of recombinant P60 and P80 receptors. (1992) (33)
The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo. (2010) (33)
Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha. (2000) (33)
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. (2008) (32)
Antiproliferative Effects of IFN-α Correlate with the Downregulation of Nuclear Factor-κB in Human Burkitt Lymphoma Daudi Cells (2001) (32)
Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors. (1996) (31)
Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB. (1999) (31)
Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester. (1993) (31)
Activation of NF-κB by RANK Requires Tumor Necrosis Factor Receptor-associated Factor (TRAF) 6 and NF-κB-inducing Kinase (1999) (31)
Down-modulation of cell surface expression of p80 form of the tumor necrosis factor receptor by human immunodeficiency virus-1 tat gene. (1992) (30)
Determination and regulation of nitric oxide production from macrophages by lipopolysaccharides, cytokines, and retinoids. (1996) (30)
Human Chorionic Gonadotropin Suppresses Activation of Nuclear Transcription Factor-κB and Activator Protein-1 Induced by Tumor Necrosis Factor* (2000) (30)
Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression. (2006) (30)
1 Resveratrol: A Polyphenol for All Seasons (2006) (30)
Modification of the cysteine residues in I B kinase and NF-B ( p 65 ) by xanthohumol leads to suppression of NF-B – regulated gene products and potentiation of apoptosis in leukemia cells (2009) (30)
Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression. (1998) (30)
Epidermal growth factor down‐regulates the expression of neutrophil gelatinase‐associated lipocalin (NGAL) through E‐cadherin in pancreatic cancer cells (2011) (30)
Effect of tumor necrosis factors, interferons, interleukins, and growth factors on the activation of NF-kappa B: evidence for lack of correlation with cell proliferation. (1994) (30)
Regulation of the activation of nuclear factor kappaB by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and -independent pathways. (2002) (30)
Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation. (1996) (29)
Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene. (1996) (29)
Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa. (2001) (29)
Calebin A Potentiates the Effect of 5-FU and TNF-β (Lymphotoxin α) against Human Colorectal Cancer Cells: Potential Role of NF-κB † (2020) (29)
Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. (1997) (27)
Purification and characterization of early pregnancy factor from human pregnancy sera. (1989) (27)
Sethi G, Ahn KS, Pandey MK, Aggarwal BB. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood. 2007;109(7):2727-2735. (2013) (27)
Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages. (2008) (27)
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: Modulation of migration and invasion of human malignant glioma cells (1999) (27)
Serum cytokine levels in infectious mononucleosis at diagnosis and convalescence. (1998) (27)
Nuclear factor-&kgr;B as a predictor of treatment response in breast cancer (2003) (27)
Butein, a tetrahydroxychalcone, suppresses cancer‐induced osteoclastogenesis through inhibition of receptor activator of nuclear factor‐kappaB ligand signaling (2011) (27)
Regulation of two forms of the TNF receptors by phorbol ester and dibutyryl cyclic adenosine 3',5'-monophosphate in human histiocytic lymphoma cell line U-937. (1993) (26)
Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it (2019) (26)
Zyflamend, a Polyherbal Preparation, Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis Through Down-Regulation of NF-κ B Activation and NF-κ B–Regulated Gene Products (2007) (26)
1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway. (2011) (26)
Dihydroxypentamethoxyflavone Down-Regulates Constitutive and Inducible Signal Transducers and Activators of Transcription-3 through the Induction of Tyrosine Phosphatase SHP-1 (2011) (26)
Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes. (1997) (26)
Assay for redox-sensitive kinases. (1999) (25)
Evidence That Curcumin Suppresses the Growth of Malignant Gliomas In Vitro and In Vivo Through Induction of Autophagy : Role of Akt and ERK Signaling Pathways (2007) (25)
Constitutive Activation of NF-κB Causes Resistance to Apoptosis in Human Cutaneous T Cell Lymphoma HuT-78 Cells (1998) (25)
Interaction of equine luteinizing hormone with binding sites for follicle-stimulating hormone in the rat seminiferous tubule. (1980) (25)
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway. (2011) (25)
Microtiter plate radioreceptor assay for tumor necrosis factor and its receptors in large numbers of samples. (1992) (25)
Cell density‐dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response (1994) (25)
Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells. (1994) (25)
Crotepoxide Chemosensitizes Tumor Cells through Inhibition of Expression of Proliferation, Invasion, and Angiogenic Proteins Linked to Proinflammatory Pathway* (2010) (24)
Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response. (1994) (24)
The Double-Stranded RNA-Activated Protein Kinase Mediates Radiation Resistance in Mouse Embryo Fibroblasts through Nuclear Factor κB and Akt Activation (2007) (24)
Calebin A, a novel component of turmeric, suppresses NF-κB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization. (2017) (24)
Expression of nuclear transcription factor kappa B in locally advanced human cervical cancer treated with definitive chemoradiation. (2010) (24)
Tumor necrosis factor-alpha exhibits greater proinflammatory activity than lymphotoxin in vitro. (1990) (24)
Molecular mechanisms in Barrett's metaplasia and its progression. (2007) (23)
Recombinant DNA-derived methionyl human growth hormone is similar in membrane binding properties to human pituitary growth hormone. (1982) (23)
Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-κB Activation and NF-κB-Regulated Antiapoptotic Gene Products1 (2007) (23)
A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways. (2010) (23)
Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer. (2009) (23)
Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway. (2012) (23)
The p80 TNF receptor‐associated kinase (p80TRAK) associates with residues 354–397 of the p80 cytoplasmic domain: similarity to casein kinase (1997) (22)
Biochemical properties of equine chorionic gonadotrophin from two different pools of pregnant mare sera. (1980) (22)
Chemical and Biological Properties of Human Lymphotoxin (1984) (22)
Calebin A downregulates osteoclastogenesis through suppression of RANKL signalling. (2016) (22)
Both type I and type II interferons down‐regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2 (1994) (22)
Characterization of the apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells. (1995) (22)
The past, present and future of multi-targeted cancer treatment "naturally": food for thought. (2008) (21)
1′-Acetoxychavicol Acetate Inhibits RANKL–Induced Osteoclastic Differentiation of RAW 264.7 Monocytic Cells by Suppressing Nuclear Factor-κB Activation (2006) (21)
Relationship of sialic acid residues to in vitro biological and immunological activities of equine gonadotropins. (1981) (21)
TNF and its receptor antibody agonist differ in mediation of cellular responses. (1994) (21)
Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2 (2020) (21)
Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages. (2007) (21)
Human tumour necrosis factors: structure and receptor interactions. (1987) (21)
Antiproliferative effects of IFN-alpha correlate with the downregulation of nuclear factor-kappa B in human Burkitt lymphoma Daudi cells. (2001) (21)
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model (International Journal of Cancer (2009) 125, (2187-2197)) (2010) (20)
Effect of visible light on the mitochondrial inner membrane. (1976) (20)
Ectopic expression of protein tyrosine kinase Bcr-Abl suppresses TNF-induced NF-κB activation and IκBα phosphorylation: Relationship with downregulation of TNF receptors (2002) (20)
All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells. (2000) (20)
Bcl-xL Suppresses TNF-Mediated Apoptosis and Activation of Nuclear Factor-κB, Activation Protein-1, and c-Jun N-Terminal Kinase (2000) (20)
Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor a in NIH 3T3 cells (gene amplification/receptor transmodulation/tumorigenesis) (20)
Vesnarinone Suppresses TNF-Induced Activation of NF-κB, c-Jun Kinase, and Apoptosis1 (2000) (20)
Role of sulfhydryl groups in induction of cell surface down-modulation and shedding of extracellular domain of human TNF receptors in human histiocytic lymphoma U937 cells. (1994) (20)
3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in IκBα Kinase, Leading to Down-regulation of Nuclear Factor-κB (NF-κB)-regulated Gene Products and Sensitization of Tumor Cells* (2011) (19)
Anti-inflammatory Nutraceuticals and Chronic Diseases (2016) (19)
N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. (2005) (19)
P80 form of the human tumor necrosis factor receptor is involved in DNA fragmentation (1993) (19)
Tumor necrosis factors - TNF-α and TNF-β: Their structure and pleiotropic biological effects (1987) (19)
The relationship between inflammation and cancer is analogous to that between fuel and fire. (2011) (19)
Regulation of Inflammation-Mediated Chronic Diseases by Botanicals (2012) (19)
Comparative analysis of the structure and function of TNF-alpha and TNF-beta. (1992) (18)
Inhibition of IkB kinase and NF-kappaB by a novel synthetic compound SK 2009. (2010) (18)
Inhibition of Radiation-Induced DNA Repair and Prosurvival Pathways Contributes to Vorinostat-Mediated Radiosensitization of Pancreatic Cancer Cells (2010) (18)
RANKL Signaling and Osteoclastogenesis Is Negatively Regulated by Cardamonin (2013) (18)
Autocrine lymphotoxin production in Epstein–Barr virus-immortalized B cells: induction via NF-κB activation mediated by EBV-derived latent membrane protein 1 (2003) (18)
Delivery of anti-inflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer (2011) (17)
Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling. (2004) (17)
Glioma cells deficient in urokinase plaminogen activator receptor expression are susceptible to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis. (2001) (17)
Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor. (1990) (17)
Curcumin and pancreatic cancer: Phase II clinical trial experience (2007) (17)
Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents. (2003) (17)
Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine‐331 in the p60 TNF receptor and inactivates the receptor‐associated kinase (1997) (17)
Modification of cysteine 179 of IκBα kinase by nimbolide leads to down-regulation of NF-κB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents. (2012) (17)
Inflammation and Cancer (2014) (17)
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. (2007) (17)
Role of tumor necrosis factor receptors in the activation of nuclear factor kappa B in human histiocytic lymphoma U-937 cells. (1994) (16)
Suramin blocks binding of interleukin-4 to its receptors on human tumor cells and interleukin-4-induced mitogenic response. (1995) (16)
Current research in biotechnology: Exploring the biotech forefront (2019) (16)
Human chorionic gonadotropin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 induced by tumor necrosis factor. (2000) (16)
PARP cleavage and caspase activity to assess chemosensitivity. (2005) (16)
The Role of Curcumin in Modern Medicine (2009) (15)
Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase. (2000) (15)
Qualitative and quantitative differences in the cellular responses mediated through Fas antigen and tumor necrosis factor receptor. (1996) (15)
Purification and characterization of donkey chorionic gonadotrophin. (1980) (15)
Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells. (1995) (15)
Interferon-gamma induces cell surface expression for both types of tumor necrosis factor receptors. (1992) (15)
Nuclear factor-kappa B as a predictor of treatment response in breast cancer. (2003) (15)
Modulation of the growth of transformed cells by human tumor necrosis factor-alpha and interferon-gamma. (1987) (15)
Upside and Downside of Tumor Necrosis Factor Blockers for Treatment of Immune/Inflammatory Diseases. (2019) (15)
Vesnarinone suppresses TNF-induced activation of NF-kappa B, c-Jun kinase, and apoptosis. (2000) (15)
Ovarian actions of tumor necrosis factor-alpha (TNF alpha): pleiotropic effects of TNF alpha on differentiated functions of untransformed swine granulosa cells. (1991) (14)
Curcumin and colorectal cancer: Add spice to your life (2009) (14)
Studies on the disappearance of equine chorionic gonadotropin from the circulation in the rat: tissue uptake and degradation. (1981) (14)
Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors. (2002) (14)
Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells (2021) (14)
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. (2016) (14)
Mending the bones with natural products. (2007) (13)
Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors (1995) (13)
Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug (2012) (13)
Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone. (1999) (13)
Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products. (2007) (13)
C5-curcuminoid-dithiocarbamate based molecular hybrids: synthesis and anti-inflammatory and anti-cancer activity evaluation (2014) (13)
Editorial: Balancing Tumor Necrosis Factor Receptor I and Tumor Necrosis Factor Receptor II Jointly for Joint Inflammation (2014) (13)
Cancer Prevention and Therapy (2014) (13)
Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia (2016) (12)
Turmeric, the Golden Spice (2011) (12)
The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma. (2010) (12)
apoptosis through modulation of the nuclear factor-κB signaling pathway (2007) (12)
Agents Activation Induced by Various Inflammatory B κ the Nuclear Transcription Factor NF-- Melanocyte-Stimulating Hormone Inhibits α (1998) (12)
Purification and characterization of the gonadotropin secreted by cultured horse trophoblast cells. (1980) (12)
pp60ν‐src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor (1994) (12)
Multi-Targeted Approach to Treatment of Cancer (2015) (11)
Role of NF-κB and NF-κB-regulated gene products in chemoresistance and radioresistance (2006) (11)
Erratum: Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-κB signalling (International Journal of Cancer (2004) 111 (679-692)) (2004) (11)
TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation. (2010) (11)
Effect of the alpha subunit of equine LH on the FSH induced cAMP production in rat seminiferous tubule cells. (1981) (11)
Micronutrients and Cancer: Add Spice to Your Life (2012) (11)
Nuclear factor-κB: a transcription factor for all seasons (2007) (11)
Phase I study of tumor necrosis factor plus actinomycin D in patients with androgen-independent prostate cancer. (1995) (11)
Multi-targeted approach to cancer treatment: an international translational cancer research symposium. (2014) (11)
Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through (2007) (10)
Characterization of recombinant human lymphotoxin (tumor necrosis factor-beta) produced by a mammalian cell line. (1989) (10)
Therapeutic Potential of Curcumin Derived from Turmeric (Curcuma longa) (2004) (10)
Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment (2021) (10)
Transfection of cells with transforming growth factor‐α leads to cellular resistance to the antiproliferative effects of tumor necrosis factor (1994) (10)
Pathways Linked to Cancer Chemoresistance and Their Targeting by Nutraceuticals (2018) (10)
Drug Discovery from Mother Nature (2016) (10)
Chapter 5 – Chemosensitization by Ursolic Acid: A New Avenue for Cancer Therapy (2018) (10)
Nuclear factor-kappa B: a transcription factor for all seasons. (2007) (9)
Characterization and mechanistic studies of a novel melanoma-targeting construct containing IκBa for specific inhibition of nuclear factor-κB activity. (2010) (9)
Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Activation of Cigarette Smoke-Induced Nuclear Factor (NF)-κB by Suppressing Activation of I-κB α Kinase in Human Non-Small Cell Lung Carcinoma (2004) (9)
Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells. (1987) (9)
Inflammation, Lifestyle and Chronic Diseases : The Silent Link (2011) (9)
Lack of requirement of STAT1 for activation of nuclear factor‐κB, c‐Jun NH2‐terminal protein kinase, and apoptosis by tumor necrosis factor‐α (2002) (9)
Plasma clearance and tissue uptake of native and desialylated equine gonadotropins (1985) (9)
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors. (2016) (9)
Leading to TNF-Induced MAPK Activation, TNF Activates Syk Protein Tyrosine Kinase (2004) (9)
Role of ceramide in tumour necrosis factor-mediated apoptosis and nuclear factor-kappa B activation. (1997) (9)
A pilot double-blind, randomized, placebo-controlled trial of curcumin/bioperine for lung cancer chemoprevention in patients with chronic obstructive pulmonary disease (2013) (9)
Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet‐derived growth factor B/c‐sis gene (1995) (8)
Emerging molecular targets in esophageal cancers. (2007) (8)
Multitargeting by Curcumin as Revealed by Molecular Interaction Studies (2012) (8)
Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric (2017) (8)
Characterization of receptors for recombinant human tumor necrosis factor-alpha from human placental membranes. (1990) (8)
Turmeric as Cure-Cumin: Promises, Problems, and Solutions (2008) (8)
Forecasting Nutrition Research in 2020 (2014) (8)
Induction of chromosomal rearrangement by tumor necrosis factors produced by primary B lymphoblastoid cells derived from cancer patients. (1993) (8)
Correction: Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL (Journal of Biological Chemistry (2010) 285 (35418-35427)) (2016) (7)
Suppression of NF-and Inhibits Cellular Invasion through Kinase That Enhances Cellular Apoptosis α B κ Identification of a Novel Blocker of (2005) (7)
Cytotoxins and Immunotoxins for Cancer Therapy : Clinical Applications (2004) (7)
γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. (2016) (7)
Evidence for a synergistic role of two types of human tumor necrosis factor receptors for the ligand-dependent activation of the nuclear transcription factor NF-kappaB. (1998) (7)
Cellular resistance to vincristine suppresses NF-kappa B activation and apoptosis but enhances c-Jun-NH2-terminal protein kinase activation by tumor necrosis. (1999) (6)
Cytotoxins and immunotoxins for cancer therapy (2015) (6)
Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma (2021) (6)
Differential Requirement for p56 in HIV-tat Versus TNF-Induced Cellular Responses: Effects on NF- kB, Activator Protein-1, c-Jun N-Terminal Kinase, and Apoptosis (2000) (6)
Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα (2015) (6)
Natural Agents That Can Sensitize Tumor Cells to Chemotherapy and Radiation Therapy (2008) (6)
2607 : Curcumin Enhances Colorectal Cancer Cell Radiosensitivity by Suppressing the Radiation-Induced Nuclear Factor-kappaB (NF-kB) Pathway (2006) (6)
Suppression of COX-2 Synthesis Lung Carcinoma : Correlation with Kinase and Akt in Human Non-Small Cell α B κ through Inhibition of Activation of I B Activation κ Abrogates TNF-Induced NF-Cyclooxygenase ( COX )-2 Inhibitor Celecoxib (2004) (6)
RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents (2010) (6)
Zerumbone, a Sesquiterpene from Southeast Asian Edible Ginger Sensitizes Colorectal Cancer Cells to Radiation Therapy (2010) (5)
Effects of histidine modification on the biological and immunological activities of equine chorionic gonadotropin. (1980) (5)
The Potential Role of Curcumin for Treatment of Pancreatic Cancer (2012) (5)
Transfection of cells with basic fibroblast growth factor and Kaposi fibroblast growth factor genes induce resistance to and receptor modulation of tumor necrosis factor (1995) (5)
Subunits of an avian (ostrich) follicle-stimulating hormone and their hybridization with subunits of mammalian gonadotropins. (1983) (5)
Immunonutrition : Interactions of Diet, Genetics, and Inflammation (2014) (5)
Balancing TNFR 1 and TNFR 2 Jointly for Joint Inflammation (2014) (5)
Lymphotoxin and tumor necrosis factor: qualitative and quantitative differences in their receptors and signal transduction in various cell types. (1990) (5)
Resistance of Ha-ras oncogene-induced progressor tumor variants to tumor necrosis factor and interferon-gamma. (1992) (5)
Role of histidine residues in ovine lutropin: effects on steroidogenic activity. (1979) (5)
The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma. (2012) (5)
Could Antitumor Activity of Curcumin in Patients Be due to Its Metabolites? A Response (2009) (5)
Ectopic Expression of Protein-tyrosine Kinase Bcr-Abl Suppresses Tumor Necrosis Factor (TNF)-induced NF-κB Activation and IκBα Phosphorylation (2002) (5)
Cellular resistance to vincristine suppresses NF-κB activation and apoptosis but enhances c-Jun-NH2-terminal protein kinase activation by tumor necrosis factor (1999) (5)
Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells. (1998) (4)
Chronic diseases caused by chronic inflammation require chronic treatment: The anti-inflammatory lifestyle (2016) (4)
Proceedings of the Indo-U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival (2013) (4)
Tumor necrosis factors (TNF): A double-edged sword (2000) (4)
Cytokines as biological regulators of homeostasis. (1998) (4)
Targeting inflammatory pathways for chronic diseases by phytochemicals derived from spices, fruits, vegetables, and traditional remedies. (2009) (4)
Erratum: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor (Journal of Molecular Medicine (2010) 88: 12 (1243-1253) DOI: 10.1007/s00109-010-0669-3) (2013) (4)
A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of I (cid:1) B Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents (2011) (4)
Editor's Note: Curcumin Potentiates the Antitumor Effects of Bacillus Calmette-Guerin against Bladder Cancer through the Downregulation of NF-κB and Upregulation of TRAIL Receptors. (2018) (4)
All pathways to cancer apoptosis meeting in Thiruvananthapuram (India) (2006) (4)
Transcription factors as targets for drug development (2002) (4)
Erratum: Nuclear transcription factor-kappaB in Hodgkin's disease (Leukemia & Lymphoma (2003) vol. 44 (6) (929-935)) (2003) (4)
Nuclear Factor-κB and Chemoresistance: How Intertwined Are They? (2009) (4)
414 A Novel Small Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth Both In Vitro and In Vivo (2010) (4)
Induction of interleukin-2 receptor by tumor necrosis factor α on cultured ovarian tumor-associated lymphocytes (1992) (3)
Reversal of Chemoresistance and Enhancement of Apoptosis by Statins Through Downegulation of the NF- κ B pathway (2009) (3)
Erratum: Imatinib Mesylate Resistance Through BCR-ABL Independence in Chronic Myelogenous Leukemia (Cancer Research (January 15, 2004) (672-677)) (2004) (3)
Differences in the Biological Responses and the Structure of Lymphotoxin and Tumor Necrosis Factor (1990) (3)
Correction: Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors (Journal of Biological Chemistry (2010) 285, (11498-11507)) (2016) (3)
Evolution of Innate and Adaptive Immunity (2014) (3)
Curcumin, the Holistic Avant-Garde (2017) (3)
TNF- a -Induced Mitochondrial Alterations in Human T Cells Requires FADD and Caspase-8 Activation but Not RIP and Caspase-3 Activation (2010) (3)
Response to Kurien and Scofield: Solubility and bioavailability of curcumin (2009) (3)
Chronic Inflammation and Cancer: A Matter of Lifestyle (2012) (3)
Curcuminoids from Curcuma Longa in the Fight against Cancer and Age Related Disorders (2008) (3)
Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. (2016) (3)
Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor (2005) (3)
Gamma tocotrienol and prostate cancer: The regulation of two independent pathways to potentiate cell growth inhibition and apoptosis (2008) (2)
Correction: Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway. (2019) (2)
Downregulation of integrin α v β 3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense uPAR and sense p 16 genes (2001) (2)
Prevention and Treatment of Neurodegenerative Diseases by Spice-Derived Phytochemicals (2009) (2)
Mechanisms of Regulation of Cell Growth by Cytokines of the Immune System (1994) (2)
Capsaicin induces G1/S cell cycle arrest leading to apoptosis of multiple myeloma cells through suppression of STAT3 activation and STAT3-regulated gene products. (2006) (2)
Natural Compounds Targeting STAT3 Mediated Inflammation. (2016) (2)
Curcumin: The Biochemistry Behind Its Anticancer Effects (2009) (2)
Multifunctionality of Calebin A in inflammation, chronic diseases and cancer (2022) (2)
Recombinant Organisms as Source of Cancer Biotherapeutics (1998) (2)
IL-13 Suppresses TNF-Induced Activation of Nuclear Factor-κB, Activation Protein-1, and Apoptosis (1998) (2)
Association of activated NF-kB, altered cyclin D1 and poor outcome in esophageal adenocarcinoma (2005) (2)
pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor. (1994) (2)
10 TNF Blockade : An Inflammatory Issue (2005) (2)
Retraction notice to “Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo” [Biochem. Pharmacol. 79 (2010) 330–338]. (2016) (2)
3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells. (2016) (2)
Retraction notice to "Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo" [Biochem. Pharmacol. 79 (2010) 330-338]. (2016) (2)
Lessons to Be Learnt from Ayurveda (2020) (2)
Genome-Based Multi-targeting of Cancer: Hype or Hope? (2015) (2)
Leaders in Translational Cancer Research Meet in Udaipur, a Historical Town of India: An International Symposium on Translational Cancer Research: Cancer Prevention. Udaipur, Rajasthan, India, December 16-19, 2011 (2013) (1)
Retraction notice to “Thymoquinone poly(lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential” [Biochem. Pharmacol. 79 (2010) 1640–1647]. (2016) (1)
City of temples discusses signaling templates in cancer cells. Third International Symposium on Translational Cancer Research: Cell Signaling & Cancer Therapy. Bhubaneswar, Orissa, India, December 18th through 21st, 2009. (2010) (1)
Molecular Targets of Curcumin (2007) (1)
Abstract 1618: Erythropoietin meets a new receptor (2011) (1)
Independence in Chronic Myelogenous Leukemia Imatinib Mesylate Resistance Through BCR-ABL (2004) (1)
Erratum: Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-κB, but not c-Jun N-terminal kinase and activated protein-1 (Molecular Carcinogenesis (2005) 45 (26-37)) (2006) (1)
Retraction notice to “Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines” [Biochem. Pharmacol. 73 (2007) 1024–1032]. (2016) (1)
Spices and Dietary Supplements with Anti-Inflammatory Activity (2014) (1)
Copper complexes of henna-sulforaphane conjugates as potent antiproliferative agents against human myeloma KBM-5 cells through blockade of transcription factor NF-κB (2007) (1)
Emodin (3-methyl-1,6,8-trihydroxy- anthraquinone) inhibits TNF-induced NF-kB activation, IkB degradation, and expression of cell surface adhesion proteins in human vascular endothel.. (2015) (1)
Retraction: Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins (2018) (1)
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells (2012) (1)
Abstract PR-09: Low-fat diet reduces NF-κB regulated inflammatory cytokines and angiogenic factors in plasma of men with prostate cancer (2010) (1)
Preface: NF-κB, Immune System and Chronic Diseases: How Are They Linked? (2013) (1)
In vitro selection of NIH-3T3 cells for resistance to lymphotoxin induces resistance to activated macrophages and enhances tumorigenicity in vivo. (1991) (1)
WITHDRAWN: Cardamonin Inhibits Osteoclastogenesis Induced by Tumor Cells Through Interruption of the Signaling Pathway Activated by Receptor Activator of NF-κB Ligand. (2011) (1)
leading to suppression of proliferation and induction of apoptosis kinase in human multiple myeloma cells α B κ B and I κ nuclear factor Curcumin (Diferuloylmethane) downregulates the constitutive activation of (2013) (1)
Targeting inflammatory pathways by dietary agents for prevention and therapy of cancer (2020) (1)
Purification and characterization of lymphotoxin from human lymphoblast cell line 1788 (1982) (1)
Erratum: Acetyl-11-keto-b-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression (International Journal of Cancer (2011) 129: 1 (23-33) DOI: 10.1002/ijc.25966) (2015) (1)
Advances in Brief Human Immunodeficiency Virus Type 1 tat Gene Upregulates Interleukin 4 Receptors on a Human B-Lymphoblastoid Cell Line (2006) (1)
TISSUE TRANSGLUTAMINASE DOWNREGULATION POTENTIATES GEMCITABINE EFFICACY AND BLOCKS PANCREATIC CANCER GROWTH AND METASTASIS IN VIVO (2007) (1)
Acetyl-11-Keto- B -Boswellic Acid Inhibits Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2–Mediated Angiogenesis Experimental Therapeutics, Molecular Targets, and Chemical Biology (2009) (1)
Curcumin for Prevention and Treatment of Chronic Diseases: An Overview of the Clinical Studies and Evidence-Based Support (2014) (1)
DNA Damage and Cancer Chemoprevention by Polyphenols (2009) (1)
Role of Protein Kinases and Phosphatases in Receptor Biosynthesis, Shedding and Mediation of Cellular Responses to Tumor Necrosis Factor (1993) (1)
Lack of requirement of STAT1 for activation of nuclear factor-kappaB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-alpha. (2002) (1)
Review Article Cancer-linked targets modulated by curcumin (2012) (1)
Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway. (2016) (1)
Increased lymphotoxin in human malarial serum: Its ability to increase plasma interleukin-6 and cause hypoglycemia, and possible role in malaria (1991) (1)
multiple myeloma cells B-regulated antiapoptotic and cell survival gene products in human κ chemoresistance through downregulation of STAT3 and nuclear factor- Resveratrol inhibits proliferation, induces apoptosis and overcomes (2013) (1)
kappa } B and Osteoclastogenesis by Suppressing Invasion , and Abolishes Potentiates Apoptosis , Inhibits Acetyl-11-Keto-beta-Boswellic Acid (2006) (0)
Abstract 5008: Epidermal growth factor downregulates expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells (2011) (0)
Retraction notice to "Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake" [Biochem. Pharmacol. 80 (2010) 1021-1032]. (2016) (0)
Cancer Therapy : Preclinical Nimbolide , a Limonoid Triterpene , Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proin fl ammatory Microenvironment (2013) (0)
Advances in Experimental Medicine and Biology: Preface (2007) (0)
colchicoside Exhibits Anticancer Effects through nregulation of NF-κB Pathway and Its Regulated Gene (2010) (0)
An isolated biologically active human lymphotoxinderiv and the antibody which neutralizes the cytolytic activity of this, nucleic acid encoding the lymphotoxinderivatet, replicable vector comprising the nucleic acid heterologous cell transformed with the nucleic acid and the method which comprises p (1985) (0)
Chapter 9 Human cytokines (1996) (0)
Transcription factor NFkB a potential molecular marker for predicting and improving treatment efficacy in esophageal cancer. (2006) (0)
Abstract 4457: In Search of a novel EPO receptor: The clinical significance of the Eph connection (2011) (0)
A pharmaceutical composition for inhibiting tumor cell growth (1984) (0)
Editor's Note: γ-Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment. (2018) (0)
Abstract B261: A novel small molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vivo (2009) (0)
Chemoprevention of GI Cancers with Dietary Agents : Are We There Yet ? Fruits (0)
Kinase and Activator Protein-1 HIV-Tat Protein Activates c-Jun N-Terminal (1998) (0)
InVivoInduction ofNitrite andNitrate byTumorNecrosis Factor, Lymphotoxin, andInterleukin-1: Possible RolesinMalaria (1992) (0)
Abstract 1583: Plumbagin, a medicinal plant-derived naphthoquinone with both chemopreventive and therapeutic properties, selectively inhibits expression of Protein Kinase Cε, a predictive biomarker of prostate cancer progression (2010) (0)
Acknowledgement to reviewers 2009 (2009) (0)
Anti-lymphotoxin antibody, preparation and use (1985) (0)
Human Chorionic Gonadotropin Suppresses Activation of Nuclear Transcription Factor-kB and Activator Protein-1 Induced by Tumor Necrosis Factor* (2000) (0)
and differentiation induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, Protease inhibitors differentially regulate tumor necrosis factor- (2011) (0)
Abstract #2759: Thymoquinone-induced E2F-1 downregulation and induction of apoptosis enhances gemcitabine effects in pancreatic cancer (2009) (0)
Pseudomonas exotoxin-based immunotoxins/cytotoxins (2005) (0)
The recombinant lymphotoxin (1985) (0)
Activated Kinase-1 β Kinase and TGF-α B κ Products : Role of I B-Dependent Antiapoptotic Gene κ NF-Apoptosis through the Down-Regulation of-Induced α Simvastatin Potentiates TNF - (2007) (0)
Role of protein tyrosine phosphorylation in tnf-mediated nf-kb activation and growth modulation (1997) (0)
Retraction Notice (2019) (0)
FIGURE 13.1, [(See color insert.) Different species...]. (2011) (0)
Abstract #5538: Reversal of chemoresistance and enhancement of apoptosis by curcumin through down-regulation of the NF-kappaB pathway in Ewing\#8217;s sarcoma cells (2009) (0)
Recombinant proteins and genomics in cancer therapy (2009) (0)
belin Suppresses Osteoclastogenesis Induced by Receptor ivator of NF-κB Ligand and Tumor Cells In vitro through (2010) (0)
Rese Thio Dow Pro Simon Rama Abst Intro (2010) (0)
Role of anti-inflammatory agents in the treatment of lymphoma (2015) (0)
The rGel/BLyS fusion toxin inhibits malignant B cells and blocks endogenous NF-κB signaling pathways (2007) (0)
Effect of serine protease inhibitors on the expression of cell surface and soluble forms of two types of tumor necrosis factor receptors (1997) (0)
Association of activated transcription factor NF-kappaB with chemo-radiotherapy resistance and poor outcome in esophageal adenocarcinoma (2005) (0)
Tumor necrosis factor and derivatives and mutant forms thereof, process for their production, DNA coding therefor, replicable expression vector containing the DNA and cell transformed therewith as well as compositions comprising the tumor necrosis factor (1994) (0)
Lymphotoxin, nucleic acid encoding, cells containing the nucleic acid vectors and thus transformed, moved to get from lymphotoxin and lymphotoxin neutralizing antibodies. (1985) (0)
EFFECTS OF VISIBLE LIGHT EXPOSURE ON MITOCHONDRIAL STRUCTURE AND FUNCTION (1977) (0)
Retraction notice to "Thymoquinone poly(lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential" [Biochem. Pharmacol. 79 (2010) 1640-1647]. (2016) (0)
Cells : Delineation of a Novel Pathway B in Cancer κ Constitutive Activation of Nuclear Factor-Overexpression of Tissue Transglutaminase Leads to Updated (2006) (0)
Aldose reductase regulates reactive oxygen species mediated-inflammatory signals (2003) (0)
Retraction notice to “Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers” [Biochem. Pharmacol. 79 (2010) 218–228]. (2016) (0)
B κ invasion by suppressing nuclear factor-that enhances apoptosis and inhibits proliferation and kinase activation α B κ Identification of a novel blocker of I Updated (2008) (0)
Informetric Analysis on the International Retracted Publication Based on the Web of Science Database (2019) (0)
Anti-inflammatory life style for prevention and treatment of cancer and other chronic diseases: Facts and fiction (2013) (0)
Abstract 3865: The rGel/BLyS fusion toxin enhances the therapeutic effects of bortezomib in in vitroand in vivomodels of mantle cell lymphoma. (2012) (0)
Correction: Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthotopic Nude Mouse Model through Modulation of Multiple Targets (2012) (0)
Retraction notice to "Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers" [Biochem. Pharmacol. 79 (2010) 218-228]. (2016) (0)
Tocotrienols, inflammation, and cancer: How are they linked? (2012) (0)
Cellular Mechanisms of Cytokine Activation (2014) (0)
Expression of survival receptors in Hodgkin disease cell lines (2002) (0)
ERRATUM: Author-Reported Correction of Western Blot Data: Kim JH, Park B, Gupta SC, Kannappan R, Sung B, and Aggarwal BB. Antioxid Redox Signal 16:413–427, 2012 (2013) (0)
Tumor necrosis factor, processes for its production, compositions containing the same, daf} r-encoding DNA and this DNA-use test driving. (1985) (0)
Role of mitochondria in TNF-induced apoptosis; induction of apoptosis through inhibition of complex I (1996) (0)
Erratum to: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor (2013) (0)
Chronic diseases, inflammation, and spices: how are they linked? (2018) (0)
Osteoclast Precursors and Suppresses B Activation in κ Ligand-Induced NF- B κ Receptor Activator of NF- Curcumin (Diferuloylmethane) Inhibits (2013) (0)
Retraction notice to "Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines" [Biochem. Pharmacol. 73 (2007) 1024-1032]. (2016) (0)
Role of Curcumin, the Golden Spice, in Obesity and Associated Chronic Diseases (2012) (0)
Genetic Deletion of the TNF Receptor p 60 or p 80 in Macrophages Modulates RANKL-Induced Signaling (2004) (0)
History and Current Status of Evidence-Based Korean Medicine (2014) (0)
WITHDRAWN: Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells. (2012) (0)
Obituary: Madhu Sudan Kanungo, PhD (1927–2011) (2012) (0)
Recent developments in the chemistry and biology of human lymphotoxin (1985) (0)
Meeting report: leaders in translational cancer research meet in Udaipur, a historical town of India: an International Symposium onTranslational Cancer Research: Cancer Prevention. Udaipur, Rajasthan, India, december 16-19, 2011. (2013) (0)
A Phase I/II Study of Complementary Therapy Using Curcumin for Patients with Gemcitabine-Resistant Pancreatic Cancer (2016) (0)
Lymphotoxin: Developments during the last decade (1997) (0)
Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials (2012) (0)
Nuclear Transcription Factor-κB: A Drug Target for all Seasons (2005) (0)
Prevention and Treatment of Cancer: Hypes and Hopes 6th International Translational Cancer Research Conference. (2016) (0)
Process for the preparation of necrosis factor (1994) (0)
Divergent effects of recombinant human tumor necrosis factor alpha on cell growth in vitro (1986) (0)
Therapeutic implications of gene deletion of ligands and receptors of members of TNF superfamily (2005) (0)
21 Preventive and Therapeutic Effects of Plant Polyphenols through Suppression of Nuclear Factor-Kappa B (2005) (0)
Retraction notice to "Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: Role of Michael acceptors and Michael donors" [Biochem. Pharmacol. 82 (2011) 1901-1909]. (2016) (0)
Specific binding of recombinant DNA derived human lymphotoxin to high affinity receptors on mouse fibroblasts (1985) (0)
Recombinant variant type lymphotoxin (1995) (0)
Equine LH possesses significant intrinsic FSH activity (1979) (0)
Tocotrienols fight cancer by targeting multiple cell signaling pathways (2011) (0)
Erratum: Cardamonin sensitizes tumour cells to TRAIL through ROS and CHOP-mediated up-regulation of death receptors and down-regulation of survival proteins (British Journal of Pharmacology (2012) 165 (741-753)) (2013) (0)
Tumor Necrosis Factor and Its Family Members (2009) (0)
Process for the preparation of human tumor necrosis factor and the DNA encoding the (1985) (0)
Tyrosine 42 phosphorylation of ikba prevents its tnf-induced phosphorylation and degradation (1997) (0)
TNF-induced afoptosis is mediated through inhibition of mitochondrial respiration chain complex I (1996) (0)
Retraction: Down-regulation of integrin αvβ3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes. (2020) (0)
Retraction notice to "Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway" [Biochem. Pharmacol. 82 (2011) 1134-1144]. (2016) (0)
Tumor Necrosis Factors (2018) (0)
Retraction notice to “Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway” [Biochem. Pharmacol. 82 (2011) 1134–1144]. (2016) (0)
Tumornecrosefaktorderivater, DNA coding therefor, replicable expression vectors containing the DNA, host cells transformed therewith and to a process for the preparation of tumornecrosefaktorderivaterne as well as compositions comprising tumornecrosefaktorderivaterne (1994) (0)
Synergistic Antiproliferative Effects of TNF and IL-4 against Various Tumor Cell Lines (1992) (0)
Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2 (2020) (0)
3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in I (cid:1) B (cid:2) Kinase, Leading to Down-regulation of Nuclear Factor- (cid:1) B (NF- (cid:1) B)-regulated Gene Products and Sensitization of Tumor Cells * (2020) (0)
Functional expression of RANK in Hodgkin disease cell lines Regulation of chemokine and cytokine expression (2001) (0)
GUGGULSTERONE EN TANT QU'INHIBITEUR DU FACTEUR NUCLEAIRE KB ET DE L'ACTIVATION DE L'IKB KINASE-ALPHA (2006) (0)
Nuclear factor– (cid:1) B and STAT3 are constitutively active in CD138 (cid:2) cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis (2004) (0)
Development of new biologics: Views of the future (1991) (0)
ocotrienol Inhibits Pancreatic Tumors and Sensitizes m to Gemcitabine Treatment by Modulating the R mmatory Microenvironment (2010) (0)
ACMAP 6th Annual Conference Spokane-WA (2020) (0)
Erratum to: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor (2013) (0)
dna encoding the recombinant lymphotoxin (1995) (0)
Lymphotoxin, nucleic acid coding therefor, vectors containing the nucleic acid and thus transformed cells, processes for obtaining lymphotoxin and lymphotoxin neutralizing antibody. (1985) (0)
Modulation of Proteasome Pathways by Nutraceuticals (2013) (0)
Correction to "Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-κB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IκBα kinase activation" (Molecular Pharmacology (20 (2012) (0)
Abstract LB-177: A supercritical turmeric extract prevents small intestinal and colonic tumors in the APCMin/+ mice by suppressing proliferation and cancer stem cell markers (2012) (0)
Metalloproteinase 9 , and Cyclin D 1 Down-Regulation of Cyclooxygenase 2 , Matrix Kinase and p 65 Phosphorylation : Correlation with α B κ by Carcinogenic Agents through Suppression of I B Activation Induced κ Ursolic Acid Inhibits Nuclear Factor-Updated (2003) (0)
Myeloma Cells Phosphorylation in Human Multiple Constitutive and IL-6-Inducible STAT3 Curcumin (Diferuloylmethane) Inhibits (2003) (0)
Effects of Natural Polyphenols on Chemoradiotherapy in Cancer (2010) (0)

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