Bradley Hyman

Q: What Schools Are Affiliated With Bradley Hyman

Bradley Hyman is affiliated with the following schools: Harvard University, Bar-Ilan University, University of California, Berkeley, University of Minnesota, University of Melbourne, Northwestern University, Stanford University, Purdue University, University of Iowa, University of Washington, Massachusetts General Hospital

Bradley Hyman's AcademicInfluence.com Rankings

Bradley Hyman

Biology

#1736

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#2822

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Neuroscience

#145

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#153

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Bradley Hyman

Philosophy

#1921

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#3380

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#360

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#702

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Biology
Philosophy

Bradley Hyman's Degrees

Doctorate Medicine Stanford University

Why Is Bradley Hyman Influential?

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According to Wikipedia, Bradley Theodore Hyman is currently John B. Penney, Jr. Professor of Neurology at Harvard Medical School and Director of the Massachusetts Alzheimer Disease Research Center and Memory Disorder Unit at Massachusetts General Hospital. He was educated at Northwestern University and the University of Iowa . He was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 2001 and the Potamkin Prize in 2006, together with Karen Duff and Karen Ashe.

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Bradley Hyman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease (2011) (12716)
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest (2006) (9145)
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis (1997) (3245)
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease (1992) (2472)
Neuropathological alterations in Alzheimer disease. (2011) (2397)
National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (2012) (2093)
National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2011) (1839)
Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation (2003) (1702)
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease (1996) (1676)
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease (2011) (1656)
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) (1494)
Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease (1997) (1458)
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. (1984) (1403)
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease (1997) (1388)
Analysis of shared heritability in common disorders of the brain (2016) (1385)
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function (2005) (1366)
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. (1991) (1343)
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions (1993) (1125)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (1073)
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease (2012) (1040)
Primary age-related tauopathy (PART): a common pathology associated with human aging (2014) (988)
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice (1999) (960)
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease (2008) (957)
Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia (2009) (898)
Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease (2007) (881)
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals (2008) (877)
The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease (2014) (801)
Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques (2009) (756)
The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide (2010) (752)
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta (2013) (742)
Tau positron emission tomographic imaging in aging and early Alzheimer disease (2016) (737)
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. (2002) (708)
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (2017) (693)
APPSW Transgenic Mice Develop Age‐related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1 (1997) (689)
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. (2000) (672)
Perforant pathway changes and the memory impairment of Alzheimer's disease (1986) (671)
Alpha-2 macroglobulin is genetically associated with Alzheimer disease (1998) (665)
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease (2000) (661)
Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain (2004) (635)
Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease (1992) (620)
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model (2007) (617)
Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice (2009) (614)
Microglial response to amyloid plaques in APPsw transgenic mice. (1998) (610)
Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? (1993) (608)
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease (2014) (604)
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. (2005) (590)
Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells (1996) (580)
Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family (1998) (568)
Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue (2015) (553)
Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy (2005) (551)
Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' (1998) (548)
Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse (1997) (547)
Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks (2008) (546)
MRI measures of entorhinal cortex vs hippocampus in preclinical AD (2002) (536)
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. (1998) (526)
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. (2007) (526)
Tau protein liquid–liquid phase separation can initiate tau aggregation (2018) (523)
Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. (1991) (512)
Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria (2004) (505)
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation (1995) (499)
Caspase activation precedes and leads to tangles (2010) (490)
Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy (2001) (486)
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup (2011) (485)
Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy (1995) (464)
Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease (2002) (440)
Memory‐related neural systems in Alzheimer's disease (1990) (440)
Entorhinal cortex pathology in Alzheimer's disease (1991) (437)
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide (2001) (433)
Hsp70 Reduces α-Synuclein Aggregation and Toxicity* (2004) (425)
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo (2007) (420)
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer's Association workgroup (2011) (410)
H. M.’s Medial Temporal Lobe Lesion: Findings from Magnetic Resonance Imaging (1997) (410)
Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinson's Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity (1998) (399)
At the interface of sensory and motor dysfunctions and Alzheimer's disease (2015) (389)
The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers (2011) (385)
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. (2006) (382)
Formation of Toxic Oligomeric α-Synuclein Species in Living Cells (2008) (380)
Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid (1993) (375)
The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. (2012) (369)
Dysferlin Interacts with Annexins A1 and A2 and Mediates Sarcolemmal Wound-healing* (2003) (369)
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019) (366)
Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy‐X04, a Systemically Administered Congo Red Derivative (2002) (364)
The Alzheimer's Disease-Associated Amyloid $\beta$-Protein Is an Antimicrobial Peptide (2010) (358)
Synergy between amyloid-β and tau in Alzheimer’s disease (2020) (350)
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. (2007) (349)
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. (2011) (348)
Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation (2010) (336)
TorsinA and heat shock proteins act as molecular chaperones: suppression of α‐synuclein aggregation (2002) (331)
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. (2002) (330)
Human LilrB2 Is a β-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s Model (2013) (330)
Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease (1996) (329)
Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-β In Vivo by Immunotherapy (2002) (328)
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. (2002) (325)
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model (2000) (324)
The Co-chaperone Carboxyl Terminus of Hsp70-interacting Protein (CHIP) Mediates α-Synuclein Degradation Decisions between Proteasomal and Lysosomal Pathways* (2005) (322)
Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein (1995) (321)
Distinct Roles In Vivo for the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-Synuclein (2011) (318)
Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor Malonate (1993) (313)
Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma* (1996) (312)
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation (2002) (311)
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis (2012) (308)
Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine. (1996) (303)
Neuronal expression of myeloperoxidase is increased in Alzheimer's disease (2004) (302)
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor (1993) (301)
Tau pathophysiology in neurodegeneration: a tangled issue (2009) (300)
Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity (2011) (299)
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias (2014) (295)
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. (1999) (290)
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes (2003) (288)
Beta-secretase activity increases with aging in human, monkey, and mouse brain. (2004) (286)
Alzheimer disease (2021) (284)
Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults (2011) (283)
Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. (2013) (283)
Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy (2003) (282)
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. (1997) (281)
The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimer's Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution (1993) (278)
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score (2017) (277)
The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate* (2005) (276)
In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. (2005) (274)
Meta‐analysis of Parkinson's Disease: Identification of a novel locus, RIT2 (2012) (274)
Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease (2011) (274)
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. (2006) (267)
Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. (2012) (260)
Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology (2012) (255)
Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease. (1999) (255)
Alzheimer's disease: synapses gone cold (2011) (254)
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain (2015) (254)
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice (2003) (253)
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity. (2004) (253)
Immunohistochemical Study of the β-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer's Disease Brains (1998) (250)
Age but Not Diagnosis Is the Main Predictor of Plasma Amyloid β-Protein Levels (2003) (247)
Feature article: are neurons lost from the primate cerebral cortex during normal aging? (1998) (247)
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. (2000) (245)
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations. (2000) (245)
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease (2000) (241)
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. (1995) (240)
α-Synuclein–enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons (2001) (234)
Family-based association between Alzheimer's disease and variants in UBQLN1. (2005) (233)
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. (2000) (232)
γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease (2009) (230)
Dopamine D1 Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking (2006) (226)
Notch1 inhibits neurite outgrowth in postmitotic primary neurons (1999) (224)
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease (2002) (224)
Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone (1987) (224)
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo (2018) (221)
Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. (2011) (219)
Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase (2017) (217)
LRP1 is a master regulator of tau uptake and spread (2020) (217)
Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid β Peptide (2012) (217)
Characterization of the Precursor Protein of the Non-Aβ Component of Senile Plaques (NACP) in the Human Central Nervous System (1996) (217)
Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease. (1999) (216)
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease (2020) (216)
Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging (2011) (215)
Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease (2017) (214)
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. (2009) (213)
Growth Arrest of Individual Senile Plaques in a Model of Alzheimer's Disease Observed by In Vivo Multiphoton Microscopy (2001) (209)
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain (2006) (209)
Apolipoprotein E ε4 Is Associated With the Presence and Earlier Onset of Hemorrhage in Cerebral Amyloid Angiopathy (1996) (208)
Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease. (1990) (207)
Apolipoprotein E and cognitive change in an elderly population (1996) (206)
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation (2015) (206)
Neuropsychological correlates of bilateral amygdala damage. (1990) (206)
Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation (2004) (205)
APOE and Alzheimer’s Disease: Advances in Genetics, Pathophysiology, and Therapeutic Approaches. (2021) (205)
The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. (2000) (203)
Development of the Superior Temporal Neocortex Is Anomalous in Trisomy 21 (1994) (203)
Mechanisms of protein seeding in neurodegenerative diseases. (2013) (202)
Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth (2009) (201)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2 (1998) (200)
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. (1992) (200)
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease (2020) (200)
Propagation of Tau Pathology in a Model of Early Alzheimer’s Disease (2012) (199)
Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). (1995) (199)
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's (2016) (196)
Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis (2019) (196)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2019) (194)
Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice (1997) (191)
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease (2018) (188)
Progression of Cerebral Amyloid Angiopathy: Accumulation of Amyloid-ß40 in Affected Vessels (1998) (188)
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. (2005) (185)
Amyloid-dependent and amyloid-independent stages of Alzheimer disease. (2011) (185)
Motor dysfunction and gliosis with preserved dopaminergic markers in human α-synuclein A30P transgenic mice (2003) (185)
Cortical Synaptic Integration In Vivo Is Disrupted by Amyloid-β Plaques (2004) (184)
Brain Expression of Apolipoproteins E, J, and A‐I in Alzheimer's Disease (1996) (184)
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. (2007) (183)
Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease (1992) (181)
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease. (1994) (178)
Soluble forms of tau are toxic in Alzheimer’s disease (2012) (178)
Endocytic receptor LRP together with tPA and PAI‐1 coordinates Mac‐1‐dependent macrophage migration (2006) (175)
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease (2015) (175)
Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease (2018) (175)
1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism (1992) (174)
Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects Without Alzheimer Disease (2008) (174)
Dopaminergic neuron loss and up‐regulation of chaperone protein mRNA induced by targeted over‐expression of alpha‐synuclein in mouse substantia nigra (2007) (174)
Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies (2017) (173)
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. (2007) (173)
BACE Is Degraded via the Lysosomal Pathway* (2005) (171)
Expression of APP pathway mRNAs and proteins in Alzheimer’s disease (2007) (170)
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor Published, JLR Papers in Press, May 1, 2005. DOI 10.1194/jlr.M500114-JLR200 (2005) (170)
Transgenic models of Alzheimer’s disease: Learning from animals (2005) (170)
Small Heat Shock Proteins Protect Against α-Synuclein-Induced Toxicity and Aggregation (2006) (169)
Amyloid-β Antibody Treatment Leads to Rapid Normalization of Plaque-Induced Neuritic Alterations (2003) (168)
Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease (1996) (167)
In Vivo Imaging of Reactive Oxygen Species Specifically Associated with Thioflavine S-Positive Amyloid Plaques by Multiphoton Microscopy (2003) (166)
Role of the β-Chemokine Receptors CCR3 and CCR5 in Human Immunodeficiency Virus Type 1 Infection of Monocytes and Microglia (1998) (165)
Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment (2009) (165)
Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. (2007) (164)
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes (2016) (163)
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. (2006) (162)
Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and β-Secretase β-Site APP-Cleaving Enzyme (2006) (160)
Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain (2018) (159)
Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo (2013) (158)
Warfarin-related purple toes syndrome and cholesterol microembolization. (1987) (157)
Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. (1996) (157)
γ‐Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila (2003) (156)
Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. (2013) (156)
Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids (1991) (154)
Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro (2004) (154)
α-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining (2000) (153)
Association of homocysteine with plasma amyloid β protein in aging and neurodegenerative disease (2005) (152)
Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice (2008) (152)
Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein (2005) (151)
Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease. (2014) (151)
Progressive aphasia in a patient with Pick's disease (1990) (151)
Enhanced Tau Aggregation in the Presence of Amyloid β. (2017) (151)
Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. (2003) (150)
Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease (1998) (150)
Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease (2012) (149)
CHIP Targets Toxic α-Synuclein Oligomers for Degradation* (2008) (149)
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease (2018) (148)
Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent α-Synuclein Oligomer Formation and Rescue α-Synuclein-Induced Toxicity (2010) (146)
Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. (2010) (146)
Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels. (2003) (145)
α-Synuclein Strains Target Distinct Brain Regions and Cell Types (2019) (144)
Kunitz Protease Inhibitor‐Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease (1992) (143)
Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype. (1995) (142)
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain (2013) (142)
Demonstration by Fluorescence Resonance Energy Transfer of Two Sites of Interaction between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein: Role of the Intracellular Adapter Protein Fe65 (2001) (141)
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. (2014) (140)
The γ Secretase-generated Carboxyl-terminal Domain of the Amyloid Precursor Protein Induces Apoptosis via Tip60 in H4 Cells* (2002) (140)
Differential effect of three‐repeat and four‐repeat tau on mitochondrial axonal transport (2009) (138)
Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease. (1997) (138)
Autoantibodies to amyloid‐β and Alzheimer's disease (2001) (137)
Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients (2017) (137)
In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons (2008) (137)
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. (1998) (136)
Rapid Progression from Mild Cognitive Impairment to Alzheimer’s Disease in Subjects with Elevated Levels of Tau in Cerebrospinal Fluid and the APOE ε4/ε4 Genotype (2009) (133)
Pathological alterations in the amygdala in Alzheimer's disease (1990) (133)
The Neuropathological Diagnosis of Alzheimer’s Disease: Clinical-Pathological Studies (1997) (132)
Fas Receptor and Neuronal Cell Death after Spinal Cord Ischemia (2000) (132)
PART, a distinct tauopathy, different from classical sporadic Alzheimer disease (2015) (131)
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. (1993) (131)
A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. (2013) (130)
The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity* (2009) (129)
α2‐Macroglobulin Enhances the Clearance of Endogenous Soluble β‐Amyloid Peptide via Low‐Density Lipoprotein Receptor‐Related Protein in Cortical Neuron (1999) (129)
Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy. (2001) (129)
Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. (2000) (129)
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia. (2008) (125)
Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease (2015) (124)
Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts (2017) (122)
Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development. (1994) (122)
The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease (2007) (122)
Alpha-synuclein aggregation involves a bafilomycin A1-sensitive autophagy pathway (2012) (122)
Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5) (2011) (122)
Cerebrospinal fluid levels of amyloid β‐protein in alzheimer's disease: Inverse correlation with severity of dementia and effect of apolipoprotein e genotype (1995) (122)
Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury. (1999) (121)
Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism (1991) (121)
Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling (2000) (120)
The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors. (1999) (120)
Confirmation of an association between a polymorphism in exon 3 of the low‐density lipoprotein receptor‐related protein gene and Alzheimer's disease (1998) (120)
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms (2005) (119)
Retinal blood flow in mild cognitive impairment and Alzheimer's disease (2015) (119)
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. (2016) (118)
Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta‐analysis (2009) (118)
Familial and sporadic Alzheimer's disease (1996) (117)
Expression of the Very Low‐Density Lipoprotein Receptor (VLDL‐r), an Apolipoprotein‐E Receptor, in the Central Nervous System and in Alzheimer's Disease (1996) (116)
Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease (1994) (115)
Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies (1999) (115)
The Intracellular Domain of the Low Density Lipoprotein Receptor-related Protein Modulates Transactivation Mediated by Amyloid Precursor Protein and Fe65* (2003) (114)
Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. (1996) (113)
A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. (2001) (110)
&agr;-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease (2009) (110)
Amyloid‐β associated volume loss occurs only in the presence of phospho‐tau (2011) (110)
Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells (2008) (110)
Functional Alterations in Alzheimer's Disease: Selective Loss of Mitochondrial-encoded Cytochrome Oxidase mRNA in the Hippocampal Formation (1994) (110)
Structural Magnetic Resonance Imaging in Established and Prodromal Alzheimer Disease: A Review (2003) (109)
Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. (2004) (109)
Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome (2000) (109)
Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: A stereological estimate of neuronal loss (1993) (108)
Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis (2014) (108)
Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy. (1998) (108)
Aggregation and disaggregation of senile plaques in Alzheimer disease. (1997) (108)
Demonstration of BACE (β-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy (2004) (107)
Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain (2017) (106)
Designed helical peptides inhibit an intramembrane protease. (2003) (106)
Brain Oligomeric &bgr;-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice (2011) (106)
Are Tangles as Toxic as They Look? (2011) (106)
APOEε2 is associated with milder clinical and pathological Alzheimer disease (2015) (106)
Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. (2015) (106)
Alzheimer's mutation (1991) (105)
Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease (2014) (105)
Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging (2003) (105)
High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types (2014) (104)
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro. (2004) (103)
Functional Alterations in Alzheimer's Disease: Diminution of Cytochrome Oxidase in the Hippocampal Formation (1993) (102)
Plasma Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men (2008) (101)
Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease. (2000) (101)
Oxidative stress and lipid peroxidation are upstream of amyloid pathology (2015) (101)
Apolipoprotein E Receptors Mediate Neurite Outgrowth through Activation of p44/42 Mitogen-activated Protein Kinase in Primary Neurons* (2004) (100)
Studying synapses in human brain with array tomography and electron microscopy (2013) (99)
Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APPV717F transgenic mice (2000) (98)
Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study. (2008) (98)
Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias. (2000) (98)
Synaptic alterations in the rTg4510 mouse model of tauopathy (2013) (97)
The membrane organization of leukotriene synthesis. (2004) (97)
Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly (2016) (97)
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity (2015) (97)
Quantitation of apoE Domains in Alzheimer Disease Brain Suggests a Role for apoE in Aß Aggregation (2001) (97)
CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease (2018) (96)
Functional Alterations in Alzheimer's Disease: Decreased Glucose Transporter 3 Immunoreactivity in the Perforant Pathway Terminal Zone (1995) (96)
Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice (2002) (96)
Imaging Amyloid-β Deposits In Vivo (2002) (96)
Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study (2008) (96)
Predicting the location of entorhinal cortex from MRI (2009) (95)
Inhibition of amyloid-β plaque formation by α-synuclein (2015) (95)
Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. (2013) (95)
Adult Onset Leukodystrophy with Neuroaxonal Spheroids: Clinical, Neuroimaging and Neuropathologic Observations (2009) (95)
Apolipoprotein E modulates γ‐secretase cleavage of the amyloid precursor protein (2004) (95)
The nuclear membrane organization of leukotriene synthesis (2008) (95)
Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations. (2004) (94)
Plaque-Derived Oxidative Stress Mediates Distorted Neurite Trajectories in the Alzheimer Mouse Model (2006) (94)
Direct visualization of the gamma secretase‐generated carboxyl‐terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus (2002) (93)
In Vivo Multiphoton Imaging of a Transgenic Mouse Model of Alzheimer Disease Reveals Marked Thioflavine‐S‐Associated Alterations in Neurite Trajectories (2003) (93)
Plaque‐Induced Abnormalities in Neurite Geometry in Transgenic Models of Alzheimer Disease: Implications for Neural System Disruption (2001) (93)
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. (2006) (93)
Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. (2008) (93)
Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease. (1994) (92)
Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. (2003) (91)
Mild to moderate Alzheimer dementia with insufficient neuropathological changes (2014) (91)
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation (2018) (91)
Autoantibodies to Redox-modified Oligomeric Aβ Are Attenuated in the Plasma of Alzheimer's Disease Patients* (2005) (90)
Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease (2012) (90)
LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes. (2002) (90)
A highly insoluble state of Aβ similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice (2009) (90)
MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD (2008) (89)
Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking and Aβ Secretion* (2006) (89)
Orchestrated experience-driven Arc/Arg3.1 responses are disrupted in a mouse model of Alzheimer’s disease (2012) (89)
Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model (2014) (88)
ApoE isoforms affect neuronal N-methyl-d-aspartate calcium responses and toxicity via receptor-mediated processes (2003) (88)
Microtubule‐Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study (2000) (87)
Decreased Catalytic Activity of the Insulin-degrading Enzyme in Chromosome 10-Linked Alzheimer Disease Families* (2007) (86)
A direct demonstration of the perforant pathway terminal zone in Alzheimer's disease using the monoclonal antibody Alz-50 (1988) (86)
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. (2020) (86)
Stereology: A Practical Primer for Neuropathology (1998) (85)
Serum cystatin C and the risk of Alzheimer disease in elderly men (2008) (85)
Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system (2009) (85)
A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid (2015) (84)
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease (2019) (84)
Detection of novel intracellular O‐synuclein oligomeric species by fluorescence lifetime imaging (2006) (83)
Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys. (1994) (83)
Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-Sectional Study (2016) (83)
Apolipoprotein E ϵ4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis (1995) (83)
Soluble tau Species, Not Neurofibrillary Aggregates, Disrupt Neural System Integration in a tau Transgenic Model (2011) (82)
Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice (2011) (82)
Seed‐competent high‐molecular‐weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients (2016) (81)
Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets (2013) (81)
Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study. (2008) (81)
Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease. (1998) (80)
Developmental Regulation of Presenilin mRNA Expression Parallels Notch Expression (1997) (79)
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. (2017) (79)
Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease (2018) (79)
Trafficking of adeno‐associated virus vectors across a model of the blood–brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells (2017) (79)
Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation (2013) (79)
Abeta associated neuropil changes: correlation with neuronal loss and dementia. (1998) (79)
New neuropathological criteria for Alzheimer disease. (1998) (79)
Heparan Sulfate Accumulation with Aβ Deposits in Alzheimer's Disease and Tg2576 Mice is Contributed by Glial Cells (2008) (78)
The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity. (1997) (77)
A novel presenilin‐1 mutation: Increased β‐amyloid and neurofibrillary changes (1997) (77)
Polygenic hazard score: an enrichment marker for Alzheimer’s associated amyloid and tau deposition (2017) (77)
Notch1 and Amyloid Precursor Protein Are Competitive Substrates for Presenilin1-dependent γ-Secretase Cleavage* (2001) (77)
A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele (1996) (77)
Tau reduction in the presence of amyloid-&bgr; prevents tau pathology and neuronal death in vivo (2018) (76)
Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease (1994) (76)
Apolipoprotein E: Isoform Specific Differences in Tertiary Structure and Interaction with Amyloid-β in Human Alzheimer Brain (2011) (76)
The Challenge of Connecting the Dots in the B.R.A.I.N. (2013) (75)
Neuropathologic changes of the temporal pole in Alzheimer's disease and Pick's disease. (1994) (75)
Experimental evidence for the age dependence of tau protein spread in the brain (2019) (74)
The role of clusterin in amyloid-β-associated neurodegeneration. (2014) (74)
GROα/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation—a role in Alzheimer's disease? (2002) (74)
Colocalization and Fluorescence Resonance Energy Transfer between cdk5 and AT8 Suggests a Close Association in Pre‐Neurofibrillary Tangles and Neurofibrillary Tangles (2002) (74)
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. (1999) (73)
Kinetics of Cerebral Amyloid Angiopathy Progression in a Transgenic Mouse Model of Alzheimer Disease (2006) (73)
Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease (2016) (73)
Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology. (2002) (73)
α2-Macroglobulin Exposure Reduces Calcium Responses to N-Methyl-d-Aspartate via Low Density Lipoprotein Receptor-related Protein in Cultured Hippocampal Neurons* (2002) (73)
TAR-DNA Binding Protein 43 in Pick Disease (2008) (73)
Exosome-associated AAV vector as a robust and convenient neuroscience tool (2016) (72)
Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease (2016) (72)
Alzheimer's Disease‐Associated Ubiquilin‐1 Regulates Presenilin‐1 Accumulation and Aggresome Formation (2011) (72)
Transcriptional and conformational changes of the tau molecule in Alzheimer's disease. (2005) (71)
Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy (2009) (71)
Dopamine-Induced Conformational Changes in Alpha-Synuclein (2009) (71)
Epidemiological, Clinical, and Neuropathological Study of Apolipoprotein E Genotype in Alzheimer's Disease (1996) (69)
A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles (1989) (69)
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. (2007) (69)
Senile dementia associated with amyloid β protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-ε4 allele (2000) (68)
Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia (2017) (68)
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease (2009) (68)
Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations. (2000) (67)
MPP+Induced Substantia Nigra Degeneration Is Attenuated in nNOS Knockout Mice (1997) (67)
Dynamics of plaque formation in Alzheimer's disease. (1999) (67)
Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy. (2004) (67)
Expression and alternate splicing of apolipoprotein E receptor 2 in brain (1999) (67)
Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions (1992) (67)
Different tau species lead to heterogeneous tau pathology propagation and misfolding (2018) (67)
Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio (2009) (66)
Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo (2012) (66)
Pathologic Changes in the Olfactory System in Aging and Alzheimer's Disease a (1991) (66)
beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging. (2001) (66)
Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. (1999) (66)
Coordinated Expression of Caspase 8, 3 and 7 mRNA in Temporal Cortex of Alzheimer Disease: Relationship to Formic Acid Extractable A&bgr;42 Levels (2006) (65)
GGA1 Acts as a Spatial Switch Altering Amyloid Precursor Protein Trafficking and Processing (2006) (65)
Structure and Functions of Human Cerebrospinal Fluid Lipoproteins from Individuals of Different APOE Genotypes (1998) (65)
Modulation of Aβ Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background (2000) (65)
Mild cholesterol depletion reduces amyloid‐β production by impairing APP trafficking to the cell surface (2009) (64)
Single molecule profiling of tau gene expression in Alzheimer’s disease (2007) (64)
Unrecognized vitamin D3 deficiency is common in Parkinson disease (2013) (64)
Preoperative cognitive assessment of the elderly surgical patient: a call for action. (2011) (64)
Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. (2016) (64)
Regional Variation in the Distribution of Apolipoprotein E and Aβ in Alzheimer's Disease (1995) (64)
The Near Eastern Origin of Cat Domestication (2007) (64)
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575 (2009) (64)
Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: implications for MAP kinase activation in Alzheimer disease. (1999) (63)
Apolipoprotein E ε2 Allele and Risk of Stroke in the Older Population (1997) (63)
Interaction of α‐synuclein and synphilin‐1: effect of Parkinson's disease‐associated mutations (2001) (62)
Characterization of Oligomer Formation of Amyloid-β Peptide Using a Split-luciferase Complementation Assay* (2011) (62)
Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes (2014) (61)
MPP+Produces Progressive Neuronal Degeneration Which Is Mediated by Oxidative Stress (1997) (61)
Machine learning identifies candidates for drug repurposing in Alzheimer’s disease (2021) (61)
Plasma A&bgr; Levels Do Not Reflect Brain A&bgr; Levels (2007) (61)
Plasma F2A Isoprostane Levels in Alzheimer’s and Parkinson’s Disease (2007) (61)
A Reporter of Local Dendritic Translocation Shows Plaque- Related Loss of Neural System Function in APP-Transgenic Mice (2009) (61)
Transcriptional dysregulation in a transgenic model of Parkinson disease (2008) (61)
Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. (2015) (60)
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice (2021) (60)
Serine and Threonine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein by Protein Kinase Cα Regulates Endocytosis and Association with Adaptor Molecules* (2004) (60)
Synaptic phosphorylated &agr;-synuclein in dementia with Lewy bodies (2017) (59)
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. (2001) (59)
Effects of Simvastatin on Cholesterol Metabolism and Alzheimer Disease Biomarkers (2010) (59)
APOE ε3/ε4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer’s disease diagnosis (2003) (58)
Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening (2015) (58)
Low Density Lipoprotein Receptor-related Protein (LRP) Interacts with Presenilin 1 and Is a Competitive Substrate of the Amyloid Precursor Protein (APP) for γ-Secretase* (2005) (57)
Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells (2018) (57)
Ageing and dementia (2008) (57)
Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease (2013) (57)
Dissociation of apolipoprotein and apolipoprotein receptor response to lesion in the rat brain: An in situ hybridization study (1998) (57)
Global gene expression changes in rat retinal ganglion cells in experimental glaucoma. (2010) (57)
Accumulation of N‐3 Polyunsaturated Fatty Acids by Cultured Human Y79 Retinoblastoma Cells (1981) (57)
Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth (2010) (56)
A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease* (2014) (56)
Distinct Dendritic Spine and Nuclear Phases of Calcineurin Activation after Exposure to Amyloid-β Revealed by a Novel Fluorescence Resonance Energy Transfer Assay (2012) (56)
A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid (2013) (56)
Progression of Cerebral Amyloid Angiopathy in Transgenic Mouse Models of Alzheimer Disease (2005) (56)
Apolipoprotein E Genotype and Deposits of Aβ40 and Aβ42 in Alzheimer Disease (1998) (56)
An investigation of clinical correlates of Lewy bodies in autopsy-proven Alzheimer disease. (2001) (56)
Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains (2019) (55)
Alpha-Synuclein and Chaperones in Dementia With Lewy Bodies (2005) (55)
Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease. (1994) (54)
Direct detection of alpha synuclein oligomers in vivo (2013) (54)
Alzheimer's disease with and without coexisting Parkinson's disease changes (1995) (54)
Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. (1994) (54)
Amyloid, dementia and Alzheimer's disease. (1992) (53)
Polygenic hazard score, amyloid deposition and Alzheimer’s neurodegeneration (2019) (53)
Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65 (2018) (53)
Synergy between amyloid-beta and tau in Alzheimer’s Disease (2020) (52)
Choline Uptake in Cultured Human Y79 Retinoblastoma Cells: Effect of Polyunsaturated Fatty Acid Compositional Modifications (1982) (52)
Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase (2009) (52)
Fyn Modulation of Dab1 Effects on Amyloid Precursor Protein and ApoE Receptor 2 Processing* (2008) (52)
Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease (2012) (52)
Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies (2006) (52)
Notch1 Competes with the Amyloid Precursor Protein for γ-Secretase and Down-regulates Presenilin-1 Gene Expression* (2003) (52)
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities (2016) (52)
Chapter 20 Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease (1986) (51)
Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease (2017) (51)
Alzheimer Disease Therapeutics (2001) (51)
Alzheimer disease's double-edged vaccine (2003) (51)
Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site (2010) (51)
Non-Fibrillar Oligomeric Amyloid-β within Synapses. (2016) (50)
A roadmap for the prevention of dementia: The inaugural Leon Thal Symposium (2008) (50)
Reversal of Neurofibrillary Tangles and Tau-Associated Phenotype in the rTgTauEC Model of Early Alzheimer's Disease (2013) (49)
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron. (2010) (49)
Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. (2017) (49)
The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials. (2016) (48)
Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum (2016) (48)
Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue (2016) (48)
Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration (2013) (48)
Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms. (1999) (48)
In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility (2010) (48)
Synaptic Plasticity Defect Following Visual Deprivation in Alzheimer's Disease Model Transgenic Mice (2012) (47)
Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP) (2000) (47)
Stable Size Distribution of Amyloid Plaques Over the Course of Alzheimer Disease (2012) (47)
Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease. (1997) (46)
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity. (2004) (46)
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. (1996) (46)
Partial reduction of microglia does not affect tau pathology in aged mice (2018) (46)
Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum. (2014) (46)
Polygenic hazard scores in preclinical Alzheimer’s disease (2017) (45)
Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease (2017) (45)
No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer’s disease brain (2006) (45)
Exosome-associated AAV vector as a robust and convenient neuroscience tool (2016) (45)
Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain (2011) (44)
Imaging amyloid-beta deposits in vivo. (2002) (44)
Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9 (2016) (44)
In Vivo Imaging of Amyloid-ß Deposits in Mouse Brain With Multiphoton Microscopy (2005) (44)
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease (2010) (44)
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains (1998) (43)
Glutamate Receptor Dysregulation in the Hippocampus of Transgenic Mice Carrying Mutated Human Amyloid Precursor Protein (2001) (43)
Detection of Myelination Using a Novel Histological Probe (2005) (43)
Unraveling the Mystery of Cognitive Changes in Old Age: Correlation of Neuropsychological Evaluation With Neuropathological Findings in the Extreme Old (1998) (43)
Neuroethics Guiding Principles for the NIH BRAIN Initiative (2018) (43)
Formation, release, and internalization of stable tau oligomers in cells (2016) (42)
Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease (1999) (42)
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. (1998) (42)
Caspase activation without apoptosis: insight into Aβ initiation of neurodegeneration (2010) (40)
Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele. (2000) (40)
Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration (2020) (40)
A limited role for microglia in antibody mediated plaque clearance in APP mice (2007) (40)
In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease (2021) (39)
Rarity of the Alzheimer disease-protective APP A673T variant in the United States. (2015) (39)
Plasma A&bgr;, homocysteine, and cognition: The Vitamin Intervention for Stroke Prevention (VISP) trial (2009) (39)
Regulation of Dynamin Oligomerization in Cells: The Role of Dynamin–Actin Interactions and Its GTPase Activity (2014) (39)
Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. (1993) (39)
The pattern of NADPH-diaphorase staining, a marker of nitric oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer's disease (1993) (39)
Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions (1997) (39)
Tau Propagation, Different Tau Phenotypes, and Prion-like Properties of Tau (2014) (38)
&bgr;-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals (2018) (38)
Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice (2010) (38)
Dementia with Lewy Bodies (1998) (38)
Apolipoprotein E in Creutzfeldt-Jakob disease (1995) (38)
Systemic or Local Administration of Azide Produces Striatal Lesions by an Energy Impairment-Induced Excitotoxic Mechanism (1994) (38)
RNA Aptamer Probes as Optical Imaging Agents for the Detection of Amyloid Plaques (2014) (38)
Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration (2020) (38)
Glycine Uptake by Cultured Human Y79 Retinoblastoma Cells: Effect of Changes in Phospholipid Fatty Acid Unsaturation (1983) (37)
Rapid Notch1 Nuclear Translocation after Ligand Binding Depends on Presenilin‐associated γ‐Secretase Activity (2000) (37)
Neuritic Alterations and Neural System Dysfunction in Alzheimer's Disease and Dementia with Lewy Bodies (2003) (37)
Elevation of LDL Receptor‐Related Protein Levels via Ligand Interactions in Alzheimer Disease and In Vitro (2001) (37)
Uptake of fibrillar β-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice (2001) (36)
Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy (2014) (36)
Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains (2007) (36)
LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking (2011) (36)
GROalpha/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation-a role in Alzheimer's disease? (2002) (35)
Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy (2013) (35)
Genotyping of Apolipoprotein E: Comparative Evaluation of Different Protocols (2003) (34)
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease (2015) (34)
Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis. (1995) (34)
Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer’s disease (2004) (34)
APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. (2003) (34)
Biochemical and immunocytochemical characterization of calsenilin in mouse brain (2002) (34)
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Aβ and AICD generation (2005) (34)
Mouse gender influences brain transduction by intravascularly administered AAV9. (2013) (34)
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. (2003) (33)
Somatic genomic changes in single Alzheimer’s disease neurons (2022) (33)
Role of Apolipoprotein E in β-Amyloidogenesis (2015) (33)
Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons (2000) (33)
Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly (2016) (33)
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration (2002) (32)
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. (2001) (32)
Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV (2014) (32)
Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design (2017) (32)
Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques (2015) (32)
Plasma Abeta levels do not reflect brain Abeta levels. (2007) (32)
Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions (2013) (32)
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta (2016) (32)
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease (2001) (32)
Analysis of Cerebral Amyloid Angiopathy in a Transgenic Mouse Model of Alzheimer Disease Using In Vivo Multiphoton Microscopy (2001) (32)
Immunohistochemical localization of tissue factor pathway inhibitor-1 (TFPI-1), a Kunitz proteinase inhibitor, in Alzheimer's disease (1996) (32)
Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies (2000) (31)
Synaptic phosphorylated a-synuclein in dementia with Lewy bodies (2017) (31)
Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. (2008) (31)
Lack of association of trinucleotide repeat polymorphisms in the very‐low‐density lipoprotein receptor gene with Alzhelner's disease (1996) (31)
Physical and functional connection between auxilin and dynamin during endocytosis (2006) (31)
Effect of naltrexone on senile dementia of the Alzheimer type. (1985) (31)
Tau Prion-Like Propagation: State of the Art and Current Challenges. (2019) (30)
Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer’s disease (2013) (30)
An alternatively spliced form of rodent α-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in α-synuclein aggregation (2002) (30)
Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease (2015) (30)
In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. (2005) (30)
Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies (2001) (30)
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. (2006) (30)
Localization of non–N‐methyl‐D‐aspartate glutamate receptors in normal and Alzheimer hippocampal formation (1994) (29)
Apolipoprotein E epsilon 2 allele and risk of stroke in the older population. (1997) (29)
Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. (2005) (29)
Structural studies on the mechanism of protein aggregation in age related neurodegenerative diseases (2016) (29)
Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons (1994) (28)
Neuroanatomical connections and specific regional vulnerability in Alzheimer's disease (1993) (28)
A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. (1997) (28)
Effects of Ubiquilin 1 on the Unfolded Protein Response (2009) (28)
Multiple myeloma with polyneuropathy and coagulopathy. A case report of the polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin change (POEMS) syndrome. (1986) (28)
alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. (2002) (28)
Performance characteristics of plasma amyloid-beta 40 and 42 assays. (2009) (28)
Risperidone treatment of behavioral disturbances in outpatients with dementia. (1999) (28)
Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease (2020) (27)
Low‐density lipoprotein receptor‐related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1 (2002) (27)
The NIH BRAIN Initiative: Integrating Neuroethics and Neuroscience (2019) (27)
Neuroanatomy of Alzheimer's disease: Hierarchical vulnerability and neural system compromise (1995) (27)
Tau–amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid‐induced disruption of axonal projections and exacerbated axonal pathology (2013) (27)
Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis (2011) (27)
Characterization of TauC3 antibody and demonstration of its potential to block tau propagation (2017) (27)
Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production (2017) (27)
CA3 neuronal degeneration follows chronic entorhinal cortex lesions (1995) (27)
Family-Based Association between Alzheimer ’ s Disease and Variants in UBQLN 1 (2005) (26)
Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. (2015) (26)
3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice (2016) (26)
Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. (1993) (26)
Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study (2011) (26)
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. (2006) (26)
A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model (2009) (26)
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (26)
Alz-50 immunoreactivity in the thalamic reticular nucleus in Alzheimer's disease (1990) (26)
Angiotensin II protects against α-synuclein toxicity and reduces protein aggregation in vitro (2007) (26)
Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. (2011) (25)
The Natural History of Alzheimer Neurofibrillary Tangles and Amyloid Deposits (1997) (25)
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. (2005) (25)
Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons. (2001) (25)
Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease. (1986) (25)
Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes. (2018) (25)
Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism (2021) (25)
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells (2006) (24)
Hemianesthesia and aphasia. An anatomical and behavioral study. (1989) (24)
Alzheimer’s Disease: What Multiphoton Microscopy Teaches Us (2002) (24)
Molecular epidemiology of Alzheimer's disease. (1995) (24)
Alz-50 immunoreactivity in the neonatal rat: Changes in development and co-distribution with MAP-2 immunoreactivity (1989) (23)
Erratum: Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease (Neuron (2018) 99(5) (925–940.e7), (S0896627318306378) (10.1016/j.neuron.2018.07.039)) (2019) (23)
Interaction between Presenilin 1 and Ubiquilin 1 as Detected by Fluorescence Lifetime Imaging Microscopy and a High-throughput Fluorescent Plate Reader* (2006) (23)
Animal Model Age-Related Amyloid b Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid b Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss (2000) (23)
Effects of aging on quinolinic acid lesions in rat striatum (1991) (23)
Neuropathology of Alzheimer's disease. (2008) (23)
Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle (2019) (23)
APOE4 derived from astrocytes leads to blood–brain barrier impairment (2021) (22)
PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy (2020) (22)
Dynamic feedback in an aggregation-disaggregation model. (1999) (22)
A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease (2020) (22)
Alzheimer's disease or Alzheimer's diseases? clues from molecular epidemiology (1996) (21)
The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1) (2015) (21)
A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain (2018) (21)
N‐cadherin‐based adhesion enhances Aβ release and decreases Aβ42/40 ratio (2009) (21)
Lack of allelic imbalance in APOE ϵ3/4 brain mRNA expression in Alzheimer's disease (1999) (21)
Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses (2014) (21)
Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease (2021) (20)
Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery (2018) (20)
Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease (2021) (20)
Disordered proteins in dementia (2002) (20)
Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns (2020) (20)
Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site (2003) (20)
Edinburgh Research Explorer Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation (2018) (20)
Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study. (2020) (20)
Neuron recognition by parallel Potts segmentation (2003) (20)
Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease. (1998) (20)
γ-Secretase Heterogeneity in the Aph 1 Subunit : Relevance for Alzheimer ’ s Disease (2009) (20)
Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies (2020) (19)
The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort (2015) (19)
Current directions in tau research: Highlights from Tau 2020 (2021) (19)
Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. (2017) (19)
Functional alterations in neural circuits in Alzheimer's disease (1995) (19)
Cerebral amyloid angiopathy and apolipoprotein E: Bad news for the good allele? (1997) (19)
An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation. (2002) (18)
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors (2021) (18)
Opposing Roles of apolipoprotein E in aging and neurodegeneration (2019) (18)
Brain Oligomeric A -Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice (2011) (18)
Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells. (2008) (18)
Connections and Cognitive Impairment in Alzheimer’s Disease (1997) (18)
Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay (2017) (18)
The neuropathology of Williams syndrome. Report of a 35-year-old man with presenile beta/A4 amyloid plaques and neurofibrillary tangles. (1995) (17)
Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain (2010) (17)
Neuronal expression of class II major histocompatibility complex (HLA-DR) in 2 cases of Pick disease. (1997) (17)
T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice (2011) (16)
Monitoring proteins in intact cells. (2003) (16)
Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. (2008) (16)
Pathogenic PS1 phosphorylation at Ser367 (2017) (16)
Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease (2019) (16)
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients (2000) (16)
Calcineurin activation causes retinal ganglion cell degeneration (2012) (15)
Failure analysis of clinical trials to test the amyloid hypothesis (2014) (15)
Glycogen synthase kinase 3α and 3β do not colocalize with neurofibrillary tangles (1996) (15)
Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11 (2009) (15)
Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice (2016) (14)
Neurofibrillary tangles and olfactory dysgenesis (1991) (14)
Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo. (2018) (14)
Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein (2012) (14)
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model (2021) (14)
Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. (2006) (14)
Apolipoprotein E genotype: utility in clinical practice in Alzheimer's disease. (1996) (14)
Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss (2021) (14)
Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint (2016) (14)
Visit-to-Visit Blood Pressure Variability, Neuropathology, and Cognitive Decline (2021) (13)
Apolipoprotein E ϵ4/4 in a Neuropathologically Normal Very Elderly Individual (1996) (13)
Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics (2014) (13)
Statistical physics and Alzheimer’s disease (1998) (13)
EM Structure of the Ectodomain of Integrin CD11b/CD18 and Localization of Its Ligand-Binding Site Relative to the Plasma Membrane (2013) (13)
Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau. (2013) (13)
Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons. (2006) (13)
Apolipoprotein E, Aβ, and Alzheimer Disease. An Editorial Comment (1994) (13)
Scaling and universality in living systems (1996) (13)
Extracellular signal-regulated kinase (MAP kinase) immunoreactivity in the rhesus monkey brain (1994) (12)
Preclinical characterization of amyloid imaging probes with multiphoton microscopy. (2006) (12)
Neuron numbers in Alzheimer's disease: Cell-specific pathology (1987) (12)
β-Glucocerebrosidase Activity in GBA-linked Parkinson's Disease: The Type of Mutation Matters. (2020) (12)
Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain (2018) (12)
Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease. (1999) (12)
Molecular and anatomical studies in Alzheimer's disease. (2001) (12)
Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system (2021) (11)
Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease (2021) (11)
Featured Articles National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (2012) (11)
The SIST-M: Predictive Validity of a Brief Structured Clinical Dementia Rating Interview (2012) (11)
Genome-wide association study and functional validation implicates JADE1 in tauopathy (2021) (10)
ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model. (2021) (10)
ALPHA SYNUCLEIN IMMUNOREACTIVITY IN DEMENTIA WITH LEWY BODIES (1999) (10)
Microscopic imaging of intracellular calcium in live cells using lifetime-based ratiometric measurements of Oregon Green BAPTA-1. (2011) (10)
Alzheimer's disease. (1989) (10)
Normal Aging and Alzheimer's Disease (1998) (10)
Brain isoprostanes (2003) (10)
Measuring caspase activity in vivo. (2014) (10)
Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. (2003) (10)
Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis (2021) (10)
No Evidence of PGRN or MAPT Gene Dosage Alterations in a Collection of Patients with Frontotemporal Lobar Degeneration (2009) (9)
Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking (2006) (9)
Novel Progranulin Mutation Detected in 2 Patients With FTLD (2011) (9)
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease (2012) (9)
Studies of Amyloid β‐Protein Precursor Expression in Alzheimer's Disease (1991) (9)
Olfactory dysgenesis or hypoplasia (1992) (9)
Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics (2021) (9)
> -Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease (2009) (9)
Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro. (2007) (9)
Personalized genetic assessment of age associated Alzheimer’s disease risk (2016) (9)
Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease (1999) (9)
Multiphoton microscopy and amyloid angiopathy. (2001) (9)
Apolipoprotein E levels and Alzheimer risk (2015) (9)
Functional integrity of neural systems related to memory in Alzheimer's disease. (1994) (8)
Down syndrome and Alzheimer disease. (1992) (8)
Neuronal loss in Alzheimer's disease. (1998) (8)
α-Synuclein strains target distinct brain regions and cell types (2019) (8)
"Connections, Cognition and Alzheimer's Disease" (2011) (8)
A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. (2014) (8)
Apolipoprotein E epsilon4/4 in a neuropathologically normal very elderly individual. (1996) (8)
The Structured Interview & Scoring Tool-Massachusetts Alzheimer's Disease Research Center (SIST-M): development, reliability, and cross-sectional validation of a brief structured clinical dementia rating interview. (2011) (8)
Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease (2021) (8)
Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease. (2006) (8)
Conformational fingerprinting of tau variants and strains by Raman spectroscopy (2021) (8)
Differences in Assessment of Everyday Preferences Between People With Cognitive Impairment and Their Care Partners: The Role of Neuropsychiatric Symptoms. (2020) (7)
GERIATRIC BIOSCIENCE: Apolipoprotein E Genotype: Utility in Clinical Practice in Alzheimer's Disease (1996) (7)
Dendritic spine abnormalities in APP transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy (2008) (7)
Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death (2018) (7)
Alternatives to amyloid for Alzheimer's disease therapies—a symposium report (2020) (7)
AFFERENTS OF THE THALAMIC RETICULAR NUCLEUS ARE PATHOLOGICALLY ALTERED IN ALZHEIMERʼS DISEASE: 105 (1989) (7)
β-Glucocerebrosidase activity in GBA-linked Parkinson disease (2020) (7)
Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post‐mortem motor cortex and cerebrospinal fluid (2021) (7)
A Close Association of TorsinA and α-Synuclein in Lewy Bodies (2001) (7)
Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts (2018) (7)
Massachusetts Alzheimer's Disease Research Center: Progress and challenges (2015) (7)
EVALUATION OF NIA-REAGAN INSTITUTE CRITERIA FOR THE NEUROPATHOLOGICAL DIAGNOSIS OF ALZHEIMER DISEASE (1997) (7)
Neurobiology of Disease Apolipoprotein E , Especially Apolipoprotein E 4 , Increases the Oligomerization of Amyloid Peptide (2017) (7)
Interpretable deep learning of myelin histopathology in age-related cognitive impairment (2022) (6)
567. CRISPR-Cas9 Mediated Gene Editing in a Monogenic Form of Alzheimer's Disease (2016) (6)
Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1). (2013) (6)
Drug repurposing of metformin for Alzheimer disease: Combining causal inference in medical records data and systems pharmacology for biomarker identification (2021) (6)
Impairment of visual cortical plasticity by amyloid-beta species (2021) (6)
The Living Brain and Alzheimer's Disease (2004) (6)
LRP1 is a master regulator of tau uptake and spread (2020) (6)
A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type (2018) (6)
Effects of Species-Specific Genetics on Alzheimer’s Mouse Models (2019) (6)
Improved design of prodromal Alzheimer's disease trials through cohort enrichment and surrogate endpoints. (2013) (6)
TOPOGRAPHIC DISTRIBUTION OF ALZHEIMER NEURONAL CHANGES IN NORMAL AGING BRAINS. AN IMMUNOHISTOCHEMICAL STUDY WITH ALZ-50: 226 (1990) (6)
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. (1996) (6)
Segmentation of Tau Stained Alzheimers Brain Tissue Using Convolutional Neural Networks (2020) (6)
TAU PET USING F18-T807: INITIAL EXPERIENCE IN NORMAL ELDERLY AND AD DEMENTIA (2014) (6)
Alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Relationship to apolipoprotein E and role in Alzheimer disease senile plaques. (1994) (5)
Hippocampal and enthorhinal cortex cellular pathology in Alzheimer's disease (1989) (5)
[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease (2022) (5)
Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer’s cases (2021) (5)
In vivo multiphoton microscopy of deep tissue with gradient index lenses (2004) (5)
Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons (2021) (5)
Tau at the Crossroads between Neurotoxicity and Neuroprotection (2017) (5)
Neuropathological markers of impaired cognition in the entorhinal cortex (1996) (5)
The LDL receptor-related protein can form homo-dimers in neuronal cells (2008) (5)
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease (1998) (5)
APOE genotype and brain development. (2014) (5)
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease (2022) (5)
The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue. (2020) (5)
Anatomy of Pathological Alterations in Alzheimer’s Disease (1997) (5)
Tau reduction in aged mice does not impact Microangiopathy (2020) (5)
β-Site APP Cleaving Enzyme mRNA Expression in APP Transgenic Mice (2001) (5)
Studying the Alzheimer's disease brain: Insights, puzzles, and opportunities (1994) (4)
Alzheimer disease Cerebrospinal Fluid biomarker in Cognitively Normal Subjects : Multicenter 1 Study 2 (2015) (4)
Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans. (2020) (4)
In vivo evaluation and imaging of a lipophilic derivative of Congo red for amyloid assessments (2001) (4)
Apolipoprotein E--Correction (1995) (4)
Can the immune system fight Alzheimer disease? (2006) (4)
Studying protein degradation pathways in vivo using a cranial window-based approach. (2011) (4)
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2022) (4)
Apolipoprotein E, A beta, and Alzheimer disease. (1994) (4)
Activation de caspases et formation de dégénérescences neurofibrillaires dans un modèle murin de la maladie d’Alzheimer (2010) (4)
Anatomical changes underlying dementia in Alzheimer’s disease (2006) (4)
40 PATHOLOGIC CHANGES IN ALZHEIMERʼS DISEASE SPECIFICALLY DISRUPT HIPPOCAMPAL CONNECTIONS (1984) (4)
Limbic cortical projections to sensory and multi modal association areas in the old world monkey (1988) (4)
APOEε2 Is Associated With Milder Clinical and Pathological Alzheimer’s Disease (S16.005) (2015) (4)
P3-423 Molecular dissection of the interaction between APP and its neuronal trafficking receptor SorLA/LR11 (2006) (4)
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein (2019) (4)
LACK OF ACCUMULATION OF SENILE PLAQUES OR AMYLOID BURDEN IN AGING, ALZHEIMERʼS DISEASE AND DOWN SYNDROME (1993) (4)
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90 (2022) (4)
[Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease]. (2010) (4)
Biomarkers in Alzheimer’s Disease (1998) (4)
Entorhinal, parahippocampal, and inferior temporal F18-T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly (2015) (4)
Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome (2017) (4)
Plasma A A Levels Do Not Reﬂect Brain A A Levels (2007) (4)
Effects of Age and Ethnicity on the Link Between APOE ∊4 and Alzheimer Disease—Reply (1998) (3)
Tau propagation is dependent on the genetic background of mouse strains (2022) (3)
Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets (2013) (3)
Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease (2022) (3)
P3-084 Differential regulation of plasma Aβ40 and Aβ42 levels with aging in the Uppsala Longitudinal Study of Adult Men (ULSAM) (2006) (3)
A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid (2015) (3)
Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum (2021) (3)
All the Tau We Cannot See. (2022) (3)
10 – Protein Aggregation Disorders (2007) (3)
Clinical and neuropathological features of dementia with Lewy bodies (1998) (3)
Lipid associated polygenic enrichment in Alzheimer’s disease (2018) (3)
Predictors of the importance of everyday preferences for older adults with cognitive impairment. (2021) (3)
LRP1 and SORL1 regulate tau internalization and degradation and enhance tau seeding (2020) (3)
A Nuclear Magnetic Resonance Spectroscopy Method in Characterization of Blood Metabolomics for Alzheimer’s Disease (2022) (3)
A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization (2022) (3)
Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease (2021) (3)
Longitudinal differences in everyday preferences: Comparisons between people with cognitive impairment and their care partners (2021) (3)
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia (2022) (3)
The HSV-1 iBAC amplicon vector for functional genomics studies into the genetic mechanisms of neurodegenerative disease (2004) (3)
Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids (2021) (3)
Chronic imaging of amyloid plaques in the live mouse brain using multiphoton microscopy (2001) (3)
Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment (2022) (3)
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities (2016) (2)
Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau (2021) (2)
IN VIVO MULTIPHOTON IMAGING OF AMYLOID DEPOSITION IN TRANSGENIC MICE (1999) (2)
Pathologic Changes in the Multimodal Association Areas of the Superior Temporal Sulcus in Alzheimer's Disease (1987) (2)
Testing the neuroinflammatory role of tau‐induced transposable elements in tauopathy (2021) (2)
Plasma beta-amyloid linked to cognitive decline. (2011) (2)
Reproducible quantification of fiber integrity profiles in the cingulum and the fornix using an experimental 32 channel head coil (2007) (2)
MULTIPHOTON IMAGING OF ALZHEIMER??S DISEASE NEUROPATHOLOGY: (1998) (2)
Pro-cathepsin D interacts with the extracellular domain of the LRP1 chain and promotes LRP1-dependent fibroblast outgrowth (2010) (2)
T cell mediated cerebral hemorrhages and microhemorrhages during passive A immunization in APPPS 1 transgenic mice (2011) (2)
Chemokines in the Central Nervous System and Alzheimer's Disease (2002) (2)
Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer’s Disease (2020) (2)
Apolipoprotein E in Creutzfeldt-Jacob disease. (1995) (2)
Tau and Alzheimer pathobiology (2016) (2)
Understanding the memory loss of Alzheimer's disease (1986) (2)
A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples (2021) (2)
EXPLORATION OF PLASMA BIOMARKERS FOR ALZHEIMER'S DISEASE USING ISOTOPIC TANDEM MASS TAGS AND A COMBINED DIRECTED/DATA-DEPENDENT ACQUISITION NLC-MS/MS METHOD (2014) (2)
An automatic method for spine detection and spine tracking in in vivo images (2007) (2)
CEREBRAL INFARCTION CONTRIBUTES TO THE HETEROGENEITY OF ALZHEIMERʼS DISEASE (AD) (1997) (2)
Multimodal optical imaging of mouse Ischemic cortex (2005) (2)
TYPE B IL-8 RECEPTOR (IL-8RB) IN NEURITIC PLAQUES OF ALZHEIMERʼS DISEASE (1996) (2)
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease (2015) (1)
P4-108: Serum cystatin C and the risk of Alzheimer's disease (2008) (1)
Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds (2020) (1)
Brain-wide charting of neuronal activation maps with cellular resolution (2015) (1)
Planning large-scale Alzheimer's disease questionnaire-aided studies (PLAQUES): Concordance of remote assessment methods with in-person diagnosis (2013) (1)
An in-depth analysis of phosphorylated tau in amyotrophic lateral sclerosispost-mortem motor cortex and cerebrospinal fluid (2021) (1)
Parallel tales of a changing brain (2001) (1)
Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis (2021) (1)
Cross-inhibition of beta-amyloid plaque formation by alpha-synuclein (2013) (1)
Natural Language Processing to Detect Cognitive Concerns in Electronic Health Records Using Deep Learning (2020) (1)
LRP1 mediates tau endocytosis in a process that is modulated by apolipoprotein E (2020) (1)
ApoE isoforms differentially regulate neuronal membrane proteasomes to shift the threshold for pathological aggregation of endogenous Tau (2022) (1)
O3-03-04 Novel approaches for non-invasive optical detection of amyloid-β plaques in vivo (2004) (1)
Altered localization of nucleoporin 98 in primary tauopathies (2022) (1)
Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system. (2021) (1)
In situ SAXS of protein deposits in Alzheimer’s disease (2019) (1)
Using Deep Learning to Identify Patients with Cognitive Impairment in Electronic Health Records (2021) (1)
Fas receptor and neuronal cell death after ischemia (2000) (1)
ALZ‐50 STAINING IMPLICATES CORTICO‐CORTICAL PATHWAYS IN THE PATHOLOGY OF ALZHEIMER'S DISEASE.: 11 (1987) (1)
ALZHEIMER DISEASE DOES NOT PROTECT THE NEOSTRIATUM IN COMBINED CASES OF HUNTINGTON (HD) AND ALZHEIMER DISEASE (AD) (1997) (1)
The natural history of Alzheimer disease dissected through multiphoton imaging of transgenic mice. (2006) (1)
Reversible acylation and inhibition of aggregation of platelets by substituted maleic anhydrides. (1977) (1)
NEURONAL LOSS IN ALZHEIMERʼS DISEASE: RELATION TO TANGLES, PLAQUES, AND APOLIPOPROTEIN E (1996) (1)
Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer’s disease (2020) (1)
Polygenic overlap between C-reactive protein , plasma lipids and Alzheimer ’ s disease 1 2 (2017) (1)
Machine Learning Identifies Novel Candidates for Drug Repurposing in Alzheimer’s Disease (2020) (1)
Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD (2021) (1)
Identification of a novel deletion in the splice donor site of progranulin exon 6 (2009) (1)
Longitudinal Changes in Neuropsychiatric Symptoms: Impact of Discrepancy in Everyday Preferences Between Persons with Cognitive Impairment and their Care Partners (2021) (1)
Apolipoprotein E and Apolipoprotein E Receptors in the Central Nervous System: Relationship with Alzheimer’s Disease (1996) (1)
HEPARAN SULFATE LABELING IN NEOCORTEX OF ALZHEIMERʼS DISEASE PATIENTS (1997) (1)
Alzheimer disease: Alzheimer dementia with sparse amyloid—AD mimic or variant? (2015) (1)
Serine and threonine phosphorylation of the LDL receptor-related protein (LRP) by protein kinase C αααα regulates endocytosis and association with adaptor molecules. (2004) (1)
Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration (2013) (1)
16 – The Molecular Basis of Alzheimer's Disease (2007) (1)
Tau propagation is dependent on the genetic background in multiple mouse strains (2020) (1)
Colocalization of Parkin with α-Synuclein in the Lewy Bodies of Parkinson Disease (2002) (1)
International conference on biomedical aspects of aging research (1998) (1)
Multiphoton imaging in mouse models of Alzheimer's disease (2004) (1)
THE EXPRESSION OF ALZHEIMERʼS DISEASE CHROMOSOME 14Q24.3 GENE PRESENILIN-1(PS1) IN RAT BRAIN AND IN RESPONSE TO EXCITOTOXIC BRAIN INJURY (1996) (1)
Development and Evaluation of a Natural Language Processing Annotation Tool to Facilitate Phenotyping of Cognitive Status in Electronic Health Records: Diagnostic Study (2022) (1)
Dysregulation of Intracellular Calcium in Alzheimer's Disease (2010) (1)
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta (2016) (1)
Direct detection of alpha synuclein oligomers in vivo (2013) (1)
Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer’s Disease (2023) (1)
Common mouse models of tauopathy reflect early but not late human disease (2023) (1)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020) (0)
CONSEQUENCES OF APOE2 OVEREXPRESSION IN ASTROCYTES IN AN ALZHEIMER'S DISEASE MOUSE MODEL (2014) (0)
Novel Ca2+-dependent interactions of presenilin 1 with synaptic proteins (2013) (0)
P3-416: Aβ stimulation leads to elevated levels of heparan sulfate proteoglycans in glial cells (2008) (0)
P3-434 In vivo multiphoton imaging reveals plaque-related deficits in structural plasticity, underlying dendritic spine loss in Tg2576 mice (2006) (0)
Interaction of Engulfment Adaptor Protein (GULP) and Amyloid Precursor Protein (APP) decreases Aβ40/42 secretion (2009) (0)
GGA1 overexpression alters trafficking and subcellular distribution of the amyloid precursor protein (2005) (0)
Cyclic Multiplex Fluorescent Immunohistochemistry Protocol to Phenotype Glial Cells in Formalin-Fixed Paraffin-Embedded Human Brain Sections. (2023) (0)
Chronic electrophysiology reveals age related loss of coherence between hippocampus and entorhinal cortex in ThyTau22 mice (2022) (0)
Active deep learning to detect cognitive concerns in electronic health records (2021) (0)
Oligomeric soluble beta-amyloid species induce calcium dyshomeostasis in the healthy living mouse brain (2013) (0)
Genetic analysis of the FE65 intron 13 biallelic polymorphism in a family-based and a case control study (2000) (0)
Reply (1994) (0)
Tau imaging : pathologic correlations 3 Number of words in the body of the manuscript : 3535 Number of figures : 5 Number of color figures : 4 Number of tables : 0 (2016) (0)
P3-229 Analysis of gene expression in the Alzheimer's disease brain (2004) (0)
Reply (1996) (0)
Plasma biomarkers of neuroinflammation and vascular injury predict cognitive decline in patients with mild cognitive impairment (2020) (0)
Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds. (2021) (0)
Aβ oligomerization is associated with the generation of a typical peptide fragment 1 fingerprint . 2 3 (2017) (0)
In situ structural biology of pathological protein deposits in Alzheimer's disease (2022) (0)
P4-256: Monitoring of tau-tubulin interactions with second harmonic generation (2008) (0)
On genetic pleiotropy between Alzheimer's disease and cardiovascular risk factors (2012) (0)
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue (2022) (0)
Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging (2023) (0)
Retinal bloodflow in mild cognitive impairment and Alzheimer's disease (2015) (0)
Folate deficiency accelerates Alzheimer's disease related pathology in APP/PS1 mice (2013) (0)
In Situ Studies of Fibrillar Polymorphs in Alzheimer's Disease (2021) (0)
From genetic defects to molecular pathogenesis of memory and movement disorders (2021) (0)
Geriatric Anesthesia Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-sectional Study (2016) (0)
Role of APOE in Alzheimer's disease-like neurodegeneration (2000) (0)
Lack of endogenous tau permits tau spreading and protects against tau toxicity in transgenic mice (2015) (0)
The amyloid paradox resolved — thioflavine positive abeta deposits lead to local neuropil damage and neuronal death (2000) (0)
Size matters: the impact of nucleus size on results from spatial transcriptomics (2022) (0)
402 ApoE- and apoAI-containing lipoproteins in the CNS (1996) (0)
EFFECTS OF AGE AND ETHNICITY ON THE LINK BETWEEN APOE EPSILON 4 AND ALZHEIMER DISEASE. AUTHORS' REPLY (1998) (0)
In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?” (2008) (0)
Unsupervised learning on electronic health records to uncover heterogeneity in Alzheimer’s disease and related dementias (2022) (0)
OP-JNEN200109 1141..1146 (2020) (0)
Heterogeneity of tau deposition and microvascular involvement in MCI and AD (2021) (0)
P3-076: CSF Tau levels and APOEϵ4 carriership predict the progression of mild cognitive impairment to Alzheimer's disease (2008) (0)
P4-324 Nonsteroidal anti-inflammatory drugs (NSAIDS) lower Aβ 42 and change presenilin1 confomation (2004) (0)
P3-222: Genetic regulation of Aβ levels in human plasma (2008) (0)
Optimization of biosensor cell lines for the detection of tau seeding competency in human CSF (2021) (0)
Quantitative analysis ofsenile plaques inAlzheimer disease: Observation oflog-normal sizedistribution andmolecular epidemiology ofdifferences associated withapolipoprotein E genotype andtrisomy 21(Downsyndrome) (1995) (0)
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo (2018) (0)
Explorer Calcineurin inhibition with systemic FK 506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain (2018) (0)
P2-164: In vivo multiphoton imaging of neurofibrillary tangles: Relationship to cell death cascades (2008) (0)
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease (2020) (0)
A brain atlas of astrocyte transcriptomics unveils complex states and responses to Alzheimer’s disease neuropathology (2022) (0)
Edinburgh Research Explorer The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system (2018) (0)
Single‐Neuron Genome Sequencing in Alzheimer’s Disease Identifies Disease‐Specific Somatic Alterations and Insights into Pathogenesis (2022) (0)
TEMPORAL NEOCORTICAL TAU DEPOSITION MEASURED WITH PET IS ASSOCIATED WITH LONGITUDINAL DECLINE IN MEMORY PERFORMANCE AMONG CLINICALLY NORMAL ELDERLY (2014) (0)
IC-103-03 Amyloid deposition in presymptomatic familial Alzheimer’s disease (2006) (0)
P2-160 Csf Aβ and tau levels in Alzheimer’s disease and mild cognitive impairment (2006) (0)
University of Dundee Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer ' s disease (2017) (0)
Employing an in vitro biosensor assay to investigate tau seeding kinetics within cases of sporadic Alzheimer disease and in a model of tauopathy (2020) (0)
P1-486: Decreased neuronal activity in APP transgenic mice measured via dendritic protein synthesis (2008) (0)
Chaperone mediated degradation of aggregated alpha synuclein (2004) (0)
Reply (1996) (0)
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease (2018) (0)
Elucidation of Amyloid-Beta’s Gambit in Oligomerization: Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, LMW Aβ oligomers that impair synaptic plasticity (2022) (0)
Erratum to: Are Tangles as Toxic as They Look? (2011) (0)
γ-Secretase inhibitors which have been shown to block Aβ production do not abolish Notch1 signaling (2000) (0)
Characterization of glial responses in Alzheimer’s disease with cyclic multiplex fluorescent immunohistochemistry and machine learning (2021) (0)
Edinburgh Research Explorer Human tau increases amyloid plaque size but not amyloid mediated synapse loss in a novel mouse model of Alzheimer's disease (2018) (0)
Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease (2014) (0)
Brain transcriptomes and plasma proteins reveal upregulation of a proinflammatory signature in APOE e4 carriers (2020) (0)
Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains (2023) (0)
Edinburgh Explorer Soluble forms of tau are toxic in Alzheimer's disease (2018) (0)
Entorhinal, parahippocampal, and inferior temporal F18-T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly (2015) (0)
Explorer Caspase activation precedes and leads to tangles (2016) (0)
Edinburgh Research Explorer Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer¿s disease (2018) (0)
312. Highly-Efficient CNS Transduction With Vesicle-Associated AAV Vector (2015) (0)
Projection of Care Partners’ Preferences in the Proxy Assessments of Everyday Preferences for Persons with Cognitive Impairment (2022) (0)
Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue (2022) (0)
Reply (1987) (0)
EXPRESSION OF NOTCH PROTEIN IN ADULT BRAIN PARALLELS THE EXPRESSION OF PRESENILINI, AND IS ELEVATED IN ALZHEIMER DISEASE (1998) (0)
Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration (2020) (0)
Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum (2023) (0)
Transgenic mice expressing mutant and wild type human presenilin-I (PS-1) (1997) (0)
Non-fibrillar oligomeric amyloid-β within synapses: Data set from publication Pickett et al 2016 J Alz Dis (2016) (0)
Role of LPR in A metabolism and Alzheimers disease. (2000) (0)
Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses (2014) (0)
P1-304 Geldanamycin inhibits but does not reverse alpha-synuclein aggregation (2004) (0)
P2-268 Amyloid deposition in presymptomatic familial Alzheimer’s disease (2006) (0)
Interneuron diversity in the human dorsal striatum (2023) (0)
Dopamine-Induced Conformational Changes in Alpha-Synuclein share how this access benefits you. Your story matters (2009) (0)
Selective loss of episodic memory of odor percepts is associated with progression to amnestic MCI or Alzheimer’s disease in cognitively healthy seniors (2020) (0)
Examination of the pathological mechanism of the microtubule associated protein tau using an HSV amplicon based neuronal gene delivery system (2003) (0)
Transcriptomic Differences in Endothelial Cells Across Five Brain Regions in Normal Aging and Alzheimer's Disease (2022) (0)
1st Conference Clinical Trials on Alzheimer’s Disease September 17-18-19, 2008 School of Medecine Montpellier, France (2008) (0)
In vivo imaging of amyloid deposits in transgenic models of Alzheimer's disease using multi-photon microscopy (2000) (0)
Apolipoprotein E Genotype and Deposits of A (cid:98) 40 and A (cid:98) 42 in Alzheimer Disease (2000) (0)
Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain (2017) (0)
The First Annual BU Neurology Symposium (2015) (0)
Spine tingling polymorphisms—Is apolipoprotein E involved in dendritic shape and plasticity? (2007) (0)
Computational Interspecies Translation Between Alzheimer’s Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging (2021) (0)
Tau reduction in aged mice does not impact Microangiopathy (2020) (0)
P2-194: Complement pathways are upregulated in angular gyrus of primary progressive aphasia cases (2008) (0)
α-SYNUCLEIN IMMUNOREACTIVE NEURONAL CYTOPLASMIC INCLUSIONS AND AXONAL SWELLINGS IN NEUROAXONAL DYSTROPHY (1999) (0)
Imaging the Pathology of Alzheimer's Disease: Amyloid-Imaging with PET (2003) (0)
Characterization of the Monoamine Oxidase-B (MAO-B) Expression in Postmortem Normal and Alzheimer’s Disease Brains (S39.006) (2023) (0)
Plaque-induced neurite abnormalities in TG2576 HAPPSW over-expressing transgenic mice: Special role of thioflavine S plaques and implications for disruption of the neuropil (2000) (0)
Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment (2022) (0)
Designed helical peptide probes for the initial substrate docking site of gamma - secretase (2003) (0)
Clearance of endogenous soluble Aβ in neuronal and glial cultures (2000) (0)
Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4 (2011) (0)
Retinal Blood Flow and Nerve Fiber Layer Thickness in Patients with Mild Cognitive Impairment or Probable Alzheimer's Disease (2011) (0)
In Vivo Imaging of Alzheimer Pathology in Transgenic Mice using Multiphoton Microscopy (2004) (0)
Explorer Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease (2017) (0)
P3-009 Cross-sectional measures of plasma amyloid-beta protein do not correlate with functional status in prodromal Alzheimer's disease (2004) (0)
Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells (2018) (0)
O4-02-01: Interaction of sorLA/LR11 with multiple members of the low-density lipoprotein receptor family (2008) (0)
P-030 MRI-based longitudinal measures of temporoparietal regions show differential rates of atrophy during prodromal Alzheimer’s disease (2007) (0)
616. Tailored Expression of a Transgene to Specific Cell Types in the Central Nervous System After Peripheral Injection of AAV9 (2016) (0)
O3-05-05 Molecular conformation of PS1 is affected by FAD mutations (2004) (0)
Constructs used in this study and complementation results. (2013) (0)
Author response: Pathogenic PS1 phosphorylation at Ser367 (2016) (0)
Message from the Editors (2007) (0)
RELATIONSHIP OF Aß40 AND Aß42 DEPOSITION TO DURATION OF ILLNESS AND APOE GENOTYPE IN ALZHEIMERʼS DISEASE (1997) (0)
O2-02-08 Levels of autoantibodies to redox-modified abeta are attenuated in the plasma of Alzheimer's disease patients (2004) (0)
O2–01–02: Withdrawn (2013) (0)
Improved amyloid pathology contrasting with unexpected memory defects following astrocytic ApoE-e2 overexpression in hippocampus of Alzheimer’s mice (2015) (0)
Edinburgh Explorer Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease (2017) (0)
Pitfalls in the Diagnosis of Creutzfeldt-Jakob Disease: Caveat Emptor (1987) (0)
Partial reduction of microglia does not affect tau pathology in aged mice (2018) (0)
Short Communication Immunohistochemical Study of the b-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer’s Disease Brains (1998) (0)
P3-100 Longitudinal changes in plasma Aβ42 positively correlate with progression of mild cognitive impairment (2006) (0)
γ-Secretase conformational changes in the Alzheimer's Disease brain (2011) (0)
Chapter 11 Biomedical FRET–FLIM applications (2009) (0)
Subject Index Vol. 4, 2007 (2007) (0)
P1-387 Comparative analysis of heparan sulfate co-localization with Aβ40 and Aβ42 in different Aβ deposits of APP transgenic mice and Alzheimer’s disease patients (2006) (0)
P4-079 Coordinated expression of APP pathway mRNA and protein in AD (2006) (0)
TAU SPREADING AND TOXICITY (2016) (0)
Explorer Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer ¿ s disease (2016) (0)
Erratum: CSF biomarker variability in the Alzheimer's Association quality control program (Alzheimer's and Dementia (2013) 9 (251-261)) (2015) (0)
Different tau species lead to heterogeneous tau pathology propagation and misfolding (2018) (0)
O2-03-03 Modulation of neuronal activity results in altered APP processing and spatial alignment of PS1 and APP (2006) (0)
Projection in Proxy Assessments of Everyday Preferences for Persons with Cognitive Impairment (2022) (0)
Caspase cleavage of tau is critical for oligomeric beta-amyloid–induced sub-lethal apoptotic cascade (2013) (0)
RELEVANCE OF TAU SEEDING FOR THE CLINICAL HETEROGENEITY OF ALZHEIMER’S DISEASE: IMPLICATION FOR THERAPEUTIC PERSPECTIVES (2019) (0)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (0)
Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation (2023) (0)
Correction for Irizarry et al., Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse (1998) (0)
Genetic Overlap Between Immune-Mediated Diseases and Alzheimer’s Disease (S21.004) (2016) (0)
P3-205: Upregulation of genes in the Wnt pathway in tg-ArcSwe mice and Alzheimer's disease brain (2008) (0)
Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis (2019) (0)
Title Association between genetic traits for immune-mediated diseases and Alzheimer disease Permalink (2016) (0)
APOE4 plays a role in Abeta-mediated synapse loss in Alzheimer's disease (2011) (0)
P1-473: Aβ disrupts spinodendritic calcium regulation in vivo (2008) (0)
Neurofibrillary tangles remain functionally integrated in cortical networks (2013) (0)
Edinburgh Research Explorer Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model (2018) (0)
Beta-secretase (BACE) and GGA1 interaction in cells is dependent on BACE phosphorylation (2004) (0)
Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production (2017) (0)
Multiphoton Microscopy: Imaging Plaques and Reversal of Plaques — a Transgenic Model by Multiphoton Microscopy (2003) (0)
Explorer Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease (2016) (0)
NLRP1 INFLAMMASOME REGULATES CASPASE-1-MEDIATED CASPASE-6 ACTIVATION IN HUMAN NEURONS (2014) (0)
Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease (2023) (0)
TREM2 Limits Progression of Deficits and Spreading of Tau Pathology in Mice (2021) (0)
Cell Reports Resource The Major Risk Factors for Alzheimer ’ s Disease : Age , Sex , and Genes Modulate the Microglia Response to A b Plaques (2019) (0)
A unique high-molecular-weight tau species is involved in propagation and accumulates in the cerebrospinal fluid of Alzheimer’s disease patients (2015) (0)
Detection diagnostique de multiphotons in vivo et imagerie d'une maladie neurodegenerative (2001) (0)
Eloise Hudry of Amyloid Deposition and Neurotoxicity in Mouse Brain Isoforms Results in Differential Modulation Apoe Gene Transfer of Human (2013) (0)
P1-214 Demonstration of BACE phosphorylation and its interaction with GGA1 in cells by fluorescence lifetime imaging microscopy (FLIM) (2004) (0)
NEUROPATHOLOGICAL STUDIES IN MICE HETEROZYGOUS FOR THE DISRUPTED PRESENILIN-1 GENE (1998) (0)
Explorer Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg 4510 Model of Tauopathy (2017) (0)
Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts (2018) (0)
P4-154: Neuronal atrophy and neuropil loss, rather than neuronal loss, underlies age-related cortical brain atrophy in elderly subjects without Alzheimer's disease (2008) (0)
Cognitive functioning of two centenarians with left hippocampal lesions (1999) (0)
Activation de caspases et formationes neurofibrillaires dans un modèle murin de la maladie d'Alzheimer (2010) (0)
Duodenitis: A Preulcer State (2017) (0)
Contents Vol. 4, 2007 (2007) (0)
Alzheimer's-signature MRI biomarker predicts likelihood of Alzheimer's dementia in cognitively normal adults (2011) (0)
Modulators of expression and function of LRP in Alzheimer's disease (1997) (0)
Assessing the Clinical Meaningfulness of the Alzheimer’s Disease Composite Score (ADCOMS) Tool (2022) (0)
S2-02-05 Neuritic alterations and dysfunctions in Alzheimer’s disease (2006) (0)
A transgenic model of the earliest stage of Alzheimer's disease (2010) (0)
Tau Protein Disrupts Nucl eocytoplasmic Transport in Alzheimer ’ s Disease Graphical Abstract Highlights (2018) (0)
P3-268 Chip colocalizes with phosphorylated tau in neurofibrillary tangles in AD brain (2004) (0)
CALCIUM/CALMODULIN KINASE II IS COLOCALIZED WITH PAIRED HELICAL FILAMENTS (1993) (0)
P1-090 Observation of new senile plaque formation and associated neuritic abnormalities using multiphoton microscopy (2006) (0)
Probing the effect of Heat Shock Protein 70 on the aggregation of α-Synuclein (2009) (0)
UNRAVELING THE ROLE OF APOLIPOPROTEIN E IN AGE- AND ABETA-RELATED NEURONAL DYSFUNCTION (2014) (0)
Tau pathology vulnerable neuronal subpopulation in Alzheimer’s disease (2022) (0)
O1-03-01 Apolipoprotein E inhibits gamma-secretase cleavage of the amyloid precursor protein (2004) (0)
Tau seeding and spreading in vivo is supported by both fibrillar and oligomeric tau (2023) (0)
Up-regulation of LDL receptor-related protein expression in Alzheimer's disease and in vitro (2000) (0)
Explorer Soluble forms of tau are toxic in Alzheimer ' s disease (2017) (0)
Decoding Multiple Subject fMRI Data using Manifold based Representation of Cognitive State Neural Signatures (2020) (0)
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease (2023) (0)
Explorer Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer ' s disease (2017) (0)
Development and Evaluation of a Natural Language Processing Annotation Tool (NAT) to Facilitate Phenotyping of Cognitive Status in Electronic Health Records (2022) (0)
Modeling braak-like progression of tangles in the medial temporal lobe (2015) (0)
Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV (2014) (0)
Editorial Board (2007) (0)
Author response: Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle (2018) (0)
S.19.03 Exploring the early pathogenesis in Alzheimer's disease: insights from transgenic mouse models (2007) (0)
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease (2021) (0)
Investigating the binding of high molecular weight tau to LRP1 (2022) (0)
PHENOTYPIC CHARACTERIZATION OF PSI AND PS2 RELATED ALZHEIMERʼS DISEASE (1997) (0)
Mapping whole-brain activity with cellular resolution by light-sheet microscopy and high-throughput image analysis (Conference Presentation) (2016) (0)
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease (2022) (0)
Multiple Myeloma With Polyneuropathy and Coagulopathy-Reply (1986) (0)
Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease (2022) (0)
Edinburgh Research Explorer Opposing Roles of apolipoprotein E in aging and neurodegeneration (2019) (0)
P1-180: Reliability and predictive validity of questionnaire items for development of a brief, structured clinical dementia rating interview (2008) (0)
α-SYNUCLEIN IMMUNOREACTIVITY IN LEWY BODIES AND ABNORMAL NEURITES IN PARKINSONʼS DISEASE AND DEMENTIA WITH LEWY BODY BRAIN (1998) (0)
Reply (1997) (0)
Assessment of the interaction between presenilin 1 (PS1) and ubiquilin 1 splice variants in intact cells (2007) (0)
Book Review Neurobiology of Disease Edited by Alan L. Pearlman and Robert C. Collins. 482 pp., illustrated. New York, Oxford University Press, 1990. $55 (cloth); $34.95 (paper). Published in previous editions asNeurological pathophysiology. (1990) (0)
Explorer Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer ' s disease brain (2017) (0)
Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds (2020) (0)

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