Bimal Kumar Bachhawat

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#1042

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#1337

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Neurochemistry

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Bimal Kumar Bachhawat's Degrees

PhD Biochemistry University of Calcutta

Why Is Bimal Kumar Bachhawat Influential?

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According to Wikipedia, Bimal Kumar Bachhawat was an Indian neurochemist and glycobiologist, known for his discovery of HMG-CoA lyase, an intermediate in the mevalonate and ketogenesis pathway, and for the elucidation of the molecular cause of metachromatic leukodystrophy, a hereditary disease of the brain His studies on sugar-bearing liposomes led to its use as a carrier for in situ delivery of drugs and hormones to diseased organs and he pioneered the therapy of systemic fungal infections using liposomal formulations. He was a recipient of several awards including the Shanti Swarup Bhatnagar Award, the highest Indian honor in science and technology and an elected fellow of three major Indian science academies. The Government of India awarded him the third highest civilian honour of the Padma Bhushan, in 1990, for his contributions to science.

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Bimal Kumar Bachhawat's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A CONTROLLED STUDY OF ENZYMIC ACTIVITIES IN THREE HUMAN DISORDERS OF GLYCOLIPID METABOLISM * (1963) (168)
Transdermal immunisation with an integral membrane component, gap junction protein, by means of ultradeformable drug carriers, transfersomes. (1998) (142)
Interaction between lectin from Ricinus communis and liposomes containing gangliosides (1975) (125)
Abnormal sulphatase activities in two human diseases (metachromatic leucodystrophy and gargoylism). (1964) (104)
On the Specificity of Carbohydrate‐Lectin Recognition (1974) (93)
Grafting of different glycosides on the surface of liposomes and its effect on the tissue distribution of 125I-labelled gamma-globulin encapsulated in liposomes. (1980) (83)
ISOLATION AND CHARACTERIZATION OF GLYCOSAMINOGLYCANS IN HUMAN BRAIN OF DIFFERENT AGE GROUPS (1968) (82)
The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A. (1955) (81)
PURIFICATION AND PROPERTIES OF BRAIN ALKALINE PHOSPHATASE (1977) (79)
Targeting of liposomes towards different cell types of rat liver through the involvement of liposomal surface glycosides. (1982) (65)
ISOLATION AND CHARACTERIZATION OF GLYCOSAMINOGLYCANS IN BRAIN OF DIFFERENT SPECIES (1969) (56)
THE DISTRIBUTION and VARIATION WITH AGE OF DIFFERENT URONIC ACID‐CONTAINING MUCOPOLYSACCHARIDES IN BRAIN (1965) (56)
Enzymatic carboxylation of beta-hydroxyisovaleryl coenzyme A. (1956) (48)
Monosialoganglioside liposome-entrapped enzyme uptake by hepatic cells. (1977) (47)
Coenzyme A thiol esters of isobutyric, methacrylic, and beta-hydroxyisobutyric acids as intermediates in the enzymatic degradation of valine. (1957) (47)
Studies in globoid (Krabbe) leukodystrophy (GLD). V. Controlled enzymic studies in ten human cases. (1970) (46)
Formation of cerebroside sulphate from 3'-phosphoadenosine 5'-phosphosulphate in sheep brain. (1965) (44)
Tiglyl coenzyme A and alpha-methylacetoacetyl coenzyme A, intermediates in the enzymatic degradation of isoleucine. (1956) (44)
THE REGIONAL DISTRIBUTION, AGE DEPENDENT VARIATION AND SPECIES DIFFERENCES OF BRAIN ARYLSULPHATASES (1971) (43)
Affinity chromatography of galactose containing biopolymers using covalently coupled Ricinus communis lectin to Sepharose 4B. (1975) (43)
Purification, properties and glycoprotein nature of arylsulfatase A from sheep brain. (1975) (42)
Tuftsin‐bearing liposomes as drug vehicles in the treatment of experimental aspergillosis (1993) (38)
A cerebroside sulphotransferase deficiency in a human disorder of myelin. (1967) (37)
Interaction between Concanavalin A and brain lysosomal acid hydrolases (1974) (36)
ENZYMIC TRANSFER OF SULPHATE FROM 3′‐PHOSPHOADENOSINE 5′‐PHOSPHOSULPHATE TO MUCOPOLYSACCHARIDES IN RAT BRAIN * (1964) (36)
Enzymic degradation of active sulphate. (1962) (34)
PURIFICATION AND PROPERTIES OF AN ARYLSULPHATASE FROM HUMAN BRAIN * (1963) (31)
CARBON DIOXIDE FIXATION IN HEART EXTRACTS BY β-HYDROXYISOVALERYL COENZYME A1 (1954) (30)
Isolation and comparative physico-chemical studies of Concanavalin A from Canavalia ensiformis and Canavalia gladiata. (1973) (30)
The effect of surface charges of liposomes in immunopotentiation (1984) (30)
Separation of polypeptide chains of ricin and the interaction of the A chain with Cibacron Blue F3GA. (1979) (29)
Synthetic glycolipids: interaction with galactose-binding lectin and hepatic cells. (1981) (28)
Sulfate metabolism in brain. (1970) (27)
Increased circulatory half-life of liposomes after conjunction with dextran (1984) (27)
The effect of lipid composition on liposome-lectin interaction. (1978) (26)
Role of neuraminic acid in the heterogeneity of alkaline phosphatase in sheep brain. (1968) (26)
PHOSPHATASES FROM HUMAN BRAIN—I (1963) (26)
Purification and properties of arylsulphatase A from chicken brain. (1972) (25)
Purification of glucosamine 6-phosphate deaminase from human brain. (1961) (24)
Further characterization of the sialic acid-binding lectin from the horseshoe crab Carcinoscorpius rotunda cauda. (1981) (24)
Rat liver lactic dehydrogenase. I. Isolation and chemical properties of the crystalline enzyme. (1953) (24)
Binding studies of a sialic acid-specific lectin from the horseshoe crab Carcinoscorpius rotunda cauda with various sialoglycoproteins. (1982) (23)
Enzymatic desulphation of cerebroside‐3‐sulphate by chicken brain arylsulphatase A (1973) (23)
The effect of surface-coupled antigen of liposomes in immunopotentiation. (1987) (23)
Liposomal amphotericin-B in the control of experimental aspergillosis in mice: Part I--Relative therapeutic efficacy of free and liposomal amphotericin-B. (1989) (23)
Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain. (1961) (22)
Purification and properties of ATP-sulphate adenylytransferase from liver (1968) (22)
ENZYMIC STUDIES ON SULPHATIDE METABOLISM IN DIFFERENT STAGES OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (1971) (21)
ENZYMIC DEGRADATION OF URIDINE DIPHOSPHOACETYLGLUCOSAMINE. (1964) (21)
THE NATURE OF SULPHATION OF URONIC ACID‐CONTAINING GLYCOSAMINOGLYCANS CATALYSED BY BRAIN SULPHOTRANSFERASE (1970) (20)
Enzymatic activation of carbon dioxide. I. Crystalline carbon dioxide-activating enzyme. (1958) (19)
Design of liposomes for circumventing the reticuloendothelial cells. (1991) (19)
ISOLATION AND CHARACTERIZATION OF GLYCOSAMINOGLYCANS IN PERIPHERAL NERVE AND SPINAL CORD OF MONKEY (1969) (19)
Recognition of 2-keto-3-deoxyoctonate in bacterial cells and lipopolysaccharides by the sialic acid binding lectin from the horseshoe crab Carcinoscorpius rotunda cauda. (1982) (18)
Urinary excretion of lysosomal arylsulfatases in kwashiorkor. (1967) (18)
Macrophages in host defence--an overview. (1992) (18)
Studies on the formation of active sulphate during connective tissue growth. (1961) (17)
HETEROGENEITY OF ALKALINE PHOSPHATASE IN SHEEP BRAIN * (1966) (17)
ConA-sepharose affinity chromatography: a study on the glycoprotein nature of brain acid hydrolases. (1974) (17)
A new cold agglutinin from Achatina fulica snails. (1984) (17)
Chemistry and Metabolism of Glycosaminoglycans of the Nervous System (1972) (17)
Affinity chromatographic separation of arylsulfatase A and B using Cibacron Blue-Sepharose. (1977) (17)
Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain. (1961) (16)
Lipuscmes as Capriers for Production of Sugar Specific Prepartion of Antibodies Operation of Antigalitosyl Aftisfrum (1982) (16)
Studies on the interaction of concanavalin A with glycoproteins. (1975) (15)
Enhanced intracellular stability and efficacy of PEG modified dextranase in the treatment of a model storage disorder. (1994) (15)
Properties and sub-cellular distribution of two sulfatases which degrade adenosine 5'-phosphosulfate. (1970) (15)
PURIFICATION AND PROPERTIES OF THE CMP‐N‐ACETYLNEURAMINIC ACID SYNTHESIZING ENZYME FROM SHEEP BRAIN * (1964) (15)
Effect of carrageenin and cortisone on the formation of cultivated connective tissue. I. Isolation and characterisation of glycosaminoglycans. (1969) (15)
THE ROLE OF ADENOSINE TRIPHOSPHATE IN THE ENZYMATIC ACTIVATION OF CARBON DIOXIDE1 (1957) (14)
Protein-protein conjugation on a lectin matrix. (1977) (14)
Purification of glucosamine-6-phosphate N-acetylase from sheep brain. (1962) (14)
Mannosylated liposomes as carriers for hamycin in the treatment of experimental aspergillosis in Balb/C mice. (1993) (14)
The effect of surface sugars on liposomes in immunopotentiation. (1984) (13)
Brain glycosaminoglycans and glycosaminoglycan sulphotransferase in Sanfilippo syndrome. (1970) (13)
Role of vitamin A in sulphate metabolism. Studies on the enzymic activation of sulphate by various tissue extracts of normal and vitamin A-deficient rats. (1967) (13)
Liposomes in immunology (1984) (13)
Design of liposomes to improve delivery of amphotericin-B in the treatment of aspergillosis (2004) (12)
Homogeneous enzyme immunoassay of estriol in picogram amounts. (1983) (12)
Studies on the interaction of immobilized lectin from Ricinus communis with a simple sugar and a polysaccharide. (1974) (12)
Effect of elimination of phagocytic cells by liposomal dichloromethylene diphosphonate on aspergillosis virulence and toxicity of liposomal amphotericin B in mice. (1994) (12)
PARTIAL PURIFICATION, PROPERTIES AND GLYCOPROTEIN NATURE OF ARYLSULPHATASE B FROM SHEEP BRAIN (1976) (11)
Liposomal hamycin in the control of experimental aspergillosis in mice: relative toxicity, therapeutic efficacy and tissue distribution of free and liposomal hamycin. (1992) (11)
Liposome immune lysis assay (LILA) for gelonin. (1992) (11)
Plant glycosides in a liposomal drug-delivery system. (1987) (11)
Enhanced intracellular stability of dextran-horse radish peroxidase conjugate: an approach to enzyme replacement therapy. (1992) (11)
The adjuvant effect of liposomes in eliciting anti-galactosyl antibodies. (1982) (10)
Mannosylated Liposome-Mediated Delivery of Amphotericin-B in the Control of Experimental Aspergillosis in BALB/c Mice (1991) (10)
On the specificity of carbohydrate-lectin recognition. The interaction of a lectin from Ricinus communis beans with simple saccharides and concanavalin A. (1974) (10)
A rapid and sensitive assay for detection of nanogram quantities of castor-bean (Ricinus communis) lectins. (1979) (10)
Receptor-mediated uptake of asialoganglioside liposomes: sub-cellular distribution of the liposomal marker in isolated liver cell types. (1985) (10)
Transfer of N-acetylneuraminic acid to neuraminidase-treated alkaline phosphatase from sheep brain. (1970) (10)
Glycosaminoglycans of human urine. I. Protein-polysaccharide linkage region in the non-sulphated glycosaminoglycans of normal urine. (1968) (9)
Hurler's disease: a clinical and biochemical study of a case. (1969) (9)
Targeting of liposomes to hepatocytes. (1991) (8)
Role of vitamin A in sulphate metabolism: 3--Sulphate activation in hypervitaminotic A rats. (1966) (8)
Role of vitamin A in sulphate metabolism. 2. Studies on sulphate incorporation into mucopolysaccharides in hypervitaminotic A rats. (1966) (8)
Age dependent changes in the level of cytidine 5'-monophospho-N-acetyl neuraminic acid synthesizing and degrading enzymes and bound sialic acid in rat liver. (1967) (8)
Fractionation of sialoglycoproteins on an immobilized sialic acid-binding lectin. (1981) (8)
Glucosamine-6-phosphate deaminase activity during connective tissue growth. (1963) (8)
Subcellular distribution, age dependent variation and species differences of brain pyridoxal phosphate phosphatase. (1972) (8)
Purification of brain lysosomal arylsulphatases by Concanavalin A-Sepharose column chromatography. (1973) (8)
STUDIES ON SULPHATE METABOLISM IN EUGLENA GRACILIS. I. UPTAKE & ACTIVATION OF SULPHATE & DEGRADATION OF ACTIVE SULPHATE BY EUGLENA GRACILIS. (1964) (8)
Low sulfatase activities in metachromatic leukodystrophy (MLD). A controlled study of enzymes in 9 living and 4 autopsied patients with MLD. (1964) (8)
Conjugation of proteins and enzymes with hydrophilic polymers and their applications. (1991) (8)
Tissue distribution and antileishmanial activity of liposomised Amphotericin-B in Balb/c mice§ (1991) (7)
Sulphate metabolism in developing rat brain: a study with subcellular fractions. (1971) (7)
Phosphatases from human brain. I. Purification and properties of pyridoxal phosphate phosphatase. (1963) (7)
Monoconjugate enzyme linked immunoassay (1978) (7)
Partial purification and properties of cytidine 5'-monophospho-N-acetyl neuraminic acid degrading enzyme from sheep liver. (1969) (7)
Selective uptake of liposomes by different cell types of liver through the involvement of liposomal surface glycosides. (1981) (6)
Glycosaminoglycans of human urine. 3. Isolation and characterization of urinary glycosaminoglycans in normal and kwashiorkor children. (1970) (6)
Metachromatic leucodystrophy (sulphatide lipidoses). Juvenile type: case report. (1969) (6)
Lectin-binding assay by polyethylene glycol 8000. (1987) (6)
Role of Surface Glycolipids - Natural or Synthetic Origin on the Biodistribution of Liposomes (1992) (6)
Short communications. Enzymic degradation of cytidine 5'-monophosphate N-acetylneuraminic acid. (1967) (6)
Affinity immobilisation and "negative" crosslinking: a probe for tertiary and quaternary protein structure. (1979) (6)
PURIFICATION OF URIDINE DIPHOSPHOGLUCOSE PYROPHOSPHORYLASE FROM HUMAN BRAIN * (1961) (6)
Detection of liposomes in portal blood following oral administration. (1984) (5)
Unique subunit structure for Ricinus communis agglutinin. (1978) (5)
A new haemagglutinin from the amoebocytes of the horseshoe crab Carcinoscorpius rotundicauda. Purification and role in cellular aggregation. (1985) (5)
Circular dichroism studies on carcinoscorpin, the sialic acid binding lectin of horseshoe crab, Carcinoscorpius rotundacauda. (1984) (5)
Studies on enzymic synthesis of cerebroside sulphate from 3'-phosphoadenosine-5'-phosphosulphate. (1965) (5)
Enhanced stability and therapeutic utility of proteins upon conjugation with hydrophilic polymers. (1993) (5)
Monovalent lectin as a novel tool for the resolution of microheterogeneity in glycoproteins. (1980) (5)
Sanfilippo syndrome (mucopolysaccharidosis 3). (1970) (5)
Critical density for protein-protein monoconjugation on a polysaccharide matrix. (1979) (4)
Liposomal amphotericin-B as a therapeutic measure to control experimental aspergillosis in BALB/c mice. (1990) (4)
Dynamics of precipitin reaction: effect of the cholesterol & surface density of ganglioside, GM1, on the rate of reaction between lectin from Ricinus communis & liposome containing GM1. (1981) (4)
Liposomes as carriers for sugar specific antibodies: preparation of antigalactosyl antiserum (1982) (4)
Effect of neonatal thyroidectomy on glycolipid metabolism in developing rat brain. (1972) (3)
Fluorescence studies on the interaction of some ligands with carcinoscorpin, the sialic acid specific lectin, from the horseshoe crab,Carcinoscorpius rotundacauda (1983) (3)
Sanfilippo syndrome (mucopolysaccharidosis-3). (1972) (3)
Liposomal hamycin in the control of experimental aspergillosis in mice: effect of phosphatidic acid with and without cholesterol. (1993) (3)
Partial purification of testicular hyaluronidase using concanavalin A - Sepharose affinity chromatography. (1975) (3)
Polyene antibiotics in the membrane environment. (1991) (3)
Studies on acetocoenzyme A kinase from Euglena gracilis. (1962) (3)
Resolution of microheterogeneity in rat liver acid phosphatase using immobilised sialic acid binding lectin. (1981) (2)
Characterisation of lysosomal membrane from rat liver. (1978) (2)
Role of uridine entrapped in liposomes in galactosamine-induced hepatitis. (1977) (2)
Role of vitamin A in sulphate metabolism. I. Studies on sulphate incorporation into mucopolysaccharides in vitamin A deficient rats. (1965) (2)
Glycosaminoglycans of human urine. II. Sulphted glycosaminoglycans of normal adult urine. (1969) (2)
DISCUSSION PAPER: SOME CONSIDERATIONS ON ALKALINE PHOSPHATASE (1969) (2)
A simple and rapid method for quantification of hapten specific antibodies. (1983) (2)
Globoid leukodystrophy (Krabbe's disease). (1970) (2)
Liposomes as immunological carriers for the preparation of antimannosyl antibodies (1982) (2)
REGIONAL DISTRIBUTION OF FOUR ENZYMES ASSOCIATED WITH THE AMINO SUGAR METABOLISM IN SHEEP BRAIN (1964) (2)
Purification and properties of ATP-sulphate adenylyltransferase from liver. (1968) (2)
Biochemical studies in Sanfilippo syndrome. (1971) (1)
Muscular dystrophy. (1967) (1)
Biosynthesis of cerebroside sulphate in brain. I. Studies on the nature of the endogenous sulphate acceptor from sheep brain. (1972) (1)
Cerebroside sulphate biosynthesis in brain. (1972) (1)
Glycolipid content of human brain in protein-calorie malnutrition. (1972) (1)
Purification, properties & glycoprotein nature of an atypical arylsulphatase A from chicken brain. (1977) (1)
Enzymatic activation of carbon dioxide. II. Role of biotin in the carboxylation of beta-hydroxyisovaleryl coenzyme A. (1958) (1)
Approach to Tissue Targeting of Drugs and Proteins Using Glycolipid Liposomes (1986) (1)
THE ENZYMIC FORMATION OF CEREBROSIDE SULPHATE IN SHEEP BRAIN (1966) (1)
THE IMMUNOSUPPRESSIVE EFFECT OF CONCANAVALIN A IN MONKEYS (1976) (1)
Effect of carrageenin on the incorporation of S-35-sulphate and C14-glucose into cultivated connective tissue mucopolysaccharides. (1964) (0)
A rapid method for quantification & elucidation of the anomeric sugar specificity of lectins: demonstration with the lectins from Bandeiraea simplicifolia & Ricinus communis. (1980) (0)
Letter from Bimal K. Bachhawat to Marshall W. Nirenberg (1984) (0)
Dual role of liposomes as adjuvant and carrier for the production of sugar-specific antibodies (1984) (0)
Uridine diphosphoacetylglucosamine pyrophosphatase activity during connective tissue growth. (1964) (0)
Role of the liposomal surface carbohydrates on the uptake of entrapped enzyme by liver. (1977) (0)
Studies on concanavalin A-immobilized glucose oxidase. (1975) (0)
The Shanti Swarup Bhatnagar medical lecture, 1991. Enhanced stability of hydrophilic polymer conjugated enzymes, both in circulation and intracellularly : an approach to enzyme therapy (1992) (0)
STUDIES ON THE NATURE OF THE ENDOGENOUS SUBSTRATE IN THE BIOSYNTHESIS OF CEREBROSIDE SULPHATE IN BRAIN (1969) (0)
Liposomes as carrier for production of sugar specific antibodies: preparation of antigalactosyl antiserum. (1982) (0)
Immobilization of testicular hyaluronidase using concanavalin A. (1976) (0)
crassa. Because of the importance of peroxides in the production of mutations in microorganisms and as intermediates in the production of mutations by ultraviolet (2005) (0)
DISTRIBUTION OF CMP-N-ACETYL NEURAMINIC ACID SYNTHESIZING ENZYME, & LIPID & NON-LIPID BOUND SIALIC ACID IN VARIOUS REGIONS OF SHEEP BRAIN. (1965) (0)
Degradation of cerebroside sulphate by arylsulphatase A from chicken & sheep brain. (1979) (0)
Lysosomal acid hydrolases in health and disease. (1974) (0)
Role of Isonicotinic acid hydrazide in the inactivation of pyridoxal phosphate. (1960) (0)
Physiology and Pathology of Glycosaminoglycans and Proteoglycans of the Nervous System (1982) (0)
Defective sulfatide synthesis in Krabbe's disease (globoid leukodystrophy). (1968) (0)
Purification and properties of arylsulphatase A from chicken brain. (1972) (0)
ENZYMATIC ACTIVATION OF CARBON DIOXIDE (2003) (0)
Changes in glycolipids in peripheral nerves in leprosy. (1972) (0)
Purification and properties of an aryl sulfatase from human brain (1963) (0)
Purification & properties of aceto CoA kinase from ox brain. (1961) (0)
Induction of granulation tissue in man. (1967) (0)

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