Brian Matthews
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Structural biologist at University of Oregon, studying determinants of protein stability by mutants in T4 lysozyme; editor of Protein Science journal
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Why Is Brian Matthews Influential?
(Suggest an Edit or Addition)According to Wikipedia, Brian W. Matthews is a biochemist and biophysicist educated at the University of Adelaide, contributor to x-ray crystallographic methodology at the University of Cambridge, and since 1970 at the University of Oregon as Professor of Physics and HHMI investigator in the Institute of Molecular Biology.
Brian Matthews 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Solvent content of protein crystals. (1968) (7581)
- Comparison of the predicted and observed secondary structure of T4 phage lysozyme. (1975) (4201)
- Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. (1992) (862)
- Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding. (1990) (695)
- An efficient general-purpose least-squares refinement program for macromolecular structures (1987) (678)
- A relationship between protein stability and protein function. (1995) (646)
- Structural basis of the action of thermolysin and related zinc peptidases (1988) (600)
- The helix-turn-helix DNA binding motif. (1989) (582)
- Three-dimensional structure of β-galactosidase from E. coli. (1994) (514)
- Three-dimensional Structure of Tosyl-α-chymotrypsin (1967) (489)
- Chlorophyll arrangement in a bacteriochlorophyll protein from Chlorobium limicola (1975) (469)
- Structure of the cro repressor from bacteriophage λ and its interaction with DNA (1981) (446)
- Structural and genetic analysis of protein stability. (1993) (427)
- Structural basis of amino acid alpha helix propensity. (1993) (419)
- Substantial increase of protein stability by multiple disulphide bonds (1989) (393)
- Structure of thermolysin refined at 1.6 A resolution. (1982) (389)
- Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism. (1968) (355)
- Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3 (1988) (320)
- Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution. (1987) (311)
- The structure of thermolysin: an electron density map at 2-3 A resolution. (1972) (287)
- Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. (2002) (285)
- Studies on protein stability with T4 lysozyme. (1995) (280)
- Structure and function of the methionine aminopeptidases. (2000) (274)
- Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. (1992) (271)
- Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme. (1993) (269)
- The conformation of thermolysin. (1974) (259)
- Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme (1988) (259)
- Metalloaminopeptidases: common functional themes in disparate structural surroundings. (2002) (258)
- Three-dimensional structure of thermolysin. (1972) (255)
- Structure of a bacteriochlorophyll a-protein from the green photosynthetic bacterium Prosthecochloris aestuarii. (1979) (250)
- Structure and X-ray amino acid sequence of a bacteriochlorophyll A protein from Prosthecochloris aestuarii refined at 1.9 A resolution. (1986) (247)
- LacZ β‐galactosidase: Structure and function of an enzyme of historical and molecular biological importance (2012) (245)
- Three-dimensional structure of human basic fibroblast growth factor. (1991) (242)
- The molecular basis of DNA–protein recognition inferred from the structure of cro repressor (1982) (242)
- Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis. (1991) (236)
- A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene (1993) (235)
- Intrahelical hydrogen bonding of serine, threonine and cysteine residues within alpha-helices and its relevance to membrane-bound proteins. (1984) (235)
- Stabilization of phage T4 lysozyme by engineered disulfide bonds. (1989) (234)
- Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme. (1991) (226)
- The response of T4 lysozyme to large‐to‐small substitutions within the core and its relation to the hydrophobic effect (1998) (224)
- Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. (1995) (222)
- A mutant T4 lysozyme displays five different crystal conformations (1990) (220)
- An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides. (1984) (220)
- Enhanced protein thermostability from designed mutations that interact with α-helix dipoles (1990) (216)
- Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein. (1987) (212)
- Genetic and structural analysis of the protein stability problem. (1987) (207)
- DNA-binding proteins. (1983) (207)
- Accurate calculation of the density of proteins. (2000) (199)
- Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme. (2000) (197)
- Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme. (1995) (197)
- A structural basis for processivity (2001) (197)
- A model binding site for testing scoring functions in molecular docking. (2002) (197)
- A structural view of the action of Escherichia coli (lacZ) beta-galactosidase. (2001) (196)
- Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis. (1982) (196)
- Toroidal Structure of λ-Exonuclease (1997) (195)
- A crystallographic study of the complex of phosphoramidon with thermolysin. A model for the presumed catalytic transition state and for the binding of extended substances. (1977) (194)
- Control of enzyme activity by an engineered disulfide bond. (1994) (193)
- Structural basis for the attachment of a paramyxoviral polymerase to its template. (2004) (189)
- Lessons from the lysozyme of phage T4 (2010) (187)
- Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing (1990) (182)
- The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB (2002) (180)
- Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues. (1989) (179)
- High resolution refinement of β‐galactosidase in a new crystal form reveals multiple metal‐binding sites and provides a structural basis for α‐complementation (2000) (179)
- A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme. (1993) (179)
- Testing a flexible-receptor docking algorithm in a model binding site. (2004) (177)
- Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. (1993) (177)
- Specificity of ligand binding in a buried nonpolar cavity of T4 lysozyme: linkage of dynamics and structural plasticity. (1995) (172)
- Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation. (2005) (172)
- Structural analysis of zinc substitutions in the active site of thermolysin (1995) (165)
- The three dimensional structure of the lysozyme from bacteriophage T4. (1974) (163)
- Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme. (1995) (160)
- Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. (1993) (158)
- No code for recognition (1988) (156)
- Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase. (2000) (152)
- Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme. (1991) (145)
- The refined structures of goose lysozyme and its complex with a bound trisaccharide show that the "goose-type" lysozymes lack a catalytic aspartate residue. (1995) (145)
- Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants. (1989) (145)
- Sequence and structure comparison suggest that methionine aminopeptidase, prolidase, aminopeptidase P, and creatinase share a common fold. (1994) (143)
- Structural and genetic analysis of the folding and function of T4 lysozyme (1996) (142)
- The structure of E. coli β-galactosidase (2005) (141)
- Goose lysozyme structure: an evolutionary link between hen and bacteriophage lysozymes? (1983) (140)
- A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme. (1996) (138)
- Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme. (2000) (137)
- Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by X-ray crystallography: a novel class of transition-state analogues for zinc peptidases. (1984) (134)
- Structural and thermodynamic analysis of compensating mutations within the core of chicken egg white lysozyme. (1993) (134)
- The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme. (1994) (132)
- Structural similarity in the DNA-binding domains of catabolite gene activator and cro repressor proteins. (1982) (129)
- Molecular basis of thermostability in the lysozyme from bacteriophage T4 (1979) (126)
- Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond. (1987) (126)
- Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation. (2000) (124)
- Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis. (1999) (123)
- Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis. (1992) (122)
- The γ Turn. Evidence for a New Folded Conformation in Proteins (1972) (122)
- Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. (1993) (121)
- Kinetic studies on Cro repressor-operator DNA interaction. (1987) (120)
- Crystal structure of the regulatory subunit H of the V-type ATPase of Saccharomyces cerevisiae (2001) (119)
- Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. (1990) (117)
- Type II restriction endonucleases: structural, functional and evolutionary relationships. (1999) (116)
- Covalent structure of a group-specific protease from rat small intestine. Appendix: crystallographic data for a group specific protease from rat intestine. (1978) (116)
- Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive. (1995) (115)
- A structure for thermolysin. (1972) (113)
- Binding of lanthanide ions to thermolysin. (1974) (113)
- Conservation of solvent‐binding sites in 10 crystal forms of T4 lysozyme (1994) (113)
- Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor. (1982) (111)
- Structure of the lysozyme from bacteriophage T4: an electron density map at 2.4 A resolution. (1978) (110)
- Reversible lattice repacking illustrates the temperature dependence of macromolecular interactions. (2001) (110)
- The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. (1998) (108)
- Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. (1990) (108)
- Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme. (2000) (107)
- Corepressor-induced organization and assembly of the biotin repressor: A model for allosteric activation of a transcriptional regulator (2001) (106)
- The extension of the isomorphous replacement method to include anomalous scattering measurements (1966) (104)
- Structure and symmetry of oligomeric enzymes. (1973) (104)
- Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site (2006) (103)
- The structure of rat mast cell protease II at 1.9-A resolution. (1984) (103)
- X-ray Crystallographic Studies of Proteins (1976) (101)
- Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. (1992) (100)
- Boron mimetics: 1,2-dihydro-1,2-azaborines bind inside a nonpolar cavity of T4 lysozyme. (2009) (100)
- Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin. (1989) (97)
- Determination of molecular weight from protein crystals. (1974) (97)
- Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala-->Ser and Val-->Thr substitutions in T4 lysozyme. (1993) (96)
- Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft. (1991) (96)
- EDPDB: a multifunctional tool for protein structure analysis (1995) (92)
- Comparison of the structures of carboxypeptidase A and thermolysin. (1977) (92)
- Structural studies of protein-nucleic acid interactions. (1983) (91)
- Crystallographic Studies of a Human Immunoglobulin (1968) (90)
- How amino-acid insertions are allowed in an α-helix of T4 lysozyme (1993) (90)
- Atomic CO-ordinates for tosyl-α-chymotrypsin (1969) (90)
- Comparison of protein structures. (1985) (89)
- Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites. (1994) (88)
- A systematic approach to the comparison of protein structures. (1980) (86)
- Structure and thermal stability of phage T4 lysozyme. (1987) (85)
- Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. (1991) (85)
- Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site. (1999) (85)
- Relation between hen egg white lysozyme and bacteriophage T4 lysozyme: evolutionary implications. (1981) (85)
- Structure of a hinge-bending bacteriophage T4 lysozyme mutant, Ile3-->Pro. (1993) (84)
- Structural basis of DNA-protein recognition. (1989) (83)
- Structural basis for the functional differences between type I and type II human methionine aminopeptidases. (2005) (82)
- Crystal structure of lambda-Cro bound to a consensus operator at 3.0 A resolution. (1998) (81)
- Stabilization of functional proteins by introduction of multiple disulfide bonds. (1991) (81)
- Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent. (1995) (80)
- Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues. (1999) (80)
- Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme. (1996) (80)
- Co-repressor induced order and biotin repressor dimerization: a case for divergent followed by convergent evolution. (2006) (79)
- Structure of Escherichia coli exonuclease I suggests how processivity is achieved (2000) (77)
- Toroidal structure of lambda-exonuclease. (1998) (76)
- Proposed α-helical super-secondary structure associated with protein-DNA recognition (1982) (75)
- Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59 (1993) (74)
- Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding. (2009) (74)
- Structure-based design of a lysozyme with altered catalytic activity (1995) (74)
- An oscillation data collection system for high‐resolution protein crystallography (1981) (73)
- Three-dimensional structure of beta-galactosidase from E. coli. (1994) (73)
- Structural, functional, and evolutionary relationships between lambda-exonuclease and the type II restriction endonucleases. (1998) (73)
- A mutant T4 lysozyme (Val 131 → Ala) designed to increase thermostability by the reduction of strain within an α‐helix (1990) (71)
- A review about nothing: Are apolar cavities in proteins really empty? (2009) (71)
- Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme (1996) (71)
- Structural studies of mutants of T4 lysozyme that alter hydrophobic stabilization. (1990) (69)
- Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme. (1991) (69)
- Local scaling: a method to reduce systematic errors in isomorphous replacement and anomalous scattering measurements (1975) (68)
- Comparison of the structures of cro and lambda repressor proteins from bacteriophage lambda. (1989) (68)
- Hydrophobic core repacking and aromatic–aromatic interaction in the thermostable mutant of T4 lysozyme ser 117 → phe (1993) (68)
- Common precursor of lysozymes of hen egg-white and bacteriophage T4 (1981) (67)
- Structure of a thermostable disulfide-bridge mutant of phage T4 lysozyme shows that an engineered cross-link in a flexible region does not increase the rigidity of the folded protein. (1990) (67)
- Structure of a bacteriochlorophyll-protein from the green photosynthetic bacterium Chlorobium limicola: crystallographic evidence for a trimer. (1974) (67)
- Structural features of the gamma subunit of the Escherichia coli F(1) ATPase revealed by a 4.4-A resolution map obtained by x-ray crystallography. (1999) (67)
- Structural and thermodynamic analysis of the packing of two alpha-helices in bacteriophage T4 lysozyme. (1991) (67)
- Structural comparisons of TIM barrel proteins suggest functional and evolutionary relationships between β‐galactosidase and other glycohydrolases (2008) (66)
- Protein-DNA interaction. No code for recognition. (1988) (65)
- Structural rigidity of a large cavity-containing protein revealed by high-pressure crystallography. (2007) (65)
- Structure of a green bacteriochlorophyll protein (1980) (64)
- Crystallographic determination of the mode of binding of oligosaccharides to T4 bacteriophage lysozyme: implications for the mechanism of catalysis. (1981) (64)
- Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin. (1989) (63)
- Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression (2006) (63)
- An X-ray diffraction study of inhibited derivatives of α-chymotrypsin (1966) (63)
- Comparison of the structures of Cro and λ repressor proteins from bacteriophage λ (1983) (62)
- Comparison of goose-type, chicken-type, and phage-type lysozymes illustrates the changes that occur in both amino acid sequence and three-dimensional structure during evolution (1985) (61)
- Cryo-cooling in macromolecular crystallography: advantages, disadvantages and optimization (2004) (60)
- The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution. (2000) (60)
- Determination of protein molecular weight, hydration, and packing from crystal density. (1985) (60)
- Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations. (2003) (58)
- Structure of a mercaptan-thermolysin complex illustrates mode of inhibition of zinc proteases by substrate-analogue mercaptans. (1982) (57)
- Core-packing constraints, hydrophobicity and protein design. (1994) (57)
- Repacking the Core of T4 lysozyme by automated design. (2003) (57)
- Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome. (2005) (56)
- 4 – X-Ray Structure of Proteins (1977) (56)
- A general method to assess similarity of protein structures, with applications to T4 bacteriophage lysozyme. (1978) (56)
- The introduction of strain and its effects on the structure and stability of T4 lysozyme. (1999) (56)
- Structural and thermodynamic characterization of T4 lysozyme mutants and the contribution of internal cavities to pressure denaturation. (2008) (55)
- Analysis of the effectiveness of proline substitutions and glycine replacements in increasing the stability of phage T4 lysozyme (1992) (54)
- Multiple alanine replacements within α‐helix 126–134 of T4 lysozyme have independent, additive effects on both structure and stability (1991) (54)
- Comparison of the crystal structure of bacteriophage T4 lysozyme at low, medium, and high ionic strengths (1991) (54)
- Structure of the nucleocapsid-binding domain from the mumps virus polymerase; an example of protein folding induced by crystallization. (2008) (53)
- Refinement of the structure of human basic fibroblast growth factor at 1.6 Å resolution and analysis of presumed heparin binding sites by selenate substitution (1993) (53)
- Competing protein:protein interactions are proposed to control the biological switch of the E coli biotin repressor (2001) (52)
- The binding of L-valyl-L-tryptophan to crystalline thermolysin illustrates the mode of interaction of a product of peptide hydrolysis. (1989) (51)
- Docking molecules by families to increase the diversity of hits in database screens: Computational strategy and experimental evaluation (2001) (51)
- The Conformation of the ε- and γ-Subunits within theEscherichia coli F1 ATPase* (2001) (51)
- Rare earths as isomorphous calcium replacements for protein crystallography. (1972) (50)
- Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles. (1988) (50)
- Structural basis for the unusual specificity of Escherichia coli aminopeptidase N. (2008) (50)
- A new DNA-binding motif in the Skn-1 binding domain–DNA complex (1998) (50)
- Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability. (1999) (49)
- Structural studies of mutants of the lysozyme of bacteriophage T4. The temperature-sensitive mutant protein Thr157----Ile. (1987) (49)
- Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme (2001) (49)
- Contributions of left-handed helical residues to the structure and stability of bacteriophage T4 lysozyme. (1990) (48)
- Structure of the cro repressor from bacteriophage lambda and its interaction with DNA. (1981) (48)
- Flexible‐geometry conformational energy maps for the amino acid residue preceding a proline (1992) (48)
- Hydrophobic Interactions in Proteins (2001) (47)
- Mutational analysis of protein stability (1991) (47)
- Structure of the constitutively active double mutant CheYD13K Y106W alone and in complex with a FliM peptide. (2004) (47)
- Racemic crystallography—Easy crystals and easy structures: What's not to like? (2009) (46)
- Use of NMR to Detect Water Within Nonpolar Protein Cavities (1995) (45)
- Accommodation of amino acid insertions in an alpha-helix of T4 lysozyme. Structural and thermodynamic analysis. (1994) (44)
- High-resolution structure of an engineered Cro monomer shows changes in conformation relative to the native dimer. (1996) (44)
- Amino acid substitutions far from the active site of bacteriophage T4 lysozyme reduce catalytic activity and suggest that the C-terminal lobe of the enzyme participates in substrate binding. (1982) (44)
- The role of calcium ions in the stability and instability of a thermolysin‐like protease (2011) (44)
- Refined structure of Cro repressor protein from bacteriophage lambda suggests both flexibility and plasticity. (1998) (43)
- Structure of a stabilizing disulfide bridge mutant that closes the active‐site cleft of T4 lysozyme (1992) (43)
- Determination of solvent content in cavities in IL-1β using experimentally phased electron density (2006) (42)
- Metalloaminopeptidases: Common Functional Themes in Disparate Structural Surroundings (2003) (42)
- Structural and genetic analysis of protein folding and stability: Current Opinion in Sturctural Biology 1993, 3:589–593 (1993) (41)
- Is gamma-chymotrypsin a tetrapeptide acyl-enzyme adduct of alpha-chymotrypsin? (1989) (41)
- Symmetry, molecular weight and crystallographic data for sweet potato -amylase. (1971) (41)
- How Cro and lambda-repressor distinguish between operators: the structural basis underlying a genetic switch. (1998) (40)
- Structure of the DNA binding region of prospero reveals a novel homeo-prospero domain. (2002) (39)
- Structural analysis of silanediols as transition-state-analogue inhibitors of the benchmark metalloprotease thermolysin. (2005) (39)
- Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions. (1998) (39)
- Structural analysis of the group II intron splicing factor CRS2 yields insights into its protein and RNA interaction surfaces. (2005) (38)
- Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59. (1992) (38)
- Structural analysis of the inhibition of thermolysin by an active-site-directed irreversible inhibitor. (1983) (38)
- Crystallization of beta-galactosidase does not reduce the range of activity of individual molecules. (2003) (36)
- Use of experimental crystallographic phases to examine the hydration of polar and nonpolar cavities in T4 lysozyme (2008) (36)
- High-resolution structure of the temperature-sensitive mutant of phage lysozyme, Arg 96----His. (1989) (36)
- Atomic coordinates for the chlorophyll core of a bacteriochlorophyll a-protein from green photosynthetic bacterial. (1977) (36)
- Kinetic and spectroscopic characterization of the H178A methionyl aminopeptidase from Escherichia coli. (2003) (35)
- Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. (1991) (35)
- Thermolysin in the absence of substrate has an open conformation. (2002) (35)
- Direct and indirect roles of His‐418 in metal binding and in the activity of β‐galactosidase (E. coli) (2009) (34)
- Parameter refinement in the multiple isomorphous‐replacement method (1973) (34)
- Can small cyclic peptides have the activity and specificity of proteolytic enzymes? (1994) (33)
- Binding of the biproduct analog L-benzylsuccinic acid to thermolysin determined by X-ray crystallography. (1979) (33)
- Crystal structure of an engineered cro monomer bound nonspecifically to DNA: Possible implications for nonspecific binding by the wild‐type protein (1998) (33)
- The structure of E. coli beta-galactosidase. (2005) (32)
- Rapid crystallization of T4 lysozyme by intermolecular disulfide cross-linking. (1994) (32)
- Structural basis for the altered activity of Gly794 variants of Escherichia coli beta-galactosidase. (2003) (32)
- Three-dimensional structure of tosyl-alpha-chymotrypsin. (1967) (31)
- Structure of gamma-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that gamma-chymotrypsin is a covalent acyl-enzyme adduct at low pH. (1991) (31)
- Structure-Based Design of an Inhibitor of the Zinc Peptidase Thermolysin (1994) (31)
- Crystal structure of E. coli YhbY: a representative of a novel class of RNA binding proteins. (2002) (31)
- Structure of a serine protease from rat mast cells determined from twinned crystals by isomorphous and molecular replacement (1985) (31)
- Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases. (2006) (31)
- A computer controlled film scanner for X-ray crystallography (1972) (30)
- Development of an in vivo method to identify mutants of phage T4 lysozyme of enhanced thermostability (1993) (30)
- Structural basis of Prospero-DNA interaction: implications for transcription regulation in developing cells. (2005) (30)
- Use of site-directed mutagenesis to obtain isomorphous heavy-atom derivatives for protein crystallography: cysteine-containing mutants of phage T4 lysozyme. (1987) (30)
- Inhibition of thermolysin and neutral endopeptidase 24.11 by a novel glutaramide derivative: X-ray structure determination of the thermolysin-inhibitor complex. (1994) (29)
- The role of solvent transport in cryo-annealing of macromolecular crystals. (2004) (29)
- Cro repressor protein and its interaction with DNA. (1983) (29)
- Relation between γ- and α-chymotrypsin (1968) (29)
- Five retracted structure reports: Inverted or incorrect? (2007) (29)
- Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding. (1999) (28)
- The photochemistry of 3,5-disubstituted 1,4-dihydropyridines. (1970) (28)
- High resolution structural studies of Cro repressor protein and implications for DNA recognition. (1983) (27)
- Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase (2006) (27)
- Crystallization of a complex of cro repressor with a 17 base-pair operator. (1986) (27)
- Some crystal forms of bovine chymotrypsinogen B and chymotrypsinogen A. (1968) (26)
- Proteins under pressure (2012) (26)
- Structural characterization of an engineered tandem repeat contrasts the importance of context and sequence in protein folding. (1999) (26)
- Use of differentially substituted selenomethionine proteins in X-ray structure determination. (1999) (25)
- Escherichia coli repressor of biotin biosynthesis. (1997) (25)
- Crystal structure of the BstDEAD N-terminal domain: a novel DEAD protein from Bacillus stearothermophilus. (2004) (25)
- Refinement of the Structure of a Water-Soluble Antenna Complex from Green Photosynthetic Bacteria by Incorporation of the Chemically Determined Amino Acid Sequence (1993) (25)
- Extension to 2268 atoms of direct methods in the ab initio determination of the unknown structure of bacteriophage P22 lysozyme. (2006) (25)
- Dissection of protein structure and folding by directed mutagenesis. (1992) (25)
- Dynamics of xenon binding inside the hydrophobic cavity of pseudo-wild-type bacteriophage T4 lysozyme explored through xenon-based NMR spectroscopy. (2005) (24)
- How amino-acid insertions are allowed in an alpha-helix of T4 lysozyme. (1993) (24)
- Different interactions used by Cro repressor in specific and nonspecific DNA binding. (1988) (24)
- Many gene-regulatory proteins appear to have a similar α-helical fold that binds DNA and evolved from a common precursor (1983) (23)
- A Structure for Thermolysin (1972) (23)
- Structural analysis of the temperature-sensitive mutant of bacteriophage T4 lysozyme, glycine 156----aspartic acid. (1988) (23)
- Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme. (2009) (22)
- Substitution with selenomethionine can enhance the stability of methionine-rich proteins. (1999) (22)
- Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme (2009) (21)
- Redetermination and refinement of the complex of benzylsuccinic acid with thermolysin and its relation to the complex with carboxypeptidase A. (1994) (21)
- Use of sequence duplication to engineer a ligand-triggered, long-distance molecular switch in T4 lysozyme. (2004) (21)
- Crystal structures of a T4-lysozyme duplication-extension mutant demonstrate that the highly conserved beta-sheet region has low intrinsic folding propensity. (2002) (21)
- Long-distance conformational changes in a protein engineered by modulated sequence duplication (2003) (20)
- Crystallographic data for complexes of the Cro repressor with DNA. (1983) (20)
- Structures of randomly generated mutants of T4 lysozyme show that protein stability can be enhanced by relaxation of strain and by improved hydrogen bonding via bound solvent (1993) (19)
- The structure and stability of thermolysin. (1976) (19)
- Perturbation of Trp 138 in T4 lysozyme by mutations at Gln 105 used to correlate changes in structure, stability, solvation, and spectroscopic properties (1993) (19)
- Protein Structure Initiative: getting into gear (2007) (19)
- Letter: crystallographic data fro lysoxyme from bacteriophage T4. (1973) (19)
- Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis. (1977) (18)
- Enhancement of the method of molecular replacement by incorporation of known structural information. (1994) (18)
- Crystal and molecular structure of [2.2](2,6)pyridinoparacyclophane-1,9-diene (1974) (18)
- Alanine‐scanning mutagenesis of the β‐sheet region of phage T4 lysozyme suggests that tertiary context has a dominant effect on β‐sheet formation (2004) (18)
- Use of a non-rigid region in T4 lysozyme to design an adaptable metal-binding site. (2000) (18)
- How does cro repressor recognize its DNA target sites (1983) (17)
- Crystallization of β-galactosidase from Escherichia coli (1992) (17)
- Crystallization of the bifunctional biotin operon repressor. (1989) (17)
- A method of obtaining a stereochemically acceptable protein model which fits a set of atomic coordinates (1976) (16)
- Relocation or duplication of the helix A sequence of T4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding. (2004) (16)
- Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability. (2003) (15)
- Changes at Protein Science (2008) (14)
- Atomic coordinates for T4 phage lysozyme. (1977) (14)
- Crystallization of designed protein variants (1990) (14)
- Structural basis for the action of thermolysin. (1992) (14)
- STRAT: a program to optimize X-ray data collection on an area detector system (1993) (14)
- Crystals of luciferase from Vibrio harveyi. A preliminary characterization. (1985) (13)
- The structure of a repressor: crystallographic data for the Cro regulatory protein of bacteriophage lambda. (1979) (13)
- Changes to crystals of Escherichia coli beta-galactosidase during room-temperature/low-temperature cycling and their relation to cryo-annealing. (2007) (13)
- Structural features of the g subunit of the Escherichia coli F 1 ATPase revealed by a 4.4-Å resolution map obtained by x-ray crystallography (1999) (13)
- The crystal and molecular structure of the "metallic reflector" 1,5-bis(dimethylamino)pentamethinium perchlorate (1976) (13)
- Evaluation at atomic resolution of the role of strain in destabilizing the temperature‐sensitive T4 lysozyme mutant Arg 96 → His (2009) (12)
- Generation of noble-gas binding sites for crystallographic phasing using site-directed mutagenesis. (2002) (11)
- An evaluation of electron micrographs of bacteriochlorophyll a-protein crystals in terms of the structure determined by x-ray crystallography. (1977) (11)
- Sequential reorganization of β‐sheet topology by insertion of a single strand (2006) (11)
- A test of proposed rules for helix capping: Implications for protein design (2002) (11)
- The Significant Properties of Vector Images (2007) (10)
- Crystallographic data for lysozyme from the egg white of the Embden goose. (1979) (10)
- The relation between gamma-and alpha-chymotrypsin. II. Direct comparison of the electron densities at 5-5 Angstrom resolution. (1970) (9)
- Structural and genetic analysis of electrostatic and other interactions in bacteriophage T4 lysozyme. (1991) (9)
- Crystallization of methionine aminopeptidase from Escherichia coli. (1988) (9)
- Sorting the chaff from the wheat at the PDB (2008) (9)
- The crystal and molecular structure of the polymethine dye 1,3-bis(dimethylamino)trimethinium perchlorate: a comparison of optical and X-ray crystal structure determination (1973) (9)
- From the new Editor (2007) (9)
- The structural basis for enhanced stability and reduced DNA binding seen in engineered second-generation Cro monomers and dimers. (2000) (9)
- Crystallization of mutant lysozymes from bacteriophage T4 (1988) (8)
- STRUCTURE OF BACTERIOPHAGE T4 LYSOZYME REFINED AT 1.7 ANGSTROMS RESOLUTION (1986) (8)
- Use of an ion-binding site to bypass the 1000-atom limit to structure determination by direct methods. (2004) (8)
- Beta-sheet models for the ordered filamentous structure formed by a peptide that enhances the action of insulin. (1996) (7)
- Stoichiometry versus hydrophobicity in protein folding. (2011) (7)
- L-RHAMNOSE ISOMERASE (2000) (7)
- Crystallographic data for chicken liver fructose bisphosphatase. (1977) (6)
- Can proteins be turned inside-out? (1995) (6)
- A helix initiation signal in T4 lysozyme identified by polyalanine mutagenesis. (1995) (5)
- Structural and Genetic Analysis of Protein Folding (1993) (5)
- Amino acid residues essential for biological activity of a peptide derived from a major histocompatibility complex class I antigen. (1993) (5)
- The Conformation of the Epsilon and Gamma Subunits within the E. coli F1 ATPase (2001) (5)
- [1] Recent transformations in structural biology. (1997) (5)
- THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF (1998) (5)
- Guanidinium derivatives bind preferentially and trigger long‐distance conformational changes in an engineered T4 lysozyme (2006) (5)
- Cloning, expression and crystallization of VMA13p, an essential subunit of the vacuolar H+-ATPase of Saccharomyces cerevisiae. (2000) (4)
- Crystallization of beta-galactosidase from Escherichia coli. (1992) (4)
- Structural and Thermodynamic Characterization of T4 Lysozyme Mutants and the Contribution of Internal Cavities to Pressure Denaturation (2009) (4)
- SOME USES OF THE RAMACHANDRAN (PHI ,PSI ) DIAGRAM IN THE STRUCTURAL ANALYSIS OF LISOZYMES (1990) (4)
- Isolation and characterization of multiple-methionine mutants of T4 lysozyme with simplified cores (1997) (4)
- Peripatetic proteins (2010) (4)
- How planar are planar peptide bonds? (2016) (4)
- Which of the 100,000 structures in the protein data bank are reliable? (2015) (4)
- Converting T4 Phage Lysozyme into a Transglycosidase (1998) (4)
- Crystallographic data for sturgeon holo-D-glyceraldehyde-3-phosphate dehydrogenase: a holo-D-glyceraldehyde-3-phosphate dehydrogenase with crystallographic 2-fold symmetry. (1977) (4)
- Binding of small electron-dense ligands in large protein cavities (1996) (3)
- Structural basis of protein stability and DNA-protein interaction. (1985) (3)
- An x-ray diffraction study of inhibited derivatives of alpha-chymotrypsin. (1966) (3)
- Protein Motifs: the Helix‐Turn‐Helix Motif (2007) (3)
- STRUCTURE OF THERMOLYSIN REFINED AT 1.6 ANGSTROMS RESOLUTION (1982) (3)
- Sequential reorganization of beta-sheet topology by insertion of a single strand. (2006) (3)
- Identification of SH3 motif in M. Tuberculosis methionine aminopeptidase suggests a mode of interaction with the ribosome (2005) (3)
- Structure and symmetry of oligomeric enzymes. (1973) (3)
- 18 – Approaches toward the Design of Proteins of Enhanced Thermostability (1990) (3)
- Structural and mutational analysis of protein stability (1996) (3)
- The Three Dimensional Structure of the Lysozyme from Bacteriophage T4 (protein (3)
- THE E. COLI BIOTIN HOLOENZYME SYNTHETASE(SLASH)BIO REPRESSOR CRYSTAL STRUCTURE DELINEATES THE BIOTIN AND DNA-BINDING DOMAINS (1993) (3)
- DNA-protein recognition (1984) (3)
- The Structural and Functional Roles of Metal Ions in Thermolysin (1978) (2)
- Structure of a bacteriochlorophyll a-protein from Prosthecochloris aestuarii. (1976) (2)
- The crystal and molecular structure of N-(4-bromobenzyl)isoquinolinium 4-dithiocarboxylate. An adduct of N-(4-bromobenzyl)isoquinolinium bromide and carbon disulphide (1973) (2)
- Interactive graphics return to protein science (2009) (2)
- THERMODYNAMIC AND STRUCTURAL COMPENSATION IN ""SIZE-SWITCH"" CORE-REPACKING VARIANTS OF T4 LYSOZYME (1996) (2)
- Selling candles in a post-Edison world: phasing with noble gases bound within engineered sites. (2003) (2)
- The Bragg legacy: early days in macromolecular crystallography. (2013) (2)
- Corrigendum to “Structural Analysis of the Group II Intron Splicing Factor CRS2 Yields Insights into its Protein and RNA Interaction Surfaces” [J. Mol. Biol. (2005) 345, 51–68] (2005) (2)
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- Obituary: Paul Sigler (1934–2000) (2000) (1)
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- Tools 2021: New methods, new approaches, and a salute to recent developments in protein science (2020) (1)
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- Crystal structure of phage T4 lysozyme mutant G28A/I29A/G30A/C54T/C97A (2004) (0)
- Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-Dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide (2006) (0)
- T4 LYOSZYME CORE REPACKING MUTANT I100V/TA (2003) (0)
- Are Carboxy Terminii of Helices Coded by the Local Sequence or by Tertiary Structure Contacts (2002) (0)
- T4 LYSOZYME MUTANT C54T/C97A/L121A/L133A IN THE PRESENCE OF 8 ATM ARGON (2000) (0)
- T4 Lysozyme mutant L99A at 200 MPa (2005) (0)
- New azaborine compounds bind to the T4 lysozyme L99A cavity - 1-ethyl-2-hydro-1,2-azaborine (2009) (0)
- Issue information (2021) (0)
- T4 lysozyme M102E/L99A mutant with buried charge in apolar cavity--Apo structure (2009) (0)
- Protein Science best paper awards to Yu‐ming Huang and Abhay Thakur (2019) (0)
- Control of the Catalytic Mechanism of an Enzyme by Amino Acid Substitution (1996) (0)
- T4 LYSOZYME MUTANT C54T/C97A/L99A IN THE PRESENCE OF 16 ATM KRYPTON (2000) (0)
- T4 LYSOZYME MUTANT M120K (1998) (0)
- CRYSTAL STRUCTURE OF T4 LYSOZYME MUTANT T152V (2001) (0)
- T4 Lysozyme Mutant L99A/M102Q Bound by Phenol (2002) (0)
- E. COLI METHIONINE AMINOPEPTIDASE: TRIFLUOROMETHIONINE COMPLEX (1999) (0)
- T26H Mutant of T4 Lysozyme (1999) (0)
- E. COLI METHIONINE AMINOPEPTIDASE: METHIONINE PHOSPHINATE COMPLEX (1999) (0)
- Crystal Structure of the BstDEAD N-terminal Domain (2003) (0)
- Studies on the crystallization of the cro protein-pseudo OR3 complex (1986) (0)
- CRYSTAL STRUCTURE OF BOVINE PEPTIDE METHIONINE SULFOXIDE REDUCTASE (2000) (0)
- Crystal Structure Analysis of Thermolysin Complexed with the Inhibitor (R)-retro-thiorphan (2005) (0)
- T4 LYSOZYME CORE REPACKING MUTANT A111V/CORE10/TA (2003) (0)
- CRYSTAL STRUCTURE OF THE CO(II)-BOUND GLYOXALASE I OF ESCHERICHIA COLI (2000) (0)
- E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-F-GALACTOSYL-ENZYME INTERMEDIATE (ORTHORHOMBIC) (2001) (0)
- Crystallographic and Genetic Approaches Toward the Design of Proteins of Enhanced Thermostability (1990) (0)
- cis‐1‐Acetyl‐4‐[1‐(4‐bromophenyl)‐2‐phenyl]‐vinyl‐3‐pyrrolin‐2‐one (1974) (0)
- crystal structure of bacteriophage P22 lysozyme mutant L87M (2006) (0)
- Structure of the Chloroplast Group II Intron Splicing Factor CRS2 (2004) (0)
- Protein structure and function / Brian W. Matthews (1985) (0)
- T4 LYSOZYME MUTANT V103M (1999) (0)
- T4 LYSOZYME MUTANT V87M (1999) (0)
- Measles virus P protein (amino acids 457-407) (2005) (0)
- Structure of the Group II Intron Splicing Factor CRS2 (2004) (0)
- T26D MUTANT OF T4 LYSOZYME (1999) (0)
- Crystal structure of phage T4 lysozyme mutant L32A/L33A/T34A/C54T/C97A/E108V (2004) (0)
- Free of ligand binding in the hydrophobic cavity of T4 lysozyme L99A mutant (2008) (0)
- Thermolysin with tricyclic inhibitor (2004) (0)
- E. COLI (LACZ) BETA-GALACTOSIDASE (G794A) WITH IPTG BOUND (2004) (0)
- Context‐dependent protein stabilization by methionine‐to‐leucine substitution shown in T4 lysozyme (1998) (0)
- Crystal Structure of E. coli PepN (Aminopeptidase N)in complex with Bestatin (2006) (0)
- CRYSTAL STRUCTURE OF CRO-F58W MUTANT (1999) (0)
- Binding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysis (1982) (0)
- 2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR (1994) (0)
- Crystal structure of human methionine aminopeptidase type 1 in complex with 3-tert-Butoxycarbonylaminopyridine-2-carboxylic acid thiazole-2-ylamide (2006) (0)
- N-TERMINAL DOMAIN CORE METHIONINE MUTATION (1999) (0)
- Determination of two organic crystal structures by X-ray diffraction (1963) (0)
- Stabilizing Disulfide Bridge Mutant of T4 Lysozyme (2001) (0)
- Correlations between structure and thermodynamic stability of phage T4 lysozyme (1987) (0)
- Slow-and Fast-Binding Inhibitors of Thermolysin Display Different Modes of Binding : Crystallographic Analysis of Extended Phosphonamidate Transition-State Analoguest (2009) (0)
- E. COLI (lacZ) BETA-GALACTOSIDASE-TRAPPED 2-DEOXY-GALACTOSYL ENZYME INTERMEDIATE (2001) (0)
- E. coli (lacZ) beta-galactosidase (H418N) (2008) (0)
- Crystal structure of E. coli Aminopeptidase N in complex with arginine (2008) (0)
- Duplication-extension of Helix A of T4 lysozyme (2004) (0)
- PHOTODIMERE VON 3-METHYLCYCLOHEX-2-ENON (1970) (0)
- David Davies: Structural biologist and mentor (2017) (0)
- Model Interaction Between BCCP and ATP-bound Carboxylase Subunit of acetyl CoA Carboxylase (2001) (0)
- CRYSTAL STRUCTURE OF CD(II)-BOUND GLYOXALASE I OF ESCHERICHIA COLI (2000) (0)
- Structure of gamma-chymotrypsin at 5.5 A resolution. (1969) (0)
- Thermolysin complexed with a novel glutaramide derivative, n-(1-(2(r,s)-carboxy-4-phenylbutyl) cyclopentylcarbonyl)-(s)-tryptophan (1994) (0)
- Circular permutation of Helix A in T4 lysozyme (2004) (0)
- T4 LYSOZYME MUTANT M6L (1998) (0)
- T4 LYSOZYME METHIONINE CORE MUTANT (1999) (0)
- Nice guys needn't finish last (1997) (0)
- Stoichiometry versus Hydrophobicity in Protein Folding (2011) (0)
- CRYSTAL STRUCTURE OF THE NI(II)-BOUND GLYOXALASE I FROM ESCHERICHIA COLI (2000) (0)
- BACTERIOCHLOROPHYLL CONTAINING PROTEIN (1998) (0)
- Issue information (2018) (0)
- Final data policy framework for Photon and Neutron RIs (2021) (0)
- Response : Alpha Helix Propensity of Amino Acids (1993) (0)
- Burning Bright: Impressions of Tim Winton (1986) (0)
- Review by Brian Matthews (1985) (0)
- Letter from Brian W. Matthews to Joshua Lederberg (1994) (0)
- Protein Science “Best Paper” awards to Youngil Chang and Liam Longo (2013) (0)
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