Boris Kholodenko
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Russian biologist
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Molecular Biology
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Biochemistry
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Biology
Boris Kholodenko's Degrees
- PhD Biochemistry Moscow State University
Why Is Boris Kholodenko Influential?
(Suggest an Edit or Addition)According to Wikipedia, Boris Kholodenko is a Russian professor of Systems Biology at Systems Biology Ireland and Conway Institutes at University College Dublin, Ireland. He is also an adjunct professor at Thomas Jefferson University, Philadelphia where his group was behind the development of the first model of Epidermal growth factor receptor.
Boris Kholodenko's Published Works
Published Works
- Cell-signalling dynamics in time and space (2006) (1298)
- Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades (2004) (710)
- Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. (2000) (694)
- Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor* (1999) (641)
- Signalling ballet in space and time (2010) (576)
- Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance. (2012) (416)
- Untangling the wires: A strategy to trace functional interactions in signaling and gene networks (2002) (413)
- The dynamic control of signal transduction networks in cancer cells (2015) (267)
- Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses (2007) (252)
- Systems-level interactions between insulin–EGF networks amplify mitogenic signaling (2009) (242)
- Why cytoplasmic signalling proteins should be recruited to cell membranes. (2000) (237)
- The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier (2010) (237)
- Quantitative analysis of signaling networks. (2004) (229)
- Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics (2010) (226)
- Spatial gradients of cellular phospho‐proteins (1999) (208)
- Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data (2004) (182)
- Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops* (2006) (178)
- Evaluating Strategies to Normalise Biological Replicates of Western Blot Data (2014) (175)
- Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors (2003) (172)
- Computational Approaches for Analyzing Information Flow in Biological Networks (2012) (171)
- When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling (2013) (168)
- Quantification of information transfer via cellular signal transduction pathways (1997) (167)
- Effects of sequestration on signal transduction cascades (2006) (162)
- Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients (2015) (135)
- Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches (2016) (132)
- Modular response analysis of cellular regulatory networks. (2002) (131)
- Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling (2014) (125)
- Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades (2012) (122)
- Bistability from double phosphorylation in signal transduction (2006) (118)
- MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience? (2002) (117)
- Implications of macromolecular crowding for signal transduction and metabolite channeling. (1998) (115)
- Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexity. (2005) (109)
- Frequency modulation of ERK activation dynamics rewires cell fate (2016) (106)
- Frequency modulation of ERK activation dynamics rewires cell fate (2015) (105)
- Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades (2006) (103)
- PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. (2010) (102)
- A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks (2006) (101)
- Metabolic channelling and control of the flux (1993) (99)
- Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. (2011) (98)
- Why do protein kinase cascades have more than one level? (1997) (97)
- Inference of signaling and gene regulatory networks by steady-state perturbation experiments: structure and accuracy. (2005) (94)
- Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation. (2007) (88)
- A dynamic model of the hypoxia-inducible factor 1&agr; (HIF-1&agr;) network (2013) (88)
- Temperature dependence of the epidermal growth factor receptor signaling network can be accounted for by a kinetic model. (2002) (87)
- Four‐dimensional dynamics of MAPK information‐processing systems (2009) (85)
- Diffusion control of protein phosphorylation in signal transduction pathways. (2000) (82)
- Control analysis for autonomously oscillating biochemical networks. (2002) (81)
- Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise (2012) (80)
- A model of O·2-generation in the complex III of the electron transport chain (1998) (79)
- Untangling the signalling wires (2007) (76)
- Spatially distributed cell signalling (2009) (72)
- Complexity of receptor tyrosine kinase signal processing. (2013) (69)
- Control analysis of glycolytic oscillations. (1996) (67)
- MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance. (2016) (67)
- Rac1 and RhoA: Networks, loops and bistability (2018) (61)
- Signalling by protein phosphatases and drug development: a systems‐centred view (2012) (56)
- Signal processing at the Ras circuit: what shapes Ras activation patterns? (2004) (56)
- The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two. (1993) (56)
- Domain-oriented reduction of rule-based network models. (2008) (55)
- The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells. (2016) (54)
- Metabolic engineering in the post genomic era (2004) (53)
- Ca2+ stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria. (1996) (53)
- Control Analysis of Periodic Phenomena in Biological Systems (1997) (52)
- The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility (2014) (52)
- Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2 (2013) (51)
- Positional Information Generated by Spatially Distributed Signaling Cascades (2009) (51)
- Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains. (2006) (49)
- The macroworld versus the microworld of biochemical regulation and control. (1995) (49)
- Feedback regulation in cell signalling: Lessons for cancer therapeutics. (2016) (46)
- Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat heart mitochondria. (1995) (46)
- The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria (1987) (46)
- Integrating network reconstruction with mechanistic modeling to predict cancer therapies (2016) (45)
- Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes. (1998) (45)
- A model of O2.-generation in the complex III of the electron transport chain. (1998) (45)
- Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law. (2002) (43)
- Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling. (2018) (42)
- Performance of objective functions and optimisation procedures for parameter estimation in system biology models (2017) (41)
- Control of the metabolic flux in a system with high enzyme concentrations and moiety-conserved cycles. The sum of the flux control coefficients can drop significantly below unity. (1992) (41)
- Signaling cascades as cellular devices for spatial computations (2009) (40)
- The regulation of glycolysis in human erythrocytes. The dependence of the glycolytic flux on the ATP concentration. (1981) (40)
- The intracellular signaling network as a target for ethanol. (1998) (39)
- Composite control of cell function: metabolic pathways behaving as single control units (1995) (39)
- Getting to the inside of cells using metabolic control analysis. (1994) (37)
- Defining control coefficients in non-ideal metabolic pathways. (1995) (37)
- Endocytosis and signalling: A meeting with mathematics (2009) (37)
- Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System (2011) (37)
- Biothermokinetics of the living cell (1996) (36)
- Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades (2012) (35)
- Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation (2015) (35)
- The topology design principles that determine the spatiotemporal dynamics of G-protein cascades. (2012) (35)
- It takes two to tango--signalling by dimeric Raf kinases. (2013) (35)
- Systems medicine: helping us understand the complexity of disease. (2013) (34)
- ‘Channelled’ pathways can be more sensitive to specific regulatory signals (1993) (34)
- A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network (2015) (34)
- Control analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times. (1995) (33)
- Control analysis of stationary forced oscillations. (1999) (32)
- Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle (2009) (32)
- Giving Space to Cell Signaling (2008) (32)
- How do external parameters control fluxes and concentrations of metabolites? An additional relationship in the theory of metabolic control (1988) (32)
- Integrating Bayesian variable selection with Modular Response Analysis to infer biochemical network topology (2013) (32)
- Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D (2020) (32)
- Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding. (2000) (32)
- Tyr-317 Phosphorylation Increases Shc Structural Rigidity and Reduces Coupling of Domain Motions Remote from the Phosphorylation Site as Revealed by Molecular Dynamics Simulations* (2004) (32)
- Drug Resistance Resulting from Kinase Dimerization Is Rationalized by Thermodynamic Factors Describing Allosteric Inhibitor Effects. (2015) (31)
- Dynamic stability of steady states and static stabilization in unbranched metabolic pathways (1982) (30)
- Control by enzymes, coenzymes and conserved moieties (1994) (29)
- Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration (2020) (29)
- Acute Phase Response as a Biological Mechanism-of-Action of (Nano)particle-Induced Cardiovascular Disease. (2020) (28)
- Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation (2013) (27)
- Control theory of one enzyme. (1994) (27)
- The APC network regulates the removal of mutated cells from colonic crypts. (2014) (27)
- Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated. (1996) (26)
- Multistrip Western blotting to increase quantitative data output (2007) (25)
- A model of O·2- generation in the complex III of the electron transport chain (2004) (25)
- Signalling over a distance: gradient patterns and phosphorylation waves within single cells. (2010) (25)
- Molecular dynamics simulations reveal that Tyr-317 phosphorylation reduces Shc binding affinity for phosphotyrosyl residues of epidermal growth factor receptor. (2009) (25)
- Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies (2014) (24)
- Control theory of metabolic channelling (1994) (24)
- HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status (2016) (24)
- Determination of Functional Network Structure from Local Parameter Dependence Data (2002) (24)
- Kinetic Modeling of Energy Metabolism and Superoxide Generation in Hepatocyte Mitochondria (2001) (24)
- Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses (2014) (23)
- Control analysis of metabolic systems involving quasi-equilibrium reactions. (1998) (23)
- Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device (2015) (22)
- Network-based identification of feedback modules that control RhoA activity and cell migration. (2015) (22)
- Quantitative Biology: Theory, Computational Methods, and Models (2018) (21)
- [Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria]. (2001) (21)
- Cellular information transfer regarded from a stoichiometry and control analysis perspective. (2000) (21)
- Systems biology‐embedded target validation: improving efficacy in drug discovery (2014) (21)
- Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate (2015) (20)
- Molecular control analysis: control within proteins and molecular processes. (1996) (20)
- CONTROL THEORY OF GROUP TRANSFER PATHWAYS (1995) (20)
- DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks (2015) (20)
- Thermodynamics of complexity. The live cell (1998) (19)
- Control of mitochondrial oxidative phosphorylation. (1984) (19)
- Engineering a living cell to desired metabolite concentrations and fluxes: pathways with multifunctional enzymes. (2000) (18)
- Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses. (2015) (18)
- Mechanistic and modular approaches to modeling and inference of cellular regulatory networks (2005) (17)
- Subtleties in control by metabolic channelling and enzyme organization (1998) (16)
- Silence on the relevant literature and errors in implementation (2015) (16)
- Reconstructing static and dynamic models of signaling pathways using Modular Response Analysis (2018) (16)
- How to determine control of growth rate in a chemostat. Using metabolic control analysis to resolve the paradox. (1994) (16)
- Dramatic changes in control properties that accompany channelling and metabolite sequestration (1993) (16)
- The function of ATP/ADP translocator in the regulation of mitochondrial respiration during development of heart ischemic injury. (1993) (15)
- Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction (2007) (15)
- Control in channelled pathways. A matrix method calculating the enzyme control coefficients. (1995) (15)
- Rate limitation within a single enzyme is directly related to enzyme intermediate levels (1994) (14)
- SARAH Domain-Mediated MST2-RASSF Dimeric Interactions (2016) (14)
- A dynamic model of the hypoxia -‐ inducible factor 1 -‐ alpha ( HIF -‐ 1 α ) network (14)
- Control of the G-protein cascade dynamics by GDP dissociation inhibitors. (2013) (14)
- Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control? (1996) (13)
- PI 3 K / Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI 3 K-mutant T 47 D breast cancer cells (13)
- Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy (2016) (13)
- Mammalian protein expression noise: scaling principles and the implications for knockdown experiments. (2012) (13)
- New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling. (2019) (13)
- Versatility of Cooperative Transcriptional Activation: A Thermodynamical Modeling Analysis for Greater-Than-Additive and Less-Than-Additive Effects (2012) (13)
- MST2-RASSF protein-protein interactions through SARAH domains (2016) (13)
- Ca 2 + stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria (1996) (13)
- Control by enzymes, coenzymes and conserved moieties. A generalisation of the connectivity theorem of metabolic control analysis. (1994) (12)
- Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation (2015) (12)
- Control of cell state transitions (2022) (11)
- Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity (2015) (11)
- Signalling mechanisms regulating phenotypic changes in breast cancer cells (2015) (11)
- Inhaled multi-walled carbon nanotubes differently modulate global gene and protein expression in rat lungs (2020) (10)
- Occurrence of paradoxical or sustained control by an enzyme when overexpressed: necessary conditions and experimental evidence with regard to hepatic glucokinase. (2001) (10)
- Quantifying gene network connectivity in silico: scalability and accuracy of a modular approach. (2006) (10)
- Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction (2018) (10)
- Control Analysis of Cellular Signal Transduction Pathways (1998) (10)
- Strong control on the transit time in metabolic channelling (1996) (10)
- G Protein–Coupled Receptor Signaling Networks from a Systems Perspective (2015) (10)
- Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor (2018) (9)
- Molecular biology for flux control. (1995) (9)
- Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding (2000) (8)
- Transcriptionally inducible Pleckstrin homology-like domain, family A, member 1, attenuates ErbB receptor activity by inhibiting receptor oligomerization (2017) (8)
- A systematic analysis of signaling reactivation and drug resistance (2020) (8)
- Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration (2014) (8)
- Catching transcriptional regulation by thermostatistical modeling (2012) (8)
- Steady-State Characterization of Systems with Moiety-Conservations Made Easy: Matrix Equations of Metabolic Control Analysis and Biochemical System Theory (1996) (8)
- Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis (2021) (8)
- An integrative computational approach for a prioritization of key transcription regulators associated with nanomaterial-induced toxicity. (2019) (8)
- [The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria]. (1988) (8)
- Elusive control (1995) (7)
- Bimodal Protein Distributions in Heterogeneous Oscillating Systems (2012) (7)
- Live control of the living cell. (1999) (7)
- Ubiquitin chain specific auto‐ubiquitination triggers sustained oscillation, bistable switches and excitable firing (2014) (7)
- Modular Interaction Strengths in Regulatory Networks; An Example (2004) (7)
- An integrated Bayesian framework for identifying phosphorylation networks in stimulated cells. (2012) (7)
- Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols. (2017) (7)
- HER 2-HER 3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER 2 IHC status (2016) (7)
- How to reveal various aspects of regulation in group-transfer pathways (1995) (7)
- VI-1 CONTROL THEORY OF METABOLIC CHANNELLING (1994) (6)
- The role of long‐chain acyl‐CoA in the damage of oxidative phosphorylation in heart mitochondria (1989) (6)
- Correction to A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network [J. Cell Sci. 126, (2014) 1454-1463] (2015) (6)
- Regulation of glycolysis in human erythrocytes. The mechanism of ATP concentration stabilization. (1981) (5)
- Mapping connections in signaling networks with ambiguous modularity (2019) (5)
- Metabolic Control From The Back Benches: Biochemistry Towards Biocomplexity (2000) (5)
- Protein networks (2002) (5)
- Quantitative analysis ofsignaling networks (2004) (5)
- Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas (2020) (5)
- [Quantitative model of human erythrocyte glycolysis. I. Relationship between the stationary rate of glycolysis and the ATP concentration]. (1977) (4)
- Can Systems Biology Advance Clinical Precision Oncology? (2021) (4)
- Formation of intracellular concentration landscapes by multisite protein modification. (2010) (4)
- HIERARCHIES IN CONTROL (1995) (4)
- [Control of molecular transformations in polyenzyme systems: quantitative theory of the regulation of metabolism]. (1988) (4)
- Spatio-temporal dynamics of protein modification cascades. (2008) (4)
- Sum of the flux control coefficients: What is it equal to in different systems? (1993) (4)
- A new millenium: functional genomics, cellular bioinformatics, regulation analysis. (2000) (3)
- Coenzyme cycles and metabolic control analysis: the determination of the elasticity coefficients from the generalised connectivity theorem. (1995) (3)
- Domain-oriented and modular approaches to the reduction of mathematical models of signaling networks (2005) (3)
- Control and regulation of channelled versus ideal pathways (1996) (3)
- The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks. (2005) (2)
- Direct Transfer of Control and Multidrug Resistance (1996) (2)
- On the personalised modelling of cancer signalling (2016) (2)
- Enzyme IICBGlc of the phosphoenolpyruvate: glucose phosphotransferase system controls the growth rate of Escherichia coli at fixed, low glucose concentrations as determined using glucose-limited chemostats (1996) (2)
- The metabolic control theory of biochemical ocsillating systems. 1. Definitions of the quantitative character (1996) (2)
- [Dynamic stability of a metabolic pathway with single-loop feedback]. (1981) (2)
- [Correlation of impulse currents for a neuron model with multiple inputs]. (1972) (2)
- Hierarchical Control of Electron-Transfer (1998) (2)
- Modeling the Nonlinear Dynamics of Intracellular Signaling Networks (2021) (1)
- Dynamic aspects of cascade-type metabolic regulation (1995) (1)
- 228 Her2–3 heterodimer is a new and better than HER2 IHC score for clinical outcome prognosis (2014) (1)
- Control of Respiration in Heart Mitochondria: Comparative Study of Oxidation of Succinate and NAD-Dependent Substrates (1993) (1)
- Integrating network reconstruction with mechanistic modelling to predict potential cancer therapy (1)
- [Power-law approximation and similarity properties of metabolic regulatory characteristics]. (1983) (1)
- Individualization and optimization of dosings of pharmacological preparations; principle of maximum in the analysis of pharmacological response (1980) (1)
- [Quantitative model of human erythrocyte glycolysis. Region of cell viability determined by ATP concentration]. (1979) (1)
- Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing. (2020) (1)
- [The mitochondrial carrier of adenylates controls ATP production in the physiological range of respiration rates]. (1984) (1)
- Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space (2007) (1)
- Author response: Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration (2020) (1)
- [Nets of excitable elements. VII. Stabilization of the excitation level by inhibiting bonds]. (1974) (1)
- Nonlinear control and self-organization (1995) (1)
- Transcriptional regulatory mechanisms of fibrosis development in mouse lung tissue exposed to carbon nanotubes (2018) (1)
- Four-Dimensional Organization of Cellular Signal Transduction Cascades (2001) (1)
- [Regulation of erythrocyte energy metabolism. Dependence of glycolysis characteristics on donor individual parameters]. (1981) (1)
- [Regulation of the heart mitochondrial respiration rate. Comparison of oxidation of succinate and NAD-dependent substrates]. (1991) (1)
- [Dynamic stability and parametric stabilization of steady states of unbranched metabolic pathways]. (1981) (1)
- Control theory of metabolic channelling (2005) (1)
- Metabolic engineering, what it was and what it is. (2004) (1)
- BTK traditions and perspectives: Complex biothermokinetics and control analysis. (1998) (1)
- The macroworld venus the microworld of bioch ical regulation and control (1995) (1)
- Title Endocytosis and signalling : A meeting with mathematics (2016) (0)
- Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages (2023) (0)
- A dynamic model of the MYCN regulated DNA damage response in Neuroblastoma (2014) (0)
- Control of Dynamics and Steady State: Applications to Multidrug Resistance (1996) (0)
- Abstract CN05-03: Personalized cancer diagnostics and therapeutics based on the computational modeling of signal transduction networks (2015) (0)
- Metabolic control theory of biochemical oscillating systems. 2. Calculation of the periodic control coefficients (1996) (0)
- UvA-DARE ( Digital Academic Repository ) Control analysis of glycolytic oscillations (2017) (0)
- CONTROL OF THE RESPIRATION RATE IN HEART MITOCHONDRIA. COMPARISON OF THE OXIDATION OF SUCCINATE AND NAD-DEPENDENT SUBSTRATES (1991) (0)
- [Role of the 2,3-diphosphoglycerate shunt in regulating energy metabolism in human erythrocytes]. (1985) (0)
- Modular and Mechanistic Analyses of Cellular Networks : Can We Navigate Through Molecular Jungles ? (2003) (0)
- Details of the Bayesian formalisms (2013) (0)
- Reengineering protein-phosphorylation switches (2021) (0)
- Title Toggle switches , pulses and oscillations are intrinsic propertiesof the Src activation / deactivation cycle (2017) (0)
- Control theory of cell metabolism: towards more realistic "non-ideal" systems. (1995) (0)
- 11 From benchside to byteside: what we can learn from computational modelling (2010) (0)
- Performance of objective functions and optimisation procedures for parameter estimation in system biology models (2017) (0)
- Theoretical model of the full-length human p52 Shc adaptor protein obtained by homology modeling and 2 ns Molecular Dynamics simulations (2005) (0)
- A dynamic model of the hypoxia‐inducible factor (HIF) network (2013) (0)
- Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure (2008) (0)
- 1P295 Computational analysis of protein-protein interactions(Bioinformatics:Structural genomics,The 48th Annual Meeting of the Biophysical Society of Japan) (2010) (0)
- [Theory of metabolism regulation: a complete system of equations for regulation coefficients]. (1989) (0)
- Edinburgh Research Explorer Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D in (2020) (0)
- [Biochemical individuality of humans and invariants of regulation. Scale invariance of the characteristic of glycolysis in erythrocytes]. (1980) (0)
- Three-factor models versus time series models: quantifying time-dependencies of interactions between stimuli in cell biology and psychobiology for short longitudinal data. (2016) (0)
- On the personalised modelling of cancer signalling (cid:31) On the personalised modelling of cancer signalling (cid:31) On the personalised modelling of cancer signalling (cid:31) On the personalised modelling of cancer signalling (cid:31) (2017) (0)
- Metabolic engineering in the post genomic era: what it should become. (2004) (0)
- Metabolic design: Engineering a living cell to desired metabolite concentrations and fluxes. (1998) (0)
- Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction (2018) (0)
- [Control of the rate of the glucokinase reaction by its elementary stages]. (1996) (0)
- 1 Spatially Distributed Cell Signalling (2017) (0)
- [Optical tactics of antibacterial therapy for the trigger model of the infection process]. (1982) (0)
- How Combining Structurally Different RAF Inhibitors Can Open New Strides In Targeted Melanoma Therapy (2018) (0)
- Eph Receptor Signaling and Ephrins (2013) (0)
- Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate (2015) (0)
- Title Positional Information Generated by Spatially DistributedSignaling Cascades Author ( s ) (2017) (0)
- Running title : A framework for pathway inference and modelling Character count : 48856 (2017) (0)
- [Stabilization of the relative concentration of ATP and invariants in the regulation of erythrocyte energy metabolism]. (1980) (0)
- When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling (2013) (0)
- THE RATE OF THE GLUCOKINASE REACTION IS CONTROLLED BY ITS ELEMENTAL STEPS (1996) (0)
- Mapping connections in signaling networks with ambiguous modularity (2019) (0)
- MODIFICATION OF THE SUMMATION EQUATIONS OF METABOLIC CONTROL THEORY : THE CASE FOR ENZYME CONCENTRATIONS COMPARABLE WITH SUBSTRATE CONCENTRATIONS (1992) (0)
- Multiplicity of Control (1993) (0)
- Modeling the ErbB Signaling Network in MCF-7 Breast Cancer Cells and Analysis of Ligand-Dependent Responses (2006) (0)
- [The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium]. (1989) (0)
- Title Molecular Dynamics Simulations Reveal that Tyr-317 Phosphorylation Reduces Shc Binding Affinity for Phosphotyrosyl Residues of Epidermal Growth Factor Receptor (2017) (0)
- The ERBB pathway that regulates the G 1 / S transition (2012) (0)
- [Nets of excitable elements. IV. Nets of elements without refractoriness in continuous time]. (1974) (0)
- Protein-protein interactions, metabolite channelling, and the control flux (1996) (0)
- COUPLING BETWEEN H+ AND/OR NA+ TRANSLOCATION AND ATP SYNTHESIS/HYDROLYSIS BY F0F1-ATPASZES : CAN THE SAME ENZYME UTILIZE BOTH DELTA MU H+ AND DELTA MU NIA+ AND CAN A CELL WITH SUCH A PROTEIN SURVIVE ? (1992) (0)
- Signalling ballet in four dimensions Supplementary Information (0)
- Control and absence thereof in steady periodic phenomena (1996) (0)
- Control analysis oftransit time forfree andenzyme-bound metabolites: physiological andevolutionary significance ofmetabolic responsetimes (1995) (0)
- 533: Proteomic profiling of N-Myc-associated proteins in neuroblastoma (2014) (0)
- Bifurcation Analysis on MAPK Cascade System (2008) (0)
- [Study of the dynamic behavior of the glycolytic system using the simplest model]. (1979) (0)
- Modified Poly ( L-Lactic Acid ) Scaffolds Using Flow Perfusion (2007) (0)
- The bug in the machine. Control analysis at constant input flux rather that at constant substrate concentration (1997) (0)
- [A new theorem in the theory of metabolism regulation: how external parameters control the flow and concentration of metabolites]. (1988) (0)
- Ultrasensitivity, Bistability, and Oscillations in Signal Transduction (2007) (0)
- Understanding Cell Fate Decisions by Identifying Crucial System Dynamics (2012) (0)
- Signalling ballet in four dimensions (2017) (0)
- [Quantitative model of human erythrocyte glycolysis. Relationship between erythrocyte energy metabolism and Na+, K+-ATPase activity]. (1979) (0)
- Relationship Between Dimensionality and Convergence of Optimization Algorithms: A Comparison Between Data-Driven Normalization and Scaling Factor-Based Methods Using PEPSSBI. (2021) (0)
- [Degree of stability of metabolic chain with 1 feedback loop]. (1987) (0)
- [Nets of excitable elements. 3. Ring-type nets]. (1973) (0)
- How do mitochondrial enzymes control the respiration and superoxide production rates (1998) (0)
- Title PI 3 K / Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI 3 K-mutant T 47 D breast cancer cells (2017) (0)
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