Brian M. Frier

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Brian M. Frier is affiliated with the following schools: University of Edinburgh

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According to Wikipedia, Brian M. Frier is a Scottish physician, diabetologist, clinical scientist, and an Honorary Professor of Diabetes at the University of Edinburgh. He is best known for his many scientific contributions to the pathophysiological understanding of hypoglycemia, a common adverse effect of insulin therapy in diabetic patients whose societal impact has deserved increasing media attention worldwide. His honors include the R.D. Lawrence Lecture of the British Diabetic Association in 1986, the Banting Memorial Lecture at Diabetes UK in 2009, the Camillo Golgi Prize and lecture at the 53rd annual EASD conference in 2017, and the Michael Somogyi Award from the Hungarian Diabetes Association in 2004. Frier is a science book author and editor, and a science journal Chief editor. He is also regarded as an authority on the field of driving and diabetes. In 2023, Frier was accorded Honorary Life Membership by the European Association of Diabetes.

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Brian M. Frier's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Diabetes and cognitive dysfunction (2012) (718)
Frequency of Severe Hypoglycemia in Patients With Type I Diabetes With Impaired Awareness of Hypoglycemia (1994) (650)
Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use. (2003) (565)
Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies (1997) (536)
Frequency and predictors of hypoglycaemia in Type 1 and insulin‐treated Type 2 diabetes: a population‐based study (2005) (472)
Frequency of Thyroid Dysfunction in Diabetic Patients: Value of Annual Screening (1995) (454)
Hypoglycemia in type 2 diabetes: pathophysiology, frequency, and effects of different treatment modalities. (2005) (445)
Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study (2011) (361)
Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications (2014) (353)
The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations. (2004) (320)
Vascular disease and diabetes: is hypoglycaemia an aggravating factor? (2008) (316)
Prevalence of impaired awareness of hypoglycaemia in adults with Type 1 diabetes (2008) (312)
Hypoglycemia and Cardiovascular Risks (2011) (310)
Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia. (2003) (273)
Frequency and Morbidity of Severe Hypoglycaemia in Insulin‐treated Diabetic Patients (1993) (265)
Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. (2004) (264)
Hypoglycaemia in insulin‐treated Type 2 diabetes: frequency, symptoms and impaired awareness (2003) (264)
Symptoms of hypoglycaemia in people with diabetes (2001) (235)
Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function. (2005) (222)
Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis (1993) (214)
Severe Hypoglycemia and Cognitive Decline in Older People With Type 2 Diabetes: The Edinburgh Type 2 Diabetes Study (2014) (208)
Unawareness of Hypoglycaemia in Insulin‐treated Diabetic Patients: Prevalence and Relationship to Autonomic Neuropathy (1990) (200)
Glucose concentrations of less than 3.0 mmol/l (54 mg/dl) should be reported in clinical trials: a joint position statement of the American Diabetes Association and the Europian Association for the Study of Diabetes (2016) (200)
Hypoglycaemia and cognitive function (2005) (195)
How hypoglycaemia can affect the life of a person with diabetes (2008) (195)
Exocrine pancreatic function in juvenile-onset diabetes mellitus. (1976) (189)
Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management. (2019) (187)
Association Between Raised Inflammatory Markers and Cognitive Decline in Elderly People With Type 2 Diabetes (2009) (166)
Symptoms of Acute Insulin-Induced Hypoglycemia in Humans With and Without IDDM: Factor-Analysis Approach (1991) (165)
Minimizing Hypoglycemia in Diabetes (2015) (154)
Effects of Acute Insulin-Induced Hypoglycemia on Indices of Inflammation (2010) (152)
The impact of hypoglycaemia on quality of life and related patient‐reported outcomes in Type 2 diabetes: a narrative review (2012) (148)
Cumulative cognitive impairment following recurrent severe hypoglycaemia in adult patients with insulin-treated diabetes mellitus (1991) (147)
Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications (1998) (146)
Diabetes and driving mishaps: frequency and correlations from a multinational survey. (2003) (146)
Cognitive function and information processing in Type 2 diabetes (2001) (145)
Costs of managing severe hypoglycaemia in three European countries (2009) (144)
Frequency and Symptoms of Hypoglycaemia Experienced by Patients with Type 2 Diabetes Treated with Insulin (1993) (142)
Association Between Severe Hypoglycemia, Adverse Macrovascular Events, and Inflammation in the Edinburgh Type 2 Diabetes Study (2014) (141)
Brain Abnormalities Demonstrated by Magnetic Resonance Imaging in Adult IDDM Patients With and Without a History of Recurrent Severe Hypoglycemia (1997) (135)
The impact of diabetes on cognitive decline: potential vascular, metabolic, and psychosocial risk factors (2015) (129)
Severe Hypoglycemia and Intelligence in Adult Patients With Insulin-Treated Diabetes (1993) (126)
Prevalence of impaired awareness of hypoglycaemia and frequency of hypoglycaemia in insulin-treated type 2 diabetes. (2010) (125)
Perceived symptoms of hypoglycaemia in elderly Type 2 diabetic patients treated with insulin (1998) (124)
The Edinburgh Type 2 Diabetes Study: study protocol (2008) (116)
Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome: Population-Based Study (2015) (114)
Impaired awareness of hypoglycaemia: a review. (2010) (113)
Increased CD40 ligand and platelet-monocyte aggregates in patients with type 1 diabetes mellitus. (2004) (111)
Recovery of cognitive function and mood after severe hypoglycemia in adults with insulin-treated diabetes. (2000) (111)
Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study. (2010) (108)
Hypoglycaemia and accident risk in people with type 2 diabetes mellitus treated with non-insulin antidiabetes drugs (2012) (107)
Short-term, delayed, and working memory are impaired during hypoglycemia in individuals with type 1 diabetes. (2003) (103)
The relationship between type 2 diabetes and dementia. (2008) (101)
An Evaluation of Methods of Assessing Impaired Awareness of Hypoglycemia in Type 1 Diabetes (2007) (98)
Seeing beyond retinopathy in diabetes: electrophysiological and psychophysical abnormalities and alterations in vision. (1998) (97)
Hypoglycaemia, the most feared complication of insulin therapy. (1994) (97)
Altered Taste Sensation in Newly-Diagnosed NIDDM (1996) (95)
Hypoglycemia and Cardiovascular Risk: Is There a Major Link? (2016) (91)
Child and parental mental ability and glycaemic control in children with Type 1 diabetes (2001) (89)
Hypoglycemia-induced cognitive dysfunction in diabetes mellitus: Effect of hypoglycemia unawareness (1995) (87)
Diabetic Retinopathy and Cognitive Decline in Older People With Type 2 Diabetes (2010) (85)
Visual information processing during controlled hypoglycaemia in humans. (1996) (84)
Type 2 diabetes and cognitive impairment (2003) (84)
Oral manifestations of previously undiagnosed non-insulin dependent diabetes mellitus. (1990) (81)
Morning Cortisol Levels and Cognitive Abilities in People With Type 2 Diabetes (2010) (79)
Frequency, severity, and morbidity of hypoglycemia occurring in the workplace in people with insulin-treated diabetes. (2005) (78)
Morbidity of hypoglycemia in type 1 diabetes. (2004) (78)
Changes in mood during acute hypoglycemia in healthy participants. (1995) (75)
Hypoglycaemia: an overview. (2009) (74)
Acute hypoglycemia in humans causes attentional dysfunction while nonverbal intelligence is preserved. (2001) (73)
Hypoglycaemia in clinical diabetes (2007) (72)
Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study (2010) (70)
Hypoglycemia Unawareness Is Associated With Reduced Adherence to Therapeutic Decisions in Patients With Type 1 Diabetes: Evidence from a Clinical Audit (2010) (69)
Vessel wall stiffness in type 1 diabetes and the central hemodynamic effects of acute hypoglycemia. (2007) (69)
Type 1 Diabetes and Driving Experience: an Eight‐year Cohort Study (1989) (67)
Diabetes and driving (2013) (66)
Nocturnal hypoglycemia: clinical manifestations and therapeutic strategies toward prevention. (2003) (66)
Symptoms of Hypoglycemia in Children With IDDM (1995) (65)
Driving after stroke. (1986) (65)
DRIVING AND INSULIN-DEPENDENT DIABETES (1980) (63)
DOES HYPOGLYCAEMIA AGGRAVATE THE COMPLICATIONS OF DIABETES? (1985) (63)
Need for Regulatory Change to Incorporate Beyond A1C Glycemic Metrics (2018) (63)
Severe hypoglycaemia in adults with insulin‐treated diabetes: impact on healthcare resources (2015) (62)
Acute Hypoglycemia Impairs Executive Cognitive Function in Adults With and Without Type 1 Diabetes (2013) (61)
Which abilities does the PASAT test (1991) (61)
Moderate hypoglycemia impairs multiple memory functions in healthy adults. (2003) (60)
Delayed Recovery of Cognitive Function Following Hypoglycemia in Adults With Type 1 Diabetes (2008) (60)
Hypoglycaemia and Diabetes (1986) (59)
Effect of acute hypoglycemia on visual information processing in adults with type 1 diabetes mellitus (1998) (58)
The symptoms of hyperglycaemia in people with insulin‐treated diabetes: classification using principal components analysis (2003) (58)
Structural Equation Modeling of Symptoms, Awareness and Fear of Hypoglycemia, and Personality in Patients With Insulin-Treated Diabetes (1994) (55)
Peripheral blood cell changes in response to acute hypoglycaemia in man (1983) (52)
Severe hypoglycaemia and cognitive impairment in diabetes (1996) (52)
The effects of insulin-induced hypoglycaemia on cardiovascular function in normal man: studies using radionuclide ventriculography (1987) (52)
Cardiac responses to acute insulin-induced hypoglycemia in humans. (1990) (52)
Addison's disease in type 1 diabetes presenting with recurrent hypoglycaemia (2000) (51)
and Cardiovascular Risks (2011) (51)
Hypoglycaemia and diabetes : clinical and physiological aspects (1993) (51)
Diabetes, cognitive impairment, and dementia (2008) (51)
Drug-induced hypoglycaemia in type 2 diabetes (2012) (50)
Hypoglycaemia in adults with insulin‐treated diabetes in the UK: self‐reported frequency and effects (2015) (50)
Metabolic parameters associated with arterial stiffness in older adults with Type 2 diabetes: the Edinburgh Type 2 Diabetes Study (2013) (49)
Regional cerebral blood flow in IDDM patients: Effects of diabetes and of recurrent severe hypoglycaemia (1994) (49)
Circulating C-Peptide: Measurement and Clinical Application (1981) (48)
Severe hypoglycaemia in patients with type 1 diabetes and impaired awareness of hypoglycaemia: a comparative study of insulin lispro and regular human insulin (2001) (48)
Appraisal of Mood and Personality During Hypoglycaemia in Human Subjects (1999) (47)
Food cravings during acute hypoglycaemia in adults with Type 1 diabetes (2004) (46)
Recurrent severe hypoglycemia, intelligence, and speed of information processing (1992) (45)
Cholinergic manifestations of the acute autonomic reaction to hypoglycaemia in man. (1983) (44)
Recurrent Severe Hypoglycaemia and Cognitive Function in Type 1 Diabetes (1993) (44)
A comparison of insulin detemir and neutral protamine Hagedorn (isophane) insulin in the treatment of diabetes: a systematic review (2013) (44)
Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease (1986) (43)
Auditory information processing during acute insulin-induced hypoglycaemia in non-diabetic human subjects (1997) (42)
Effects of Acute Insulin-Induced Hypoglycemia on Spatial Abilities in Adults With Type 1 Diabetes (2009) (41)
The effects of acute hypoglycemia on relative cerebral blood flow distribution in patients with type I (insulin-dependent) diabetes and impaired hypoglycemia awareness. (1996) (41)
Hypoglycemic Convulsions Cause Serious Musculoskeletal Injuries in Patients With IDDM (1989) (41)
Acute hypoglycemia impairs the functioning of the central but not peripheral nervous system (2001) (41)
Association between connective tissue changes and smoking habit in type 2 diabetes and in non-diabetic humans. (1991) (41)
Thyroid Autoimmunity at Onset of Type 1 Diabetes as a Predictor of Thyroid Dysfunction (2007) (40)
Hypoglycaemia and Non‐cognitive Aspects of Psychological Function in Insulin‐dependent (Type 1) Diabetes Mellitus (IDDM) (1997) (40)
The risks of nocturnal hypoglycaemia in insulin-treated diabetes. (2017) (40)
Moderate hypoglycaemia obliterates working memory in humans with and without insulin treated diabetes (2003) (39)
Driving and diabetes: problems, licensing restrictions and recommendations for safe driving (2015) (39)
Hypoglycaemia symptoms and impaired awareness of hypoglycaemia in adults with Type 1 diabetes: the association with diabetes duration (2014) (38)
Hypoglycaemia and cognitive function in diabetes. (2001) (38)
Optimal Time of Administration of Insulin Lispro. Importance of meal composition (1998) (38)
Limited Joint Mobility, Dupuytren's Contracture and Retinopathy in Type 1 Diabetes: Association with Cigarette Smoking (1989) (37)
Increased Collagen-Linked Fluorescence in Skin of Young Patients With Type I Diabetes Mellitus (1990) (37)
The role of metabolic derangements and glucocorticoid excess in the aetiology of cognitive impairment in type 2 diabetes. Implications for future therapeutic strategies (2009) (36)
Cognitive function during hypoglycemia in type I diabetes mellitus. (1986) (36)
Medically minimising the impact of hypoglycaemia in type 2 diabetes: a review (2011) (35)
The effects of acute hypoglycaemia on cognitive function in type 1 diabetes (2012) (35)
Leucocyte Mobilization and Release of Neutrophil Elastase Following Acute Insulin‐induced Hypoglycaemia in Normal Humans (1990) (35)
The effects of acute hypoglycaemia on memory acquisition and recall and prospective memory in type 1 diabetes (2006) (34)
The use of ultrasound to diagnose hepatic steatosis in type 2 diabetes: intra- and interobserver variability and comparison with magnetic resonance spectroscopy. (2011) (34)
Modeling the consistency of hypoglycemic symptoms: high variability in diabetes. (2011) (34)
Serum thyrotropin is a better predictor of future thyroid dysfunction than thyroid autoantibody status in biochemically euthyroid patients with diabetes: implications for screening. (2004) (32)
Prevalence and markers of advanced liver disease in type 2 diabetes. (2012) (32)
Frequency of symptomatic and asymptomatic hypoglycaemia in Type 1 diabetes: effect of impaired awareness of hypoglycaemia (2010) (32)
Effects of Acute Hypoglycemia on Working Memory and Language Processing in Adults With and Without Type 1 Diabetes (2015) (32)
Cardiac function and insulin-dependent diabetes: radionuclide ventriculography in young diabetics. (1985) (31)
Evaluation of serum markers of neuronal damage following severe hypoglycaemia in adults with insulin‐treated diabetes mellitus (1999) (30)
Impaired Awareness of Hypoglycaemia (2007) (30)
A structural equation model for predictors of severe hypoglycaemia in patients with insulin-dependent diabetes mellitus. (1997) (30)
Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Is Not Associated With Autonomic Dysfunction or Peripheral Neuropathy (2015) (29)
Hypoglycemia and driving performance. (2000) (29)
Plasma squalene: lipoprotein distribution and kinetic analysis. (1978) (28)
Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus (2016) (28)
Anger State During Acute Insulin-Induced Hypoglycaemia (1999) (28)
Effects of acute insulin-induced hypoglycaemia on psychomotor function: people with type 1 diabetes are less affected than non-diabetic adults (2008) (28)
Optimal Glycaemic Control in Elderly People with Type 2 Diabetes: What Does the Evidence Say? (2014) (28)
Insulin analogues and other developments in insulin therapy for diabetes (2003) (28)
Plasma insulin, C-peptide and glucagon concentrations in patients with insulin-independent diabetes treated with chlorpropamide. (1981) (28)
Physiological manipulation of psychometric mood factors using acute insulin-induced hypoglycaemia in humans (1995) (27)
Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus (2017) (27)
Arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia in type 1 (insulin-dependent) diabetes. (1989) (27)
Cognitive assessment in diabetes: the need for consensus (1997) (27)
Constructs and models in health psychology: The case of personality and illness reporting in diabetes mellitus (1997) (27)
Detection of microalbuminuria in diabetic patients using a simple latex agglutination test. (1987) (27)
Symptomatic and counterregulatory hormonal responses to acute hypoglycaemia induced by insulin aspart and soluble human insulin in Type 1 diabetes (2000) (26)
Responses to acute insulin-induced hypoglycaemia in diabetic patients: a comparison of short-acting human and porcine insulins. (1988) (26)
Hypoglycemia and Cognitive Function (1993) (26)
Hypoglycemia in type 2 diabetes (2008) (26)
Renal resistance to vasopressin in poorly controlled type 1 diabetes mellitus. (2000) (26)
Apolipoprotein-e influences aspects of intellectual ability in type 1 diabetes. (2003) (26)
Hypoglycaemic symptoms reported by children with Type 1 diabetes mellitus and by their parents (1998) (25)
Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur (1995) (25)
Vascular Endothelial Cell Antibodies in Diabetic Patients: Association With Diabetic Retinopathy (1992) (25)
Prevalence of impaired awareness of hypoglycemia and identification of predictive symptoms in children and adolescents with type 1 diabetes (2014) (25)
HYPOGLYCAEMIC UNAWARENESS AND HUMAN INSULIN (1989) (24)
Acute hypoglycemia impairs nonverbal intelligence: importance of avoiding ceiling effects in cognitive function testing. (2004) (24)
Impact of severe hypoglycaemia on psychological outcomes in adults with Type 2 diabetes: a systematic review (2019) (24)
Acute hypoglycemia in man: neural control of pancreatic islet cell function. (1981) (24)
Cognitive deficits associated with impaired awareness of hypoglycaemia in type 1 diabetes (2017) (24)
Treatment and prevention of severe hypoglycaemia in people with diabetes: Current and new formulations of glucagon (2019) (23)
Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes (2015) (22)
Modeling the effects of hypoglycemia on a two-choice task in adult humans. (2010) (22)
Adrenaline and psychometric mood factors: A controlled case study of two patients with bilateral adrenalectomy (1996) (22)
Coagulation and fibrinolytic systems in type I diabetes: effects of venous occlusion and insulin-induced hypoglycaemia. (1993) (22)
Psychological and Demographic Correlates of Glycaemic Control in Adult Patients with Type 1 Diabetes (1994) (22)
The economic costs of hypoglycaemia (2011) (22)
Hypoglycaemia in the diabetic adult. (1993) (21)
Counterregulatory hormonal responses to hypoglycaemia in Type 1 (insulin-dependent) diabetes: evidence for diminished hypothalamic-pituitary hormonal secretion (1988) (21)
The long-term sequelae of severe hypoglycemia on the brain in insulin-dependent diabetes mellitus. (1997) (21)
Symptomatic Awareness of Hypoglycaemia: Does it Change on Transfer from Animal to Human Insulin? (1989) (21)
Association Between Excessive Daytime Sleepiness and Severe Hypoglycemia in People With Type 2 Diabetes (2013) (21)
Chronic Pontine Dysfunction Following Insulin-Induced Hypoglycemia in an IDDM Patient (1994) (21)
Does hypoglycaemia cause cardiovascular events (2010) (21)
Pubertal stage and hypoglycaemia counterregulation in type 1 diabetes (2005) (20)
Abnormal Insulin Secretion in Carcinoma of the Pancreas: Response to Glucagon Stimulation (1985) (20)
Usefulness of cardiovascular tests of autonomic function in asymptomatic diabetic patients. (1989) (20)
Young adults with Type 1 diabetes in tertiary education: do students receive adequate specialist care? (2006) (20)
Physiological, Symptomatic and Hormonal Responses to Acute Hypoglycaemia in Type 1 Diabetic Patients with Autonomic Neuropathy (1993) (19)
Frequency, Severity and Symptomatology of Hypoglycaemia: a Comparative Trial of Human and Porcine Insulins in Type 1 Diabetic Patients (1995) (19)
Intensified conventional insulin treatment and neuropsychological impairment. (1992) (19)
Cognitive function during insulin-induced hypoglycemia in humans: short-term cerebral adaptation does not occur (1995) (18)
Serum trypsin concentration and pancreatic trypsin secretion in insulin-dependent diabetes mellitus. (1980) (17)
Managing hypoglycaemia. (2005) (17)
Cognitive Ability and Brain Structure in Type 1 Diabetes Relation to Microangiopathy and Preceding Severe (2003) (16)
PLASMA NORADRENALINE, HUMAN INSULIN, AND HYPOGLYCAEMIA (1989) (16)
Nocturnal convulsions and insulin-induced hypoglycaemia in diabetic patients. (1987) (16)
Histological findings in clinically normal skin of patients with insulin‐dependent diabetes (1987) (16)
The effect of IQ level on the degree of cognitive deterioration experienced during acute hypoglycemia in normal humans (1995) (16)
Hypoglycaemic valleys: an under-recognised problem in type 2 diabetes? (2002) (16)
Incidence and severity of hypoglycaemia in type 2 diabetes by treatment regimen: A UK multisite 12‐month prospective observational study (2019) (16)
Non‐invasive risk scores do not reliably identify future cirrhosis or hepatocellular carcinoma in Type 2 diabetes: The Edinburgh type 2 diabetes study (2020) (16)
Review: Does hypoglycaemia cause cardiovascular events? (2010) (15)
Living with Hypoglycaemia (2013) (15)
Basal‐bolus insulin therapy in Type 1 diabetes: comparative study of pre‐meal administration of a fixed mixture of insulin lispro (50%) and neutral protamine lispro (50%) with human soluble insulin (2002) (15)
The Effects of Acute Insulin‐induced Hypoglycaemia on Renal Function in Normal Human Subjects (1989) (15)
Factors influencing preference of insulin regimen in people with type 1 (insulin-dependent) diabetes. (1998) (15)
An Audit of Waiting Times in the Diabetic Outpatient Clinic: Role of Patients' Punctuality and Level of Medical Staffing (1996) (14)
Impaired hypoglycaemia awareness and employment in people with Type 1 diabetes. (2011) (14)
More on the evidence for a specific heart disease of Type 1 (insulin-dependent) diabetes (1987) (14)
Commencing insulin glargine 100 U/mL therapy in individuals with type 2 diabetes: Determinants of achievement of HbA1c goal less than 7.0% (2019) (13)
Plasma Hepatic Glutathione S‐Transferase Concentrations after Insulin‐Induced Hypoglycaemia in Normal Subjects and Diabetic Patients (1989) (13)
A UK Civil Aviation Authority protocol to allow pilots with insulin-treated diabetes to fly commercial aircraft. (2017) (13)
Effects of Adrenergic Blockade on Serum Potassium Changes in Response to Acute Insulin-Induced Hypoglycemia in Nondiabetic Humans (1991) (13)
Glucagon Administration by Nasal and Intramuscular Routes in Adults With Type 1 Diabetes During Insulin-Induced Hypoglycaemia: A Randomised, Open-Label, Crossover Study (2020) (13)
Diabetes, driving, and the general practitioner. (1985) (13)
Effects of Sleep Deprivation on Hypoglycemia-Induced Cognitive Impairment and Recovery in Adults With Type 1 Diabetes (2016) (13)
Fasting C‐peptide, a biomarker for hypoglycaemia risk in insulin‐naïve people with type 2 diabetes initiating basal insulin glargine 100 U/mL (2019) (12)
Serum trypsin concentrations in diabetes mellitus. (1978) (12)
Splenic responses to acute insulin-induced hypoglycaemia in humans. (1990) (11)
Relationship between HbA1c and hypoglycaemia in patients with type 2 diabetes treated with different insulin regimens in combination with metformin (2009) (11)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Cholesterol metabolism in diabetes: the effect of insulin on the kinetics of plasma squalene. (1979) (11)
Diabetes Mellitus and Criminal Responsibility (1984) (11)
Urinary excretion of beta-thromboglobulin and N-acetyl-beta-D-glucosaminidase in type 1 diabetes: potential indicators of early nephropathy? (1990) (11)
Do diabetes guidelines influence the content of referral letters by general practitioners to a diabetes specialist clinic? (2000) (10)
Lower rates of hypoglycaemia in older individuals with type 2 diabetes using insulin degludec versus insulin glargine U100: Results from SWITCH 2 (2019) (10)
Driving and diabetes. (1992) (10)
Temporal changes in frequency of severe hypoglycemia treated by emergency medical services in types 1 and 2 diabetes: a population-based data-linkage cohort study (2017) (10)
Diabetes and Driving (2013) (9)
Suppression of plasma intact parathyroid hormone levels during insulin-induced hypoglycemia in humans. (1992) (9)
Cholestatic jaundice following chlorpropamide self-poisoning. (1977) (9)
Basal ganglia calcification in BB/E rats with diabetes (2005) (9)
Fatal cardiac arrest following acute hypoglycaemia in a diabetic patient (1995) (9)
Hypoglycaemia--clinical consequences and morbidity. (2000) (9)
Driving and diabetes: DVLA response to Lonnen et al. (2009) (8)
An Evaluation of the Safety of Pilots With Insulin-Treated Diabetes in Europe Flying Commercial and Noncommercial Aircraft (2020) (8)
Effects of Acute Hypoglycemia on Motivation and Cognitive Interference in People with Type 1 Diabetes (2006) (8)
A global survey of licensing restrictions for drivers with diabetes (2017) (8)
Tight glucose control and diabetic complications (1993) (8)
Dementia and hypoglycemic episodes in patients with type 2 diabetes mellitus. (2009) (8)
Hypoglycemia evaluation and reporting in diabetes: Importance for the development of new therapies (2017) (8)
Fall in intraocular pressure during acute hypoglycaemia in patients with insulin dependent diabetes: (1987) (8)
Comprar Living with Hearing Difficulties: The process of enablement | Brian M. Frier | 9780470019856 | Wiley (2009) (7)
Glycosylated haemoglobin. Part I: Measurement and clinical interpretation. (1985) (7)
Glycemic control and raised serum alanine aminotransferase activity in treated diabetes mellitus. (1988) (7)
Hypoglycaemia unawareness in adult patients with Type 1 diabetes: Relationship to severe hypoglycaemia and cognitive impairment. (1994) (7)
Hypoglycaemic coma associated with gastric carcinoma. (1986) (7)
Hypoglycaemia in Type 2 Diabetes and in Elderly People (2013) (7)
Abdominal pain and vomiting in a paint stripper. (1996) (7)
Hypoglycaemia is uncommon with a combination of antidiabetic drugs and bedtime NPH insulin for type 2 diabetes (2004) (7)
Autonomic neural control mechanisms and the release of adrenal steroids after hypoglycaemia in man. (2008) (7)
Diabetes and Driving (2011) (7)
Pharmacokinetics of Human Insulin Zinc Suspension (Recombinant DNA) in Normal Man: A Comparison with Porcine Insulin Zinc Suspension (1984) (7)
(18)F-fluorodeoxyglucose uptake in brown adipose tissue during insulin-induced hypoglycemia and mild cold exposure in non-diabetic adults. (2014) (7)
Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes (2010) (7)
Fall in intraocular pressure during acute hypoglycaemia in patients with insulin dependent diabetes. (1987) (6)
Hypoglycaemia Unawareness in Patients with Insulin-treated Diabetes Mellitus (1991) (6)
A misplaced medal? 50 years of unnecessary insulin treatment. (1983) (6)
Changes in plasma renin activity after hypoglycaemia in sympathectomized man. (1981) (6)
Severe hypoglycaemia in insulin‐treated Type 2 diabetes (2007) (6)
Moderate hypoglycaemia after learning does not affect memory consolidation and brain activation during recognition in non‐diabetic adults (2008) (6)
Hypoglycaemia In Clinical Diabetes 3rd Ed. (2014) (6)
Urinary dopamine response to angiotensin II is not abnormal in type 1 (insulin-dependent) diabetes mellitus. (1993) (6)
Post-partum hypoglycaemia in lactating women with type 1 diabetes: a pilot study using continuous glucose monitoring (2015) (6)
C‐peptide determination in the diagnosis of type of diabetes and its management: A clinical perspective (2022) (6)
Risk of Severe Hypoglycemia in Diabetic Patients Taking ACE Inhibitors (1998) (6)
Self-Reported Frequency and Impact of Non-Severe Hypoglycaemia in Insulin-Treated Adults in the UK. (2014) (5)
Human growth hormone and restoration of hypoglycaemia awareness (1992) (5)
Hippocampal volume and cognitive performance in long‐standing Type 1 diabetic patients without macrovascular complications (2006) (5)
Blood glucose testing by drivers with diabetes: a survey of glucose meter users (2015) (5)
Cerebral oedema in diabetic ketoacidosis. (1975) (5)
6. Impaired Awareness of Hypoglycaemia (2013) (5)
Early Postprandial Hypoglycemia Following Administration of Lispro Insulin (1997) (5)
Liver function tests after hypoglycaemia in insulin‐dependent‐diabetic patients (1988) (5)
Reporting of hypoglycaemia in clinical trials of basal insulins: A need for consensus (2019) (5)
Epidemiology, short and long-term consequences of hypoglycaemia. (2002) (5)
The role of cortisol in the peripheral granulocyte response to insulin-induced hypoglycaemia in man. (1989) (5)
Attenuation of the pancreatic beta cell response to a meal following hypoglycaemia in man (1980) (5)
Changes in the anterior chamber of the eye during acute hypoglycaemia in humans. (1993) (5)
Renewal of driving licences and long duration insulin‐treated diabetes: a comparison of medical assessment and self‐reporting by drivers (2012) (4)
Assessing awareness of hypoglycemia in children and adolescents with type 1 diabetes: Evaluation of established questionnaires (2019) (4)
Renal tubular responses to low-dose infusion of angiotensin II in type 1 diabetes mellitus; relation to chronic glycaemic control. (1994) (4)
Autonomic mechanisms underlying intraocular pressure changes during insulin-induced hypoglycaemia in normal human subjects: effects of pharmacological blockade. (1991) (4)
The Effect of Adrenergic and Cholinergic Mechanisms on the Release of ACTH and Adrenal Steroids following Hypoglycaemia in Man (1982) (3)
Coeliac disease often co‐exists with Type 1 diabetes mellitus (1998) (3)
Young‐onset type 2 diabetes: A neglected group requiring urgent attention (2022) (3)
Driving and diabetes: are the changes in the European Union licensing regulations fit for purpose? (2018) (3)
Addition of hyaluronic acid to the FIB‐4 liver fibrosis score improves prediction of incident cirrhosis and hepatocellular carcinoma in type 2 diabetes: The Edinburgh Type 2 Diabetes Study (2021) (3)
Type 2 diabetes and cognitive impairment: The Edinburgh Type 2 Diabetes Study (2008) (3)
1. Epidemiology and Impact of Hypoglycemia on Patients with Diabetes (2012) (3)
Insulin Therapy: A Pocket Guide (2013) (3)
Intensive Glycaemic Management in Type 1 Diabetes: A Commentary (2003) (3)
Evaluation of an on‐call diabetes service in a large teaching hospital (2000) (3)
Hypoglycemia during adrenergic beta-blockade: evidence against mediation via a deficiency of lactate for gluconeogenesis. (1985) (3)
Medical assessment for licensing of taxi drivers by Scottish local authorities. (1997) (3)
Accident Risk of the Diabetic Driver (1989) (3)
Management of insulin-dependent diabetes: Hypoglycaemia and the eye (1993) (3)
Effect of alpha-adrenergic blockade on pituitary hormonal responses to insulin-induced hypoglycemia in humans. (1991) (3)
Diabetes 2 Diabetes and cognitive dysfunction (2012) (3)
Symptomatic hypothalamic hypopituitarism following radiotherapy (1979) (3)
Lawrence Lecture. Hypoglycaemia and diabetes. (1986) (3)
Diabetes and Driving (2012) (3)
Hypoglycaemia risk in the first 8 weeks of titration with insulin glargine 100 U/mL in previously insulin‐naive individuals with type 2 diabetes mellitus (2018) (3)
Side-Effects of Insulin (2013) (3)
Insulin Degludec Has Lower Hypoglycemia Risk than Insulin Glargine U100 in Older People with Type 2 Diabetes (T2D) (2018) (3)
Syndrome(s) X (1991) (2)
Permanent brain damage following parasuicide with severe insulin-induced hypoglycaemia (2018) (2)
Drug treatment during Ramadan. Don't be complacent about diabetes. (1993) (2)
Limited Knowledge of Safe Driving Practice among Drivers with Diabetes in Armenia: Association with Greater Risk of Motor Vehicle Accidents (2019) (2)
100 years on: the impact of the discovery of insulin on clinical outcomes (2021) (2)
USA joins Canada, UK, Ireland and Austria in allowing people with insulin‐treated diabetes to fly commercial aircraft (2020) (2)
SGLT inhibitors and euglycaemic diabetic ketoacidosis: earlier observations rediscovered (2019) (2)
The impact of diabetes on cognitive decline (2015) (2)
Appreciating, predicting, and preventing hypoglycaemia (2004) (2)
Diabetes and Hypoglycaemia: Medicolegal Aspects of Criminal Responsibility (1988) (2)
Restoration of perception of hypoglycaemia after hemiparesis in an insulin dependent diabetic patient. (1990) (2)
The hypo awareness questionnaire : design of a novel measure of awareness of hypoglycaemia for use in the UK Hypo COMPaSS trial (2011) (2)
Impairs Executive Cognitive Function in Adults With and Without Type 1 Diabetes (2013) (2)
Cortisol and cognition in type 2 diabetes (2010) (1)
Hypoglycaemia and driving. Authors' reply (2005) (1)
Comprar Hypoglycaemia In Clinical Diabetes 3rd Ed. | Brian M. Frier | 9780470672006 | Wiley (2014) (1)
A new cause of neuroglycopenia: 'missing the point'-impaired visual function during acute hypoglycaemia. (2005) (1)
Determining the risk of hypoglycaemia in people with type 2 diabetes: an approach for clinical practice (2010) (1)
Scrotal gangrene in asymptomatic myeloma. (1972) (1)
Acute hypoglycaemia in man. (1981) (1)
Distribution and characteristics of newly-defined subgroups of type 2 diabetes in randomised clinical trials: post hoc cluster assignment analysis of over 12,000 study participants. (2022) (1)
Letter: Cerebral oedema in diabetic ketoacidosis. (1975) (1)
Diabetic control and left ventricular fraction. (1985) (1)
Association of accelerated retinopathy with restoration of normoglycaemia in Type 2 diabetes (1992) (1)
Nasal Glucagon: Potentially Viable Alternative to Treat Insulin-Induced Hypoglycemia in Adults with Type 1 Diabetes (2018) (1)
History, Normal Physiology, and Production of Insulin (2013) (1)
Hypoglycaemia in acute myelomonoblastic leukaemia. (1985) (1)
Cognitive dysfunction after concussion (1998) (1)
Regarding Insulin Initiation in Type 2 Diabetes Mellitus and the Risk for Hypoglycemia. (2017) (1)
Hypoglycaemia was validated (1995) (1)
Abnormalities of cardiac conduction in diabetics (1985) (1)
Welcome to Diabetic Hypoglycemia – an essential new source for hypoglycemia awareness (2008) (1)
Syndrome of inappropriate ADH secretion concealed by hypokalaemia due to ectopic ACTH production. (1981) (1)
DRIVING AFTER STROKE (1986) (1)
Identifying and treating hypoglycemia in insulin-treated diabetes (2021) (1)
Misleading plasma electrolytes in diabetic children (2006) (1)
Previously unrecognized risk factors for severe hypoglycaemia requiring emergency medical care in insulin‐treated type 2 diabetes: Results from a real‐world nested case‐control study (2022) (1)
Blood glucose monitoring by insulin‐treated pilots of commercial and private aircraft: An analysis of out‐of‐range values (2021) (1)
Personal View (1980) (0)
CONNECTIVE TISSUE ABNORMALITIES IN DIABETES (1984) (0)
PCD Orals (1999) (0)
Hypoglycaemia and the brain (2005) (0)
Hypoglycemia in elderly people with diabetes (2013) (0)
Prevalence and markers of advanced liver disease in people with type 2 diabetes: the Edinburgh type 2 diabetes study (2011) (0)
Edinburgh Explorer Severe hypoglycemia and cognitive decline in older people with type 2 diabetes (2017) (0)
Initiating and Adjusting Insulin (2013) (0)
Spontaneous biochemical nocturnal hypoglycemia in type 1 diabetes is associated with an increased risk of hypoglycemia the following day (2004) (0)
EXPERIMENTAL INDUCED HYPOGLYCEAMIA (1996) (0)
The mechanism of abnormal pancreatic beta cell response to food following acute hypoglycaemia in man. (1981) (0)
Natural deaths of road users. (1988) (0)
Hypoglycemia and cardiovascular outcomes (2012) (0)
Glycosylated Haemoglobin (1985) (0)
Case Conference (1999) (0)
Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: A prospective, randomised, open‐label, blinded endpoint, cross‐over study (2021) (0)
Optic disc oedema in first degree relatives with different macrovascular risk factors (type 1 diabetes and hypertension) (2001) (0)
Intensive lifestyle intervention has little effect on cardiovascular complications in people with type 2 diabetes. (2013) (0)
Magnetic resonance imaging and spectroscopy of the brain in a diabetic patient after severe hypoglycemia (2000) (0)
Optimal Carbohydrate Dose for Treatment of Nonsevere Hypoglycemia in Insulin-Treated Patients With Diabetes: A Narrative Review. (2022) (0)
Prevalence and Associations of Microalbuminuria in Patients with Newly Diagnosed Type 2 (non-Insulin Dependent) Diabetes Mellitus (1989) (0)
Subcutaneous Insulin Administration (2013) (0)
Hypoglycaemia risk in the first eight weeks of titration with insulin glargine 100 U/mL in previously insulin-naive people with type 2 diabetes mellitus: Hypoglycaemia during insulin initiation in type 2 diabetes mellitus (2018) (0)
[Does recurrent exposure to severe hypoglycaemia affect cognitive function?]. (2007) (0)
Response to insulin glargine 100 U/mL treatment in newly-defined subgroups of type 2 diabetes: Post hoc pooled analysis of insulin-naïve participants from nine randomised clinical trials. (2023) (0)
Recurrent hypoglycaemia caused by metastatic insulinoma in a patient with Type 2 diabetes (2007) (0)
Clinical value of serum immunoreactive trypsin concentration (1982) (0)
Lithium Invalidates Direct Comparison of the Pressor Response to Angiotensin II (ANGII) between Diabetic and Normal Man (1991) (0)
Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes (2011) (0)
REGIONAL CEREBRAL BLOOD-FLOW IN INSULIN-TREATED DIABETIC-PATIENTS EXPOSED TO RECURRENT SEVERE HYPOGLYCEMIA (1992) (0)
Self monitoring of glucose by people with diabetes. Self monitoring is vital for people with impaired awareness of hypoglycaemia. (1997) (0)
Hypoglycemia in hospital inpatients with diabetes – a problem revisited (2013) (0)
Cigarette Smoking, Limited Joint Mobility and Retinopathy in Type I (Insulin-Dependent) Diabetes (1988) (0)
The impact of hypoglycemia on quality of life in type 2 diabetes : a systematic review. (2010) (0)
The impact of diabetes on cognitive decline: potential vascular, metabolic, and psychosocial risk factors (2015) (0)
UNAWARENCE OF HYPOGLYCAEMIA (1990) (0)
Social Aspects of Diabetes (2010) (0)
Hypoglycemia in hospital inpatients with diabetes (2012) (0)
PS17 - 83. A systematic review and meta-analysis of the diagnostic accuracy of continuous glucose monitoring systems for hypoglycaemia detection (2012) (0)
Changes in Plasma Intact Parathyroid Hormone During Insulin-Induced Hypoglycaemia in Adrenalectomised Human Subjects (1992) (0)
Digital retinal imaging increases detection of diabetic retinopathy in a hospital‐based eye screening programme (1999) (0)
High Levels of Baseline HbA1c, FPG, and 2-Hour Postprandial Glucose Are Key Predictors for Not Achieving HbA1c < 7.0% at Six Months in People with T2DM Starting Insulin Glargine 100 U/mL (2018) (0)
Human insulin (1991) (0)
Out-of-Hospital Management of Diabetic Emergencies in Germany: Structural and Process Quality. (2021) (0)
TESTING PANCREATIC FUNCTION (1985) (0)
Suppression of endogenous insulin secretion after acute hypoglycaemia in man [proceedings]. (1979) (0)
Peripheral Erythrocyte Changes in Man in Response to Hypoglycaemia (1980) (0)
A new cause of neuroglycopenia: ‘missing the point’—impaired visual function during acute hypoglycaemia (2005) (0)
Community Capitals and Asset-Based Community Development: An Evaluation of the Beginning Again North Dakota Program (2008) (0)
Ultrasound detection of hepatic steatosis in Type 2 diabetes: the Edinburgh Type 2 Diabetes Study (2010) (0)
Diabetes and driving safety in India: The internet as a valuable source of information. (2022) (0)
Cognitive decline in longstanding type 1 diabetes: a role for severe hypoglycaemia. (2021) (0)
Abnormal Insulin Secretory Response to Food after Acute Hypoglycaemia in Man: Evidence for β-Cell Glucopenia (1980) (0)
Hypoglycaemia Case Study (2015) (0)
Licensing regulations for diabetes and driving--Two sides of the same coin? (2016) (0)
Management of people with diabetes as emergency medical admissions to hospital (2009) (0)
Effect of Preganglionic Sympathectomy on Metabolic Recovery from Hypoglycaemia (1979) (0)
Reply (2005) (0)
Irish Endocrine Society Proceedings of Annual Meeting (The Professor D. A. D. Montgomery Meeting), Regional Hospital, Galway, October 10th–11th, 1986 (1987) (0)
Priming and Inhibitory Effects of Glucose on Insulin Secretion from Perifused Rat Islets of Langerhans (1980) (0)
Response to Rosenn et al. (1998) (0)
Insulins and Regimens in Current Use (2013) (0)
Hypoglycaemia and cerebrovascular disease (2017) (0)
Hypoglycemia in police custody and in prison (2010) (0)
Hypoglycaemic coma associated with gastric carcinoma lain (2008) (0)
Personal View (1977) (0)
Increased CD40 ligand, C-reactive protein, and platelet-monocyte binding in patients with type 1 diabetes mellitus (2003) (0)
Edinburgh Research Explorer Cardiovascular risk factors and cognitive decline in older people with type 2 diabetes (2015) (0)
A Bayesian latent variable model for the consistency of symptoms reported during hypoglycaemia (2008) (0)
Iconography : Impaired awareness of hypoglycaemia: a review (2011) (0)
Effect of Hypoglycemia on Measures of Myocardial Blood Flow and Myocardial Injury in Adults With and Without Type 1 Diabetes: A Prospective, Randomized, Open-Label, Blinded Endpoint, Cross-Over Study (2020) (0)
[Immediate and long-term effects of hypoglycemia on the cognitive functions]. (1994) (0)
Optimal carbohydrate dose for treatment of non-severe hypoglycemia: a narrative review (2022) (0)
No difference in hypoglycaemic symptom threshold for insulin aspart and human insulin in type 1 diabetes patients (1999) (0)
Use of Insulin in Hospitals (2013) (0)
Putative roles of vasopressin and adrenaline in the mediation of acute changes in haemostatic function. (1987) (0)
Erratum: Hypoglycemia in the elderly: Watch for atypical symptoms. (2019) (0)

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What Schools Are Affiliated With Brian M. Frier?

Brian M. Frier is affiliated with the following schools:

University of Edinburgh