Bik Kwoon Tye | Academic Influence

Bik Kwoon Tye's AcademicInfluence.com Rankings

Bik Kwoon Tye

Biology

#11721

World Rank

#15142

Historical Rank

Cell Biology

#799

World Rank

#818

Historical Rank

Genetics

#1582

World Rank

#1688

Historical Rank

Neuroscience

#2405

World Rank

#2470

Historical Rank

biology Degrees

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Biology

Bik Kwoon Tye's Degrees

Bachelors Biology University of California, Berkeley
PhD Molecular Biology Stanford University

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Why Is Bik Kwoon Tye Influential?

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According to Wikipedia, Bik Kwoon Yeung Tye is a Chinese-American molecular geneticist and structural biologist. Tye's pioneering work on eukaryotic DNA replication led to the discovery of the minichromosome maintenance genes in 1984, which encode the catalytic core of the eukaryotic replisome. Tye also determined the first high-resolution structures of both the MCM complex and the Origin Recognition Complex in 2015 and 2018. Tye is currently a Professor Emeritus at Cornell University and a visiting professor at the Hong Kong University of Science & Technology. She is married to Henry Sze-Hoi Tye and is the mother of Kay Tye and Lynne Tye.

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Bik Kwoon Tye's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MCM proteins in DNA replication. (1999) (617)
Mutants of S. cerevisiae defective in the maintenance of minichromosomes. (1984) (404)
Initiating DNA synthesis: from recruiting to activating the MCM complex. (2001) (371)
Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. (1997) (334)
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice (2007) (316)
Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition. (1975) (296)
Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MAT alpha cells. (1988) (279)
Organization of DNA sequences and replication origins at yeast telomeres (1983) (278)
Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. (1993) (231)
Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA. (1977) (229)
Unusual DNA sequences associated with the ends of yeast chromosomes (1984) (217)
Structure of the eukaryotic MCM complex at 3.8 Å (2015) (211)
A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes. (1989) (204)
Non-random circular permutation of phage P22 DNA. (1974) (201)
Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae (1996) (196)
Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. (2000) (192)
Autonomously replicating sequences in Saccharomyces cerevisiae. (1980) (183)
Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. (1991) (165)
A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae (1997) (165)
Uracil incorporation: a source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome. (1978) (134)
The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication (1990) (126)
The MCM2-3-5 proteins: are they replication licensing factors? (1994) (122)
The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings (2002) (104)
Packaging of an oversize transducing genome by Salmonella phage P22. (1974) (103)
A family of Saccharomyces cerevisiae repetitive autonomously replicating sequences that have very similar genomic environments. (1983) (102)
Identification of a telomere-binding activity from yeast. (1986) (101)
The Hexameric Eukaryotic MCM Helicase: Building Symmetry from Nonidentical Parts* (2000) (100)
Excision repair of uracil incorporated in DNA as a result of a defect in dUTPase. (1977) (97)
Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. (2003) (97)
Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae. (2004) (91)
CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences. (1992) (87)
Functional domains of the yeast transcription/replication factor MCM1. (1991) (84)
Structure of the origin recognition complex bound to DNA replication origin (2018) (83)
Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae. (1997) (80)
Identification and characterization of a nuclease activity specific for G4 tetrastranded DNA. (1993) (78)
A yeast protein that binds to vertebrate telomeres and conserved yeast telomeric junctions. (1991) (76)
Insights into DNA replication from the third domain of life. (2000) (73)
Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer (2017) (73)
Both activation and repression of a-mating-type-specific genes in yeast require transcription factor Mcm1. (1991) (70)
A mutant that affects the function of autonomously replicating sequences in yeast. (1986) (63)
Mcm1 regulates donor preference controlled by the recombination enhancer in Saccharomyces mating-type switching. (1998) (57)
Specific interaction between a Saccharomyces cerevisiae protein and a DNA element associated with certain autonomously replicating sequences. (1988) (56)
A Comprehensive Genome-Wide Map of Autonomously Replicating Sequences in a Naive Genome (2010) (55)
Hybridization with synthetic oligonucleotides. (1979) (53)
The mitotic stability of deletion derivatives of chromosome III in yeast. (1986) (49)
Evidence for a Role of MCM (Mini-chromosome Maintenance)5 in Transcriptional Repression of Sub-telomeric and Ty-proximal Genes in Saccharomyces cerevisiae* (2003) (48)
Minichromosome maintenance as a genetic assay for defects in DNA replication. (1999) (47)
The OBF1 protein and its DNA-binding site are important for the function of an autonomously replicating sequence in Saccharomyces cerevisiae (1989) (45)
Budding yeast mcm10/dna43 mutant requires a novel repair pathway for viability (2003) (45)
Mcm7, a Subunit of the Presumptive MCM Helicase, Modulates Its Own Expression in Conjunction with Mcm1* (2003) (43)
Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing. (2017) (42)
Genome-Wide Hierarchy of Replication Origin Usage in Saccharomyces cerevisiae (2006) (42)
Isolation and characterization of the centromere from chromosome V (CEN5) of Saccharomyces cerevisiae (1984) (42)
Alternative Mechanisms for Coordinating Polymerase α and MCM Helicase (2009) (41)
Structural insights into the Cdt1-mediated MCM2–7 chromatin loading (2011) (40)
Construction of telocentric chromosomes in Saccharomyces cerevisiae. (1985) (39)
Novel DNA Binding Properties of the Mcm10 Protein from Saccharomyces cerevisiae* (2009) (37)
Chromosome loss, hyperrecombination, and cell cycle arrest in a yeast mcm1 mutant. (1992) (37)
Resolution of dicentric chromosomes by Ty-mediated recombination in yeast. (1985) (36)
Mcm1 Binds Replication Origins* (2003) (32)
Mcm10 Is Required for the Maintenance of Transcriptional Silencing in Saccharomyces cerevisiae (2005) (32)
Mcm10 Mediates the Interaction Between DNA Replication and Silencing Machineries (2009) (31)
The yeast Mcm1 protein is regulated posttranscriptionally by the flux of glycolysis (1995) (29)
A mutant of phage P22 with randomly permuted DNA. (1976) (28)
Mcm1 Promotes Replication Initiation by Binding Specific Elements at Replication Origins (2004) (27)
Nuclear accumulation of Saccharomyces cerevisiae Mcm3 is dependent on its nuclear localization sequence (1997) (26)
Aneuploidy and Improved Growth Are Coincident but Not Causal in a Yeast Cancer Model (2009) (26)
Novel features of ARS selection in budding yeast Lachancea kluyveri (2011) (22)
An agarose gel electrophoresis assay for the detection of DNA-binding activities in yeast cell extracts. (1987) (20)
Two mcm3 Mutations Affect Different Steps in the Initiation of DNA Replication* (2002) (19)
Ploidy Dictates Repair Pathway Choice under DNA Replication Stress (2011) (17)
Humanizing the yeast origin recognition complex (2021) (17)
Structure of the MCM2-7 Double Hexamer and Its Implications for the Mechanistic Functions of the Mcm2-7 Complex. (2017) (16)
Mcm3 Is Polyubiquitinated during Mitosis before Establishment of the Pre-replication Complex* (2002) (16)
Meiotic disjunction of homologs in Saccharomyces cerevisiae is directed by pairing and recombination of the chromosome arms but not by pairing of the centromeres. (1988) (15)
Alignment of partial denaturation maps of circularly permuted DNA by computer. (1974) (13)
P22 morphogenesis. II: Mechanism of DNA encapsulation. (1974) (12)
Mcm 7 , a Subunit of the Presumptive MCM Helicase , Modulates its Own Expression in Conjunction with Mcm 1 (2003) (11)
Dual functional regulators coordinate DNA replication and gene expression in proliferating cells. (2004) (10)
Computational detection of significant variation in binding affinity across two sets of sequences with application to the analysis of replication origins in yeast (2008) (9)
Site-directed chromosomal rearrangements in yeast. (1987) (6)
Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase (2022) (6)
FUNCTIONAL COMPONENTS OF THE SACCHAROMYCES CEREVISIAE CHROMOSOMES - REPLICATION ORIGINS AND CENTROMERIC SEQUENCES (1981) (5)
Excision-repair of uracil in DNA: its implications for the discontinuous replication of DNA in vivo and in vitro. (1979) (5)
Excision repair of uracil during replication of phiX174 DNA in vitro. (1978) (5)
The human pre-replication complex is an open complex (2023) (3)
Transient accumulation ofOkazaki fragments asaresult ofuracil incorporation intonascent DNA (1977) (2)
Erratum: Unusual DNA sequences associated with the ends of yeast chromosomes (1984) (2)
Structure of the origin recognition complex bound to DNA replication origin (2018) (2)
Memories of Ray Wu by a Colleague (2009) (2)
Meiotic segregation of normal and deletion chromosomes in Saccharomyces cerevisiae. (1989) (1)
Author Correction: Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase (2022) (0)
Alternative Mechanisms for Coordinating Polymerase (cid:1) and MCM Helicase (cid:1) (2009) (0)
Uracil incorporation : A source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome ( Okazaki fragments / dUTPase / uracil N-glycosidase / discontinuous DNA replication ) (0)
Isolation andCharacterization oftheCentromere fromChromosome V (CEN5)ofSaccharomyces cerevisiae (1984) (0)
Evolution of the Eukaryotic Origin Recognition Complex (2020) (0)
Old-fashioned genetic screens give new insights to DNA replication (2010) (0)
Xviii. Cognitive Information Processing Research Objectives and Summary of Research 1. Text-to-speech Conversion (2009) (0)
Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and B1 element (2018) (0)
Mcm2 and M two proteins mportant for cAmR3S activity, are related in structure and function (2007) (0)
Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state (2017) (0)
A yeast protein that binds to vertebrate telomeres and conserved yeast telomeric junctions (2007) (0)
Xiii. Cognitive Information Processing A. Text-to-speech Conversion 1. Locally Organized Parser for Spoken Input (2009) (0)
Eukaryotic DNA Polymerase α (2013) (0)
Construction of telocentric chromo, Saccharomyces cerevisiae (chromosomal deletions/meiotic pairing/mitotic stability/fluctuation (2016) (0)
Proteins Involved in ARS Function in Yeast (1992) (0)
Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae. (1986) (0)
COMPLEXITY OF CHROMOSOMAL REPLICATION ORIGINS IN SACCHAROMYCES CEREVISIAE (1980) (0)
Excision Repair of Uracil in DNA and Its Contribution to the Pool of Okazaki Fragments (1978) (0)
ThePhenotype oftheMinichromosome Maintenance Mutantmcm3 IsCharacteristic ofMutants Defective inDNA Replication (1990) (0)
Humanizing the yeast origin recognition complex (2021) (0)
The Cell’s Toolbox for DNA Repair: The Nobel Prize in Chemistry 2015 (2015) (0)

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