Brian Kobilka

Q: What Schools Are Affiliated With Brian Kobilka

Brian Kobilka is affiliated with the following schools: University of Minnesota, Tsinghua University, Stanford University, Case Western Reserve University, University of Minnesota Duluth, Duke University

Brian Kobilka's AcademicInfluence.com Rankings

Brian Kobilka

Biology

#193

World Rank

#354

Historical Rank

#111

USA Rank

Physiology

World Rank

#36

Historical Rank

USA Rank

biology Degrees

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Biology

Why Is Brian Kobilka Influential?

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According to Wikipedia, Brian Kent Kobilka is an American physiologist and a recipient of the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for discoveries that reveal the workings of G protein-coupled receptors. He is currently a professor in the department of Molecular and Cellular Physiology at Stanford University School of Medicine. He is also a co-founder of ConfometRx, a biotechnology company focusing on G protein-coupled receptors. He was named a member of the National Academy of Sciences in 2011.

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Brian Kobilka's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Crystal Structure of the β2Adrenergic Receptor-Gs protein complex (2011) (2589)
High-Resolution Crystal Structure of an Engineered Human β2-Adrenergic G Protein–Coupled Receptor (2007) (2350)
Crystal structure of the human β2 adrenergic G-protein-coupled receptor (2007) (1579)
Structure of a nanobody-stabilized active state of the β2 adrenoceptor (2010) (1516)
The structure and function of G-protein-coupled receptors (2009) (1317)
GPCR Engineering Yields High-Resolution Structural Insights into β2-Adrenergic Receptor Function (2007) (1312)
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist (2012) (1249)
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin (1986) (1137)
Functional Selectivity and Classical Concepts of Quantitative Pharmacology (2007) (1078)
Activation and allosteric modulation of a muscarinic acetylcholine receptor (2013) (773)
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. (2007) (768)
βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance (2002) (765)
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist (2011) (763)
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice (1995) (728)
Structure and Function of an Irreversible Agonist-β2 Adrenoceptor complex (2010) (720)
Structure and Dynamics of the M3 Muscarinic Acetylcholine Receptor (2012) (716)
Conformational complexity of G-protein-coupled receptors. (2007) (679)
The Dynamic Process of β2-Adrenergic Receptor Activation (2013) (677)
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein (2007) (672)
Structure-based discovery of opioid analgesics with reduced side effects (2016) (671)
Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. (1988) (670)
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. (1987) (662)
Structural insights into μ-opioid receptor activation (2015) (653)
Structure of the δ-opioid receptor bound to naltrindole (2012) (603)
G protein coupled receptor structure and activation. (2007) (584)
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor (1988) (574)
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. (1987) (569)
The Molecular Basis of G Protein-Coupled Receptor Activation. (2018) (541)
Structure and dynamics of GPCR signaling complexes (2017) (510)
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission (1999) (505)
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. (1988) (500)
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. (2007) (500)
A general protocol for the generation of Nanobodies for structural biology (2014) (491)
Cloning of the cDNA for the human beta 1-adrenergic receptor. (1987) (488)
Cardiovascular Regulation in Mice Lacking α2-Adrenergic Receptor Subtypes b and c (1996) (482)
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. (2001) (475)
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins (1987) (472)
Ligand-specific regulation of the extracellular surface of a G protein coupled receptor (2009) (453)
G Protein-coupled Receptors (1998) (442)
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. (2003) (428)
Visualization of arrestin recruitment by a G Protein-Coupled Receptor (2014) (421)
Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. (1992) (420)
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization (1988) (419)
Structure of the μ Opioid Receptor-Gi Protein Complex (2018) (416)
Cryo-EM structure of the activated GLP-1 receptor in complex with G protein (2017) (402)
Phase-plate cryo-EM structure of a class B GPCR-G protein complex (2017) (400)
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. (1988) (397)
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins (2010) (396)
Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling (2015) (391)
Adrenaline-activated structure of the β2-adrenoceptor stabilized by an engineered nanobody (2013) (368)
Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide (2013) (367)
Agonists induce conformational changes in transmembrane domains III and VI of the β2 adrenoceptor (1997) (364)
Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. (1999) (363)
Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor* (2001) (355)
Counting Low-Copy Number Proteins in a Single Cell (2007) (351)
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor (2011) (349)
Coupling ligand structure to specific conformational switches in the β2-adrenoceptor (2006) (341)
Targeted Disruption of the β2 Adrenergic Receptor Gene* (1999) (337)
ERK Plays a Regulatory Role in Induction of LTP by Theta Frequency Stimulation and Its Modulation by β-Adrenergic Receptors (1999) (335)
Adrenergic receptors as models for G protein-coupled receptors. (1992) (329)
Agonist-induced conformational changes in the G-protein-coupling domain of the β2 adrenergic receptor (2001) (319)
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology. (2000) (309)
Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. (1996) (307)
Gene targeting — homing in on α2-adrenoceptor-subtype function (1997) (304)
Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. (1992) (303)
Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. (2004) (299)
Muscarinic acetylcholine receptors: novel opportunities for drug development (2014) (298)
Structural Instability of a Constitutively Active G Protein-coupled Receptor (1997) (280)
High-resolution crystal structure of human Protease-Activated Receptor 1 bound to the antagonist vorapaxar (2012) (267)
Structure-based drug screening for G-protein-coupled receptors. (2012) (264)
Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists* (2005) (264)
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex (2019) (263)
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function. (2010) (253)
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors (2016) (253)
Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide. (1992) (251)
Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors* (1999) (251)
Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. (1990) (250)
Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes* (2002) (244)
Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. (1989) (243)
Structure-based discovery of β2-adrenergic receptor ligands (2009) (243)
Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. (1994) (240)
Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. (1997) (237)
Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. (1997) (236)
Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes. (1995) (234)
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis. (1994) (223)
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex (2009) (222)
Myocyte Adrenoceptor Signaling Pathways (2003) (222)
New G-protein-coupled receptor crystal structures: insights and limitations. (2008) (221)
Nanobody stabilization of G protein-coupled receptor conformational states. (2011) (220)
Allosteric regulation of G protein-coupled receptor activity by phospholipids. (2016) (217)
Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. (1987) (216)
Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling (2015) (213)
Structural basis for nucleotide exchange in heterotrimeric G proteins (2015) (212)
Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. (1993) (209)
Propagation of conformational changes during μ-opioid receptor activation (2015) (205)
High-resolution crystal structure of human protease-activated receptor 1 (2012) (203)
Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac disease. (1997) (202)
The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin. (2014) (202)
Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation (2016) (200)
A new era of GPCR structural and chemical biology. (2012) (199)
Allosteric coupling from G protein to the agonist binding pocket in GPCRs (2016) (198)
Single-molecule analysis of ligand efficacy in β2AR-G protein activation (2017) (197)
Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization. (1994) (194)
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes (2019) (187)
Adrenergic α2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice (1998) (185)
β-Adrenergic Receptor Subtype-Specific Signaling in Cardiac Myocytes from β1 and β2 Adrenoceptor Knockout Mice (2001) (184)
Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine (2002) (183)
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer (2009) (178)
Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1 (2020) (177)
Subtype-Specific Intracellular Trafficking of α2-Adrenergic Receptors (1997) (171)
Structural flexibility of the Gαs α-helical domain in the β2-adrenoceptor Gs complex (2011) (170)
Nanobodies to Study G Protein-Coupled Receptor Structure and Function. (2017) (166)
Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor. (1995) (165)
Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. (1992) (165)
Skeletal muscle hypertrophy and anti‐atrophy effects of clenbuterol are mediated by the β2‐adrenergic receptor (2002) (159)
The role of ligands on the equilibria between functional states of a G protein-coupled receptor. (2013) (157)
Structural insights into adrenergic receptor function and pharmacology. (2011) (156)
Subtype-specific differences in the intracellular sorting of G protein-coupled receptors. (1993) (155)
Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist (1997) (154)
Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies. (2007) (144)
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4 (2008) (143)
Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations (2019) (141)
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor (2012) (141)
Conformational transitions of a neurotensin receptor 1–Gi1 protein complex (2019) (139)
Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2B Adrenoceptors (2000) (139)
A monoclonal antibody for G protein–coupled receptor crystallography (2007) (139)
Structure of the mu-opioid receptor-Giprotein complex. (2018) (138)
Goniometer-based femtosecond crystallography with X-ray free electron lasers (2014) (136)
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice (1996) (134)
Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors. (1992) (130)
GPCR–Gα fusion proteins: molecular analysis of receptor–G-protein coupling (1999) (128)
Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. (1995) (128)
A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists. (1991) (128)
The structural basis of G-protein-coupled receptor signaling (Nobel Lecture). (2013) (128)
Assembly of a GPCR-G Protein Complex (2019) (127)
Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. (2005) (127)
β2-Adrenergic Receptor-induced p38 MAPK Activation Is Mediated by Protein Kinase A Rather than by Gi or Gβγ in Adult Mouse Cardiomyocytes* (2000) (126)
Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. (1998) (125)
N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor (2012) (125)
Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure (2017) (123)
Gene targeting--homing in on alpha 2-adrenoceptor-subtype function. (1997) (123)
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox (2003) (122)
Transmembrane Regions V and VI of the Human Luteinizing Hormone Receptor Are Required for Constitutive Activation by a Mutation in the Third Intracellular Loop* (1996) (122)
Adrenergic receptor signal transduction and regulation (1995) (121)
Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels (1999) (120)
Isoflurane and Nociception: Spinal &agr;2A Adrenoceptors Mediate Antinociception while Supraspinal &agr;1 Adrenoceptors Mediate Pronociception (2002) (119)
Role of the α2B-Adrenergic Receptor in the Development of Salt-Induced Hypertension (1999) (117)
High resolution crystal structure of human B2-adrenergic G protein-coupled receptor. (2007) (117)
The PDZ Binding Motif of the β1 Adrenergic Receptor Modulates Receptor Trafficking and Signaling in Cardiac Myocytes* (2002) (116)
Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies (2014) (113)
Development of an antibody fragment that stabilizes GPCR/G-protein complexes (2018) (113)
Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5 (2017) (112)
Dosage‐dependent switch from G protein‐coupled to G protein‐independent signaling by a GPCR (2007) (111)
Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. (2014) (110)
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (2018) (109)
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations. (2001) (109)
The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation. (2000) (107)
Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations. (1999) (107)
Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape (2015) (106)
Conformational transitions of a neurotensin receptor 1–Gi1 complex (2019) (105)
Protecting the myocardium: A role for the &bgr;2 adrenergic receptor in the heart (2004) (105)
A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. (2012) (105)
Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors. (2001) (104)
Activation of the Luteinizing Hormone Receptor Following Substitution of Ser-277 with Selective Hydrophobic Residues in the Ectodomain Hinge Region* (2000) (104)
Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. (1987) (104)
G protein-coupled receptors: functional and mechanistic insights through altered gene expression. (1998) (103)
Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket (2017) (103)
Behavioral and neurochemical characterization of α2A-adrenergic receptor knockout mice (2002) (101)
Conformational dynamics of single G protein-coupled receptors in solution. (2011) (99)
A fluorescent probe designed for studying protein conformational change. (2005) (99)
Structural Insights into Metabotropic Glutamate Receptor Activation (2018) (98)
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice. (2002) (98)
Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. (2005) (96)
Activation of G protein-coupled receptors. (2007) (95)
Reconstitution of β2-adrenoceptor−GTP-binding-protein interaction in Sf9 cells (1998) (95)
reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. (2016) (94)
Single-molecule spectroscopy of the β2 adrenergic receptor: Observation of conformational substates in a membrane protein (2001) (94)
Structural insights into G-protein-coupled receptor activation. (2008) (93)
The PDZ-binding motif of the β2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes (2003) (93)
Allosteric Modulation of β2-Adrenergic Receptor by Zn2+ (2002) (92)
Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. (2001) (92)
Signaling from {beta}1- and {beta}2-adrenergic receptors is defined by differential interactions with PDE4 (2008) (90)
Organization of β-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes (2007) (90)
Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs. (2019) (88)
Diverse GPCRs exhibit conserved water networks for stabilization and activation (2019) (88)
In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures (2016) (88)
Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor. (2012) (88)
Structural Insights into the Process of GPCR-G Protein Complex Formation (2019) (87)
Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes. (2005) (87)
Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor* (2012) (85)
Co-expression of Defective Luteinizing Hormone Receptor Fragments Partially Reconstitutes Ligand-induced Signal Generation* (1997) (84)
Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor* (2003) (82)
Tandem facial amphiphiles for membrane protein stabilization. (2010) (82)
Structural insights into the activation of metabotropic glutamate receptors (2019) (81)
d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the α 2C-adrenergic receptor subtype (1998) (80)
Covalent agonists for studying G protein-coupled receptor activation (2014) (79)
A Novel Interaction between Adrenergic Receptors and the α-Subunit of Eukaryotic Initiation Factor 2B* (1997) (76)
Insights from in vivo modification of adrenergic receptor gene expression. (1998) (74)
Subtype-specific intracellular trafficking of alpha2-adrenergic receptors. (1997) (72)
Crystal structure of the natural anion-conducting channelrhodopsin GtACR1 (2018) (69)
Arrangement of Transmembrane Domains in Adrenergic Receptors (1996) (69)
The Ectodomain of the Luteinizing Hormone Receptor Interacts with Exoloop 2 to Constrain the Transmembrane Region (2002) (68)
Alterations in dynamic heart rate control in the β1-adrenergic receptor knockout mouse. (1998) (68)
Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. (1988) (68)
Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. (2013) (68)
Identification of intramolecular interactions in adrenergic receptors. (1992) (66)
Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM (2015) (66)
Amino acid substitutions at position 312 in the seventh hydrophobic segment of the beta 2-adrenergic receptor modify ligand-binding specificity. (1993) (65)
Heterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists (2002) (63)
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling (2020) (63)
Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery (2013) (62)
Structural insights into differences in G protein activation by family A and family B GPCRs (2020) (62)
High-density grids for efficient data collection from multiple crystals (2016) (62)
Spontaneous Activation of β2- but Not β1-Adrenoceptors Expressed in Cardiac Myocytes from β1β2 Double Knockout Mice (2000) (61)
Development and Characterization of Pepducins as Gs-biased Allosteric Agonists*♦ (2014) (61)
Using synthetic lipids to stabilize purified beta2 adrenoceptor in detergent micelles. (2005) (61)
A genetically engineered cell-based biosensor for functional classification of agents. (2001) (60)
Structural mechanisms of selectivity and gating in anion channelrhodopsins (2018) (59)
Erratum: Culture and adenoviral infection of adult mouse cardiac myocytes: Methods for cellular genetic physiology (American Journal of Physiology - Heart and Circulatory Physiology (July 2000) 279:48 (H429-H436)) (2000) (59)
Derivation of functional antagonists using N-terminal extracellular domain of gonadotropin and thyrotropin receptors. (1997) (59)
Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor. (2004) (56)
Sequential Binding of Agonists to the β2 Adrenoceptor (2004) (55)
Alpha2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies. (1998) (53)
Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns (1999) (53)
Gene Substitution/Knockout to Delineate the Role of α2‐Adrenoceptor Subtypes in Mediating Central Effects of Catecholamines and Imidazolines (1999) (53)
Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry (2015) (52)
Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes (2014) (52)
Agonist binding: a multistep process. (2004) (51)
Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists (2018) (51)
Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. (1997) (51)
Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies. (2016) (50)
Cell-type Specific Targeting of the α2c-Adrenoceptor (2000) (50)
An improved yeast surface display platform for the screening of nanobody immune libraries (2019) (49)
Agonist-induced conformational changes in the beta2 adrenergic receptor. (2002) (48)
Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy. (2019) (48)
Mechanism of β2AR regulation by an intracellular positive allosteric modulator (2019) (47)
Analysis of biomolecular interactions using a miniaturized surface plasmon resonance sensor. (2002) (47)
G-protein activation by a metabotropic glutamate receptor (2021) (47)
Shared decision-making drives collective movement in wild baboons (47)
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor (2018) (46)
Functional Immobilization of a Ligand‐Activated G‐Protein‐Coupled Receptor (2002) (46)
Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development. (2014) (44)
Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor (2018) (44)
Adrenergic Receptors From Molecular Structure to in vivo function. (1997) (43)
Phospholipid biotinylation of polydimethylsiloxane (PDMS) for protein immobilization. (2006) (43)
Local membrane charge regulates β2 adrenergic receptor coupling to Gi3 (2019) (42)
Regulation of G‐Protein Coupled Receptor Traffic by an Evolutionary Conserved Hydrophobic Signal (2010) (42)
Effect of targeted deletions of β1- and β2-adrenergic-receptor subtypes on heart rate variability (2006) (41)
Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. (2003) (41)
Behavioral and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice. (2002) (41)
The role of cytosolic and membrane factors in processing of the human beta-2 adrenergic receptor following translocation and glycosylation in a cell-free system. (1990) (39)
The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor. (2003) (37)
Cloning and expression of the mouse homolog of the human α2-C2 adrenergic receptor (1992) (37)
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor (2020) (36)
Novel tripod amphiphiles for membrane protein analysis. (2013) (36)
Toward understanding GPCR dimers (2004) (35)
Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties. (2017) (35)
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist (2020) (35)
Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. (1990) (35)
International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached? (2010) (35)
Ligand stabilization of the beta 2 adrenergic receptor: effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy. (1996) (34)
Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine (2020) (33)
Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR (2020) (33)
The new biology of drug receptors. (1989) (33)
β-Adrenergic receptors and rhodopsin: shedding new light on an old subject (1986) (32)
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor (2020) (32)
Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension. (1999) (32)
Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation. (2016) (31)
Genetic models of human vascular disease. (1995) (31)
Restricting mobility of Gsalpha relative to the beta2-adrenoceptor enhances adenylate cyclase activity by reducing Gsalpha GTPase activity. (1998) (30)
Differential targeting and function of α2A and α2C adrenergic receptor subtypes in cultured sympathetic neurons (2006) (30)
Analysis of β2AR-Gs and β2AR-Gi complex formation by NMR spectroscopy (2020) (30)
Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor. (2002) (30)
Molecular biology of adrenergic receptors. (1988) (30)
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex (2020) (29)
Allosteric modulation of beta2-adrenergic receptor by Zn(2+). (2002) (29)
Crystal structure of the human b 2 adrenergic G-protein-coupled receptor (2007) (29)
The Structural Basis of G‐Protein‐Coupled Receptor Signaling (Nobel Lecture). (2013) (28)
GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling. (1999) (28)
Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach (2013) (28)
Human β 1- and β 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes (1988) (27)
Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability. (2006) (27)
The cubicon method for concentrating membrane proteins in the cubic mesophase (2017) (27)
Examining the efficiency of receptor/G‐protein coupling with a cleavable β2‐adrenoceptor–Gsα fusion protein (1999) (27)
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling (1998) (27)
Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. (2019) (26)
N-Ethylmaleimide-Sensitive Factor Regulates β2 Adrenoceptor Trafficking and Signaling in Cardiomyocytes (2007) (26)
Irreversible Agonist-Beta2 Adrenoceptor Complex (2011) (25)
Uncovering patterns of atomic interactions in static and dynamic structures of proteins (2019) (24)
Alterations in dynamic heart rate control in the beta 1-adrenergic receptor knockout mouse. (1998) (24)
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide (2021) (24)
Vadim Cherezov Coupled Receptor −-Adrenergic G Protein 2 β High-Resolution Crystal Structure of an Engineered Human (2012) (23)
Structural insights into the activation of metabotropic glutamate receptors (2019) (22)
Allosteric activation of the CaR by L-amino acids. (2000) (21)
The developmental and physiological consequences of disrupting genes encoding beta 1 and beta 2 adrenoceptors. (1998) (21)
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation (2022) (21)
Cherezov ,-Adrenergic G Protein Coupled Receptor 2 Human 2 High-Resolution Crystal Structure of an Engineered (2008) (20)
Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist (2021) (20)
Differential Distribution of-Adrenergic Receptor Subtypes in Blood Vessels of Knockout Mice Lacking 1-or 2-Adrenergic Receptors (2001) (20)
Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor (2018) (19)
Novel Insights into M3 Muscarinic Acetylcholine Receptor Physiology and Structure (2014) (19)
EVIDENCE FOR THE ORGANIZATION OF RECEPTOR MICRODOMAINS DURING NEURONAL DIFFERENTIATION OF PC12 CELLS (2000) (19)
Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability. (2017) (19)
Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02560f (2018) (18)
Cell-type specific targeting of the alpha 2c-adrenoceptor. Evidence for the organization of receptor microdomains during neuronal differentiation of PC12 cells. (2000) (18)
Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice. (2000) (18)
Viewing rare conformations of the β2 adrenergic receptor with pressure-resolved DEER spectroscopy (2020) (18)
Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery. (2009) (18)
Structure of the µ-opioid receptor–Gi protein complex (2018) (17)
Structure of the M3 Muscarinic Acetylcholine Receptor (2012) (16)
A medium for the maintenance of Chironomus tentans salivary glands in vitro (1979) (16)
The Effect of pH on β2 Adrenoceptor Function (2000) (15)
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. (2021) (15)
Restricting the mobility of Gs alpha: impact on receptor and effector coupling. (1999) (15)
Selective modulation of the cannabinoid type 1 (CB1) receptor as an emerging platform for the treatment of neuropathic pain. (2019) (15)
1 Structural and Functional Analysis of a β 2-Adrenergic Receptor Complex with GRK 5 (2018) (14)
Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03700g (2017) (14)
Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy. (2016) (14)
Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation. (2015) (14)
Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs. (2018) (14)
Structural insights into distinct signaling profiles of the μOR activated by diverse agonists (2021) (13)
Pharmacological sequestration of a chimeric beta 3/beta 2 adrenergic receptor occurs without a corresponding amount of receptor internalization. (1996) (13)
Neuropeptide Y receptor 1 (NPY-Y1) expression in human heart failure and heart transplantation. (1998) (12)
Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation. (2016) (12)
Construction and expression of chimeric receptors to understand the structure-function relationships in adrenergic receptors (1991) (12)
Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. (1988) (12)
Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter‐Alkyl‐Chain Distance and Alkyl Chain Length (2016) (12)
Structural determinants of dual incretin receptor agonism by tirzepatide (2022) (11)
Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization, Stabilization and Crystallization (2013) (11)
An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability. (2018) (11)
Primary structure of the mouse β1-adrenergic receptor gene (1993) (10)
Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein. (1998) (10)
Efficient adenylyl cyclase activation by a β2-adrenoceptor-Giα2 fusion protein (2002) (10)
Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02981g Click here for additional data file. (2016) (10)
Tandem malonate-based glucosides (TMGs) for membrane protein structural studies (2017) (10)
Examination of ligand-induced conformational changes in the beta 2-adrenergic receptor by fluorescence spectroscopy. (1998) (10)
Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. (1998) (10)
Site-Specific Fluorescence Labeling of the β2Adrenergic Receptor Amino Terminus (1997) (10)
Structural Properties of the Human Protease-Activated Receptor 1 Changing by a Strong Antagonist. (2018) (9)
Fluorescent Labeling of Purified β2 Adrenergic Receptor (1995) (9)
Examination of ligand-induced conformational changes in the beta2 adrenergic receptor. (1998) (9)
Structure‐Based Evolution of G Protein‐Biased μ‐Opioid Receptor Agonists (2022) (9)
1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization. (2019) (9)
Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor β2-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus. (2021) (9)
Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms (2020) (9)
Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor. (1999) (9)
Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. (1988) (8)
Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability. (2019) (8)
Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics (2022) (8)
New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. (2017) (8)
Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization. (2020) (8)
Membrane phosphoinositides stabilize GPCR-arrestin complexes and provide temporal control of complex assembly and dynamics (2021) (8)
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins (2022) (7)
Ligand Stabilization of the â 2 Adrenergic Receptor : Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy † (7)
Conformational Plasticity of Human Protease-Activated Receptor 1 upon Antagonist- and Agonist-Binding. (2019) (7)
Structure and Conformational Changes in the C-terminal Domain of the β2-Adrenoceptor (2007) (7)
PDZ-domain arrays for identifying components of GPCR signaling complexes. (2006) (7)
Author Correction: Structural insights into μ-opioid receptor activation (2020) (7)
Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study. (2019) (7)
Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein (2017) (7)
CHAPTER 13 – Structure and Function of Adrenergic Receptors: Models for Understanding G Protein-Coupled Receptors (1990) (7)
New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability. (2020) (7)
G protein-coupled receptor activation (2005) (7)
Conformationally flexible core-bearing detergents with a hydrophobic or hydrophilic pendant: Effect of pendant polarity on detergent conformation and membrane protein stability. (2021) (7)
Genetic Alteration of (cid:97) 2C -Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective (cid:97) 2 Adrenoceptor Agonist (1997) (7)
Conformationally restricted monosaccharide-cored glycoside amphiphiles: the effect of detergent head group variation on membrane protein stability. (2019) (6)
Molecular and cellular biology of adrenergic receptors. (1991) (6)
Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy (2018) (6)
Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor. (1992) (6)
A device for separated and reversible co‐culture of cardiomyocytes (2010) (5)
Vitamin E-based glycoside amphiphiles for membrane protein structural studies. (2018) (5)
Translating science to medicine: The case for physician-scientists (2022) (5)
Dual Modulation of Cell Survival and Cell Death by β2-Adrenergic Gi and Gs Signaling in Adult Mouse Cardiac Myocytes (2000) (5)
Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: Impact of detergent hydrophobic group geometry on protein stability. (2019) (5)
Regulation of b 2 -Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies s (2014) (5)
Crystal structure of active mu-opioid receptor bound to the agonist BU72 (2015) (4)
Structure of the neurotensin receptor 1 in complex with β-arrestin 1 (2020) (4)
Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein. (1999) (4)
Anti-Brownian ELectrokinetic (ABEL) trapping of single β2-adrenergic receptors in the absence and presence of agonist (2012) (4)
Applications of molecular replacement to G protein-coupled receptors (2013) (4)
Steroid‐Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability (2018) (4)
Foldable detergents for membrane protein study: Importance of detergent core flexibility in protein stabilization. (2022) (4)
Local membrane charge regulates β2 adrenergic receptor coupling to Gi3 (2018) (3)
Antithetic regulation by b-adrenergic receptors of G q receptor signaling via phospholipase C underlies the airway b-agonist paradox (2018) (3)
Site-specific fluorescence labeling of the beta2 adrenergic receptor amino terminus. (1997) (3)
Author Correction: Structural insights into the activation of metabotropic glutamate receptors (2019) (3)
Structural insights into ligand efficacy and activation of the glucagon receptor (2019) (3)
Role of β-Adrenergic Signaling in Exercise Conditioning in Mice (1999) (3)
Faculty Opinions recommendation of Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4. (2010) (3)
Cannabinoid Receptor 1-G Protein Complex (2019) (3)
Glyco‐Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study (2022) (3)
Structure-based design of bitopic ligands for the µ-opioid receptor (2022) (3)
Calcineurin-fusion facilitates Cryo-EM Structure Determination of a Family A GPCR (2022) (3)
traol-based amphiphilic stereoisomers for membrane protein study : importance of chirality in the linker region † (2016) (2)
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation (2022) (2)
A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability. (2018) (2)
Cloning of the CDNA for the human f 31-adrenergic receptor ( catecholamines / transmembrane signaling / receptor subtypes ) (2)
Stable networks of water-mediated interactions are conserved in activation of diverse GPCRs (2018) (2)
The Biochemistry of G Protein-Coupled Receptors (2014) (2)
Crystal structure of the human beta2 adrenoceptor (2007) (2)
Restricting the Mobility of Gs R : Impact on Receptor and Effector Coupling (1999) (2)
Structure and dynamics of GPCR signaling complexes (2018) (2)
Diastereomeric Cyclopentane-Based Maltosides (CPMs) as Tools for Membrane Protein Study. (2020) (2)
Receptor-G Protein-Effector Coupling: Coding and Regulation of the Signal Transduction Process (1995) (2)
Primary structure of the mouse beta 1-adrenergic receptor gene. (1993) (2)
My early days in GPCR structural biology: From clone to crystal (2011) (2)
[15] Receptor chimers (1995) (2)
Structural insights into the dynamic process of G‐protein– coupled receptor activation (2012) (2)
Membrane Curvature Regulates the Oligomerization of Human β2-Adrenergic Receptors (2013) (2)
Structure of the human M1 muscarinic acetylcholine receptor bound to antagonist Tiotropium (2016) (2)
Phosphodiesterase 4D disruption causes β2 adrenergic receptors to behave like β1 adrenergic receptors in vivo (2006) (1)
The β-Adrenergic Receptors (2006) (1)
In meso in situ serial X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K (2016) (1)
Mu Opioid Receptor-Gi Protein Complex (2018) (1)
Dissecting the allosteric networks governing agonist efficacy and potency in G protein-coupled receptors (2021) (1)
Efficient adenylyl cyclase activation by a beta2-adrenoceptor-G(i)alpha2 fusion protein. (2002) (1)
Crystal structure of active Beta‐arrestin1 bound to phosphorylated carboxy‐terminus of a G protein‐coupled receptor (2013) (1)
Restricting mobility of G s a relative to the b 2 -adrenoceptor enhances adenylate cyclase activity by reducing G s a GTPase activity (1998) (1)
A Microsecond Time Scale Molecular Dynamics Simulation of B2AR in a Membrane (2009) (1)
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist (2018) (1)
Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor (2023) (1)
Muscarinic acetylcholine receptor 2-Go complex (2019) (1)
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620 (2013) (1)
Erratum: A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane protein (Chemistry - A European Journal (2012) 31) (2013) (1)
Time-resolved Conformational Analysis during GPCR-Gs Coupling (2020) (1)
Erratum: Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study (Chemical Communications (2013) 49 (2287-2289) DOI: 10.1039/c2cc36844g) (2013) (1)
Negative Allosteric Modulation of Arrestin Recruitment to the β2‐Adrenergic Receptor (2019) (1)
Conformational Changes in GPCR Surface and Core Probed by [13C]-Methyl NMR Spectroscopy (2010) (1)
Maltose-bis(hydroxymethyl)phenol (MBPs) and Maltose-tris(hydroxymethyl)phenol (MTPs) Amphiphiles for Membrane Protein Stability. (2021) (1)
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60 (2016) (1)
Response:Analysis of ligand binding specificity of receptor chimeras (1989) (1)
DISRUPTION OF THE β2 ADRENERGIC RECEPTOR PDZ BINDING MOTIF: IMPACT UPON CARDIAC STRUCTURE AND FUNCTION.: 58 (2005) (0)
Brian Kobilka: chipping away at the β2-adrenergic receptor. Interview by Ruth Williams. (2013) (0)
Metabotropic Glutamate Receptor 5 Extracellular Domain with Nb43 (2019) (0)
Response : Analysis of Ligand Binding Specificity of Receptor Chimeras (1989) (0)
Structure of human beta1 adrenergic receptor bound to norepinephrine and nanobody 6B9 (2020) (0)
Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium (2016) (0)
Cloning and expression of a human kidney cDNA for an a 2-adrenergic receptor subtype ( G protein / photoaffinity labeling / [ 3 Hjrauwolscine binding / a 2-adrenoceptor / a 2 B-adrenergc receptor ) (0)
Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex (2010) (0)
Negative allosteric modulation of the glucagon receptor by RAMP2 (2022) (0)
Tandem malonate-based glucosides (TMGs) for membrane protein structural studies (2017) (0)
Structure of human beta1 adrenergic receptor bound to epinephrine and nanobody 6B9 (2020) (0)
Metabotropic Glutamate Receptor 5 Apo Form (2019) (0)
Cell-type Specific Targeting of the a 2 c-Adrenoceptor EVIDENCE FOR THE ORGANIZATION OF RECEPTOR MICRODOMAINS DURING NEURONAL DIFFERENTIATION OF PC 12 CELLS (2000) (0)
M3-mT4L receptor bound to NMS (2014) (0)
Quantifying and localizing interactions guiding the structural and functional properties of GPCRs (2013) (0)
neurotensin receptor and arrestin2 complex (2020) (0)
Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy (2023) (0)
Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5. (1993) (0)
Directed evolution of nanobody chaperones that stabilize GPCR:G‐protein complexes (2017) (0)
Crystal structure of the designed light-gated anion channel iC++ at pH8.5 (2018) (0)
Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody (2014) (0)
Linkage mapping of α-2 adrenergic receptor genes to mouse Chromosomes 2 and 5 (1993) (0)
Efficacy at the Mu Opioid Receptor: Insights from Orthosteric and Allosteric Ligands (2016) (0)
Correction: Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability. (2019) (0)
An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptor (2021) (0)
Author Correction: Structural insights into the activation of metabotropic glutamate receptors (2019) (0)
human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) (2019) (0)
Modulation of cannabinoid receptor signaling by endocannabinoids (2022) (0)
Metabotropic Glutamate Receptor 5 bound to L-quisqualate and Nb43 (2019) (0)
Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L) (2014) (0)
The γ2 adrenergic receptor as a model for g-protein-coupled receptor structure and activation by diffusible hormones (2010) (0)
Structure of human beta1 adrenergic receptor bound to carazolol (2020) (0)
Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist (2017) (0)
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor (2023) (0)
Highly Accurate Quantification of the Oligomerization of the β2 Adrenergic Receptor using FRET (2012) (0)
Correction to “Tandem Facial Amphiphiles for Membrane Protein Stabilization” (2013) (0)
Advisory Board and Contents (2020) (0)
Abstract 341: Both Beta-1 and Beta-2 Adrenergic Receptors (ARs) are Required for Pressure Overload Cardiac Hypertrophy (2007) (0)
Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator (2020) (0)
Structural mechanisms of selectivity and gating in anion channelrhodopsins (2018) (0)
Structural Basis for Allosteric Enhancement of Agonist Affinity by G Proteins (2015) (0)
Signaling from β1‐ and β2‐adrenergic receptors is defined by differential interactions with PDE4 (2008) (0)
Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody (2013) (0)
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS (Hg-derivative) (2018) (0)
Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody (2013) (0)
Novel Insights into M3 Muscarinic Acetylcholine Receptor Physiology and Structure (2013) (0)
Crystal structure of the natural anion-conducting channelrhodopsin GtACR1 (2018) (0)
Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody (2013) (0)
Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles (2010) (0)
ltoside amphiphiles ( DTMs ) for membrane protein study † (2017) (0)
cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 (2020) (0)
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo (2013) (0)
Crystal structure of the designed light-gated anion channel iC++ at pH6.5 (2018) (0)
M3 muscarinic acetylcholine receptor in complex with a selective antagonist (2018) (0)
Arrestin C-tail dynamics regulate activation and GPCR engagement. (2023) (0)
Structure of beta2 adrenergic receptor fused to a Gs peptide (2019) (0)
Structure and Dynamics of the Human beta 2 Adrenoceptor (2008) (0)
Structural mechanisms of selectivity and high-speed gating in anion channelrhodopsins. (2018) (0)
Crystal structure of the natural light-gated anion channel GtACR1 (2018) (0)
In meso X-ray crystallography structure of the Beta2-adrenergic receptor at 100 K (2016) (0)
ž / Neuropeptide Y receptor 1 NPY-Y 1 expression in human heart failure and heart transplantation (0)
Negative allosteric modulation of the glucagon receptor by RAMP2. (2023) (0)
efficiently activates its G protein A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle (2007) (0)
Differential targeting of chimeric alpha2a and alpha2c adrenergic receptors in cultured mouse sympathetic neuronsalpha (2003) (0)
A701 WHERE DOES DEXMEDETOMIDINE BIND ON THE alpha sub 2A ADRENOCEPTOR (1997) (0)
Development of an antibody fragment that stabilizes GPCR/G-protein complexes (2018) (0)
Alpha2c-Adrenoceptor Overexpressing Mice as a Model to Study Cognitive Functions of Alpha2-Adrenoceptors (1997) (0)
Structural Basis for Allosteric Coupling Between G Protein and the Agonist‐Binding Pocket in GPCRs (2016) (0)
Inside Cover: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins (Chem. Eur. J. 31/2012) (2012) (0)
Structure determination of membrane (and soluble) proteins using in meso in situ serial X-ray crystallography at room and cryogenic temperatures (2016) (0)
News in brief (1980) (0)
Heterotrimeric G-protein in complex with an antibody fragment (2018) (0)
Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics (2023) (0)
Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9 (2020) (0)
SHORT ACTING BETA1 ADRENERGIC RECEPTOR BLOCKING AGENT ADMINISTERED ONCE DAILY IMPROVES CARDIAC FUNCTION IN MICE WITH FAILING HEARTS: 5 (2002) (0)
A single point mutation in the seventh hydrophobic domain of the alpha 2-adrenergic receptor changes antagonist binding specificity to that of a beta receptor. (1991) (0)
Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist (2017) (0)
human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) (2019) (0)
BRIEF REDUCTION IN ADRENERGIC RECEPTOR ACTIVATION DURING REST LOWERS MORTALITY IN A MURINE MODEL OF HEART FAILURE: 26 (2004) (0)
Muscarinic acetylcholine receptor 1-G11 protein complex (2019) (0)
Erratum: Author Correction: Structural insights into the activation of metabotropic glutamate receptors (Nature (2019) 566 7742 (79-84)) (2019) (0)
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384 (2018) (0)
Allosterism and Collateral Efficacy Conformational complexity of G-protein-coupled receptors (2007) (0)
Evolutionarily conserved trafficking signal within the alpha2c adrenergic receptor restricts plasma membrane expression (2008) (0)
How lipids influence the activity of β2-adrenergic receptor (2013) (0)
Cardiovascular β-Adrenergic Receptor Subtype Physiology Studied by Targeted Gene Disruption • 95 (1997) (0)
Crystal Structures of the 2 -Adrenergic Receptor (2009) (0)
An engineered lithocholate-based facial amphiphile stabilizes membrane proteins: assessing the impact of detergent modularity on protein stability (2020) (0)
An improved yeast surface display platform for the screening of nanobody immune libraries (2019) (0)
GCGR-Gs signaling complex bound to a designed glucagon derivative (2020) (0)
Structure of the GDP-bound Gs heterotrimer (2019) (0)
Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom (2012) (0)
M3-mT4L receptor bound to tiotropium (2014) (0)
Method and composition for the crystallization of G protein coupled receptors (2008) (0)
Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator (2019) (0)
Crystal structure of M2 muscarinic acetylcholine receptor bound with NMS (2018) (0)
ose neopentyl glycol amphiphiles for a membrane protein study : e ff ect of detergent asymmetricity on protein stability † (2019) (0)
Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex (2020) (0)
Crystal structure of human beta2 adrenergic receptor bound to salmeterol and Nb71 (2018) (0)
Metabotropic Glutamate Receptor 5 Apo Form Ligand Binding Domain (2019) (0)
Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex (2017) (0)
Symposium: Dynamics of G-Protein Coupled Receptors (2012) (0)
Distinct PDE4D splice variants regulate beta‐adrenergic signaling in neonatal mouse cardiac myocytes (2007) (0)
sympathetic nervous system hyperactivity in mice Abnormal cardiac function associated with (2006) (0)
A signal honour (2012) (0)
Structure and Dynamics of the Human beta 2 Adrenergic Receptor (2009) (0)
A cholesterol analog stabilizes the human β2-adrenergic receptor nonlinearly with temperature (2022) (0)
cryo-EM structure of alpha2BAR-Gi1 complex (2020) (0)
Mutational and Chimeric Studies on Adrenergic Receptors Reveal the Conformational Requirements for Agonist and Antagonist Binding (1993) (0)
The birth of the journal: the first anniversary of WIREs MTS (2013) (0)
CRYSTAL STRUCTURES OF THE E 2 -ADRENERGIC RECEPTOR (2009) (0)
The beta2 adrenergic receptor bound to a negative allosteric modulator (2020) (0)
Anti-Brownian ELectrokinetic (ABEL) Trapping of Single High Density Lipoprotein (HDL) Particles (2009) (0)
Disregulation of Akt associated with enhanced cardiotoxicity in β2-adrenergic receptor (AR) knockout mice: possible mechanism of crosstalk between β-receptors and HER2 in anthracycline cardiotoxicity (2003) (0)
ALIGNMENT OF THE TRANSMEMBRANE DOMAINS OF THE HUMAN [Greek small letter alpha]2A ADRENOCEPTOR (Hu [Greek small letter alpha]2A A) (1998) (0)
Regulation of Beta2-adrenergic Receptor Structure and Function (2011) (0)
Time-resolved cryo-EM of G protein activation by a GPCR (2023) (0)
Isoﬂurane and Nociception Spinal (cid:1) 2A Adrenoceptors Mediate Antinociception while Supraspinal (cid:1) 1 Adrenoceptors Mediate Pronociception (2002) (0)

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