Brett Giroir | Academic Influence

Brett Giroir's AcademicInfluence.com Rankings

Brett Giroir

Medical

#208

World Rank

#308

Historical Rank

Pediatrics

#38

World Rank

#48

Historical Rank

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Medical

Why Is Brett Giroir Influential?

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According to Wikipedia, Brett P. Giroir is an American pediatrician. He was formerly the U.S. assistant secretary for health, a four-star admiral in the U.S. Public Health Service Commissioned Corps and an acting Food and Drug Administration commissioner.

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Brett Giroir's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics* (2005) (2938)
Ending the HIV Epidemic: A Plan for the United States. (2019) (767)
Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. (1998) (567)
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial (2007) (401)
Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial (2000) (390)
Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine (1992) (333)
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia. (1992) (253)
Pathophysiology, treatment and outcome of meningococcemia: a review and recent experience. (1996) (238)
Cell lines derived from avian lymphomas exhibit two distinct phenotypes. (1985) (221)
Pediatric critical care medicine: Planning for our research future (2003) (193)
Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. (1996) (186)
Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis (1997) (168)
Mediators of septic shock: New approaches for interrupting the endogenous inflammatory cascade (1993) (152)
Inhibition of tumor necrosis factor prevents myocardial dysfunction during burn shock. (1994) (137)
Fresh whole blood versus reconstituted blood for pump priming in heart surgery in infants. (2004) (136)
Magnetic Resonance Imaging and Invasive Evaluation of Development of Heart Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α (1999) (132)
The Pediatric Multiple Organ Dysfunction Score (P-MODS): Development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children* (2005) (131)
A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome. (1993) (118)
Racial/Ethnic and Age Group Differences in Opioid and Synthetic Opioid–Involved Overdose Deaths Among Adults Aged ≥18 Years in Metropolitan Areas — United States, 2015–2017 (2019) (116)
Tumor necrosis factor-α-induced caspase activation mediates endotoxin-related cardiac dysfunction* (2005) (106)
Pharmacokinetics and pharmacodynamics of milrinone lactate in pediatric patients with septic shock. (1998) (105)
Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis. (2004) (103)
Preoperative and postoperative endotoxemia in children with congenital heart disease. (2000) (100)
Factor-Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis (1998) (99)
Cytokine-induced expression of nitric oxide synthase in C2C12 skeletal muscle myocytes. (1994) (95)
Constitutive synthesis of tumor necrosis factor in the thymus. (1992) (95)
Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor. (2003) (91)
Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-kappaB activation and cardiomyocyte cytokine secretion. (2001) (87)
IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. (2003) (79)
Analysis of Drug Test Results Before and After the US Declaration of a National Emergency Concerning the COVID-19 Outbreak. (2020) (75)
Overexpression of cardiac I-κBα prevents endotoxin-induced myocardial dysfunction (2001) (72)
Bactericidal/permeability-increasing protein—Lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia (2001) (69)
Expression of the inducible nitric oxide synthase gene in diaphragm and skeletal muscle. (1996) (63)
Molecular biology of septic shock. (1998) (63)
Obesity, macrophage migration inhibitory factor, and weight loss (2005) (61)
ENHANCE: Results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis* (2006) (61)
Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. (1999) (59)
Randomized, placebo-controlled, double blinded trial of dexamethasone in African children with sepsis. (1996) (56)
Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury. (2005) (53)
Effect of amrinone on tumor necrosis factor production in endotoxic shock. (1992) (53)
Patient-Centered Reduction or Discontinuation of Long-term Opioid Analgesics: The HHS Guide for Clinicians. (2019) (50)
Myocardial inflammatory activation in children with congenital heart disease (2002) (49)
The biosynthesis of tumor necrosis factor during pregnancy: studies with a CAT reporter transgene and TNF inhibitors. (1992) (41)
The Time Is Now to End the HIV Epidemic. (2019) (40)
Naloxone Co-prescribing to Patients Receiving Prescription Opioids in the Medicare Part D Program, United States, 2016-2017. (2019) (39)
Differential Regulation of Myocardial NF κ B Following Acute or Chronic TNF- α Exposure (2001) (38)
Development of an acute burn model in adult mice for studies of cardiac function and cardiomyocyte cellular function. (2001) (36)
Aspiration pneumonia-induced sepsis increases cardiac dysfunction after burn trauma. (1998) (35)
Calcium antagonists improve cardiac mechanical performance after thermal trauma. (1999) (34)
Overexpression of cardiac I-kappaBalpha prevents endotoxin-induced myocardial dysfunction. (2001) (33)
IκB overexpression in cardiomyocytes prevents NF-κB translocation and provides cardioprotection in trauma (2003) (32)
Physical Activity Guidelines for Health and Prosperity in the United States (2018) (32)
Thermal injury alters myocardial sarcoplasmic reticulum calcium channel function. (1999) (31)
The systemic inflammatory response syndrome (SIRS): Immunology and potential immunotherapy (1993) (31)
Burn plasma mediates cardiac myocyte apoptosis via endotoxin. (2001) (30)
Differential regulation of myocardial NF kappa B following acute or chronic TNF-alpha exposure. (2001) (29)
Regulation of cytokine gene expression: tumor necrosis factor, interleukin-1, and the emerging biology of cytokine receptors. (1995) (27)
BURN PLASMA MEDIATES CARDIAC MYOCYTE APOPTOSIS VIA ENDOTOXIN: 96 (2001) (26)
Human coronary endothelial cell activation by endotoxin is characterized by NF-κB activation and TNF-α synthesis (2001) (25)
Recombinant human activated protein C for the treatment of severe sepsis: is there a role in pediatrics? (2003) (25)
Reply: Values for Systolic Blood Pressure (2005) (21)
Genetic sequences and transcriptional regulation of the TNFA promoter: comparison of human and baboon (1998) (21)
Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-alpha transgenic mice. (2001) (19)
Reforming the Veterans Health Administration--Beyond Palliation of Symptoms. (2015) (16)
Pancreatitis, cytokines, and SIRS: déjà vu all over again? (1999) (15)
Myocardial depression versus myocardial destruction: integrating the multiple mechanisms of myocardial dysfunction during sepsis. (2000) (15)
I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma. (2003) (14)
Erratum: IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction (American Journal of Physiology Heart and Circulatory Physiology (August 2003) 285 (H597-H606)) (2004) (14)
230; INDUCTION OF NITRIC OXIDE SYNTHASE (iNOS) IN SKELETAL MUSCLE (1994) (13)
Molecular and pharmacological approaches to inhibiting nitric oxide after burn trauma. (2003) (11)
Opioid Prescribing Trends and the Physician's Role in Responding to the Public Health Crisis. (2019) (11)
Human coronary endothelial cell activation by endotoxin is characterized by NF-kappa B activation and TNF-alpha synthesis. (2001) (10)
Effects of transforming growth factor-beta 1 on nitric oxide synthesis by C2C12 skeletal myocytes. (1996) (10)
The fine specificity of immune suppression to individual nucleosides. (1981) (10)
Clinical expert round table discussion (session 5) at the Margaux Conference on Critical Illness: outcomes of clinical trials in sepsis: lessons learned. (2001) (10)
Improving the outcome of septic shock in children. (2000) (9)
Meningococcemia as a model for testing the hypothesis of antisepsis therapies (2000) (7)
Nucleoside-specific suppression in MRL/MP +/+ mice. (1983) (6)
THE EFFICACY OF DROTRECOGIN ALFA (ACTIVATED) FOR THE TREATMENT OF PEDIATRIC SEVERE SEPSIS.: 166-T (2005) (6)
Healthy People 2030: A Call to Action to Lead America to Healthier Lives (2020) (6)
Complementary DNA (cDNA) sequence of baboon tumor necrosis factor alpha. (1997) (5)
The State of Sickle Cell Disease Care in the United States: How Can Emergency Medicine Contribute? (2020) (5)
Sequence Analysis of the Tumor Necrosis Factor Gene in Pediatric Patients with Autoimmunity (1995) (5)
Neonatal Abstinence Syndrome: Leveraging Health Information Technology to Develop a Data-Driven National Policy Approach (2020) (5)
Usefulness of external counterpulsation early postoperatively after the Fontan procedure in children. (2002) (5)
A pilot pharmacokinetic study of tricyclic antidepressant ovine Fab for TCA poisoning in children (2010) (4)
Process-driven selection of information systems for healthcare (1995) (3)
NFB ACTIVATION IN MOUSE HEART AFTER LPS AND/OR TNFα STIMULATION (1999) (3)
The Trump Administration's Actions to Address the Opioid Public Health Crisis. (2019) (3)
Bronchocentric granulomatosis in a nonasthmatic adolescent. (1989) (3)
PHARMACOKINETICS AND PHARMACODYNAMICS OF MILRINONE LACTATE IN PEDIATRIC PATIENTS WITH SEPTIC SHOCK. † 288 (1996) (2)
TIMING THERAPY FOR MENINGOCOCCAL INFECTION (1997) (2)
Bactericidal/permeability-increasing protein: clinical development and potential pediatric applications. (2001) (2)
Bactericidal/Permeability-Increasing Protein (BPI): Structure, Function, and Clinical Applications (1998) (2)
Introduction to the Second Margaux Conference on Critical Illness Sepsis: Interface Between Inflammation, Coagulation, and the Endothelium (2001) (2)
Reply: Definitions of Pediatric Septic Shock (2005) (1)
Bactericidal/permeability-increasing protein for severe meningococcal sepsis (1998) (1)
H-2-determined kinetic differences for the induction of nucleoside-specific suppression. (1983) (1)
Chapter 83 – The Innate Immune System (2006) (1)
THE CELLULAR BASIS FOR ENDOTOXIN-INDUCED CARDIAC DYSFUNCTION IN GUINEA PIGS.• 248 (1996) (0)
EFFECTS OF IL‐4 ON NITRIC OXIDE PRODUCTION BY HUMAN MONOCYTES.: 34 (1995) (0)
MATRIX METALLOPROTEINASES (MMP'S) MEDIATE CARDIAC DYSFUNCTION DURING ENDOTOXEMIA: 322 (2004) (0)
Phase I/II Trial of rBPI-21 (a Recombinant 21kD Fragment of Bactericidal/Permeability-Increasing Protein) in Children with Severe Meningococcemia. † 196 (1997) (0)
New therapies for severe meningococcal disease (1998) (0)
MATRIX METALLOPROTEINASES MEDIATE CARDIAC DYSFUNCTION FOLLOWING THERMAL TRAUMA: 12 (2004) (0)
CHANGES IN MARKERS OF COAGULATION AND INFLAMMATION IN PATIENTS WITH PEDIATRIC SEVERE SEPSIS TREATED WITH DROTRECOGIN ALFA (ACTIVATED).: 169-T (2005) (0)
ENDOTOXIN INDUCES TNF‐&agr; DEPENDENT APOPTOSIS IN THE HEART: 101 (2001) (0)
Septic Shock in Children: When Should Prevention Start and Treatment End? (2020) (0)
CARDIAC DYSFUNCTION IN BURNED RATS WITH APSPIRATION PNEUMONIA-INDUCED SEPSIS (1998) (0)
A MURINE MODEL OF BURN TRAUMA (1999) (0)
Phase I/II Trial of rBPI‐21 (a Recombinant 21kD Fragment of Bactericidal/Permeability‐Increasing Protein) in Children with Severe Meningococcemia.: 567 (1997) (0)
Heparin in sepsis treatment – Authors' reply (2007) (0)
DETECTION AND SIGNIFICANCE OF ENDOTOXIN IN CHILDREN FOLLOWING CARDIOPULMONARY BYPASS (1999) (0)
A Transgenic Model of TNF‐&agr; Production in the Myocardium.: 349 (1997) (0)
A Trangenic Model of TNF-α Production in the Myocardium ♦ 184 (1997) (0)
COMPARISON OF HUMAN AND BABOON TNF&agr; ‐ GENETIC SEQUENCES AND TRANSCRIPTIONAL REGULATON.: 37 (1998) (0)
THE IDENTIFICATION OF ANTI‐APOPTOTIC FACTORS IN NF‐&kgr;B MEDIATED APOPTOSIS INHIBITION IN THE HEART.: 280 (2003) (0)
DIMINISHED EXPRESSION OF THE CARDIAC CALCIUM EFFLUX CHANNEL mRNA DURING ENDOTOXIC SHOCK IN GUINEA PIGS.: 22 (1995) (0)
Expression of the inducible nitric oxide synthase gene in (2015) (0)
IL‐4 AND IL‐10 AUGMENT CYTOKINE‐INDUCED NITRIC OXIDE (NO) SYNTHESIS BY SKELETAL MYOCYTES.: 43 (1995) (0)
TIMING THERAPY FOR MENINGOCOCCAL INFECTION. AUTHORS' REPLY (1997) (0)
ROLE OF ICAM-1 IN A TRANSGENIC MODEL OF TNF??-INDUCED HEART FAILURE (1999) (0)
NF‐KB DEPENDENT GENES PROTECT AGAINST CARDIAC MYOCYTE APOPTOSIS DURING ENDOTOXEMIA: 181 (2004) (0)
79 ENDOTOXIN-INDUCED CHANGES IN MYOCYTE GENE EXPRESSION (1995) (0)
ENDOTOXIN INDUCES TNF-α DEPENDENT APOPTOSIS IN THE HEART: 101 (2001) (0)
MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) MEDIATES LATE CARDIAC DYSFUNCTION FOLLOWING THERMAL INJURY: 320 (2004) (0)
NEW THERAPIES FOR SEVERE MENINGOCOCCAL DISEASE. AUTHORS' REPLY (1998) (0)
What Are the Specific Definitions of Pediatric SIRS , Infection , Sepsis , Severe Sepsis , and Septic Shock ? (2005) (0)
Method of treatment and bioassay involving inhibition factor macrophage migration (MIF) as myocardial depressant factor cardiac (2004) (0)
THE ROLE OF ENDOTOXIN AND TNFα IN THE PATHOGENESIS OF CARDIAC DYSFUNCTION: 98 (1999) (0)
Altered calcium (Ca2+) mobilization after burn trauma: Beneficial effects of calcium antagonist dantrolene (1997) (0)
THE ROLE OF NFκB TRANSLOCATION IN EXPERIMENTAL MYOCARDIAL DYSFUNCTION: 99 (1999) (0)
MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) IS A NOVEL CARDIAC‐DERVIED MYOCARDIAL DRESSANT: 4 (2002) (0)
THE ROLE OF NITRIC OXIDE IN CARDIAC MYOCYTE APOPTOSIS INDUCED BY BURN PLASMA: 212 (2002) (0)
EXPRESSION OF INDUCIBLE NITRIC OXIDE SYTHASE (iNOS) IN DIAPHRAGM AND SKELETAL MUSCLE DURING MURINE ENDOTOXEMIA.: 42 (1995) (0)
Inhibition of myocardial NFκB activation reduces cardiac dysfunction following LPS challenge in transgenic mice (1999) (0)
MYOCARDIAL NFKB IS RAPIDLY ACTIVATED FOLLOWING LPS OR TNFA CHALLENGE (1999) (0)
Macrophage Migration Inhibitory Factor (MIF) & Weight Loss (2004) (0)
MYOCYTE INTRACELLULAR CALCIUM IS INCREASED IN MYOCARDIAL DEPRESSION CAUSED BY BURN INJURY.: 81 (1996) (0)
therapeutic uses of bactericidal / Enhancers protein products of permeability (IPGs) for human meningococcemia. (1997) (0)
In Search of Novel Therapies for Pediatric Sepsis: Biology, Feasibility, and Ethical Considerations.: 557 (1997) (0)
THE SAFETY OF DROTRECOGIN ALFA (ACTIVATED) IN PEDIATRIC PATIENTS WITH SEVERE SEPSIS.: 168-T (2005) (0)
CARDIAC RELEASE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) FOLLOWING LPS CHALLENGE IS TNF DEPENDENT.: 321 (2004) (0)
A Transgenic Model of TNF-α Production in the Myocardium.: 349 (1997) (0)
Nucleic acid specific suppression in mrl/mp +/+ mice. Abstr. (1982) (0)
The Effects of Cytokines on Intracellular Calcium in Isolated, Adult Guinea Pig Myocytes. † 197 (1997) (0)
The authors reply: academic and industry partnerships. (2006) (0)

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